DOCSLIB.ORG

2014 SPR Postgraduate Course SAM 1

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
2014 SPR Postgraduate Course SAM 1 SAM 1: Concerning secretin, what is 2014 SPR Postgraduate true? Course A. Administered as a bolus B. Contraindicated in cholelithiasis Module 3: Gastrointestinal C. Relaxes the sphincter of Oddi Moderators: Kassa Darge, MD/PhD and Jonathan Dillman, MD D. Causes gallbladder contraction Washington DC E. Stimulates bicarbonate secretion 2014 SPR PG Course 2014 SPR PG Course Concerning secretin, what is true? SAM 2: What feature of chronic pancreatitis is seen in this secretin MRCP? • A) is NOT correct – secretin must be slowly References A. Parenchymal calcification administered over one minute to avoid • Tirkes T, Sandrasegaran K, Sanyal R, Sherman abdominal pain and vomiting S, Schmidt CM, Cote GA, Akisik F. Secretin- B. Peripancreatic fluid collection • B) is NOT correct – the only relative enhanced MR cholangiopancreatography: contraindication to secretin use is acute spectrum of findings. Radiographics. 2013 Nov- C. Pancreatic parenchymal pancreatitis Dec;33(7):1889-906 edema • C) is NOT correct – secretin causes a transient • Tirkes T, Menias CO, Sandrasegaran K. MR increase in tone at the sphincter of Oddi which imaging techniques for pancreas. Radiol Clin D. Side branch dilation partly accounts for duct dilation North Am. 2012 May;50(3):379-93. • D) is NOT correct – secretin has no effect on • Delaney L, Applegate KE, Karmazyn B, Akisik E. Pancreatic duct stone gallbladder contraction MF, Jennings SG. MR • E) is correct – secretin stimulates cholangiopancreatography in children: bicarbonate secretion which, combined with feasibility, safety, and initial experience. Pediatr increased tone at the sphincter of Oddi Radiol. 2008 Jan;38(1):64-75. causes pancreatic duct dilation 1 SAM 3: 5 year old with pancreatitis. What is the most What feature of chronic pancreatitis is likely diagnosis and etiology of the pancreatitis? seen in this secretin MRCP? • A) is NOT correct – calcifications are not References A. Pancreas divisum visible • Tirkes T, Sandrasegaran K, Sanyal R, • B) is NOT correct – peripancreatic fluid Sherman S, Schmidt CM, Cote GA, Akisik F. B. Chronic pancreatitis collections are a finding of acute pancreatitis Secretin-enhanced MR and are not seen in this case cholangiopancreatography: spectrum of C. Choledochal Cyst Type • C) is NOT correct – parenchymal edema is a findings. Radiographics. 2013 Nov- finding of acute pancreatitis and is not seen Dec;33(7):1889-906 4a in this case • Tirkes T, Menias CO, Sandrasegaran K. MR • D) is correct – dilated side branches are imaging techniques for pancreas. Radiol Clin D. Choledocholithiasis visible in the head and body of the North Am. 2012 May;50(3):379-93. pancreas • E) is NOT correct – there is no filling defect in the pancreatic duct to suggest the presence of a pancreatic duct stone 5 year old with pancreatitis. What is the most 5 year old with pancreatitis. What is the most likely diagnosis and etiology of the pancreatitis likely diagnosis and etiology of the pancreatitis based on the image? based on the image? Answer- Choice C is correct: The 3D reconstruction Figure B Choice D is not correct as well. There would be filling defects representing stones but there are no stones or debris from MRCP shows dilated intra and extrahepatic ducts in the ducts. No gallstones either. Keep in mind though bile stasis predisposes patients to develop sludge and which qualify as a Type 4A choldedochal cyst according stones in the bile ducts. to the Todani classification. There is mass effect on the pancreatic duct which is not uncommon and results in backwash of pancreatic fluid resulting in pancreatitis. References: Choice A is not correct as the pancreatic duct and CBD do • Mortele KF, Rocha T et al Multimodality Imaging of Pancreatic and Biliary Congenital Anomalies, Radiographics not separately insert, the definition of pancreas divisum. 