BNL90B (T-371) (Biologyand Medicine- TID-45N,40th Ed.)

~~() -’,:J~ MEDICALSURVEY OF THE PEOPLE OF RONGEIAP AND UTIRIK ISLANDS NINE AND TEN YEARS AFTER EXPOSURE TO FALLOUT RADIATION (MARCH 1963 AND MARCH 1964)

NINE-YEARSURVEY

Roam A. bHARD, M.D.,’LEO M. *YER, M.D.: WATARU W. SUTOW,M.D.,’ WIuIm C. MOLOWT,M.D.: BRADFORDCmoN, M.D.,’ AROQATIHIc!uN6,PRACTITIONEIt,* RICHAROHAMWSTROM,P!kD.,l ANDEm RIKLOM,PWITIONER’ with ttm technicalassistanceof Wnmm A. SCOY1/’DOU61AS[Lmus; lRwm6JoftEs: Eufm ~DSY: bwmfa CooL’ Kosmi MIZUTQffIj’Smo SmfIs@’ AIfOKmm KIYYIEM’

TEN-YEARSURVEY ROBERTA. COMARO,M., Go k MEYEXM.D., Ausmn 10W, M.D.: ALVINC. WATNE,M.D.,’ ROOERT& CARTER,M.D.: AROSATIHICKIN6,PMcmmoMR BYRONBENDER,PH.D.: ISMC LANWI,PRACTITIONER:NO JHON ANJAM,PRACTITIONER’ with tho tuhnical assistanceof WHI.JAML $CO~, ~U61AS ~RElfS, wflUM wAfYifE,” Kosm Mfmowf,Sma SffoffIULtiwf Kmm, ANDW. GAYS*

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1 2 2 5 5 6 7 7 9 9 10 10 10 12 13 13 13 13 13 1’4 14 17 17 18 18 18 20 20 20 23 24 28 28 28 32 32 32 32 33 33 33 33 37 37 37 39 39

ii ... . Other hGmmw"St& ...... ‘M Chromosome Sm~u .....*v ...... 40 Dia&tic Smey ...... 41 Serological Stia ...... ’41 Pwek.*I*e *bnations ...... 41 Folic &Ai &&minau "om ...... 41 41 -!?-% s+ ...... “...... y~of*e Utie ...... 42 suMM2;?= ...... >...... 45 HeaIth S~.....+...... :...... 45 ~Mortality...... 45 .Aqhg ...... 45 Fertility, Miscarriages, Stillbirths, and Gepetic Effects.-, ...... l.. ..:, +&...... , ...... 46 Growth and Dcve@ment Smdiu..:= ...... k...... J...... d.,.“-...... 46 Development of~@*..#l...e ...... Y...... 46 Malignancy ...... +. .--.....+...... &=...... 47 “BetaBUm'' ...... "K...... +7 [ntemallv Absorbed Imto~ ...... 47 Other Examination ...... 48 .~C~OWLEXME~ ...... 48 REFERENCES... 49

hPENDIX i. Rongelap Group and Control Mean Blood Coun@ at Various Times After Exposure ...... +PPENDIX2. Ailingnae Group and Control lMean Blood Counts at Various Times After Ex~swe ...... 52 APpENDIX3. Utirik Group Mean Blood Counts at Various Jlmes Mer Exposure ...... 53 AppENDtX4. Individual Hematological Findings, 1963 ...... 54 .%PENDIX j . Individual Hematological Findings, 19& ...... 65 .+PENDIX 6. Individual Basophii Determinations, 1963 and 1964 ...... 74 .%WENDtX7. Individual Adult Physical Ftidin~ ...... 78 .APPENDtX8. Individual Children Physical findm~ ...... [00 .* PENDIX9. Anthropometric Study of Adult Mmhall~ ...... 1Q6 .* PENDtX 10. Nausea and Vomiting Following Exposure to Fallout of Mamhallese, LMarch 1, 1954 ...... 133 .*PENDtX 11. Pediatric Anthropometric Data (’Height and Weight), 1957 Through 1964, on Rongelap Control (Unexposed) children ...... 134 hpENDH 12. Pediatric .%tthropometric Data (Height and Weight), 1956 Through 1964, on Children Born to Exposed Parents, ...... 138 .tiPENDtX i 3. Pediatric Anthropomernc Data (Height and Weight), 1954 Through 1964, on Rongelap Exposed Chil&en ...... 140 .hPENDtx 14. Supplementary Anthropometric Data, Rongelap Control Children ...... [4’~ APPEXDIX 15. Supplementary Anthropometric Data on Children Born to Exposed Parents .... 153 APPENDIX 16. Supplementary Anthropometnc Data, Rongelap Exposed Children ...... 157 APPENDIX 17. Serum Folic .4cid Levels, 1963 ...... 166 .* PENDtX 18. Bone L~arrow Differential CounK ...... 167

. Ill .! ‘=. .=-, >.’ .% . .. . -.. 4.. -. iEDICAl_$lkYEiOF THE PhE OF RONGQAP AND UTIRIKISLANDS NIHE’#ii) ‘~ YEARSAFTEREXPOSURETO w ‘~lATION :* ‘“’ (MARCH1963ANO MARCH1964- .., ... .

-lntroduct@ -*i .-’ The resulti of a rn~cal sut&y ‘bftlie peopl : Rongclap in the Marshall Islands, carried out% March 1963 and March 1964,9 and 10 years&a people on Majuro Atoll sevcraihs@@d miles to the accident, arc presented in this rep Tl&: the south, where they lived for the following 3% people had been accidentally exposed to falIout years and were examined at yearly itsterv+ by a . radiation following a detonation of a high yield special medical team. In July 1957, M*. careful thermonuclear device during experiments at evaluation of the radioactive contamination situ- Bikini in the Pacific Proving Grounds in March ation, Rongelap ~~ wti c~dercd safe for 1954. An unpredicted shift in winds caused a habitation. A new vi~::wai constructed, and the deposiaon of significant amounts of fallout on four Rongclap people were moved there by Navy ship. inhabited .Marshall Islands to the east of Bikini The annual medicai surveys have since been car- (see Figure 1) and also on 23 Japanese fishermen ried out on Rongelap Island. aboard their fishing vessel, the Lucky Dragon. Of A group of more than 100 RongeIap people, the inhabitants of the island of Rongeiap, 105 who were relatives of the exposed people but had nautical miles away from the detonation, 64 re- been away horn the island at the time of the acci- the hrgpt f*ut cx~re: = eatim8te4. dent, moved back with the Rongelap people to ‘a”W , UF17!3 I’a&f wHW!kh&-gamrjta E8$htiom their home island and have served as an ideal “ofAof * s@k#imt =* ~. comparison population for the studies. This num- bet’ ~ce increased to about 200. Following - the i#ial survey of the Utirik people on Kwa-, jalein in 1954, a repeat survey was carried out in March 1957. In addition, during the paat survey, .= dose of aboufS------..

Rongelap people on Ailingnt@-. ELA?..-.”-”.”.”.- --- -

on thisisland and no &in effkcts d~.’

American servicemen, they were later returned to

their duty stations. The Utirik people were also F@rc 1. i%i+ of Fallout Area MAN RO allowed to return to their home island, where (Nlarch 1, 1954), .Varshall Islands. Qbo

1 2

T&i$ 1

Summary of MaAallae Popul.ati~ w- 1~ “’ . _ Group : No. in group

-.” ~N POWLAnONS ...... 1954 April Ma.. 115(aduAtsattdchildren) .... 7oo-ai 7 ~r~ . . 1956 ~ 57 *V .- 100&lo82 1957 >“ ,&&& 100 . %. 4, giN-9oo 1958 170 19 . . 8D1-970 1964 : RongeI@ 170 (age >10 only)” 801-1058

EXPOSaDPOPWLATSONS Rongelap 175 r) 67 (includa 3 Mutcro;annual exams) 1-86 .Ailingnae 70 r) 19 (includes 1 inuwo; annual exams) 1-86 American servicemen 28 (examined 1954 onlv) 401-428 Utirik ( 14 r) 157 (examined every 3 to 4 yearn) 2101-2257

UNEXPOSEDCKSLDILEN( <10 YaAasM OF1964) Rongelap & Ailingnae 45 (expmeciparents) 87-136 Rongdap 75 (unexposed parents) 801-1058 ~T~fi 20 {exposed parents) W58_2278

as in the previous sumeys, a visit was made to During the lint 24 to 48 hr after expmure, about Kwajalein and Majuro Atolls for examination of a % of the Rongelap people experienced anorexia number of Rongelap people, now residing at these and nausea. A few vomited and had diarrhea. In atolls, and also groups of children who represent appendix 10 the individual histories of nausea part of the control group used for the growth and and vomiting are tabulated. Many also experi- development studies of the exposed children. enced itching and burning of the skin, and a few Table 1 lists the various populations that have complained of lachrymation and burning of the been examined since 1954. eyes. Following this, the people remained asvmp- The accumulation of data fkom these surveys is tomatic until about 2 weeks after the accident, becoming increasingly voluminous. Since condi- when cutaneous lesions and 10SSof hair developed, tions have not been favorable for performance of due largely to beta irradiation of the skin. It was extensive statistical analyses or use of electronic apparent when the people were first examined, a computing procedures to store and manipulate the few days after exposure, that the Ivmphocvtes data, the annual survey reports published by this were considerably depressed and that sitytificant Laboratory are made as complete as possible. This doses of radiation had probably been received. In report, therefore, includes a considerable amount addition to the whole-body dose of radiation and of raw data, much of it in appendices, so that the beta irradiation of the skin, radiochemicai an- others may have an opportunity to make further alyses of the urine showed that measurable calculations if desired. amounts of radioactive material had also been ab- sorbed internally. The effects of the radiation can Summaryof PastPindings best be summarized under three headings accord- ing to the mode of exposure: penetrating irradia- Reports have been published on the findings of tion, skin irradiation, and internal irradiation. surveys made at the following times after expo- sure: initial examination,’ 6 months, z 1 year,J 2 HNErRNING RADIATION years,’ 3 veam, s 4 years,e 5 and 6 years,’ 7 yeas-d and 8 years.’ The following is a brief summary of One of the earliest findings indicative of signifi- the findings previously reported. cant exposure in these people was lowering of 3 levels of leukocytes and platelets of the peripheral weeks, w~ :h was followed by slower recovery but blood. This was most marked in the 64 people on “withmea.. .evels never reaching higher than 90 to Ronc@ap who had received 175 rads, and was less 95~o that of the comparison population during the marked in the other groups receiving less expo- 8 years post exposure. sure. The hemopoietic depression was roughly Eythropoidzc depression has not been a con- proportional to the dose of radiation received. sistent finding as with the leukocytes and thrombo- Even in the 157 Utirik people who received ordy cytes. Slight depression of red blood counts, hema- an estimated 14 rads, it was possible to distinguish tocrits, and hemoglobin has been noted at times. slight platelet depression in the group as a whole. No gross abnormalities of bonemarrow smears were The smaller group on Ailingnae and Rongerik reported at 6 months post exposure. At 8 years, showed peripheral blood levels between those of examination of 9 bone marrow aspirations from the high and low exposure groups. The chrono- exposed people showed a reduced mveloid-ery - logical records of blood findings in the Rongeiap throid ratio wth abnormalities of the erythroid and Ailingnae groups are presented in Figure 20, and myeioid precursors in 5 cases. z7, and 32 and in .Appendices 1 and 2, and in the Depression of peripheral blood elements in the Utirik group in Appendix 3. Ailingnae and Rongerik groups was not so pro- Lymphopen:a of about half the level of the com- nounced as in the Rongelap group. However, a parison ,Marshallese population was evident when slight lag in complete recovery in the Ailingnae the Rongelap people were firstexamined on their peripheral blood count has also been noted. arrival at Kwajalein 3 days after exposure. In The persistent depression of peripheral blood children <5 veam of age the Ivmphcqms dropped elements in the exposed people makes it appear to 2570 of the levels in the comparison children, likely that there is slight residual bone marrow but showed a slight rise during the following damage. weeks. The depressed Ievel was maintained with A general anemtc tendency has been evident in only slight increase noted by one year. In the fol- both exposed and unexposed Marahallese. Price- lowing year, mean counts approached the levels Jones curves, on the average, showed a slight of the comp&son population and have generally microcytic tendency. Serum iron levels have gen- remained slightly below. erally been normal, and the cause of this anemic .Veutrophil levels fluctuated considerably during tendency has been undetermined. the first month; possibly this was reiated to the Retictdocyte counts have been about the same prevalence of beta burns of the skin during that in the exposed as in the unexposed people. period. Neutrophil depression became evident by Except for radiation-induced lesions of the skin, 5 and 6 weeks post exposure with levels reaching patchy epilation, and early gastrointestinal symp- about half that of the comparison population in toms, clinical examinatwns have revealed no disease the adults and slightly lower in the children <5 processes or symptoms which could be related years of age. This degree of neutropenia was insuff- directly to radiation effects. ,No prophylactic or icient to result in any apparent increased infectious specific therapy of radiation effects was ever con- processes, and indeed it waa noted that neutro- sidered necessary or given. Epidemics of chicken phiiic leukocytosis was possible in people showing pox and measles that occurred showed no greater casual infections at this time. Neutrophil levels re- incidence or severity in the exposed than in the covered more rapidly than lymphocyte levels and unexposed Marshallese people. reached near control levels by one year. Subse- During the first months post exposure about half quent annual surveys have revealed that recove~ of the exposed group exhibited loss of wez~ht of sev- does not appear to be complete, particularly in eral pounds. This may possibiv have been reiated vounger and older age groups. to their radiation exposure, although it is difficult Platelet counts showed less fluctuation than other to rule out effects possibly due to change of blood counts and fairly consistently showed in- environment. creasing depression, reaching levels of about 30’%0 At 3 yearn post exposure the zmmunc response to pri- that of the comparison population by the 4th mary and secondary tetanus antitoxin was tested week. .4 spurt of recovery to about 75T0 of com- and found not to be significantly different in the parison levels occurred during the following few exposed compared co the unexposed populations. Five pemtms in the exposed population died of A cardiowmular surtq of the adults ( 1959): disease: (1) a %-year-old man with hypertensive showed no outstanding differences between the heart diseaae which had been present at the time exposed and unexposed groups. The people ap- of exposure, who died 2 years after the accident; peared to have less hypertension on the whole (2) a 78-year-old man who died, 3 years after ex- than is noted in people in the continental United posure, of coronary heart disease complicating States diabetes; (3) a 35-year4d man who died of acute An arthrztis suruq ( 1959)’ showed no great dif- varicella, 4 years tier exposure, who had received ferences between the exposed and the unexposed only 69 rads, having ben on Ailingnae at the time people, and alnmt the same incidence as is seen in of the fallout; (4) a W-year-old woman who died American populations. of a cancer of the ovary at 5 years after exposure; Ophthalmological suroeys showed no remarkable and (5) a 78-year-old woman who died of traumatic difference between the exposed and unexposed vertebral fractures at 8 years aiier exposure. There groups except possibly a slightly greater number was no apparent relationship between any of these of cases of pterygia, pingueculae, and corneai scam deaths and radiation exposure. Four deaths have in the exposed group. It is not known whether this occurred in the comparison population. The five finding is of any significance in relation to their deatha that have occurred in the exposed people radiation exposure. Slit-lamp observations showed since exposure represent a mortali~ rate of 7.6 per no opacities of the lens characteristic of radiation 1000 population per annum, compared with 8.3 exposure. As a whole, visual and accommodation for the Marshall Islands as a whole. levels in the Marshakse appeared to be above the Growth and akvebpnwnt studies on the children average in the U.S. population. (height, weight, anthropometric measurements, Dental suro~s’ showed no significant differences radiographic studies for bone age) have revealed in caries rate between exposed and unexposti that slight retardation in growth and development groups. However, the incidence and severity of has occurred in the expoacd boys who were under periodontal disease was slightly greater in the ex- 12 years of age at the time of exposure, particu- posed group. It is not known whether or not this larly those 12 to 18 months of age at exposure. finding is related to radiation effects. The poor Only slight immaturity was noted in the exposed oral hygiene generally obaetwed in the Marshallese female children. It was alao noted that children born had its usual results, nameiy, high caries rate in of exposed parents were slightly retarded and that teenage children, severe periodontal lesions in they had slightly lower levels of neutrophikt, lym- adulta (heavy calculua and loss of alveolar bone), phocytes, and piatek~ compared with maIe chil- and edentulous mouths in the aged. Radiation ex- dren of unexposed parents. However, since the lat- posure did not appear to have affected developing ter children were on the average 4 months older, the dentition in the exposed children. datadidmfi amnchsaion thatthedfkence in La&t t~tcts of radiation. Various parameters usu- stature was awciamclwith the exposure of the pamnta ally associated with aging were measured or esti- It was diflicult to evaluate the effects on fertility. mated on a O to 4+ scale (skin looseness, elasticity, However, a review of the birth ra& of the exposed and senile changes; greying of the hair and bald- group over the paat 8 yew seems to indicate no ing; accommodation, visual acuity, and arcus noticeable efhct of their exposure on fertility. The senilis; hearing; cardiovascular changa including 35 births represent a rate of 53 per 1000 popula- blood pressure and degrees of peripheral and ret- tion per annum compared with 37.3 for the Mar- inal arteriosclerosis; neuromuscular function: and shall Islands (1957). The 25 births over a 5-year hand strength). Comparison of these measure- period for the comparison population represent a ments in exposed and unexposed individuals of rate of 21.8 per 1000 population. A somewhat the same age groups showed no apparent differ- greater incidence of miscarriages and stillbirths was ences. A biological age score was calculated for noted in the exposed women during the tit 4 individuals and groups by use of an average per- years tier exposure, but because of the paucity centage score. LLJieshortening effects of radiation have of vital statistia on the Marshallesc and the small not been apparent. As noted, the mortality rate number of people involved, the data are not read- was about the same in the exposed as in the un- ily amenable to statistical analysis. exposed people. 5

The one case of cancer that developed in the ex- and atrophy at the site of the former bums. During posed group occurred at 5 years after exposure, the past several years an increased number of pig- toosoon, it is believed, to bear any particular rela- mented maculae and moles have been noted in tion to radiation exposure. Leukemxa surveys in- previously irradiated areas of the skin, but these cluding physicar findings, studies of white cell have appeared to be quite benign. counts and types, alkaline phosphatase staining, Numerous histopathological studies have been and basophil counts of 4000 white cells showed no made,’”5 and the changes found have been con- evidence of leukemia or leukemic tendency. One sistent with radiation damage. At no time have child in the irradiated group has had slightly ele- changes been observed either grossly or micro- vated basophils but no other positive findings. The scopically indicative of malignant or premalignant cardiovascular and arthrztis surveys, as well as the change. Spotty epilation on the heads was short general results of the physical examinations, have lived, regrowth of hair occurring about 3 months not shown any apparent increased incidence of after exposure and complete regrowth of normal degenerate diseases in the exposed people. No hair bv 6 months. No further evidence of epllation radiation-induced cataracts have been observed in has been seen. any of the exposed people. An interesting obsetwation noted during the first Cenctz effects have not been specifically studied few months after exposure was the development of because of the small number of people involved. bluish-brown pigmentation of the semilunar areas No apparent radiation-induced genetic changes of the fingernails and toenails in about 90% of the have been detected on routine physical examina- people. By 6 months this pigmentation had disap- tion in the first-generation children of exposed peared, having grown out with the nail. The cause parents, with the possible exception of suggestive of this phenomenon has not been explained. evidence of increased miscarriages and stillbirths in the exposed women and the slight retardation INTERNAL IRRADIATION of growth noted in the male children of exposed Radiochemical analyses of numerous urine sam- parents. ples of the exposed population showed internal ab- sorption of radioactive materials, pro bablv BETAIRRADIATIONOF THE SKIN brought about large!y through eating and drink- It was impossible to get an accurate estimate of ing contaminated food and water and to a lesser the radiation dose to the skin. Beta burns of the extent through inhalation. During the first few skin and epilation appeared about 2 weeks after days when the body levels were at their highest, exposure, largely on parts of the body not covered the maximum permissible concentrations were ap- by clothing. About 90% of the people had these proached or slightly exceeded only in the case of bums, and a smaller number deveioped spotty strontium-89 and the isotopes of iodine. The con- epiiation of the scalp. Most of the lesions were centrations were believed to be too low to result in superficial; they exhibited pigmentation and dry, any serious effects. Body levels fell rapidly. so that scaly desquamation, and were associated with bv 2 and 3 yearn post exposure, they were far little pain. Rapid healing and repigmentation fol- &low the accepted maximum permissible level: lowed. Some lesions were deeper, showed wet d- by 6 months activity in the urine was barely quamation, and were more painful. A few burns detectable became secondarily infected and had to be treated In 1958 analyses of bone samples on one of the with antibiotics. Repigmentation of the lesions men who died showed 3.7 strontium-90 unitsl’g gradually took piace in most instances, and the calcium. Beginning in 1957, gamma spectroscopy skin appeared normal within a few weeks. How- by use of a low-level counting chamber was added ever, in about 15V0 of the people, deeper lesions, to the techniques of radiochemicai analysis. The particularly noted on the dorsum of the feet, con- return of the Rongelapese to their home idand tinued to show lack of repigmentation with vary- (which after careful survey was considered safe for ing degrees of scarring and atrophv of the skin. By habitation, despite a persisting low level of radio- 6 years the only residual effects of beta radiation active contamination) was reflected in a rise in of the skin were seen in 10 cases which showed their body burdens and increased urinary excre- varying degrees of pigment aberrations, scarring, tion of certain radionuciides. During the veatx 6 since the original contaminating event, additional burden of 11.4 mpC. These levels represent about weapons tests held in the area have contributed co a sixfold increase in Sr90 over the 1958 levels. the fission products in the environment. Since the Little of the body burden of the exposed group diet includes a variety of imported foods, the peo- is apparently due to their initial exposure, since at ple a~c not living in a “closed’’environment, and present there is little difference between the levels therefore may not be rapidly approaching equi- of the exposed and unexposed populations living librium with the environmental fission products, on Rongelap Island. The body burdens are of as might be expected under other circumstances. small significance in terms of radiation hazard. Body burdens of gamma-emitting fission prod- ucts (such as CsL3’ and Zn85) were measured in a OTHERSTUDIES whole-body counter and checked by radiochemi- cal analysis of urine specimens. The levels of in- Studies of gettettcal~ mhcrited charactwsttcs. %[ood ternal contamination per unit weight appeared to grouping studies in the Marshallese showed a rela- be about the same for juveniles as for aduhs, male tively high B gene frequency, a high N gene fre- and female. Wide variations in leveh of contami- quency, an extremely high R’ gene fkequencv, and nation in any group were found, apparently due total absence of Ken and Diego factors.’” These to differences in diet and metabolism. characteristic differ &om those of Polynesians and Body burdens of Sr’O were estimated from uri- suggest relationship with Southeast Asians and nary excretion as determined by radiochemical Indonesians. Haptoglobin ~tudies showed the fre- analyses. Both the external dose measurements on quency of the Hp’ gene to be higher than in Euro- Rongelap IsIand and the leveis of radioactive ~ pean populations thus far tested and consistent topes in the food on the island indicated that some with populations living near the equator.” The dis- increase in Cs 13T,zne~, ad Srrn body burdens w= tribution of haptoglobin types showed the popula- to be expected when the people returned there in tion to be relatively homogeneous. ~ram~errzm in 1957. The Cs’3’ body burden in 1958 was about all sera were type CC, the common European 0.68 PC, about 60 times as great as in 1957, and type. /3-Amino- iso-bu~ric and urinary levels showed the urinary Cs’” level rose by a factor of 140; the the Marshalkse to be the highest excreters of this mean body burden for 1959 was 0.57 PC. The acid of any population thus t% reported. Levels in mean body burden of Znb’ estimated km whole- the exposed group were about the same as in the body counting data was, in 1958, after the return unexposed group, and no correlation was found to Rongelap, 0.36 PC, 8 times as high as in 1957, with body burden level of radionuclides: this indi- and 0.44 PC in 1959. In 1961 the mean Csa3r body cates that there is probably no correlation with ra- burden in adult males was 14.7 mpC/’kg, which is diation exposure. Hemoglobm ppes were considered not significantly different from the mean value of normal (all had type AAt ), Sickling tests showed no a similar group obtained in 1959; it was 300 times sickling tendency in any of the people. CluCOSt-6- that of the medical team, who were measured at phosphut~ dehydrogenae of the red cells appeared to the same time for comparison. The Zn” level in be normal in the ,Marshailese. Studies of Cm adult males (1.5 1 mpC/kg) dropped to 17~o of the pheno~pes showed the ~Marshallese to have 100% mean value measured in 1959. With a larger de- Gin””’ and nearly 100% Gm’ b-’. There was a tector and a longer counting time than previously complete absence of GmX and a high frequency employed, it was possible to identifi and quanti~ of Cm-like (Gmc). Considerable caution must be Co*” for the first time in these people; the mean exercised in evaluating the results of these studies level of Co’” was about 11% of the Zn6’ level. A on genetically inherited characteristics because of small amount of residual activity was still present the small number of samples tested. The data do after the subtraction of K’” and the above radio- seem to indicate relative homogeneity of the pop- nuclidcs &om the total spectrum. The mean ievel ulation and closest kinship with people of South- of ut’in~ excretion of Srgo w= 7. ~ pC/1 or 14~o east Asia. These data also may be usefui as a base higher than measured in the 1959 medical sur- line should genetic changes appear in later gen- vey. In 1962 the mean urinary Srgo level was 114 erations, pmsibly related to radiation exposure. @/g Ca, giving an estimated body burden of 12.0 Results of other laboratory studies included the mpC. Analysis of bones from the deceased Ron- following: Serumprotein levels were generallv on the gelap woman ( 1962) gave an estimated body high side of normal; eiectrophoretic patterns 7 showed the increase in proteins was largely due Immunoefectrophoretzc ana~s~ showed neither a to an increase in the gamma globulin fraction. The paraproteinemia nor a typical picture of antibodv- reason for this is not apparent. ~umerous chronic deficiency-syndrome, but a high frequency of in- infections may be an explanation. creases of some of the immunoglobulins was noted. Sodium ieuds in- the urine and food indicated Blood vo[ume studies with Cr” -labeled sodium about the same consumption of NaCl as in Ameri- chromate showed a significant reduction in red cans. The generally lower incidence of hyperten- cell mass and/or plasma volume in 15 of 23 sion in the Marshallese might be related to the Marshalkse. fact that the former native diet was probably lower in salt content than the present, more west- WPUULTIES ASSOCIA~ ernized diet. It will be interesting to see whether WITH TNE EXAMINATIONS the incidence of hypertension will later increase. Strum choltsteroi levels ( 1957, 1959) were some- As mentioned in previous reports, several diffi- what lower in the exposed population than in the culties were associated with carrying out the ex- comparison or Utirik populations, but were in the aminations as well as interpreting the findings. low normal range. No abnormally low readings 1. The language barrier made examinations dif- were noted. ficult, since very little English is spoken by the Serum creatinme levels ( 1957) were in the normal .Marshalksc. However, there were sufficient Eng- range with no abnormal levels noted. lish-speaking Marshallese to assist the medical %um uitamin B,, concentrations ( 1958, 1959) team in moat instancea. were generally significantly higher than American 2. The lack of vital statistics or demographic levels. The pasibility of contamination of the sam- data on the Marshake imposed a serious diffi- ples with bacteria producing vitamin B,2 must be culty in interpretation and evaluation of the medi- considered, since myeloproliferative and liver dis- cal data. Records of births, deaths, etc., have been eases were not seen. made by the health aides or magistrates of the vil- Serrsmprotein bound iodine levels ( 1957, 1959, 1962) lages and supposedly forwarded to the district ad- were generady slightly elevated. Evidence for thy- ministrator; however, such records have been in- roid dysfunction was not apparent in the people. complete or lost in most instances, and vital statis- Glruosuria and deuated blood sugar were found in 8 tics are therefore inadequate. Trust Territory people (1 expaecl and 7 unexposed). An increased officials are now attempting to assemble such data. incidence of diabetes is prevalent in the Mar- 3. There is uncertainty on the part of some of shalkae peopk. the Marshalkse as to their exact ages, particularly A suswey for intestinal pamsit~s (1958) showed among the older group. This imposes certain diffi- 75’%. of the peop~e to be inf-ted with various culties in interpreting some of the studies to be ~~. 11 For the three major pathogens fo~d, the outlined. over-all infection rates were, for Errtamoeba hi$to- ~tica, 18.2%o; for hookworm, 5.5%; and for ?richuris COMPARISON POPULATIONS trichiura, 34.3??0. Eosinophilia > 5% haa consistently been noted During the first 2 years, two separate groups of in about half the people. The fact that half the Marshalkse people were used for comparison, cases with eoainophilia showed no helminthic in- each of comparable size to the exposed Rongelap fections at all suggests that other factors besides group and matched for age and sex. However, this parasitic infections must be responsible. The eo- population was found to be unstable, with a large sinophilia may be related to chronic fungus and attrition rate over the 2 years, which made it un- other infections, particularly of the skin. satisfactory. At the time of the 3-year survev, it Compiernentjixation studies for parainfluenza 1, 2, was found that during the preceding 12 months and 3, respiratory syncitial, psittacosis, and Q fe- the Rongelap population at Majuro Atoll had ver showed antibodies to all groups of viruses ex- doubled because of the influx of relatives who had cept that for &ian influenza, which probably had come back from other isiands to live with them. not yet seriously involved the people of the Mar- These people had been away &om Rongelap .Atoll shall Islands. The antibody titers appeared to be at the time of the accidental exposure. This group somewhat lower in the exposed people. matched reasonably well for age and sex and was 8

—

Figure 2. .Medical survey team for 1963 (up~r picture) and 1964 (lower picture). ,Manv membm of the team are Micronmiam of the Trust Terr- itorywho work with the AEC medical specidku in carq+ng out the survey. Figure 3. Trust Territory ship bringing team and medkai quipment at anchor off L7tirikIsland

Table 2

Location of Ronqclap Peopie, 1964

Exposed Unexposed

Adults Children Children of exposed parents A&la ChMrcn Total

,Majum 3 1 3 7 7 21 Kwajaiein 9 6 11 37 40 I03 Rongelap 34 20 29 12 49 ?04 Eniaetok o 0 0 3 1 i Other atolb 2 1 0 13 11 27 Total 4a 28 43 132 108 359 of comparable size. Since the return of the peop[e children of the comparison population). The ma- to Rongelap, however, this group has about jority of these people were examined on Rongelap doubled in Sk Atoll, but about 100 of them were examined at Ebeye (Kwajalein Atoll) and a few at Majuro Atoll. In addition, Utirik Atoll was visited and 84 Organization expmed people were examined there. The survev team consisted of 10 physicians and technicians from the United States and 6 from the Trust Ter- 1963 SURVEY (9 YEARS POST EXFOSURE) ritory of the Pacific Islands (see Figure 2). A Trust Examinations wet-c conducted on the following Territory ship, the M/V Roque, was used to trans- Rongelap people: 70 exposed, 35 chiidren of ex- port the medical team to the Islands ( Figure 3). posed parents, and 196 unexposed (adults and The team lived ashore rather than on board ship 10

at Rongelap Village and also at Utirik Village PrOeedures while carrying out the examinations on these islands. PNYSKAL EXAMINATIONS

— Since both the 1963 and 1964 surveys were 1964 SIJRVEY (10 YEARS POST EXPOSURS] similar in scope and procedures, they will be de- scribed together. Hisstorim were taken bv a Mar- The 1964 survey did not include Utirik~kincc shallese practitioner with particular emphasis on these islanders are examined only every 3 to 4 the interval history during the past year. During years in view of the small exposure they sustained the 1964 survey Mr. Byron Bender, anthropol- ffom the fallout. Examinations were carried out aa ogist flom the Trust Territory, accompanied the in 1963 at Rongelap, Ebeye, and Majuro, the ma- medical team and carried out exhaustive studies jority being done at Rongelap. Table 2 show the on the genealogical background of the Rongelap distribution of Rongelap people on the various people. These data are not published in this re- atolls. Examinations were conducted on 70 of the port, but are available to those interested. The exposed Rongelap people, the 43 children of ex- pediatrician on the 1963 survey LW.W.S. ) carried posed parents, and 208 of the adults and children out further interviews with the Rongelap peopie of the comparison population. The survey team in order to establish more closely the ages of some consisted of 8 physicians and technicians horn the of the children, which were questionable. United States and 8 from the Trust Territory (see Complete physical examinations on both chil- Figure 2). The Trust Territory ships M/V Roquu dren and adults were carried out in both years. and M/V Ran Anim both aided in transporting the In addition, anthropometric measurements were team and equipment to and horn Rongelap Atoll. done on adults >19 years of age in order to de- The team lived at Rongelap Village for the exami- termine certain ethnic characteristics of the Mar- nations on that island. shake. During the 1963 examination extensive anthropometric measurements were also carried out on the children as part of the growth and de- velopment studies, and radiographs of their wrists were taken for the same studies...... In 1963 an ophthalmologist carried out com- plete ophthalmological examinations including slit- lamp observations. Cancer detection, emphasized during examina- tions for both years, included an evaluation of the history, special physical examinations, and cer- tain laboratory teats. ● The family history did not yield satisfactory information, since the incidence of familial diseases including cancer was generallv unknown by the people. The history vieided some information on changes in weight, history of iilness. and, in the case of women, menstrual, obstetric, and nursing history. In the physicai examination particular emphasis was placed on examination of the skin, node-bearing areas, head and neck. chest, breast, abdomen, and external genitalia. Pelvic examinations were carried ouc on all mature females, and vaginal and cervical smears for

Papanicolaou examinations were obtained. * ● Rec-

“Drs.E. Schmkowand H.L. Atkinsof Brookha.en Xauonal La&ratory interpretedthe x-ravfilms. ..we ~fi to thank Dr. G.smevieveBaderof Mernmal SiOaII Figure 4. .Marshallesc man carrying a sack of copra. KetteringCancerCenter,New York,NY., for,nterpreratlonof Copra is the main product in the economy of the Islands. the Papanicolaousrnean. 11

-. ..-...... - . . ..- . .“. . -. . . .

Figure 5. Rongclap people awaiting examinations. Fhmre 7. Slit-lamn examination of eva for lens o~acitics.

..

v

1.

- ‘7 i-= ?.. , ., -., . F@re 8. Biopsy of the skin. Figure 9. Typical MamhallcIc living conditions at Utirik. the stage of chromosome preparations. Chromo- some studies of peripheral blood cultures, however, have been considerably more successful. During tal examinations were carried out on all penons 1963 a Iarge number of bioods were cuitured suc- >40 years of age. This included in the case of cessfully. However, the final chromosome spreads men palpation of the prostate gland. Radiographs in many cases were not completely satisfactory, of the chest and other parts of the body were ob- and the study was repeated during the 1964 sur- tained as indicated. Hematological data were vey. At this time successful 2- and 3-day biood obtained and were available for evaluation. cultures were obtained on 64 exposed people and In detection of possible leukemia (or preclinicai 11 unexposed. Excellent growth and chromosome evidence of incipient leukemia) the lymph nodes sprea& were obtained, and the slides are now and spleen were carefully examined; hematoiogicai being cvaiuatcd. * data were analyzed, including routine hemograms Sera were collected both years on most indi- and percent basophils in 4000 white cell count; viduals, and the foilowing examinations were and alkaline phosphatase smears of the white carried out in U.S. laboratories: protein-bound blood cells where done were availabie for review. iodines on 9 exposed and 8 unexposed peopie and a few blood sugar detertninaaons; ** serum foiic acid laboratory PROCEDURES levels on 52 cxpcscd and 85 unexposed people.””” During the 1963 survey 38 urine sam pies were Hematologicai studies included white cell counts with differentials, red blood counts, hematocrits, collected, and during the 1964 survey 27 samples, for radiochemical analyses.’ Most of these were hemoglobins, piatelet counts, serum proteins, blood smears for alkaline phoaphatase, and base 24-hour samples, though several pooied samples were obtained. Most were from peopie living on phil count studies. Techniques fix these proceduru have been described in previous reports. ” Bone Rongclap Island, but some were obtained at Ebeye. marrow aspirations for diffknerttiai study were col- “Assutmg in these studies are Dr. Shields Warren and Dr. lected on 4 exposed and 2 unexposed individuals. ermann ham at the ANewSngland DeaconeasHospital. .Mb Considerable effort waa spent on chromosome ‘&s Sttoudat &gonnc National140mtory, andMissPatricia Cmmrirmat the Women’$MadicafCoflege, Philadelphia. We studies in the past two surveys. Of particular in- ~ .P@fil to w. Michael Benderand Carolyn&rochof Oak terest was the possibility of studying the chromo- Ridge, W.M. Caurt-Brownof Edinburgh, Scotland. and Kurt somes of cells cultured !i-ctm the “beta bum” areas Hinhorn of New YorkUniversityforadvice. **Dr L.V. H-km and the Clinical Chemmy Group in the of the skin. Some 50 skin biopsies were obtained Mcdkal Departmentof BrookhavenNational Laboratorywere and successfully grown in most cases. However, rm~mlble forrhmcan+am. contamination of these cultures occurred under “**Dr.ThomasLynch,HackensackHostxcal,Hackensack.Y J., did the tidicaciddctcmunarions. the field conditions of these studies, and unfortu- tDr. EdwardHardyand or.hemat the AEC HealthandSatew nately all were lost before they could be brought to Laboratory,NW York,.N.Y.,carriedout theseanal=. 13

Findings “ preceded by d~rientation and amnesia with con- vulsive seizures and finally coma. .Autopsv showed INTERVALMEDICALHISTORY meningeal damage grossly and histologically. Illnouaa Brain damage was the likely cause of death. Other findings were few, but of interest was notation of The outstanding medical event during the past giant and multinucleated cells in the meninges 2 years on Rongelap was a poliomyelitis (tvpe I) area. * (4) No. 52, female, 55 years of age. Died, epidemic, which occurred eariy in 1963. The epi- February 1963, with laryngeal paralysis during demic apparently was carried from atoll to atoll the poliomyelitis epidemic. Death appeared to be by the crew of a ship, since it broke out on each &om poliomyelitis with bulbar involvement. NO atoll within a week or two after that ship had autopsy was obtained. departed. The epidemic occurred on Rongelap There was one death of a child of an exposed par- Atoll in January-February 1963 with 23 chiidren ent: No. 107, female, 4 years of age. Died in Oc- and 3 adults stricken and one of the adults (an tober 1962 of acute gaatroenteritis and dehydra- eider exposed woman) succumbing. The children tion. Child had a history of malnutrition and involved were all <7 years of age. Eleven were weakness, skin infections, loss of pigment in hair. children of exposed and 12 of unexposed parents. NO autopsy was done. Mild residual facial or limb paralysis was present During 1963 one death occurred in the exposed in 8 and more severe paralysis in 2 children. These group: the oldest Rongelap woman, estimated to cases will be firther described under the Pediatrics be around 107 yean of age; death was reported as Section. This epidemic was brought under control due to “old age.” Unfortunately, no autopsy was within a few months by widespread usc of oral obtained. She had been known to be quite feeble Sabine vaccine by medicaI persomel of the Public and had cataracts and a considerable degree of Health Setwice, Trust Territory, and Navy. Fortu- meriosclerosis. nately Utirik Atoll was spared the epidemic. A 54-year-old man in the comparison popula- Other than the poliomyelitis epidemic, the inter- tion died of asthma. No autopsy was done. val medical, history, both on Rongelap during the During the 10-year period, 10 deaths have oc- past 2 years and on Utink for the past 4 yea- did curred in the exposed Rongelap group, and 8 not reveal any epidemics or unusual diseases. Up- deaths have occurred in the comparison popula- per respiratory infections, gastroenteritis, and tion since 1957 (when this group was first exam- timgus and other infections of the skin predomi- ined). Table 3 lists the deaths with probable causes nated in the sickness inventory of the health aide. in the two groups. The annual mortality rate per Oniy a few cases of fish poisoning and sickness 1000 for the exposed group is thus about 12.2 com- from eating improperly prepared arrowroot were pared with about 8.4 for the comparison popula- reported. tion and 8.3 for the Msirshall Islands as a whole Deaths (1960). Poorly kept records made it difficult to get ac- Four deaths had occurred in the exposed group curate demographic data on the Utirik people. It during 1962 and early 1963: (1) No. 30, female, appeared, however, that during the past 4 veam 60 years of age. Died, July 1962, with a stated since they were last examined, about 5 deaths had diagnosis of cancer of the cervix. Previous exam- occurred in the older people and 6 infant deaths inations had shown progressive 10SSof weight and had been recorded. The deaths were due to vari- increasing hypertension. On the past survey, ous causes such as pneumonia, infant diarrhea, bleeding was noted from the cervical os and a and infections. gynecological checkup had been recommended Births but death occurred before @s was carried out. No autopsy was obtained. (2) No. 46, male, 84 yeats In 1962, 3 healthy babies were born to exposed of age. Died July 1962. Had history of arterioscle- parents and 5 to unexposed parents. In 1963, 5 rotic heart disease, a stroke a number of years ago, babies were born to exposed parents and 3 to un- and senility. No autopsy was obtained. (3) No. 26, exposed parents. male. 21 yearn of age. Died in December 1962, two ‘Dr. Hans Cottierof Brookhawn ~ational La~r=Or~ re- months afier a fall tlom a coconut tree. Death was portedon rhe histopathology. 14

Table 3

.Monality — Unexpcud

Subject .@e Subject .Age Year No. & = Probabk cause Year ‘‘4o. &sa Probable cause

1956 25 44M Hypmenaiv6 heart diseaae 1958 857 65 M Cerebral thrombosis(?) 1957 38 76 M Cvstmuy hart disease, djatts= 1959 854 55 F Infection urinasy tract, diabc= 1958 3L 9S M Acute varida 1960 933 56 M Pneumonia secondary to influen 1959 @ 60 F 1960 927 65 M Pneumonia seconc@’ to irduenz IW 86] 68F Diabetes, cancer cer.iq?) 1%2 *~F ~=’~ : ‘“ 1962 46 ,84M tirteriosclerotk+ W 1962 953 48 M Status asthmatieus i%2 Z& 21 M Brain damage “ Wlfromtme 1962 848 41 F Neurosyphilis(?) 1962 W- 75 F Fractured v ‘ . 1963 886 54 M .4A@?) 1%3 52 55 F Poliomye&,* 1963 57 107F ‘KM age’’(?)

●Not confirmed by autopy or biopy.

The birth rate for the past year was calculated obtained during the 1963 survey was complete, as in the previous surveys from the number of was not possible to calculate an accurate birth ra births per woman of childbearing age (15 to 45 for that group. However, the birth rate seemed years). There were 23 such women in the exposed be about the same as noted in other %larsha group and 39 in the unexposed group. (Not in- Island populations. cluded in either group were 4 unexposed women whose spouses were exposed males. ) For the 2-year Congonittd Anomalioa period in the exposed group 8 babies were born, Pi full-term stillbirth with conqenitai anomalie giving an average of 0.17 births per woman per (ectromelus) was born to exposed parents in 196 year; in the unexposed group 10 babies were born, This anomaly is not very uncommon, and in vie giving a slightly lower birth rate per woman (O.13 of the statistical evaluation the question of radi per vear). The births were ail full-term normal de- tion implication must be left open. One 24-vear liveries, except one case as noted below. oid exposed woman (No. 49) was operated on ~ review of the entire menstrual and obstetrical ectopic pregnancy in 1962. A case of congenital history of the women (examined in 1964) in the heart defect had been noted in a child born of e exposed and control groups is given in Table 4. In posed parents several years ago. This child died 20 exposed women there had been a total of 136 4 months of age. Specific genetic studies have n pregnancies, 19 women delivering 115 living been conducted on this relatively small ~pulation children for an average of 4.8 babies per woman and only routine examination of new births h for the 24 women in the group. The same fecun- been done. No unusual incidence of defects h dity was noted in the control women, 32 of the 39 been noted in the newborn. Some of the defec women having been pregnant 203 times and de- noted in both exposed and unexposed childre livering 189 living babiea, averaging 4.6 children include patent ductus arteriosus, congenital d per mother. The histories of the age of onset of formity of the hip, and congenital hypoplasia menstruation and development of menarche were the middle phalanx of the 5th finger. not too reliable, but the ages of onset for these events appear to be about the same in the exposed Miscarriages and Stillbirths and the control women. Except for the one ectopic pregnancy, no m Table 5 lists the births and fetal deaths by vear carriages were reported during the past 2-ve since 1954 of Rongelap peopIe. Since it was un- period. One neonatal death (at 1 month of ag certain whether the list of births on ~Ttirik Atoll due to infant diarrhea occurred in a twin born 15

Table 4

LMenstrualand Obstetrical Histoq, Adula, I%4

EqmUd Unexposed

Subject Age A@ Xo. Subject .+ & No. No. at men. at meno. NO.prcg. live births No. at men. at meno. No. pg. live birth

1 40 12 12 826 7 6 5 12 13 5 4 829 12 7 6 13 48 0 0 832 13 6 6 14 9 9 835 12 7 7 18 12 13 12 841 14 7 7 24 12 2 ~ 843 13 6 6 28 58 10 10 8M 13 12 11 34 35* 14 10 851 54 10 10 43 4 4 852 40 0 0 45 13 11 9 858 49 3 3 49 13 6 3 859 50 9 6 51 1? 2 0 865 13 10 9 58 64 12 10 867 18 9 9 59 41 ~ 1 893 15 13 11 60 45 o 0 894 45 0 0 61 12 2 2 895 17 63 44 13 10 896 13 3 3 64 12 10 9 898 45 4 4 66 13 0 0 908 54 15 14 67 i3 0 0 916 14 14 a 70 14 2 2 922 14 11 11 71 16 1 1 928 47 1 1 78 13 5 4 929 46 0 0 81 15 1 1 932 14 3 3 934 13 0 0 936 3 3 938 14 6 4 941 53 11 10 942 13 0 0 945 13 1 1 951 14 7 7 956 12 957 46 ~ 1 965 15 o 0 970 47 0 0 982 14 3 ~ 991 54 1 1 lcol 13 7 6 1042 17 6 4 1043 14 1050 18 1 1 1052 13 5 3

Av. 13.4 48.6 5.7 4.8 13.8 48.5 5.4 4.6

Total subs. (14) (7) (24) (24) (28) {13) (39) (39)

●Hystercctomv; not included in survey. 16

Table 5

Births and Fetai Dcat& by Y=

— Cbildrcm 70FrqllanClu Live ba ~ F Mscarria@ terminating-ti misctige y= women@ 15-45 To~ P_ci= ~D’ 100 0 0 o 1 19 1 17 1954” 4 i 1 20 6 5 33 1955 0 4 2 20 6 4 m 1956 2 0 3 21 5 2 43 1957 4 4 6 22 14 8 29 1958 2 3 2 22 7 5 1959 4 1 10 10 9 5 1960 ’24 0 0 6 6 2 4 1961 23 1 25 4 3 0 3 1%2 24 1 17 6 5 2 3 1963 27 0 1 1 0 0 1964’ 26 2 u Nlt.woaaD 2 22 9 7 6 1 1956 29 2 18 11 9 4 5 1957 30 1 11 9 8 5 3 1958 30 1 10 10 9 4 5 1959 29 2 20 10 8 5 3 1960 29 0 0 8 8 6 2 1%1 29 1 17 6 5 4 1 1962 30 0 0 2 2 1 1 1%3 32 0 0 3 3 2 1 1964’ 32 CIncluda only children concehd after March 1, 1954. *Includ~ stillbirths and nconatd d-~. ‘%Audcs data only through March 1964. ~~cludea nonex~ funah mated to ex~ ~i=.

Table 6

%mmary of PrcgnancY Termtitti Data (women aged 15-45) 1959-1963 1955’-1958 Uncx@ Expacd’ Une# ExpOtd (30 femalu) (36 femal=) (22 females) (31 f-ales) —— —— Incidence ‘O Incidcne % IncidmtCC % Incidena ~ 21 58 19 c1 17 56 12 54 1 3 women giving bh to livingchildren 1 3 2 7 5 23 39 wanmwithm iuxriagms but no live births 36 11 37 14 5 23 11 ~ Wancn with no recorded prcgnanb 5 17 6 9 41 5 16 0 0 1 3 Women with one or mm= rnmpc 3 14 2 6 5 15 4 11 Women with two or mom m~ap’ 13 41 8 22 Total mbcarriaga’ CInclud= stillblfi and nconaml deati. “Includa m~ Occuning after March 1, 1954. ~Includca noncx~ females mad m ~~ real=. Table 7

Physical Findings in Ronge&p and Utirik Adult Populations

1963 * 1%4 ““a,,.w 1*

R’CUR C.. ~ s, — RS”C UR” C -.e 4575524785 2646 “*H. 1 Adenopathy 1 3 ;~ ‘“ - . ~& S’ ~~:. Anemia, anemic 42 3 6=” whcssis,scolioais “ : ; 2 5$ir .+rte~ pcrip&r4 Sssikl 14 1 612- & ‘-s%= ArteriowlertX@ ~ .s ‘if 1 1 1’ LdmpIakia ? moderate to ~ Lz 10 3 6.,:$ -,.Z%E 1+ Asthma k Z.L Liver, palpable “ ..” ~“” +423 Aurictslar fibriliatitsts with * :.f& * MYOC=di~ da= ‘q my-al damage 1: insufficiency (EKG) 1101 1 10 Bradycardia 11 “ 1 Obesity 7945 Bronchitis ,,-,, . . . 4 3: 4 Cbteoanhritis &@ LM- tt3- $ Cardiac ess&r~ = 3“ 3 i Pwyak, .:,,+ -% ““‘ .,1 . .. * 1 ~T . ..- cardiac ssi%msr’””- - 4 .+ ,,.=4- “. Cervical -W bkding..’ 8 14 4,45 1 ce~~!~. ,4+5-53’ .. . : 22 *;A L6~2”26“ 2 2 ‘: 20: ; +%+ .* ..~atic hypcrtmphy ““5 ~ 7 : ..2. 4:. ?rG$t?is!* ~w.:i ,:’ ,,=., .-. . *- .-.. *&z * .-, 5th finger 23 23 Rheumatic heart d~ease 1 d) @YC&Ct@ttS 1 1 Senility 41 3 c) shortened left thumb 1 syphilis(?) arrested 2 ~ 11 f) flexion deformity, fingem 1 1 Thyroid enlargement 1 1 g) small 4th toe 1 Tinca circinata or vemicolor 1 3 Cyst, Bartholin 1 Tonsiiar hypertrophv, tonsiiitis 1 3 Cyst, ovarian 1 Tumor, benign 5813-I Cvmxcle ~ 2 Ulcer, leg 1 -.. u- ~.. -*-., Diabetes ,. 7 7 111 ~: DupuytruD* ntracntrc ‘“: 1 LJtcntaesslqet@F& &@idq? 2 Epi~ = ~a- 1 Uterw~ “ 4 L Furunculoda ‘- s 1 Varicocele : “-%* ~: r * 1 v~- ~: ~ ,, Gvnecnsssam@: ;1 11 “ “:t- 1 ~ ...= Hailux ~ * 1 Vttili@ -. :F-:.. - Hemomhoids .s, .s. 3

gnae: C. Rongelap une~ U., ~suspeet: f f. ,, -..’ ~,...... &. ~.-+ ,, *.- . exposed p-, the ‘Zi~. dix 7 cOn~@@@’ on eqch with tong ., in@%iili@ .&’-” Appendti 8-&nt&ns such in- posed par “ - ,,ddescribed ~. T4#hsJ5 and 6 for_@ “* : ~ ,~ld. 3 . +% ‘ show the i-, of misc&&es and ~s in the exposed ,~--czmsparison populat”msu: on a Ad@ E&d@tMQlsc .-:

‘e%~zlo%l!2U2~2%l!35rt.he in3Z+7*&_~E$23 Utirik populati=wcre not reliable. “~-,’ j:~~

.,,-:.. PHYSICAL EXAMINATIONS ‘: zc$s$5&i:z: percentag~-o~’olde~ peopie in this group. There The major findings on physical examinations are was a slightly increased occurrence of cervical ero- Iisted in Table 7 for the adults and Table 13 for sion and laceration in the exposed women. The ex- 18

@ FOUP ab dIOWedan increase in kypho- formation on body proportions and estimates of scoliosis, which is probably also due to the age fat and muscle of various ethnic groups. His analv- factor. A slightly increased incidence of prostauc sis of the Marshallme data compared with manv hvpertrophv was found among the exposed males. individuals in other racial groups revealed that This will be given particular attention in the next the young ,Marshallese adult male (age group 20 survey. The unexposed population slightly ex- to 39) appeared outstanding in regard to muscle ceeded the exposed in incidence of infknmatoty development. Table 8 shows a comparison of the diseases such as adenopat.hy, bronchitis, and phar- anthropometnc data on males of the Rongelap yngitis. There are no obvious reasons for this dif- group and other groups. In contrast to the men, ference. .No maiignant lesions were detected in the data indicated that the women were either either the exposed or unexposed groups. Pa pani- physically immature or had lost a considerable colaou examinations on vaginal secretions revezded amount of lean tissue. These data as summarized several that were suspicious of malignancy. These by Dr. Behnke are presented in Appendix 9, women will be checked carefidly on the next survey.

