DOCSLIB.ORG

Approved Supply List (Seventh Edition)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Approved Supply List (Seventh Edition) Approved Supply List (Seventh edition) Information approved for the classification and labelling of substances and preparations dangerous for supply Chemicals (Hazard Information and Packaging for Supply) Regulations 2002 APPROVED LIST L129 HSE BOOKS © Crown copyright 2002 Applications for reproduction should be made in writing to: Copyright Unit, Her Majesty’s Stationery Office, St Clements House, 2-1 6 Colegate, Norwich NR3 1 BQ First published 2002 ISBN 0 7176 23688 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means (electronic, mechanical, photocopying, recording or otherwise) without the prior written permission of the copyright owner. .. 11 Contents Notice of Approval v Preface vi Introduction vii Purpose of the Approved Supply List vii Structure of the Approved Supply List vii How to use the Approved Supply List vii Index number viii Conventions for alphabetical listing (Part of the List) viii Nomenclature ix Substance information in the ASL ix Groups of substances x Meaning of the notes used in Part I of the List x Labelling of preparations xii Partial and qualified entries: Notes H to R xii Note on the Approved Supply List xiii Part I Alphabetical listing, classification and labelling information 1 Part II Einecs and other descriptions of certain substances listed by Index number 358 Part III Mixtures of named substances or mixtures/specific isomers listed by Index Number 414 Part IV Information for classification of pesticides 427 Part V Sample entry, risk and safety phrases, hazard symbols and explanation of notes 432 iii 1. The Health and Safety Commission has on 16 April 2002 approved Notice of the publication of this document, Information approved for the approvaI classification and labelling of substances and preparations dangerous for supply (‘Approved Supply List (Seventh edition)’) for the purposes of the Chemicals (Hazard Information and Packaging for Supply) Regulations 2002 (‘CHIP 3’). 2. This Approved Supply List (Seventh edition) shall have effect from the date on which CHIP 3 comes into force. 3. On that date the Approved Supply List (Sixth edition) (approved by the Health and Safety Commission on 15 August 2000 for the purposes of the Chemicals (Hazard Information and Packaging for Supply) Regulations 1994 shall cease to have effect except insofar as is required by regulation 16 of CHIP 3. Signed Mark Dempsey Secretary to the Health and Safety Commission [15 May 2002] Previous page V is blank This Approved Supply List (Seventh edition) is based on Annex I to the Preface Dangerous Substances Directive (67/548/EEC) as adapted to technical progress. It incorporates all adaptations up to the 28th 1and supersedes the Approved Supply List (Sixth edition). The Chemicals (Hazard Information and Packaging for Supply) Regulations 2002 (CHIP 3) impose requirements by reference to this List and to that extent it is legally binding. The Approved Supply List (Seventh edition) is one of three documents supporting CHIP 3. The other two are: the Approved Classification and Labelling Guide and the Approved Code of Practice: The compilation of safety data sheets. ' Commission Directive 2001/59/EC (OJ L 225,21.8.2001, p.1). vi Issued: 2002 Approved Supply List (Seventh edition) vii Purpose of the Approved Supply List and which is updated from time to time by way of Adaptation to Technical Progress (ATP). This new edition of the ASL covers all ATPs up to the 28th. 1 The Approved SupplyList ('ASL' or 'the List' for short), is an integral part of the Chemicals (Hazard Information and 7 This edition of the ASL continues the arrangement Packaging for Supply) Regulations 2002 (CHIP). The introduced in the 4th edition of a single alphabetical listing Regulations define the system for classification and labelling which makes finding the entry for a substance a one-step of substances and preparations dangerous for supply. This operation. There are five parts to the ASL: system applies to all dangerous substances and preparations as defined in the Regulations and is based on Directives - Part I contains, and lists in alphabetical order of name, agreed by member states of the European Union - principally entries for all the substances covered; the Dangerous Substances Directive (67/548/EEC) and the Dangerous Preparations Directive (1999/45/EC), both as - Part I I reproduces the Einecs and other descriptions of amended and adapted to technical progress. certain substances to help identification in difficult cases; 2 The ASL has been approved by the Health and Safety Commission and contains detailed information about - Part III gives the names of all the substances covered by substances to assist manufacturers, importers and suppliers those entries which are applicable to mixtures of having responsibilities under CHIP. For the purposes of named substances or mixtures/specific isomers: classification and labelling, this