2006 • Egbert ND, Bloom DA, Dillman JR. Magnetic resonance imaging of the pediatric pancreaticobiliary system. Choice B is not correct. A child with chronic pancreatitis will Magn Reson Imaging Clin N Am. 2013 Nov;21(4):681-96. have multiple episodes of pancreatitis in the past with a very • Rizzo RJ, Szucs RA et al. Congenital Abnormalities of the Pancreas and Biliary Tree in Adults abnormal appearing duct with undulations, irregularities, Chronic pancreatitis strictures and opacification of side branches (see Figure B). Ductal dilatation 2 SAM 4: Boy with Crohn’s disease Boy with Crohn’s disease and new buttock pain. What is the and new buttock pain. What is the diagnosis? diagnosis? • Answer is B. Intersphincteric Abscess References • Rationales: The images show a peripherally- • Hammer MR, Dillman JR, Smith EA, Al- enhancing fluid collection located in the Hawary MM. Magnetic resonance imaging intersphincteric space, consistent with an of perianal and perineal Crohn disease in intersphincteric abscess. Such abscesses that children and adolescents. Magn Reson A. Skin Tag cross the midline are sometimes referred to as “horseshoe” abscesses. Imaging Clin N Am. 2013 Nov;21(4):813- B. Intersphincteric Abscess 28. • A supralevator abscess would be located above C. Transphincteric Fistula the levator ani musculature. Transphincteric • O'Malley RB, Al-Hawary MM, Kaza RK, fistulas are linear tracts that traverse both the Wasnik AP, Liu PS, Hussain HK. Rectal D. Extrasphincteric Fistula internal and external anal sphincter muscles, while imaging: part 2, Perianal fistula evaluation extrasphincteric fistulas extend from the high on pelvic MRI--what the radiologist needs E. Supralevator Abscess perirectal region through the levator ani to know. AJR Am J Roentgenol. 2012 musculature into the ischioanal fossa. Skin tags Jul;199(1):W43-53. appear as enhancing lobular polypoidal growths arising from the perianal skin surface. SAM 5: 9 year old with failure to thrive and coffee SAM 5: 9 year old with failure to thrive and ground emesis. Touch the abnormality. coffee ground emesis. Touch the abnormality 2014 SPR PG Course 3 SAM 6: What is the abnormality in this 9 year old with failure to thrive and coffee ground emesis? 9 year old with failure to thrive and coffee ground emesis. What is the abnormality? A.Pancreas divisum • Answer-Correct Choice D Annular Pancreas: This spot image from the upper GI demonstrates an incomplete obstruction in the second portion of the duodenum. The basis of annular pancreas is B.Pancreatitis duodenal stenosis/obstruction. In the largest series to date, all children presented with duodenal obstruction (Zyromski et al), not pancreatitis as was once thought. There is also a higher association with other congenital anomalies. Embryologically there is an error in rotation and fusion of the pancreas C.Choledochal Cyst during the 4-9th weeks of gestation. The ventral pancreatic bud fuses to the duodenum –this then results in abnormal rotation of the ventral bud during the fusion with the dorsal analge. Eventually there D.Annular Pancreas is a partial or complete ring of pancreatic tissue around the second portion of the duodenum with or without inclusion of the pancreatic duct. 2014 SPR PG Course 9 year old with failure to thrive and coffee ground SAM 7: 6-year-old male. Which is the most emesis. What is the abnormality? likely mechanism of injury? • Choice A is not correct as there is no bowel obstruction References associated with pancreas divisum. In fact the diagnosis • Mortele KF, Rocha T et al Multimodality A. Penetrating laceration can be made on MRCP not on upper GI examination. Imaging of Pancreatic and Biliary Congenital • Choice B is not correct and this diagnosis cannot be Anomalies, Radiographics 2006 B. Blunt injury from bicycle made based on this modality, but is best identified on US, • Egbert ND, Bloom DA, Dillman JR. handlebar MRI or CT. Pancreatitis alone will result in edema, Magnetic resonance imaging of the pediatric enlargement of the pancreas with mild dilatation of the pancreaticobiliary system. Magn Reson C. Diving into a shallow pool pancreatic duct with or without pancreatic fluid collections. Imaging Clin N Am. 2013 Nov;21(4):681-96. There is no associated duodenal obstruction with • Rizzo RJ, Szucs RA et al. Congenital D. Flank injury from karate kick pancreatitis Abnormalities of the Pancreas and Biliary • Choice C is not correct. Choledochal cysts are a form of Tree in Adults ductal ectasia and can result in mass effect on the head of the pancreas or result in upstream intrahepatic ductal dilatation, but they do not result in duodenal narrowing or obstruction. 