Antbspamgtric Stvdka Podiatric Examinations During the 1963 and 1964 physical examina- Chiidtan Examined 1963. During the 1963 tions, anthropometric measurement were ob- survey, a total of212 children were examined: 35 tained on Rongelap adults examined ( >19 yearn children exposed on Rongelap, 32 children ex- of age). These measurements included height and posed on Utirik, 35 children born after the fall- weight, and circumferences of shoulder girth, out to exposed parents, and 120 controls. biceps, forearm, wrist, chest, abdomen, buttocks, In the Rongelap “exposed” group, twochildrett thigh, knee, calf, and ankle. Dr. Albert R. Behnke, examined in 1962 were not availabie in 1963. Jr. * has been analyzing such data to provide in- Three other children were transferred to the adult study (Table 9). The previous medical survey of ‘l%e L’nivenityofCaliforniaMedicai Center,San Fran-. children on Utirik had been done in 1959. Of the

Table 8 ;,:~..+ti ~ ~ti ~- ~ ; i.,. ‘:3 !T, - “:sm’of11 - r .4ge,’ years Height, drn Weigk, kg ‘fi% ci&nferencmb c~~XII&F .< Rongeq(@-. , “’ .,,;; 20-39 16.25 60.7 2.936 481 197,9 R-(2) . 41-68 16.11 66.0 3.071 603 196.4 Turia - ~ 19-32 16.93 64.6 ?.986 59’2 198.3 ..,~tlg Greeks 18-30 17.05 67.0 3.033 603” 198.8 Italians 19-44 +:. 17.07 -+ 70.3 3.106 613” 1974 - y*j$)3 %on xuci~w 13%100 18-22 78.5 3.220 627 194.7 Lankenau 34 20-40 $?.71 75.3 :+- 3.171 616 194.3 Navy 31 -* .20-50 “*.: :.,> %~~.s .:. y’-& 626 193.9 18-34 593’ 194.8 ::: g’*+ ~ 17.56 624” 197.2 ..*1845 “ ‘:X$ 3:164 Phi&del@z%%l@ 22 1T.m v. ,~~ 3.165 615 194,3 Baltimom indigents 20 57-93 16.47 ‘ 6(L9T’- 2.927 578 197.5 Berkeley(l) 458 14,5 16.61 /56.8 2.794 541 193.6 - (~, 4s 15,3 17.11 - 61.1 2.893 561 193.9 R&&naman - - 17.40 70.0 3.078 600 194.9

‘Morc tb -of subjects are included in age range. “The 11 &b&renees are girth of the shoulders, ckst, abdomen (average of was, omphalion pcrimetet-s), buttocks, rhigh; biceps, t’brearm,wrist, knee, calfi and ti. Note the small variation in the K vaiua. ‘Lower abdominal (omphalion) circumferences only were measured. ‘Forearm and knee circumferences calculated. Table 10 Table 9 Utirik Pediarnc Poprdation Exposed Rongelap Children Examined in 1963 .%mpla Examined in 1959 and 1963

Total number examined in 1962 30 TotaAnumber exauned in 1959 w Not seen in 1963 (Na. 44, 84) ~ Not expo8ed, not examined in 1963 IO Transfen-ed to adult study (Nca 61, 76,81) 3 Not expmed, examu-md in 1963 ~ Total number efined in 1963 25 Expmed, not examined in 1%3 14 -. graduated to adult study 7 Table 1I Expmed, not examined in 1959 but examined in 1963 3 Control Pcdiitric Population, 1963 Totai number examined in 1963 32

Total number examined in 1962 % Table 12 Not gcen in 1963 14 Graduated to adult study j Children Born After Fallout to Experi Parents Not seen in 1962, seen in 1963 3 Total number old controls seen in 1963 85 Toral number examined in 1962 37 New babica added 4 ,Notseen in 1963 3 New controls added (Ebeve ) 29 Died since 1962 1 New con~ls added tRongelap) ~ New babita added in 1962 ~ Total number controls examined in 1963 - 1~o Total number examined in 1963 35

Table 13

SUmmarf of Phvwcal Findings 10Cluldren, 1963 and 1964

Control ExpQaed Born before Born after Yonex& barn Rongelap I Jan 1955 1Jan 1955 of exposed paremx Utirrk 1963 1964 1963 1963 1964 1963 1964 1963 1964

?Jumber examined 25 22 30 38 44 51 57 35 +1 Active skin lesions 1 1 0 2 3 13 8 4 3 .%ienopathv 5 2 0 4 1 9 5 2 5 Palpable liver o 4 0 0 5 1 + 1 11 Palpable spleen o 0 0 0 0 ~ 0 0 ~ Upper respiratory intkction 8 0 1 ‘1 8 8 3 5 4 Blood pressure taken 19 22 29 30 43 3 28 ~ 19 Hvpertenaion 1 0 0 0 0 0 o 0 0 Acute otitis media 6 1 1 2 6 ‘2 5 1 4 Chronic otitia media o 0 0 0 o 1 1 1 1 Molluscum 1 0 0 1 0 7 6 3 7 Thea vemicolor ~ ~ 3 5 0 1 1 0 0 Vitiligo o 1 0 ~ 0 0 1 0 0 Wans 3 0 2 1 ~ 4 2 2 5 Papillorna 1 0 1 1 0 0 0 0 0 Cheilcais o 1 1 0 0 0 0 0 1 Excoriation of lip o 0 1 0 0 1 0 2 0 Black spots on tongue ~ 1 0 1 2 0 0 0 0 Geographic tongue o 0 0 0 0 1 0 0 0 Conjunctivitis o 0 0 0 0 1 1 1 0 l%yroid noduie- 1 3 0 0 0 0 0 0 0 Tracheotomy scar 1 1 0 0 0 0 0 0 0 Thoracotomv scar I 1 0 0 0 0 0 0 0 Pes excavatus o 0 0 1 0 0 0 0 0 Infantile eczema o 0 0 0 0 0 1 0 0 files “mIunq o 0 0 0 0 1 0 3 () Svstolic murmur (grade 2) o 0 0 ~ 0 2 1 0 3 EWraaywoics o 0 0 L 0 0 0 0 0 Spotted enamel on permanent teeth o 1 0 o 0 0 0 0 0 .Amsocoria o 0 0 0 0 0 0 0 1

●Subjects .Yo. 17, 13%z-year-old female: No. 21. 13%~-vear-old female: and No. 69, 13%~-year-old female. 20 potentially available total of41 children from the Table 14 1959 survey, 29 were re-examined in 1963 (Table 10). In the group of 60 children examined in 1959, History of PoiiotnyetitisAmong Children there were 12 who because of their ages could not of Study Populati~ Rongelap and Ebeve have been exposed either directly or tn utsro to the Subjects with positive history but no residual involvement Eaiiout radiation; two of these i 2 were re-exam- at time of examination ●: ined in 1963. More than one-fourth of the es- ‘d Na. 102, 105, 113, 120, 126, 127,930, 1012, pediatric sampie on Utirik was iost to foiiow-up 1025, 1031, 1040, 1504 between the two examinations. Subjeets with paitive history and with residual involve- ment at time of examination: The fluctuations between examinations in the Na. 96, 98, 103, 106, 110, 870, 901, W3, numbers of controi children and of ofipring of ex- 1030, 1037 e Paents are shown in Tabiea 1i and 12. The 29 children added to the controi group were ran- ●One subject, No. 84, who had a history of poliomyelius domiy selected from the Ebeye schooi population was not examined. to provide an additional group comparable in ages to those Rongeiap chiidren who were exposed during infancy and eariy chiidhood years to the the 1964 survey (Nos. 95, 96, 98, 106, 870, 901, faliout radiation. Unfortunately, a study of the 903 ). In several instances, the degree of involve- biographical information on these new subjects ment appeared less than in the previous year. indicated the existence of the same uncertainties The increase in palpable iivers in exposed and regarding actual chronological ages that had been controi groups during the 1964 examinations is encountered before. Verification or correction of thought to rault &om variation between &diarnc the birth date on each of the children wiil be re- examiners. Liver enlargement exceeded 2 cm quired before the data can be utilized for com- beiow the right costai margin in only two chiidren, parative purposes. and in the remainder the iiver was paipabie at the Children Examined 1964. During the 1964 costai margin oniy. In ail but one additional cate- survey, 22 exposed children, 41 chiidren of ex- gory in Tabie i 3, variation was considered to be posed parents, and 10i controi children were ex- within iimits expected in sequential examinations amined. The decrease in the number of exposed of any pediatric age population. chiidren examined in the Rongeiap series from Thyrw”d Nodulos. Of particular interest was 1958 through 1964 results from temporary move- the development of thyroid nodules in three giris ment of subjects to other atoils and to graduation 9 and 10 years after exposure; two were 13 and of chiidren from the pediatric to the adult study. one was 14 years of age at the time of detection. The increase in number of children of exposed These girls were in the higher dose group in which parents examined resuits from new births. there were 29 children ( <18 years of age) exposed; Results of Physical Examinations. The inci- 17 of the 29 were girk with 6 girls in the iO to 15- dence of abnormal physical findings in the exposed year range. Of 75 unexposed comparison chiidren, and control groups of children is summarized in 37 were girls, and 21 of the giris were in the age Tabie i 3. In general the heaith of the chiidren range of 10 to 15 years. No thyroid noduies were seen during both surveys was good. Respirato~ noted in this group (oniy one diffuse thyroid en- infections and skin infections were infrequent. The largement has been detected in an unexposed nutritional status of ail chiidren was adequate, the aduit). A small noduie was first detected in one growth patterns were consistent with those seen in of the girls in 1963, and noduies in the other two previous years, and the height increments for the were first detected in .March i964. No lymph node period were comistent with the previous group involvement was grossiy evident. The individuals trends. were hospitalized and two had compiete thvroid-

During the epidemic on these atoiis, 24 children ectomies and the third a partial thyroidectomv. ● in the study developed poliomyelitis. Residual Grossly the glands had a “bobbiestone” appear- weakness of muscle groups was evident in i 1 of ance with multipie hard nodules and were at first these children at the time of the 1963 examination (Tabie 14). Seven children continued to show ‘Captain C.A. Broaddus(MC) U.S.iN. at the U.S. Yavai residual paralysia of varying degree at the time of Hospiul in Guam pcriimnedthe surgery. .

,-% ,.

..

@

Figure 10. GrosI picture of sectioned thvroid gland born 14-year-old .MarshaA1~ girl \ ANO.69) showin’g nodules.

Figure 11. Microscopic section (10 x ) of thyroid gland from same case ~ in F@me 10. These changes are char-

acteristic of all three caacs. L~ote the multiple, discrete nodules with wide variation in size and growth pattern. Some nodules consist of microfollicuiar tissue and othery of colloid cysts. while still others show hvpcrpiasia with papillary infolding of the epitheliums. 22

1 1

—

,60+

80u MEDIAN STATURES 1956-1963 _ GII?LS BORN AFTER FALLOUT p’ _ CHILDREN oF EXPOSED MEOIAN sTATuRES 1954-1963 GIRLS PARENTS _ ExPOSED :---.; 7o1- $H&~DN~ESN OF UNEXPOSED - Oo1- /., ~--d CONTROL

,, 1, I I 7 I 2 3 4 5 6 5 6 7 9 9 011 12 13 14 15 16 17 34 CHRONOLOGICAL AGE (YRSI CHRONOLOGICAL AGE (YRSI

Figure 12. Figure 13

I I I I ,’ I 1 I I

17r3~ 7

F --Q /, !60+ L

j SO* . , ‘A

u 110 ,“ ~ ,40- I ,’ 5 ,Vl 3“ 100 , ~ 83+ I / 5 ~ — :’ 90 I Zop 4

, / ! MEOIAN STATURES 19513-1963 80 ‘ !10 [ 80YS EIORN AFTER cAL.2u- ‘cHILoRENOF EXPOSE3 ~ BOYS MEOIAN STATURES 1958-1963 1 PARENTS — ~ EXPOSED 1 70 >--oc H, LDREN OF JNEx Pf3SEJ 100 1 ~---o CONTROL PARENTS

) l:l’ III! I I I 1; I I 2 ; 4 5 5“ 345s7a 9101112 13141 s1617 CHRONOLOGICAL AGE !YRS) CHRONOLOGICAL A= [YRs~

Flgurc 15. Figure 14. MEDIAN WEIGHTS 1958-1963 MEOIAN wEIGHTS 195 E-1963 1 ,,, jl{ I \ ,,1 I ,1 illi I BOYS

140+ _ EXPOSED >–+ CO NTFOL /7

120+ / /“~ ,“/!

—

!, ,, , ) I I ( 20+- G4 6 8 10 ,2 ‘,4 6 AGE [Y EARS I

! 04’ Figure 17. 6 a 10 :2 14 16 AGE (Y EARS I

Figure i6. were in boys 12 and 17 years of age and one in an adult woman 4 i years of age. The nodules ap- thought to be malignant. Sections of the tissues peared grossly similar to those described in the were reviewed by a number of pathologists,* all &t-age girls in this report, and these cases will of whom agreed that the nodules were not malig- receive study and treatment. nant and resembled in many respects adenomatoid Growflt and hvdopmont W&s. .Analvsis of goiters seen with iodine deficiency, with its charac- the statural data from the 1963 survey indicated teristic regenerative rather than neoplastic prolif- the persistence of the trends previously reported. eration. However, in the lhlarshall Islands, where .%sshown in Figures 12 and 13, no difference was fish and sea food arc mainstays of the diet, iodine apparent in median statures between the exposed deficiency is not iikelv and goiters are rare. Figure and control groups among girls and between girls 10 shows a picture of the gross appearance of the born to exposed and girls born to nonexposed nodules and Figure 11 shows a microphotograph parents. * .~mong the bovs, however, retardation of one of the glands. The likelihood of these nod- in statural ,qrowth of the exposed group between ules being radiation induced is discussed in the the aqes of ~ and 12 years as compared with that Summarizing Discussion. The two girk who had of th~ control group was again noted [Fiqure 14). complete thvroidectomies developed signs of hvpo- The difference in median statures between boys parathyroidkm which responded to treatment. born to exposed parents and those with non- Parathyroid function returned in ,No. 17, but No. exposed parents was also evident in 1963 iFig- 21 still requires therapy including thyroid extract. ure [5). This difference has been attributed to the In the third case (No. 69) only a partial thvroid- fact that the boys in the group with exposed paren~ ectomv was done, and she requires no therapy. were. on the average, 4 months younger than the ?/oTE: During the 11th-vear survey now in pro- boys in the group with nonexposed parents. gress ( ~March 1965) 3 new cases of thyroid noduies No statistically significant differences were noted in the exposed group have been detected. Two in body weight curves between exposed and con- trol children (Figures 16 and 17). In skeletal mat- “Sectionsof tissuewem reviewed and reported on b. Dra.S. tVarren..VCW EnglandDeaconessHmpita~:GH. W~k. .~m~ uration, the trends reported in the previous studies ForcesImmureof Pathology;C.J. Stahl, L’.S.Naval Hospitalat Guam; H..\, Johnson. BrookhavenNatlonai Laboratory,and *Dr. K..M. Griffithof the M.D. Anderson Hospital did the S. Lindsav, Umvemtv ofCalifornia.McdicalSchool. sransmal analvses. 24

(7-year and 8-year surveys) have persisted. In comparison with the Greulich and Pyle standards, the skeletal development of Marshailese children was retarded at the same chronological age levels. In addition, the exposed children were less mature than control children. The retardation was most prominent among thaw exposed during infancv to the fallout radiation (see Figure 18). Skeletal age values during successive examinations of this par- ticular group of children are shown in Table 15. These data covering the period since 1958 are being published in detail elsewhere. 1‘ Complete tables of anthropometric measurements on the Marshahse children dating back to the earlv sur- veys are presented in Appendices 11 through 16,

Ophthalmological findings Ophthaimologicai examinations were carried out in 1964 on 68 exposed, 45 children of exposed, i-- and 190 people in the comparison population; a total of 303 people. AS noted in previous surveys, there w“asan in- creased incidence of large corneas and enlarged tortuous retinal vessels and a lower incidence of Figure 18. Brothers. Marked retardation in staturai myopia, strabismus, amblyopia ex anopsia, reti- .gmwth is shown by the older (shorter) brother (No. 3, on nitis pigtnentosa, retinobiastoma, and congenital rheright) who was expoud at age 18 months. The younger glaucoma. by 21 months (No. 83, on the leh) is taller by 13 cm. Tk retarded boy showx no evidence of hyperthyroidism or The incidence of arcua senilis is higher in the skeletal diaeaae clinically, other than markedly delayed Marshallese than in similar age groups in the 09eou8 maturatkm. United States, which is in keeping with the gen-

Tabie 15

Skeletal Age Development in Chiidren Born kween July 1952 and Februaq 1953

Skcletai age (S.A.) values ats~ “veexamination, years Age at Subjeet No. Sex exposure, months C.A.9=4 yr C.A.=6 p C.A. =8 yr C.A. =9 yr c..+. = 10~

2 M 16 3% 4% 6 7% 814 3 M 17 z% 2% 3 3 3 5 M 16 3% 3* 3% 3% NE* 6 M 16 3 5% 6+4 8% 9 65 F 15 z% 31/$ 6 6?$ 8 33 F 20 5 6% 9% 10 .W 54 M 12 33A NE 9$$ 10 11 955 F c* NE NE 10 10 10% %2 F c NE NE 7!4 7% al{, 980 F c NE 6% 8% .NE NE 996 F c NE NE 8% 10 1014 814 M c NE W 8 9 10

“C.A..chmnologiai &; NE=not examined; C.not cxpacd (mntml). 25 erai observation that the Marshallese age faster The incidence of pinguecula and ptervgium is than Americans. The incidence was higher in the high in the Marshall [siands, and also slighdv exposed group (3670 ) than in the unexposed group higher in the exposed group than in the unexposed ( 19!7.). However,*ecent anal@s of aging criteria (see TabIe 16). It has been postulated that the did not show any significant differences between higher incidence in the exposed group mav be re- exposed and unexposed groups. Iated to contamination of the conjunctival sac Though diabetes mellitus has a moderately high with fallout material at the time of the accident. incidence in the lMarshall Islanders, only one case The incidence of abnormalities of the crystalline of diabetic retinopathv was noted. This is in keep- lens is greater in the Marshall Islanders than in ing with the observation that the onset of diabetes in similar age groups in the United States. Further- the Mat-shake occurs largely in older individuals. more, the incidence of such abnormalities was

Table 16

Ophthalmological SurVw. 1964

Children Exposed of expxed Comroia

No, J?o No. V. No. %

Number examined 68 45 190 Anisomria 1 1.40 1 0.52 Anterior staphyloma 1 1.40 Arcus Seniiis 25 36.70 37 19.+6 &yll Robertaa pupil 1 1.40 Chalazion 1.05 Choroiditis (old, healed with scars) ~.~o 1.57 &njunctivitis 1.40 COmeal pigment 2.80 Comeai scar 4.20 2 1.05 Drii.sen 1.40 Duane’s syndrome 0.52 Lens: Polychrotnatic sheen 18 26.50 21.37 Opacities & cataract: prexnik i 1.40 1.57 senile 12 17.60 10.64 Aphakia 2 2.80 0.52 @rosy, eve signs of 1 1.40 0.52 Macuiar degenemtion I 1.441 1.05 MoUuscum contagioaum 0.52 .Mefanoma of iris 1.05 Melanoma of cmsjunctiva 1 1.40 Nystagtnus ~ 1.05 Pinguecula 11 16.33 17 8.44 Pterygium 20 29.40 38 19.98 Proptosis I 0.52 Phthisis bulbi 1 052 Positive Rhomberg 1 1.40 1 0.52 Retinal arteriosclerosis 4 6,00 9 +.68 Retinal scan 2 2.80 5 2.60 Retinal hemorrhage 1 1.40 Strabismus: Internal i 052 Externai 5 7.30 2 1.05 Seventh nerve weakness 1 2.2 1 0.52 Vkreous opacities 3 1.57 26 somewhat greater in the exposed group in 1964 Tabie 17 than in the unex+sed comparison population. These abnormalities consist of polychromatic Residual “Beta Burns” sheen, lenticular opacitiea of all degrees, and cata- Subject racts: The polvchromatic sheen was noted as the No. Age sex Data earliest lens change and varied from a few fine granules in the earlier cases to large granular 2 12 M Roughening and pigment variation on front of neck. Several pigmented plaques in the more advanced cases. These plaques maculea ACF. * Perianal depigmen- were situated on the posterior lens capsule in the tation. zone of specular reflection. The earliest cases 3 11 M Mottled pigmentation both axiliae. showed yellowish granules which in some cases Pigmented area behind left ear. appeared slightly darker with a “beaten brass” 11 60 M Pigment changes ieft .xCF, dorsum color. ,% the granules coalesce into a plaque, firw right toe; pigmented nevi axdla. greenish and bluish hues appear - hence the name 17 i3 F Scarring and pigmentation left .\ CF. poivchromatic sheen. Whether the poivchromatic sheen seen follow- 20 17 M Pigmented patch back of neck. ing irradiation has unique and specific charac- 23 14 M Pigmented maculcs left axilia. front teristics is will a debatable question. Some inves- of neck and chest. Dcplgrnersted spots tigator contend that similar appearing changes shafi penis. can be detected in patients with retinitis pig- 24 23 F Slight pigment variation on from of mentosa and the early stages of cataracts which neck; several pigmented macules domum left foot. might be a complication of endogenous ocular or systemic disease or intoxication. Such polvchro- 34 55 F Slight roughening and pigmentation back of neck. Moies on front of neck. matic sheens were seen in 2170 of the unirradiated Rongelap group and 26.5?. of the exposed group. 39 25 F Siight roughening and pigmentation back of neck; pigment variauons and This difference is thought to be too small to impli- slight hyperpigmencation dorsum cate irradiation exposure with any degree of cer- right foot. tainty, particularly in view of the slightly greater 49 25 F Numerous pigmented maculcs both number of older people in the exposed group. The sides of neck and a few on arms and incidence of lenticular opacities was also slightly ACF. greater in the exposed group ( 19%) than in the un- 54 11 M Mottled pigmentation and dcpig- exposed group ( 12?o). mentation on front of neck. Only one child (an 8-year-old female) com- 59 44 F .Mottled pigmentation and deplg-- plained of defective night vision. This was thought mentation on back of neck. to be due to vitamin ~ deficiency, since there were 63 46 F Slight rugoaitv and pigmented ridges no pathological changes in the fitndus ofeither eve. on back of neck. Several years ago 12 children were encountered 64 40 F .Mole back of neck; slight plgmenr who had great difficulty in seeing at night. These variation and a few macuics front of children responded promptly with vitamin .4 neck. treatment and dietary changes. 65 il F Pigment variation and roughening Only two cases were noted with corneal pigment- front of neck. ation, previously seen in three cases ( 1962). This 67 24 F Depigmented wars dorsum left foo~. pigmentation was characterized by a fine, dark, linear streak of pigment lying close to or on Bow- 75 22 F Slight pigmented area dorwm rlqhl first me. man’s membrane in the horizontal axis between the limbus and pupillary edge. It is believed that 78 47 F Numerous peduncuiatcd moics on sides and fi-crrttof neck. these changes may have been induced from beta radiation contaminating margins of the eyelids at 79 49 M Pigmented and depigmented scar posterior surface left ear. the time of the accident. There were several findings which mav be re- ●.ACF= anmcubitaf fossa. sidual to the poliomyelitis epidemic of 1963: two cases with 7th nerve weakness involving the lids; since that tinx (see Figure 21). Histological study two cases of anisocoria (unequal pupils); and an of a biopsy of one of these hmions showed it to be increased incidence of strabmmus. a typical benign pigmented tsevus. The residual changa tithe skin oft. Mar- Itaaial “bta -S” shallcse who had sustait@@#@te “~t~ % ~s” have shown neither fiasum d@% b~ ti the Persisting residual effects of %eta burns” were tiectcci areas as w=@,cj@nic radfl~ d~a- found to be present in 19 people, 6 children and t.itistis+orevidence [email protected] change. OnIy one 13 adults. These are outlined in Table 17. The .@&WCda f+ ofdqxcia of the occipital skin changes consisted of hyxtosis, and ha of & scalp as a ruiduum of epilation. Figure varying -= Ofa~p~y$ *; ~d pi@%X ~ 2’2~ histological residual changes in a lesion aberrations (see Flguru 19 d *. ~- c- :~t 1 : after exposure.” were slight in most of the pople. The dev4M-. ..’ ment of lentigo-like and papular pigSSSent@:*’> : r y;$ “f lMORATORY EXAMINATIONS nevus-like lesions in areas of previous “beta burt@~. - * was first observed several years ago, and thq-.~ ..;. : lesions appear to have been increasing slightl #“’WW&M ,i. - Summary tables of hematological data are pre- %ted in the tables and graphs in the text, and Figure 22. Section ofskin hvm “teta burn” area on back of raw data on the individuals are presented in the neck of 56-yearald woman (No. 34) at 10 yean after ex- pause (100 x). Note atrophy of epideti with narrow- appendices. The more heavily exposed Rongelap iog of wramm granulaum and linger-like projections of rete pegs. Might atrophy of the sweat gland ducts u also “Dr. David A. Woodof the Uoiwxsi~yof Caliiomia Medical &nur, Sm Franci-. @ ~ ~~~ ~+~~ praent. 29

Table 18

Mean Levels of Rongehp Peri@ed Blood Elcmenu by .@c and .%x, 1963 Mono. — WBc New. Lymph. Plate. (xlO-’) ( x 10-3) ( x 10-’) (Xlo-’) ( x 10-J)

Malc39-15v 3.25=0.59 (9) 0.44 (9) 287= 66 (9)’ 8.47 Y2.18 (9) 3.92=1.31 (9) Rongelap ex~ 3.19 (1) 0.06 ( 11 (1) 6.64 (1) 2.79 (1) Ailiignac ex~ 194 3.89=1.17(11) 0.24(11) 9,2052.88( 12) 4.5751.83(11) Utirik CX@ 419= 93(12) 0.30( 14) 8.3732.90( 14) 4.07=1.96(14) 3.27=1.11(14) Rongclap unex~ 2863 78(14) Females 9-15 w 3.31=0.80 (8) o,~4 (8) WH 78 (8) 8.5032.49 [8) 4.42=3.09 (8) Rongelap ex~ 2.97 (2) 0.22 [‘2) (.2) 7.15 (2) 3.69 (2) Ailiignae Cxp=d 225 o,~g( 15) 9.0132.66(151 4.81 =2.04( 15) 3.33ao.94( 15) +02=116(14) 0.26( 16) Utirik expo=d 8.82= 2.2!3(17) 4.12=1.&( 16) 3.86= 0.7~f 16) Rongelap unex~ 3732 99(17) Males >15-40 W 2.82a0.89( 1t ) 0.19(11) 198= 71(11) 15.58c1.49( 11) 3.27 ~0.74( 1i ) Rongelap expo=d — — — — — AiIingnae ex~ (3.27(10) 6,jj=l.47(io) 3.42~0.76( 10) 2.55 30.85( 10) Utirik cx~ 342* 78( 10) 0.28(21) 7.77=1.44(21) 4.07=1.86(21) 2.96ao.90(21) Rongelap unex@ 294= 66(21) Females >154 w 0.29( 14) ~ 8.02=2.18(14) 4.35=1.33(14) 2.86=0.84( 14) Rongclap exe 297=127( 14) (,4) 0.25 (4) 227 7,96 (4) 5.45 (4) 2.05 Ailiignae Cxpoxd (4) 0.21(16) 7.17=1.39(16) 3.96z1.35( 16) 2.67 aO.66( 16) Utirik exposed 410= 97(16) 2.83=0,78(23) 0.22(23) 7.65a l,47(23) 4,23=1.34(23) Rongclap unexd 294= 66(23) Mares >40 w 2.99=1.@4 (8) 0.15 (8) 2143 87 (8) 6.33z1.24 (8) ?.88=0.59 (8) Rongeiap cx@ 2.46 (4) (3,27 (4) 6.38 (4) 3.23 (4) AilingnaC ix- 245 (4) &~’2(19) 6.88=1.85(19) 3.49=1.09(19) 2.80=0.91(19) Utirik ex~ 344= 73( 19) o~of23~ 6.65z1.40(23) 3.17=0.99(23) 2.85 a0.67 (23 ) Rongclap Unex@ 294= 66(23) Females >40 YT 0.18 (7) 5.82=0.60 (7) 2,86=0.58 (7) 2.56=0.63 (7) Rongelap exb 238= 98 (7) 2.37=1.20 (5) 0.35 (5) 7.2031.60 (5) 3.83=0.57 (5) .Ailingnac exd 249= +7 (5) 3.o7 =0.92( 15) 0.22( 15) 7.08=1.30(16) 3.47& l.13( 15) Utirik cx~d 356= 90( 16) 2.98=0.94( 19) o,~6( 19) 7.21=1.40(19) 3.67=1.20(19) Rongelap uncx@ 318= 94(19) Mala <9 W 5.15=3.04( 16) 0.39( 16) 10.60&3.49( 16) +,49=1.19( 16) of CXp-d p=n~ 3745 95(15) j.~9=1.87(29) 0.40(29) 10.91z2.87(N) ~.+0=1.82(29) Of unex+ p=n~ 375=119(29) Females <9 VT 6.07= 3.OQ(18) 0.55( 18) 3436A 87(18) 12,20&l.92( 18) 4.76=1.92( 18) Of exm=.f p.=nu ;.31=1.60(22) 0.36( ’22) 3835101(21) 1o.15=2.5O(2’2J 3,83=1.23(22) of ULX+ p=nu ~ Serum Baao. RBc ( x 10-’) Hgb., g protein. g ( x 10-’) (xlO-’) Hct., T

Malu9-15yT 429=45 (9) 13.830.5 (9) 7,7=0.5 (9) 0.79 (9) 0.74 (9) 39.1= 2.0 (9) Rongclap ~ (1) 12.4 (1) 7.5 (~) 0.0 (1) 36.0 (1) 3?7 Ailingnae cx~ 0.60 (1) 4.42=~3~12) 7.6z0.3[ 12) 37.9=2.1(12) 15.0=1.2(12) Utirik exposed 0.50( 11) 0.38(11) 7.8=0.4( 12) 39.4=1.4(14) 433=34( 14) 14.150.7(14) Rongelap unex~ 0.69( 14) 0.44( 14) Females 9-15 w 449=34 (8) 13.9= 0.9 (8) 8,0~0.4 [8) 0.48 (8) 0.46 (8) 39.5= 2.0 (8) (q) Rongclap cx# (2) 15.0 8.0 (~) 0.0 (21) 41.0 (2) +35 Aihngnae exposed 0.28 (2) 1+.051.0(15) 7.9=0.4(14) 0.40(15) 38.032.1(15) $27=29(15) Utirik exposed 0.53(15) 7.9=0.5( 17) 38.3=2.7(17) 424=40(17) 13.7=1.6(17) Rongelap unexp=d 0.48( 16) 0.35( 16) 30

Tabie 18 rcont’d)

.Mcan Levels of Rongelap Peripheral Blood Elements by Age and .%* 1963 — Euain. Baao. RBC Serum ( x 10-’) (x 10-’) Hct., % ( x 10-+) Hgb.. g protein. g

Males >15-40 y-r Rongelap exposed 0.28( 11) &p5(ll) 45.5=2.4( 11) 458=47(11) 16.1=1.3(11) 7.6=0.3( 10) Ailingnae exposed — — — — — — Utirik exposrd 0.26(10) 0.48( 10) 44.6=2.5(10) 464)=34( 10) 16.2=0.7(10) 7.6=0.4(10) Rongelap unexpoacd 0.40( 21) 0.30(21) 45.7=4.7(21) 473=32(21) 16.1=0.5(21) 8.0=0.4( 21) Femal= >15-40 vr Rongelap exposed 0.52(!4) 0.25(14) 37.9=4.8( 14) 409=64( 14) 13.2=1.8(14) 7.8=0.5( 14) .Aiiingnae expoud 0.19 (4) 0.32 (4) 37.3 (+) 406 (4) 12.9 (4) 7.7 (4) Utirik exposed 0.32(16) 0.17(16) 37,1=3,6(16) 405=41(16) 13.2~1.4( 16) 7.6=0.4( 16) Rongelap unexposed 0.35(23) 0~3(23) 38.3=2.8(23) 421=39(23) 13.651.0(23) 7.9=0 .6(23~ Mak >40 yr Rorqelap expused 0.31 (8) 0.08 (8) 41.3= 5.4 (8) 410=58 (8) 14.5= 0.5 (8) 7.6=0.4 (7) Ailingnae exposed 0.35 (4) 0.06 (4) -$4.0 (4) 469 (4) 15.8 (4) 7.6 (4) Utirik exped 0.34(19) 0.28( 19) -i,3=~.2( 19) 428=36(19) 14.8=0.9( 19) 7.8~0.4( 19) Rongclap unexposed 0,36(23) 0.37(23) Y2.1~3.3(23) 429=47(23) 14.7=0.5(23) 7,9=0,5(23) Fcrnales >40 vr Rorqelap cxpcued 0.21 (7) 0.09 (7) 38. Iz2.5 (7) 376338 (7) 13.3= 1.4 (7) 7.8=0,2 (6) Aihngnae exposed 0.62 (5) 0.23 (5) 38.0= 2.6 (5) 403=41 (5) 13.9= 1.1 (5) 8.4=0.4 (5) Utirik CXfWSed 0.32(15) 0.25(15) 38.0~3.1( 16) 405=28(16) 13.8=0.8(16) 8.1=0.6(16) Rongeiap unexposed 0.27( 19) 0.37( 19) 38.3=1.7(19) 393=29( 19) 13.7ao.9( 19) 8.0=0.5( 19) Males <9 yr Ofexpmed parents 0.56( 16) 0.19(16) 36.5=3.0(16) 438=64( 16) 12.6=1.1(16) 7.3=0.4 (6’) Of unexpcud parema 0.79(29) 0.58(29) 36.9=2.4(29) 434=30(29) 12.5= Io(29) 7.3=0.2 (5) FemaAa <9 yr Of exposed parentx 0.79( 18) 0.23( 18) 36.8=2.2(18) 424*32( 18) 12.8=1.0(18) 7.7 Of unexposed parents 0.64(22) 0.03(22) 37.6=1.7(22) 415=24(22) 13,0~0.9(22) 7.9–03-- ::;

‘Includcx 2 children exposed UIuttro. “Standard deviation and numimr of people in group. ‘Includes 1 child expoeed m UWO.

Table 19

Mean Levels of Rongeiap Peripheral Blood Elemenm by Age and Se- 1964

Plate. WBC Neut. Lvmph. (x 10-3) (x 10”’) Ix 10-’) ( x 10-’)

M& IO-15yr Rongdap expoad 374= 35 (9)’ 8.01=2.10 (9) 3.31=1.27 (9) 3.78=1.17 ,9) - =P=d 328 (1) 7.55 (1) 3.17 (1) 2.87 (1) “Rongdap unexposed 389=158(15) 11.13=4.70(15) 5.96=5.03( 15) +.17=1.22(15) Femala 10-15 yr Rongelap expoxd 398=110 (6) 7.53=1.10 (6) 3.39=0.52 (6) 3.34=1.06 ~5’) Ailingnae expmed 454 (1) 11.08 (1) 4.87 (1) 4.87 (1) Rongelap unexpoacd 397=106(18) 9.87=3.00( 18) 4.74=2.25(18) 4.00=0.94( 18) Males >1540 vr Rongelap exposed 287= 78( 11) 8.12~2.10( 11) 3.9051.44(11) 3.42=1.08(11) .\iiingnac exposed — — — — RongeIap uncxpsed 3372104(24) 9,4033.40(24) 5.10=2.73(23) 3.45=1.15(23) 31

Table 19 (cent’d)

Mean Levels of Rongelap Peripheral Blood Elements by Aqe and SeA 1964 — Plate. WE NcuL Lymph. (xlO-’) ( x 10-’) ( x 10-’) ( x 10”3)

Females >15-40 yr Rongelap exposed 3722 73(15) 8.2531.90(15) 4.32=2.13(14) 3.31 30.96( 14) AiIingnae expxd 382= 95 (5) 6,80=1.60 (5) 3.04=1.18 (5) 3.19ao.77 (5) Rongeiap unexposed 382~11(3(2g) 9.16=2.00(29) 5.29=1.87(29) 3,11=1.11(29) Males >40 yr Rongclap exposed 331~126 (8) 7.83=2.00 (8) 3.60=1.20 (8) 3.48~i .22 [8) Ailingnae expoxd 323 (4) 6.59 (4) 3.03 (+) 3.03 (,4) Rongeiap utmxpmed 348~114( 19) 7.75a l.30( 19) 3.93a l.14( 19) 3.06=0.78( 19) Females >40 yr Rongelap expc+ted 346~~59 (6) 8.06=2.20 [6) 3.7452.02 (6) 3.53=1.18 {6) Aiiingnae exposed 441=148 (5) 8.06=2.00 ( 5) 4.32=0.91 (5) ‘2.8031.15 [.5) Ronqelap unexposed 360= 99( 20) 8.29= 1.9 ~20) 4.01=1.+1(20) 3.60a I.45i 20) -Males

Mono. Eosin. Bax). Ix 1O-J) (,x 10”’) (xlO-’) Hct., ?0 Hgb.. $

Males 10-15 yr Rongelap cxpscd 0.19 (9) 0.68 (9) 0.76 (9) 40.4= 6.1 (9) 12.5= 0.4 I,9) .Ailingnae exposed 0.45 ( 1) 0.98 [ 1) 0.80 ( 1) 37.0 (1) 12.1 11) Rongelap unexped 0.31(15) 0.66(15) 0.26(15) 37.4=1.7(15) 12.5a0.8( 15) Femaies 10-15 yr Rongclap exposed 0.10 (6) 0.65 (6) 0.38 (6) 39.5= 2.4 (,6) 13,3a0.3 (6) Ailingnae exposed 0.33 (1) 0.89 (1) 1.10 (1) 40.0 (1) 14.0 (1) Rongelap unexposed 0.21(18) 0.88( 18) 0.38( 18) 38.3*2.5( 18) 12.4=0.8( 18) Malu >15-40 yr Rongclap exposed 0.25(11) 0.43(11) 0.46( 11) 43.8~5.5( 11) 14.731.0(11) Ailirtgnae exposed — — . — — Rongelap unexpmed 0.26( 23) 0.57(23) 0.50(23) 46.1a3.1 (24) 15.2a i.1(24) Femaics >15-40 w Rongelap exposed 13,~4(14) 0,37(14) 0.35( 14) 40.0=2.3( 14) 13.1=0.7(14) Aiiingnae exposed 0.20 (5) 0.33 (5) 0.36 (5) 38.0= 6.1 (5) l’2.3a2.5 (5) Rongeiap unexposed (3.2~(2g) 0.49(29) 0,50(2!3) 37.35 A.5(29) 12.4=1.6(29) Males >40 yr RongeIap expoxd 0.26 (8) 0.-!8 (8) 0.39 (8) 43.032.7 (8) 13.5= 1.9 (8) Ailingnae exposed 0.13 (4) 0.39 (4) 0.30 (4) 43.0 (4) 14.5 [+) Rongelap unexposed 0.20( 19) 0.47( 19) 0,48( 19) 41.6=2.6( 19) 14.0=1.0( 19) FemaAa >40 yr Ron@ap expmed 0.09 (6) 0.65 (6) 0.53 (6) 37.3% 3.9 (6) 12.7al.4 (6) Ailingnae exposed 0.11 (5) 0.76 (5) 0.82 (5) 38.3= 1.8 (5) 12.7=0.7 (5) Rongeiap unexpeacd 0.23( 20) 0.40(20) 0.63(20) 39.6=1.0(20) 13.0=0.6(20) .Ualcs <10 vr Of expmed parrots 0.23(21) 0.73(21) 0.63(21) 36.6=2.5(21) 12.1=1.1(21) Of unexposed parems 0.28(33) 0.66( 33) 0.38(33) 37.3=2.4(33) 12.1=0,9(33) Females <10 yr Of exposed parents 0.32(20) 0.76(20) 0.38(20) 34.953.7(20) 11.5=1.+(20) Of unexposed parents 0.23(24) 0.62(24) 0.TO(24) 36.8=2.4(24) 12.1=1.0(24)

‘Includes 2 children exposed m uttro. ‘Standad deviation and number of people in group. 32

gTOUp who received 175 rads are designated as ~EUTltOPH3LS. The neutrophil levels increased “Rongelap exposed,” the Rongelap peopie who slightlv at the time of the 9 and 10-vear surveys in received a smaller exposure of 69 rads as “Ailingnac both exposed and comparison populations. At 9 expoacd, ” and the larger unexposed comparison years the neutrophd levels were about 5’% lower in popul~tion of Rongclap as “unexposed.” Because the exposed than in the comparison group, but at of the small number of people in the Ailingnac 10 vears they were about 20% lower. Neutrophii group, their data were not treated as My as those levels are shown in Figures 23 through 29. The for the Rongelap groups, and are briefly summa- neutrophil deficit was greater in the exposed rized in a separate paragraph. The Utirik data younger age groups ( <40 years). The exposed arc summarized separately also. Because of certain older age groups ( >40 years) did not share the difTercnces noted in age and sex groups between deficit as much as has been noted in the past (Fig- the exposed and the unexposed, in addition to the ures 26 through 29). comparisons of mean levels for entire groups, LYMPHOCYTES. Lymphocyte [evels were slightly comparisons are also made of age and sex groups. higher in the exposed and unexposed groups dur- Ages 9 to 15, 16 to 40, and >40 years for each sex ing the 9 and 10-year surveys. In contrast to the are compared. 8-year survey results, the lymphocyte mean levels The hematological data are summarized in showed little difference between the exposed and Tables 18 and 19 and in Figures 23 through 49. unexposed groups during the 9 and 10-year sur- In Appendices 1,2, and 3 are presented summaries vey-q however, some individual lymphocyte counts of the mean blood counts of the exposed popula- were lower in the exposed group. Lymphocyte lev- tions ant! of the various comparison populations els are shown in Figures 24, 25, and 30 through 34. since exposure in March 1954. In Appendices 4 and 5 are listed the individual blood counts for 1963 and 1964. In Appendix 6 basophil counts . CxP05sn9 KMs Fosr EXP03URS . LUEXPOSCO are presented. . Exmsm,r!Msw MAXIMUMoSPRSss@4 . Rongoiap Population. LEUKOCYTES. Mean levels of leukocytes in both exposed and compari- son populations at 9 years post exposure were in- creased over the 8-year levels, and the 10-year levels were higher than those for either of the two preceding years. The exposed group had only slightly lower leukocytes than the unexposed ( - 4%) at 9 years, and at 10 years, lower by 9%. Most of the dilYerence was due to lower neutrophil levels in the exptxcd group (see Figure 23). Figure 24. Cumulative percent distribution curves for 10, . !1, 1 I . I [ neuuophils, lymphocyt~ and piatelem. 1963. ‘*I [ ~ f W4 I Q- * A“*?

g~p;fi

TIME AFTER ExPOSURE OL 2.0 40 60 3.0 .20 4002040% Figure 23. Mean neutrophil and white blood counts of NEuTS XIO-l LW4PHS * 10-3 P,-ATE~-s , @-< exposed Rongelap pcop~e&om time of exposure through 10 years post exposure. Stars represent mean values of figure 25. Cumulative percent distnbucion curves comparison population. for neutrophils, lymphocytes, and piatelers, 1964. 33

EOSXNOPHSU,MONOCYTES,ANDBASOPHIM. The between the exposed and unexposed groups. Fig- levels of these cells were not remarkably different ures 40 through 49 demonstrate this point. between the exposed and unexposed groups and STATISTtC~L ANALYSIS OF RONGELAP BLOOD were similar to the levels in past surveys. DATA OVER PAST FOUR YEARS. These analyses PLATELETS. - The platelet levels in the 9 and are in progress, and the following represents a 10-year surveys both revealed greater deficit in preliminary report by Mr. Keith Thompson of exposed males than in exposed females. Compared Brookhaven National Laboratory. with the unexposed groups the males had 20% less “’A factorial analysis of variance of unweighed in 1963 and 12??0less in 1964, and the females 770 means was made for each of four blood compo- less in 1963 and 2’% less in 1964 (see Figure 35). nents: plateleu, white blood cells, neutrophils, and In the scattergrams (Figures 36 through 39) and lymphocytes. For these preliminary analyses, the the accumulative distribution curves (Figures 24 population was stratified into four factors: vears and 25) the differences are clearly shown. ( 1961, 1962, 1963, and 1964), sex, exposed Ron- ERYTT-SROPOIETSC ELEMENTS. As in the past SLU- gelap versus nonexposed, and age ( 5 to 15, >15 vevs no significant differences were noted in the to 40, >40). Thus, for each of the blood compo- red biood counts, hemoglobins, or hematocrits nents, main effects and interaction effects were

S.0 r 80!

WALES !%3 MALES S64 70+ . TO* I . ‘c+?””””

. 9 1, 20 L I0203040W 60 T.9090 AGE [ ym,sl

Figure 26. Neutrophil counts of exposed Rorqelap malex F@ure 28. Neutrophil counts of exposed Rorqelap males plotted against age. Solid line represents mean level of plotted against age. Solid line represents mean level of unexposed male population, 1963. unexposed male population, 1964.

9.ot 1 8.0 ,,, . . FEMALES 1%3 ; FCMALCS :964 70+ 1 ?ol- 6.01- . , I . 5.ot ● ●

. ● . 10!- * ● “ . ● ● . . !\j 2.0~ I .1 1 201,0 20- ~ ; & ~ “; ~. & 1020304050 60~80~ AGE(VWS) AGE (years)

Figure 27. Neutrophil counts of exposed Ronqelap fe- Figure 29. Neutrophil counts of exposed Rot-qelap fe- males plotted against age. Solid line represents mean males plotted against age. Solid line represents mean level of unexposed female population, 1963. level of unexposed female population, 1964. computed to obtain information about the effect 7 of radiation over time in relation to sex, exposure, 31- . L -+ and age. 6F “A generally similar pattern was observed in L– -i ! these analyses for all four components. The vari- 41- * ** . ation among years was always highlv sigmficant, largely because of an increased count in all four

0— . I components in 1964. This annuai difference has oa 24 @ 56 -2~ 23456 ”33,0 been commented on in previous reports. Differences 3AYS ‘JO YEARS 11M E AFTER EXPOSURE existed in 1961, 1962, and 1963, but these were not chronologically consistent among the com- Figure 30. Mean lymphocyte counts of exposed Ronge. ponents. lap people from time of exposure through 10 years post “A clear-cut and highly significant decrease in exposure. Stars represent mean values of comparison all four blood components was observed for the ex- population. posed population compared to the nonexposed. There was also a highly significant decrease in

7.0 t 50+ . MALES 1%3 < I MALES S64

. . &ot ● . I 4.0+ ● 7 ,’ SD!-*. . ,A “. “

1, ● 4.0 p ‘. ● I*-O ,

lot .“ ● . I ● I : . ● I 2.or . “ -1 1 ,11 1.01 ,0 ~. J J I 506070 s090 I \ 1 1.0L AGE [ y@0~8) 10 20 30 40 50 60 70 ‘8090 AGE !ywn ) Figure 31. Lymphocyte counts of exposed Rongelap males plotted against age. Solid line represents mean F@c 33. Lymphocyte counts of exposed Rongelap level of unexposed maAepopulation, 1963. males plotted against age. Solid line represents mean level of unexpaed male population, 1964.

r \ ,’ ) 1 1 ( 1 ?.0 , I I ! FEMALES 1964 1 S.o + FEMALES S63 I 7 ● &o t + . . 1“

20 ● . t“ “* “ 2.0 r ●

l,, ~, ,. 1.01 I 1 I.0 10 20;40s06070 $o~ IO 20 30 40 so so 70 30 50 AGEIWors)

Figure 32. Lymphocyte counts of exposed Rongelap fe- Figure 34. Lymphocyte counts of exposed Rongelap fe- males plotted against age. Solid line represents mean rnala plotted against age. Solid line rcpresertcrmean level levei of unexposed female ppulation, 1963. of unexpcaed female population, 1964. 35

counts of all four componen~ with incrc=ing age FE!A4LES 1%3 . ● 50 r at the time of radiation. There was no evidence . at the 5% level of any sex difference for any of the blood componenu except platelets, for which the . male count was~ignificmtly lower ( 1?0 level) than the female count. -i “There was no evidence at the 1% level that any of the two- or three-factor interaction (years, sex, exposed versus nonexpd, age groups) were ,- ● significant. For lymphocytes there was evidence ● ✌✌✎

at the 5‘% level of an interaction between exposure ION 10 20 30 40 S060708030 anti sex, and for neutrophils there was evidence AGE(yo.m) at the 5’70level of an interaction between exposw and vear. The four-factor interaction was treated Figure 37. Platelet counts of exposed Rongelap femalm as error, an assumption which app=red justified plotted against age. Solid line represenu mean level of upon examination of the variances. Since the~ unexposd female rmpuiationt1963. data are being further analyzed, no interpretation as to biological significance of the above interac- MALES !%4 tions is justified at present. ” ~~ L

●

● O ● 1 , ( 20- ,~-~ -330 . aa24’SOS67~ 234 56 ,, . .40 YEARS JAYS 10’ 90 w ‘o 20 30 40 50 60 ~ TIME A=ER EXIW51JRE AGE‘years1

Figure 35. Mean platelet values of exposed Rongelap Figure 38. Ptatelet counu of expmed Rongelap real= people from time of exposure through 10 years post ex- plotted against age. Solid line represents mean level of posure. Stars represent mean vsdues of unex~d com- unexpo9ed male population, 1964. parison population.

ml I ,4 I 1 :1 FEMALES 1964 1 WA-Es 1%3 . - . SOY ml- ● + -0 50+ ●

+~ : 1“ . 30+ “ . . . ● . ● *. I 20 r

\o’ ; 607030~ 10 20 so 40 ~ AGE[ymr$l

Figure 39. Platelet counts of exposed Ronge!ap femal= F@e 36. Platelet counts of exposed Rongelap real= plotted against age. Solid line represents mean level of plotted against age. Solid line represenu mean leveI of unex~d female population, 1964. unexpo3etf male population, 1963. 36

50! 1 \ , xl , I FEMALES 1964 ; MALES1963 1 E . L

451- .