comprises: - Part IV gives information for classification of (a) information to be shown on labels when the substance pesticides; and is supplied in packages; and - Part V summarises key information for users of the List (b) information to be used to derive the classification and supply labels for preparations containing the 8 In the course of producing a new edition of the ASL the substance. opportunity may be taken to correct typographical errors in earlier editions and as a result the entries for some 3 Inclusion of a substance in the ASL normally indicates substances may differ from those in the previous edition. that the substance is dangerous for supp1y. However, some Users should carefully check the entry for each substance of complex substances may have a partial or qualified entry, interest to them and ensure that they are using the correct meaning that the substance as supplied may not actually information. need to be labelled as dangerous. Great care should be taken in interpreting these entries (see paragraphs 27 to 31 for further details). On the other hand, the absence of a 9 The addition of new entries, or amendments to substance from the List does not imply that the substance is existing entries, in Annex I to the Dangerous Substances 'safe' In this case the person supp1ying the substance shou1d Directive is effected by referral of the necessary data to a assess the hazards and assign, as necessary, a classification Working Group of National Experts established under the and label in accordance with CHIP and the criteria in the Directive and chaired by representatives of the European Approved guide to the classification and labelling of commission. Any person seeking to add or amend Annex I substances and preparations dangerous for supply. entries should contact the Health and Safety Executive, Health Directorate, Chemical Supply Management Unit, 4 It is important to note that there is a difference Rose Court, 2 Southwark Bridge, London SEI 9HS (telephone between hazard (ie the inherent properties of a chemical) number: 0207-717 6000) to discuss the necessary data and and risk (ie the probability of the hazardous properties of procedure. More information on CHIP and its underlying EC the chemical causing harm to people or the environment). Directives, including news on recent developments, may be The ASL provides information about the hazards of certain found at: www.hse.gov.uk/hthdir/noframes/chip/chipo.htm substances, not the risk. How to use the Approved Supply List 5 Classification of a substance or preparation is important not only to derive the label for any package in 10 This paragraph explains how to use the ASL to find out which the substance is supplied, but also as a source of about the approved classification and labelling information in relation to control measures for handling, requirements for particular substances. use or storage, for example, under the Control of Substances Hazardous to Health Regulations 1999 (COSHH). The listing (a) First, turn to part I of the List and look for the entry for of any particular substance in the ASL however, does not the substance of interest. The entries are arranged in prejudice application of any prohibitions, controls, or alphabetical order of substance name. If you are special conditions laid down in any Act or regulation looking for one of the complex coal or oil derived relating to that substance. substances you will need to look under 'c' (for coal tar products) or 'p' (for petroleum substances); you may Structure of the Approved Supply List also need to refer to Part II (Einecs and other descriptions) to identify the correct entry. 6 The ASL is derived directly from Annex I to the Dangerous Substances Directive. Annex I is a list of dangerous substances for which harmonised classification and labelling have been agreed at Community level in accordance with the procedure laid down in the Directive viii Introduction Issued. 2002 Approved Supply List (Seventh edition) (b) , Once you have found the entry read off the - VW denotes the form in which the substance is substance classification (see paragraph 22(a)),label produced or placed on the market; and (see paragraph 22(b)) and concentration limit (see paragraph 22(c)) information as required, taking - Y is the checkdigit calculated in accordance with into account any notes accompanying the entry (see the ISBN (International Standard Book Number) also paragraphs 25 and 26). Refer to Part V and read method. off the full text of the risk and safety phrases as required. As an example, the Index number for sodium chlorate is 017-005-00-9. (c) Below the entry name you may see other names in smaller type. These will be either one or both of the Table 1 Index number classes for organic substances following: alternative names for the substance (see, for example, the entries for ethanol and ethyl alcohol), or the names of other substances with the same classification (see, for example, the entries for dimethylzinc and diethylzinc).