4 SAM 8: 12 year-old-male with upper abdominal 6-year-old male. Which is the most likely trauma. What is most suggestive of a pancreatic mechanism of injury? ductal injury? A. Non-visualization of the pancreatic duct • The answer is “B”. Blunt injury References: B. Free fluid in the pelvis from bicycle handlebar. • Lam JPH et al. Delayed presentation • Rationales: Bicycle accidents account of handlebar injuries in children. BMJ. C. Peripancreatic fluid collection for 5-14% of blunt abdominal trauma 2001 May26; 322(7297): 1288-1289. in children, and handlebar injuries • Gross JA et al. Handlebar Injury D. Free intraperitoneal air visualized account for 27% of blunt pancreatic Causing Pancreatic Contusion in a by ultrasound trauma in children. All other listed Pediatric Patient. Am J Roentgenol, mechanisms of pancreatic injury 2002; 179;222 would be substantially less likely to cause a pancreatic laceration. SAM: 12 year-old-male with upper abdominal trauma. SAM 9: What would suggest a predominantly Which of the following is most suggestive of a fibrotic stricture? pancreatic ductal injury? • The answer is “C”. Peripancreatic fluid collection References: A. Luminal narrowing • Rationale: Peripancreatic fluid collections in the • Sivit CJ et al. Imaging Children with setting of suspected pancreatic trauma are Abdominal TraumaAJR May 2009, B. Proximal bowel dilation suggestive of pancreatic ductal injury. Approximately Volume 192, Number 5 one half of focal fluid collections that develop after C. Hyperintense T2W signal in the pancreatic injury evolve into pseudocysts., and • Ruess L, Sivit CJ, Eichelberger MR, approximately one half of pseudocysts resolve Gotschall CS, Taylor GA.
Load more

Recommended publications
  • Rectal Indomethacin Or I.V. Gabexate Mesylate As Prophylaxis for AP ERCP
    European Review for Medical and Pharmacological Sciences 2017; 21: 5268-5274 Rectal indomethacin or intravenous gabexate mesylate as prophylaxis for acute pancreatitis post-endoscopic retrograde cholangiopancreatography V. GUGLIELMI, M. TUTINO, V. GUERRA, P. GIORGIO National Institute of Gastroenterology, “S. de Bellis” Research Hospital Castellana Grotte, Bari, Italy Abstract. – OBJECTIVE: We aimed to evaluate mechanisms of AP are obstruction of the com- the results in our case series of AP ERCP over mon bile duct by stones, and alcohol abuse. En- the last three years. The prophylaxis for acute doscopic retrograde cholangiopancreatography pancreatitis (AP) post-endoscopic retrograde (ERCP) is the most frequent iatrogenic cause. cholangiopancreatography (ERCP) consists of rectal indomethacin, but some studies are not Post-ERCP AP is the most common and fear concordant. some adverse event for this procedure. In the PATIENTS AND METHODS: We compared 241 United States this complication costs $150 mil- ERCP performed from January 2014 to February lion annually for American Healthcare2,3 and it 2015 with intravenous gabexate mesylate (Group is a common cause of endoscopy-related lawsu- A), with the 387 ERCP performed from March its against gastroenterologists in the world. It 2015 to December 2016 with rectal indometha- has a significant morbidity and rare mortality cin (Group B) as prophylaxis for AP post-ERCP. RESULTS: There were 8 (3.31%) AP post-ERCP rate. About 10% of post-ERCP AP is moderate in Group A vs. 4 (1.03%) in Group B. or severe. Post-ERCP severe AP is associated CONCLUSIONS: Rectal indomethacin shows a with a higher mortality than non-ERCP-indu- better statistically significant performance than ced pancreatitis, but without statistical eviden- intravenous gabexate mesylate in the prophylax- ce4.