$: .”..

!ij40k2-- ● 351- . .

Figure 43. Hematocrit values of exposed females plotted Figure 40. Hematocrit values of exposed males plotted against age. Solid line represcnu mean level of unexpcd against age. Solid line represents mean level of unex~ female population, 1964. nude population, 1963.

! ,8rl*l I 1 1 I 501 ,’ 1 \ i . MALES 1963 ~ . FEMALES 1963 )7L. . . ; F k 45* ●

4 g 12: ! d .- ~ Ilp

‘0 I -1 I I 1 I I t , , 1 9~ 30L ;0 ;0 ;0 ;0 ~o 60 70 80 90 !0 20 30405060~80 w AGE ( wan) AGE[years )

F@re 44. Hemoglobin valua of exposed males plotted F@re41. Hemattit valua of exposed females plotted against age. Solid line repre$enu mean level of uncxpmd ag~t a~. S&d lie re~nts mean Ievei of Unexb male population, 1963. female population, 1~

1 18r \ 1 I ! so, , , , . . FEtiLES 1963 j MALES 1964 ~ 17~ - . . . 16,L I 45+ ● “ . •1 . 1s+ ; . . ● .“ i? ““ . . . 14 . . !. :* ● . . ● .* gul “ 13 7 . a .0 ● ● a. i2![~ . i 2 u- . i -1 11~ -1 4 . I .!1 I I 1 1 ,, h I \ 91 ‘ , 10 30405060mw 90 30 80 90 20 10 20 30 40 so 60 70 AGE(yeor$) AGE [y*0r3)

F@re 45. Hemoglobin values of exposed females plotted Figure 42. Hematwrit values of cxpoaed males plotted ~g~~ age. S&d line represents mean level of unexpos~ against age. Solid line represents mean level of unex~ femaie population, 1963. male population, i964. 37

1, ) \ 7 I . M&ES )963 ● 500!-””

i3’m”J. -1 I . ,0p 340r

300 I 1 1 , \ ,! 1020304050 6070 6090 AGE(years)

...... 1,, . . . J. —-. — Figure 46. Hemoglobin values of expoacd males plotted rqure W. Klw values Otexposeo reams plottea agamsz a-t age. Solid line represents mean level of uncxposed age. Solid line represents mean level of uncxposed male male population, 1964. population, 1963.

I I\ FEMALESI* I FE?4ALES 963 6+ Xot “ . .-e . 15P -. 460+... .”..

● ‘. 10r 340Y .

3cm‘ 02030405060 7080~ AGE ! y~OfS]

Figure 47. Hemoglobin valua of exposed fcmaks plotted Figure 49. RBC values of exposed females piottcd against against age. Solid line represents mean level of unexposed age. Solid line represenw mean level of unexposed femaie female population, 1964. popuiauon. 1963.

Ailingnae Population. The i 6 people in the was of interest that the plateiet counts for all age ,Ailingnae population that were examined during groups averaged considerably higher in the Utirik these two years showed blood counts similar to people than in the Rongelap unexposed population. those of the higher dose Rongciap group. The 10- The explanation for this is not apparent. The etyh- vear platelet counts in the Ailingnae women were rocytea, hemoglobin, and hematocrit levels were considerably higher than the previous counts; the about the same as in the unexped Rongelap people. reason for this is not apparent. The blood data on Childmss of Exposad Pormta. Blood councs of this group of people are summarized in Tables 18 children of exposed parents compared with those and 19 and Appendix 2. of the children of parents in the comparison ppu- Utirik popul~”em The people of Utirik Atoll lation showed n; significant diffe~ences. These who had been exposed to a very low dose of radia- data are tabulated in Tables 18 and 19 and Ap tion (an estimated 14 rads of whole-body gamma pendices 4 and 5. During the 7th and 8th-vear radiation ) had leukocyte, neutrophil, and lympho- surveys these children had shown slightlv lower cyte counts of about the same levels as seen in the levels of leukocytes and piateiets compared with unexposed comparison population of Rongelap children of unexposed parents. This difference is (Tabie 18 and Appendices 3 and 4). However, it not apparent at this time. Figure 50. Bizarre mitosis in a mvelocyte.

Figure 51. Binucl-td normobl=. 39

Bars. Marraw Examinations row examinations will be carried out in both these cases during the 1965 survey. The differential counts of bone marrow aspira- tions on 6 individuals, 4 exposed and 2 unexposed, Rod Coil Mass and Pkxssm Volume Studies are listed in .@pendix 18. The differential counts During the 1961 and I %2 surveys blood volume showed that in 3 of 4 exposed persons there was an studies were performed on a group of Marshallese alteration in the mveloid-ervthroid ratio mani- subjects and on a small number of Caucasians fested by an increased number of red cell precur- who had been living on the islands for one year or sors. in addition to hyperphsia, abnormalities of longer, Sodium chromate labeled with Cr” was chromatin material with doubie nuclei and in- used to tag the erythrocytes. With body weight as creased numbers of mitotic figures were seen in a criterion, it appeared that 15 of 23 subjects, both the normobiastic series (Figures 50 and 5 I). One LMarshake and Caucasian, showed a significant of the exposed (No. 63) and one of the unexposed reduction in red cell mass and~or plasma volume. [ANo.948) showed increased Ivmphocytosis of 33?0 In order to establish the relationship of blood and 27T0 respectively. This was reflected in the volume to lean body mass tritiated water was peripheral blood counts in which the total number administered orally to each of 21 Marshallese of leukocytes was normal but the lymphocytes subjects during the 1963 survey. In addition, de- were increased to51 Voand 56~0. The significance of terminations were made of red cell mass and blood this finding remains obcure, but repeat bone mar- volume by using Cr51-labeled sodium chromate.

Table 20

Total Blood and Red Ceil Volume Data (WT. =grow weight; TBW = total bodv water: FAT=tht as ‘o gross weight; LBM=kan bodv mas RCV=red cell voiumc: BV =blood volume)

Subject “ RCV/’LBM, BV, LBM. No. WT.. kg TBW. I TBW, % FAT, % LBM, kg RCV, 1 BV, I rid/kg ml kg

822 54.54 38.1 68,8 +.4 52,1 1.402 3,~60 26.9 62.6 832 46.36 25.0 53.0 ?6.4 3+.1 0.849 2.358 ?4.9 b9.2 836 56.36 35.3 61.7 14.3 48.3 1.+28 3.320 29.6 68.7 838 66.13 41.7 62.2 13.6 57.1 2.108 4.053 36.9 710 841 66.81 31.9 47.0 34.7 +3.6 1.150 3.196 ?6.4 73.3 873 61.36 43.2 69.4 3.6 59.1 1.670 3.631 28.3 614 881 68.63 32.8 47.1 34.6 44.7 1.996 4.247 44.7 95.0 882 54.77 39.9 71,8 0.3 5+.6 1.131 3.426 20.7 62.7 885 61.81 41.0 65.3 9.3 56.1 1.760 3.825 31.4 68.2 895 55.90 29.0 51.5 28..5 40.0 1.070 2.488 26.8 ~~.~ 916 63.63 32.6 50.4 30.0 44.5 1.091 3.031 24.5 68.1 928 57.27 29.4 50.5 29.9 40.2 0.927 2.505 23.1 62.3 932 46.30 26.2 55,7 ‘22.6 35.8 1.274 2.963 35.6 82.8 .- 938 40.00 22.0 54.1 24.9 30. i 0,886 2.331 ?9.4 ,,, -4 942 57.72 27.6 +7.1 34.6 37.8 0.860 2.150 22.8 56.9 959 6000 32.2 52.8 26.7 44.0 1.151 2.877 26.2 65.+ 960 38.63 24.8 63.1 12.4 33.9 0.774 2.150 22.8 63.+ 1007 71.36 +1.2 56.9 21.0 56.4 1.620 4.155 28.7 73.7 1043 4[.81 26.4 62.3 13.5 36.2 1.066 2.664 ?9.4 73.6 1501 66.81 +3.3 64.0 11.2 59,3 1,843 3.840 31.1 64.8 Jeton 63.18 39.8 61.9 14.0 54.-! 1,310 2.675 ?4. 1 49.2

.Av 33.5 1.303 3.102 28.3 68.2

AvBV(l) “iv ‘Cv f‘) =0.039; AvTBW(I) A. TBw ( 1) ‘“”@z Table 21 40 Protein Bound Iodine, 1963 and 1964

Subject No. PBI, y %

MAWWU.ZSERE.WDINGONRONGE- 1 9.4 6 7.9 2 0. 10 12.0 4s slRl- -! 14 8.2 / .“: 86 8.2 ~ F. MO@S\ / 17 6.8 ‘“ Y.””” I 21 a. I 69 10.2 865 8.2 AV 8.8

.MMSHALLSSE RESIDINO ON EBEYE’ 12 8.8 829 7.1 944 2.0 938 5.6 c- I REDCELLvOLWS 982 6.3 F, MoORE’ I 950 6.7 1005 7.9 I I OL I 1043 5.8 20 30 40 50 TOTAL ~OY wATER - Ii!cm AV 6.3

Figure 52. AMERICANS RESIDtNO IN M.MISN.UL ISLANOS AT LSAST1 YEAR After 4 hours, urine samples were collected and F.B. 6.2 lyophiiized, and tritium in the water portion was G.B.D. 5.5 RL. 5.0 counted in a Nuciear-Chicago liquid scintillation W.R. 5.6 counter. From these values of total body water, R.C. 6.1 fat was estimated by the formula ?O fat = 100 G.S.B. 5.5 -(% TBWI’O.72). The % TBW is total body W.?J.C. 4.+ water (in kg) as percent of gross weight. Lean AV 5.5 body mass ( LBM) was taken as the difference be- tween gross weight and fat (kg). Lh’fEDICALTsww The data are shown in Table 20. According to D.C. 4.7 Siri (personal communication) the values for total R.C. 4.7 body water, fat, or lean body mass are not differ- L.C. 5,1 R.H. 5.5 ent from averages for Caucasian subjects in the E.L. j.2 San Francisco area. Figure 52 shows the vaiues of L.M. ?.5 blood volume (Iitem) and red cell volume (liters) W.M. 6.0 plotted against total body water. Regression lines LJ. 4.5 4.2 drawn for Caucasians by Moore’3 and Siri (un- W.s. W.w.s. 6.9 published) d~lose that with the exception of one .4V 4.9 case the values of Marshallese fall far below those described by the authors. The average red cell volume for Marshallese is 28.3 ml per kg LBM as tions of blood volume and total body water in compared to 35 ml/kg (Siri, unpublished). Caucasians living in this area for one year or more. Whether these findings represent a genetic dif- Other laboratory studios ference or are che result of environment and/or diet cannot be stated at present. It is hoped that chromosome Shsdks. Microscopic examina- studies will be continued in 1965 with examina- tion of smears from peripheral blood cultures is in food, etc.). .4 difference bemveen the medicai team progr-, including chrom~me counts, enu~,era- who had only been in the Islands a few week and tion of aberrations, and karyotype analysis by the .Americans who had resided there for at least pate-up of photopph. A few dlcentic chromo- a yea is probably not significant. It is anticipat~ somes and certain other aberrations have been that this aspect of the problem will be further m- noted in the examined group, but insufficient con- investigated on the n~xt survey. trol material has been analyzed for any positive FOLICACID DETERMINATIONS. Foiic acid levels statemen= to be made at this time. were below or in the low range of normal in 29% Based on blood sugar deter- Diab.tk SU~oY. of the 129 Rongelap people tested. Fifteen per- rninatiom as part of the routine urine anaiy= and cent were MOW 4 mpg/ml arid 1690 in the border- fasting blood sugar determinations, it was found line range of 4 to 7 mpg/ml. The unexpod com- that 6 people had a diabetic tendency. The fol- parison population had slightly lower values than lowing had elevated fasting bid sugam (mg %): the exposed population. The generally low level ~0. 853, 247; NO. 893, 279; No. 936, 187; TO. of these Mand people is attributed to a dieta~ 991, 248; No. 1042, 180; No. 835 had a 3+ urtne deficiency of foods containing folic acid, mainly sugar but no blood sugar detertni-tion was done. leafy vegetables. The levels were not sufficiently As has been noted, the incidence of diabetes is low to result in any hematological changes or ap- fairly high in the Mmhailese. It is, however, of Daren[ clinical effects. The individual...- values for the type that develops in older peop~e since no ~olic acid are presented in Appendix i /. cases have been seen in younger peopie. THE .AG SYSTEM. The following statemenu PROTEIN BOUYD IODtFIE Serological Studies. were made by Dr. B.S. Blumberg*: “’The ser,a of Protein bound iodine levels DETERMINATIONS. patienw who have received multiple transfwlom were determined in =’erd group of VOP1e ‘ur- may contain antibodia against normal human. The groups included 9 L*The first exampie of such ing the pat two WJmeys. serum components. Mamhallese living on Rongelap Atoll, 8 Marshal- antibodia was reported in a patient (C.deB. ) who lese living on Ebeye Island (Kwajalein Atoll), 10 had received s50 transf~ions for the treatment members of the medical team. and ~ .Americam of a refractory anemia of unknown etiology.’3 BY who had been resichg in the Marshall lsian~ for means of the Ouchterlony double-diffusion tech- at least a vear. The results are presented in Table nique, it was shown that the antibody formed a 21. Again the Marshall= value are higher than precipitin with =55% of normal U.S. white and the Caucti- vahm. Though the number of sam- Negro sera. By twin, family, and population stud- ples involved is too small for any positive state- ies’” it was shown that the presence or absence ment to be made, the lower levels of the Marshd- lese living on Ebeye may have some meaning, since their environment is quite diRerent from that of the Rongelap residents (more westernized in

NCWYork C.rie%. %Pos. 70 Pos. Total No. Location Total No. Population 181 38 187 98 mngelap Atou 120 97 Micronesia 120 59 Maryland 149 99 us. white 149 68 203 93 U.S. Negro - 203 72 Greece 102 86 Greek 102 70 Peru 143 78 Q~hua Indian 143 91 SOUth Dakota SIOUXIndian of the reacting antigen was under genetic control. exposed and unexposed of ages <15 and >15 Individuals with a dominant gene designated A@ years, living on Rongelap, Ebeye, and Utirik. in single or double dose (genotypes .4g’,,4gA, Sr’O urine levels for 1963 and 1964 have not in- A.gA/Ag) were reactors [phenotvpe .Ag(a + )] and creased over the 1962 levels. In 1962, the mean those htimozygous for the recessive allele Ag non- %’” values from the individual adult 24.hr sam. reactors [Ag(a - )]. The antigen or antigens that pies were 12.45 pC/1 or 114 pC/g Ca. From these react with the antibodies present in the serum of values, on the basis of previous calculations, i ‘g the frequently transfused patient are serum low the body burden was estimated as 12.o m~C for density ~-lipoproteins. 1‘ A serum from a second adults and 28.4 m#C for children. On the same patient (1.M.), the New York antiserum, was aIso basis, the estimates for 1963 body burden levels found to react with a low density ~-lipoprotein. of SrgO are 11.3 mpC (adults) and 21.8 m~C Preliminary family studies indicated that reactors (children); and for 1964, 10.7 m#C (adults) and were homozygous or heterozygous for a second 23.1 mpC (children). As shown in Table 23, the gene, while nonreactors were homozygous for the levels of both Cs’3’ and SrYO are lower for the alternate recessive allele. Immunologic, genetic, people living on the uncontaminated island Ebevc and population studies showed that the lipoproteins at Kwajaiein Atoll. selected by the two antisera were antigenically Thus the return of the Rongelap people to their distinct and controlled by different genes. ” home island was reflected in annual increasm to “Sera collected km the inhabitants of Rongelap 1962 in estimated body burdens of Sr’O based on .Atoll in 1962 were tested with both the C.deB. urinary excretion values. The annual estimates in [anti-Ag(a +)] and the New York antisera. The mpC for adults were as follows: 2.0 in 1958; 6.0 in total results compared with thctse on several other 1959; 6.9in 1961; 12.Oin 1962; 11.3 in 1!363; and populations are shown in Table 22. There is a 10.7 in 1964. The present body burdens are about much higher frequency of C.deB. antiserum re- 5 to 6’% (adults) to about 10’% (children) of the actors and a much lower frcq uency of New York maximum permissible concentration ( MPC) of a~tiscrum reactors in the Rongelap population Srg” (200 mPC) for non-industrial populations. It than in U.S. whites and Negroes. The reasons for appears now that equilibrium with the environ- these differences are not known, but may depend mental contamination of SFO has been reached in on differences in past or present selective forces the people Iiving on Rongelap Island, and the which affect the balance of the Polymorphisms. previously estimated equilibrium value of 23 mKC “Because of the iower frequency of New York will not be reached. antiserum reactors, the Rongelap population was No bone samples were obt@cl from autopsy useful for family studies. From these studies it was material during the past two years for SrgO anal- tentatively concluded that reactors with the New ysis. Estimates of body burdens from previous York antiserum were either homozygous or heter- analyses of bone samples had shown fairly good ozvgous for a dormant gene, and nonreactors were correlation with thcoe obtained fhm urine analyses. homozvgous for its alternate allele.” In view of the paucity of the previous data on Radiachemical Anulysgs of th. Urine. Deter- CsL3’ urinary levels, it is difficult to interpret the minations of body burdens of gamma emitting present levels in terms of body burden. However, isotopes (principally Cs’3’ and Znu5) by whole- the levels are generally less than the mean 1958 hody gamma spectroscopy were not done during Cs’” urinary level of about 4 nC/1. This is in ac- the past two surveys. Data in 1961, by that tech- cord with the finding by gamma spectrographic nique, indicated that the body burdens of Cs’3’ determinations that the whole-body burdens of were not significantly different from those of two Csl° in 1961 had not increased. years before, and Znds levels had dropped by a Analyses of three coconut crabs for Sr’O and factor of about 10. It was decided, therefore, to Cs’” are shown in Table 25. Though the Ievels of defer whole-body counts until the 1965 survey. Srg” (pC/g Ca) are lower than in the crabs ana- Results of radiochemical urine analyses for Cs”: lyzed in 1962, they are stiil sufficiently high COne- and Srg” on 38 urine samples for 1963 and 27 sam- c~itate continuation of the ban on their consump- ples for 1964 are presented in Tables 23 and 24. tion by the people of Rongelap. It is interesting that The data are divided into the following groups: the Csiar levels are also quite high in these crabs. Table 23 .

RAochcmicd Urine Anaivsis for S#Oand Cs’”, 1%3

%’”. pC/1 C% g/1 SP”, pCig Ca CS’37,nC, I Group Subject No. Age .%x Sample .oL, ml

RONGUAP 19.3 ).072 268 6.73 818 12 M 790 UnexfX@fA W <15 6.4 .020 320 3.32 820 14 M 1180 12.0 .168 71 2.60 814 11 M 1490 .188 91 1.52 913 12 M 590 17.1 .117 98 2.68 912 10 M 1630 11.4 4.9 .012 408 4.69 815 13 M 550 5.9 .046 137 1.54 911 10 F 1050 +.1 .022 186 3.14 955 10 F 465 6.3 .035 180 ‘2.1’2 816 13 F 1050 4.69 12.5 .172 73 821 14 F 705 3.31 950 10.0 0.085 183 man 4.8 0.031 155 1.81 19 12 M 1160 EqXaed, age <15 5.6 .046 122 2.24 23 13 M 987 9.6 .031 310 6.11 69 13 F 987 .076 230 2.84 42 12 F 1060 17.5 .076 442 3.08 17 12 F 340 33.6 16.8 ,074 z27 1.10 8 II F 1150 248 2.86 947 14.6 0.056 wan 6.4 0.069 93 2.02 822 16 M 1280 Unapmcd, age >15 11.8 ,072 164 2.41 865 30 F 795 128 2.21 1037 9.1 0.070 Mem 7,33 NU 14.6 0.167 88 40 38 M 1.73 Exposed, -age> 15 875 9.1 ,218 42 7 4: M 0,57 1500 2.0 .040 50 41 53 M 1.67 6.3 .177 36 27 35 M 1400 6.9 ,038 182 0.48 14 34 F 990 2.58 8.9 .137 65 66 38 F 650 4.0 .015 267 4.45 39 24 F 530 7.96 725 7.2 .171 +2 18 30 F 2.68 15.3 .104 147 61 17 F 1025 3.27 933 8.3 0.118 102 wan 4.5 0.051 88 1,58 .4 2060 1.62 Pwi 3.5 .071 49 B 1820 4.7 .065 73 1.+9 c 1990 70 1.56 1956 4.2 0.062 Mean

75 0.65 Eazm 1400 5.9 0.073 Pcokf.f

UTIIUK (-aD) 8.5 0.149 57 0.95 2256 14 F 625 .* <15 1.9 .031 52 0.15 2251 12 F 350 0.55 487 5.2 0.090 55 marl [,26 ~,6 0.363 7 2168 28 M 730 0.70 Age >15 3.2 .178 15 2137 24 M 800 0.98 765 2.9 0.271 11 Mean

3.14 SOMX-Y 11.8 0.074 207 3.08 Rongdap, all <15 8.3 .114 107 0.65 Rongclap, au >15 5.9 .073 75 0.55 Ebcye 5.2 .090 55 ().98 Utirik, all <15 2.9 .271 11 U[irik, all >15 ‘M

Table 24

Radkchetid Urine t4nal@s for Se” and G’”, 1% — a’”, nc/1 Gcoup Subject No. Age 8CX sample VO1.,rrd Sfi”, PW ~ g/1 SF, @/g a

RONGWAP 0.165 136 6.90 13 M 22.4 Unexpmed, * <15 818 4.5 0.020 225 4.12 19 13 M 1280 12.0 Expoud, age <15 21.1 .071 297 69 14 F 490 261 8.06 885 12.8 0.046 Mean 2.97 9.0 0.114 79 822 17 M 2880 2.96 Uncx#. a& >15 6.7 .077 87 865 31 F 3260 7.4 040 185 3.62 896 24 F 2180 117 3.18 2773 7.7 0.077 Mean 2.94 6.6 0.028 ?36 15 17 F 1103 2.34 ExpOd, age>15 3.5 .035 100 41 54 M 1940 4.59 9.5 .230 41 40 39 M 2000 4.33 11.1 .206 54 7 46 M 1890 4.6 .069 67 3.55 16 49 M 1880 3.14 6.0 .122 49 50 MM 2100 4.52 8.7 .032 271 14 35 F 1580 6.40 14.5 .181 80 18 31 F 860 2.95 3.6 .083 43 27 36 M 1340 3.60 7.2 .200 35 59 MF 1000 98 3.84 1569 7,5 0.119 Mean 0.96 3.7 0.080 46 A 8920 2.94 Pooled 9.3 .107 87 B 2050 66 1.95 5480 6.5 0.093 Mean

EazYx 0.15 4.4 0.130 34 909 14 F 770 Uncxpad age <15 1.49 9.0 0.083 108 32 13 ~ 1160 3.34 ExpoaccLage <15 16.3 .189 86 23 14 M 285 98 2.41 722 12.6 0.136 Mean 0.030 117 0.08 34 F 1180 3.5 Unexpod, ~ >15 895 .130 66 2.80 35 F 2000 8.6 1,25 843 5.3 .052 102 893 46F 3680 95 1.37 2287 5.8 0.07 I Mean 1.17 2.4 0.092 26 28 78 F lm 1.86 Expo@lLagc>15 7,6 .078 97 39 SF 740 61 1.51 970 5.0 0.085 Mean

SUMMAXY ’219 767 1257 16.0 0.085 102 3.69 Rongclap d <15 1846 7.5 .1OI 76 1.99 Rongclap, ~1 >15 738 9.9 .134 81 1.45 Ebcyc, all <15 1760 5.5 .077 Ebcyc, ai1>i5 45

Table 25

&Isdysu of Coconut Crabn for SF and Cs’3’ — Per kg Total

Crab No. lhue .%=’,pc C9’”, pc C&g .3P”, pc cd”! PC -g Sfl”, w~g~

1 Liver 4,’4M 2,679 6.88 999 608 1.56 639 Exmkdetcm 172,502 94,074 198.39 68,285 37,239 78.53 869 Wade (edible) 5,757 4,994 6.57 1,708 1,482 1.95 876 RemairmgSoti parta 5,631 4,470 6.36 516 410 0.60 858 70,703 39,292 81.71 71,508 39,739 82.64 865

2 Liver 4,428 2,287 5.80 571 295 0.75 764 Exoskeleton 123,318 95,724 197.75 45,287 35,154 72.62 623 .Muscle (edible) 3,980 5,757 5.50 937 1,355 1.30 723 Remainiq sot?parts 5,711 3,414 6.92 497 297 0.60 825 Total crab 57,766 45,318 91.94 47,292 37,101 75.27 628

3 Liver 8,650 5,431 10.21 335 502 0.48 847 Exakelemn 146,956 143,758 187.90 30,817 30,146 39.40 782 Muscle (sdible) 6,010 12,716 7,74 978 2,069 1.26 776 Remaining soft parta 4,316 6,475 6.23 211 316 0.30 692 64,847 66.234 83.09 32,341 33,033 41.44 780

Summarizing Discussion MORTAUTY

There were 10 deaths in the exposed population HEALTH STATUS over the 10- year period. of these, two deaths were Medical evaluation of the health status of the due to malignancies. Neither of these could be exposed Rongelap people over the years since the ascribed reasonably to radiation exposure. The accident haa revealed about the same incidence of somewhat higher death rate in the exposed group illness and disease aa in the unexposed population is partly ollket by the higher proportion of older with the exceptions noted below. General health people, those >65 years of age being 20% in the and nutrition has continued to he satisfactory and exposed group and only 7% in the unexposed comparable to that of the unexposed comparison group.This mortality rate is also higher than in Poptdation. Annual hematoiogical follow-up the Marshalkse as a whole, but not significantly studies have revealed that the levels of white so. Evaluation of effects of exposure on longewty cells and platelets of the peripheral blood in the in diis group must await hue findings. exposed group have never quite reached the levels of the unexpaed comparison population. This w= AGING again demonstrated in the 9 and 10-year surveys and can be readily seen in the accumulative distri- No specific aging studies were carried out dur- bution cutvcs (Figurca 23 and 35). ing the past two surveys, but attempts were made Bone marrow examinations of a few individuals during several previous sunevs to put on a quan- at 9 and 10 years post exposure showed a reduced titative basis various criteria of aging (skin elastic- myeloid-er@roid ratio with slight increase of imm- ity, skin looseness, hand strength, blood pressure, ature red and white ceils in some cases. There arteriosclerosis, accommodation and arcus senilis has been no indication that these findings have of the eyes, greyness of hair, degree of baldne=, impaired the general health or response to disease etc.). No detectable radiation-induced aqinq ef- in the exposed people. fects have been noted. Aging scores evaluated at 6 46

was complicated by physical and psychic trauma and by malnutrition factors not operative in the case of the Marshallese children. The 175-rad gamma dose would seem to be too smail to cause any direct el%xt on bone growth, and the esti- mated dose to the bones tim internally absorbd Effects on fertility were not apparent as judged isotopes probably can also be disregarded since by comparison of birth rates for the exposed and this source contributed only about 3 to 4 rads over unexposed populations. During the first 4 years a 1O-year period. Bone growth studies in weatding afier exposure an increase in miscarriages and rats given sublethal exposures have shown an in- stillbmhs was noted in the exposed women, 41% direct eifect on subsequent growth of shielded legs, of the birth (13 in 32 births) in this gYoup termi- but this appears to be based largely on a radiation- nating in nonviable ofipring compared with 2 19?0 induced lowered fd consumption. ~5 It is of inter- (8 in 38 births) in the unexposed women. Since est that 25 of31 exposed children were noted to that time, the incidence has been about the same 10SCseveral pounds of weight during the first 6 to 8 in the two groups. One cannot be certain that this weeks following exposure. However, the influence ei%ct is actuallv due to radiation exposure because of change in environment in producing this effect of the smail number of women involved cannot be ruled out. No specific genetic studies have been carried out, but differences in incidenca of abnormalitia DMLOPMENT OF ?HYROID NOOULES in children of exposed compared with those of un- expcucd women have not been observed. The gen- Thyroid nodules were removed from 3 teen-age erally negative results of large-scale genetic studies exposed girls after the 10-year survey. Most pa- on the ot%pring of expcacd Japarmsd indicated that thologists consulted did not feel that radiation detaikdstltdiucm the Mmbaksewmlkinotbe hlitful. could be implicated as the etiologic agent on Ae basis of the pathological tindings alone, though GROWWIAND DEVELOPMENTSTUDIES some considered the lirtdings typicai of the lesions seen in children treated medkally with radioactive Comparison of exposed with unexposed children iodine. However, the evidence is strong that the of the same ages indicated slight retardation effects thyroid nodules in the Marshallese girls were in- in the exposed males. The boys exposed at ages 1 duced by radiation. Correlation of the thyroid to 5 showed retardation of statural growth as weil nodules with radiation exposure was substantiated as bone age. This was most marked in those ex- by statistical analysis which showed the difference posed at 15 to 18 months of age. The average in thyroid nodule incidence between the exposed skeletal maturation in the exposed boys was about and the unexposed chilk to be significant at the 7 months behind that of their unexposed peers. 1~ leveI. * Moreover, She line et al.” and Lindsav Though weight gain also appeared slightly re- et al.” have reported the development of thvrold tarded in this group, it was not statistically sigrtifi- nodules 5 to 11 years after treatment of children cant. The exposed girls showed no significant dif- with radioiodine for thyrotoxicosis. Dr. Lindsay ferences compared with unexposed giris. reported that the sections of the glands removed The slight retardation of growth in the male from the Marshallese girls were similar co the children who were expod when <5 years of age glands of children who had been given I ‘3’ * compared with uncxpo=d m~= of the =me therapy. On the basis of a calculated dose ofs 150 age suggests that radiation may he a causal factor radsL to the adult thyroids from isotopes of iodine, although poaaibk mechanisms are not clear. The it was estimated that the smaller thyroid glands of dose to bona from internally absorbed isotopes is the girls exposed at 3 to 4 years of age received a believed to have been too small to have affected total dose of the order of 1000 rads” * f probable bone growth. Adveme efkcts on growth and devel- opment of Japanese children exposed to the ‘Mr. Keith Thompon of Brookhaven,NacionaiLaboratom carried out die ~ tat. atomic bomb have been reported by Greulich.zz ..~r, R~p~ J== ~nd h, John Gofman. LawrenceRadia- Reynolds,” ~d Nehemi~.’~ However, the eval- Wn Laboratory,Livermore.California,re-examined[he ear[v uation of such effects in these Japanese children data and recalculatedthe thyroiddoses. range 700 to 1400 rack). The fact that a part of the firmation of the diagnosis. Atomic Bomb Casualty total dose to the thyroid (175 rack) was due to Commission studies have conclusively demon- whole-body gamma exposure (including the pi- strated an increased incidence of leukemia in Jap tuitary gland) may be of some significance. anew exposed to the atom bomb radiation. ‘S-JO% The fact th~t all three ,Marshallese developing increased incidence has akw been noted in patients the thyroid nodules were @la is in accord with the who had received radiation therapy for ankylosing experience of othem that thyroid neoplasia and spondylitis.” There are many reports of the late goiters predominate in females. In the report by development of neoplasia, particularly cancer of She line et aI. ” referred to above, 8 cases among the thyroid gland, following radiation exposure of 256 patients treated with 1’3’ developed thyroid infants and children. 32’36 Increased instances of nodules. All 8 cases were females: the ages at the cancer of the thyroid gland and adenomata have time of treatment in 6 were <18 (4 aged <10 and been reported in the Japanese heavily exposed to 2 between 20 and 30). In the ,Marshallese girls, the ionizing radiation from the atomic bombs. ~~-]g stress of puberty may have been a factor in the de- The Marshallese will be carefully observed for velopment of the nodules. such a possibility in future surveys. The question NOTE: During the 1Ith-vear sutwey now in pro- of increased incidence of malignancy in the ir- gress (March 1965) 3 new cases of thyroid nodules radiated LMarshallese must be left open for the in the exposed group have been detected. TWO present. were in boys 12 and 17 years of age and one in an adult woman 41 years of age. The nodules ap- “BETA BURNS” peared grossiy similar to those described in the teen-age giris in this report, and these cases will During the past several years, increased nurn-. receive study and treatment. hers of pigmented nevus-like lesions have been noted in previously irradiated areas of the skin, but these have appeared to be quite benign. MAUGNANCY Neither chronic radiation dermatitis nor cancers of the skin have been noted. Two older women who had been exposed died with a diagnosis of cancer, one at 67 years of age of ovarian malignancy at 5 years post exposure INTERNALLY ABSOR6ED ISOTOPES and the other at 60 years of age of probable cancer of the cervix at 8 years pm exposure. The diagnosis RadioChemical urine analyses and whole-body in the latter case was not confirmed bv autopsy or gamma spectrometric analvses revealed that the biopsy. One unexposed older woman died potmiblv level of body burdens of radioisotopes in the ex- of cancer of the cervix. but the diagnosis was not posed Rongelapew fell rapidly, so that bv ? and 3 confirmed. No other cases of malignancy have yearspostexposurethe levels were far below the been noted in the unexposed population. stated maximum permissible level.’5 The return No cases of leukemia have been detected in of the Rongelapese to their home isiand was as- either the exposed or unexposed Rongelapese. Pe- sociated with a rise in their body burdens of Cs’”, ripheral blood smears were studied closely for leu- Zn”, and Sr’”. By 1961, the whole-body content kemic cells, inciuding examinations for alkaline ofcs1J7 had apparently reached an equiii brium phosphatase and basoph.il counts. with the environment at a value of about 14.7 The three cases of thyroid nodules plus the two m~C/kg body weight or about 300 times the mean earlier cases of cancer in eider exposed women of the medical team measured at the same time. raise the question whether an increased frquency Zn’”, which had risen to about 9.9 mpC in 1959. of cancer may be expected in future years. How- fell by 1961 to 1.5 mpC/ kg body weight, or about ever, in evaluating the role of radiation, it must be 100 times that measured in members of the medi- kept in mind that one case of cancer in the ex- cal team. The levels of Sr*O in 1962 and 1963 hov- posed group occurred at 5 years after exposure - ered around the 12.O-mpC level in adults and too soon, it is believed, to be related to radiation about 22 myC in children, about 5 and 10% of exposure - and in the second case it was notpos- the maximum permissible level (for members of sible to obtain autopsy or biopsy material for con- the population at large). It thus appears that tmdv 48 burdens of SrgOhave reached equilibrium with the individuals, too numerous to name, for valuable environmental Sr80. Little or none of the prtient assistance. body burden of the exposed group can be consid- Many officials of the Atomic Energy Commis- ered residual from their initial exposure, since sion, particularly Dr. Charles L. Dunham, Dr. little diilkrence has been noted between the body H.D. Bruner, and many of their staff of the Divi- burdens in exposed and unexposed population sion of Biology and Medicine, and Mr. W.H. living on Rongelap Island. The possible relation Brummett, Jr. and Mr. G.P, SteRy of the San of internal absorption of radioiodines initially in Francisco Operations Office were most helpful in the fallout to the recent development of thyroid the coordination of arrangements with various nodules has been referred to above. lNo other ef- governmental agencies and in supporting these f~ts of such exposure have been detected. surveys in every possible way. We are grateful to the officials of the Depart- OTN= EXAMINATIONS ment of the Interior, particularly to Mrs. Ruth Van Cleve and the officials of the Trust TerritoW Ophthalmological examinations showed no of the Pacific Islands, inciudit-q the High Commiss- clear-cut evidence of radiation-induced changes ioner, .Mr. M.W. Goding; the Director of Medical in the eyes. Slit-lamp studies revealed no increase Services,Dr. J.W. Sampson; the District Admin- in incidence of lens opacities which might be attrib- istrator for the iMarshall Islands, Mr. Peter uted to radiation. Cytogenetic studies of the chro- Coleman; the Director of the Marshall Islands mosomes of leukocytes and peripheral blood cui- .Memorial Hospital, Dr. John Iaman, and mem- tures obtained in 1964 are in progress and will be bers of his staff; and the Representative of the reported at a later date. Anthropometric studies High Commissioner at Kwajalein, Mr. K. ?vlc- revealed that young adult Rongelap males were Kay. Mr. Don Davis and his crew of the Trust superior in muscular development compared with Territory Ship Ran .4ntm and Mr. L. Roberts and many populations. This was not true, however, for the crew of the Rope were most helpful. the young adult females. Blood volume and red As in the past, the Department of Defense, par- celi- mass determinations using tritiated water and ticularly the Department of the Navy, contributed Cr” revealed values in the Marshallese which most vitally to the mission. The Pacific Missile were considerably lower than found in American Range Facility at Kwajalein was of great assist- Caucasians. However, there is some indication ance in furnishing necessary airlifis and materials that Americans living in the Islands for more than to be used on the sumey. Dm. G. Temple, C. Cun- one year may also have slightly lower values. This nington, and Y.C. Smith at the Kwajaiein Hospi- finding will be further investigated on future sur- tal were extremely helpfid. veys. Protein bound iodine studies during the past Drs. L. Donaldson and E. Held at the Univer- two years confirmed the previous findings of levels sity of Washington have aided in coordination of higher in the Marshallese than generaily found their studies with these. elsewhere. No explanation is apparent. Folic acid We are grateful to Dr. K. Tsuhamoto. Director levels were found to be somewhat low in the of the Japanese Nationaf Institute of Radiological Rongelap population and probably reflected low Sciences, and to Dr. Dunham for arranging the dietary folic acid. serum studies for the Ag system visit of the senior author to Japan to observe the reveal that the Rongelapcsc compared with other annual examinations of the irradiated Japanese worldpopulationshavea highfrequencyofC.deB. fishermen and for having Dr. T. Kumatori visit antiserum reactors and a low frequency of New Rongclap for the 10-year survey. York antiserum reactors. At Brookhaven National Laboratory, contribu- tions were made by many individuals in many de- partments including Medical, Instrumentation Acknowledgments and Health Physics, Photography and Graphic Arts, the Shipping Section, and others. We are The cooperation of many agencies and persons grateful to the following people for their support was necessary to carry out these surveys success- and advice: Dr. Maurice Goldhaber, Direc~or: fi.dly. The authors are deepiy grateful to many Dr. J.B.H. Kupcr, Chairman of the Instrumenta- tion and Health Physics Department; Dr. V. P. 13. &f OOtSE, F., The Body ceil ,Uass and Its Supportm~ En- Bond, Chairman of the L~CdiC~ Department, and vzronmcnt, Saundem, Philadelphi& 1963. 14. BLUMBZaC othem in this department inciudirtg Drs. D.D. Van ‘ S., BCENANLE, A.D., AND ALLISON, .\. C., A hu~;.~n li~prowin polymorphism, f. Cfm. SIvke, E.P. Cronkite, J,S. Robertson, S. Cohn, [rwest.41. 1936( 1962). L.K. Dahl, H.A. Johnson, H. Cctttier, and iMr, A. 15, ALLSSON,A.C. AND BLUMEERG, B. S., An isoprecipita- Fmn and .Mr. W.J. Walsh. tion reaction distinguishing human serum-protein We wish also to thank Miss B.R. Brezisky for ~, Lutwt 1861-1,634. her secretarial asistance and Mrs. ,M. Dienes for 16. BLUMBttRO, B.S., DMY, S., AND ROFCINSON,J. C., ,ti& gwsspolymorphism of a low density beta-lipoprotein. editorial help. Aiiotypy in human serum, Nahsre194, 656( 1962). 17. BLUMBEWZ B. S., [so-antihociks in humans against inherited serum low density beta- lipoproteins. The Ag system, Ares..V. Z Acad Set. 103, 1052 ( 1963). References 18. BLUMBERC, B.S. AND RIDDELL, ~. M., Inherited antl- genic differences in human serum beta-lipoproteins. .Asecond an~ J Clin.fnoest.42.867 ( 1963). 1. CnoNxrcst, E.P. ETAL.. The Effects of Ionc.crn#Radtitzon I9. Enomnnsentai Contammatcon, Annex D, R@ort ~“ the on Human Btmsy A Report on (he .Uarshallese and.4 merc- Cnzted ,Vattons Scwntzjc Comm$ttee on the Efects o/- mns Accidentally E.rposed to RadIatton From Fallout and a .4tomcc Radcistwn, General Assembly Official Records, Dtwusston ~“Radiahon Inwry m the Human Beznq, U.S. Suppiemem No. 17 (At 3838), 1958. Government Prutting Ofice, Washington, D. C., ?0. CONARD, R..%, .kt attempt to quantifv some clinical 1956. criteria of aging, J. Gronto/. 15, 358-65 ( 1960). ?-. BONCI,V. P., CONARD,R..4., ROBERTSON, J. S., AND 21. ?JEEL, J.V. ANDSCHULL, W. J., Editon, The Efect oj- W EDEN, E..+. JIS.,,Utdzcaf Examsnatton of Ronqe[ap Pm- tht AtormcBombson Pregnang ?ermmatzonm Hiroshuna pie Six .Uonths After Exposure to Fallout, WT-937, Op and .Vaqzsaki, Publ. .Vo. 461, .Natl. .~cad. Sci., .Naci.” eration Cawle Addendum Repor~ 4.1A, April 1955. Res. Council, Washington, D.C., 1956. 3. CRONRSTE, E.P., DUNHAM, C.L., GRIFFtN, D., .Mc- 22. GREULICH, WW., The physical growth and develop PHERSON, S. D., AND WOODWARO, K.T., Tweive-.+[onth ment of children who stuwived the atomic bombing of Postcxposure Surtqy on .Uarshalltse Exposed to Fallout Hiroshima and Nagasaki, J Pcdiat. 43, 121 ( 1953). RadcuI!@, BNL 384 (T-71), August 1955. 23. REYXOLDS, E.L., Growth and Development?< Htroshtma 4. CONARD,R.A., HUCGINS, C. E., CANNON,B., Lowst-EY. Children Exposed to the A tomtcBomb. Three rear Study .~., AND RICHARDS, J. B., Medicai suswey of Manhail- ( /95/-/953), Atomic Bomb Casuaity Commmion, ese two years after exposure to fallout radiation, Tech. Rept. 20-59, p. 157, 1954. J..4-.U4.4.164, 1192-7( 1957). 24. NEHJZMIAS, J. V., .Multivariate anaivsis and the IBM 5. COXARD.R..%, MEYER. L..M., RALL, J. E., LOWREY. 704 computer applied to A.B.C.C. data on growth of A.. BACH, S,.4., CANNON, B., C.UtTSR, E., EICHER,M., suwiving Hiroshima children, Heaith Ph.Y~. 8. 165 ANDHECHTER,H., March 1957 .Utdwai Surcqyof Ron- (1962). ~clap and L_ttrzk People Three YearsAjlcr Exposureto Ra- 25. CONARD, R..4., Indirect effect of x-irradiation on dhactm Faf&uc. BNL501 (T-119), June 1958. bone growth in rats, .-inn. .V. Y. .Icad. SCI. 114. 335 6. CONMUL R..4. n AL.,,Ucdicai .huq @Ron@zp Peo#s, ( 1964). .Uarch 1958, Four rears Aficr Exposureto Fallout, BNL 26. SHZLINE. G.E., Thyroid noduics occurr]ng late after 534 (T- 135), May 1959. treatment of thyrotoxicmis with radiomchne, J, Clus. 7. CONAKD,R.A. ETAL.,.UedicafSurvq of Rongclap Pcop& Enabcnetd. .Uetab. 22, 8-18( 1962). Ftoe and Six rtar~ A+ Exposurt to F’alkwt, BNL 609 (T- 27. LINDSAY, S. AND CHAIKOFF, I.L., The effects of ir- 179), September 1960. radiation on the thyroid giand with parucular refer- 8. CONARD,R.A. ETAL.,MedicalSuroq of RongeiapPeople ence to the induction of thyroid neopiawas: A review, scum Yearsi4&r Expaswe10Fal@ BNL 727 (T-260), CanarRes 24, 1099-1107 ( 1962). May 1%2. 28 MOLONEY,W.C. AND LANGE, RD., Leukemia m 9. CONAXSAR.A. ET AL., .Ucdical Stutq of Rongdap Ptopk atomic bomb survivon. 11. Observations In early Eight Years A&r Expomreto Faltbut, BNL 780 (T-296), phases of kt.skernia, BLmd 9, 663-85 ~1954). January 1963. 29. H~YSS~L, R., BRILL .& B., AND WOODISUSLY, L. A., 10. SUSSMASS,L..N., .MEYER, L.LM.,AND CONAXD, R..+ Leukemia in Hiroshima atomic bomb survivors. Blood groupings us Marshailsxe, Scwncc 129, 644-5 Bfood 15, 313 (1960). (,1959). 30 WALD, N., Leukemia in Hiroshima Citv atomic 11. GOLDMAN, M. AND CARVER, R.K., An intestinal para- bomb SUMVOW Scrersce127, 699-700 11958). site survey on Rongelap Atoll in the ,Marshall Is- 31 COURT-BROWN, W.M. AND DALL, R., Leukemta and lands, Am. J Trop. .Ucd ffYg.8,417-23 ( 1959). Aplasttc .4nemta ut Patients [rradtated jm .4 nkvfosq 12. SUTOW,W.W., CONARD, R.~., AND GaIFFITH, K..M., Spondyhs. London, H.M. Stationery Office (Med. Growth status of children exposed to fallout tadiation Res. Councii, Speciai Rept. Series No. 2951, 135 p., on Marshall Islands, .+’ldtitrrcs, in press. 1957. 50

32. DsmY, B. J. JR. ANDFITZCmLD, P. J., Thyroid cam 36. WAXaZN, S., ALWZOUW M., AND COLCOCX, B. P., ccr in childhood and adolescence, a report on 28 Carcinoma of the thyroid inchildhood and adoics- ~ Cancer3, 1018 (195o). cence, CUncsr6, 1139 ( 1953). 33. C- D.E., .%sociation of irradiation with cancer 37. SOCOLOW,E. L., Thyroid carcinoma in man after of the thyroid in children and adolescents, J.A ..44A. exposure to ionizing radiation, .Vrw Engi. J .i4cd. 159, 1007 (1955). 266,406 (1963). 34. SIMPSON, C. L., HItMPSILMANN, C. H., AND FULLER, 38. ZELDIN, L. J., JADLON, S., AND ISHIDA, M., Current L.M., Ncoplaaia in children treated with x.rap in in- status of ABCC- NIH studies of carcino.genesis m fq fm thytnic enlargement, Ra&io&gY64,640 ( 1955). Hiroshima and Nagasaki, Awt. N. ~. Acad. .S.,. 114, 35. ROONEY, D. R. AND POWELL, R. W., Carcinoma of 225-50 ( 1964). the thyroid in children after x-ray therapy in early 39. HOLLINGSWORTH, D. H., Thyroid disease: A study &Idhood, J.AMA. 169,1 (1959). in Hirmhima, Japan, Mcdicane42, 47-71 ( 1963). APPEWDIX1

RongelapGroup and Control Mean Blood Counts at Various Times After fixpos~lre ——— — .— ..-. — —.. — .- . . .-— -—.—. .—— WBC Neutrophils Lyisphocytes Platelets Heisatocrit, RDC (X10-3) (Xlo-% (xlo-~) (xlO-’) s (X10-6) —. . -— —. .-. . .-— .— .----.- .— -..._—.—— ..— _ -— Male Male Female Total Male Male Female Male Male Female Postexposure day -=5 >5 <10 >10 ●ll ages group <1s >1S all ●ges <15 >15 all ages

9.0 8.2 b.4 4.7 l.u 2.2 ------..-. ------; b.g 6.2 ---- .-. ------..------. ..------10 6.6 7.1 3.5 4.5 2.6 2.1 a.2 22.7 24.9 24.8 ------5.9 6.3 3.5 3.9 2.1 1.7 ------. ------E 6.5 3.2 h.1 2.4 1.9 W.1 21.3 21.7 22.5 ------18 ::; 7.2 3.4 4.7 2.4 2.1 21.8 19.1 21.8 21.0 ------22 7.0 7.4 4.3 5.0 2.6 2.1 16.814.6 15.2 15.3 37.5 43.9 39.0 ------26 5.7 6.1 3.o 3.9 2.3 1.8 13.2 12.9 10.9 11.9 36.3 41.6 37.5 ------30 7.8 4.0 5.3 3.2 2.1 14.1 12.3 11.8 12.3 37.9 42.2 37.1 ------33 i:: 6.2 3.1 3.8 3.2 2.0 17.916.6 15.1 16.0 37.4 42.2 36.8 ------5.7 5.5 3.0 3.3 2.6 2.0 25.5 22.0 22.4 22.8 37.8 42.4 37.4 ------:; 5.2 5.2 2.0 2.6 2.9 2.3 S.8 20.9 23.2 23.2 37.3 41.8 37.6 ------47 5.8 2.6 3.3 3.1 2.4 24.620.6 23.9 23.1 3$).0 43.4 N. 3 ------51 2:; 5.6 2.6 3.5 3.4 2.1 22.1 17.5 21.2 20.3 ------7.0 6.0 3.5 3.5 3.7 2.4 ------g 7.7 6.0 3.9 3.6 3.7 2.3 23.1 18.2 20.2 20.1 ------... ------70 7.6 6.5 3.8 4.0 3.3 2.2 . ..------74 ------.. . . . 26.221.7 24.7 24.1 ------6-MO survey 8.5 6.6 h.6 4.2 3.6 2.2 24.420.3 23.2 22.6 38.0 41.7 38.2 .-.. ------l-yr survey 10.1 8.1 4.7 4.8 4.6 2.8 $.: ;;.: 27.6 24.9 37.5 41.1 36.9 ------2-yr survey 1:.: 8.6 5.9 4.8 4.7 3.1 25.5 24.7 *.7 41.2 38.1 ------>yr survey ;.; :.; :.; 3.7 2.7 32:022:1 28.1 ---- 35.6 33.7 35.4 ------4-yr survey 8:9 4.6 3.6 32.5 i?’-l.l ---- 35.6 41.0 35.8 ------5-yr survey 13.5 915 619 418 6.0 4.0 32.324.4 ;:: . . . . ------4.45 4.71 4.21 6-yr survey ---- 6.5 .-. 3.5 --- 2.7 ------7-yr survey ---- 7.4 ;:: ;.g --- ;.: ---- 24.6; 27.3 ---- 37.6 41.7 37.0 4.54 4.45 4.11 8-yr aurve.y ---- 6. ------32.8C ---- M. 5 43.0 39.3 4.68 4.67 4.44 $1-yrmwvey ---- z --- 3:7 --- 3:0 ---- 23.1 2:: ---- 39.1 43.7 38.4 4.29 4.@ 4.12 10-yr survey ---- ~:2 --- 3.8 --- 3.5 ii-i :.: 37.2 ---- 40.4 43.5 39.3 ------Ma.juro controls 13.2 9.7 4.8 4.8 7.4 4.1 . . 36.5 33.4 39,6 46.0 39.9 ------Rita cont. 6 MO 10.7 7.6 5.4 5.2 4.7 3.7 35.0 ------Rita cont. 1 yr ------3 .5 lp’ g:: ------... Rita cont. 2 yr 14.0 6 3.6 3.? 3 .2 29.5 42.1 39.8 ------Rong.cent. 9.8 ::; ?:: ::: l?” 2 30.0 ---- %“241.0 35.9 ------Rong.cent. lg ;;.; 8.0 4.0 3.6 $:: ;:! g:$ 34.0 ---- 35:5 42.8 35.1 ------. . 33.6 ------k%g::%: j ~ ---- l::! :;; $:: -:- ;:1 ---- 31.4 ---- 3 .2 44.4 37:: t:!% Rong.cent. ---- . ------34.5 ---- J . Rong.cent. 9 ~~ ---- ii --- 3.9 --- 3: ? ---- 32.5 ---- d :;:8 3 t% Rong,cont.10 yr ---- 9.1 --- 4.8 --- 3.5 ---- 35.4 37.9 ---- 37:4 44.1 9:: ------

b aIncludesall males>7. Includes ●ll ■ales>8. cIncludesall ●ales >$Je APPENDIX 2

AilingnaeGroup ●nd Control bfe~nBIood COUrii~ at Various Tkes After Exwsure —— —. —- WDC NeutrophilsLymphocytes Platelets Hernatocrit, RBC (X10-3) (X1O-3) (X1O-3) (XlO-’) % (X1O+ ) —— .— —.—--- — —.—— —- .—.——- .-----—— —.—.- ——— — Male Male Female Total Male Male Fenale Male Male Fe-ale Postexposureday <5 >5 <5 >5 45 >5 <10 *10 ●ll ●gea group <15 >15 ●ll ●ges <15 >1S ●ll ●ges —— .—.. — ..-.-— —-- —.-