Load more

Recommended publications
  • Chemical Threat Agents Call Poison Control 24/7 for Treatment Information 1.800.222.1222 Blood Nerve Blister Pulmonary Metals Toxins
    CHEMICAL THREAT AGENTS CALL POISON CONTROL 24/7 FOR TREATMENT INFORMATION 1.800.222.1222 BLOOD NERVE BLISTER PULMONARY METALS TOXINS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS • Vertigo • Diarrhea, diaphoresis • Itching • Upper respiratory tract • Cough • Shock • Tachycardia • Urination • Erythema irritation • Metallic taste • Organ failure • Tachypnea • Miosis • Yellowish blisters • Rhinitis • CNS effects • Cyanosis • Bradycardia, bronchospasm • Flu-like symptoms • Coughing • Shortness of breath • Flu-like symptoms • Emesis • Delayed eye irritation • Choking • Flu-like symptoms • Nonspecific neurological • Lacrimation • Delayed pulmonary edema • Visual disturbances symptoms • Salivation, sweating INDICATIVE LAB TESTS INDICATIVE LAB TESTS INDICATIVE LAB TEST INDICATIVE LAB TESTS INDICATIVE LAB TESTS INDICATIVE LAB TESTS • Increased anion gap • Decreased cholinesterase • Thiodiglycol present in urine • Decreased pO2 • Proteinuria None Available • Metabolic acidosis • Increased anion gap • Decreased pCO2 • Renal assessment • Narrow pO2 difference • Metabolic acidosis • Arterial blood gas between arterial and venous • Chest radiography samples DEFINITIVE TEST DEFINITIVE TEST DEFINITIVE TEST DEFINITIVE TESTS DEFINITIVE TESTS • Blood cyanide levels • Urine nerve agent • Urine blister agent No definitive tests available • Blood metals panel • Urine ricinine metabolites metabolites • Urine metals panel • Urine abrine POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS • Hydrogen Cyanide
    [Show full text]
  • Theoretical Studies of Phenylmercury Carboxylates
    TA Theoretical studies of Phenylmercury 2750 carboxylates 2010 This page is intentionally left blank Theoretical studies of Phenylmercury carboxylates Complexation Constants and Gas Phase Photo- Oxidation of Phenylmercurycarboxylates. Yizhen Tang and Claus Jørgen Nielsen CTCC, Department of Chemistry, University of Oslo This page is intentionally left blank Table of Contents Executive Summary ................................................................................................................ 1 1. Quantum chemistry studies on phenylmercurycarboxylates ..................................... 3 2. Results from quantum chemistry ................................................................................... 3 2.1 Structure of phenylmercury(II) carboxylates .............................................................. 4 2.2 Energies of complexation/dissociation ....................................................................... 9 2.3 Vertical excitation energies......................................................................................... 10 2.4 Vertical ionization energies ......................................................................................... 11 2.5 Summary of results from quantum chemistry calculations .................................... 11 3. Atmospheric fate and lifetimes of phenylmercurycarboxylates ............................... 12 3.1 Literature data............................................................................................................... 12 3.2 Estimation of the
    [Show full text]
  • Stability of Dimethylmercury and Related Mercury-Containing Compounds with Respect to Selected Chemical Species Found in Aqueous Environment†