    [Show full text]
  • Frey Operation for Chronic Pancreatitis Associated with Pancreas Divisum: Case Report and Review of the Literature
    Case report Frey operation for chronic pancreatitis associated with pancreas divisum: case report and review of the literature Magdalena Skórzewska1, Tomasz Romanowicz2, Jerzy Mielko1, Andrzej Kurylcio1, Jan Pertkiewicz3, Robert Zymon2, Wojciech P. Polkowski1 1Department of Surgical Oncology, Medical University of Lublin, Poland 2Department of General and Oncological Surgery, Pope John Paul II Regional Hospital, Zamosc, Poland 3Olympus Endotherapy, Warsaw, Poland Prz Gastroenterol 2014; 9 (3): 175–178 DOI: 10.5114/pg.2014.43581 Key words: pancreas divisum, chronic pancreatitis, surgery. Address for correspondence: Prof. Wojciech P. Polkowski MD, PhD, Department of Surgical Oncology, Medical University of Lublin, 11 Staszica St, 20-081 Lublin, Poland, phone: +48 81 534 43 13, fax: +48 81 532 23 95, e-mail: [email protected] Abstract Pancreas divisum (PD) is the most common congenital anomaly of the pancreas, which increases susceptibility to recurrent pancreatitis. Usually, after failure of initial endoscopic therapies, surgical treatment combining pancreatic resection or drainage is used. The Frey procedure is used for chronic pancreatitis, but it has not been reported to be applied in an adult patient with PD-associated pancreatitis. The purpose of the paper was to describe effective treatment of this rare condition by the Frey procedure after failure of interventional endoscopic treatment. A 39-year-old female patient was initially treated for recurrent acute pancreatitis. After endoscopic diagnosis of PD, the minor duodenal papilla was incised and a plastic stent was inserted into the dorsal pancreatic duct. During the following 36 months, the patient was hospitalised several times because of recur- rent episodes of pancreatitis. Thereafter, local resection of the pancreatic head combined with lateral pancreaticojejunostomy was performed with no complications.
    [Show full text]
  • A Gastric Duplication Cyst with an Accessory Pancreatic Lobe
    Turk J Gastroenterol 2014; 25 (Suppl.-1): 199-202 An unusual cause of recurrent pancreatitis: A gastric duplication cyst with an accessory pancreatic lobe xxxxxxxxxxxxxxx Aysel Türkvatan1, Ayşe Erden2, Mehmet Akif Türkoğlu3, Erdal Birol Bostancı3, Selçuk Dişibeyaz4, Erkan Parlak4 1Department of Radiology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey 2Department of Radiology, Ankara University Faculty of Medicine, Ankara, Turkey 3Department of Gastroenterological Surgery, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey 4Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey ABSTRACT Congenital anomalies of pancreas and its ductal drainage are uncommon but in general surgically correctable causes of recurrent pancreatitis. A gastric duplication cyst communicated with an accessory pancreatic lobe is an extremely rare cause of recurrent pancreatitis, but an early and accurate diagnosis of this anomaly is important because suitable surgical treatment may lead to a satisfactory outcome. Herein, we presented multidetector com- puted tomography and magnetic resonance imaging findings of a gastric duplication cyst communicating with an accessory pancreatic lobe via an aberrant duct in a 29-year-old woman with recurrent acute pancreatitis and also reviewed other similar cases reported in the literature. Keywords: Aberrant pancreatic duct, accessory pancreatic lobe, acute pancreatitis, gastric duplication cyst, multi- detector computed tomography, magnetic resonance imaging INTRODUCTION Herein, we presented multidetector CT and MRI find- Report Case Congenital causes of recurrent pancreatitis include ings of a gastric duplication cyst communicating with anomalies of the biliary or pancreatic ducts, espe- an accessory pancreatic lobe via an aberrant duct in a cially pancreas divisum. A gastric duplication cyst 29-year-old woman with recurrent acute pancreatitis communicating with an aberrant pancreatic duct is and also reviewed other similar cases reported in the an extremely rare but curable cause of recurrent pan- literature.