3 ------7 ------36 22.5 22.6 20.9 21.5 -.. . ------12 .-. . ------. ..------. . . . 15 7.0 2.3 4.5 4.2 2.2 29.0 20.2 24.6 ------18 ti.5 24.9 ------2 .5 3 .5 . -.. . ------i% !!!$i$! ;3!:! d .0 ::8 d 3!8 ------.6 L .5 16.2 3$; :7 ------. 2?.0 ------.. . J t! i?!j y R 26.5 3 :0 :j ------!:9 6.5 2. 2$.0 2 .0 ------.--- 7.3 6.7 3. ! 3:8 3.“t ::; 27.0 ---- .2 ------! ------8.4 .8 3.6 4.0 2.2 32.0 18. 2 .9 U* ------. ..- ..-. N 4.6 $:3 ~.6 3.5 3.2 2.5 37.0 19. i 2?.2 6-mo survey 7.7 6.5 4.8 3.9 2.7 2.2 25.2 19.2 23.$) 22.-/ 37.5 40.1 37.3 ------l-yr survey 11.1 7.8 4.2 4.7 6.5 5.6 38.7 21.4 26.3 33.0 44.6 36.2 ------. . . . 2-yr survey 11.0 9.1 4.9 5.1 4.8 3.2 51.2 17.4 &.4 2; 35.7 44.4 37.5 ------>yr survey 12.1 7.o 5.5 3.9 5.6 2.6 40.8 31.2 ---- 37.5 40.6 35.6 ------4-yr Survey 11.5 7.5 2.8 3.7 7.0 3.3 33.2 %: 33.6 ---- 36.1 43.1 35.7 ------5-yT survey ---- 9.7 --- 5.1 --- 3.7 40.9 26.3 26.8 ------4.46 5.15 4.31 6-yr survey ---- 7.3 --- :: ::: j.: ------7-yr sm.rvey ? ---- 25.6a 28.1 ---- 36.0 44.2 37.0 4.19 &yr ourvey ---- ~:z z~l 3.4 --- 2;6 ---- 33.4b 32.7 ---- 37.0 42.5 37.8 ::$ 4.35 9-yr 8uzwey ---- 4.0 --- 2.4 ---- 23.5C 23.6 ---- 36.0 44.0 3.77 4.10 l~yr survey ---- ;:; = 3.6 --- 3.1 ---- 32.4 41.5 ---- :;.: 43.0 % ------NsKluro controls 13.2 9.7 4.8 4.8 7.4 4.1 41.2 25.8 36.5 33.4 . 46.0 39.9 ------Rlta cont. 6 mo 10.7 7.6 5.4 5.2 4.7 3.7 35.0 . ------Rlta cont. 1 yr ------...... --- 37.5 ip % :2 ------Rlta cont. 2 yr 14.0 8.9 7.0 4.4 5.6 3.6 35.5 3 :2 29.5 $.~ 42.1 39.8 ------Rong. cont. 9.8 6.9 4.0 3.4 ---- 41.0 ------Rong. cont. Zg 11.2 8.o 4.0 3.6 6.4“! ;;? %:$ ---- 35:5 42.8 %: z ------Rong. cont. 5 yr 13.710.1 6.2 5.2 6.2 4.1 35.8 28.0 ------4.60 4.80 4.40 Rong. cont. 7 yr ---- 7.8 --- 4.2 --- 3.1 ------44.4 37.0 4.52 4.68 4.12 Rong. cont. 8 yr ---- 7. --- ;.; --- q ------.0 4.60 4.4 Rong. cont. 9yr ---- 7. ? --- . --- 3. ------8 4.33 t:% 4.1 J Rong. cent.10yr ---- 9.1 --- 4.8 --- 3.5 ---- 35.4 37.9 ---- 37.4 38:; ------. . . .

a D Includes all males >7. lncludea all males>8. ‘Includes●ll malea>9. APPBNDIX 3

Utirik Group Mean Blood Counts at VariousTimes After Bxpo$ure —— ~.—. .—.— .—. —. ...—_._.. .._ _ -_ --- — --—— ______WBC NeutrophilsLymphocytes Platelets Hematocrit, RBC (X10-3) (X10-3) (X10-3) (X10-4) 8 (X1O-*) ------—— --. —.- . . . — —— - --— —. . . --- . —---- ..- . - —-—______— ---- - _ _ Male Male Female Male Male Female Male Nale Female Postexposureday <5 >5 <5 >S 15 all ages <15 >15 all ages .— — — -.— —- - — —. -.— —— ——_ ___ _ - _ ----

4 9.4 8.2 4.7 4.2 4.9 3.2

14 10.0 8.6 4.1 3.2 5.1 2.9

19 38.9 *.1 35.6

29 10.1 9.7 4.9 .5.8 4.8 3.2 34.5 25.6 31.7 39.9 45.1 39.4

3-yr survey 9.8 6.9 4.o 3.4 4.7 2.9 32.6 26.9 30.0 35.6 41.0 35.9 4.12 9-yr survey --- 7.0 --- 3.9 --- 3.0 ---- 36.5* 3&9 37.9 42.4 37.7 4.42 4.39

—● .—. Includes all males>9. APPENDIX 4

Individual Heaetologicsl Findings~ 1963

Subject Plate. WC Neut . L~Phe bionoe Eosin. Baso. Hctc, RBC Hgb. , se No. (x.lo-3) (xlo-3) (xlo-3) (xlo-3) (X10-3) (X10-3) (X104) % we-4) g prot

Roage18p Bposed MalesP Age 9-15

2 224 8.03 2.41 0.16 0.24 1.60 402 13.2 8. 3 285 ::% 0.48 1.16 1** 370 13.6 8. 440 &; 6.07 ::Z 0.95 0.36 2*9 * 13.6 7. 1; m 6.03 2.89 2. bl o*30 0.42 0.0 13.6 7. 23 344 2. n :.2 ::: 1*OO 0.0 g =.8 7. 32 ;:: 3.43 0.66 O*7O 413 14.0 6. 6.97 2.72 3:69 0.28 0928 0.0 459 LJ+.O 7. $* g U.90 3.lJ5 0.95 2*9 0.0 422 14.8 ;.: 85* 257 7.29 ::Z 3.lb3 0.66 0.58 0.0 456 14.4 287 8.47 3.92 3.25 0.44 0.79 0.74 39.1 13.8 7 266- *.18 il.~ ?0.59 ?2.0 ● (3.5 20

Ailingnae Exposed M81es~ Age %LS

6 194 6.64 2.79 3.19 ::$ 0.60 0.0 377 12.4 7 m 1* 6.64 2.79 3.19 0.60 0.0 $.0 377 u. 4 7

Rongelap )Zxpesed,%mles. Age 9-1S

M7 14.70 12.20 2.06 0.15 0.29 0.0 k3 15.2 8 m 7.15 2.72 0.21 1.14 0.70 42 14.8 355 8.25 2* Sq G 0.08 0.91 0.80 13.2 :: g 8. u 3.66 4.24 0.25 0.17 0.0 14.8 8 7.92 3.64 3.41 0.32 0.48 0.80 12.4 7 7.05 2.61 3.81 0.21 o*35 0.70 39 13.6 7 z: 7.27 3.42 0.44 0. (Y? 0.70 39 14.0 8 247 7.33 ::: 2.35 0.29 0.44 0.0 39 1s,6 7 m 8.50 4.42 3.3 0.24 0.48 0. b6 39.5 13.9 8 Y@ ● 2.49 ? 3.09 ?o.& ~ 2.0 ~ 0.9 ?

A41incase m sed Peules~ Age 9-15

203 7.05 3.33 3.03 0.21 0.42 0.0 40 415 14.4 4L48 7.25 3.99 2.90 0.22 0.15 0.0 42 456 15.6

~225 7.15 3.69 2.97 0.= 0.26 0 41.0 435 15.0

*Expo8ed in utero. ●*Sttiard deviation. 35

Subject Plate. WC Neut. L~h. Mono. Eosin. B-. Hct*s RBC High,, serum No. (X10-3) (xlo-3) (xlo-3) (xlo-3) (X10-3) (xlo-3) (xlo-2) % (do-’) g protein, g — Roiigehp Expoeed M81es, Age wM-40

9 128 7.25 3.26 3.77 0.15 0.07 0.0 ti.o 10 3m 5*9L 2.84 2.54 O*L8 0.30 0.60 1P R 20 M2 4.91 2.41 2.06 0.25 ~.2J 0.0 17.9 8.0 27 U3 7.82 3.36 k.30 0.0 0.0 164 36 231 2.35 2.05 0.15 0:45 0.0 15.2 7.5 ~: $ 2.46 0.13 0.52 0.0 L6.o 7.4 z 231 ::$ 3.43 0.16 O.a 0.0 14.8 7.1 lb? 232 5:lb5 2.83 2.13 0.L6 :.$ 0.0 L6.9 7.7 73 183 5.17 2.95 1.76 0.26 0.50 17.4 7.1 76 138 9.73 ;*7J 3.99 0.29 0:% 1.00 15.2 7.6 77 230 6.71 . 2.55 O.* 0.20 0.70 16.4 8.0 - 198 6.58 3.z7 2.& 0.19 0.28 0.25 16.1 7.6 % *1.49 ●0.74 *O.* ?1.3 ~o.3

Roogel 8P Exposed Fe-lest Age ZM_40

3.2 625 7.& 4.76 2.65 0.39 0.0 0.0 14 250 7.70 4.47 2.85 0.23 0.15 0.0 4:: ::; 15 345 7.66 :.% 3.14 0.38 0.15 0.0 13.2 7.7 18 208 4.88 1.81 0.20 0.10 0.0 13.2 7.3 22 208 7.14 4:21 1.93 :.g 0.93 0.0 14.4 7.7 24 260 2.25 2.59 0.52 0.60 14.8 7.8 133 ;: E 4.37 2.15 0:22 0.67 0.0 u.8 7.5 z 322 6.39 3.20 2.75 0.13 0.26 0.60 L2.4 7.8 61 373 8.87 3.64 ;*7J 0.0 :.&& 0.90 14.4 8.5 64 193 8.87 5*IU 0.44 0.0 10.9 7.1 66 219 8.39 3.69 3:78 0.59 0:34 0.0 13.6 7.3 n 9.26 5.93 :.: 0.37 0.65 0.0 15.2 8.0 W $; 14.30 ?.@ 0.14 2.43 1.40 14.4 8.8 75 288 7.97 4.% 2:39 0.32 o.~ 0.0 14.4 8.5 - 0.25 13.2 7.8 :1.8 ~o. 5

meal Fe=sles, Age >1S-40

51 241 6.55 ;.OJ 2.29 0.13 0.0 1.30 15.2 291 7*53 3.77 0.15 0.15 0.0 14.4 ;:; ?2 2b3 0.82 7:23 1.06 0.26 0.26 0.0 9.4 7.4 81 m 8.94 7.o6 1.07 o.k5 0.36 O*O 12.4 7.3 Ineallm 7.96 5.45 2.05 0.25 0.19 0.32 3.2.9 7.7 56

Subject Plate. WC Neut. Lymph. Mono. Eosin. Base. Hct. > RBc Hgb.? Serum NO. (xlo-3) (xlo-3) (x.lo-3) (ldo-3) (xlo-3) (xlo-3) (xlo-2) % (xlO”’) g protein,g

- Rongelap ~posed Usles, Age> 40

4 245 8.o2 2.73 O.a 0.0 0.0 47 w? 16.4 8.4 7 113 x 0.0 0.29 0.60 14.0 7.8 u 103 ;:$ ::C 2.78 0.05 0. U O*O ; ?% 15.2 7.1 208 2.57 2.41 0.16 o.21 0.0 291 10.9 7.0 z ::% 2.m 2.04 0.29 0.43 0.0 z 420 14.4 79 % 3*n 2.87 0.21 0.42 o*o 48 464 16*9 8.1 80 306 $: 3.60 3.68 0.08 0.64 0.0 42 408 14.4 7.3 82 307. 3.52 2.08 0.31 0. N 0.0 39 462 14.0 7.7

=4 6.33 2.88 2.99 0.15 o.31 0.08 41.3 410 14.5 7.6 *87 *1. 24 to. 59 ?1.04 25.4 :!% ‘-o. 5 :0.4

Ailingnse Exposed Males * Age *4O

ti 203 4.78 1.96 2.53 0.0 0.29 0.0 44 543 14.4 7.4 29 356 9.10 5*55 2.46 0.55 0.36 O.le 42 Ib19 15.2 7.8 41 104 4.70 1.97 :*UJ 0.19 0.47 0.0 453 16.o 7.7 50 w 6.94 3.47 . 0.35 0.28 0.07 2 461 17.4 7.4 245 6.38 3.23 2.46 0.27 0.35 0.06 44.0 15.8 7.6

Rongelap Bxposed F-less Age >40

404 2.36 2.42 0.21 0.9 O*O 37 12.4 8.o 226 ;:: 3.34 2.40 0.25 0.32 0.0 * 13.2 8.1 286 3*76 1.82 0.11 0.0 0.0 ;; :.: 7.5 =5 6:n ;.$ 3.56 $: 0.14 0.0 6.36 3.24 0.32 0.64 K:l 7.5 R 4.66 2:14 2.(M 0:23 0.28 0.0 i!; 16. o -f. a 219 5.62 3.09 2.47 0.0 0.06 0.0 39 1s 7.9

0.21 0.09 38.1 13.3 7.8 22.5 :1.4 :0.2

AiliOiWSe Exposed Femeles,Age w40

ti 8.20 b.42 3*28 0.08 O.kl 0.0 40 402 14. b 8.3 $ 204 6.4o ;.9J 2.43 0.26 0.70 0.64 459 15.2 9.2 43 268 0.64 O.a 0.27 0.53 :; 428 13.6 8.k 45 3W 7:E 3:98 L*85 O.zl 1*W 0.0 36 %3 13.6 8.0 59 235 8.%i 3.67 3.67 0.99 0.63 0.0 37 365 =.8 7.9 - * 7.~ 3.83 2.37 0.35 0.62 0.23 38.0 403 13.9 8.k +7 ?1.60 +.57 :1.20 22.6 ? 41 21.1 :0.4 Sub ject Plate. WBC Neut. Lymph. ~t10. Eosin. Base. Hct., REC’ Hgb., Semnn No. (X10-3) (xlo-3) (X10-3) (xlo-3) (X10-3) (xlo-3) (s0-2) % (xlo-4) g protein, g

Male Children of 2Xp0 aed Parents, Age -3

88 323 10. x 1$.22 0.0 0.52 L03 35 1.2.2 & 39 9*m b.60 ;:2 0.20 1.17 0.0 14.4 ;:: 90 u. 70 5.15 3.74 0.35 2.46 0.0 $ =.8 7.2 91 % 6.09 2.% 0.19 0.9 0.95 37 ~. 4 7.5 93 310 1::% 6.00 b.14 0.44 0.33 0.0 36 u. 8 * 2.87 0.50 0.0 I.&lb 7.2 102 i:: ::$ 3*79 ::$ 0.33 0.0 :; 13.2 104 8.00 4.32 0.24 0.0 38 13.6 7.8 109 ?? 19.20 ::$ 1.2.29 0:77 1.15 O*O : 10.6 llo 283 7*93 5.00 2.62 0.32 0.0 0.0 Y.2.8 lU 574 7.65 2.91 4.13 0.30 0.30 0.0 1.2.8 1.13 423 Lo. 50 5.67 4.41 1.05 E 13.2 115 453 17.80 12.82 ::: $: 0.0 31 IL!*2 u6 490 9.31 X 5*96 0.19 O*O 37 13.6 1.18 2?2 13.60 6.53 0.95 0.68 0.0 38 U. 8 126 4i7 8.03 %69 N 0.32 0.16 0.0 31 10.0 - 374 10.60 4.49 5.15 0.39 0.% 0.19 36.5 u.6 7.3 ?95 23.49 h. 19 ?3.04 ?3.0 ?1.1 :0.4

Female Children of ~ sed Parents,Age4

8’? 352 9*79 b.41 4.64) 0. kg 0.29 0.0 37 13.2 7.9 92 2* 7*73 b.@ 2.40 0.62 0.70 0.0 37 12.4 7.8 94 485 13.80 7.45 4.69 0.69 0.97 0.0 39 14.4 414 L2. 50 7.25 4.63 0.50 0.13 0.0 37 13.2 7.3 lx 438 25.80 ;,~ 16.00 1.03 1.03 0.0 40 14.0 103 268 U.*lo k.oo 0.22 1.00 0.0 13.2 105 * u. 50 5:& 5.41 0.23 0.23 0.0 % 13.2 M 8.52 4.60 0.51 0.26 0.0 35 1.2.1 108 g 19.40 i:g 5.24 0.58 5.24 1.+ 36 458 9.08 4.99 3.54 0.36 0.09 0.91 36 W 117 3b3 8.78 4.04 3.95 0.53 0.26 0.0 10.9 Llg g 13; 70 5.62 5.89 0.69 1.51 0.0 z 1.2.1 10.30 2.37 6.59 0.72 0.62 0.0 40 L2.8 L22 419 1.2.al 2956 8.42 0.61 0.61 0.0 36 13.2 I.aJ 468 1.2.90 3.23 ;.f$ 0.13 0.90 0.0 38 u..8 125 220 9*35 3.18 O.a 0.0 0.0 36 12.8 =7 3.75 ;:5C& ‘.& 0.13 1.25 30 10.6 lx ::$ 2.35 . %75 0.32 0.0 38 14.8

12.20 4.76 6.(37 0.55 0.79 0.23 36.8 u.8 :4.29 :1.92 22.2 :3.00 :1.0 7.7 58

Subject Plate. WC Neut . LPph. UOnOc Sosin. Baso. Hct. , W Hgb. , Seru8

No ● (xlo-3) (X10-3) (xlo-3) (X10-3) (xlo-3) (xlo-3) (xlO-z) % (A04) g protein, g

COnt~l ktsles~Age 9.1S

813 254 8.24 3.46 0.49 0.49 0.82 13.2 814 252 L= ::; 5.38 0.* 0.78 1.32 ix 14.0 i: 815 228 5.69 2.22 3*Q7 0.3.3. 0.28 0.0 * 13.6 8.k &. m u.60 6.50 3.94 0.81 0.35 0.0 &l 13.2 7.5 460 lb.~ 1.6g 2.24 0.05 0.59 0.0 420 140 7.5 820 283 6.91 2.21 3.32 0.14 1.38 0.69 460 144 7.5 863 m u. 30 7.35 3.16 0.0 0.79 0.0 448 15.2 7.7 913 370 7.* 5.45 1.95 o.% 0.08 0.0 14.0 7.8 919 264 1.68 o.31 0.3’7 1.05 ;: 14.0 7.8 921 133 ;:$ ::Z 2“.92 0.32 0.56 0.81 451 13.2 7.3 931 355 U.* 5.83 3.09 0.48 2.* 1.19 420 14.4 981 258 13.6Q 6.39 5.S 0.54 1.09 0.0 429 15.6 1033 275 5.29 2.01 2.86 0. u 0.26 0.54 486 14.4 8.3 103JS 352 5.81 2.03 3*37 0.3.2 0.29 0.0 W9 14.8 8.1

w 286 8.37 4.07 3.27 0.30 0.69 0.44 433 14.1 7.8 22.90 ● :78 *1.96 ?l.U * S.7 ?0.4

Control Fe=les, Age 9-15

8u 527 1:.2 3.82 5.62 o*21 0.95 0.0 355 32.4 7.5 8L2 310 2.81 2.81 0.27 0.73 0.67 405 3.2*7 7.8 8&6 @ 7:38 2:80 4.06 o*37 0.15 0.0 462 14.0 7.6 234 9.65 3.76 0.10 0.19 0.97 3.2.1 7.1$ 891 243 13.60 i:: L08 1.22 0.0 0.0 ~ 15.6 m 8.83 3.62 2.91 0.35 1.85 O** 441 14.0 E 9= g 6.03 1.69 3.* 0.0 0.36 O*O 415 13.2 7.6 925 7.41 3.41 3*% 0.22 0.0 470 13.6 8.4 926 %3 1~.6& 7.4a 4.08 0.14 ::% 0.0 16.k 9.0 410 L? E. 8 7.7 3 420 9:43 5.66 O*O 0.0 0.94 461 16.0 7.6 955 m 8.59 3.26 ::g 0.09 o.* 0.0 14.4 8.2 959 335 7.64 3. n 3.13 0.22 0.69 0.76 g 14.4 7.9 960 250 8.92 4.28 4.37 0.0 0.27 0.0 12.4 8.0 962 $ 1.98 2.76 0.4 0.22 0.55 % u. 5 8.1 996 ;:2 4.65 4.45 0.19 0.39 0.0 367 u. 5 7.8 1035 263 7.77 3.U 3=57 0.23 0.78 0.78 453 15.2 8.5 8.82 4.Z2 3.86 O.* 0.48 0.35 424 13.7 7.9 z 22.20 :1.64 ?0.77 ?40 ?1.6 ~o.!$ 59

Sub ject Plate. WC Neut. LymP&Ia )iOnO. Eosln. Baso. Hct., MC Hgb., Seru9 No. (X1O-3) (do-% (fro-3) (X10-3) (tie-3) (X10-3) (fro-2) % (xlo-4) g protein,g

Control M81est Age >1*40

822 6.04 2.78 2.% O.la 0.L2 o*o 14.0 8.0 823 3.24 2.10 0.06 0.23 0.60 14.8 7.4 83o ;:; 5.06 1.23 0.31 1.07 0.0 16.4 831 ;. ~ 2.74 0.30 1.06 0.0 17.9 ::: 833 . ::E 2*M 0.0 O.u 0.0 16.0 834 2.24 :.$ 1.01 0.72 L5.2 ::; 836 ~:; ihx9 ● ::: 0.44 0.0 14.8 8.5 89 2.55 0.35 0.0 lag 8.3 840 6:74 3.37 M 0:40 0.0 0.0 L6.o 842 8.82 2.82 4.15 0.53 1.15 1.76 I.&l+ ::: 872 7.9 4.50 2.66 0.22 0.0 0.0 16.4 8.4 874 1:.$ 10.59 2.68 0.0 0.13 0.0 13.2 881 ● 5.78 2.24 0.35 0.26 0.0 15.6 E @ 2.35 2.97 0.23 0.17 0.0 15.2 $: 6.u 2.bl 0.65 0.0 0.93 16.0 ::: * 3.55 3.16 0.24 0.16 0.0 16.4 8.8 9s 8:67 5.2Q 2.51 0.35 o.b3 1.73 14.0 7.7 967 8.54 3.84 :.$ o. T7 0.0 17.4 m 7.20 lb.46 ::3 O.lk 0.0 16.9 $:; 1500 7*% 3.91 2.66 0:15 0.67 0.0 17.4 1501 6.16 2.83 2.90 0.31 0.06 0.60 16.b 8:0

7*77 4.07 2.96 0.28 0.40 0.30 45.7 473 16.1 8.0 21.44 ?1.86 20.90 * 4.7 :32 ?0.5 20.4

Control Fe6ales~Age >15-40

825 355 8.02 3.93 3.69 0.40 0.0 0.0 40 466 =.8 8.9 826 3!% 3.56 1.35 0.16 0.32 0.0 * 44)8 1.2.4 8.2 829 ;: g 3.* 2.89 0.07 0.29 0.0 33 355 1.2.1 8.0 832 E 6.(% 2.85 2.97 0.L2 0.12 0.0 3J L% 14.0 8.3 841 264 6.34 2.* 0.13 0.19 0.0 424 =.8 8.0 843 253 6.43 2*96 ::2 0.19 0.32 0.0 35 376 13.6 7.0 865 263 :.g 3.58 2.34 0.06 0.12 0.60 12.8 ’995 320 2.54 3.48 0.20 0.47 0.0 z $? 16.4 1; w 7:35 :*8J 0.29 0.44 0.70 42 14.8 8.7 914 % 7.88 ::$ 0.32 0.16 2.36 w 136 916 3* 4.84 2.47 1:79 0.15 0.39 0.48 2 425 13.6 ::; 9= 411 9.73 7.01 1.85 0.39 0.4 0.0 41 467 14.0 8.7 932 12 g.a 6.45 2.30 0.0 0.46 0.0 43 330 L2.1 934 3=99 2.73 0.30 0.37 0.0 37 414 =.8 ;:; 99 170 d:z 5.40 ;.:; 0.54 1.73 0.0 39 402 14.0 8.7 993 8.83 0.0 0.44 0.0 9 428 14.0 7.8 951 264 9.75 2:$ 2:44 0.59 0.39 0.0 36 396 u. 4 7.1 965 288 7.16 4.80 1.93 0.07 o*36 0.0 39 ~; 14.0 7.8 993 m 7*5I 3.ti 3.s 0.15 0.23 0.0 43 15.6 993 245 6.29 3.46 2.45 0.19 0.(% 1.26 * 419 14.8 ;:: lW1 258 9.2b 5.82 3.05 0.18 0.18 O*O 420 U*I+ 70 1043 414 9.* 6.26 2.6b 0.39 0.49 0.0 z 455 13.2 1502 265 7.88 3** 3.86 0. L6 0.08 0.0 9 451 13.6 ::; mm 7.65 ~ 4.23 2.63 0.22 0.35 0.23 9.3 421 13.6 7.9 :1.47 ?1. 34 20.78 :2.8 ?39 :1.0 ~0.6 60

Sub ject Plate. WBC Ueut. Lyxph. MOnO. Bosi.n. Basoe Hct.t W Mb. Serum

No. (X10-3) (X10-3) (xlo-3) (xlo-3) (-0-3) (xlo-3) (-04) % (xlo4) g proteinsg

– Control Males, Age >40

* 375 a. 58 4.12 3.86 0.17 0.43 0.0 46 461 16.9 a53 32e 6.84 3.15 3.21 0.14 0.34 0.0 m 13.6 ::; a55 253 6.38 3.3 2.55 :.XJ 0.32 0.64 z f5 14,0 8.0 a56 293 5.52 2.21 2.70 0.55 0.0 14.0 7.a 862 240 4.21 2.39 0:28 0.07 0.70 E 400 14.4 7.5 a73 363 1;:; 5.89 3.% 0.32 0.54 0.0 46 440 16.o 7.2 a75 196 2.73 2.17 0. Lo 0.3.0 0.52 48 483 17.4 7.4 878 232 5:65 2.49 2.77 0.34 0.06 0.0 418 14.0 880 7.66 3.75 3*29 0.38 0.23 0.0 $ 487 16.4 ::: 883 s 1.88 ;.O!J 0.29 0.06 0.0 43 406 L4.8 884 418 M 4.06 0.33 0.33 0.a3 41 406 L4.O ::; 886 8.13 4.47 3:41 0.0 0.24 0.0 W 13.2 8.8 915 2.09 1.75 0.05 0.97 0.0 2 g 14.8 7.8 911 #3 ::2 2.44 0.19 0.13 O*O a.2 260 7.32 ::: 3.44 0.15 0.73 2.20 47 456 16.4 7.8 935 w 2.15 2.46 0.41 0.10 0.0 47 @ 16.4 8.4 27 338 ;:: 4.04 2.72 0.16 0.78 0.78 3 12.8 7.9 IJ 6.88 3.23 3.23 0.14 O.a 0.69 43 L? 15.2 7.6 961 5.77 2.37 2.= 0.23 1.04 1.15 45 4n 15.6 7.2 w 198 5*18 2.49 1.76 O.a 0.67 0.52 40 376 14.0 7.5 969 417 5.58 3.07 2.32 O.11 0.56 35 376 n.a 7.1 1007 333 5.a7 2.64 2.88 O.la :: s 0.0 J@ 13.2 8.1 1041 358 6.% 2.08 3*97 0.26 O.m 0.0 g 442 14.4 a.6

~ 6.65 3.17 2.a5 0.20 0.$ 0.37 42.1 428.7 14.7 7.9 tl. 40 . ?0.99 tO .67 ?3.3 ?47 20.5 ?0. 5

control Feules, Agew40

g 234 6.43 3.60 2.70 0.06 0.0 0.64 g =.a m 7.19 3.24 2.88 0.50 0.50 0.72 t 14.4 as 241 6.49 2.53 3*37 0.32 0.19 0.65 35 3ss 1#: 7.4 a52 457 Lo.& 3.89 0.65 0.32 0.0 38 7.8 a59 410 5.88 ::$ 2.65 0.2’9 0.0 39 379 14;0 m 3k3 1.99 ;:;5 O.la 0.0 36 341 1.2.4 ::: %3 37 ;:$ 2:? 2*U 0.29 0.77 0.0 g 15.2 8.7 w 298 4.61 2*27 0.15 0.0 2.93 z 14.0 898 333 M 4.41 3.al 0.09 0.35 0.0 40 393 15.2 ::: m 260 6.3.2 3.la 2.26 0.31 0.31 0.61 40 361 14.0 928 26a 1** 3.a2 0.36 0.30 0.0 38 13.2 ::; M 3.37 2.16 o*C6 O*36 0.60 40 G 15.2 z a.26 3.72 3.88 0.41 0.25 0.0 37 13.6 !:; 941 :.g 0.36 0.3?8 0.89 9 F3 14.0 7.5 13.2 7.4 9# ● ::: ::; 0.26 0.39 0.0 39 392 3.01 2.25 0.36 :.lJ 0.0 37 12.8 7.5 957 ::g 2.90 3.30 0.13 0.0 37 :E 14.0 7.8 970 a.44 2.70 0.08 0:08 O*O 36 419 u. 8 MY@ 6.32 3.3.6 ::? 0.19 0.19 0.0 37 440 13.6 ;:; - 33.8 7.21 3.67 2.98 0.26 0.27 0.37 38.3 393 13. ? 8.0 :1.40 21.20 ?0.94 ?1. 7 229 -m. 9 ?0. 5 Subject Plate. WBC Neut. Lym~ ● MOnO● Eotin. BaeO. Hct ., RBc Hgbs s Serum No. (X10-3) (X10-3) (xlo-3) (xlo-3) (xlo-3) (xlo-3) (xlo-2) % (xlo4) g protein, g

Control Mslee, Age*9

al Lo. 30 5.46 0.41 1.34 0.0 453 13.2 7.4 802 -8.61 ::$ 3.01 0.34 0.34 0.86 UO 14.0 6.8 803 4.88 3.50 0.55 0.28 0.0 =.8 7.5 2:% 6.30 3.40 0.% 2.52 0.0 R 14.0 E u. 10 4.55 o*44 1.10 412 1.2.2 7.3 w 12.90 6.19 ::; 0.26 L ~ 0.0 455 L4.O 870 10.50 5.78 0.63 1.26 1.05 445 14.0 7.3 9@ 14.40 lo.& ?: 0.0 1.30 0.0 12. b 12.90 6.32 5.55 0.65 0.39 0.0 & 12.1 !$: 12.30 0.86 0.0 424 1.2.k 1002 19.30 ::; 2:: 0.0 i:g 1.93 462 1004 16.30 9.94 0.65 0.0 8.15 439 ::ii 8.27 2:% 4.88 O.d 0.74 0.0 Q9 :.: 1CQ9 8.14 3.26 4.23 0.24 0.41 0.0 b38 10LO 545 :.7(J 0.32 0.21 0.0 3* 13:6 1014 313 z:; ::: 0.38 1.02 0.0 444 12.4 1015 167 12:20 2.81 7.81 0.85 0.61 1.22 14.4 1017 416 9.62 4.62 4.62 0.38 0.0 0.0 :g u.8 1024 223 6.09 2.19 3.41 0.30 O.ti 1.23, 413 u.8 1027 9.15 k.a 4.76 o* 09 0.0 419 12*1 1030 E Sb. m 5.04 8.26 ::2 0.0 1.40 493 12.1 1o37 235 7.87 2.51 0.16 1*1.O 0.0 425 1038 376 9.66 2.41 ::$ 0.39 0.19 0.0 438 ?+= 1040 258 8.& 3.n 4.23 0.35 0.35 0.0 413 IL 5 1045 545 K.-lo 3.k3 8.26 0.76 0.25 0.0 439 10.6 1046 10.70 2.& 6,74 0.64 0.% 0.0 442 u. 5 1047 7.22 2.96 3.61 0.29 0.29 0.0 H u.8 1503 8.59 2.15 5.50 0.60 0.34 0.0 12.8 1504 9*53 3.81 5.15 0.s 0.23 0.0 456 13.2

me8n 375 10.91 4.40 5.29 0.40 0.79 O*9 36.9 434 L2.5 7.3 tl19 22.87 21.82 ?1.87 21.0 20.2

Control Fem81est Age~9

808 9.7k 5.06 4.09 0.29 0.29 0.0 14.0 8.5 830 lo. w 5.25 4.02 0.62 0.41 0.0 F9 14.0 866 2.02 3*55 Of% 0.49 0.0 14.4 ;:; ::: 3.61 ;: 0.34 0.* 0.0 2; 13.6 8.0 E 12.60 3.93. 0..38 0.76 0.0 u 13.2 ~ 1o.40 4:78 0.3,0 L.* 0.0 382 10.9 8.71 M 0.0 1.05 0.0 m 14.0 w 7.67 ::: O.d 0.31 0.0 u2.8 923 0.88 K! 3.29 o. lfl 0.9 0.0 3 3.2.2 7.5 &3 low 4.26 0.22 0.42 0.0 436 13.2 9*37 ::: 5.90 0.19 0.94 0.0 454 12.4 103.2 7.52 2.33 0.23 0.83 0.75 * L2.8 1020 u. 70 3.* ;:Z ::3 0.23 0.0 * 12.k 102X 15.40 5.08 ;*2J 2.62 0.0 419 U. 8 1022 7.34 1.47 0.37 0.44 0.0 393 13.6 1025 16.20 6.64 8:59 0.65 0.32 0.0 439 =.8 1026 8.L2 2.92 4.47 0.41 0.34 0.0 392 1.2.1 1028 12*50 3.75 7.75 0.63 0.38 0.0 402 3.2.1 1029 3.2.10 3.55 6.77 0.56 0.22 0.0 446 12.1 1o31 YpJ L41 f.: 0.45 O*9 0.0 456 13.2 1034 3.90 0.43 0.0 0.0 403 14.8 1044 10:70 3.32 6:21 0.75 0.43 0.0 424 u.8

333 10.15 3.83 5.31 0.36 0.64 0.03 415 13.0 7.9 :101 :2.50 $1.23 21.60 :24 :0.9 62

Subject Plate. WBC Neut. Lymph. Mono. Rosin. Baso. Hct.~ R8C Hgb.v Ser= No. (xLo-S) (Xlo-% (X10-3) (X10-3) (X10-3) (X10-3) (xlo-~) % (do-’) g protein, g — Utirik Malest Age 9-1S

2.302 9.84 5.93 0.3.0 0.30 0.0 419 1L8 7.9 2106 15.10 ?:$ 5.7b 0.45 1.36 0.0 w 14.4 2U5 13.40 4.96 0.40 0.40 2.68 455 15.2 ;:: :. 5J i:g 2.73 0.23 0.15 O*76 42s 13.6 8.0 2136 2.$m 2.72 0.19 0.37 0.0 14.4 202 7:87 3.7o ;.~ O.@ 0.24 0.79 z 15.2 ;:; 23.51 7.20 3.02 . 0.14 0.58 0.0 472 17.4 7*7 2155 7.89 3*95 0.32 0.87 0.0 lb18 17.4 7.7 ZL74 3.2.10 :.g ?: E O*36 0.8s 0.0 lb56 14.8 7.5 2179 8.30 3.32 0.08 0.25 0.0 ~ 14.0 7.0 6.M 2:44 3.23 0.24 0.18 0.0 14.8 =42 8.86 419 14.0 ;::

9.20 4.57 3*(39 0.24 0.50 0. s 442 15.0 7.6 :2.88 21.83 :1.17 223 ?1.2 ?0. 3

Utirik Fe-lest Age 9-1S

al U.& 6.84 3.60 0.35 0.70 1.3.6 418 14.0 8.2 2U3 411 9.65 7.04 1.83 0.48 0.29 471 14.0 8.2 395 8.01 3.68 3.68 0.32 0.32 ::: 424 :J.; 8.7 a;. g 13.40 7.91 4.42 :.$ 0.40 0.0 416 8.0 21&l 8.35 4.68 2.67 0.75 o.8b M 14:0 7.6 a97 2!35 6.42 2.63 3.27 0:19 0.26 0.0 L2. 1 7.3 2.80 0.38 0.76 1.645 g 14.4 2213 526 M 2:; 3.05 0.35 0.61 0.0 lb53 14.4 ;:; m ;8$ 3*72 b.19 0.19 1.U 0.93 475 16.o 7.8 3*T3 5*33 :=2 0.29 0.0 13.3 7.8 z 5:89 2.81 2.81 . 0.32 0.0 4% 1.2.4 7.6 424 5.75 2.88 0.29 0.0 450 14.0 8.0 393 15.20 9.73 ::E 0.15 ::$? 436 14.4 8.1 22% 326 7.77 4.27 2.72 o.~ 0.39 ::% 43.0 14.0 7.7 2255 413 10.40 5.10 3’.s5 0.31 1.04 1.04 433 14.4 7.8 2256 481 6.48 3.76 2.40 0.13 0.19 0.0 w 14.0

9.01 4.81 3.33 0.29 0.53 0.40 w 14.0 7.9 ~2. 04 :2.66 .@.* :S :1.0 ~o. 4 63

Subject Plate- WBC Neut. Lymph. Mono. Eosin. Base. Hct. , RBC Who, Serum No. (X10-3) (X10-3) (X10-3) (X10-3) (xlo-3) (X10-3) (X10-2) % (xlO-’) g proteins g — Utirik Males. Age ~L540

2108 ~ 6.23 2.36 2.36 0.50 0.75 2*4 43 M’& 2135 9.20 5.06 3.13 0.46 0.46 0.92 45 % u 2137 3M 5.61 2.75 2.52 :. lJ 0. u o.% 42 467 14.8 8.0 2150 257 :.9J 3.83 2.65 . O*2I 0.0 44 4$)2 16.4 7.lb 2156 3*W 1*3 0.24 0.19 0.0 lb5 455 16.4 7.2 as’? 4% 5:81 2.91 2.56 0.23 0.12 0.0 409 15.2 7.4 2121~ 7.68 3.69 3*53 0.23 0.23 0.0 ;; 487 16.4 7.1 ~~ 6.44 3.35 2.64 0.39 o*06 0.0 512 17.4 7.7 2235 8.14 3.91 3.74 0.08 0.33 0.81 c 1.6.4 7.5 2152 z h.60 3.22 1.10 0.09 0.18 0.0 45 ;g L6.4 7.8

342 6.55 3.42 2.55 0.27 0.26 0.48 4.4.6 460 16.2 7.6 ?* $1.47 20.76 B.85 :2.5 234 ?0.7 :0.4

Utirik Females, Age >15-40

2L04 375 5.84 3.85 1.69 0.06 0.23 0.0 36 g M.8 7.8 2U9 95 2.55 2.84 0.06 0.35 0.0 40 13.2 573 2:; 3.91 3.99 O.M 0.33 0.0 30 4ti 10.0 ::: ~ 412 8.59 4.81 3.09 0.43 0.26 O*O 37 408 13.6 7.6 400 6.13 2.15 3.13 0.43 0.31 1.23 37 @ 12.8 7.7 2M8 398 6.29 3.33 2.70 0.06 0.19 O*O 35 3@ U. 8 zt6k 324 9.51 6.94 2.09 0.19 0.29 0.0 415 14.4 i:; 23.72 w 5.82 2.74 0.23 0.41 0.0 R 436 14.4 7.5 2189 417 8.25 ::: 3.63 0.33 0.25 0.0 IQ 438 15.2 2195 5.32 3.19 2.02 0.1.l 0.0 0.0 408 13.2 2:: 2217 5.18 1.73 0.14 0.14 0.0 z 276 10.3 6.6 2:: 2.49 0.2’7 0.14 0.0 445 15.2 7.5 2246 9;25 ::: 2.59 0.09 0.0 :; 435 14.4 7.7 222 8.17 3.92 3.35 ::2 0.74 0.0 36 13.2 7.8 lb13 7.73 3.63 2.40 0.39 1.16 1055 35 E u.8 2249 683 5.61 2.% 2.19 o*39 o*17 0.0 n 425 13.2 :::

410 7.17 3.95 2.67 o.~ 0.32 0.17 37.1 405 13.2 7.6 :97 ~1. 39 ?1. 35 ?0.66 23.6 :41 ?1.4 :0.4 64

Subject Plste. WBC Neut. Lymph. Monoc Rosin . Bsso . Hctc, MC Hgb.~ Serum No. (X10-3) (X10-3) (X10-3) (X10-3) (X.LO-3)(flo-3) (X10-2) % (xlo4) g protein, g

– Utirik Msles, Agew40

2101 296 11.80 6.37 4.96 0.24 0.24 0.0 38 13.2 8.4 2L05 3n :*Z 4*3 3.19 0.26 0.76 0.86 40 3 15.6 8.0 2U,0 437 ● 3.39 2*55 0.06 0.(% 0.0 42 14.8 317 1.60 0.1.1 0.63 0.0 40 3! 14.b l; 2314 * ::~ ;:: 2.94 0.0’7 0.59 0.0 45 16.0 8.o 3.05 1.95 0.16 O.u 0.0 42 $% 14.4 8.0 G 8:% 3.77 ~.$ 0.17 o.51 0.0 453 14.8 8.6 ~b5 7.77 3.19 0.39 :.4J 0.78 z 425 14.8 7.6 2148 3 5*9O ;*Z 2:36 0.35 0.59 42 435 15.6 7.5 ZM56 352 5.91 2. 2S 0.32 o: e 0.59 454 15.2 7.3 ~ ~ 15.a 3:03 2.97 0.19 0.C6 0.63 :; 410 14.4 7.1 3.95 L.w 1.82 O.ti 0.08 0.0 396 14A 2181 27; 7.19 4.53 ;.% 0.36 0.43 0.72 : 368 14.4 i:: 2.48 0.11 0.61 0.55 3.2.1 7.5 368 ::; 2.97 2;n 0.61 0.20 0.0 :; ;% 16.o 7.8 323 5.35 2.46 2.41 0.37 0.05 0.54 42 445 15.6 7. k 2214 * 2.55 2.29 0.05 0.20 0.0 43 493 15.2 7.5 355 i:% 3.44 4.23 0.3.8 0.97 0.0 41 459 15.2 7.8 2253 * 8.77 5.35 2.81 0.26 0.35 0.0 43 442 15.6 7.7

mean * 6.88 3.49 2.80 0. a 0.9 0.28 41.3 428 14.8 7.8 +73 z1.85 . ?1.09 ~.91 :2.2 :36 9.9 +0.4

Utirik Femles~ Age~40

2139 6.62 38 410 13.6 8.0 211 2.01 0.05 0.16 0.0 39 419 14.8 8.0 2:2 ::% 3.73 0.(% 0.19 0.0 39 415 14.4 8.0 =62 :.: 3.01 0.21 O*4 0.0 35 J98 12.4 8.3 2182 ?: z 2.92 0.10 0.14 0.48 33 383 =.8 8.0 2191 7:43 1.63 O.= 0.= 1.49 35 359 13.2 8.3 2193 6.q % 3.04 0.06 0.06 0.61 39 s 14.0 7.3 2196 9.13 3.65 4.47 0.55 0.46 0.0 414 14.4 6.85 ;.2# 2.81 0-9 0.48 0.0 2 430 14.8 ::; 8.47 4.32 0.25 O*9 0.0 $ 402 14.0 7.7 2215 8.59 4h2 3.87 0.34 0.26 0.0 480 14.8 8.2 2216 4.o1 3.01 0.31 0.39 0.0 9 416 14.0 8.3 ::: 5*M 1.96 0.16 0.16 0.0 37 395 13.2 3.17 1.80 0.3.2 0.84 0.60 35 359 12.4 N 2238 ~:z 4.20 3*94 O.ti 0.44 0.0 13.2 8.7 6.27 2.19 3.57 0.31 0.13 0.63 ~ % 14.4 9.0

356 7*O8 3.47 3.q 0.22 0.32 0.25 38.0 44)5 13.8 8.1 P :1.30 ?1. 13 -@.$@ :3.1 :28 9.8 -m. 6 APPENOIX 5

ImiitidualHeaatologic81Findingsj1964

Subject Plate. WC Neut. LymP& Mono. Eosin. 6SS0. Hct.? Hgb. No. (xlo-3) (X10-3) (xlo-3) (xlo-3) (X10-3) (X1O-3) (X1O-2) % g

*ongelap ExPOaed Malesr Age 10-1S

2 430 7.65 3.52 3.52 0.15 0.31 1.50 * 13.2 396 3.2.03 6.13 3.85 0.48 1.44 1.20 12.1 3 ● $ 365 6.25 3.13 2.88 0.13 0.13 0 Q $ ~=1 19 ~ 4.~ 1.92 1.02 0.19 0.75 0.0 43 32.8 23 7.40 3.03 3.18 0.0 1.U 0.70 39 z2.8 32 * 9*1O 3.09 o*18 0.46 2.70 39 =.8 368 7.35 2*~ ::; 0.29 0.59 0.’70 57 u.8 Z* :. g 4.32 3*68 0.0 0.0 3J K*4 &* %. 2.49 5.76 0.26 ::% 0.0 12.8

374 8.01 3,3 3.fl :35s.9 0.19 0.68 0.76 :2.10 :1.27 L17

Ailingnae Exposd Malesr Age 10-1S

6 328 7*55 3.17 2.87 0.45 O** 0.80 37 3.2.1

* 7.55 3.17 2.87 0.45 0.9 0.80 37.0 U.1 Rongelap Exposed Feu&s, Age 10-15

6.35 2.67 0.13 O*W$ 0,0 39 13.6 z ::% 2.52 0.07 1.33 0.70 42 13.2 ;:$ 4.83 O.og 0.52 0.90 40 14.0 E 9.20 ::: b.lw O.w 0.46 0.0 37 13.6 7.40 3.85 2.29 0.15 1.04 0.70 9 M.lb ~3 6.60 3.o4 3.3o 0.07 0.20 0.0 41 K.8

w 7.53 3.39 3.34 0.1o 0.65 0.9 39.5 13*3 :Uo :1.1o ZO.52 :1.06 ?2. 4 +0.3

Ailingnae Exposed $emales,Age 1O-M 454 11.08 k.87 4.87 o*33 O.* 1.10 40 14.0 kb54 U.(28 4.87 4.87 0.33 O*@ 1.10 M.o 14.0

63 66

Subject Plate. W2C Neut. L-• Mao . %oain. 28s0 , Hct ., Ngb.,

No● (xlo-3) (xlo-3) (xlo-3) (X10-3) (xlo-3) (flo-3) (xlo-2) % 6

. Rongelap 2xpoaed Hales? Age >15-40

10 U.30 6.20 o* 57 0.79 0.0 46 14.0 20 z 7.83 5.m ;:: O.n 0.39 0.80 16.0 27 256 7.00 2.9 O.q Q*4 L40 : 14.8 35 lXJ 6.20 X 3.* 0.25 0.60 ~ 16.0 36 y.6J 6.15 0. a 0.74 0.0 13.6 2.75 ;:6; 0.23 O.la 0.60 45 15.6 z z; 7:53 2.33 0.08 0.08 0.0 40 13.2 Ib7 305 8.543 2.72 ::$ 0.17 0.17 0.90 15.2 73 3L5 8.* ~.~ 3.56 0.33 0.33 0.80 ~ 15.2 76 w 10.90 5.01 0.33 0.9 0.0 13.6 77 330 5.32 2:39 2.23 o.ti 0.53 0.0 29 14.0

2i37 8.12 3*W 3.42 0.25 0.43 0.46 43.8 14.7 :~ 22.10 :L44 :1.08 25.5 :1.0

Roqelap ~sed Females,Age >L5-40

12 395 6.45 2.45 “3.81 0.06 0.06 0.60 41 13.2 14 355 7.15 4.22 2.65 O.~ 0.07 0.0 36 1.2.1 15 7.75 3.33 0.47 0.39 0.0 38 13.2 3.8 z 6.93 ;.% M ::: 0.28 0.70 40 13.6 24 6.o5 3.% 0.61 0.0 42 3 7.55 2:79 3.85 0.23 0.53 1.50 37 ::: z 8.25 5.20 2.39 0.17 0.50 0.0 12.8 61 t; 9.03 5*69 2.61 o.ti 0..54 0.0 g 14.0 64 295 2** 3.20 0.28 0.43 2. Lo ~ g.: 66 448 ;:: 67 295 8.20 k.~ 3-44 0.25 0.25 0.0 42 13:6 n 425 9.00 5.76 ;.7J Q.n 0.27 0.0 40 14.0 72 8.40 2.67 0.17 0.09 0.0 74 z 9.55 ~.a 4:39 O*29 0.19 0.0 k; 14.8- 75 423 14.40 10.37 2.73 0.29 1.01 0.0 39 =.4

~ m 8.25 4.32 3.31 O.& 0.37 0.35 40.0 13.1 273 ?1.90 ~2. 13 ?0.96 22.3 ?0.7

Ailingnse 2xposed Fenless Age >1S-40

48 a5 7.13 2.57 3.92 O.q 0.50 0.70 42 14.8 51 415 9.40 4.98 4.04 O.* 0.09 0.0 44 14.0 531 6.30 2.90 3.09 0.19 0.06 0.60 40 13.2 : 320 5.15 1.80 2.32 0.s 0.72 0.50 26 7.6 al w 6.03 2.95 2.59 O.la 0.30 0.0 * 1.L.8

@ 6. 3.04 3.19 Q*2O 0.33 0.36 38.0 Q3 295 *1.% ?l.la :0.77 26.1 :2.5 67

Sub ject Plate● WC Neut. L~ph . Mono. Eosin. B8so . Hct. v Hgb., NO. (xlo-3) (xlo-3) (xlo-3) (xlo-3) (X10-3) (X10-3) (X.LO-2) % 6 — Rengelap Exposed Mslest Agew40

134 10.15 3.65 5.89 0. B 0.30 0.0 15.2 &5 8.LO b.62 2.84 O*(M 0.5’7 0.0 :; 13.2 m 6.33 ~.~ 2. Sb 0.32 0.13 * X2.4 32 6.05 O*I8 0.12 :: z 210 2: n ::2 00U5 1.12 0.0 $ 1;:: 266 ::E 3.08 3.15 0.40 O.q 0.0 44 14.8 319 IL50 5.98 0.46 1.03 1.20 42 14.0 538 8.OO 3.u ::2 0.24 0.48 0.0 43 13.2