    CROATICA CHEMICA ACTA CCACAA, ISSN 0011-1643, e-ISSN 1334-417X Croat. Chem. Acta 86 (4) (2013) 453–462. http://dx.doi.org/10.5562/cca2314 Original Scientific Article Stability of Dimethylmercury and Related Mercury-containing Compounds † with Respect to Selected Chemical Species Found in Aqueous Environment Laimutis Bytautas Department of Chemistry, Rice University, Houston, Texas 77005, USA, Present address: Galveston College, Department of Chemistry, 4015 Avenue Q, Galveston, TX, 77550, USA. (E-mail: [email protected]) RECEIVED JUNE 23, 2013; REVISED OCTOBER 3, 2013; ACCEPTED OCTOBER 4, 2013 Abstract. Dimethylmercury (CH3−Hg−CH3) and other Hg-containing compounds can be found in atmos- pheric and aqueous environments. These substances are highly toxic and pose a serious environmental and health hazard. Therefore, the understanding of chemical processes that affect the stability of these sub- stances is of great interest. The mercury-containing compounds can be detected in atmosphere, as well as soil and aqueous environments where, in addition to water molecules, numerous ionic species are abun- dant. In this study we explore the stability of several small, Hg-containing compounds with respect to wa- + ter molecules, hydronium (H3O ) ions as well as other small molecules/ions using density functional theo- ry and wave function quantum chemistry methods. It is found that the stability of such molecules, most + notably of dimethylmercury, can be strongly affected by the presence of the hydronium H3O ions. Alt- hough the present theoretical study represents gas phase results, it implies that pH level of a solution should be a major factor in determining the degree of abundance for dimethylmercury in aqueous envi- + ronment.
    [Show full text]
  • Results of the Lake Michigan Mass Balance Study: Mercury Data Report
    Results of the Lake Michigan Mass Balance Study: Mercury Data Report February 2004 U.S. Environmental Protection Agency Great Lakes National Program Office (G-17J) 77 West Jackson Boulevard Chicago, IL 60604 EPA 905 R-01-012 Results of the Lake Michigan Mass Balance Study: Mercury Data Report Prepared for: US EPA Great Lakes National Program Office 77 West Jackson Boulevard Chicago, Illinois 60604 Prepared by: Harry B. McCarty, Ph.D., Ken Miller, Robert N. Brent, Ph.D., and Judy Schofield DynCorp (a CSC Company) 6101 Stevenson Avenue Alexandria, Virginia 22304 and Ronald Rossmann, Ph.D. US EPA Office of Research and Development Large Lakes Research Station 9311 Groh Road Grosse Ile, Michigan 48138 February 2004 Acknowledgments This report was prepared under the direction of Glenn Warren, Project Officer, USEPA Great Lakes National Program Office; and Louis Blume, Work Assignment Manager and Quality Assurance Officer, USEPA Great Lakes National Program Office (GLNPO). The report was prepared by Harry B. McCarty, Ken Miller, Robert N. Brent, and Judy Schofield, with DynCorp’s Science and Engineering Programs, and Ronald Rossmann, USEPA Large Lakes Research Station, with significant contributions from the LMMB Principal Investigators for mercury and Molly Middlebrook, of DynCorp. GLNPO thanks these investigators and their associates for their technical support in project development and implementation. Ronald Rossmann wishes to thank Theresa Uscinowicz for assistance with collection, preparation, and analysis of the samples; special thanks to staff of the NOAA Great Lakes Environmental Research Laboratory, University of Wisconsin-Milwaukee Great Lakes Water Institute Center for Great Lakes Studies, USEPA Great Lakes National Program, and USEPA Mid-Continent Ecology Division for collection of the samples.