    [Show full text]
  • Intraductal Papillary Mucinous Carcinoma of The
    Nishi et al. BMC Gastroenterology (2015) 15:78 DOI 10.1186/s12876-015-0313-3 CASE REPORT Open Access Intraductal papillary mucinous carcinoma of the pancreas associated with pancreas divisum: a case report and review of the literature Takeshi Nishi1,2*, Yasunari Kawabata2, Noriyoshi Ishikawa3, Asuka Araki3, Seiji Yano2, Riruke Maruyama3 and Yoshitsugu Tajima2 Abstract Background: Pancreas divisum, the most common congenital anomaly of the pancreas, is caused by failure of the fusion of the ventral and dorsal pancreatic duct systems during embryological development. Although various pancreatic tumors can occur in patients with pancreas divisum, intraductal papillary mucinous neoplasm is rare. Case presentation: A 77-year-old woman was referred to our hospital because she was incidentally found to have a cystic tumor in her pancreas at a regular health checkup. Contrast-enhanced abdominal computed tomography images demonstrated a cystic tumor in the head of the pancreas measuring 40 mm in diameter with slightly enhancing mural nodules within the cyst. Endoscopic retrograde pancreatography via the major duodenal papilla revealed a cystic tumor and a slightly dilated main pancreaticductwithanabruptinterruptionattheheadofthe pancreas. The orifice of the major duodenal papilla was remarkably dilated and filled with an abundant extrusion of mucin, and the diagnosis based on pancreatic juice cytology was “highly suspicious for adenocarcinoma”. Magnetic resonance cholangiopancreatography depicted a normal, non-dilated dorsal pancreatic duct throughout the pancreas. The patient underwent a pylorus-preserving pancreaticoduodenectomy under the diagnosis of intraductal papillary mucinous neoplasm with suspicion of malignancy arising in the ventral part of the pancreas divisum. A pancreatography via the major and minor duodenal papillae on the surgical specimen revealed that the ventral and dorsal pancreatic ducts were not connected, and the tumor originated in the ventral duct, i.e., the Wirsung’s duct.
    [Show full text]
  • Albany Med Conditions and Treatments
    Albany Med Conditions Revised 3/28/2018 and Treatments - Pediatric Pediatric Allergy and Immunology Conditions Treated Services Offered Visit Web Page Allergic rhinitis Allergen immunotherapy Anaphylaxis Bee sting testing Asthma Drug allergy testing Bee/venom sensitivity Drug desensitization Chronic sinusitis Environmental allergen skin testing Contact dermatitis Exhaled nitric oxide measurement Drug allergies Food skin testing Eczema Immunoglobulin therapy management Eosinophilic esophagitis Latex skin testing Food allergies Local anesthetic skin testing Non-HIV immune deficiency disorders Nasal endoscopy Urticaria/angioedema Newborn immune screening evaluation Oral food and drug challenges Other specialty drug testing Patch testing Penicillin skin testing Pulmonary function testing Pediatric Bariatric Surgery Conditions Treated Services Offered Visit Web Page Diabetes Gastric restrictive procedures Heart disease risk Laparoscopic surgery Hypertension Malabsorptive procedures Restrictions in physical activities, such as walking Open surgery Sleep apnea Pre-assesment Pediatric Cardiothoracic Surgery Conditions Treated Services Offered Visit Web Page Aortic valve stenosis Atrial septal defect repair Atrial septal defect (ASD Cardiac catheterization Cardiomyopathies Coarctation of the aorta repair Coarctation of the aorta Congenital heart surgery Congenital obstructed vessels and valves Fetal echocardiography Fetal dysrhythmias Hypoplastic left heart repair Patent ductus arteriosus Patent ductus arteriosus ligation Pulmonary artery stenosis
    [Show full text]
  • Pancreas Divisum: Evaluation and Treatment of a Persistently Controversial Anatomic Finding
    FRONTIERS IN ENDOSCOPY, SERIES #61 FRONTIERS IN ENDOSCOPY, SERIES #61 Douglas G. Adler MD, FACG, AGAF, FASGE, Series Editor Pancreas Divisum: Evaluation and Treatment of a Persistently Controversial Anatomic Finding Taylor Frost Douglas G. Adler INTRODUCTION ancreas divisum (literally, “divided pancreas”) condition.1 CFTR mutations may be present in is the most common anatomic variant of the up to 22% of patients with pancreas divisum who pancreas and is thought to exist in 5-10% of develop pancreatitis.2 P 36,37 the population. Pancreas divisum is the result of The majority of patients with pancreas divisum the failed fusion of the dorsal and ventral pancreatic will remain clinically asymptomatic and may buds early in development, resulting in the majority only be diagnosed incidentally in the context of of the pancreas being drained through the minor an imaging study ordered for another indication. papilla. (Figure 1) In patients with normal anatomy, However, some patients may be found to have the majority of the pancreas drains through the pancreas divisum in the setting of a history of, major papilla. More formally stated, in patients or investigation into, episodes of pancreatitis.3 It with pancreas divisum, the variant pancreatic has been proposed that a relatively stenotic minor ductal anatomy leads to the relatively large dorsal papilla may predispose patients with pancreas pancreas segment being drained through the minor divisum to recurrent episodes of pancreatitis.15 As papilla while the smaller ventral bud drains through such, in some cases patients are recommended to the major papilla. There is no known etiology undergo therapy for pancreas divisum, usually in the for pancreas divisum however, some genetic form of endoscopic minor papilla sphincterotomy abnormalities including mutations in the Cystic and/or endoscopic pancreatic duct stenting and, Fibrosis Transmembrane Conductance Regulator rarely, via surgical intervention.
