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State of BME-NC Spring 2016

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State of BME-NC Spring 2016 Winter 2015 | Spring 2016 Volume 4 Issue 1 Message from the Chair Zhen Gu Named One of 35 The UNC/NC State Joint Department of Biomedical Innovators Under 35 by Engineering is now 18 months into its five year MIT Technology Review strategic plan, and I could not be more eager to share our accomplishments thus far with you. Our Joint BME Assistant Professor three Strategic Priorities—creating a transformative Dr. Zhen Gu was named in MIT inter-institutional model, enabling global impact, and Technology Review’s 2015 list of securing resources to enable strategy—have been a 35 Innovators Under 35. This list great success and I am proud to say that BME has of innovators features inspiring and met or exceeded the implementation and initiation creative people who are creating of each of these goals. important emerging technologies. The selection process involves In particular, the hiring of six new faculty members- nominations from the public, MIT Drs. Ashley Brown, Michael Daniele, Jason Franz, Technology Review editors, and Donald Freytes, Xiaogang Hu, and Shumin Wang- has bolstered our first two international partners who publish priorities. Each of these new faculty members have enhanced our collaborative Innovators Under 35 lists in their model and conduct promising research that will undoubtedly lead to positive regions. Editors trim the list down global impacts. We are also currently conducting searches for a further six to 80 people, who then submit faculty to join our department in the fields of Rehabilitation Engineering, descriptions of their work and letters Pharmacoenginneering, Regenerative Medicine, and Medical Devices. These of reference. Outside judges rate additions have and will continue to allow us to develop our world-class standing. the finalists on the originality and We have also created and filled three new administrative positions that will impact of their work, then editors support our third priority of securing resources to enable our department to choose the final group of 35. continue to grow in size and excellence. Kyle Gray has joined as our Director of Development; Cheri Simpson as Director of Departmental Initiatives; and Preston Linn as our Academic-Industry Coordinator. These three are responsible for the development of our Joint Department through external funding, strategic partnerships, and internal projects. The Joint Department timeline is advancing smoothly. We are about to hit a milestone for our undergraduate program: in May of this year, our first group of students will graduate with a joint bachelors’ degree. This has been a primary objective that affords students unprecedented access to two Dr. Gu was selected as a result of world-class institutions and the opportunities therein. Our ongoing initiative his promising work with his insulin to develop a robust and organized industry internship/co-op program is just delivery patch. The patch is small one example of experience that our students gain through participating in a and covered with more than 100 Joint Department. In another exciting turn of events, the US News and World microneedles. The needles have Report has begun listing our program as a Joint UNC/NC State venture, rather tiny sacs filled with insulin and an than two separate institutional programs. After working for more than 10 enzyme, while the sac is permeable years to make this long overdue change, I hope for it to be a paving stone for enough to allow glucose inside. The what is to come. In future issues I look forward to reporting the achievement enzyme converts the glucose to an of many exciting milestones for all three of our Strategic Priorities. The Joint acid that makes the sac open and Department’s current success is certainly the result of the hard work of many release the insulin when sugar is too talented people and I invite you to explore their recent achievements that are high. Testing thus far has focused highlighted in this issue. on mice, but soon Dr. Gu will begin Nancy Allbritton, Ph.D., M.D., Professor & Chair testing his patch on pigs, whose Joint Department of Biomedical Engineering, UNC & NC State skin is more similar to humans. Eventually he hopes to create a patch that can be replaced every The Joint Department of Biomedical Engineering two to three days and control blood has a new website! Check it out at: sugar without much pain or effort. The image above was also included www.bme.unc.edu or www.bme.ncsu.edu in Science Magazine’s list of top 10 images of 2015. ENGINEERING the Quality of Life The Joint Department of Page 2 Biomedical Engineering REGENERATION | eMICRODEVICES | PHARMACOENGINEERING | IMAGING | REHABILITATION Feasibility and Safety of Contrast-Enhanced Ultrasound ATP-Responsive Drug Delivery Systems. Sun W, Gu Z. Publications in the Distal Limb of Six Horses. Seiler GS, Campbell N, Expert Opin Drug Deliv. 