33 7.83 3.60 3.48 0.26 0.48 0. 3g 43.0 13.5 :M6 :2.00 :1.a :1.22 t2.7 ?1.9

Ailingnse ~posed Msles, Age>40

H 6.33 2.59 3.10 0.13 0.51 0.0 14.0 235 7*7O 5.24 2.23 0.0 0.23 0.0 $$ 14.0 1.79 3.35 0.24 O*49 1.20 42 14.8 El 2:$ 2.48 3.43 O.u 0.32 0.0 44 15.2

6. s 3.03 3.03 0.13 0.39 0.30 43.0 14.5 ?& -4.80 :1.52 -*. 55 :2.2 :0.5

Rongelsp Exposed Females,Age >40

626 5.h5 2.56 :.: 0.05 ;. g 0.0 10.0 253 9.80 3.72 0.0 1*OO : =.8 295 6.73 ;.~ $:3$ 0.07 0:13 0.0 40 14.0 250 9.80 0.29 1.J$7 0.0 LI.8 250 6.20 2:60 3:16 0.0 0.33, 1.20 :: 13.6 404 3J3.40 7.70 2.39 0.10 0.1o 1.00 40 14.0

M 8.(% 3*74 3.53 0.09 0.65 0.53 37.3 12.7 +9 +2. 20 ~2. @ :1.18 . :3.9 :1.4

Ailingnse ii- sed Fe9sles~ Age w40

313 8.3o 4.4Q 1.74 0.33 L66 di 663 ?** 5.31$ 2.31 0.00 O*M5 ::: lb3 353 2.27 0.05 0.05 0.0 45 w ;:Z ::E 2.96 0.08 ;. 4J 1.60 59 355 10.95 4.81 4.71 0.0 . 0.0

4M 8.06 4.32 2.&j 0.11 0.76 0.02 :148 22.00 ?0. 91 ~1. 15 68

Subject Plate. WC ~eut. LyaPh. Mono● Eosin. Bsso. Hct.g Hgb.~ No. (Xlo-s) (flo-3> (X1O-3) (xlo-3) (xlo-3) (X10-3) (do-z) % g

— Male Children of Ex@sed P8rent(s)~Age -sLO

88 355 10.50 0.32 o.k2 0.0 u.8 @ 395 10.93 ::: ;:?! o*33 0.44 2.20 lb. 4 90 U*OO 5.17 4.18 0. u 1.43 1.3.0 IL8 s 9.05 3*94 0.@ 0.0 12.8 i% 13.00 ::: 3.38 ::2 0.78 0.0 96 z; 15.18 8.35 0.30 L 37 1.50 2:; 97 678 8.50 3.40 pj 0.26 1.19 0.90 12.4 * U*2O 5.49 0.45 1.46 0.0 10.9 M& ~ &k5 2.03 6:25 0.17 0.0 13.2 12.65 6.45 4.43 O*9 1.27 ::;0 13.2 109 Iblo 10.90 4.ib7 0.22 0.55 1.10 U.2 440 9.80 4.41 ::$ 0.20 0.20 1.00 12.1 u 635 ;*3J 1.65 4.m 0.(% 0.64 0.0 113 490 3** ;.;; 0.3 0.78 0.0 ::: U5 400 12:15 4.74 0.@ 0.85 1.20 3$5 10.90 3.60 6:98 0.0 0.33 0.0 M 2 L 65 3.84 7*57 O*K O*I.2 0.(? 1.2.8 1.26 z: 8.60 2.24 5.85 0.17 0.34 0.0 U.*5 130 485 7.85 4.16 2.59 0.24 0.86 0.80 IO*9 131 670 13.95 9.77 0.20 O*H 1.40 u.8 132 470 7.98 2.07 :x 0.16 0.80 0.80 9.7 - 10.33 b.65 0.23 0.73 0.63 Y.2.l ~2.20 :1.38 :1.1

F-e Children of ExposedPsrent(s),Age <10

87 3* 11*45 5.15 5.50 0.31 o*57 1.10 1.2.4 92 9.10 4.82 3.46 0.3.8 0.55 0.90 13.6 9 2; u. 48 5.62 M2 0.9$ 0.69 0.0 12.8 100 :5; 6.60 2.77 3.10 0.20 0.53 O.G 11.5 101 U.05 4.75 5.64 0.33 e. 33 0.0 IL8 103 10.90 4.25 5.67 0.11 0.76 1.10 =.8 105 ;; u.65 5.83 4.* o.b7 0.58 O*C I.&l 106 41? 10.60 4.13 5.40 0.32 0.74 0.0 12.8 108 4$ 13.20 6.34 5.15 0.53 1.19 0.0 u.8 2.09 5.99 0.* 0.95 1.00 u.8 117 63 2:?! 5.44 o*12 0.83 l.m 11.2 U9 37$ 8.75 3.33 Z:E 0.53 O.ti 0.0 u.8 417 10*40 3.74 4.99 0.21 1.35 1.00 U.8 m 531 8.25 3.14 lh46 o*17 0.50 0.0 12.1 m a lJ.6& 6.53 4.62 0.54 1.90 0S.0 9.4 M 529 4.57 5.53 0.11 0.43 o.C 13.2 12J 565 13:48 3.77 9.03 0.0 0.67 10.3 U*7O 3.16 7.37 0.83 0.23 ::& 10.0 134 k? U.. 40 3.42 7.07 0.23 0.68 o .C 135 m 13.65 6.42 5.19 0.68 1.37 0.0 i:i 523 10.96 4.46 5.38 0.32 0.76 O*9 tl19 *L. 90 31.30 fl. 31 69

Subject Plate ● WBC Neut. L)mph ● Mono . Eosb . B*SO. Hct ., Hgbo s No. (xlO-a) (X30-3) (xlo-3) (xlO-J) (s0-3) (Xlo-a) (X.LO-*) % 6 -u ~eed Mtisv Age 10-1S

8%3 405 6.65 2.o6 4019 0.27 0.13 0.0 % 13.2 ~; 285 10.80 5.% 4.43 ~.* 0.32 0.0 12.4 8.05 2.25 5.15 0.24 0.40 0.0 z =8 83.8 9.95 3.88 0.50 0.30 0.0 39 L2. 1 z 5.45 ::g 2. u 0.05 0. n 0 .s0 IJ?.4 :$ 23.20 20.42 2.32 0.46 0.0 0.0 G 13.2 g 9.00 4.59 3.96 0.09 0.27 0.90 40 13.6 922 L2.oo ~fl 3.32 0.3.2 ::1 0.0 36 :.; 933 * $.40 3*P 0.17 0.0 39 ga 335 19.50 14:43 0.39 1.17 0.0 $ 10:6 931 465 13.20 1.98 2:2 0.40 3.83 1.30 L2.4 981 410 K.40 5.58 0.62 1.20 9 3.2.8 1033 613 ~.~ 3.~ ;:$ ::2 0.0 0.0 % 14.0 1036 1% 0.44 0.22 0.0 L2. 4 L052 495 9:40 M 4: n 0.9 0.38 0.0 2 =*1

* L1.13 5.96 4.17 0.31 0.66 0.26 37.4 12.5 3158 ~b.m :5.03 ?1.22 21.7 ZO.8

Unexposed Females, Age 10-1S

805 458 u. 38 4.55 5.35 0.34 1.14 0.0 41 12.1 al 433 up 6.44 4.10 O*L2 1 .05 0.0 35 ~.1 333 8.80 4.14 2.82 0.35 1.23 2 ●60 38 3.2.1 E 334 8.68 3*U 4.e6 0.17 0.52 0.0 u.8 909 5*95 2.32 2.& O.ti ;.7J O*6O 4:7 L2.8 9U 2 8.48 5.17 3.05 O.* 0.0 u.8 925 275 2. n 3.63 0.0’7 0:13 0.70 c $.: 926 360 ::% 6.75 0.24 0.95 0.0 40 937 ~ 1:.$ LO.32 M 0.36 2.14 0.0 37 12:1 M 3*33 3.76 0.24 0.90 40 13.2 955 538 7:80 3.28 o*31 ::2 0.80 39 13.2 959 448 11.05 7*29 2% O*U 0.88 0.0 38 L2.8 * m 9.25 4.16 4.53 0.09 0.46 0.0 ; ~.1 962 3$ 6.70 2.OL 4.02 0.0 0.54 1.30 U.2 9* 7.80 2.26 4.52 1.02 0.0 K.8 8.40 3.86 2.69 M2 1.Jb3 0.0 z :.: 2 14.33 0.57 0.43 0.0 . 1035 M 50 ;:2 M 0.13 1.75 0.0 :2 14.0

9.* 4.74 4.00 0.22, 0.8$ 0.38 %.3 32.4 .+3.00 :2.25 ?0.94 22.5 20.8 Subject Plate. WBc Neut. L~ph . Mono. Eo8in. Baso. Hct.s Hgb.s NO. (xlo-3) (xlO-s) (xlo-3) (X@) (fro-s) (X10-3) (fro-z) % g

Unexposed Males* Age *15-40

822 14.15 10.33 3.31 0.lb 0.57 0.0 14.0 823 1;.% 10.48 0.47 1.41 1.60 13.6 82z ::$ 0.44 0.79 0.0 14.8 82$ 13:28 ;:$! 4.51 0.40 0.0 0.0 15.2 830 5.78 :.9J 2*35 0.06 0.23 1.10 15.2 8= 9.00 4.41 0. h5 1.17 0.90 ti.g 833 6.45 2: n 0.26 0.0 0.0 3.6.0 836 ?. 50 ::; 0.15 0.45 0.0 14.4 840 7.68 t: 2.92 0.08 0=38 0.0 15.6 9.70 0.20 1.65 1.00 17.4 g 9*95 ?:: N o*50 0.90 0.0 14.8 4.19 O.w 0.0 14.8 882 ;:g ;:: ::Z 0.06 1.30 14.8 885 u. 03 6.a9 ::$ O.= 0.44 0.0 15.6 m 7.90 4.03 0.24 1.11 1.60 15.6 918 ‘7*15 ::g 4.(M 0.23, 0.43 0.70 16.0 919 7.& 0.47 0.55 0.0 12.1 939 10.80 $i ;:2 0. U 0.54 0.0 14.4 * 6.15 . 2.40 0.32 O*I,2 0.60 14.4 * 8.55 1.97 O.m 0.68 0.90 15.2 971 18.95 1::2 6.82 0.57 0.95 1.90 15.6 KI05 :.g 16.4 1500 3.13 2.99 0.20 0.48 0.0 L6.4 1501 9:68 6.39 2.90 O*2Q 0.20 0.0 14.8 ~ 9.40 5.10 3.45 0.26 0.57 0.50 46.1 15.2 ~3.40 ?2. 73 +1.15- :3.1 :1.1

Une%posed Peties, Age s 1S40

@ 8.53 3.92 4.18 0.09 0.26 0.90 L2.8 8.25 5.86 1.65 0.25 0.33 1.60 U. 5 10.83 7.14 2.81 0.22 0.65 0.0 L2.1 %! 4.35 2.54 0.07 0.29 0.0 12.4 835 J:z 5.25 4.02 0.10 0.93 0.0 K.4 841 10.40 6.55 0.0 0●& 1.00 10.0 843 6.85 ?:Z 0. lk 0.34 0.0 10.6 845 ::$! 4.20 0.27 0. ti 0.90 13.6 ?:: 4.91 1.83 0.22 0.37 0.0 10.9 z; 8.ti 4.25 0.33 0.41 0.0 u. 1 891 8.33 2.66 ::2 0.17 1.33 0.0 14.4 &5 10.55 4.64 0.= 0.32 0.0 15.6 w 11.m ::g 0.22 O*U 1.10 10.9 93.6 U. 23 7*3.8 2:$ 0.67 0.67 1.3,0 12.1 9= 6.13 3.19 2.21 0.18 0.49 0.60 12.4 932 12.88 8.24 3*35 0.0 l.ti 1.30 U.2 4.41 4.05 0.09 o*36 0.90 13.2 934 0.0 933 1::= 9.14 0.87 Q*U 0.76 10.0 7.05 4.51 1.76 0.35 0.42 0.0 15.6 945 1.30 14.0 ;? 6.50 2.28 3.45 0.13 0.52 903 L84 3.91 0.09 0.37 0.90 13.2 8.80 5.10 3.17 0.26 0.26 0.0 12.1 965 0.0 8.8 977 1.2.95 8.16 3.63 0.26 0.91 10.10 3.33 5*55 0.40 0.71 1.00 u.8 993 0.0 14.0 9s@ LO*88 5.* 4.24 0.54 0.11 la 5.83 3.20 2.04 0.17 0.41 0.0 13.2 1043 3.01 0.35 0.42 0.0 13.2 1050 . ;:: ::$ 2.45 0.40 0.80 1.2.1 1502 12.43 9.32 2.36 $;7 0.25 1.20 Il. 5

- 9.16 !5.29 3.11 0.22 o*49 0.50 37.3 12.4 .+2.00 21.87 ?l.1.l :4.5 21.6 71

Subject Plate. WBC Neut. Lys@I. Mono. msia. Baso. Hct● s Hgb.~ No. (xlo-3) (xlo-3) (X1O-3) (X.LO-3) (X1O-3) (xlo-3) (xlO-Z) % 6

– UnexposedMales, Age *40

w 3.47 3.39 0.0 0.85 0.0 15.6 853 ::: 3.6s 0.25 0.16 1.60 13.6 856 8.73 M 2.79 0.17 0.87 0.90 =.8 es 8. w 5.36 2.64 0.26 0.26 0.0 15.2 7.90 2.92 4.50 0.40 0.80 13.2 7.80 3*59 3.43 ::;5 0.23 0.0 14.8 10.75 4.19 o.21 0.75 1.10 13.2 8.30 ::: 3.65 0.25 0.25 0.0 14.0 2.97 1.84 0.22 0.32 0.50 13.6 ::: 2.@ 0.25 0.67 0.0 32.1 7.55 {:2 3.02 0. d 0.38 0.80 14.0 5*95 1.84 3*33 0.30 0.36 1.20 3,6.0 7.30 2.% 3.72 0.07 0.88 0.70 14.8 5.63 2.87 1.80 0.23 0.68 0.60 13.2 7.83 3*29 0.23 0.31 0.0 u. 8 8.53 ;:g 0.17 0.77 0.90 lko 7.05 5.01 M 0.14 ::3 0.0 15.2 6.40 2.88 3.14 0.13 0.0 14.0 9.15 5.86 2.’75 0.18 0.37 0.0 14.4

7.75 3*93 3.06 0.20 0.47 0.48 14.0 ?1. 30 $1.14 ?0.78 :1.0

Uaem sed Femaless Age AO

8.93 3.21 0.62 0.0 14.0 8.1o 2%2 5.67 0.16 ::$ 0.0 3.2.1 10.20 4.2$ 4.90 0.20 O.’n 1.00 U. 2 8.00 3.s 4.00 0.32 0.32 0.80 U.8 7.75 2.95 4.34 0.0 0.47 0.0 13.6 10.50 4.20 0.0 0.42 1.10 1.2.1 ::2 2.13 0.3.6 O.’/l 0.80 14.0 ::$ 3.24 2.33 0.19 0.58 1.30 12.1 6.13 2.45 0.0 0.37 9.rJ x2.8 6.65 3.26 ::: 0.27 0.47 1.30 6.35 3.3.8 2.79 0.25 0.13 0.0 ::: 8.93 4.55 0.09 0.36 0.90 13.2 ~.; ::$ 1.69 0.26 0.20 0.0 13.2 . O.q O.ZQ 0.70 u.8 7.53 ::% 2:$ 0.38 0.9 0.0 KL.8 8.60 3*78 4.30 0.34 0.17 13.2 11.80 3.66 7.79 0. u 0.3.2 ::& 12.1 8.40 2.69 0.08 0.25 o.& 14.0 13.05 ::Z 3.13 0.52 1.04 1.30 16.0 7.25 3.77 2.* o*36 0.44 1.40 13.6

360 8.29 4.01 3.60 0.23 0.40 0.63 13.0 299 ~L.9 :1.41 ?1. 45 x).6 72

Subject Plate. WBC Neut . Lymph● Mono. Eosin. Baso. Hct., Hgb.9 No. (xlO-S) (X10-3) (xlo-3) (X10-3) (xlo-3) (xlo-3) (X10-2) % g — Male Children of Unexposed Parentsy& ● <10

8.83 ;.$ 4.85 0.09 0.62 0.0 13.2 g 1o.68 4.91 O*2I 0.0 : 13.6 U.95 ;:g 2.99 0.24 ::: 1.20 * 12. b W7 13.58 5.70 0.2’7 2.17 0.0 36 12.4 w 8.90 3:56 3.56 1.b2 0.0 35 L 5 870 5.85 2*U 3.16 H 0.41 0.0 u.8 904 11.oo 5.28 4.84 0.44 0.44 0.0 z ;;.; 905 lk. 53 10.60 0.15 0.44 1.40 37 952 1.6.40 6.40 ?:: 0.49 1.80 0.0 37 li 4 :002 14.45 7*95 4.05 0.29 2.02 0.14 35 u.8 1004 u.83 5.13 7.3 0.26 0.13 0.0 37 12.4 1006 16.90 8.28 :.9J 0.68 1.01 0.0 37 u.8 1009 8.o5 3.70 0.40 0.40 0.80 N 12.4 1o1o u. 50 7: n O*I.2 o*35 1.20 37 E. 1 1o13 9*9O ::; 3.07 0.10 0.0 34 10.3 1014 8.60 4.64 3.10 0.09 0:; 0.90 42 1o18 12.80 4.99 5*25 0.26 2.18 1.30 s:? 1024 8. w 4.68 3.15 0 J? 0.68 0.90 $ u.. 5 1026 11.15 6.02 O*U L.* 0.0 34 u.8 1027 9.15 i:% 4.39 0.09 0.37 0.0 39 U. 5 1030 9.65 0.39 0.48 1.00 $ 12.4 1o37 8.03 ::$ ::; 0.24 0.72 0.0 37 12.4 1038 10.70 6.10 0.32 0.11 1.10 10.6 1039 43 14.10 ;:: 6.49 0.28 0.42 0.0 E 12.4 1040 603 9. s 5.17 3.54 0.29 o* 58 0.0 37 E?. 1 1046 10.45 5.85 O.c 0.63 0.0 34 n. 2 1047 k: 17.70 H! ;.: 0.53 0.35 1.80 10.6 w 11.15 3.22 . o.% 0.11 0.0 g u.8 1053 490 8.25 3.47 0.17 0.50 0.80 12.4 1054 225 13.80 4.97 ::% 0.41 0.41 0.0 39 14. k 10%! 8.20 2.54 ~.76 0.49 0.41 0.0 37 14.4 1503 ~ 12.25 3.80 8,33 O.u 0 J? 0.0 40 13.6 1504 11.95 4.42 6.69 0.60 0.24 0.0 37 1.2.8

470 u. 34 5.03 5.24 0.28 0.66 #34 0.9 37.3 12.1 22.80 tl. 98 ?1.77 :2.4 30.9 Subject Plate. WBc Neut. Lymph. Mono. Eosill. Baso. Hct., Mb. , No. (X10-3) (X1O-3) (X1O-3) (X10-3) (xlo-3) (X10-3) (X10-2) % g

—Female Childrefrof Unexposed PsrentsVAge <10

810 461 8.40 4.87 2.52 0.84 O.d 0.s0 L2.8 866 203 6.20 2.42 3*35 0.(% 0.37 0.0 u. 1 901 19.50 11*3.2 7.41 o. m o* 59 1.9s 10.9 902 3 9*9O 2.97 5.25 o ●o 1.68 0.0 10.9 419 13.80 8.Lb 4.55 0.41 0.69 0.0 M.8 g 455 7.83 2958 4.54 0.08 0.55 0.80 u.8 423 10.65 5.33 4.3 0.43 0.43 1.10 u. 8 930 651 8.6o 4.30 0.09 0.43 0.0 12.1 954 328 U.* M 0.23 0.0 K.4 979 386 9.70 4.66 ::; 0.0 ;:87 0.0 13.6 995 350 8.30 2.74 ● 0.33 0.58 1.70 12.4 10M n. 45 4.24 0.34 0.92 1.10 12.4 10I2 ?; 7.20 2.23 ::$ 0.14 0.29 0.0 12.4 103.9 373 I.1.lo 6.22 O.u l.m 1.10 IJ..2 14.85 ::$ 5.ZQ 0.0 0.74 1.s0 g.j 1022 k? 8.2o 2.87 5.17 0.09 0.09 0.0 io25 635 13.73 3.29 9.7b 0.14 0.27 2.70 13:6 1026 u. 15 3.68 6.02 O*U 1.34 0.0 u.8 1029 z 8.75 2.36 5.95 o.18 0.26 0.0 10.9 I.m 525 10.90 3.60 6.32 0.22 0.55 2.20 3.2.4 1034 410 9.40 3.57 4.93 0.9 0.9 0.90 13.6 low 635 U.03 3.86 6.28 0.33 0.55 0.0 9*7 lo!n u.a 4.03 6.50 0.34 o*22 1.10 13.2 1057 :$ 12.60 3.78 7.94 0.9 0.50 0.0 10.6

me- 468 10.67 4.20 5.47 0.23 0.62 0.70 36.8 1.2.I ~133 :2.80 22.10 tl. 50 22.4 ?1.0 APPENDIX 6

Individual BasopbilDeterminations,1963 and 1964

% 3as0./4OOOcell count % Baso./4OOO cell count Subject Subject No. 1963 1964 No. 196s 1964

1 0.45 0.40 63 0.30 0.50 2 0.65 0.75 64 0.40 O.@ 3 1.00 1.60 65 0.45 0.23 4 0.52 0.75 66 0.30 0.52 0.50 0.55 ~ ---- 0.23 2 0.38 0.30 0.35 0.20 0.40 0.30 69 0.9 ‘o.23 i 0.55 0.62 70 0.25 0.18 9 0.42 ---- n 0.25 0.% 10 0.65 0.58 72 0.58 0.32 u 0.25 0.50 73 0.72 0.3 12 0.38 0.50 74 0.20 0.25 13 0.58 0.52 75 O.la 0.35 14 0.72 0.55 76 0.25 0.28 15 0.30 0.42 g 0.32 0.20 16 0.25 0.30 0.20 0.23 17 0.35 0.30 0.35 O.& 1$ 0.60 0.45 ~ 0.25 o. La 19 0.50 0.52 81 0.42 0.20 20 0.55 0.58 82 0=9 0.30 21 0.45 0.50 83 0.15 0.23 22 0.30 w ---- 0.% 23 0.30 0.25 85 0.13 . ..- 24 0.48 Q*3 0.42 ---- 27 0.52 0.29 % 0.48 0.45 28 0.42 0.30 0.48 0.25 a 0.30 0.% ; 0.30 0.* 32 0.52 0.60 90 o* 40 0.38 33 o.k5 0.9 0.28 0.30 34 0.48 0.50 % 0.20 0.25 35 ---- 0.30 0.40 0.15 36 0.25 0.23 2 0.18 0.23 37 0.45 0.30 95 0.25 ---- 0.50 0.40 96 ---- 0.48 E 0.55 0.50 97 ---- 0.52 41 0.50 0.50 * 0.45 0.35 42 0.60 1.05 ---- 0.35 43 0.62 0.45 ;E 0.45 0.50 h5 0.52 0.70 102 0.38 0.58 k7 0.40 0.45 103 0.42 0.25 48 0.55 0.48 104 0.48 0.38 49 0.50 0. b5 lo5 0.42 0.% 50 0.35 0.30 106 0.30 o.1$2 51 0.45 0.9 108 0.35 0.45 53 0. -* 0.50 109 0.25 0.55 54 0.25 0.50 I.lo 0.25 O*M 55 0.50 0.45 0.42 0.50 56 ------u 0.50 0.38 57 0.25 ---- 113 0.55 0.50 58 0.20 0.30 3.15 0.25 0.L8 0.20 0.25 U6 0.35 0.28 2: 0.28 O.m 1.17 0.35 0.40 61 0.48 0.35 U8 0.42 0.40

74 75

% Bsso./4~ cell count % Baso./4OOO cell count Subject Subject No. 1963 1964 No. 1963 1964

I.lg :*5J! 0.45 8k3 0.35 0.2 . 0.20 w 0.38 0.23 121 .-.. ---- 8L5 ---- 0.38 122 0.38 0.25 846 0.30 ---- 1.23 ---- 0.25 w 0. b 0.23 I@ 0.45 ---- 851 0.40 0.35 125 0.28 0.40 852 0.30 0.28 l% 0.23 0.25 853 0.28 0.28 lzJ 0.40 0.28 855 0.28 ---- 0.25 0.28 856 0.23 0.23 130 ---- 0.40 853 ---- 0.25 131 ---- 0.32 859 0.30 0.20 132 ---- 0.40 862 0.25 ---- 133 ---- 0.23 863 0.20 0.28 134 ---- 0.25 864 ---- 0.L8 135 ---- 0.25 %5 0.35 0.28 801 0. a 0.30 866 0.30 0.25 0.30 0.30 867 .-.. 0.20 z 0.42 0.23 ---- 0.25 805 0.30 O*X E 0.38 0.20 806 0.35 ---- 871 0.23 ---- 807 0.50 0.35 872 0.20 ---- 808 0.23 ---- 873 0.26 ---- w 0.15 0.23 874 0.18 ---- 810 0.38 0.28 875 0.40 ---- 8U 0.25 0.23 878 0.30 0. 4Q 8X2 0.48 0.40 880 0.2$ 0.25 813 0.30 0.30 /?81 0.9 0.20 814 0.25 0.2U 8a2 0.42 0.35 0.23 0.20 883 :*YJ ---- E; 0.23 0.28 0.42 818 0.28 0.40 885 0:30 0.38 819 0.40 0.38 886 0.25 ---- 820 0.52 0.40 891 0.23 0.25 821 0.32 0.20 ---- 0.30 0.23 0.28 E 0.35 0.30 :E 0.30 0.23 w 0.55 0.23 8232 0.18 -..-- W5 0.32 0.30 0.25 0.32 896 0.50 0.9 827 ---- 0.15 &37 ---- 0,jo ---- 0.45 898 0.25 0.28 & 0.28 0.35 899 . ..- 0.35 ---- 830 O.* 0.% 9 0.30 8S 0.20 O** *1 0.35 0.28 :; 0.15 0.25 0.35 0.18 0.23 0.18 0.25 0.32 834 0.32 ---- 0.;8 0.22 835 ---- 0.25 3.20 0.25 836 0.30 0.30 0.25 9.35 83$ 0.35 ---- 0.35 0.35 840 0.* 0.35 0.42 0.28 M 0.28 0.40 0.38 0.52 842 0.50 0.30 0.45 0.28 76

% Baso./4ooo cell count Subjeti ~ % Base. /4~ cell count No. 1964 S“;:e=t ~ . — 1964 0.25 0.9 0.45 ------% ---- 0.20 O*38 0.30 0.28 0.35 0.30 979 ---- 0.28 ---- .-. . z ::% 0.42 0.45 0.35 0.30 0.52 982 ---- 0.40 ---- 0.30 0.9 0.30 0.35 0.25 0.35 k; O.h 0.35 995 0.28 0.35 0.26 0.25 0.40 0.25 0.23 0.25 0.28 z ::Z 0.30 1001 0.30 0.32 ---- o.3a 0.23 1002 0.38 0.38 mo4 0.35 0.35 0.30 0.48 0.30 10C6 0.25 0.23 0.25 0.30 1007 0.30 0.32 0.32 0.23 0. la 10C6 ---- 0.38 loog 0.50 0.42 0.30 0.30 0.23 0.30 ---- 1010 0.38 1o11 ---- 0.28 0.30 0.30 0.35 ---- 0.35 # 1032 0.38 1013 ---- 0.23 0.32 0.25 0.28 ---- 1014 0.23 1015 0.30 0.40 0.23 ::$ ---- 0.38 1017 0.3 ---- 0.30 1018 ---- 0.32 0.30 0.25 1019 ------0.40 0.25 1020 0.30 0.20 0.25 0.38 $2 ---- 0.32 % 0.38 0.40 0.32 0.28 1024 0.2% o.k5 0.25 0.40 1025 0.40 0.26 0.30 0.30 1026 0.25 0.35 0.30 O.lbo loa ---- 0.42 0.30 0.28 1028 0.35 0.26 0.25 0.18 lo2g o*30 0.35 0. B 0.28 0.25 0.25 lop 0.35 0.25 0.52 ---- 1o31 0.35 O.y) 0.40 0.32 1033 0.40 0.32 0.30 0.2!5 1034 0.30 0.28 0.45 1035 0.35 O*38 ~.% 0.35 1036 0.30 0.38 :: t 1037 0.38 3.29 ::: 0.50 1038 0.23 0.23 ---- 0.30 1039 ---- 0.30 ---- 1040 0.28 O*35 ::: 0.30 1041 0.25 0.25 0.30 0.38 0.40 0.25 0.25 0.25 k% 0.23 0.28 0.30 ---- 1044 0.23 0.30 ---- O*25 1045 0.28 ------0.32 1046 0.32 0.30 1047 0.38 0.30 77

% Basos/4~ cell co~t % BasOa/4000 cell co-t Subject Subject No. 1963 1964 No. 1963 1%4

---- 0.38 m4 0.20 ---- 1049 . ..- ---- 0.25 2266 0.23 1050 ------0.25 2167 0.25 105I. ---- 1052 ---- 0.28 2168 0.;2 ---- 0.23 2169 0.38 ---- 1053 ---- 1054 ---- 0.30 2172 0.30 ------0.20 2174 0.30 1057 ---- 0.30 0.30 =75 0.25 15CQ ---- 1501 0.23 O.a ZL76 0.32 ---- 1502 0.2% 0.28 2179 0.20 0.10 0.20 2181 0.40 ---- 1503 ---- 1% 0.28 0.20 2182 0.35 0.45 ---- aol 0.25 ---- 2186 ---- 21.02 0.32 ---- 2188 0.40 ---- 210k 0.23 ---- 0.30 --- aos ---- 2191 0.40 0. P --- 2106 0.35 .--- 2193 0.42 2195 CI.25 ---- .2@ 0.70 ---- 2196 0.30 ---- 21.I.O 0.30 ------2197 0.25 ---- 0.40 ---- 0.30 ---- 0.35 ---- 0.25 ---- 2113 0.9 ---- 0.25 ---- 2210 0.60 23A4 0.40 ---- 23A5 0.50 ------0.30 --- 2U9 O.@ ---- 0.23 ---- 2213 0.20 2214 0.30 ---- 2324 0.30 ---- 2215 0.32 ..-. 23.25 0.25 ---- =6 ---- 2126 0.30 .-. . 0.9 ---- 2217 0.25 --- 0.38 ---- O.* ---- 2218 0.35 2221 0.38 ---- 2130 0.35 ---- 2224 o.h5 ---- 2135 0.40 ---- 2225 0.25 ---- 2136 0.25 ------0.25 ---- 2137 0.35 ---- 2=J 0.32 ---- 2138 0.30 ---- 0.30 ---- 3.23 2140 0.28 ---- 23.42 0.38 ------2235 0.30 ---- 23.45 0.40 ---- 0.30 ---- 2238 0,23 ati 0.30 ---- 2148 0.45 ---- 2240 o.lb5 ---- 2242 O*9 ---- 2149 0.38 ---- ‘23.50 0.35 ------.-- 2246 0.23 ---- 2151 0.25 ------224 ;.$ 2152 0.25 ---- 22J ● 2155 0.35 ------2249 0.30 ---- 2156 0.32 ---- 2251 0.9 ---- 2M7 0. s ---- 2158 0.35 ---- 2253 0.30 0.25 ---- 2160 0.30 ---- 2255 ---- 2256 ()*~cj ---- 2162 0.30 78 APPENDIX 7

USICST ?msm m., Pm HS2GiiT - Pltususs ~ )&Z, SR ?iIs’za? U1.mmrzs arzmm QJ2AST 6 L~s m Gu or Gpm sKm — . — - — — - Obority. URI. 1 Ftitioo lax 157 193/lCO mcular d9g9n*n ~ ~me=wle . ~n-~~ -c a. albw. Grav. 12, ~. KYw-Mim. tlm and kozi - @bF :2. CUlar Cpcties. r P-uygim and u LRI, c-. -U. b,p. dlatai u+~ 2 cm. :y8t Xl 128/80 lent icular lmck over ~; nild POLLO’63. ~ l*ft 4J3!4 ~ities bi.lat. r~ iadu firgcr. Arc’Ul4+. Nrglcally.

B2Mt. ptarygim 7 Arcu9 1+. sllat. Sllghtly 128 20/ rl! L5il @ nti enhrgad prcsmta .’ K.I*S.

9 2X. of $ricb-. i56 u61T0 Str8bl~s . 1’ 32 !4

10 Rwium 139 LIG/@ laft *y,. 34 M

ArsY2J.,-Robrxm 24XUScmrr r?,. L1 SLwt pmz) am Us/w plIp~ bi.let . shaLd*r md atiffnws in Eyprt*Mim Pt*nTJium hft chest , hemling 6CM >Oinw . IJ.2 L?o/ux ’63 w. 3+ m~m I Ulcer i-t. W* amerimclmoais (trmt.d). Reai - t iusl “baa bun. 12 kWmrchc W, 13. Palm 5, grin.+. 12’7 ’63 IJO/?G’62 Choroidlt la ,IPregt , 20 Navim 28 F IMPJuw 1962. l-t. 9P. pelvic L* 3. back 843.

MOnqnusc 8.s. Strnck in left R.E. : 20/70, Oki 13 43(?). Mrm o, am 7-8 you, T6 x8/& Choriorotinltis , grsv. o. %Or ago, ulce~tion. arm , lenticlucu 68 F Vlaion. a~ity. L & :20/ K?J, S?.aphylca 5X6 ecdcx&bdmi tls. 1,

lb IMP 3/63. “S@ta bum ‘ 127 -90/60 ~(?) scus m. elbr. 35 P ~5~95~33” left em. left axilla, ar , left reck.

:6 12$ X@56 ArcUl 2+. Rt. Roatate l+. 49 M pte~ila

w-ho aga 12. Plcgwcula *, ktccale , 18 II@ L/63. mrs. ptarYglUm left. cymtccele. 13, gmv. 12. ma loQ/ 6a m-t mflalmd. , Zed@d :*rvlcal 31? tiwt~ Lo/63 kez’atlonl. to prn.nt .

22 Ccugb. 101 ‘42 95/60 ’62 ~? X3 ’63 8k/yo 163

2b 140nu’cham 12. .mr.tied iepi,q, Far& 2, 5nv.2. 104/68 - ncdes .~mx of >eck. 23 F Itch2.ncj of tkl.n. 1% ’63 right neck. 3i0pay scar P.. .ACF.

27 1J41 lc6/&3 Chos?,pin. lYJ ’63 me 52[mul. Y5M Zl%dycal-dia

28 .!lenopUs@:nge%l. u :38/68 p!l.lle 32, Arclls .+. M. iO, WV. u ,61 mm Fterygiu bilat. L-r palpable 10. LfRI. L&J/W ‘63 senile 2ata - one finger 78 F WV90 q62 racts, bflat. breadth . \ Indftidual Atilt Physical Findings 79

mQm mMuT2& Cmwm U Ok% Urim9, ?4p., MNcmu222ms, I MxOICuEICAL,lmlus, 2’22. U=C m? PPAT X-fq, ccc. XxonmMrxme

e,ya &l xaruim. !mUlt y. —

10,200 43 133 tit X-MY nq. ’63.

—

CmfOnr# uppr L0b8 l*ft eu. lhmcu left buttcck a,m Q P’rwtatic h~opily. ’63. .mck edmk?’pthy. —

7,200 b? :25 1%3 e~tial. No 1* ●nEiJDtim.

. 46 @ e2x 2.2.0 ’63. I

Rab8~ +. 6,3a3 38 -tat bun. .htul.mcbrmti. R=. h tirt. —

6,502 41 395 m 8.8 ’63 1%3 OmmiJmtlm. -tOlcgJ‘mlY1*.

mp. : .mq8t.iVQfcz ~t C*U*; Atrophic vm@!a, n. ky@ic- 5,5m 628 ~tim; o- sq— mypla S1S, right scol.iosis. T.aOr noted; ? trich— qlrmlz.1 Xy@mcolials . Zn.Llmtef= left Zabia 1%3. =e*taticm; hish ●strcgcnic 1.-1 pc,aibh ct. of !mnl at m,lur for 8.2*and Mlmtrud!list0r7.

~t u.lmr ,tylc!id ?,2C0 36 355 m 8.3 ’63. mp. : ~tiw f= bllat. RMgMrIt calls; ~tion; Umbmrricd cdl Qtypia.

M2nimi erteriwluo,is, .- right aarnL14 @is 6,3m u Artmlwclamis. FULS*.%pmttIvw mflu.a. Pr08wtic!gput2Gza7. — I 40 *

7.1 39 1%3 aam.mtica. no Mb ~tim. Y ~ 2-3 mmt.iu ’63.

6,(D3 mck adulwtiu.

I ,,WO 256 i I I SW929 mefioacloruil. .@ad and frnble, art.crloaclom 118, KiLi kyphmls uul right kmoscolloais . EqatanesQy. ●Colitis. ~ rt. I “m Rec. es-t ramonl. ,Qau styloid. 80

U2xom ?mm no. , PAST Emx2 EOOD?~ AsDam &x, m nxsmr mm us arrm2Yn2 UT b LLms m ‘al or Gym ssm

29 Sllnd in loft Uo U.O/a ●& Qism m Run 80,rw. Rt. Catumct FTcStstc 2+, 75M hm-mm. rum lam. lob. Z4ft q&klA.

A?cU9b. brt Ntd-1.ha Nrg. [email protected] moles * ~-bm- 126 lWTO ptu-y@m. Ii-t. #car. -Ian Mck and nack. taractz ‘w. X4--- 02 ce27ix- 55 ? mn. lb,m. 1+ mtmd stir . lo.wa la 1s. c!alm.

35 23 H 2.25 ’52 u.o/60 ’62

36 ‘nlrIxts12,.#lt X.nea Clr’clnau 18 M 134 L15/Ea ~tloa. &k, sM. , legs and axmc.

37 lb6 120/70 Are’U#1+. pn ails..p~ 1.

2.1.rmgbanb2 33 Colmti a- amd9is. Mck Cf 109 “62 90/60 162 la2t w ’63. neck. u. %ar. 25 ? and ol. hwrQls. ~ *t Flstnlaiaam ~ic &* - bo (Correct 9d Nr- it7 rw bales 125 Arms z+. Fistula la ma mtiti* gicdy ‘6b). rinser. U5 ’63 uo/ro wlgwmbOMd with pwrirwtti right lnnd. 39M M btck pmin. -=-. -bscsss ‘53. Xmkopitii- ‘63. U’cw 3+.2+ mt : &l - nrtOr’lO- Z r*t m U6 210/70 W21uaia. cm== . 5k H *9tl.luY T14 or chorold daswmq tlal. lust . pt8ry15is , ~3 ~: t- 6a 130/72 Blz.st . ca~s , unknown. -. G** I qm. a. -t nlisht 76F lb, grav. lb. ~tloll.

lb5 ~~ w 13. AI’Cu#2+. Ldt m 3/7/64. Fmm. Uif 120/7u P~. 42 r u, @sv. 9. b Rightptaygi= tackm.

b’f Uuat #12@t 135 lLo/70 ~t 1C5. tin

MmmluqOl 3. 166 ~. ~ w m 2/5/6Jb. sum . m ’63 *@ -t ~. ● -- -m h< 6, ~. 3. m Cerrica.1 turn. 2s> m @2at8, Obau , L13 cm. cerYlc* ● rOa ion.

50 A1-.xu3+. - 2ars on uwer 165 129/70 no,eaopts rt. am ino: UK “beta bums” ‘.

51 mlluClmts91 7. m. 2, .qrw. o. 99 90/&2 mod Cervical 35 F w 3/7/64. tc. =hol.in Cwt left labia

53 [email protected]. slilXl- nocs, -id. 85 M 81

I I I 1 SxMu m9mzs6 mmzs us Mm, Urixm, h?., lmxmumms, ~z’xas msma.a21aL. ms=s,x=. = Em PIN X-rw, ● te. — I I I I I I I

6,.2w b9 162 chwt x-my nqsti- 1952. II

10,6CQ u 2.L8 chut x-my nO@tim 1%3.

>,&lo b5 285

Q? Ch99t X--Y mti- 1962. 1563 am8.1.mtim. 7,620 37 miu 1* e~ticm.

k25 mast x--r nOl@1- 1%3. Surgicsl CCmwction fl@3J2S T,5C0 @ la Mo.

I I I 1 82

U2ZmIT Pazm m., ?A2T EcoD P22SSV22 ABDmu2 Km, 2U SI~T mmmzm Cl%%2R2 R2MT k LUXX 2UT Cu or Gym mm — 57 19/?0 ’62 Vls. LP. 163 ~ P-, AXterlmclu.mi, mtuuta o 9763 LLo ? %/@ ’63

58 h— ,mbis - ~o w ‘9+. llo L2tJ/E6 ,lert Ca-?. Atrophic va@na, mlas frczlt ru’s.u, gmv. 10 103 ’63 bld Iuriag md oido of 69F it Lu . -t exu. nack .

59 tiqausa age 41. FUa. z,glw. 1. 82 U@ro Q? But. Chomidsl aLcu2 at Eio$ay scar Ol?xWMlcOu@l. ~tlm. Cen-lcal m. bck. m both breasts

60 ihnopusc w U5. 138 15W0,1W75’63 Pm-a.o, gmT. 3. lb? $63 6.5F -ml.. Atrophic %10 on mm. -h #~02.iC N. qlna. forehti.

61 *mrcha W* L2. 168 L MP 2/15/6k, l% ’63 1.20/76 18 F =.fsm.~ Cenical er-ion Scar right am. 2,g2W. 2. tbrcst. ’63. ~Q. bmut. liYW’63.

63 51UpcyS* ~q~. laft Mck. 46? k.13,.gmr.lo. LL5 12cl/60 -. P*. W neck. mmrch, -o 12. & L MP m~ 1%3. Ildo bsck cf W.Lo,@mv.g. 157 llo/?o 2 pt~um kJF Uterus enbrge.i reck; sl. pig. ktatiag Siaca right ●w. 5.0 cm dti. vu. front Or m~ 1563. sock.

a -5%.’3” 139 210/70 * 2+. Livur * -p. PUm.o,!grw.o. Zaf’t pt~ilm. 1 koF 9 B. m. Sc8r rl.ght Lsbti.

6? mmrcm * 13. “bta burn” L M P 3/10/6L 127 Zk F noplvic m. SC- dormim mm. o,gzw. o. wit %ht calnd. 1- left ft. I Rt. rdght OnLy. 68 mm in Lqa 132 30/eo Ldt 20/&o. R. Rwtati 2+ d fn’t. peer Lt m murld. Awti, hft 5514 aim ●e Catarwt.

70 mmrcha m m. L15 .04/ 36 mLLtipuolu L M P hb. 1964. ,cer@X. 2?? h.z,m.2.

n ~ WQ 16. L MP 2/25/6. 124 mu pig. Oprxs 38? mm.1,e.1. 7 left xx’. 73 157 28 M 16a “63 p groin Kd9,.

?4 ~ac ago L2. Iat.cemicsl LMPw. 196: leo .W6J ears. Ant. and 26 ? FUS.6,UXW.6. ; M.L ’63 oat. eroaiozm. IActat*. Otow I 75 BioF@YOCUr 122 9J/6a left rmck. ?:3. 22 F U5 ’63 wee icrwm.=. x ht.:m. 83

XLaoD 2AXMm, Urim, Pa?., mtm’zxt nIscxuu22ms, Won’2x N2UWX2EICAL,l’U2CXS,XT2. nc mm PUT x-ra7,● ce. uzxnmmmas

P@hOscolioais , Oa’tw- – artbrlt 11, mbcutuna19 Ziod of old ago 1963. b as buth hips, char?. left 5,W 2M lmct X ray neg. ’61, ’63 Ytha &fomtim a’nlbbh t-, -t2ng lonr :Oncanmg death. e*~t ie~ 1963. %2r&l%12LEw’%. H2.IIS arteriosclerosis. 6,7w 40 295 -p:Cluntamof fi~t Suspiciw @ndular ctia, both eadcactrial lad 05docemcd in ● t=kgmwd of ribl’mstod blooi. mp: NSX=ti= f= ~t UU. 3cu2ty — *X fdrly lW J,ac 37 375 mtr.agmic 1-1 (consommt with %Istory of w - 2 m ago).

mp : P2.aqU9*of sq— Med. artcr:omlerocia, 9,acc 35 250 Epithclium shw-lnx -kd aty’pia. slight kyphcsis ugh estrO@nic leml for a.ga.

mp:.xalzBtiveformliauultC&. vnccilntlml I-t. a g,ccl El@●*trc69niclevel.~ Wcciraticm. r*brlJ.e. rm. 100. 2“ mm a mlstinLyClun bukxxcud.

*P: M@ im for ~t *U. 6,2cK 250 ~CiOII withmild ~- tory awpia.

— Bp: .X8g8ci-mfor NAligMnt C41h . 7,1!X 38 295 tikcd ~ t.ionvith in- ~tory stypia.P’mdlblc.ad.

— C&#t x-my: ktad Znal.sax.; cOIKal. but(?); rt.spical h lt. a,ca Ila mlbc.lmlmllu du19iti*aof Qlfl. Lutum (~? ) ’63. -P: Ee@tln for ~t Cti.

a,zfx 42

un8ucc*MfUl aurguyrt. cy9 1963. mdarwte a.rt9rio8clu0ais 5.9a !4? Zlo &-?mric,cl*rmis. be — TAkctlfor gal. — — mud.Y. P.B. I. 8.7 ’63. ma: titll’o for m.limnut -. 5,221 26 320

chest X-rW q. ’63. F8p: *tire for Emiamnt calls. 9,m ~t 1oo. Wked krntinl.zaUa Or 6~ cd..h With at~i~. T m~ Vag.lndis UYrematia

8,30 3X Cw8kfmd mm9im. BOn. mrmvtakaforgen. ntudy.

-p: Xw3BtlvwformJlgQuIt Ceus. 9,@ kkdOrat* ●9trc+wic l-i. ~ ham ● clam W@cund.

14,4C

. 84

WIG211 em m., Pm EOODPU&82 Mnam mm MJx, 2U Imna? mw222s ~ mA2T k LIJms mer Ou or Gpa 221N —

u+5i 50 76 lks canii~y m ‘63 Cr. IV d-. M. 21M 120/70 ‘63

7 URI. Ptwilm loft Zc- of ~’a dlnua I_Lo/m em ’63, --’S 36n disuse.

~ O@ 13. 70 m 3/7@b. 146 LLo/70 &cu9 2+, * mnws , no mpm- M. 5,grw. b. pt*rjgiuD &tic - of MCk d 47 ? min ill Joints. trmk.

M-l.-‘~ 79 scar.Rt.sm. 133 130/00 Arcua 2+. and m.. - tcu WM Bi.1.at. ~. scar Wk 1 ear frm “’Euta P~ . Arcus 2+. Rt. L12° diam. 9) 126 P~s ~ it mixed lesions = 1s?. I.Ort ta 135 ’62 1.29/.90 pt8ry2ium, m. PrMtet@ 1+. fr.mt 02’Cbst , %!4 &folaDd 1*3. u?9 863 &tluymtOl*s Cwamct, 1.9rt 1. - and leg. 0p4city. (FQn.sW ).

81 Wlurchc am 15. Mole L&t W *. 1964 99 M2trmz Wmtol.ic Rt. *- bmsst . 18 F ml,grw.1. K tblckamd. vaccl.mtlm ti170 Scu l-t. arm

Arcll# k. 82 211At Ptemi= , old mld 132 u.2/6kY choroldal atrO# w, Rc-mtate mu ~ymti ’63. US ’63 l.?aticuAr erAarg9d ‘63. Oweitia*.

923 Rt. ptaqgllm. URI 139 115/60 ~~. 20 M Iy ’63

825 Liver edge dam u ’62 82/50 ‘62 1 cm ’63. 21M U3 ’63 US@ ’53 cervical e=o~i=T ’63.

a26 m27&T da N* “ El,d.i.ng m. Lat. Cuvlcu Patchy 27? -6,-.5. t-. aepLgwltat 1C2

m ccRned s-. -1s0 scar 127 Uwa ‘mrmt over pubis. all ~.

’926 mu=hu. u8 A15/To -t an

mlmrehowlz . 029 W w. ’63. Lu lm/68 ‘mrcat w?,gmv.6. U+I ’63 *r, cervical 23 F hcatlfu. Z.acamtlMU.

830 151 U%/@ 25 M

831 Atd. % 132 210/60 Rt. t0n911 24 n ~. 85

SLom - IAs Mm, QrlM, Pap.. ~b Plwm.umals, NsulOuCIaL, nnus, sm. m lla FIX x-ray, ●tc. ~Txas

8,0C0 49 35s w x.mT W. ‘62. q63 .a8iImt10n. wins pmt. KU m. ’62. m ‘a ~tim.

I II { 8,$0 35 3.15

Paw [email protected] nadu. 8,aoo u 333 FN ndu rlsbt&. -H-23,9 u 4s8

10,9JO * 315

5*7cm ~5 *

i 86

uIIGH’2 ?mnm m., Pm EmD ?mswu Iunmz ~ AX, 2a UK-T mma Izs m~ mA2T 6 LuYc$ Sm? CIAor Gym sKm — — 140auchaae9 13. 5 CM-S LLQ. 832 IMPJan. 863. (Prembly m8ri&!1 m.6,a2w.6. 101 W/Q cy8th left 26 P mat lug. ~).

333 Q@azim laft 31M URI 135 lc4/m lanr lid.

834 2X3 us/6a ’63 mim *. Xl14 Om.

Manu@ie W 12. 835 m k. ’53. Uterus L f ingere Phra.7, grav.7. 96 lcqm above pubis. 30 ? Uctst ma sinc* !ay 1%2

336 126 coma scar Z-t. WIgbt LXs. 122 ’63 125/?0 ep. Rd* l~rt 3114 neck. I

838 M ’63 N+@ ‘63 31N

I w I 156 Kq50 mat . ptezygium. *M I

uterus * cm W ~= ~.” “ nbavs pubis, m.?,gmv. r. 136 u2/lo WO.lutiolul. Rt.i 9F kctitlng *inc@ I~U~*tiCti , m b, 1*.

%2 ~. *. littlt !401eleft au snd laft tsdex 154 =2/70 bilat. tit cbeek. fi.ng9m . in~

343 mmrc2u&g013 . 1 cm. ant. I w sG@.’63. 128-1I z 96/60 >* P~ cc=ic~ i SC~ ‘*k s:’ 35 F Ears.6,~.6. erosion. ‘JteU ! neck, let% 6 =-~. at [email protected]. i :Ibav.

I w ~ml 3. W Fab.lS,’6& lca Rt. ptermium, Limr * *P. : 1 :m. mole 145? R2s. z.z,gzw. u . w ’62 Llo/m lart pinguOculM IFB :*1Y ‘breast. uRI :03 ’53

I e45 1+ H. Rt. 154 uo/70 P-~* *M MO q61 l.art Ptu-ygiua.

1+ &cu#, 9i.1.at. 8k9 Zle pterggilm , ~>=r~ on ~eq~, skin itch. m~ ’62 L&IO retilu.1 &5 M obcm. 213 ’63 arter:occler- is I ( 9% ~,,= ,,ght 14@ove Jan. 963. 167 13oj& k.+*. 55 F Fars.Li I,&l-av.lo. 166’63 B-t . pterygium. lm . URI I I

372 !.Ymopuse-20 yrs $+ &cul . ago. ?e.l-n.o, * 12b/Tc Bilst . - tag. I ::; :;;=:::. 50F ~v. o. pterygium. ~ ::{L. :~s . . “ VRI _,*:rd %r,, I

BEST AVAWM3LE COPY’ SwoD mnlm IAs Mm, or-a. PW. , m,mzib !IIsXULMXOM, N2DXU.CCI=, TJSUS, m. ~ Ecx PY.AT x-ra~,●te. sxamntrurras I I I — 1 I I I Fmp: segatlw far lMd.smat c~Ll*. ~ort 5tb fiusu both 7*W 33 35a very bi@ estrcqmie . K9Xwtlnira- S8c. ~ ma.rlan C*. k4ad4. tlm of a~ cello.