    [Show full text]
  • Carcinoid Tumor of the Minor Papilla in Complete Pancreas Divisum Presenting As Recurrent Abdominal Pain Yong Gil Kim, Tae Nyeun Kim*, Kyeong Ok Kim
    Kim et al. BMC Gastroenterology 2010, 10:17 http://www.biomedcentral.com/1471-230X/10/17 CASE REPORT Open Access Carcinoid tumor of the minor papilla in complete pancreas divisum presenting as recurrent abdominal pain Yong Gil Kim, Tae Nyeun Kim*, Kyeong Ok Kim Abstract Background: Tumors of the minor papilla of the duodenum are extremely rare, and they are mostly neuroendocrine tumors, such as somatostatinomas and carcinoid tumors. However, true incidence of carcinoid tumors in minor papilla might be much higher, because patients with minor papillary tumors usually remain asymptomatic. We report a very unusual case of carcinoid tumor in a patient with complete pancreas divisum with a review of the literature. Case presentation: A 56-year-old female patient was referred for evaluation of pancreatic duct dilatation noted on abdominal ultrasonography and computerized tomography. She complained of intermittent epigastric pain for 6 months. A MRCP and ERCP revealed complete pancreas divisum with dilatation of the main pancreatic duct. On duodenoscopy, a small, yellows, subepithelial nodule was visualized at the minor papilla; biopsy of this lesion revealed a carcinoid tumor. She underwent a pylorus-preserving pancreaticoduodenectomy. The histologic evaluation showed a single nodule, 1 cm in diameter, in the submucosa with duodenal and vascular invasion and metastasis to the regional lymph nodes. Conclusion: Although the size of the carcinoid tumor was small and the tumor was hormonally inactive, the concomitant pancreas divisum led to an early diagnosis, the tumor had aggressive behavior. Carcinoid tumors of the minor papilla should be included in the differential diagnosis of recurrent abdominal pain or pancreatitis of unknown cause.
    [Show full text]
  • Diagnosis and Treatment of Pancreas Divisum: a Literature Review
    Hepatobiliary & Pancreatic Diseases International 18 (2019) 332–336 Contents lists available at ScienceDirect Hepatobiliary & Pancreatic Diseases International journal homepage: www.elsevier.com/locate/hbpd Review Article Diagnosis and treatment of pancreas divisum: A literature review ∗ Valentina Ferri , Emilio Vicente, Yolanda Quijano, Benedetto Ielpo, Hipolito Duran, Eduardo Diaz, Isabel Fabra, Riccardo Caruso Division of General Surgery, Sanchinarro Hospital, San Pablo University, calle oña 10, 28050 Madrid, Spain a r t i c l e i n f o a b s t r a c t Article history: Background: Pancreas divisum is a congenital embryological disease caused by a lack of fusion between Received 3 October 2018 the ventral and dorsal pancreatic ducts in the early stages of embryogenesis. Recurrent acute pancreatitis, Accepted 13 May 2019 chronic pancreatitis or chronic abdominal pain are the main clinical syndromes at presentation and occur Available online 20 May 2019 in only 5% of the patients with pancreas divisum. This review aimed to discuss diagnosis and treatment Keywords: strategies in patients with symptomatic pancreas divisum. Pancreas divisum Data sources: We report a literature review from 1990 up to January 2018 to explore the various di- Duodenal-preserving pancreatectomy agnostic modalities and surgical techniques and results reported in the surgical treatment of pancreas Chronic pancreatitis divisum. Recurrent acute pancreatitis Results: There are limited reports available on this topic in the literature. We analyzed and described the main indications in the treatment of pancreas divisum, focusing on surgical treatment and a discussion of the different approaches. Furthermore, we report the results from our experience in two cases of pancreas divisum treated by pancreatic head resection with segmental duodenectomy (the Nakao procedure).