2016 Jan 8. [Epub ahead of print] Single-cell functional analysis of parathyroid adenomas Nixon B, Tsuruta JK, Dayton PA, Jennings S, Redding WR, PMID: 26745457 reveals distinct classes of calcium sensing behaviour in Lustgarten M. Vet Radiol Ultrasound. 2016 Jan 14. doi: primary hyperparathyroidism. Koh J, Hogue JA, Wang Y, 10.1111/vru.12333. [Epub ahead of print] PMID: 26765518 Nanomedicine: Anticancer Platelet-Mimicking DiSalvo M, Allbritton NL, Shi Y, Olson JA Jr, Sosa JA. J Cell Nanovehicles (Adv. Mater. 44/2015). Hu Q, Sun W, Qian C, Mol Med. 2016 Feb;20(2):351-359. doi: 10.1111/jcmm.12732. Activity of somatosensory-responsive neurons in high Wang C, Bomba HN, Gu Z. Adv Mater. 2015 Nov;27(44):7014. Epub 2015 Dec 5. PMID: 26638194 subdivisions of SI cortex during locomotion. Favorov doi: 10.1002/adma.201570298. PMID: 26634324 OV, Nilaweera WU, Miasnikov AA, Beloozerova IN. J Array-Based Platform To Select, Release, and Capture Neurosci. 2015 May 20;35(20):7763-76. doi: 10.1523/ Prediction of standard-dose brain PET image by using Epstein-Barr Virus-Infected Cells Based on Intercellular JNEUROSCI.3545-14.2015.PMID: 2599546 MRI and low-dose brain [18F]FDG PET images. Kang J, Adhesion. Attayek PJ, Hunsucker SA, Wang Y, Sims CE, Gao Y, Shi F, Lalush DS, Lin W, Shen D. Med Phys. 2015 Impact of guidance documents on translational large Sep;42(9):5301-9. doi: 10.1118/1.4928400 Armistead PM, Allbritton NL. Anal Chem. 2015 Dec animal studies of cartilage repair. Pfeifer CG, Fisher 15;87(24):12281-9. doi: 10.1021/acs.analchem.5b03579. Transformable liquid-metal nanomedicine. Lu Y, Hu Q, Epub 2015 Nov 23. PMID: 26558605 MB, Carey JL, Mauck RL. Sci Transl Med. 2015 Oct 21;7(310):310re9. doi: 10.1126/scitranslmed.aac7019. PMID: Lin Y, Pacardo DB, Wang C, Sun W, Ligler FS, Dickey MD, 26491080 Gu Z. Nat Commun. 2015 Dec 2;6:10066. doi: 10.1038/ Separation of peptide fragments of a protein kinase C ncomms10066. PMID: 26625944 substrate fused to a β-hairpin by capillary electrophoresis Design, fabrication and characterization of a bi-frequency Zigoneanu IG, Sims CE, Allbritton NL. Anal Bioanal Chem. co-linear array. Wang Z, Li S, Czernuszewicz T, Gallippi Cancer: a global concern that demands new detection 2015 Dec;407(30):8999-9008. doi: 10.1007/s00216-015- C, Liu R, Geng X, Jiang X. IEEE Trans Ultrason Ferroelectr technologies. Soper SA, Rasooly A. Analyst. 2016 Jan 9065-8. Epub 2015 Oct 1. PMID: 26427499 Freq Control. 2015 Dec 4. [Epub ahead of print] PMID: 4;141(2):367-70. doi: 10.1039/c5an90101d. No abstract available. PMID: 26688866 Osteoprotegerin is an effective countermeasure for 26661069 spaceflight-induced bone loss in mice. Lloyd SA, Morony Experimental Validation of ARFI Surveillance of Microfluidics for the detection of minimal residual disease SE, Ferguson VL, Simske SJ, Stodieck LS, Warmington KS, Subcutaneous Hemorrhage (ASSH) Using Calibrated in acute myeloid leukemia patients using circulating Livingston EW, Lacey DL, Kostenuik PJ, Bateman TA. Bone. Infusions in a Tissue-Mimicking Model and Dogs. Geist leukemic cells selected from blood. Jackson JM, Taylor JB, 2015 Dec;81:562-72. doi: 10.1016/j.bone.2015.08.021. RE, DuBois CH, Nichols TC, Caughey MC, Merricks EP, Witek MA, Hunsucker SA, Waugh JP, Fedoriw Y, Shea TC, Epub 2015 Aug 28. PMID: 2631890 Raymer R, Gallippi CM. Ultrason Imaging. 2015 Nov 27. pii: Soper SA, Armistead PM. Analyst. 2016 Jan 4;141(2):640- 51. doi: 10.1039/c5an01836f. PMID: 2652341 Chondroitin Sulfate Glycosaminoglycan Hydrogels Create 0161734615617940. [Epub ahead of print] PMID: 26614530 Endogenous Niches for Neural Stem Cells. Karumbaiah Tumor Microenvironment-Mediated Construction and Passive microfluidic chamber for long-term imaging of L, Enam SF, Brown AC, Saxena T, Betancur MI, Barker Deconstruction of Extracellular Drug-Delivery Depots Hu axon guidance in response to soluble gradients. Taylor TH, Bellamkonda RV. Bioconjug Chem. 2015 Dec Q, Sun W, Lu Y, Bomba HN, Ye Y, Jiang T, Isaacson AJ, Gu AM, Menon S, Gupton SL. Lab on a chip. 2015; 15(13):2781- 16;26(12):2336-49. doi: 10.1021/acs.bioconjchem.5b00397. Z. Nano Lett. 2016 Jan 19. [Epub ahead of print} PMID: 9. NIHMSID: NIHMS696357 PubMed [journal] PMID: Epub 2015 Oct 20. PMID: 26440046 26785163 26000554 Cryopreservation of neonatal cardiomyocytes. Elastic drug delivery: could treatments be triggered Altered tactile processing in children with autism spectrum Vandergriff AC, Hensley MT, Cheng K. Methods Mol Biol. by patient movement? Zhang Y, Yu J, Zhu Y, Gu Z. disorder. Tavassoli T, Bellesheim K, Tommerdahl M, 2015;1299:153-60. doi: 10.1007/978-1-4939-2572-8_12. Nanomedicine (Lond). 2016 Jan 19. [Epub ahead of print] Holden JM, Kolevzon A, Buxbaum JD. Autism Res. 2015 PMID: 25836582 PMID: 26783932 Nov 16. doi: 10.1002/aur.1563. [Epub ahead of print] PMID: 26568449 Targeted Transthoracic Acoustic Activation of Systemically Photo-Cross-Linked Scaffold with Kartogenin- Administered Nanodroplets to Detect Myocardial Perfusion Encapsulated Nanoparticles for Cartilage Regeneration Stimulating somatosensory psychophysics: a double-blind, Abnormalities.
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