~ Ldt U.bu atyloid. -cd acne on 6,5CJJ L7 L28 w.

Cbst X--Y nas. ’63. ,63 e~cion. m ‘Q ~tion.

Fap: !ieg8Cimrorkhld8Mnt cd-u tuft bream 1 x krger. lo,3ca 3? 340 Trich-nu Vwtiis infectstion 3 MOS.D~. With Sovm-a ~tim & hlaticxytic resctlcfl.

9)&m 51 224 ChOtt x-ray nag. ’52. ,63 examilmtim. FiO‘G ~t ion.

I 9,700 50 II52.8

lap: nqptinrot Iulgmnt C4.ls. 6,900 3 - ~?, iontith ~tOIY 6 W. pregrmot. atypia. Vxilml - am.

*P: lrq-inf= mlignuatm-la.Iasms-*f-. LeftneckK&a. 8,SCQ u w Sm-u9 ~tiot, Vith mild s6pmtCmgaly. edolxmca -u stypis.V%- Rec. hy8t9r8ctMY; enlu@d - la scanty. ut9rus .

FW: !&sativafor ~ligr@mt Cell.a. !42zI= arteriosclerosis N,2QJ 35 W43 I’richcaioma Vc@naLia infss-t IOU with mflmtion. Sed blcc-i cel.lt present. w211XT Pcmsm m., Pm nmcm K.oon Puwuu m, mImT mmmms cuTm2TQ2 RLMT h LOIGS =T Ou or Cpm SKm Su P–1

953 URI 155 L58J90 59 M 145 ’63 ti~in. MO/ro 163.

8% URI. U9 ltijm Rt. Catumct. Elti, MO ’63 128@ ‘63. Ldt lontimdar 65 u R2. back pin. O$9citiud i scar . 3.+ti. Bilat.1 I 92 120/74

859 Mm0Psun2c+~ lb+Arcum.Ella?,. WO. sun. 3, 134 S6/% ptu-ygium,I.Ont Nevionneckuc nF -v. 6. 137 ’63 H*rtaM in . Cu opcit lea. l-t. chest. 1.20/& ’63. {

.%3 B1.ifx2in left ●Yb. W+ Lciya w Op aimo. ?+ K u ’61 H phthisim W.Lbi.

364 cyst left Scalp .38 M URI. 155 118/m tit . pterygim verruca of node. 3 ncvi right INpmhud. .=*

e65 lhsreh, * 13. mted h— rMPm~ ’63. 97 lea/68 Bum. . p~ D. hoiti . Utertu s? m. lo, -r. 9. illvol.ut iod. “UR I.

W ~ W la. Frc..mmmmiw, rim 3/18@ U6 IhrOst ~ . 0c6r. X0 peltic ~ Xevl neck, *F an.9,env.9. 102 ’62 uo/7k -a . Chelt 9nd std. mm I.Lgwian ‘6a.

558 Poor vision 199 =0/70 1+ hcus. 41 M 182 ‘61

m !bTn

en 26M

3+ ~. B23.st. m lka/* Ptomilm. URI. u 6Jb.aspr- RJmMut1s. 6b14 w pm. 193 toasin. Vitr..au mit i ta . L4w90 ~63.

am F8puclra CYIes: 191 120/’rc R. pt*mim. and tack. 43 M L819’63 gear aMa!len.

ml 169 116/14 32n uRI.

W 122 sQ/50 ‘mrC&t ~ Appendectw 3.in scar.

130 lm/eo cornea Opm.cltr, left. 52 !4 — 1 L+Arcua. Bflst. 2C w pterygitm, rt. FrOctat* 1+. Tt PoorVialm. 152 u20/el ~lm, I.enti. AMl tags. No @u l*(ro ’63 Cl!.2.u 0ptCitle8. ) ! !?85 * d chat L39 Llo/6J ‘QmmT.~. l% 2b M pin. syctulic N

1

tiImlQla 8g9 15. &teJ# 1*. ‘%3 242PZ/LO/@$. ==Y@=, Fam L3,gr=T. u. Zaatia* 44F B m. Siaca 103 85/60 Opuit t.as. Lut -*. $0/63 ‘ 63.

uo/70, split L+ hrcu8. Iaft w first murlfi, hntiti Cwd.- bluutiomble 3W MKmpUISaa 45, 38 ;.$ ITIT ties, l-t. hept~ly. on 67 ? Fare. o,grw.o. cs~. mrat And .*. bath lW. ~. I

W MMrchmw 17. Cel-wx 0. K., I MVIC WV. ‘63 120 96[60 Bibt. pingwculu ~ thick, *F URI. uteru anteflex . + )

w MmarCkMq 13. m 2[25@. ml 100/60 Sc 2k F k-a. 3,grw. 3. \ w’ Arms k+. But. ~W In 155/0) ptem;um, Lart Ti 66M 15b ’62 uzo/@ ‘62 Cnwt . on

638 4+ hcus. Ml@. 170 U2/78 ptorygim, Lent. #.trO*ic am-v!!.. ISc 66P iT2 ’63 *itie*. I 1 I I 13+llrew ?dlat. I m &ngucc*,led mm T’him 125 160/80> QWiti*s, reti- I.ivorS@ *P. mm G* 1 qw.n d Srterlticl*-Rostate l+. racis 2+. lb+.4CCUS. W@ mwPmU %9 5L 1?0/% SIMt . ptery?iu= Alla ++s . m. 13,*V. w. 117 meluim. aui lent. ?b r mm=, ioz ’63 LWW ‘62 Opcitiec. titing. , U@o ’63

no 2+ ArcUC. Uo i10/6b 14a.an- Left 61 M iris.

I ‘w 39 W/& 29F

915 ,U RI. U9 lm/60 3+ -. 67 M ‘Mm a-. Bt.1.at. hnt Romate 1+. Ouacltl*s. BLOW ~k cams m Mm, Pa?. , lll~s, min.. 91 mlmaa[w.. nmas, m. UBc lfcr PUT X-rq, ● CC. xEm9uMTIQs

5,?C0 lb~ 2* C?lut x-ray: ? mu-e eularg. ’53. ,53 enmizmtlcm. m *6AemmJmtim.

L0,9YJ u

I.l,coo k5 203 Cardmc—. I

sat 4x98.tned #inca ’62.

Wt e~ed since ,52.

B. z 379 ’63. PIP: n~tive fm KLigmllt COJJ.s. Trichmnu Fainful right shcWAr- Va@mlia tifa-tioa with fi- RXdiabotoa. Ostimrthritil. 10,5CO 37 328 ~tim d hiaticcytic m- reaction. Rosh bleed. Ml&i

Med. artarioacl.rccis. mp : Reg8tin for mugMut cd-h. AS2D, p-a. decmwnmtion H. kyphoncolcomis. W6 ~mic W@. Unno- Zypa W. = ud workup. war .

mp: RaemtiYa formlignsntcdL8. 10,6QJ 45 613 Kud in~ticm. UaOdUAr at-g. ’63, mbd IL@iLXI? I cdl atmia. mp:3*@Ivmfor~ *W. Ft.. leg k cm. shorter than ~= ~tica vith histio- lert l*g. &-thritia rt. m Cyt.ic raactian. R0b8bl* mcho- Rt. #lip@ fmn.1 epi@lyla kme. - [email protected] infestation.

3k0 Pac.-at8ract~. I I I -Q : Na@cim for mllgmnt CdJ9. 6,5ca 41 263 Rwk blind. Wild in~tim. Obese. ~ am s~t *. -i-- 1 I I Mc!d.Uterloaclumis. + RmbuK. ‘W I% bic~. 5,4Cm @ 2&3 A99D. Fuplla react to light. PhraMis rightem. Wpuytren’1 cmt~. + RCnhrg - huec?

WI. u*ri’mctiia. 6,100 41 Q-phomaliosic. I

Few mck and gala naks. Arteri0*c19rfmfi. Min. mteriosclarosia. h hatolc@@ enm ‘63 or i.p. pulso wax m rst. ‘6k.

7,9 37 268 ,63 e~tion. NO *6A axamnatlcn.

-1-9,kO0 37 w ?rc.statichywrtroriw. 92

mna? m., ?= ?msoxz Pm is220a’2 E400 AmQm! ii, = lsIa2Q’2 mJm12J emr!ns imKT62.olca mm hot- sKm

916 ~ a@ N. mrua to mMl.i- m OX. ’63. lk3 50/62 c-u. Fmul homrt UOF 9 m. pragnult. Wundl . FUS.UWZW. 8. A~q 917 AM. *. #car. l/Yu#2# w 1$$ 120170 BiMt.ping—cub1. b5 )S 1T5’63 * n, q.

b Arcu#. BLIAt. 918 Ptmim, lent. OLaaOtn. lea 120/7D 0pelti9*. Iatt Vurlcccela . GM W. 162 ’63 Grt& 1 cym- ~ of t01.icN. -th.

920 32 M

922 Mawcb ~ 14. w 21516k. 107 2.30/83 I:h-:?a , . m hrt face. ho? Mu,gm..u. ~, f-

928 ~ * 4?. y Arcu. Bllat. FarLl,e.1. 124 lJo/P pt417@lm, SCUY *US k?t 31T -in-d d timi-wt ,s. 5mut. Joint...

929 ~* w ~. Rt . pt8mim a ao,~v.o. LB9 uo17h ’63 hit.cities . Atru#ic cc-. 66? M %-lsion 14ft Catuwm.

932 ~ ~ N. 1X2 CM. Scnr right ~ J-. 16b. lCJI W5b cerrlcti ermicm . chest. 29F -. 3,-T. 3. v2t I

99 ~ w 13. lbl 210/’ro i% pelvic e-, I IMP 3/0/64. M ’63 mnsen . 29P mlm. o,~v. o.

935 uo/64 ? Warged liver. C611

936 ~-~ lb+Arcus. Blbt LivQr #p. m w. ago? ma=.3 , J.18 uo/6Q , no m. ChOriamtiaitti C4r?ld ‘art len nr gmv. 3. Mmtd 162.Ucu’1 and lam. ‘21rau@. eyelid.. *it iem.

938 ~ G@ lh. m ~. 163. 92 95/w ?2M utams co 27 r b~; Vgvg. rhachi L@rt umbilicus. lung.

k+ m. Oilat. I 91 ~bsQ53 . 1C9 120/7’0 pinguacti. Su’m. u,glw. m. u+o/w ‘61 r.mkoplti of Liver edge 63 T m/?2 ’63 hard sdAt*.itt.*P. m. I Cstarl.ct. I

942 Hns %.13” 134 xlo/’m 1+ &-cU,. Sc&rief% 49 r ml% O,grw.o. B2Mt. pJ. [email protected].

943

*M 93

22409 I casmm6 Ca21n LAl Mm, Urim. F*. , MIs~S, NXUX2mGrW.,Tmux, Xm. Ulc xx PL4T X-rv, ●tc. BxmIQrMTras

mp: ‘T9@tim fw #UJ.QwttC6U.S. U,2C9 38 &65 WMMW9 e8tr0g9nicleml.. 5 -. ~t. -&s?y 1’. [email protected]. T —

5,yx 103 aut x-my: flald. enlug. ’53. Gdliug might. m btologicti exm ‘64.

—

VulcO.Q win r2@t L-. 7,2m 4? 205

T—

I J- I 6,1al 36

1 I mp : -t iv- formui@ult C*U . 6,rc0 35 ~tlcm. ULd endocelw-lcal cell at~ia. V- - 1- Bcenty. ,

-P : bti- fox mll.glnnt @Lls. mi. Utarl’.mcbromia 6,4cQ bl ~t 100 vlth bi~tlOC@lC Arterlmclercaim ~lOIL Pr9ah blood. At~ic& Atrc@blc C-. --1-- &bndulu Cmlls natcd. I B. SUSU 79 ’63. WC&ri@t neck. 12,924J 33 525 Fap: mcivw fm mllgMat cO1l.4. =etlca. *8b blind. .Mild I ●ndocemlml :eU at~ia. —

9,CC0 ho 393

- I 5,1aJ L7 32b ’63 eraimtion. No ’54 axamlnation. I *: U3h cmrasaic W+’eI forW* tikd ~cion withhistio- 8,%X 37 275 mtlc ructioa. W T.SrPatmical Gu8stionmble %inal blmd.2r@. giul&lu C*US prumll% isVi&a m dinbetas.- - rustingqtuctioll of mfiO-

PBX5.6 ‘6k m: mtiw for !uA@ultCoUs. W?9r0 ~. 6 tcea rigttt fret. m tlm With histiccytlc remctial. ~ ~. ~t.. &typi@ s~ cd-lanotd &c, u-cmh Vit. c. pmlmbly ~r-ld. — I *P: r&g8tiw formMgtnnt Ceti. teukopl.uia. M~ artariomleroaim 6,5ccr 40 235 U13d irulmtiorbRdativaly Heptdy. Wh W2-lC level for W* uvi &-rari0aclerc4ts. lmostmma Mstm. Rec. *. cataract I-Omml. — W X-my neg. ‘63. hflcimt eyobmvs. *P: mtlm ror mligmant mUs. Ab8,nt kaw r&l.u8s. 6,m ha 390 ~t lan vith ~t=y< atypia. Hi@ e9trcg8nic leml for 49.

I XOt exaaimd SUIC* ’62. 94

US2CRT Pamns m., ?AS7 =EET SLcQoPS.MSU22 ~ U–E,Su RI~Y (lzmIzs mlmtnns S2AST k LLncs 2msT al or cm Sxm T1

w 162 .W1.smamleft 176 ’62 13Q@ =11. Rt. plrl- ,Xevi on a-n. 39M I 11?9 ‘63 1 gwcu.lAs, i-t. 1 I pm’gilm L I I I I I *5 bfmrcha alga 13. w 3/1/64. @a lw@2 no a. Rax-n@m, L9zt scar icraum 39 F mrwl,w.1. ?— ’63 lent.Cpcitiu. lert Mad. JRI. i 1 $+ kscu#. Bilst. %? 193/100 , SIWh pt~iu, l-t. W.fUgw2 prrmtat 3 RI. Uo 1 1P. n. esotrupia, rt. ’53, not signl- Xeti on back. 56 u uIO/$6 ‘63. cat-t , lt. ?lcant 05L. SC= ieft =. aypm-tul*lvu. lent. quitios. ! ! w “k56 M

9* 55 F

957 hkOpmMO w. U B12.at. Pt*rml!m Fu8.2,,glW.l. 16A 116/8J left lent. 56 ? Cbso. 162 ’63 Opacltiea. ml-m r t infl-. I

958 32 M I

961 h+ &-cw . Bllat . Gal. p-. 139 130/70 pterygim, left FrOstaca 1+ nkf mm ● oru 144 ‘53 lent. opacities. 1 I , ( 1- I 963 Abd.mill. 138 Ml@ I Btit.,t*rxs,m’ 46U WOms I i I I I 1 I I I I \ 1 160/90 pulse% ~ -. W *. 135 =-. -’mm c*u- Rmtate 2+ MM Sypsnmclva tmcts d lent, * Ml%) ’63 opcitles. %s ~ U* 15. I w 3j20@. Ilz Ms. llo ‘xlwnt No plvic zQF Pu%o,grw. o. emm --l

9% 148 Llo/70 Bi.lat . 32 M ?--- } , 957 k 149 ma/m ZIM

93 URI. U6 uo/66 Row riyatas- Cm. &ada 1 sw. t4. mm. Rt. @& tin rented nurl. Yevl :n :r-r~ ‘mr’cat 95

1 I I I 2LOOD ~la h mann LAJ MrA, u-m, PSP., nIsrsLIAn2ai3, 122mc4.GtaL, ItQQa, m. ~ wr fur x-rx~, ●tc. ~Tuas 6,2w 45 93 m 2.0 ‘6A. r-tm. Pap: .mr@tiTe:0? m.1-xnmt Cdl. ‘r,m 6 ~?e hhrkod ~tiom mgmemtlng gmaddar mu- seal. K142h estrcgmic 1oI-.1 noted. I I

(hut x-my: Kin. SUFi. enlarg. , mal.uata + m hypca-tmsim. 36Y aortic u-teriwcieroais ‘63. R8c. Cstaractraova! 1 I I I Oselucas . 2’98 RostatichyprtrOJ&?. rPOsn-takmformn.sti I.

Pap: Na@tiv’efor luiezuat Caus. ~ U-tAriomlcrais. 8,.$20 3 350 ROlsti=ly law estxxumic bnl w. gJu89s. noted. W or #o giant cti S*.

chart x-my: ?mnslty .*. !lilUm 358 tiWIIAU.;c~, ~tiuctncy , 863 examimtinn. No ’64 OnmJlmtian. 1

253 R’vstatlc hypermophy. I I

lp~-=t:m, no il-tda6Y. I ! ~tlon. ! I i afimchmsis and hYW*ensi . PrOrtstic h,vPutrOPhY. 203 2cyFdlmc01i0sia. WC. ca~ ~? [ rI I

0,i3x n w

8,4X 47 2’FJ I

8,3c0 52 96

m., Pm Ms. 2X mm? — —

9m ~woh mm. o,~. o. 50 F

Yfl la Llo/70 an Ldt pt~m Scu rt. mauld,r.

2+ *. M. 973 Lmilu U91ght. 55 n

Ym Q m

I %2 Mmsrdm ago 14, UP, Pr8soot . &3p la leo/u5 mm. 3,-.2. MO ’62 Am. ~. / --1OLL ~lm, btit .w. , no . w left 170/106 162. ● 1 Palvic Rz houda.. * 32?

I I I 391 ~w05k mr=.1,gmr.1. %r mmn. Lutut*, .

mm ~ ~ 13. -1-= Lb@12/15/63. Wr h. 7,-v. 6. -1-L 1CQ5 I lyylo Qll 1 -EclL- I I I lW Absent lat. z, 53 M 155

lobl chat* 3.84 863 59n UIII lzoplti Rt. ptuyg’im mu ldt 1 4 i 1 mmrcb9 ~ 17. ma m *. ’64. 1.20 -n.6,gnv. b. 133 ,63 h* Wd@it.

lo&3 ~ w lk. % ~m 3/5@$. 105/60 1+ .4rMls. Bilat. B? Pmi=. I I I 10’N MWUCIUus 18. IA@2/15/6L 138 120/78 mulio’c Syn. w? -.1,-.1. SCU right AM. pBin. . &a. mrmt biceps. ~. 1 I ! — 15C0 u? 120/70 ‘x7211Xt~ 33 M IC8 ,63 Xevi ri~ht shoulder. 97

mMD mnm u Mm, Url.m, P8P. , ~& KIw%2JAuxa2s. NBmx,a[cu., Imu2, X’rc. Ulc mm PIAr x-cay,●CC. ~TIas I I lFwl: Ihcati’m far ~t cu. I { -tia fith S--~ Qrzcwctiia. I@ cdl atypia. 3ccu81d Muclmtd PAhm la 1U4. Cq— mu Ilotd. Gcd MC. Cha8t X-mr d @n#es . ●*x’0E9niclml. 1 \ r C2m8tx-mm Plu2mlthickullr4 Lt. ~~X; iJIC~ bronchmmsc. W3 -mgs fra It. hilul tito Sp (’mm) 463.

k15 Isles Cimst.

I 1

! , I 283 PBI 6.3 ‘G. Q*. Eypmtaui.a

no ~tian since ’61.

i F2. sz60mg$*6b. pap: U9@lva ror~ CauJ. Arteriwclercda. mdml artui0mlumi9. 13*WO k7 323 Mc&ntdy M@ estrogmic l-~ Catarsct . for &ga. ~ tmva a rd8tlvQ2.YM dlabotas . \ cl- ~. I Pap:Na@timrw Iu4wt Ceu.8. 1 x1.5 cm. mss dursua >,EZO 3g 2eo ~tim W2th histicwtlc --t . right wrist . r9act ion. ~. ~ @b21im I-t. u-rise

Umf 332 P B 17.9 ‘@+. Arthritis or -t

Pr08t4tic hmwuvPbY. *2 tia’8 die- quuticmd. -_tir=w.w r.

w B. 9u@r U% ’63. -Op. iIlf*Cti~ PX’5.

—

3?0

P3 I 5.8 ‘ah. 324 Rp: Smptim for ml.@8m. C42M . mild~t.lon. IH.e21am=m~c 1*. Culicsl - is Kulty.

5,20J 51 2?5 98

Vtxcm PAsr Panm E@oo ?Uamu m., Uxrcm Amam *X, Su Els?al mm m ~ MT 6 W2c$ mm * or Gp SKIM

Lml URI. 147 lcqa AU. ~. 27 x

lwi! MnUCha * 13. ‘walls yn MIX MP J%.IY’63. 12k 100/60 *t ti~ , xlxoid. urrial 25 F Pare. 5,gmv.3. ercaim. ‘7-.~.

— 99

mom mmfn W MTA, Urtia, PaP., ~T3 6 UISCZI.UNXmS, ncImUJX1C4.L,ra)ns, Em. WC am PXAT x-ray,●tc. ~TrrDs

cheatx-my! m. en2Arg., 3,7W u 258 miniy It. ’63.

Chest X-my n%. ’63. -p: .~tiw for Mbllgnant tells. T_richmonu 12,&c 32 216 Wi.nai:n mfe9tat:0n with sown Prqnant, 7 a, !nrlWt Ic?l, with ~tory ,ntypia & hi8ticcyt:c reaction. 100 .4PPHmx 8

BEST AVAILABLE COPY Indtti&aL Children Physical Findt~s 101

f B2am u Mm, Wrl.m, P-. . anmT2 & lmcmumma, calm NEo2rxm[uL, maR2, 2TC. W em P2AT x-ray,●m. ~mns

— m - ’51 7,65o p 1139 ml; ;;?,6Z

%ad 51.5 cm; odd appu- ?mIM6. ’57 cad pbysicd ●ppouance - mce to f=.; Sm=f. 12,02s 36 3% Eai ‘5’7 7 cretmoid; hww VOiC~ Stitur, inert ox ’62

1

W statura - stubby Prminent Mrtlc nrch m ‘% x-l-aII fhgarS 6,250 37 365 wor~ d,foti bilmt. ,62; PPDnag. ’57; 933 ’51

PPDmig. ’57 7,550 37 328 BCG‘?’r ckt ox ’62 PBI 7.9 (’63)

u, m> 40 k% PPDWa. ’57 m ’57

7,75O* 332 PP21nag. ’57 m ’57 mast OK’62

WOW& ’57 6,35039 m m ’57 m~~t ox ‘62 PBI 6.8 ‘6k

PPD*. ’57 $,675k0 * Kn ’57 &e#t OX ’62

Mm(?) 7,& 550 26s mm ox ’62

??0 .m. ‘57 ‘f,cm ~2275 m ’57 Qm8?.OX’62 ?22 8.1 (’6A)

mma. ’57 7,’a 39 365 Em ’57 .52ms2ox ’62

9,1m 39X6 m-~ti ~ :~:

8,625 u 585 PPnnw. ‘5? mast OX ’62

Mclduoua Umu tied PPo neg. ‘5? incisor Fa19ists q,m gula am “57 C!lOmox ’52

7.65 36 y% (61 mum.) W emunad since ’41 102

IimxiT m., mm Poo2m8 I12mat M.oOD?2222UU A2DmmI us, m mm? mm 222 c22P12n221m2IUAlr 6 WIGS m ‘Guorcy?l S?ml — @ No caplAint, lo3-3/& 138/78 ’64 155.0 Gr I s~alic Q Twth finQ L.iwm at. cortai FZLZ.Nteh r?. L6 F ’62; non 86k mrgb neck

AM. patidwly; 53 ~; h-- ml.3/k 126/70 CO= T-Lnea titis (data?); L55.O opmitiem 18 ? lump- in at40. (POstezior ) w ‘a date ? 1

* Wttled pig. k M eig.k ,64 a-3/b LIo/62 depig. aeck UK 14.0.2 Gr I systolic m ,bfip,y45um

65 Vmcubr emmml.y‘Idver 2 cm down Yeck SC-S MiJ.duRI ‘6k 52.0 9v5J4 uppar uargin !lOted LIF 123.7 Gr I swtollc M Or aim 09 ,62; no a ’64

69 URI’l; Occ. abd. 108/?2 WQ ’58; mm; 101 Gr I systelic a a ncdule b / !Ieg. lk ? n8s. ‘6A 155.k ’63; no * ,6A; no 1. th~id Cudimagnly I

72 OK ‘a 136.1/2 130/68 17 F :57.2 GrIntiprd AM- OK Acne an face w

83 sb-1/l! Kx3/-p4 Rt. m md; m h. ‘6A 113.3 dentsl :82iea.5; Wg 10 ~ Cerficti nodm

& no Slg. iu. ‘6A 57-1/2 82/6a OK Scara 10 !4 L2k.O I I I 85 u Assm. skull; ‘et *O lm. 9 rhinitis ~face 57 9M /-; ‘“

aplllaan :. Z4 u 95/50(’62) C825ea; thlnt ; 201C Otitls IJ6. 3 Gr I sw a ’62, gmu’u+zed I ?ace; noLAs 9P ’59; no n ‘% ntis ’62 i’:? I I 87 macap.laints 4.3 ?8/58 ORl 9? IL8. 3 GrIaymm

88 52-112 82/6a %Iw akdcmm; , *a.rn 9!4 s8.0 Gr Isyam diarrhea

@ 45-1/2 92/68 CMbilatt- Tsmaa SOWI scar r.. m ●lg. bx. ’64 U5.2 GrIawa ixilla 9U [ ( 1

w 5@. Wits jib nO— FW bilSt. Flgaon bresst blccdy 120.0 heard ,6k cwv. ncdes ’62; liver 5 cm t. 9n diarrh8s ‘57 ,9

I 91 I X0 S*. &. ‘& 55-L/2 lw/7k ORI; rhi.norrhea I L21b.1 9M GrIsm~ ) —. — BEST AVAHJU3LE COPY 103

1 I I I M.2on Cfmma IA2 Mm, Ur2ne, ?*., C902RT26 !!Isa2.w12ma, -IZIXILXL, 7UIU8, 27X. U8c Em PLAI X-rw, *tc. 2xcmuxurxQa I

T,K5 u 29s maat ox ’62 m ms. ‘5T m ’57

6,300 w 53 crest os ‘62

Leaioa on tack avstics ?, 350 57 36a w ox ’62 a simple p~td - II

GUOstia of Sturga *bar 7, m 38 378 ~n%m, ;3 timed ‘58

6,@I U q mu L2.2 163 ?Fll*. ‘% PSI 10.2 (’6A)

*US Or ~tqO 8,@J 36$2 C21ertox ’62

\ \

9,xw y7 350 most ox r62 Pm nq. *T

3,4G0 @ 424 ?21 9.3 (’@)

7,287 40 277 Pm ~. f57 ~ ’63 m ’57 ,s0 - ’64

Csre au tit spot 7,328 39 2wl mm ox ’62 ~ ‘6 S“mn m X. ’57 m-’ J BYi ‘5?

WW * m m os ’63

MSOO 36 355 a-t ox’63

1.0,900 w 395 PPDmg. ’57 m ’57

I.l, xo 3? m w 02’63 m nag. ‘ 57 m ’57

9,a50 * 298 Cbmt OX’63 = mg. ‘ 57 m ‘5-I 104 105

mmm ca9fET26 mmn US Mm, mm, Pap. , mma%%%%%a.2d. UB2 EC2 PUT r-ray, ●CC. ~rIa8 !

9,1C0 U 52+2 PPDnag. ’57 m ’57

13,cul 37 503 cht m ’62

U,* B 675

chest ox ,62 afitO* lcuor ax-tr. lZ, W 3? klb PPOnea’57 ~ 163; mwia (polio) m ’57 no ~tim ‘64 mtd mid *mia of left ieg vitb●txuph.y 15,2W 36 619 Rec.kmliomtmbtlitatim at Or glutti M 6 tip or Wum 1 m h+ (k7.2 cm); 8,5W 37 678 tit ccciQut L

Veq al. 1- rt. &al Ll,m 36 528 2pi*ysti [email protected] m x-my *. h @ Vlt. c X-IS persists of Cbm (h- )

6,6w 35 633

ll,lm 36 623

8,&T0 @ &a Yx tcnsutis; rsc. arn for ~ tion

no mm Wsklm,a ?- LO*WJ s 503

12,600 39 W maot X-W 0s ’63

u,650 37 h33

VQryquest Imablc rt . 10,600 37 41? lower facial ~sis

13,200 36 WO 106 107

I I 1 f

klo

7 ‘m38

6,350 35 635 i

64?

WI

I I

95 I ‘“’ml ‘

63I

Ll,&Q ‘g 589 I

ml I

b17

53-I

13,6cQ ‘4 328

U.9CQ 9 Ma 1963 ~tinn; no e~tim ‘6A

1 520 I 108

UEICllT m., PAST ?mnm S!22CIIT M.cODPmsaotx Amm2m Ux, m F2191QT KNJPJU2SS cnrr~ UT h -~ m ‘a or Gpn SKIN

i26 ? %Uo 2L1/b 214 TIP of Splmcl 9.1.o only

127 Gr I sywcol,.ic :POllo; 21-1/L 2P no & ,64 M ’63; WIm Madibla ●t this w navul t- (la) 1. cheek

128 cOnswitti h~lca L6-3/k -1- ,1 F =. Mklm; M neck d tu. ’64 back

ly lU m m

W lM 13 m m

i32 lM 13.1/lb 9Om

134 lF lr-jjlb MOm

135 2F no m

801 ccc . abd. ~ja; M/& an 39.0 s~olic ~ ,62; lbd 49 a Liver nor, m t-i ml iod. k no m 864 “* .s on * mble W d and :e<

?02 URI; abscmma an 48.0 S- ouc ~ ,62; ~& Ca Wk ‘% l-la. 1 !10SC:I,re m m la am. Col-r. nc.ie, ~ =pe.ig.

%3 ml ; a. 8M 4 Sym,Oz,ic m ,63; Had 51.1 cm SOth t*at*s * Occ. U8. 1 scars Cf no m ’64 deceti ClOu -et qo

&J5 Cudd& ~. 9a@3 61 Gr I sm ~ ,638 -m CJyOpia ‘57; $uRnt 129.9 “-.3 On :.*: 10 F no m ,6h,ll— bu T.*rally fsor. ‘sole ; ductus; URI P2 1● mrylGud 1, % 47.5 9M Gr I s~ x $61 anru.u ; .,evts.. :. .-A.. u.8 .3 & ~tby I lo2/6k we #and 927 kl-1/4 2J0s ig. b. ,U Gr I Systolic m Pm hem; $Ub- 10 M U6 .? ’62; LUIUI,64 !mndibuLar mde *- C4ries j , had 48.7 a — w At4. p2n ,59; 49 3F r~~ ~ ~; m~. ~er 1. j cm Iwo Ims 11?. 3 nOie*;

am 35 I

no Wpr9?It m8cL9 13*W 32 %5 W. m and v;t. c wuknem I

la.’rca 33 3P

8,75o 37 4a5

13,950 35 6T0

9,cc+3 28 kn I Me.irmadvit. c

n9 k. irm and Vlt. c

628 W. irm aui Vit. c

8,em 40

10,’752 W 265 mastOK’62 m- ’51

U,xo 39

ll,w U ----rL 13,6CU I 36

520 cmti m ’62 1%3 e~tion! w e~tion ‘6b 110

UEIGET Pm Pm m P-mm ~ m., P222G217 &x, SR EI~Y mmm mDm22s IQA2T h LOWS 2m2 Gil Or Gpn

w w-ilk 92/4J wstis doua scar 9U 123.9 vary ?a2.m. ●m m

-m !4u91A OD; &o 102/62 mrksd cuPQin.2 m 56.5 or I aPi& ti d.ibca bllAt. ; 9F 131.6 Spwuc m - Mrou@rt. Otit lB ruactiaml d

au 92/642 Ccc. w’s 56.1/2 Gr I wi=l CYS -~ 10? L25.o m - fuac’timml dischuga

au night bllIMimu ; Tin CanmJ.sim ’57 - 58-1/2 w3/76 TuMti 2* Lnp 9P Csusa! 129.7 GrIeysm act M

813 F&vO?m; Lml 55 lC4/T2 UFiI; t-u # I.lwr 1 m down I!q 10 M IZ5.9 P>- > A2; m rn’~ m i.MpimtlOn 1

W w ’61; nag.’ 64 69.0 92/6a .- Vru Umrladwni Ku 1*. 3 20m tortes dmm

815 ~ ixutll. mss ’63} -M. e%o lC8/52 2pw sag. + ski 13 M * ’59 (’5n) lk9, J4 Nom teeth gccd

L12/52 916 ~ndii E q63; lmuti 1+; ‘ sin I.@ am. corr. n0d99 :rA lb F 152.3 +>;2

ale L22@a mu 81-3/L Gr I rgs IE ’62; Tensll# 1+; sca 12 w 146.3 LlOm’a hut. cm. .lc& s +>P2

819 IAA ’62. CCC. lea/6% d~; OCC. 1.23 hn’@;~I ht. Cem. Md9s 15 M a. *; 16k. 5 #yam ’59 nu. ‘~

Eal - ’58; m UO170 mg. n0d9Lcn 15 x ti.1 lPOm, P2*A2 an right; ml. sc ‘N* *

w - o=. ‘5% 126-1/2 98/62 w=- lk’1.7 BOmf@; grI ~ia Sk 11 r #ti$ m. ‘& apmIrL’63

92/ko 822 RrrOntAum 169 Mruy8t01*9 ‘591 w. ~ 159.9 vith bmd~ Liver ed8m@ p. 17 H * =. ’63; M m, (* 92)

%3 126/78 ROmu. b. ‘a 85.0 klm’6A; srI A lb M lLT. o am m ’62

82/50 IYACUA m ‘s; Uwr e*e at 246 GrIIsYBm ’63; =t. CUV. l10i9*: U2PI G-l 12 @lt P~-nO mtosw mm Costd =gln 9F I.lg. 2 ~bl* SW m~ 111

mdm Ca92ETs6 ~ Us Mm. IJrh*, Pzp. , H132xuAn2ws, NxuW.mIw., IQ2sms, Xlc. U2C Em ?2Ar X-rar, ● ce. ~TIms

—8,9 35 yxl @st m ’62 Pm - ’57 m - *57

a,um B 461 @Jest ox f62 PPD. ’57 Em - ’57

ll,?w 35 433 ‘chat ox ’52

8,&a 38 333 @st ox ,63 m - ‘y? Eni - ’57

6,.55o * ko5 PPO- *77 mast x-my

Ea9d *W CRJ Siza meat m ,62 50.7= 10, W 36 287 pm - *57 m - ’51

8,1C0 38 m pm - *57 Boi - ’57

9,W 37 334 ~- :;7’62 m - ’57

9,%0 39 505 most ox ’62 mD- ‘%

5,450 * 273 cIuti ax ’62 Pm - ’57 m - ’77

23,200 u W msst ox 162 Pm - ’57 tic. ~m fm Otitla mdi a m - ’57

8,5oo 30 k25 PPD. 15? m - ’57

U+pzm a 628 Zhast OX 162

9,W @ 730 chst ox 862

5,2CQ 37 203 pm+ ,57 112

U21GSI ?ausm Eoon ?U2zou Moam Pm Emom Sscci m. , sum GUor Gyn mJmx22 m~ SSA2T 6 Lm2x *S, = Exslmf

Scmm 3-70 J6.3/k 92/66 Pal.lo Or IWSM 9U 120.9

I ~,: “’~ m L19 w3/60 . Wbawriad * 168.3 m. smn ’58 17 u ,59; Wrm

Mmkd -a @@50 on L. feat; m 51b.o Gr I hPiti Umrlcmd.mn qetigo war NC. ~; 126.3 Sys m 9F Mym m 1. foot

~irn nur m. Lmetiw w U6 lloj-ro disc - m ‘59 169 ,62 thmqht tO ~ 18 M - *-

7? 1 1 , I I 113

Q.oao ~6 ml,a Ml Mm, Orinc, P8p. , I(namxlmms, m201a&Iw,, mm2, m. w 92X HAT K-ray, ●-. 220nmmmas —

Slli#t l%. lcuor :*IU 5,- 35 k83 m - ’57 -la w m “62

! 1

13,4cQ 37 293 m + *56

8,3oo U 235

T,’?al k3 295 --d--IL

19, WO1341* Irhc. li-muldvit. c I

Il,mo m b35

14,500 3? w

7,&a * k55 I

6,m k2 325

18,5@J 36 L16 most OK ‘61 114

wmo21Y Pcasm m P2m2u22 ~ No., PA2Y munY &x, Sn R12YmY EWOBI.2S cmTn221m2 iuA2T k Lu12x 2UY m or Gym sKm — — - — P 9L2 Ant. cm7ical w ●ignMICUlt 58 %/% 3U289; ~iti UN mm ‘~ lY. 8 do not S- enlumi

913 lcq% !?4h. ‘* m Gr I 8Y8m ’62; cl- mnitdls 2 SCUa of 13 n lyl o no m, ~ Sput ~ettio in ’64

919 2WJMU6 of l-t. -St; au. rr-1/2 &/50 L624 ~ 162 150

92L m ‘a 56-1/4 u38150 TOM* * 10 n 125.0 GrIayxm I

923 m ‘61-163; 82/60 10a9 or hau5D4 J bbil~ SW m gr I ’63; CU-icw tasth Livar 2 cm ’62; -m 9? Ccwiunl no m “4 neg. ‘@ Ems euaches ‘64

924 10? cm ‘62 ?ti,celxiod - ) 9W t,fiis ‘62

925 m? ’59 m. lo2/& II 22Mp.;max. 8&34k & ~ s~b n ’62; S1. mfactio?l lb F bx. ‘6A of tbscat 1 *

926 32/6Q bllndnc 8s n.o sy9r. srI’59; i?igtit ! , ~;:,, 13 F in ’63; m ‘ a 140.6 no m ‘G I I

930 FOlio, 7Q2Am - ’59; m~ 54-1/2 70/58 & I sw @Cti 8F ieg * ‘* la. 7 m ~

I 93 */% ~ ~~ C. m ‘a 53 . Inn i22. 9

937 R UT ~ !40LLw:a ur

939 No au. h. ’64 :;:; /4 118/50 18 M !iam run scar

I

m ~- ’62; a-3/~ 90/50 atormaa ‘61 146.5 Gr I sm n ’62 c.um~ + ’62 F@ scar, cause! 15 M \

* I 31-1/2 M6/62 : Scars 13 F 147.8 — I 954 % CmvLdn Ca’a lye- 1/2 i22/82 “ma- 20F 155.k . . — 224m cauuT26 IA2 mm, ucitw PIQ. , nx~ws, Cunr12 immmcGzaL* m28s, xm. WC Ecx Puf X-rsy, ●CC. sl!~mms

2,csXl 36 215 mast ox ’63

C4micd ncdu

,o,6ca @ 423 m-t ox *62

Clcaw ad bypauml-?a -flm- ’62

6,6m a 275 ~st ox ’62J Platol*ts ( ‘59) w (’a) 453

.l, em w 360

8,6M * 651 - m ’62

L3,200 36 h65

l??~ 3-7 m Chut ox ,62

U,&lo 43 m PPD ’56, M8.

8,5c0 W 335 ch- m ’62

mwt X--Y ’62; prm. w mm 6,5w &l 75 iaf~ti-nti fi. be I I l--) I 116

W3202T P29mne no. , PAST 8XICET m ?lmm ~ *E, $u arm? mnms m~ m2Au’261Jmx roll’ al or Gym SKE+ — 952 Joint x ’61; ~3-31~ 8h/52 Cariam *US Onll/ no C@. hx. ‘6A 115.9 7M

951b m b m ’61; w 39.0 R/@ &d 1. Limr dire *P. Act:vu m? : 1? W. 3 2- ’63

955 no Su. h. ‘h 98.0 u6/8z T’aea spots 12 P 145.0

959 FM.nt.ag apati , 127.0 120/e2 edm of feet’63 ; 150.0 Gr I sya m ’62; 1+ :Cmstis 16 F m. ‘* no m ‘6&

w 124/70 No ●*. hx. ’64 i 9??l/lb Gr II-III sw m 13 ? 163, 162; no m Stxlibla ‘6k

962 WOm ’61; Joint 61-L/b %/w ~J61 ; naus- 13.1 Or I SW m ’63; UP no m ’64

m otlt2.# Md k5-1/2 &/h **S %Uuscunl : 9N std. x ’61 217.2

9’7-7 109-1/2 122/76 157.5 18 F

9’ru , m slg. hx. ‘a 101-1/2 $3/70 ~ *=-S ~- 13 F 151.3 @etigo

5-79 m ●ig. hx. ’64 u2-3/k 9P LL5.1

* ore. m82giA ~61; ? QfitS ‘59; 35.0 &/a Liver e5g0 at 2J. F no s%. m. ‘a Ilk. 3 Costd win

Kolluscm. * sc= on ~:. . ORI ’64 51-1/2 %/50 Liver 1 cm dow :rest ‘ml-- 10 M 12s.3 GrIsywm act ive tipe

98’7 * ’62 98 m ’61 Liver 2.5 cm ’61 ‘hpez:a~ TM

9B MO/@ Mol.lusc,a - Gr Isysn ’59 ;p.~g~ 19 M

992 Admttad to h*9 . with 32-1/4 Gr II SP m ’62 Liver 3 :m ‘59 hpe%,~. 6F ~ ’79 39.2

BEST AVAILABLE COPY 117

I I I 1 m Caam7sb Omns TAs Mm, Urim, -P. ! Bmscuumms, X-rq, Qce. ss2a9emnas NsilsoLcGIuL, -S* ~. ~ am PMr —

Ca”f’lcd d m2iuArY 16,400 37 61o ncd09

u,&YJ 38 328

T,&Xl 39 530 aiUC os ’62

m+ ’51 ~,lco * U.9 aIOSt ’62 mfimati m. tic; ~ ’63 neg.

9,25037 39 ~ - ’51 chsst I&S. ’62

6, m 35 365 Chnt neg. ’62

1%3 ~tian; not OnmlMd 1964 6, 874 33 w QWfi UQS. ’63

13,CCU 28 Qs , 1 J I

I ?,m 39 2L8

9,700 - *

a,lloo u 203

12,# * ~1.o M MU. ’62

Mt, enalmd SI!JC*1961

I I [ I 118

W21GET Pa2ksm m., ?Asr moon ?Bnstlm ~ FQSCIST El, 2U HImY mm 222 mITm2TnJ -T 6 -S MIT Gu or Gpm SKm

— — — — ,- . ‘~ under :. W3 w sig. b. !* 21J.3/k */& I ~le” . . ~ 17 F L54.6 mm ,62; acara ‘:-

ticoriation X. 995 lip, zul.r on ORI k2 :heak ‘63; tk. lF Llo.9 on fbca ‘64

1.C6/60 Joint * ●t NOmeXwt; grI 996 night fcu Vs. , 62i3p no hx. of furthnr a p-; a- -lms B59 tit 5eVa.1. *3 B&&m-&a Ill’ joint m ’64 ultil’d# rumc- t:ona.1

m Ulfectiow a- ~ent I titi~‘58(?>; U9. O 128[63 ppiUU an I 17 F no tu. of gig. ’64 155.? nom taq.us, &k la Calcu

lmz T~ UQ */& 9M & GrIsyra COrvicd IlOi@s ,Activ, ‘qc~.

lC#4 Joint A ’61; 36.0 no tu. Oxcqlt 104.0 Or Isyrrn Tomfls # wars threugl>- 6VM m ’64 cut

10C6 Atd. x &tcr 82/60 Uver edge ●t UP,Q2; poor 3661? Gr I sw M ’63, Costal ml’gi.u; 6!4 appt 1* 96L ’62; no m 164 1+ t0ns23J,ar m=*7

1GQ9 3?. o I 5M $9.1 GrIsmrn Uver 1 cm Cim scars

Lolo ~es; m 33# Or I SP m, Wccmti:n 4U Si.g. hx. ‘a msical LLver 1 cm scar (fres,z

1o11 NO Siglltiicant 3;;3g~ ~1’wauucz 5? k ‘a Nom

1o12 Polio (?); Ore. mk82.@a; nag. w3/k */& scars 5F ucrpt U2U‘* IJ.o. 8

IDIJJ Pa/u B-l/k GrII=@ 8M U3. 4 apicald Mitral-

1.015 29# 3M

1017 Joiut W= ‘61 28-3/L Tmgw desq-- Ubilicd 6H 95.6 ~td ‘62 titi 862

1018 Sin ,Aszrz 30;3$b sw gr I m ’62; leg ,52;s: lb!4 nom’s cc :S.gs.- .—

BEST AVAILABLE COPY 119

2LW0 @22Um& Cuar22 M2 mm, urine,Pap. , n19cmA122Ws, NEUW2.m1cx2,* ~, m. U22 RCT Pmr x-ra~, lee. ~ZII128

10,lW $0 J4A5 cbst OK‘62

8,y33 38 350 Qost ox ’63

14, yX 33 629 PPD ‘56, n~ti-m; ciwst x-ray “52 Reclmck X.ray, MC. iron hnd pra. pLL. mmlla 7it . c

10,9CKI U 326 Che W. ’62

LnguinU ncdem 1 cm lb, 5W 35 $3

!?cdOSthrc@lVLlt 12,.5C0 37 %

L6,9c0 37 553

3,XYI 7.3 2&

, Ll,500 37 613

U,ti 38 283

1,2C0 35 kla

9,600 @ 225

12,2CU Q 161 1%3 ex8miJlstla@,; not e~ ‘64

9,&Cm 33 &16 1%3 e~tion; notenminedna

12,mJ 36 6JL9 120

Um.osm Pm no. , PAS2 mm Emu ?Immu Mnam m, 2U EI-T mm K22 CmTnmuz imuT 6 Unm 2U’2 a or Gp SK121 — 1019 ~tti; Actim m 30-3/4 I.iw * mpet igo 4? 95.2 *W*

Conju?lctifitis lwo ’63; bulti Il!pmiga; Radwu Iw. ; 28-3/L :m.juQcti- Ileioid-like 5P ems ●tm rad’a *.5 .maada in.jectul lenlcm on in ’64 mck

W31 22 # ’61 IIr.pltlgo f61 5F

10ZZ 32-lJk k? 93.1

102A Olarrh@a vlth bkui 161; neg 3g-1/k Gr I am Q ’63; 5car9 4U la Lcw.o nOm’6& ..

L025 ~ -; pauoj Mg. k. 5F z:; ~Gr Im Zkinneg.

1026 %. n%. 164 29-3/& k?, %. T GrIsmn skin neg.

1.027 No Sig. b. ’64 z? Gr I s- w scars CX&f 3M 97.0 m rtit

1028 tie. diurhaa vlth bid. m 21-1/2 # 3M WI ’63

1.029 29-L/4 3? w. 5

Vltiligc-. 1o30 spots cc : 29-1/4 Lngulti 5. 3M 90.2 Gr I apical sw a 2Mltn.-.ure , hand

WJ. .!w.hs ran :.- FbL.lo; m aig. trmk; ape- 3r lu. ’64 y2-1/26 GrIs$m M on Leg-s

1032 Roe. m. ’52 L!4

—.—

1033 Llo/7a Neg. t64 1.05 Gr I sw 163,162; M M 150.0 no m *!3

10* UOm, mr p/60 &psmtit* ,53; 38-3/4 GrIswm - T0ns5Ja 1+ 5CUS 6F ORI only ‘5A U2. 5 ?2 > A2 —

BEST AVAILABLE COPY 121

maB m220T24 ~ w Mm, min., ?-., MIS~S, Nxu21%m1CAL,lu2m22, 2m. m mm PUT X-rv, ●te. mammmas 122

PAST I .uDaml HI- I tmmm mm GM or CPU SK!21

—1.035 u6m so Sig. &. ‘a 107.0 WIqwm- %2U9 15 P 146.3 Mitml ~

LU)* I I so S*. &. ’64 12 M I1

L03’7 I + 2L3/L # 3a2n@md I 2M brnia

Lo* adonly’a 2N I

1039 3Rx-dLd’a *us 2M

mm KO●ig. h.istm ’64s pauo ’63; 2a-3/k ScUs 3ss ruhosmnock 87.0 h *63

FlCQ !s0 ●sg. hx. ’64 20# skin neg. 2? I I

Llob5 I 2U

10U l?-yk # mm h nag. %In T3g . 1)4

low ma ●*. b. ‘* 18-3/b # 2pla0n 2 cm ’53 1-2M 35.0 L b)s 97.9 m m m -4-104/56 u?.6 I

I 1(252 I UnI 58 lcqn I UN I 13?.1I GrIom= I 1o53 I m ●u. h. ‘6k 33-1/2 92/ 56 5!4 99.0 GrI#rsrn ‘1bMU.1 1+ Liver 1 cm dwn I ~

1054 I kn I

BEST AVNLABLE COPY 123

2L9m CasmtTsb aws’n us m% U?im, Pap. , NIsmZ.14suIs , N20sm.mImL, lulus, S’2c. m ECI P~T x-ray, !Cc. ~rxms — 12,500 U lb33 ckt x-ray LW. ‘62

11, cca 3? 151

Fresh vaccmtiaa sx 8,025 37 681

10, ?CJ3 35 5al

14,193 u 493

9,6X 37 603

Ll,cm 29 635 k. &on * Vlt. c

L2,?w 35 545 1%3 eXU.i.mtlOa; not ~ ‘a

10,500 * 520

17>71X 35 69

U,zcm 39 w

9,&lo y5 k%

8,3C0 38 qo

13,&43 59 225 124

!JzIGnl POQ2202 Emo PIPaauu M2am Pm P2B2caT m. , 2EIT w 0? CPU SKm nl.lm 122 cumtm=s -T 6 UJlOX –ma, Su n121cm

1055

1P

10% 8.UII # 1X

105T i5 # w m LF

1058 3-1/ 2 # m. in

1503 2Qr0* on 70/58 mcazru.sj no h. p-ilk Zcu-s *.1 Gr I apical sYa 6n of Sig. ‘* a

FQ2A0(?) tit efi 15C4 25-1/k cr I apical mYs no slg. htit my ZIP Mid,mm las 85.2 m pm ‘a

—

— 125

I I WOOD msmm k CmnTs M Mm, urine, P*. , nIsal.ulPSaJs. X-rq, ●ce. maSSmmATxas Kslma.fx IuL, I’tnmS, STc. ~ Em PLAT

— I I

~ca- m cm nlQk* ls,al 35 536 ingw to r:ce a Juguaa

a,ism 37 5Y

3,58a 39 251

NOevidence of pueais; renexaa !lA

I Mmmn 9 MTm@@mMc szwYoFMXJL!rMmSMmBE — Al- R. 2ehnbe, Jr., lLD.

Unix Principle ~er4in2 ~c WmeuZ=Snta.

.— F, R factor derived _ ~w/h0”7 ispropoz%iondto thereof llc~ femace~ sad the - of the U clrc@erence8 divided by F 1S ● biologic c~ Y mweW 195 (1* to 197) for tide4 differing groupe of m81es. If the me8n value for each ~ti 18 dltided by F, then the qwtle!xt

(kksan/F or d) C- be usedfor compuison of meumwnenta. lhe d VeUaea are the = ~nt s convex+asdto e c~ bets for c~son of rehtive body size.

Analysis of Data.