    [Show full text]
  • Notes from Rao 2/13/2007 2:07:37 PM
    Environmental Assessment of Sediments and Water in Bayou Grande, Pensacola, FL. Dr. Carl J. Mohrherr Center for Environmental Diagnostics and Bioremediation University of West Florida Dr. Johan Liebens Department of Environmental Studies University of West Florida Dr. K. Ranga Rao Center for Environmental Diagnostics and Bioremediation University of West Florida June 26, 2008 FOREWORD This study is a component of the "Assessment of Environmental Pollution and Community Health in Northwest Florida" supported by a USEPA Cooperative Agreement award X-9745502 to The University of West Florida (Project Director: Dr. K. Ranga Rao). The contents of this report are solely the responsibility of the authors and do not necessarily represent the official views of the USEPA. The study was undertaken because of the increasing concern for environmental pollution and potential impacts on human health in Northwest Florida. It was designed to assess environmental impacts of toxic pollutants in Bayou Grande. Kristal Flanders managed the spatial databases for the project and drafted the maps. Her assistance has been invaluable. Chris Carlton-Franco, Brandon Jarvis, Guy Allard, and Danielle Peterson helped with the fieldwork and some laboratory procedures. Creative Commons License This work is licensed under a Creative Commons Attribution- NonCommercial- NoDerivatives 4.0 International License. i TABLE OF CONTENTS I INTRODUCTION........................................................................................................... 1 II STUDY AREA.............................................................................................................
    [Show full text]
  • Pyrophoric Materials
    Appendix A PYROPHORIC MATERIALS Pyrophoric materials react with air, or with moisture in air. Typical reactions which occur are oxidation and hydrolysis, and the heat generated by the reactions may ignite the chemical. In some cases, these reactions liberate flammable gases which makes ignition a certainty and explosion a real possibility. Examples of pyrophoric materials are shown below. (List may not be complete) (a) Pyrophoric alkyl metals and derivatives Groups Dodecacarbonyltetracobalt Silver sulphide Dialkytzincs Dodecacarbonyltriiron Sodium disulphide Diplumbanes Hexacarbonylchromium Sodium polysulphide Trialkylaluminiums Hexacarbonylmolybdenum Sodium sulphide Trialkylbismuths Hexacarbonyltungsten Tin (II) sulphide Nonacarbonyldiiron Tin (IV) sulphide Compounds Octacarbonyldicobalt Titanium (IV) sulphide Bis-dimethylstibinyl oxide Pentacarbonyliron Uranium (IV) sulphide Bis(dimethylthallium) acetylide Tetracarbonylnickel Butyllithium (e) Pyrophoric alkyl non-metals Diethylberyllium (c) Pyrophoric metals (finely divided state) Bis-(dibutylborino) acetylene Bis-dimethylarsinyl oxide Diethylcadmium Caesium Rubidium Bis-dimethylarsinyl sulphide Diethylmagnesium Calcium Sodium Bis-trimethylsilyl oxide Diethylzinc Cerium Tantalum Dibutyl-3-methyl-3-buten-1-Yniborane Diisopropylberyllium Chromium Thorium Diethoxydimethylsilane Dimethylberyllium Cobalt Titanium Diethylmethylphosphine Dimethylbismuth chloride Hafnium Uranium Ethyldimthylphosphine Dimethylcadmium Iridium Zirconium Tetraethyldiarsine Dimethylmagnesium Iron Tetramethyldiarsine
    [Show full text]
  • PROVISIONAL PEER REVIEWED TOXICITY VALUES for DIMETHYLMERCURY (CASRN 593-74-8) Derivation of Subchronic and Chronic Oral Rfds