~FmALm laMvALuEs* GrouP1 N- 10 GroupU 1!=10 Reference- m 30.3 n. mflBia’n. 20 to 24 yr. Weight52.4 kg. 56.8 kg. Eeight 15.10 & Gl &: 16.3a dm P = 2.797 F . 2.793 F. 2.832

Cizmsnference cm d vdn.es d Values cm d Velues ca/F) m (cm/F) (=/F)

Shoulder 94.08 33.63 94.45 33.82 W. 16 34.30 Biceps 26.44 I.o.l’r 28.53 10.22 25.90 9.% Forem 23.95 8.56 23.14 8.= 24.28 8.57 wet 14.76 5.28 14.65 5.25 15.31 5.40 -m:fi - - - 81.79 29.24 81.o2 29.co 83.1? 29.39 wet (Abd.1) (p$(g.f:) (7#3#2J.8# (66.33)(23.42) ADd. avg. 72.33 25.53 Butt- 90:95 32: w g:g :;: 3$ 94.60 33.44 lhigil 53.52 19.14 . . %.24 19.85 &---- 34.97 12.50 35.52 12.72 35.16 1.2.41 30.33 lo.84 31.65 u.34 34.37 12.13 me L9.59 7.00 20. o1 7.16 20.74 7.32 553 197.3 550 196.9 560 197.8

●lhdifiduel dsta on sepuate taole. - -or (F) =1/1~~‘~f ● , U(veight ), h(heiglzt ) smEc’rm mAsmmm9mR cc24PARIsoH- U.S.DEFT.OF MRICULTUREMm

Avemso d values U.S.D.L A& GrmP (35-~. ) U.S.D.A @e GrOUP1* GrqM l&U N = M5, w(61.U kg) lr *6253 h(16.04 dm, 63.3 in. ) q31.$Q-kg) F . 2.960 h(13.82 dm) F s 2.252

d %luee cm d V81W8 cm d Values Che8t 29.12 G3 30.04 e7.7b 30.09 WStbi.1) 25.63 74.55 25.29 25. b5 mlttocka 32.40 99*34 33. % ::: 31.92 Thigh U.& 57.00 19.25 . 18.50 33.22 11.22 12.17 Knee M 35.30 U.93 ::% =.89 8.42 .24.89 8.41 .------Urlst 15.26 5.16 .--.------Aukle 7:2 23. bo 6.98 ------.---

am MO. 5 1s.8

IND1 VIDUAL DATA

GmQPllI =10 M& Weight= D2 x h“ i X .255 D.sumuc@N

Ho. Age Ed@ Weight Weight m Circm. h is height deolm. 00s. cAlc. * m Indm

14 35 15.13 57.7 %.1 574

m 36 15.49 49.3 49.5 534

24 23 14.92 40.9 41.tJ 497

30 14.92 58.8 59.7 594

1050 30 15.b7 b2. T 03.0 boo

1502 25 15.49 56.4 53*9 557

n % 14.41 56.6 55.7 w

- 25 15.37 50.4 49.0 537

51 35 14.90 1+5.O b.2 523

832 26 lk.07 45.9 44.2 52b

30.3 15.10 52.4 52.2 553 128

— Graxpllm. lo

Ho. Heignt Weight weight Sam cm. Decim. 008. Cslc. m

835 30 14.61 43.6 43*5 5U

841 3 16. q 61.8 59*5 578 843 35 14.61 58.4 57.4 587 865 s 15.18 Wb.1 42.5 % %7 s 15.03 52.7 55.8 m @5 34 15.18 54.5 54.6 %5

w 24 1.2.59 45.5 43.5 538

932 29 14.48 47.3 46.4 529 934 29 14.73 64.3 64.4 620

945 39 14.61 40.0 40.5 493

31.8 lk. n 51.2 50.8

------>------● Calc. Weight (kg) = (SumCircus. /lW)2x h“7 x .255

------Gravid?49 25 15.49 75.5 74.2 739 (I2 Clrcm. AtId(l) & 2 ~v n 61 la 15.37 76.4 74.6 742 “ “ “ “ w!! 74 26 15.43 82.0 81.2 773”””” ------uc. weight (kg) - (SUR 12 C_112.9)2 x h“7 X .255

12 Clmx4mferencea = 10 circus. + AM (1) ad Ad (2) (u. ” = 10 cl-. + m (avg. ) 129

Height Welgkt Calc. wt. *IL Si181a — “L- Circnm.

590 196.2

Groupll----- N ----= 10 16.15 70.8 6L6 193.8

----GroqlU ----IV= 10 15.58 61.3 %8 196.3

----GroqlVN= ----10 15.80 61.6 586 196.1

-1 GrcuEI IL GrouplV clrcu8. Me8a/F Mean Meax#F *- Mean]F cm d cm d cm d —— —— —— —— Shoulder 107.1 35.92 109.6 34.60 102.9 34.35 103. L 34.60 MC- 31.65 10.65 33. U 10.42 31.53 10.53 29.12 10.32 Fo~ 27.64 9.30 28.54 8.98 z7.47 9.18 25.75 8.63 wrist 16.54 5.57 17.46 5.49 17.48 5.84 17.40 5.82 ------Cheti 90.00 30.00 95.05 29.92 91.32 30.49 91.96 30.82 AM=) 76.05 25.54 84.40 26.56 82.63 ~.60 86. ti 28.84 89.95 30.I.2 95.45 30.05 90.16 30.10 91.67 30.70

-G&i--- 52.72 17.99 56.38 17.74 n. 91 1?. 34 n.~ 16.90 Knee 36.51 u.17 3&.33 1.2.05 36.75 =.29 36.75 u?. 32 34.63 u.69 36.53 u.% 3b. 34 U.47 32.38 10.84 Ankle 21.09 7.19 ZL.61 6.& =.32 7.12 21.30 7.13

196.14 194. U 196.31 196.92 130

-----Groql N-19----- Av.w~o-- ~~111------E=lOAv.------Age58- !’Wbez- Sam IJ Clrcum weight Weight Number m u Circum. Weight Weight cm ma. ~~.* cm as. WC.* —. 37 604 s w 55Q 52.7 55.1 70.4 71.4 : :; E Tr.o 77.2 582 57.3 882 555 55.7 973 583 58.7 E:; 885 592 63.2 z:; 947 53.1 840 z; ::; 71.4 w 600 67.3 67.8 70.4 68.7 1501 617 66.8 853 625 51.1 823 588 63.2 w 549 53.7 9: 559 54.5 55.8 77 5*(h,15.X) f~~.~)~ 55.8 61. b 600 60.O 10 65.2 8K ?; 87.7 87.7 27 64:1 65.8 E 6$: 66.9 ------2 57.8 Grou~ lV M a 10 ATT.&e 73 6% n:6 71.9 --- - 8Z 5n 57.7 59.4 540 50.2 51.3 828 54.0 53.6 8Z 553 51b.1 55.7 830 E 67.4 553. 833 591 2:; 65.4 E 593 z:: 2:: 836 554 57.3 57.5 8!3J 668 7-J.; 77.5 ------;= ‘~- ~ ; 7Q-A;.-~-~ 55.9 gla z 85:5 87.8 842 6M 67.8 w 603 61.4 63.5 660 E:: 82.4 ;5#h,15.36) (;$* 55.6 9; 657 83.6 8L.2 $ . 57.1 7 60.2 4 g $:: 67.5 And Stature 15.50 dnl, weight Cdc. 2; ;:; 2:; Stature lefi blank in ~ocol Ca.1.c. E g.; Weightbasedon ae~ (H). 15.36 68 575 60:0 . dec~ers. ------Remarks Calsu3ation of weight. Sumll Circua.l~=D & x Height”4 x .263 = Weight(kg) 1.0 The equation,D2 x Height x.111 . Weight (kg] gives a good approximationalso of veight. With this equation,calculatedveighta are lower. For the Rongelapgroup, the correct power of height lies between 0.7 d 1.0 131

18terpretation of Data.

lhe d valnafor Group1 reflect @od IMIS* deve~ti and leanness based a vlth on — c~ison the d valnes of a Reference (Military Man)* and other groups.

The d valuesfor Grmp lV reflect loss of lean tissue and fattenlng

that acc~es the aging process.

‘Rtedvalues of Grcupllme ~t puzzllng. This group does not

have the muscular devel.ogment, for exaqle, of the older age Group Ill,

despitethe increased weight of this group. The number of individuals in

each group except Group 1$ Is ~, however. There Sh-d be at least

sOmenin each group. Nevetiheless, there is no question about the exce~ent

lllUSC~ devel~zzt of GrcaaP 1. The relative4 - anklesc~ vith

Reference&fan*w be a physicalcharacterlaticof the males of this race.

——— ——. . .. . — .. —----- —— — * ~rermce (M..M- MSZI)Age group20 - 24 yews. we- 7Q.O Q.

Esight17.@ decimeters (68.5 Inches ).

x of 11 Circumferences = 600 F = 3.078 * I.1 Cm=. /F = 194.9

d Values for Reference!4MI

Shoulder (36.00), Biceps(10.32), Foremn (8.?2),mst (5.62), chest (29. U), AMomen Av8. (25.49), M@UI (30.36)~ TM* (17.80), hee (IL X), u (IJ.6k), -e (?.31) 132

Conclusions.

1. Tb ~ @ t~ G- ~ to 29 ~, eqeciX, reflect eXCdhUt

~iC81 develqmen’t. The IIvelue for bicepe girth is 10.65 C~ with — 10.32 for a reference military (YOUU6)nmn?(A differencegreater then

0.20 is Mghly Significmt).

2.WC oertrwt,the~ (WS 24 tO ~) viththe exc~iorl Of the

UM ~a are either pbyeic~ ~ure, or they Mve loet ●

considerableeaouat of leen tissue.

m striking -turity is ren.m=ted in * girths Of hips and thigh.

The d valuee for these meaauremerrtsare much lover than the c~le d

values for a reference Vmanardfor the man values for a group of American

~meMured4b@1937- 1939 W tie ~. of Agriculture in connection

with gement patterns. l!hereMtively ~ size or #t CU nnacd.ature

iB UOt~rt@. The d valuesfor em sizecmpare ravoreblywiththemeof

a rwi?erence~ ~ ~~ -se Or tie ~A (35-39 F) 2Z’OUPS APPENDIX 10

Nausea and vomiting in MarshtileseFOllOWingExposure to Fallout,

— March 1, 1954

Nausea Sub ject Voaiting, NO. Age (19S4) Sex onset Duration Onset

2 2 M 3/1 (1200) ? 3 1 M 3/2 3 days 3/2 and 313 4 38 M 3/2 1 day 5 2 M 312 L day 3/3 9 22 M 3/2 ? 3/2 10 2k M 3/1 (1600) 1 day 11 50 M 3/2 ? L4 2s F 3/2 (1200) 2 hours 15 7 F 3/2 ? 19 3 M 3/2 ? 20 7 M 3/2 1 day? 21 3 F 3/1 Or 3/2 ? 3/1 or 312 22 17 F 3/2 (0700) 5 hours 24 13 F 3/2 (0700) ? 27 26 M 3/1 Or 312 ? ? 32 3 M 3/2 3/2 33 1 F 3/2 3 days 34 ks F 3/2 (1200) 12 hours 36 7 M 3/2 2 daya 3/2 37 20 M 3/2 1 day 39 15 F 3/1? 1-2 days 40 29 M 3/1 (1200) 2 days 42 3 F 3/2 2 daya 3/2 43 66 F 3/2 1 day &g 15 F 3/1.or 3/2 1 day 54 1 M 31L or 3/2 ? 58 59 F 312 (0800) 4 hours 61 8 F 3/2 (1200) 4 hours 62 57 F 3/2 (0600) 6 hours 63 36 P 3/2 (0800) 4 hours 64 30 F 312 1 hour 65 1 F 3/1 or 3/2 1 day 66 29 F 3/2 (1800) 12 hours 67 14 F 3/2 (1200) 1 hour 68 45 M 3/2 (0800) 4 hours 69 4 F 3/1 2 daya 71 28 F 3/2 (1000) 5 houra ? 72 6 F 3/1 or 3/2 ? 74 L6 F 3/2 75 12 F 3/2 1 day 77 26 n 3/1 or 3/2 1 day 78 37 F 3/2 (0800) 4 hours 80 46 M 3/1 (1800) 1 day 82 50 M 3/2 1 day

NOTE: Totsl of U Ca~*S (69%) of 64 people raceivfw175 r reported nsusea in the first 2 dsys after exposure. No nausaa was reported in the 18 Ailingnae people (receiving 69 r) or in the 157 Utirik people (receiving 14 r).

133 APP2NDI~ 11

PediatricAntbrqx=etcic Data (Height and Weight) 00 RongelapControl (Unexpo8ed)Children, 1 19S7 through 1964 .— - —— _——.. .—. .- .- —..—— — - 1957 1958 19s9 1960 1961 1962 1963 1964 —-- — — —- — -... — .—. .— . .— Birth Mt., Wt. s Ht. , Wt. $ Ht. , wt. , Ht. , wt. , lit. , wt., Ht. p wt. , Ht.. Wt. o Ht. S Wt.* No. Sex date a lb cm lb m lb cm lb m lb a lb m lb m lb — .—. —- ——.. —--- — ml u @9/% && 81 t37 w 23 97 100 34 ml 108 $02 M 3/16/$ -- 101 106 38 Ill i; 118 i% 603 M 3/10/56 71 g : 100 -- 1o11 108 38 U2 43 118 46 ------13@ 2,25$$ 74 ------805 F I!x G lZ 112 G 119 121 ; 126 ~ 130 ii -- ti M v /55 ~ 96 104 39 108 118 --- -- 807 u 6/13/55 : 95 104 WY 112 40 117 41 60s F 3/29/55 In 68 96 ;: ;: 109 113 c 118 --- f@ M yy~ 76 a 99 102 32 107 113 118 :; 124 G 52 610 F / 91 99 105 112 39 118 121 : 126 132 57 611 F 2/14/54 85 93 99 los 3(3 111 14 46 118 5J 125 57 ts12 F :$2,&% 86 96 102 ~: 115 -- 124 130 59 813 u 95 102 109 113 117 G 122 126 E 81.4 M b/5/52 z 105 112 116 50 122 125 130 134 z F15 M 5/4/50 113 119 125 133 136 2 sbl n 149 ~ 616 F lo/31~9 116 U22 127 :3? ;: 136 M 80 150 94 152 104 gl’1 M lo/19 50 116 121 -- 130 69 13g ------l!ll? M 3/4 / 51 llh 119 125 130 138 142 75 146 82 819 M 12/15/4u 132 — 135 1# : i! 349 E 155 111 165 123 820 M 10/25 e 124 las 121!I ti6 152 157 106 161 109 821 F 8/1 P 7 122 129 135 z 146 lM lg 148 114 148 127 822 M 12/26~5 132 136 &l :: 154 1* 112 159 120 160 169 823 M 6/11/43 152 1* 162 1% 165 16s 126 ------.- ls& M hhm % --- -. -- 160 164 131 ------825 F 3/9g 151 152 152 153 124 ------826 F 154 -. -- — — ------827 u l@o/bo 157 157 1* -- -.. ------82$ M t3/26/40 150 151 -- -- -. -- — ---- .------F@ F /39 152 ------830 M 9/9/36 MO 162 ------. ------$~1 M 6/?.l/39 152 157 160 160 125 — ------8b3 u 6/25/50 112 117 123 127 60 133 136 70 140 147 ii 8k16 F 7/ /55 m i35 -- 105 110 41 114 119 h7 69 M 4/ 9/46 130 134 $: ii 88 155 -- — --- .------— .—. —. . —. .—— —.—._ . —. ._ ._-_. .—___ ——. 1957 19S8 A95Q 1960 1961 1962 1963 1964 —- .— . . —z- .__. Birth tit., wt. , Ht. $ Wt.j Ht. c wt., Ht., wt. , Ht. S wt., Ht.t wt., Ht.t wt., nt.. Wt., No. Sex date a lb cm lb cm lb m lb all lb a lb m lb a lb ——-—- -— ....-.—. .— . ———_ _ -——.— -——- -— tqo M 2/21/56 62 24 27 100 31 106 35 111 116 ml I?72 M g /43 lx ii; 102 lg l& ------q~ Mg P A6 133 59 :3? 6a lJ45 !31 - -- -- 168 --- 4s76 ? 160 120 ------— ------S79 F 4/ 7$ 61 24 93 ; ------126 (M5 M lo/17~8 120 165 135 ------84.?7 M lo/19~ L? ti6 ~ 153 z 1; lQ 165 105 169 ------891 F 5/15/48 122 2 126 130 65 43 150 152 692 M ;;;7g 12~ 132 6 138 4 154 2 1;; --- 161 8% F 137 z 139 100 139 1(M -- —— ------* F 7/ /57 .- 68 18 82 23 -- — .- 111 --- 901 F ?/12/57 -- . . 67 16 23 -- -- ; 100 105 111 902! F 10/23/57 -. — 63.5 12 ; 21 -- -- 93 ;: 103 110 903 F 11/19/5’I -- 57 19 ; 101 107 94 U 12/22/57 -- -- ~ 22 -- ; ;: lol 107 113 905 ; 10/23/57 -- -- z 19 91 27 102 L(36 * 3/1/g -- -- &l 15 25 ;2 102 107 903 F 3/ll;~ 109 -- X20 % lg 137 141 911 F -- -- 101 1043

1017 M Age ~t62 — ------* 22 90 96 29 --- 101J3 M 3/17/60 -- — ------78 --- -- 93 ‘i 1019 F l/l&/60 .------80 --- -- 95 31 ------— 1020 F 7/15/59 M 27 95 29 1021 F 5/11/59 -- -- -. — ------22 ------1022 F @@j9 ------& ..- ‘G G ‘G 104 M 11/13/59 -- -- ;i 25 85 100 1025 F 6/13/59 -. ------18 gl g 2 94 : 1026 F 5/28/60 ------w 26 97 1027 M 12 /60 -. ------; 82 23 87 : ------102(s M 2P22/61 -- 71 22 1029 y/g/61 ------26 ;; ‘G 1030 : 3[26$; -- .- — ------72 --- 26 91 29 1031 ------— ------75 86 26 -- 31 1033 M ------Cl ~ Age @ 143 86 150 105 -l lox.1 — ------z 106 113 1035 F 4ge 3?%2 ------— 45 146 $ 146 1; 1036 M Age X)162 -- -- lq 131 60 134 67 1037 M 9/18/61 ------6S --- 20 --- 25 ------103LI M 10/31/61 66 74 24 84 27 1039 M 12118/61 ‘------.- --- 22 10I+O K 9/24/61 z --- 25 87 29 1008 F 6/24/58 --- .- 95 32 1013 M 9/23/@ --- -- .- -- 1044 F 9/17/62 --- :: -- m46 M 10/ 9/62 --- -- !% 1047 M 12/28/62 .-. -. --- 19 1051 F / /55 --- .- 124 --- .- 1052 :;$$ 132 z 1053 --- -- 99 34 1054 M 11/29/63 --- . . --- 15 1056 M 3/4 64 ------9 1057 F 8/ ( /63 ------15 1o58 M 1/16/64 --- .-. 1503 w ‘G 96 3: 1504 : /’ $2 --- 21 85 25 APPENDIX 12

pediatricAnthropcmetricData (Heightand Weight) on Children Dorn to Exposed Parents, I

1956 through 1964 .— — . ——. — ——— —..-—- — —— . — 1957 1958 1959 1960 1961 1962 1963 1964 —— — —.-— — —— —---

Birth Ht.S Wt.s Ht.t wt. , Ht.. Wto$ Ht.. Wt.t Ht.j wt.* Ht., wt., Ht., wt., Ht.. wt.# No. 6eX date en lb aa lb cm lb m lb m lb a lb rm lb a lb ——— .— — @q* F l:yly% 97 30 105 112 115 118 tm* M 31 9S 36 103 loel 113 118 m’ k! 12/2ff/55 28 95 22 100 105 109 115 M 11/29/55 ~ 101 36 109 113 120 120 $ M 1/ 5/55 ld 38 110 116 129 124 92 F 3/16/56 28 5$ 33 101 106 111 117 u 2/17/57 27 32 100 106 110 116 z F 10/ /56 26 -- -- 95 100 105 107 95 F’ 2/ 5/56 26 * 32 105 109 llk .“- --- L 96 M 2/12/5(5 23 63 29 90 97 106 co m 10/31/57 -- 96 --- 113 ;: M 3/ 5/3 2 -- 85 91 95 101 100 F J@6/56 33 z 35 102 --- 117 101 F wg 69 101 106 102 M 18 t% a 93 99 105 111 103 F 512$158 16 -.. 94 106 1OI$ M 10/2/50 17 -- — z 3 105 105 ; 1~/9/% 16— 85 92 1o-1 106 ;Jl#% % iii 3 103 107 F -- 22 ------1o11 F 12/1 475!J 24 a 95 98 109 u 1/ 7/60 21 95 114 110 M 12/5/59 z iii w 98 111 M 5/24/59 83 23 88 96 112 F 6/ tI/59 tlo 23 87 93 113 M 2/27/61 20 ------115 M 8/16/60 -- 21 80 87

—.—.-.-——. -. *Data for 1956 on the first five childre~lare as follows:No. 87? 16 lb: No. ~8# 58 CJII*15 lb; No. 89,.—.13 lb: No. 90, 62 CM, 11 lb; No. 91, 75 ~, 22 lb. — —— _.. — ——--— —-- —— ——...- .--— -—- ---—— - ______—---- __ .-. — —- 1962 1963 1964 —----— 1959 1960 1961 1957 1958 _.. —. —- _-. —.. ——— -— ——— ——— _—— — —-— ----— _- .--— Wt.p Wt.g Ht.* wt. , Ht.~ wt.* Ht., Iit.j Wt.s Ht.. wt.? Ht., lb Birth Ht.. wt., Ht.o wt., lb cm lb m lb m lb cm lb cm —.-— lb cm lb m -—. ——. — — - — No. Sex date m .— ------— ____ -_ -.. . _ -----— .-— — — _- -—--———————— _---— ------———- 71 78 m 89 25 62 26 92 29 117 F 3/26/61 68 --- 93 32 11s l:y;f6J 76 27 --- 28 120 ; 95 33 85.8 29 92 32 116 M 5/:5/60 ------. 119 F’ 7/19/60 w F 6/7/60 --- 26 94 30 Q 121 22 4,/] :/& 77 && F 56 -- --- 81 24 123 F’ 11/26/61 66 3.6 74 ii --- la F 10/23/61 17 81 23 88 G 125 F 6/ 161 2 16 73 21 81 24 126 M 9/26/61 --- 17 --- 21 w-l F 5/17/62 ------17 128 F 1/30/63 ------.- 130 M 4/19/63 ------13 131 M 10/28/63 ------13 132 M / /63 ------18 134 F 5/ /63 APPENOIX 13

Pediatric AmthropometricData (Height sad Weight) on Romgelap8xposed~ldren t

1954 through 1964 — 1954 (Mu .) 1954 (SeptJ 1955 1956 1957

No. s! Are at Birth Ht. . Wt. e Ht., wt., Ht., wt., Hto. wt.* Ht. t wt. * sex exposure date a lb a lb a lb m lb m lb

83 M In utero 6/a/s 66 15 ~ 20 & 2s 90 84 M ‘* “ 5/31/54 .- - 8St4 “ “ 9/17/% ? 66 17 z m 86 F”” lo/17/% Y 16 83

54M ly 2/21 s 25 80 2tS 90 36 9/3 65F ly2m 1252/ 21 23 79 a 133 W! 5M ly4m 1:;: 20 25 v z 3M lySm 22 : 25 z 2g : 31 ;; 2Mly4m 10/52 . 22 26 85 29 90 31 95 6*M ly4m 10/52 21b S1 27 95 wFly8m 6/52 23 a 26 ; ;: 33F ly7m 7/9 22 :; 88 21S 95 32 E 42F 3Y 3/51 - 25 27 92 28 97 31 100 21F 3Y 3/s 81 91 98 101 17F 3y4m 10/50 90 : 32 ;; m? ;: 109 23M 3Y5m 9/50 38 95 37 z ho 105 147 Uo 3z~3y6m 8/50 a 29 95 32 100 105 44*H 4 y 3/50 32 3.07 K’ 69F 3Y7m 7/50 95 33 G ;: 3.00 37 105 42 & 19M 5Y2~ W9 99 $ 32 105 109 U3 4*F 5y8m 6/L@ z 43 U7 E E U6 72 F.7Y 3A7 108 b LO 4Ab M 49 1.21 15F7Y ;J4J 106 35 ti 37 41 116 U 123 20M 6y9m Uo 43 43 :; k9 U8 125 36 M7y4n UN 1.16 M’o U9 m z 61F 8y 3/li6 M.1 2 3.20 z 130 ; 139 99 ?5 47 M8y5m 9/lb5 320 3.23 u 130 64 133 81*F 8y2= 32~5 u E $ U9 124 55 130 5WF 8y2m 122; U@ b8 122 &6 126 z 130 51 133 76M 10y7m 3!21S 63 130 & 135 65 138 73 lb3 75 Flly6m 135 79 138 I&j 91 us 100 Uk 26M 12y4m 1;% l&3 1: 150 Uo 15j 138 163 24F 13y Sm 9m I&& 100 99 U4 100 llb5 35M 13y5B 9/Q3 138 $ 94 155 105 155 u 1% 67F 13y?m 7/l@ 151 115 152 117 152 108 152 li6 1% 39F 13y Sm 9/40 14 l&9 lo2 l% 103 150 108 151 70 F15y /3s z * la!l 108 — 150 74F 15y9m 5/38 151 13L 151 IL12 151 137 151 22 FlSY9m 5/38 lg 320 1% 154 134 1* I.lo 49F 15yl.lm 3/38 150 150 w 150 127 150 ti5 150 73M lsy 3/36 170 :: 170 1513 170 156 12 F19y /35 lh7 96 3&7 13.2 37M 19Y /35 155 12s 165 172 141

1958 1959 1960 1961 1962 1963 1964

Ht. , Wt. e Ht.s wt., HteV wt., Htos Wt. $ Ht. . Wt. s Ht. ) wt. , Ht. * wt. , m lb a lb a lb a lb m lb a lb m lb 105 113 U7 w 127 58 131 6L 2 99 105 Uo --- Uk 58 * I.ol 108 U3 la ‘i --- -- 91 97 10b 104 U2 U6 44 --- .-

107 113 I.M E& 134 73 140 82 --- -- 93 9s 103 109 z 119 --- 102 105 u uk z lZ 107 109 Uo 65 1.14 : 103 log KL6 125 % 61 133 100 106 11.2 u 120 124 128 2? 105 Ill na J22 I-25 132 2; 140 107 116 121 132 Lkl 72 147 :: 10I3 U3 118 z w -32 58 139 a 110 115 la w L@ 145 87 117 128 3.33 139 146 ;: 152 100 U9 1.23 la 1% 138 142 87 147 97 113 25 w 132 64 137 n i17 122 3.27 131 .-. --- .- 120 126 130 13s z 150 G 155 101 119 123 132 137 lhl 76 149 84 133 139 R 151 154 19 103 155 104 132 139 U@ 153 15!4 160 126 157 137 130 136 u 152 155 U3 158 123 132 135 ~ 148 155 :3 11.2 159 118 1% 139 349 l% 163 X24 ------152 lj2 154 153 154 ------140 152 160 1.65 167 137 --- .-. 135 :; 152 154 155 ------L? IA9 153 1% 1% 154 $@ 155 102 153 162 166 --- .------i~l U9 lw 173 175 175 175 I.& lk9 g 156 152 160 w 155 155 155 7 =9 BEST AVAILABLE COPY

APPENDIX 14

Supplemerltary Anthrorometric Data on Rongelap Control Children .—. -. —.. ..—. .. — —— _ ..—- ...——. ____ --.--.— ———------—-— ---—. — -----— ---- 1957

Lower Upper Arm Head Chest Buttocks Subject Sitting ●xtremi ty extremity span, BiacroaAal Inter cristal Circ. , circ., Left calf circ. s No. ht. , in. length,in. length. in. in. width, in. width, in. in. in. circ.g i’n. in...... —— —. —. .—---—--...-.—— —-.——— ~—— --- —.— -.---—- —.-—— ml 16 12.5 10.2 26 6.5 5 17.0 17 7.0 17 F02 17 11 11.5 16,5 17 6.5 16 803 18 N 11 ~ :.5 :.5 u 17*5 16 w 17 15.5 32 29 7 M lf$ : 19 1305 20 lI! ti.!i 33 2:; 16 19.7 6.5 19 S06 19.5 16 13 : 6 19.5 19 19 1307 19 17 13.2 ;:. 5 8 6 lfi.7 18.7 ;:; lg. 5 19 15 12 30 7.5 6 IS 18.5 7.5 4 z 19 4 12 z 6.5 5.5 17.5 19 6.7 17 810 20.5 19 & 33.5 8 6 19 19 7.2 19 &Ul 19.5 19 w 31.5 7.7 6 19 19.5 7*7 15.5 612 20 lg. s IJ+.2 35 g.s 6 19 21 7*5 19.5 813 19.5 18.5 U.5 34.5 t5.o 6.5 19 19.5 6 19*5 sti 21 21.7 16.7 9 7 19 22 LI 21 615 23.5 25 19 & 10 7*5 19 22 22 616 25.2 26.5 19 9.5 19.7 21.7 ; 22.5 617 24.5 26.5 19 43 10.5 :.5 20 22.2 9 24.5 816 24 26 19 43 10 7 21 22 9 23.5 819 27 25.2 20.7 J+7*5 10.5 19.7 $.5 10 1320 25 29.5 21.5 49 12 ;:; l?. 5 >05 9*5 $: @l 26 2EI 20.5 46 10.5 g 20.7 4.5 10.5 622 25.5 30 22 51 11.7 9 20.5 10.5 33 “ 34 25 59.5 13 10 20.2 2.5 12 29.7 a :.7 33 24 20 25.5 11 26 g25 25.5 :: z ~ 21 30.5 11.2 28 g26 ?: ;; 25 4 21 26 10 30 IS27 32.5 37 28 z 15.5 9.5 22.5 34.5 13.5 34 IS2s 34 26.5 5$5 4.5 10 20.7 34 E. 5 IS30 ;: 37 213.5 16 11 21.5 33.5 k ;: @1 30.5 36 26 M05 22 12.5 32.5 k36j 22.5 25 M R*2 9 &5 19.5 2 9 22 (366 ti.5 12 29.2 7.5 5.5 16 7 17.5 tX$ :: 30.5 22.2 50 11 7.5 20 :.7 10 26 670 lg %.5 12.5 7 5 17*5 7 17 1372 29.5 57 27 2.5 15.5 9 20.5 211.5 11 29 gi’11 26.5 23.5 54 12 .6 20 24.2 10 26 1576 33*5 ;: 213 63.5 13.5 10 21 30 13.5 34 679 19.5 17 12.5 31 6 6 113 18.5 7 19.5 865 33 57.7 29.5 67 15 10.5 22 33.5 13.5 36.5 tm7 2&5 24 %.2 8 20 r, 33*5 12.5 25.5 10.5 27*2 &jl .5 a 20 47 10 9 20 23.5 g<>.> :>., ;* 9 29 p>. i, IIF.5 11 ~ 20.5 24.5 10 26 1958

Head tiead I{ead Chest Subject circ. $ width, length, Sitting circ. , Left calf Biacroaial Bi-iliac Buttocks No. cm as Ca ht., m an Circ., @l dia., w dia., cm c~rc.$ m —.-.— -. —_____ . —. ..——— —-. ———. -. ——_. —_. — .— ____ .— .— -... ..— 801 45.7 13.5 15.2 47.0 45*5 16.2 17.4 13.3 46 115.2 12.6 15.4 f+7.6 &5.5 18.2 17.3 34.1 47.3 80> IJFI.5 13 16.g — 19 18.1 13*7 ~05 47.5 13.6 1504 54.7 K 21 20.7 17.6 Z*5 ao6 49.6 13.I1 17.1 5303 49 20.2 Ml.5 15.9 49.5 807 h7&2 13.1 16.3 49.6 49 19*5 M05 15.3 &a gos 46-2 E*7 16 53.2 50.3 20 19.7 15.2 49*7 809 ~; 12 16.7 50 50.5 18.5 19.7 15.7 47 810 =.6 16.7 %.9 49.14 20 21.2 16 51.5 ml 49.4 M?*7 17.2 53.5 51.4 21.2 1!W3 15.6 54.0 83.2 L6.8 12*2 17.4 53●7 52.5 21.5 20.4 16 52*3 g13 47*5 13.6 16.1 53.6 52.1 20.7 20.9 15.7 52.2 F& 46.7 34 16.4 %.3 55.7 22.4 23.9 16.6 54.2 I!l!j h9.3 13.7 16.5 62.5 57 22.9 23.2 18.3 g16 50.2 15.6 17.5 66.6 57 24.1 24.6 19.5 Z.5 Slj’ 50.3 4 17.3 67 57 23.5 25.2 M1.j’ 60.a FM 51.2 13*9 18 65.6 513 23.3 24.6 Ml 60.5 619 51.4 4.9 17.1 72.2 65.g q.tl 27.3 20.4 66.4 W() $.3 4 16.L 66.7 60.7 24.2 27.1 18.7 63.3 $21 13*9 lIS.7 71.4 62.g 20.5 26.6 22.4 67 52.5 34.6 16.0 72.5 63.6 27.4 2i$.11 23.1 69.9 a23 52 13*II 17.7 78.3 70.2 30.7 >30 25.11 7a.g 825 53.1 13.6 N!l aJ -- 31.6 >30 25.3 -- @7 54 4*h 1~.ll! Iyj.tl 33.9 >30 25*5 626 52.4 14.3 18.2 gl.7 77 31.2 >30 24;9 77*7 630 55.9 34.5 19.3 E@Y a6.4 36.3 -- 27*2 i331 55.7 15 19.1 gj.1 76 32.5 >30 25.7 79 a63 50.5 4.3 17.1 62.9 59.2 23.9 25.2 lf%7 5!M 866 46. 1 .1 16.1 52.7 g~ 19.1 Ml 34.4 119 * g. t d .2 1.6.3 26 2(.3 21.1 67.2 !370 13 15.5 z 46.4 19 19.3 34.5 46:: 872 53.2 4.7 17.7 76.6 75.6 31.4 >30 25.3 gj’1.l 4.6 16.9 71.4 62.9 26.5 28.5 20.6 69.1 g79 ~.s 12.3 16.8 53.9 20.2 21 16.2 49 ISlyj 15.2 1s.9 Eyj z 34.6 2&3.6 13Ei’ 51.3 13.8 17.9 75.s 67.7 28.3 28.5 21.0 $ 891 50.3 13.1 17.5 67.3 24*3 24.9 19.5 4 @2 34.2 lLI 71.4 Z*5 25.5 27.2 20a 66.5 696 :.6 13.15 17.2 75.6 31.4 -- 900 143 11.ls U$.13 -- G*5 3.6.7 ; M! — 901 41.7 12.1 13.13 -. 41 17 13.6 12.9 902 ho.6 11.3 1$: 39.4 l&2 13.7 12.4 — 903 36.5 10.5 ● -- 36 13.5 -- 10.5 -- 904 39 -- 37*5 -- -- — -- COPY BEST— AVAILABLE

_. —— . . ——-—.. --- .-—. - - ——-— ____ .—— - ...—. .-— —..—.—.. ——— —______. .-. —- - _. —-. — 1958 (cent.)

Head Head Head chest Subject circ.g widthJ length, Sitting Circ., Left calf Bi acromial Bi-iliac Buttocks No. a a m ht.j - cm circ.t cm dia. . m dia.. rn , circ.s a —— —-- —— ——— —--- —.. — — .— ..-— .—. — — .—. -.— - — —- —--— 905 l.)o -- -- -. J@ — %*3 13.4 17.1 61.1 51 21.5 la.o -- z 13.0 16.3 56.2 53.5 z. 5 22.1 17.0 !# 912 t;.3 13.2 17.5 5%7 52*3 21*5 20.7 17.9 913 1+9.6 13.4 17.3 62*II 52 22.3 23.2 19.2 57.6 939 12.5 16.7 67:; 55.5 22.6 26.b 20.2 !?? 921 8.9 lf?.a 17.0 55.g 22.6 21.6 17.0 55.8 923 47.8 13.1 16.7 46:; 47.0 17A 1s.2 14.o 924 J&s 13.2 16.8 l@ 19 17.11 114.5 925 51.0 13.5 17.8 63.1 55 21.8 25 18.2 G* 5 != b9.h 12.5 17.6 63.2 21.6 23.3 12.7 57.5 930 47.2 13.3 16.2 w $5 19 18.7 14.o 931 M.7 13.7 16.5 51.5 51.5 21.2 20.6 15* 5 w. 5 937 &S.1+ 13 16.6 55.5 21.5 21.2 16.h 56*7 939 51.!4 &.% 17.7 7b.9 ::; 31 g 21.7 7h *o l&6 13.!4 16*7 65.5 25.2 20 62 *6 lg.; 13.0 17.2 63.1 54 23.7 l&3*4 57 9% 14*9 1802 20.6 ::; *30 24.6 115.5 E 952 f47* 12. i3 15.9 51.3 G 19.2 16.5 U*5 47 955 1413.5 13.1 16.9 62.2 52.7 23.2 22.9 18.5 % 959 51.2 ti.b 17.9 69.1 61.3 26.8 27*9 20.14 * W*3 13 17.8 6$39 545.6 24.2 23.4 NJ.7 $ 962 51,0 13.3 17.9 54.5 21.6 21.9 18 57*5 %5 52.7 Iy.1 lg.o 76.2 29.1 25.2 .- 79 %7 52.5 %*4 17.13 79,7 7LI 32.7 >30 23.5 971 51,1 13.9 lg.o 71S*9 69.6 30 >30 22.)+ 75*5 972 $.; 12.4 17.7 53.3 19 20.8 15*K 976 4.1 17.4 71.9 g 27.]4 2a 21.8 70.5 977 51:7 14.1 17.3 76 643.5 27.5 29.5 2j.f!l 69.9 5Q.JI 13.5 16.7 56*5 24 a.? 18.0 60 :; 147 12.6 16.6 &:; 45 17.8 N3.O $.3 $.5 91S0 W.7(hair) 13.9 17.1 93.14 22.3 21 961 45.3 12.7 16 52.9 z; 21 20.4 U*3 51.5 985 49*5 ljj. g 16.$ !%.3 20.2 22.1 16. ~ 53*5 986 46.8( hair) 12.9 16.2 54* 5 G*5 20.2 20.1 15.2 k9 966 45.f3 12.8 15.0 %5 I@ 21 21 15.1 543.5 989 52.3 %.3 18 66.9 27.6 29*4 20.6 w ~7.2 12.9 16.2 & 47 18.0 13.9 $; 993 52.2 gt.5 17.6 71.2 24.6 2.5 19013 995 43.6 -- -- — R. 5 996 1+7.14 ljocl M5.Z 55.8 49.2 20.8 21.7 16.8 != 997 116.’/ 13.2 16.% 61.2 55 23.2 24.3 17.3 55.5 72 Lx 91:~ 9: q 22.0 W — —.. . ..—. — ——— 1959

Head Head Head chest Subject Circ., width, length, Sitting circ.$ Left calf Biacromial Bi-iliac Buttocks No. cm m Cn ht., an a circ.~ u dia., cm dia.. a cixc.s a —- .. — .-———— &; 13.9 15.5 50.9 47*5 19.0 18 I.L.a ~ 47 % 13 15.7 rjl&~ 49.1 19,8 19.6 19.7 49.5 803 48:6 13.5 17.1 54.4 h9.4 19.6 20.5 14.9 l+9*h g:; 13.(! 15.5 5%8 54.2 21.!4 21.2 16.0 55*5 “ 25 lb 1?.5 57.3 51.5 21.5 20 17 52.5 *7 47.7 13.3 16.5 52.5 -- 19.7 16.3 46.8 12.8 16.2 56.6 50.4 20.6 :.4 17,2 53*5 % 47.2 12.2 17.2 %.~ 49 19.5 19*II 16.4 47.2 1310 48.2 12.6 16.9 !%3 50 20.1 21.4 1.6*5 :5 611 1+9.6 13.0 17*5 55.5 50.7 20.@ 20.6 ti.g 812 $.5 12.3 17*P Y*E 53 22 22.2 17.6 54 813 13.5 16.4 52*7 20.6 22.3 17 5#7 I?@+ lb 16.5 2:; 22.3 23.9 10 I!!l* 8.2 13.7 16.7 6&6 %.7 23.9 25 lg.1 61.6 51.3 130tl 17.6 68.2 59*4 25.5 25.6 21.5 2 13.9 16 66.5 23.6 61.5 mz 81s 51.2 24.7 19.4 S19 51.5 $.8 17.1 74.6 E; 28.4 213.5 21.9 66 620 4$; 16 69 25.5 27*9 19.6 59 /321 Ml 19.1 73*7 :.6 29.4 a 22.2 822 52:t U*7 18.2 74.3 66.5 28.9 30.1 23.7 2 623 52.4 15.14 1&6 83.1 76.5 32.9 >30 26.5 83.6 825 53.0 13.IJ M*2 83.0 32.8 -- 26 6 82-/ 53.5 14.2 la.s Sj.1 -- 34.0 * 30 * 30 631 56.2 15 19.1 85.1 33.6 25.0 &j 14.2 1-7.1 65.11 1?.2 24.1 25.s 19.1 2.5 266 ;:; 13.3 16.3 51 19.6 20 15.2 51.0 w &*4 17.2 ::; 27.6 2L102 22 65.6 870 46.6 15.7 E:i 19.7 19.4 15.7 ;~.6 Q4 51.8 2.6 17.6 ?$; 68.13 2g.2 30 22.5 867 51.3 13.e 17.F 78.7 69.6 30.1 22.0 650 50.5 13 17.3 70.1 2:; 25.4 19.6 ;.6 692 52.2 14.2 1P4.1 73.5 U 27 27.7 21 69 P@6 52.2 lj.l? 17.3 73.7 32.1 31 25.0 4.5 900 h5.7 12.4 16.0 -- Z.2 1 .3” 16.g 13.7 45*5 13 15.2 -- 1$ 17- &.5 i;.3 & 44.5 12.2 15.7 -- $:? lB 16.6 13.2 46*9 903 42.7 12.1 14.6 43.1 16.o 16.s 12.o 904 45.E 12.7 15.5 -- 45.6 17.5 16.2 14.2 ii — —— 1959 (cont.) I Head Head Head Chest Subject Circ.s widths length, Sitting circ., Left calf tliacromial Bi-iliac Buttocks No. m Ca cm ht., m cm circ.t cm dia.. m dia., (m circ.o ca ——. — 905 &.8 12.4 15.7 1$+.E 16.3 15.7 13.3 f12.5 .- 906 42 13 13.8 40.5 39*5 16 Mi!.6 39*5 911 49.5 U.o 16.7 61 53.7 23 23.7 18.0 56.0 912 I&Ml 13.2 17.7 63.5 51.2 21.2 23.1 17.6 55 913 13.6 17.5 65.6 54.4 23.0 2$4 20.2 921 ;~:~ 12.9 17.9 55.7 22 ,’ 16.0 z% 923 13.3 17.0 ~:~ 48.s 19.2 1> 15.5 49.7 925 51:7 J3.6 17.8 22.7 25 19.5 59.0 930 48.2 13.3 1.6.5 %:$ ;:.9 20.4 19.7 14.6 49.5 939 51.7 4.3 17.6 72.5 52.4 30.3 23.5 75.5 $4+0 48.7 13.5 16.8 E.g 25.6 24.1 20.4 63.g 952 47*4 ).2.7 1.6.6 53.3 E.3 19.4 19.& 15.4 47 954 47 12.6 16.5 46 le*2 16.2 14.6 -- 955 49.4 13.5 16.el 63.4 55.5 a 23 lg.fs 5%5 959 51.6 14.3 17 71.6 65.5 2&5 211.8 21.7 69 m W*4 13.2 17.6 24.7 25.3 19.5 61 51.9 13.4 18.1 2.5 Z*9 22.b 16.0 56.@ ?% I&b 16.0 83.5 82.5 ~:: * 30 23.7 0.5 971 ;:: lb M 62.3 74.3 . >30 23 83 972 49.4 12.6 17.9 55.3 52.6 19.5 21 16.5 51.2 976 14.2 17.5 75*5 71.8 30.1 2%6 76.5 977 z. 1 4*5 17.6 fn.s -- 30.9 30 ::: 81.2 978 13.9 17.1 6&1 57.6 26.2 25.2 979 ~ 12.7 17.2 47 19.6 19.5 15.3 & 980 4 17.4 :.2 52.5 23.fs 21.5 18*E 5’/.2 9!31 :;.3 12.7 16.0 % 21.5 21 16.2 51.5 9$6 46.5 12.9 15.6 54.5 W 21.3 21.4 ti 52.5 992 45*3 12.9 15.5 45 16.2 17 13.5 44 993 52.7 14.5 17.5 75.6 61.5 26.4 27.7 21 995 49 12,7 17.5 -- 49.3 113.6 16.4 14.6 :.5 996 47.E 13.0 1.6.4 57.6 50.2 21.1 2?.7 17.14 !%.7 998 52.5 13.7 lF.1 7504 65 26.5 27.3 23.J+ 1002 4 15.5 55 W*3 19 Q1.2 15.9 E*9 mo3 $.2 12.5 15.5 -- 44.5 . — — -- 1004 45.5 12.4 15mg -- 43 — 16.2 13.0 1006 42.8 12.2 %.5 — 41.5 -- 15.0 11.ls — 1009 3F.2 lot? 12.6 — X.7 -- 15 11.7 — 1010 37 9. ~ 12.6 -- 35.8 —- -- -- ———. -.- .—. .— —.. ——— -—..——.-—.—. 1961

Head Head Head Chest Subject circ., width~ length, Sitting circ., Left calf Biacroaiial Iii-iliac Buttocks No. cm a cm ht. , cm cm circ. , caI dia. , cm dia. , - Circ. , a —-- —.- _ ———. — —-. — .— —--- —-— ____ ———z .= 601 47.5 4.2 15.7 54.7 49.5 20.3 20.2 M*3 50.0 802 hl.b 13.5 36 !% 22 22.1 17.5 !2 603 13.9 17J$ 59 $.7 21.7 21.7 U*8 I 53.5 go7 & 13.& 36.7 55.2 50.8 ~.6 22 17 51 60& 47..5 13.1 16.6 :.4 52.6 22*5 23.2 17.5 56.5 E09 g.: 12.7 17.2 51.5 20.5 M.1 50.5 glo . u .9 17.2 61.9 53.2 22 ;:; M.f$ M eill 50.2 13.2 17.7 62.1 54.5 22.5 17.7 55.5 Eli? 50.1 3.2.7 17*9 6& %.4 23.0 24*7 18*2 57.0 813 49 4.1 16.7 55*3 22.7 2J.: 17.9 gti 50 u 16.7 6J+.6 60 a,.4 ● 1%3 Z*5 815 13.9 16.9 71 25.6 27.5 20 66.5 F16 z 13.9 17.l? 74 z 27.~ 27.6 23 73.5 817 52.3 14*3 17.5 75.5 72.l! 29.2 w 22.6 7.?45 151t! 51.5 34 M.1 71.2 63 25.9 26.7 20.7 6S.o 819 15 17.2 79 70.3 31 30 25.3 77 @o z:; 16.14 7403 62 28.2 30 21.5 71.5 + -J 621 55 ::; 19.2 61 33 31 26.!/ 1$3*5 622 % 34.7 MOT 79 7h05 32.5 27.2 60.5 t?23 53.5 13.7 19 67.3 f31.5 34*4 -. 29 eV.5 8214 53 34.2 l&2 q5.2 60 33.6 -- 25.2 85.6 863 51.5 34*4 17.3 69.4 61.5 26.3 27.E 20.3 66 J&l! 13.a 16.L 60.2 21.1 54.4 869 114*5 17.5 78.5 E:: 30.5 : %.8 77.5 l!70 l%:; 34 16.1 57.5 51.5 21 22.5 17.5 51.5 867 4 18 84.5 77*5 32 25.5 60.5 891 ;:; 13.L 17.7 75A -.. 21.8 74 692 53*3 ::: 1S.6 61.3 72.6 $.3 :.0 23. n 76.7 901 47.5 16.5 55 49 20.5 19.9 36.2 51.o 902 13 16.~ 51.5 49.2 21.1 1&6 15.0 51.0 903 !!:.7 12.7 16 -- -- 904 4ge7 13.4 16.5 Z*4 50.5 20.4 20.4 16.o G 905 47.3 13.2 16.5 52.5 49 19.3 16.3 15.2 4595 906 ::.: 15.5 1.4.6 h6.g 18.5 19 15.5 :;:; 909 13.6 1(5.0 z. 7 57.1 25.5 23.8 2000 911 51” 14.2 17.1 6&2 60.5 26.7 26.1 19.0 63.2 912 50.5 13.5 I-/oll 68.8 55.5 23.4 24.4 19.7 59.0 913 13.7 17.7 $.: 26.2 21.5 65.o 919 & 12.5 1’/ ; E*5 27.3 21 67.8 921 4;.: 15.2 17. tS 65.2 59 23:6 23.7 lg.6 59.5 92j ● 15.6 1-/.8 57.2 50.5 20.5 21.5 M!*9 55.5 1961 (cont.)

Hesd Nesd Head Chest Subject circ.g width 9 length, Sitting circ., Left calf Biacrcusial Bi-iliac I Buttocks NO. m a cm ht., M m circ., cm dia.r - dia., a circ.o a —. 925 51.7(hair)l~,g 17.6 68.6 59.5 24.2 27.5 19.8 63.2 926 50.6 12,t? 17.7 70.6 58.0 24.2 25.2 19.7 64 930 g 13.6 16.5 22 22.5 16 53 931 13.9 17.2 i%; ;:: 23.3 23.5 17.5 55.5 937 50.0(braid)15.~ 17.0 65.6 Y!*2 24.5 25.3 llL2 *.O 939 14.6 16.2 L13.5 77.8 3307 w g%o 940 $! 13.7 17.0 70 66.7 2799 27.2 21.7 70 %6 . 13*3 17.6 70*h 5%5 25 25.9 20.7 65.8 15.2 1s.3 81.9 33.5 -- 26.8 ls!j ;: Zz 13.1 16.7 93.2 51.0 21 21.6 17.0 954 1+6.Jj 13.1 16.7 Ml 1s.9 19.1 16.3 Z 955 $.5 15.3 17.2 g:; 60.5 27 25.5 20.5 959 34*5 17.9 77*7 -- 32.2 24 **5 51,3 13.3 18.0 71.2 63.5 27.7 :;.7 21.1 66 z 52 13.5 ML5 %.5 %.5 23.5 24.s l&8 62 %(braids) 13 16.1 78.3 -- — 26.5 131.5 -- z ;[ 53.5 18.1$ 64.9 lkU ;; a. 5 gel m 52.2 ?:: 18.1 $6 79 >1.5 -. 25.3 87 972 5Q.2 13.1 17.9 61.2 55 20.7 22.5 53*3 53.5 14,2 17.7 $2 -- 31.5 -- : 87.0 ;$ 51.5( hair) 13.g 1?.!+ 73.7 63.1 27.8 26.2 20.8 70 979 48.3 13 16.4 55.1 50 20.5 21.1 1s.5 50.5 51.7 llJ.2 17.7 6~.2 25.1 23.6 19.6 61 ;: lJ7*l+ 12* 9 16.3 62.8 $.1 22.9 22.4 17.7 55*7 [email protected] 13.2 16.5 61.6 23.3 21.3 23.J u 55 9e 4$5*3 12*tl 17 9 53.2 21.5 20.s 16.6 53 13 15.7 60 5395 23 23.1 17.6 L: t:z 13.5 16.t+ 52 20.3 15.5 G ~(halr) 4*7 17.s a 7?. 5 %9 31 23.2 w ~5 50.5 15.2 18.2 51 21 20.6 15.6 52.5 4’J 13.3 16.7 Z*2 55.2 25.1 l&9 5%5 998 14 18.14 153.13 2.7 29.6 26.3 79 1002 47.8 a 15.7 *.2 20.2 23.2 16.g 51.2 1004 48.5 13.5 17.1 ;;.5 19.2 19.6 15*I3 g*5 1006 46.9 13.2 16.2 g. 5 46.5 lls. fi 19.0 15.0 1009 4S.8 13.5 16.5 .- 149 ‘ 20.5 18 15 50 1o1o 47 -- — -- -- .- — 1012 47.6 12.5 17.4 54 50 20.5 19.9 2.8 50.5 104 M. 5 13 17.2 57.2 19 20.6 16.6 49 1017 45.4 12.j 16 -- $ 17.9 — 1025 46.2 12.9 16.6 -- -- .- .- — —.. - —. ——. 1962

Head Head Head Cheat Subject circ.# width? length. Sitting ciec., Left calf Biacromial Bi-iiimc Buttocks No. cm L= cm ht.. cm a circ.t cm dia., cm dia., cm Circ.s m —.