    EPA/690/R-04/005F l Final 12-01-2004 Provisional Peer Reviewed Toxicity Values for Dimethylmercury (CASRN 593-74-8) Derivation of Subchronic and Chronic Oral RfDs Superfund Health Risk Technical Support Center National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati, OH 45268 Acronyms and Abbreviations bw body weight cc cubic centimeters CD Caesarean Delivered CERCLA Comprehensive Environmental Response, Compensation and Liability Act of 1980 CNS central nervous system cu.m cubic meter DWEL Drinking Water Equivalent Level FEL frank-effect level FIFRA Federal Insecticide, Fungicide, and Rodenticide Act g grams GI gastrointestinal HEC human equivalent concentration Hgb hemoglobin i.m. intramuscular i.p. intraperitoneal i.v. intravenous IRIS Integrated Risk Information System IUR inhalation unit risk kg kilogram L liter LEL lowest-effect level LOAEL lowest-observed-adverse-effect level LOAEL(ADJ) LOAEL adjusted to continuous exposure duration LOAEL(HEC) LOAEL adjusted for dosimetric differences across species to a human m meter MCL maximum contaminant level MCLG maximum contaminant level goal MF modifying factor mg milligram mg/kg milligrams per kilogram mg/L milligrams per liter MRL minimal risk level i MTD maximum tolerated dose MTL median threshold limit NAAQS National Ambient Air Quality Standards NOAEL no-observed-adverse-effect level NOAEL(ADJ) NOAEL adjusted to continuous exposure duration NOAEL(HEC) NOAEL adjusted for dosimetric differences across species to a
    [Show full text]
  • Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set
    MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2004/0266626A1 Schrof Et Al
    US 2004O26.6626A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0266626A1 Schrof et al. (43) Pub. Date: Dec. 30, 2004 (54) SOLID CROP PROTECTION Publication Classification FORMULATIONS AND DISPERSION FORMULATIONS AND THEIR USE IN (51) Int. Cl." ........................... A01N 25/10; AO1N 25/00 AGRICULTURE (52) U.S. Cl. ............................................ 504,361; 424/405 (76) Inventors: Wolfgang Schrof. Neuleiningen (DE); Robert Heger, Heidelberg (DE); (57) ABSTRACT Sebastian Koltzenburg, Dannstadt-Schauernheim (DE); Matthias Bratz, Limburgerhof (DE); The invention relates to a Solid crop protection formulation Cyrill Zagar, Mannheim (DE); Dieter comprising Horn, Heidelberg (DE) a) at least one crop protection agent Selected from the Correspondence Address: group consisting of herbicides, pesticides and fun KEIL & WEINKAUF gicides, with the proviso that cinidon-ethyl is not 1350 CONNECTICUT AVENUE, N.W. included; WASHINGTON, DC 20036 (US) b) at least one random radical copolymer comprising as (21) Appl. No.: 10/494,766 polymerized units at least one hydrophilic and at least one hydrophobic monomer; and (22) PCT Filed: Nov. 6, 2002 c) optionally further additives, (86) PCT No.: PCT/EPO2/12399 wherein at least 50% of the dispersed particles of the at least Related U.S. Application Data one crop protection agent in Said Solid crop protection formulation are in an X-ray amorphous State. Additionally, (60) Provisional application No. 60/331,058, filed on Nov. the invention relates to processes for preparing Said formu 7, 2001. lations and the use of Said formulations in agriculture. US 2004/0266626 A1 Dec. 30, 2004 SOLID CROP PROTECTION FORMULATIONS agglomeration in a particle size of nanometers.
    [Show full text]
  • Date: 1/9/2017 Question: Botulism Is an Uncommon Disorder Caused By
    6728 Old McLean Village Drive, McLean, VA 22101 Tel: 571.488.6000 Fax: 703.556.8729 www.clintox.org Date: 1/9/2017 Question: Botulism is an uncommon disorder caused by toxins produced by Clostridium botulinum. Seven subtypes of botulinum toxin exist (subtypes A, B, C, D, E, F and G). Which subtypes have been noted to cause human disease and which ones have been reported to cause infant botulism specifically in the United States? Answer: According to the cited reference “Only subtypes A, B, E and F cause disease in humans, and almost all cases of infant botulism in the United States are caused by subtypes A and B. Botulinum-like toxins E and F are produced by Clostridium baratii and Clostridium butyricum and are only rarely implicated in infant botulism” (Rosow RK and Strober JB. Infant botulism: Review and clinical update. 2015 Pediatr Neurol 52: 487-492) Date: 1/10/2017 Question: A variety of clinical forms of botulism have been recognized. These include wound botulism, food borne botulism, and infant botulism. What is the most common form of botulism reported in the United States? Answer: According to the cited reference, “In the United States, infant botulism is by far the most common form [of botulism], constituting approximately 65% of reported botulism cases per year. Outside the United States, infant botulism is less common.” (Rosow RK and Strober JB. Infant botulism: Review and clinical update. 2015 Pediatr Neurol 52: 487-492) Date: 1/11/2017 Question: Which foodborne pathogen accounts for approximately 20 percent of bacterial meningitis in individuals older than 60 years of age and has been associated with unpasteurized milk and soft cheese ingestion? Answer: According to the cited reference, “Listeria monocytogenes, a gram-positive rod, is a foodborne pathogen with a tropism for the central nervous system.
    [Show full text]
  • High Hazard Chemical Policy
    Environmental Health & Safety Policy Manual Issue Date: 2/23/2011 Policy # EHS-200.09 High Hazard Chemical Policy 1.0 PURPOSE: To minimize hazardous exposures to high hazard chemicals which include select carcinogens, reproductive/developmental toxins, chemicals that have a high degree of toxicity. 2.0 SCOPE: The procedures provide guidance to all LSUHSC personnel who work with high hazard chemicals. 3.0 REPONSIBILITIES: 3.1 Environmental Health and Safety (EH&S) shall: • Provide technical assistance with the proper handling and safe disposal of high hazard chemicals. • Maintain a list of high hazard chemicals used at LSUHSC, see Appendix A. • Conduct exposure assessments and evaluate exposure control measures as necessary. Maintain employee exposure records. • Provide emergency response for chemical spills. 3.2 Principle Investigator (PI) /Supervisor shall: • Develop and implement a laboratory specific standard operation plan for high hazard chemical use per OSHA 29CFR 1910.1450 (e)(3)(i); Occupational Exposure to Hazardous Chemicals in Laboratories. • Notify EH&S of the addition of a high hazard chemical not previously used in the laboratory. • Ensure personnel are trained on specific chemical hazards present in the lab. • Maintain Material Safety Data Sheets (MSDS) for all chemicals, either on the computer hard drive or in hard copy. • Coordinate the provision of medical examinations, exposure monitoring and recordkeeping as required. 3.3 Employees: • Complete all necessary training before performing any work. • Observe all safety
    [Show full text]
  • Method 3200: Mercury Species Fractionation and Quantification By
    METHOD 3200 MERCURY SPECIES FRACTIONATION AND QUANTIFICATION BY MICROWAVE ASSISTED EXTRACTION, SELECTIVE SOLVENT EXTRACTION AND/OR SOLID PHASE EXTRACTION SW-846 is not intended to be an analytical training manual. Therefore, method procedures are written based on the assumption that they will be performed by analysts who are formally trained in at least the basic principles of chemical analysis and in the use of the subject technology. In addition, SW-846 methods, with the exception of required method use for the analysis of method-defined parameters, are intended to be guidance methods which contain general information on how to perform an analytical procedure or technique which a laboratory can use as a basic starting point for generating its own detailed standard operating procedure (SOP), either for its own general use or for a specific project application. The performance data included in this method are for guidance purposes only, and are not intended to be and must not be used as absolute QC acceptance criteria for purposes of laboratory accreditation. 1.0 SCOPE AND APPLICATION For a summary of changes in this version from the previous version, please see Appendix A at the end of this document. 1.1 This method contains a sequential extraction and separation procedure that may be used in conjunction with a determinative method to differentiate mercury species that are present in soils and sediments. This method provides information on both total mercury and various mercury species. 1.2 The speciation of a metal, in this case mercury, involves determining the actual form of the molecules or ions that are present in the sample.
    [Show full text]