801 MS.2 14.3 15.8 55.4 51.3 20.4 21.1 16.7 51.0 602 47.8 13.5 16A 57.4 54.4 22.5 22.5 18.5 53.0 803 u 17.5 60 53A 21.5 22. g 17.4 52 805 E:: 14 16 62.8 57.2 23.6 24.5 20.1 807 [email protected] 13.7 16.5 56.6 52 21 22. tS l?.tl 51.3 S@ 13.2 16.g 63.6 55.0 22*8 23.2 17.6 57.6 809 &3 12.6 17.5 62 53 20.13 22.5 17.6 51.2 510 h9.3 1.2*9 17.2 54*7 22 23.7 18.3 59 811 13.2 17.6 :;.5 % 23 23.0 M*2 57.9 tJ13 $.: 16.7 62.7 57J4 23.6 25. I Ml.5 814 :.3 16.7 64.4 60.5 2J.: 26. g 19.4 Z!.3 815 50:2 16.9 63.2 . 27.5 20.9 66 g16 52.2 a 17.9 ;;.1 2j’*8 29 23.6 7b.5 616 52 4.2 M*2 71.5 iii 26.2 27*5 21.4 68.5 819 52.9 15 17.5 79*9 71.5 31.5 31 24.6 76.8 50 U*3 16.6 76*h 71 29.1 -- 21.7 76.5 82 55.4 2$.1 19.3 80 -- 32.9 31 26 79.5 W2 54.2 19.7 76.5 32.9 -- 26.7 05.0 823 53.5 13.6 18.6 2.5 in.5 3J*: — 26.5 87. s 51.8 17.4 67e6 65.6 ● 29*1 21.3 6S.5 2 4&9 M 16.IY 61.5 54 21.8 22.7 17.2 % 870 :.4 13.5 16.4 60.9 ‘21.3 23.6 18.0 51.9 892 I-4.5 M$*5 so. 5 7?:; 31.1 $.: 74.7 900 48.1 13.5 16.2 55.5 21.5 20.7 . 5j*6 902 hJ.;(braid13.2 55-2 Z*9 21.4 20.3 16.2 51.5 903 13 ;:: 53*Q 53.2 2od5 20 16.5 94 h9:2 13.7 17 55 52.5 21 20.2 17 :.5 905 M*2 13.4 16.0 53.5 49.3 20.1 20.6 16.0 47.4 906 ~6.2 13.6 WA 52.5 lJ9. 1 19.6 19 M. 2 4$3 911 51.7 (baidM*l 17.1 67*I3 61.5 27.2 26.7 20 912 50.7 13.5 17.2 69.!3 56 23.5 25.5 19.6 913 13.9 17.7 69.6 25 27.0 22.0 E.o 921 Z.7 13.2 16.0 65 :.5 db.2 25.2 19.5 62.3 923 50.6 15.6 17.5 56.4 51.5 20.4 22.4 17.5 55.9 925 52.& 15.7 18.0 63.5 25.5 27.2 21.3 67.5 930 49.5 13.7 16.9 E*2 53.9 22.0 23.o 16.3 54 —.. —— —— —.. ____ —— 1962 (cont.) I

Neti Head Head Chest Subject Circ., width. length. Sitting circ., Left calf Diacrcmial EIi-iliac Buttocks No. a a cm ht., cm c= circ.. ca dia.. a dia., Cm circ., cm — ...——-—.. —....-—— --- .. -.-— _—— ______.._~

939 53.6 4.6 18.4 81.3 35.5 V.7 66 $ibO 13.5 17.1 ;;.8 69.6 29 30.3 23.ls 73.0 952 ;.2 13.1 16.5 513.2 53.6 21.m 22.6 20.5 70.0 955 50.2 13A 17 69.2 65.2 27.6 26.6 20.5 70.0 959 ;:.: 4*5 17.6 7eLl\ 33.6 26.5 136 * . 13●4 18.1 74.8 i; 28.9 28.7 21.8 962 13.6 M*3 67 %5 23.5 25.1 19.5 l;.o 971 z:; 4 18.2 85.5 7&5 32.2 -- 25.5 m 992 48.3 13.7 16.6 55*7 50.2 19.2 21 3.6.2 993 54.2 14.8 17.8 82.3 31.a 31 26 2 995 50.6 13 lg.b 57*7 ;.2 21.1 21 16 53.0 $.6 15.3 16.6 62.2 57*5 23.!9 25.5 19.0 60.0 z a l&6 81.3 30.3 30.5 27.0 83.0 UI o 104 h9.6 13.2 17.3 50.2 20 20.3 16.13 1006 M 13.2 16.6 52 $.3 19 20.2 R 1009 49.7 13.5 16*E 50.2 51.5 21.3 19.1 2.2 50.5 1012 J#?.b 12.5 17.1 55.7 50.2 20 21.1+ 17.5 51015 1015 47.2 12.6 16.6 .- h6.5 lt3.5 17.E! 13.7 1017 lJ6.1 12.3 15.9 52 ~ols 16.6 19.1 15.6 fi.7 101PI 1$7.1 12.5 16.5 .- 17.5 M. 5 11+ 1022 1+5 12.7 15.2 -- 19.1 18.0 U.1 $ -- 1025 [email protected] 12 ● 5 17.5 -- 8 17.3 4:’ 1026 44.2 12.5 14.9 43.5 17 17.3 ;.5 ii 1027 116.2 ------1028 1+3.3 10.8 15.1 — G.4 ------1029 45.3 -- — -- -- 1030 12.0 16.5 -- G.5 18.2 16.6 15.0 ;;.4 1031 k 12.7 15.7 ------— -- -- 1033 53.13 34.7 16.3 69.7 66.5 28.7 26.8 23.0 -go 1034 M*5 12.9 17 53*5 50 19.1 20 16 1035 51.0 13.9 15.t? 74.5 2&g 31.2 23.2 78.0 1036 52.2 U.3 17.8 67.7 62 25 25.3 20.4 63.0 1037 Lo.$ 12.0 13.3 -- 36.5 -- — -- -- losg 11.4 4.6 .- 42.2 .- -. — 1040 :.7 11.5 4.0 -. -- ii ------1963

Head Head head Chest Subject circ., widths length, Sitting circ.~ Left calf Biacromial Lli-iliac Buttocks No. Ca a a ht., cm cm circ., cm dia., cm dia., m circ., a ——.. — - .——_____ 801 48.3 lb.3 15.6 57.0 52.0 21.0 17.1 53.3 802 48.2 13.6 16.5 56.7 55.3 22.5 ;:; 18.7 56.3 803 ---- 14.0 17.6 55.5 22.6 24.o 17.9 805 43.5 14.1 16.3 6?: ; 9.7 24.1 25.0 20.9 , & 806 52.0 lk.1 18.0 63.1 57.3 23.0 23.8 19.0 57.7 807 48.7 13.9 16.7 53.5 22.0 23.5 18.5 55.0 808 13.2 15.9 z:; 57.0 24.8 24.7 18.6 59.0 m $:: 12.7 17.4 62.1 54.7 21.3 23.’7 18.5 810 50.2 13.0 17.4 67.5 57.7 23.4 24.6 19.5 2:: 811 51.1 13.5 1’7.8 61.8 56.5 24.o 23.5 19.0 812 51.1 12.7 18.1 66.7 57.5 :;.; 26.5 18.6 z:: 813 49.8 14.1 16.8 63.5 9.3 25.9 19.0 &&.: 814 50.5 14.2 16.9 68.7 63.0 50:4 20.4 . 815 13*9 17.0 64.5 27.7 z:: 22.0 816 g: z 14.0 17.9 &; ---- 27.0 25.5 ::: 818 52.2 14.2 18.3 72.1 ;:.; ::: ----- 21.5 71.0 819 53.5 15.0 17.6 8#: 33.5 >30.0 25.4 80.2 820 50.7 14.5 16.7 74:7 31.4 ---- 24.6 81.2 821 55.8 14.3 19.3 80:3 ---- 34.8 ---- 27.8 822 55.0 15.0 18.9 82.0 77.5 35.0 ---- 28.5 $:: 863 51.8 14.4 17.5 70.5 68.2 27.9 29.5 21.6 49.2 14.0 17.0 63.5 55.4 22.3 23.4 18.2 56:8 PO 49.0 14.0 16.7 60.0 54.0 22.4 24.7 19.1 55.2 874 54.0 14.8 18.3 ---- 79.0 31.7 ---- 27.0 891 52.5 13.4 17.7 78.5 ---- 2f3.2 28.7 23.0 &; 48.8 13.0 17.0 ---- 53.5 21.2 23.1 18.0 54.5 g 48.6 13.3 16.5 !%.5 51.3 21.3 21.4 17.3 53.5 902 48.2 13.3 16.6 57.5 50.0 21.5 21.0 16.0 52.5 *3 46.8 13.0 16.0 55.5 53.0 m.7 a 6 16.5 54.0 w 49.8 13.8 16.4 58.4 54,8 21.5 22.0 18.0 W5 48.6 13.5 16.9 58.2 50.0 20.8 20.3 16.9 $:; * 46.8 14.3 14.5 55.0 49.4 20.2 21.2 17.0 51.0 w 52.0 13.6 18.1 73.3 ---- 27.6 &.2 22.0 75.0 911 51.2 14.2 ;;.; 68.5 62.2 28.2 fX.8 m.o 912 51.2 13.5 69.7 24.3 26.3 20.6 g:: 913 51.4 13.1 17:8 69.0 E:; 25.6 26.9 22.7 67.8 919 49.3 12.6 17.0 77.0 62.5 27.7 31.0 23.7 72.5 921 50.8 13.3 18.2 66.0 62.8 24.0 26.2 20.0 $.; 923 13.2 18.0 58.4 52.1 21.5 22.5 17.6 925 $:: 13.9 18.1 74.2 ---- 27.2 29.5 23.3 71:0 926 51.0 12.8 17.9 73.0 61.7 25.3 27.1 m. 5 68.5 930 48.6 13.9 16.7 60.9 54.0 22.,9 23.0 17.6 59.0 931 50.4 14.1 16.9 62.5 57.2 24.8 26.0 18.6 %.7 937 50.5 13.5 17.0 69.0 61.8 25.1 26.5 21.2 72.0 ,.: p(-)pf BEa t AL-D--- - . BEST AVA!LA=L CQPY

.-— _. —-— —— _____ .-. —- ——-— ____ .. —. _ __— —— 1963 (cOnt.)

Chest Head Head Head Bi-iliac ByttOCka circ. ? Left Calf Biacromlal lengths Sitting Circ. s m Subject circ. , width, dia. ~ cm dia. $ cm ht. . cm a Circ. s a a a —- No. m __-. .— -__.. _.- —--—-- — _. -—._ ..-. — —— ---— . . ---- 86.0 81.3 35.5 W.7 53.6 14.6 18.4 87.0 73.0 939 ---- 28.0 27.2 23.4 52.2 13.5 17.8 74.1 ------91.0 w ---- 33.5 15.2 18.6 82.3 18.5 55.3 950 53.8 21.8 22.9 13.1 16.7 58.8 74.5 952 $:; 29.1 27.5 21.7 17.4 71.6 68.5 92.4 955 51.2 13.5 ---- 32.0 31.0 26.5 54.0 14.8 17.8 80.6 23.1 77.5 959 ---- 9.7 28.3 52.1 13.5 18.3 77.0 20.0 61.5 960 f55.: 58.8 24.1 26.0 962 53.0 13.6 18.4 18.4 57* 5 18.3 57.1 22.5 24.2 972 13.0 23.2 24.9 18.5 16.3 65:0 54.6 3:: $@ ::; 13.0 ---- 32.6 31.0 25.0 14.9 18.o 85.o 55.0 993 54.5 $.: 21.5 21.9 17.0 51.6 13.4 18.2 20.JI 6&.; 995 %! . 25.5 26.4 49.7 ::.: 17.0 30.6 q.1 996 18.5 81.9 ---- 31.5 !@ 54.0 56.2 21.2 24.7 17.5 53:3 14:3 16.2 59.0 17.6 50.8 1002 4a.4 50.0 20.5 21.5 1004 13.5 17.5 54.9 3.6.3 50.8 ---- 55.8 50.0 m. 5 21.3 1006 E:: 13.5 19.6 16.5 53.3 13.8 17.0 ---- 51.7 21.7 1009 2Q. 1 18.1 16.7 50.5 12.6 17.3 53.0 50.5 54.0 1010 K 52.0 21.2 20.5 1.8.2 49.0 12.7 17.4 57.0 50.8 1012 52.7 19.8 22.6 17.1 48.9 13.0 17.3 58.0 ------1014 ------49.6 ---- 1015 . ..- ---- L6. 3 47.5 54.2 19.3 20.0 1017 46.5 12.6 16.5 19.0 14.3 47.1 17.0 ---- c:; 19.0 ---- 1020 48.5 12.7 ------1.2.7 15.5 ---- 52.0 1022 45.9 22.2 20.0 17.5 13.4 17.7 54.2 51.0 15.6 z:; 1024 ---- 46.5 18.1 17.8 c:: 12.5 17.6 ------1025 ------45.0 ------1026 ---- 45.2 18.2 47.7 12.1 17.1 ------1027 ---- 47.3 ---- 45.0 ------1028 ------47.7 ------15.0 47.0 1030 ---- 48.7 19.2 17.5 1031 47.6 13.1 16.8 29.0 23.8 77.6 72.4 68.6 27.4 1033 54.3 14.7 18.3 21.6 16.5 53.2 57.8 51.2 20.0 ---- 1034 49.6 13.0 17.1 30.0 23.7 14.2 16.8 74.9 ---- 29.3 1035 51.6 26.6 20.5 66.5 14.5 18.0 69.3 60.5 24.7 ---- 1036 52.8 ------1037 44.6 ------loo! 45.5 ------:;. : ---- 41.7 ------1045 41.9 ------40:0 1046 40.6 ---- 19.3 15.5 48.2 13.6 ---- 48.2 ---- 1503 48.2 16.L . ---- l’. 1,6 5 APPENDIX 15

Supplementary AnthrWcmetric Data on Children Born to Exposed Parents

1957 I Lower Upper Arm Head chest Buttocks Subject Sitting extremity extremity span, Biacromial Intercristal Circ. , circ., Left calf circ.D No. ht., in. length,in. Iengtht in. in. width, in. width, in. in. in. circ., in. in. ——.

87 18 14.5 12 29.5 7.5 5 18,5 18,5 7 17 88 16.S 15 27 7.5 17.7 18 7.5 17.5 89 17 14 ;; 27.5 6.5 ;.5 16 18 7 17.7 90 18 15 12.2 30 8 5.5 18.5 19 7.5 17.5 91 20 16.5 13.0 31.5 7.5 6.0 19.0 20 7.5 8 17.5 13.5 11 27 6.5 6.0 17.2 18.5 7.2 19.7 ;: -- 9 8 20 5 4 14.7 12.5 4.5 11.5 94 15 12.5 10 24.5 5.5 4.5 16 14.7 5.2 15 95 17 14 11 25 5.5 17.2 16.5 7 17 100 18.5 12.7 10.5 27 ; 6 17.5 19 7.2 18.5

—— .— — 1958

Head He@ Head chest Subject circ.c widthr lengths Sitting circ., Left calf Biacromial Bi-iliac Buttocks No. cm cm cm ht.. m a circ., a dia., M dia.t ca circ.~ a ———-.— -—..—-——— .-.—

87 47.5 16.2 -- 47.1 18.1 16 13.7 47 88 47.0 1:.5 16.1 47.9 49.8 20.5 19.0 15.0 48.2 89 48.5 12.9 17.0 47.3 46.5 18.5 18.5 14.1 44.6 90 48.5 13.3 16.8 50.7 49 20.5 19.8 15.2 48 991 49.3 13.5 16.6 52.2 51.3 20.0 20.5 15.3 48.2 92 46 12.5 16 -- 48.3 19.0 18 14.5 -- 93 46.3 13.1 15.5 44.8 44.5 17.5 16 13.5 -. 95 45.9 12.7 15.5 -- 4E.5 20.1 17.6 14.7 -- 96 36.0 -- -- -. ------97 40.2 12.0 13.2 -- 42.2 16.5 16 13 -- 100 46 13.5 15 -- 4E.5 18.2 17 14.3 -- x — I 1959

Hesd Head Head chest Subject circ. . width, length, Sitting circ. , Left calf Biacromial Bi-iliac Buttocks No. a m a ht.j a a Circ.o a dia., m dis., cm circ., a ——— —— —.—

88 48.4 13.4 16.7 50.9 52.0 21.3 20.0 16.0 50.3 89 49.6 13.3 17.6 49.4 48*4 19.4 19.8 15.7 46.4 90 49 13.4 17.2 52.0 -. 2104 20 16.2 -- 91 49.5 13.6 17.0 56.3 54.0 21.4 21*6 16.8 50.5 92 46.7 12.7 16.3 50.0 -- 19.5 19.4 15.3 -- 93 48 13.6 16.2 51.9 48.9 19.4 19.2 15.0 48.0 94 46.7 12.2 16.7 49.2 47.5 19.2 18.8 14.3 49.3 95 47 12*8 15.8 51.1 48.2 20.2 18.8 16.4 48.5 96 44.8 13.1 14.8 46.6 19.7 18.0 13.6 47.0 97 44.5 12.5 14.7 -- 46 18.4 16.6 13.2 44 98 45.2 12.7 15.4 44.5 18.7 17.4 14.2 47 100 47.8 14.2 15:7 52il 21.2 19.6 1603 52.8 102 42.1 12.9 13.4 .- 44.8 -- 17.0 13.7 -- 103 43.2 12.2 15.0 -- 41.5 .- 14.5 12.8 .- 104 41.5 11.3 13.8 -- 39 -- 1308 13 -- 105 40.5 11.3 14 -- 41 -- 15.0 12.1 --

——— .— — --- — .— ————-.— 1961 — .— ..—--- --——.. .—-——

87 49.5 13.5 16.7 59.6 51.5 20.7 22.5 15.9 53.0 88 49.5 14.0 17.2 57 55.5 22.8 23.0 17.5 54.5 89 51.0 13.7 17.8 55.5 50.5 21 20.6 17.3 53.0 90 50.5 1308 17.6 60 55.5 23.6 23.7 1$.4 54.5 91 50.8 14.2 17.5 60.7 57 23.6 24.2 16.5 55.5 92 48.5 13.3 16.9 57.3 53.3 21.6 22 16.8 54.0 93 50 14.2 16.9 56.3 52 21.3 21.5 17 53.0 94 48.3 12.2 16.9 53.5 51 21.3 19.9 16.3 53.5 95 47.4 13.0 16.5 58.8 51.4 21.1 18.5 17.0 55.0 96 48 14 15.8 52.3 54 23 20.6 16.2 53 97 46.3 13.3 15.4 53 50 21.1 21.3 16 53.5 98 47.7 13.5 15.5 -. 48.8 20.4 19 14.7 50.5 ._.. — —,- ————— — —-—-—— ~--— 1962 I

Head chest fli-iliac Buttocks Head Head Left calf Biacromial lengths sitting circ. s circ.~ ca Subject Circ. o widthj Circot ~ dia., cm dia.. CM cm ht., m (m _..—— ————— — --—— No. cm m .— - ---——- —. —- ——---— - _— — -—-———------56.0 87 49.5 56.8 23.5 23.7 17.8 14.0 L7.2 58.2 53.0 Em 49.7 21.2 23.0 18.0 18.1 57.8 52.6 55.5 @ 51.0 13.7 24.2 25.3 19.0 17.6 60.6 58.0 56.5 90 :.: 14.0 24.2 25.0 18.7 14.2 17.5 63.0 58.8 57.0 91 55.0 22.3 23.5 17.7 92 49:0 13.5 16.8 59.9 22.0 17.7 53.2 17.0 53.1 21.5 52.2 93 50.3 14.2 21.1 16.6 17.1 52.5 21.7 54.0 94 48.4 12.5 21.2 22.1 18.0 13.2 16.1 52.8 56.3 95 48.0 23.2 21.4 16.7 14.3 16.1 53.5 55.5 52.0 96 48.9 21.0 19.8 16.5 13.5 16.0 52.0 51.5 49.8 w 48.2 19.4 22.6 16.8 14.1 14.8 53.4 15.4 48.5 102 46.8 E:; 20.1 19.8 13.1 12.0 ---- 49.5 103 48.0 20.0 20.1 15.8 13.0 16.5 52.6 :J: 46.4 105 46.8 20.1 20.5 15.1 13.1 17.0 ------106 48.0 52:0 19.0 ---- 46.5 ---- 15.3 46.o 15.0 46.o 108 ---- 19.7 19.0 ---- 13.3 16.9 46.o 43.8 110 46.3 17.0 17.6 14.9 47.0 12.8 16.0 47.9 14.5 45.0 111 ---- 48.1 18.4 18.0 46. o 12.2 16.2 ------112 ---- 44.0 ---- 45.6 ------n3 ---- 42.0 ---- 42.0 13.5 ---- 13.2 42.0 117 ---- 43.5 16.8 17.2 45.0 12.3 15.2 ------118 ---- 46.0 17.8 46.3 ;:. : 16.3 13.0 44.0 120 ---- 44.0 18.2 15.8 ---- 122 46.8 16,6 ------13.9 ---- 42.5 ------124 41.3 11:3 41. o ------44.7 11.7 16.3 ------125 39.7 . ..- 126 42.5 11.2 15.1 I .—. .- —.. .-— --— _.__. ——. -_-__ .——-- —— -- -- .—. —-- —-- 1963

Chest Head Head Bi-iliac Buttocks Head Left CSlf Lliacromial widths length, Sitting Circ. s dia.~ UI circ.s m Subject circ. t circ. s m dia. ~ m a ht., Cm m —-—-— —- ———-— No. 9 a —— —------— --—--— ---- . ... —-. ___ .—---—” —-- ...... 18.2 56.0 22.2 24.0 50.2 13.5 17.3 63.5 54.7 18.3 58.5 87 59.0 25.0 24.2 50.2 14.1 17.3 58.2 18.0 52.0 88 54.0 21.8 25.3 51.5 14.0 18.2 20.0 59.7 89 $.: 25.7 26.5 14.1 17.7 2:: 59.9 90 51.5 24.9 26.1 19.3 51.5 14.5 17.6 65.1 18.8 57.2 91 56:0 23.0 23.4 49.1 13.5 17.0 61.0 18.5 54.3 92 55.0 22.0 21.4 14.3 16.7 58.1 16.6 53.5 93 51.7 21.5 22.0 R; 12.5 17.2 56.7 18.5 56.7 94 54.0 22 24.0 48.3 13.4 16.4 61.0 17.3 53.4 95 51.3 21.2 20.0 48.5 14.7 16.0 15.2 54.5 98 50.2 20.8 20.9 12.8 16.8 57.0 17.0 101 48.4 20.0 22.5 47.2 14.2 15.6 54.8 15.8 c:: 102 c:; 20.2 21.2 48.7 13.2 17.0 56.0 16.0 51.0 103 ---- 49.1 20.2 21.0 47.1 13.0 16.o 16.8 51.8 m4 51.4 21.2 21.3 47.7 13.2 16.7 55.8 15.7 48.5 105 ------22.1 49.5 13.4 17.6 50.7 17.5 53.0 106 49.7 19.5 18.9 12.5 17.1 56.2 51.2 108 47.9 20.8 22.3 15.9 49.0 13.7 16.5 55.2 51.8 16.3 49.8 109 ---- 51.4 20.5 17.8 k9.8 13.7 17.0 15.6 45.5 110 ---- 48.3 18.0 19.5 48.0 111 47.7 13.0 15.6 19.0 16.o 16.4 ---- 47.4 19.5 ------112 46.8 12.3 48.0 ------48.0 ------15.1 ---- 113 ---- 52.0 20.3 19.4 47.2 12.9 16.1 ------46.0 115 ---- 46.5 ------117 44.3 12.0 15.4 ------47.2 13.0 16.5 ---- 47.8 ------118 ---- 47.6 20.2 17.2 46.8 12.1 16.8 ------119 ---- 49.0 ---- 48.0 ------120 ------47.7 ------122 ---- 48.2 ---- 45.0 ------124 ---- 44.5 ---- 48.2 12.2 16.7 ------125 ---- 46.7 ---- 47.4 12.6 17.0 ------126 ------40.0 ---- lq 44.0 ---- APPENDIX 16

supplementaryAnthrow=tzic Data on Rowlw Exposedchildren —. .— —.-— September 1954

Lower Arm Upper Chest Subject Sitting extremity span. . Biacromial extremity circ., Left calf No. ht.j in. lengths in. in. width, in. length, in. in. circ., in. --.— .—.— — ——.. -.-——.———- 18.2 9 Q*5 6.2 21.2 19.5 ‘/.2 20.$? 12.2 30.2 23 20 7.7 20 31.5 ::: 25.5 19.5 8.0 22.5 g M 7.0 21 J3.o 21 21 37*5 7.5 X.5 20.7 8.0 22 19.5 39.5 7.0 32.5 21.0 8.5 24 20 44 7.5 36.5 23.1 9*5 19*7 15.7 34*5 7.2 27.2 21.5 7.5 31 30.2 63.2 10 53.2 32.7 13 17.5 37.5 7 30.5 22 9*5 50.5 ::.2 57 11 31.7 12.3 30 27 % 9 g 31 13 22 15 37.2 6.7 30.5 19.7 8.2 21 u 5*5 37.5 20 0 29.2 2.2 62.7 11.2 51.5 29.5 11.5 23 25.5 47 0 39 2’4 10 31.7 27*7 62 EI.5 53.5 32.5 12 21 14.7 35*5 5.2 30.2 19.2 26.2 23.2 ~8.2 8.5 39*7 23 ;:; 27.’2 23.2 50.5 0 42.5 27.5 11.5 7 30.5 5.5 25 18.5 0 ;:.5 2PI.2 62.5 11.5 51 32.5 12.5 21.5 1!305 40 6.5 34.5 20.5 9 23.2 22.2 39 0 21.5 8.5 23.5 31.7 57*7 11.2 i:. 5 28.7 11 26.7 25.2 53.7 9,2 44.5 25.5 10.5 13 13 25 4.5 20.5 17 7

Ailingnae .—— 25 15 5.5 24.5 i9. 5 7*5 i 21 18 34.5 20.5 6.5 l@ 25 20.5 ? z 39.5 22 53 25 7.2 36.2 22 ;:; - 70 29.7 :.7 9.7 [email protected] 32.5 11.5 ~ 61 24.2 9 38.2 20.7 9 ——______*l!xposedin utero. —-—— . -.--. ..— ——. 1955

Lower ACm Upper Chest Left calf S Sub]ect Sitting extremity span, Biacromial extremity circ., No. ht.. in. length, in. in. width, in. length,in. in. circ.. in. — —— .—— —— — —- 2 21 17.7 A 7.7 12.5 19*5 7.7 3 20.7 15.7 32 8.5 13.5 21 7.5 19.0 17.5 31.5 7.0 12.5 19.5 7.0 1; 26 26.5 45 9.2 16.0 21.0 8.0 17 22 21 37 8.5 ti 20.2 7.2 22 22 9*5 U*5 22 el.o 2 25 25.5 t 10 1.6.5 22.5 9 21 22 8*5 20.5 6.5 22 30 ;;*7 :?.5 13 2.7 33 12.7 23 21.5 20 39 20.7 16 23.5 9.2 a 32 35.5 60.b? 13 23.5 1o.2 26 31 62 13 26,5 z:; 12.7 32 22 19.5 38 4 20 t! 33 32 ; 13.2 16.7 6 z E 61.5 13.7 *.5 31 12 ;2 &*s 26.5 l&.2 11 19.2 24A 30 36 12.2 24 31 11.2 $ 22 19 32 7.7 u? 7 27*7 1o11 20.7 2.5 9.5 % $ 12 20 7.7 ;: ; 52 1::; 20.5 ~ 11.7 E 19.5 28 7.2 11 7.2 67 34 34 56 a 23 ;: 10 69 22.5 13.5 18 20.5 8.7 72 2 22.2 ?J.5 9*5 18 21.5 fl. fj 75 31 55 12 23 n 10.5 76 26.5 z. 5 55.5 10.5 23 26.5 10.5 g3* M 12.2 6.5 9*5 M 5.2 4’ 19.5 17*5 ;.; 7 13*5 20 8 85* 12.5 5*7 :.5 17.5 &* 12.2 10 20’ 5.2 15.5 2:;

Aillngnae

6 20.5 17 12 20 7.25 18 ;: :.5 12 18.5 7*5 :! z 26.7 &2 10 lg.2 21.5 6.2 25.5 10 19 9.2 70 32 : 13.5 23 ;; 11 81 26 v ; 10.5 18 23 8*5 .. -——- -——. ———. ——— ..—._. —.— —.—— — . ——-—--- —-. -— —.. ...- —-. —--—. - -—-————-—. 1956

Lower Arm Upper Chest Subject Sitting extremity span, Biacromial extremity Circ., Left calf No. ht.g in. lengths in. in. width, in. length, in. in. Circ.$ in. .—— .- ..— —.—— ——- ——— ——--— — .— - .—— — —— —— .—..-. 21.5 U@ 33 &5 10.5 20.0 . 17 34’ 9.5 4 21 E*5 21 33*5 6.5 13.5 20 I 8.0 25.5 26 47 9 18.5 21 9*5 23.5 43.5 10.2 M 21 8.5 25.5 2 1$0.5 995 16.5 21 6.5 25.5 26 h7 10 20 23 9*5 23 . 36.5 15.5 20.5 8 31 y5.5 62 :.5 21.5 33 12.5 25 21 39.5 9*5 16.5 9*5 31 34.5 61 4 27 E 12 31 36.5 64 a 28.5 32 14.5 a 21 3s 8 16.5 20.5 6.5 22.5 -- ti.5 20 31 ;: i 16 27 31 1; 29 27.5 b9 12.5 ‘1 26 11 32 34*5 &.5 13 L7.5 32 12 22.5 21 35.5 &5 15.5 19 8 27 29 5005 9.5 22 a.s 10 34 13.5 21 ;: 1: a 27.5 J 20.5 16 z 8 12.5 19.5 7.7 35.5 15 26 32 12 21.4 t: 10.5 M 21.5 995 $ ~. 5 9 l&5 22 9 G 32 10 26 30 11.5 213 31 57 10 25.5 25.5 10.5

30 3*5 12 20.5 G5 31 13 12 19 7.5

Ailin@~ —.

6 22 17.5 9 Ill 20 8 19 ;: 13.5 21 8 $ 23.5 22.5 42.5 ! 18 22.5 9 l@ 26.5 29 ldl 10.5 23 9.5 53 27.5 27.5 51 9.2 22 23 9*5 61 26.5 50 10 21 23 9.5 g —--— .—_. . *lZxposed ill utero. — .—— —. —.. — —.— .— 1957

Lower Upper A rn Head Chest Buttocks Subject Sitting” extremity ●xtrenti ty span, Biacrotsia’1 lntercristal circ. $ circ. , Left calf circ. c No. ht., in. length. in. length, in. in. width, in. width. in. in. in. circ.j in. in. . ,——— — ..- -— _._. ---

2 22 21.2 15.7 37 7.5 6.5 20.5 2005 LI.5 2005 3 21 20 26.5 8.5 5.7 19 20 8.0 5 20.5 :; 35.5 9 7 19 20.5 8.0 20 15 %.7 29 21.2 1+9 11 7*5 19.2 22 9.0 23.2 17 25,5 24 16 43.5 10.2 6.7 19.7 22 8.5 23.2 19 24 26 19 g.5 9.5 a.o 19.2 22 a.5 22*7 20 26.2 30.2 20 12 6.o 20.5 *.2 10 26 21 22.5 23 313.5 10.5 8.0 l$i 21.5 9 22.5 22 32 36.2 2 61 13 9 19.7 ~*5 11 23 23*5 *.5 la Q 11.5 8*5 20.5 10 23.7 a 29.2 36 26.5 14 9 21 26 33e2 30 z 5 4.5 10 21.7 E.5 z ;2 32 22.2 :; 16.5 @ 10 6 19 21 8.7 21 33 21.5 17 38.5 6.5 19 20 9 32.2 2; 213 63.5 15.5 ; 21 32.5 12.5 ; ;2 28 30 22 50.5 11.5 19*7 25.5 10.5 26 31.5 37 2g 62 4 ;:: 21 29 11.5 g 22 22 16 37*5 9.5 7 19.5 20 II 21 ~ 31.5 23 53 12.5 . 21 ~.5 10 26 % 21.2 16.5 38 8.2 7 19.5 9 21.7 61 31 34 26 & 9.5 21 29 13.5 35 20.5 u 3? 7.7 6 M 7 20 2; 32 $5 %5 14 10 22.5 :.5 12 * 69 24.2 E 9 19 21.5 9.5 23.5 72 26.5 28 21 b7 11 ; 20.2 22.5 9.5 75 31.7 34 25.5 % 13.5 8.5 21.2 31 12 ;; 76 26.7 35.2 26 5g.5 12 6.5 20 f+7 11 21!.5

g3* 21.2 19 & 34 9 6.5 19 19 8.5 20 * 18.5 u. 5 34.5 6.5 6.5 19 20.5 g 20 gcj* 19 19 a 35 7.5 6.5 18 19.5 7*5 19.5 ~. 18.7 17.5 12.5 31 7.5 5.7 lFi*2 19.2 a

Ailingnae

6 21.5 20.5 15 23 995 19.2 20.5 a 21 22 19.5 15 7 :.5 19.5 19.5 21 i 2fl.5 19.7 i; 10.5 7*5 19.5 23.5 :.5 23.5 l@ 3.2 30 21.2 1$9 11.5 g 20 23.5 9.2 53 27 22.5 52 10* 5 7 19.2 10 2.5 70 29*5 ;: 25 & 10.5 21.5 $ u 3$ Ill 2?6 30 22.5 ; 11.5 8 20 24 9.5 26 Head Head He●d Chest Subject Circ.* widths length, Sitting Circ., Left calf Biacromial Bi-iliac Buttocks No. (m Ca cm ht., cm m circ., m dia.9 c= dia., cm circ., os —--- -— —- — .— 2 52.4 34.0 18.2 59.2 54.5 22*5 21.8 17.0 55.0 3 & 12.7 1704 %*3 54.0 21.7 20.6 15.9 52*9 5 13 16.8 53.9 53.3 ‘ 21.a 20.6 16.3 51.5 15 $5 13.2 17.1 69 % 25 25-5 1905 , 62.5 17 13.6 17.5 57 23.2 24.3 115.3 59*5 19 $.3:; 34.1 16.5 2:; 23.0 24.5 18.s 5%3 20 15*1 17.0 70.9 z 26.5 27*7 20 26.5 21 49.5 13.5 17 61 55.11 22.7 24.2 lg w 22 w. 5 13.3 17.4 79.7 27.3 ~ 30 23.8 23 51.5 13.8 1801 65. g G 27*5 25 19.4 G + Preg. 52 “ 13.7 17.1 7tL8 ;;.3 >30 24.7 55.4 4.4 19.1 90.3 65.9 >30 2g.6 fJn.8 13.2 US*9 62.9 %.5 23.3 24.2 17.6 G 49:: 13 17.5 60.6 51.5 22.9 17.3 55 17.7 4.6 82 ;:. 5 * 30 25.2 .- w. ~d 16.5 74.1 65.8 29.6 26.9 21.tl 72 55.t 17.9 82.8 32.1 > jo 21..4 -- 34.1 16.5 61.1 51.5 21.5 22.2 174 55 ;:: 34$ 19.0 74.3 66 27.3 29 21.7 70.3 W*7 17.5 61.3 9 24 23.g 17,8 95.7 53.5 lk*2 M 84.2 34*7 30.2 21.5 86 M*7 12.9 15.6 5295 52 19.7 19*3 15.5 53 34.2 MO 84.4 32 >30 27.2 :;.4 17.3 65 25 24.9 19.1 z 51.5 .:.1 17.5 72.7 z 25.6 27.6 21 61 53.7 14*4 17*5 81.3 . :9 >30 26 -- 50.6 34A 17.1 7944 75 *30 24 74 49.6 12.9 17.6 54.6 W*7 22*S 21.2 15.9 53 g.; & 16.2 55.3 51.5 21 21.5 16Jl 51.5 12.7 15.6 53.1 50.8 20.2 20.3 16.9 51 47:5 13 16.3 52 h9.7 20 21*2 15.8

Ailingnse

h9 & 1604 54*3 22 21.7 3.6 55.7 13J+ 17.7 Z.9 51.5 21.2 21.8 M*9 57 ~’ 34*3 16.0 63.6 25.5 24.6 1.8.6 5904 52.1 34.1 l?.11 68.9 E*7 25 26,6 20.9 67.5 h9.3 15.2 16.7 75A 62,7 27.3 213.5 21.b 67.5 53.el (hair)ti.j 18.1 81.6 30 <30 28 G 50.5 4.7 16.0 72.1 G 26.3 27.5 21 i;.5 -

●lixposedin utero. —. ——- ...... -. .—— —.— 1959

i Iead Head Head Chest 1. Subject circa, width, length, Sitting circ. , Left calf Biacromial Bi-iliac Buttocks No. Ca cm cm ht. , m Ca circ. , m dia. , m dia., M circ.s cm — 52.7 4.2 18..4 60.3 51J5 22.6 22.s ll!l.o 54.6 49.3 12.9 17.4 57.4 22.6 22.3 16.9 !% 48.3 13.2 16.7 54.6 54.5 22.0 21.6 17.0 53 ●4 49.6 13.2 17.1 72.3 60 26.1 26.5 21.3 6fs 51.1 13.7 1707 66.1 %.1 23.5 25.7 19.s 62.5 ~: 4.1 16.g 67.3 23.4 25.7 20 60 15.3 17.1 $:; 26.1 w 20. !3 66.5 50 13.6 16.9 2.3 2~.6 25.3 1s. 8 61 51.9 13.7 18,1 6a. 1 61.7 ::; 26.2 20.5 65 51.5 13.7 17.2 76 > Jo 25.4 55*3 $:; 19.4 90.8 Q 34A 2g 92.5 49.1 16.9 64.2 % 23.7 25.2 la. 2 57 49.8 13.2 17.7 63.g 52.6 &*l 21 18.1 % 50.s 14.7 16JJ 75.5 613JJ 30 29.1 22.2 71 50.5 14.2 17 63.9 52.7 22 23.1 N!!.1 *.6 54.2 4.5 18. !3 75.5 66 27.7 30.5 22.4 70 51.1 13.9 lv.11 63.1 59.4 24.6 19.3 59.4 &*s a -- %:! a 30 93 $;: 13.2 :.1 55a 50.5 20.1 20.13 17.5 13 17.4 67.2 25.6 25.5 20.3 z. 5 52.2 4.3 17.9 76.9 z 27.9 27.6 22 6g.? 4.5 17.2 81 28 31 25.2 -- ;;.5 ti.6 17.2 I!13.5 76.1 33 >30 25.8 74.2

13 17.9 59.5 53.1 23.6 22.3 17 53.5 G*3 13.9 16.3 55 53.2 21.3 21.6 16.5 51*5 46 13 15.9 56 20.8 22 17.lJ l+e*4 13.5 16.2 54.5 :;.4 20.1 22 16.6 E.&

Ailingnae

h9.5 14.1 16.6 59.3 55 22.4 23 17 %.2 51.6 13.7 17.9 62.3 55.5 22.1 22.8 lg.6 55J+ b9*3 404 16.3 66.5 56.5 24.2, 26.J 19.3 61.5 4.1 17.8 72.2 61.2 25.6 2s.3 21.5 ~.s ::; 13.5 16.9 79.2 6a.J.l 2%7 29.0 22.g ● U.15 15.9 76.2 -- 28.0 **9 22.9 74.0 —. *Exposed in utero. —.—— ——— —.. .——. . . —— -- ——-.—— . ..— — —.. . .—- _ .- 1961

Head Head Head Chest Subject circ. , width , length, Sitting Citco # Left calf Biacromial Bi-iliac Buttocks No. a cm cm ht., cm m’ circ. , - dia. , a dia.> m circ. , rn ——- . . ..—— .---——— --—-———— ——.-—-—. ..-—— —-- .e— —— 53.6 w+ 18.8 63 59*J4 24*5 25.5 19.0 ‘ 60.0 50.5 15*2 17.6 60.3 60.8 25.0 23.5 19.0 62 g; 1304 17.0 57*5 23.7 22.9 17.4 57.4 13.3 17 .J# $:; 2rL3 29.2 24 51.3 13.s 18.0 71.3 ~.6 25.9 27.5 20.1 E*5 50.7 4.2 17.0 71.5 63.5 25.4 27.2 21.2 67.0 $ 15*5 1s 70.3 29 30.4 22.5 75 13.7 17.2 2.3 62 25.2 26.1+ 20.6 67 53*3 u 16*4 72.i+ 66 30 28.1 19*5 91.s 88.5 37.2 ; : $:; $:: 17@ 67.6 60 25.5 27 19.2 61 ~2*3 13.2 17.9 68.6 57 25.+1 25.2 19.5 62.7 15 lti.o m.g $.2 32 30.8 23.5 ::4 17.2 M 23.5 25 19.5 E*2 :.; 19,5 >go 32 &*3 *.7 . u la Z.7 62.5 25.lY 26.5 20 64 M.h lg.!+ L35.5 -- 39 100 2.5 13.2 16,4 60.9 21.2 22 lj’.g 50.5 13.2 17.7 72.5 2.5 28.1 27*I+ 22 2;.9 53*5 lf4.5 14s.2 132.1+ 32 31 26.7 S!j 51.1 13.2 143.2 65.3 % 25.5 24.1 lg 49.4 4*5 16.&I 60.7 5i3.2 22.5 23.7 1$ ~ 47.1 13.2 15.8 61.3 53*7 22 23.7 19.3 49 15.5 16e 5 %.5 51.5 21.3 23.5 17.5 53 Ailingna.

W*h 14.3 16.4 6$5 57*9 24.5 4.4s 18.1 61.4 52.5 11$.1 18.1 56.5 24.2 25.8 lg.e! 61.5 50.6 & 16.3 70.1 63 25.8 28.3 20.6 67 52.8 m 1 76 214.3 79*5 50 13.5 17 81.5 .- %.5 ;:. 5 23.2 76 55 15.1 16.3 iS2.8 30.5 30.4 25.1 65.4 --.--- *I:xpOsedin utero. ——. —-.-— —- —... .——. ._. _-— . ——.—.—— 1962

Head Head Head Chest Subject circ.s aridth, lengths sitting Circ. , Left calf Biacromial Bi-iliac Buttocks No. a cm a ht. , a a circ.9 U dia., M dia. , ca circ. ~ a __ —,.. -——. —-. .— —---— 53.9 4.6 19.0 59.3 $.: 26.2 19.1 61.5 50.2 13.2 17.IS 61.1 24.5 19.6 62 51.5 13.5 17.5 -. 30:0 29.1 25.1 79.9 52*I4 13.8 17.tJ 63.4 26.3 211.5 21.4 66.4 !5$$ 4.3 17.1 63.1 *.7 28 21.6 67.0 15.7 lEI.O ?9.2 76o5 31 &*7 79 52:7 13.LI le4.fj 71.1 67 30 29*3 22*g 72.5 50.1 13.4 17.1 67.7 5%3 26 27.7 20.0 & 13.3 lg.o 69.4 — 27.5 20.6 W 16.9 61.5 79.2 34*5 -- 25 t33.5 51.5 :.5 17.1 56 23.5 25-6 19.4 60.7 3J$.1 1!3.1 z:: 62.8 26.3 27.4 21 % z:; Ill*lb 10 *.4 39*3 -- -- 99.2 48.6 13.2 16.5 60 55.5 21.s 23*5 19.2 52.0 51 13@a 17.7 g.; 64.6 29 28.7 25.kb 72 54.5 J.4*5 lti.o 33.2 31 26 60.0

51*b 1305 M. 3 67.5 56.0 Q7 16.g 61.5 49.3 13 16.6 59* 5 53 2La 17.6 55.1

Ailingnaa

61.5 6 5095 $.4 16.9 6s. 1 24.3 19 52*9 U3.3 6&2 **9 16.4 63.9 4: 53.4 4.2 16 75*5 — * * 60 53 50.4 12.4 16.9 62.5 -- 30.7 2$6 75 81 52.4 15 16.5 83 30,1 63.5 —- —---- ●ExpOstxtin utero. .— 1963

Head Head Head Che s’t Subject Circ. , width s lengths Sitting circ.s Left calf Biacromial Bi-iliac Buttocks

NO. a a Ca ht., a Ca circ.$ a dia., rn dia., a Icirc., as —.—- —— --.— 2 53*7 14.7 18.9 65.3 62.0 25.5 20.7 63.0 51.6 13.4 18.0 62.8 70.3 26.7 2: 21.5 70.3 ? 49.5 13.6 17.4 60.3 59.0 23.6 24.0 18.8 59.3 15 52.0 13.7 17.7 81.8 ---- 31.4 30.4 6.0 83.8 17 52.8 13.9 18.4 73.7 ---- 28.0 29.8 20.3 73.0 19 51.5 14.3 17.4 p.o 66.0 27.0 29.7 22.4 72.o 20 55.1 15.8 18.0 79.2 31.1 ------81.0 21 52.3 14.1 17.7 72.0 K g.; 23.8 74.5 23 53.2 14.0 18.4 73.5 69.2 ;:: 24.0 74.0 32 50.0 13.5 17.2 68.7 63 27:2 28.0 20.4 65.3 33 51.7 13.3 18.2 74.5 50.9 [email protected] 28.4 21.2 68.5 ---- 36 53.0 15.2 17.2 87.3 79.0 34.5 27.2 85.0 42 51.8 14.5 17.1 70.3 57.0 24.8 25.4 21.4 64.0 47 57.0 15.0 ;;.: 89.1 79.8 34.5 ---- 26.8 :.; 52.7 14.2 69.1 ~.; 28.1 29.0 21.8 ,2; 49.7 13.5 16:6 65.0 . 22.9 23.6 ZO.o 62; 5 69 51.8 13.2 18.0 76.4 ---- 30.3 ---- 24.5 76.0 72 54.6 14.5 18.0 83.8 ---- 34.0 &.o 85.0

83* 51.7 13.4 18.3 87.5 59.5 26.7 26.2 19.1 62.5 85* 47.5 13.3 15.7 61.0 57.5 23.0 25.3 20.4 ~. 49.3 13.7 16.8 62.3 53.6 23.0 24.5 18.2 2:;

~ilingnae

6 50.9 14.4 17.1 67.2 61.3 25.0 26.1 19.2 65.0 53.0 lb.o 18.6 70.0 9.5 25.5 ti.1 20.8 4: 53.5 14.3 18.1 ---- 30.0 ---- 25.5 g:: 53. 50.0 13.5 17.0 E:; ---- 30.8 30.0 25.0 79.0

*Bxposed in utero. APPENDIX 17

Serum FolicAcid Levels~ 1963 — (normal = 7 to 20 wg/di borderline s 4 tO 7 ~g/rnl)

Subject Subject Subject No . n!.Lg/ml No. llwg/ml No. rqJg/lQl

2.2.2 72 10*5 *5 19.0 30.0 73 5.8 w 17.0 75 2.8 w 2;:: %: 1:.: 906 4.2 z 915 2.6 2.0.7 83 5:8 916 16.0 10.0 87 1.4 919 19.0 13.0 U.o 924 22.5 9.4 8;$ 16.o 926 IJ.. o 13.0 814 27.0 928 29.0 9.9 817 9.7 ;3 18.0 819 u. o ::: 8ZL ti.o w 37.0 3!:; 823 < 1*O 942 w 3*1 943 1{:: 22:0 825 22.0 w 5.4 826 8.2 M U:7 9.1 828 19.0 w 1.8.o 2L0 8* 950 14.0 I.1.o 830 ::? 953 1.2. o 833 <1.0 955 2:: 37.0 :$ 17.0 956 14.0 17.0 959 1;:: I&o 841 6.5 961 10.0 12.5 842 963 6.9 18.5 W+ i:; w 4.0 10.0 846 4.1 !%5 22.0 33*5 852 4.0 967 3*7 6.5 853 16.0 969 10.5 3.8 856 15.0 970 10.5 5.1 859 975 2.2 22.5 2;:; 99 LO.5 <1.0 ~ 25.0 993 37.0 8.2 13.0 996 61.5 4.7 867 17.0 H 14.0 868 9.5 1oo1 1.7 ;:; 876 <1.0 1005 1.2.o 12.0 882 14.0 1007 17.0 883 * 1.0 1035 1::; 15.0 W+ 3.1 1036 47.5 20.0 8a5 1.2.2 1041 15.0 U.o W6 7.6 10.0 M7 U?.3 25.0 8& 4.5 2.0.3 23.5

166 APPENDIX 18

Bone Marrow DifferentialCounts

Subject No.

4 63 68 73 948 1007

SEG P!4N - 9.8% 14.2X 15,o% 19.8% 16.8% 22.2%

SEC PMB 0.2 0.8 .-. --- 0.4 0.2

SEGm 0.6 1.8 2.6 2.8 2.2 0.4

BAND NEUT 10.6 6.4 6.6 10.0 5.8 10.6

BAND FASO --- -.. ------

BAiVDEOS 0.6 0.2 --- 0.6 0.4 0.2

L~ii NEm 16.2 6.4 11.8 13.2 9.8 18.8

NETA BASO .-. ... ------

METAEOS ------0.4 ------

M?EL. NEWT 10.0 4.6 9.8 7.2 5.2 7.0 --- .-. --- MTEL. BASO 0.4 ..- --- 1.0 MYEL. EOS 2.0 0.2 0.8 0.2 0.4

MYEImLAsT . . . --- 0.8 ------0.6

LYMPHOCYTE 18.0 33.0 14.8 21.2 27.0 16.4

--- LYMPHOBLAST 0.8 0.2 --- 0.2 0.2

0.8 MONOCTTE --- 0.2 0.6 0.2 0.6

-.. --- MONOBLAST ------.m- ---

NORMOBLMT ORTHC 18.0 23.2 24.2 21.0 21.6 17,0

NORMOBLASTBASO 8.2 5.8 5.4 2.0 5.0 2.8

ERTTHROBLAST 0.4 1.2 1,8 0.2 1.0 0.6

MKALOBLAST 1.6 --- 1.4 --- 0.8 0.6

PLASMA CELL 2.& 0.8 1.8 0.4 2.0 ~.~ --- R. E. CELL 0.6 1,6 O.h 1.0 0.2

—