    [Show full text]
  • Statistical Analysis Plan
    Cover Page for Statistical Analysis Plan Sponsor name: Novo Nordisk A/S NCT number NCT03061214 Sponsor trial ID: NN9535-4114 Official title of study: SUSTAINTM CHINA - Efficacy and safety of semaglutide once-weekly versus sitagliptin once-daily as add-on to metformin in subjects with type 2 diabetes Document date: 22 August 2019 Semaglutide s.c (Ozempic®) Date: 22 August 2019 Novo Nordisk Trial ID: NN9535-4114 Version: 1.0 CONFIDENTIAL Clinical Trial Report Status: Final Appendix 16.1.9 16.1.9 Documentation of statistical methods List of contents Statistical analysis plan...................................................................................................................... /LQN Statistical documentation................................................................................................................... /LQN Redacted VWDWLVWLFDODQDO\VLVSODQ Includes redaction of personal identifiable information only. Statistical Analysis Plan Date: 28 May 2019 Novo Nordisk Trial ID: NN9535-4114 Version: 1.0 CONFIDENTIAL UTN:U1111-1149-0432 Status: Final EudraCT No.:NA Page: 1 of 30 Statistical Analysis Plan Trial ID: NN9535-4114 Efficacy and safety of semaglutide once-weekly versus sitagliptin once-daily as add-on to metformin in subjects with type 2 diabetes Author Biostatistics Semaglutide s.c. This confidential document is the property of Novo Nordisk. No unpublished information contained herein may be disclosed without prior written approval from Novo Nordisk. Access to this document must be restricted to relevant parties.This
    [Show full text]
  • Pancreas Divisum : an Infrequent Cause of Acute Pancreatitis
    Pancreas Divisum : An Infrequent cause of Acute Pancreatitis Introduction:Pancreatic divisum (PD) is a condition that develops if the embryonic fusion of the dorsal and the ventral pancreas buds at the gestational age of 6 weeks is incomplete. The failure of fusion between these two pancreatic ducts results in a short and narrow duct in the head of the pancreas that drains through the major papilla (ventral duct) and a much longer duct that drains most of the pancreatic secretions through the minor papilla (dorsal duct). The prevalence of PD has been reported to be approximately 7% to 12.6% in western populations and is the most common congenital pancreatic anatomical variant. On the other hand, it is relatively uncommon in Asia with an estimated incidence of less than 2% in the general population. Case 1: Clinical History: A 16 years old female was admitted with findings of acute pancreatitis. Patient referred for plain 2D / 3D MR Cholangiopancreatography (MRCP). Imaging Findings: • Dorsal pancreatic duct was seen to drain into duct of Sartorini and open in to the minor papilla. • Ventral duct was seen to open along with CBD into the major papilla. • A small channel was seen connecting these two ducts. • No ductal dilatation or intraductal calculi were noted. • Minimal soft tissue stranding of the peripancreatic fat was seen which was also seen to extend along the mesenteric vessels. • Minimal free fluid was noted in the pelvis. MRCP: Type 3 PD: Dorsal duct (pink) is seen to open directly into the minor papilla. Ventral duct (yellow) is seen to join CBD(orange) and open into the major papilla.
    [Show full text]
  • Congenital Duodenal Anomalies in the Adult
    PAPER Congenital Duodenal Anomalies in the Adult Alan P. Ladd, MD; James A. Madura, MD Background: Duodenal anomalies are defects in em- Main Outcome Measures: Surgical outcomes includ- bryologic development and usually present as gastric out- ing postoperative complications, deaths, and resolution let obstruction in infancy or early childhood. Occasion- of preoperative symptoms. ally, they remain asymptomatic until adulthood and, because they are unusual, may not be diagnosed. Results: The treatment for patients with duodenal webs was transduodenal web excision and duodenoplasty in 19 Hypothesis: Based on current experience and review of 22. Patients with annular pancreata were treated by tran- of the literature, recognition of diagnosis and the pre- section of the annulus and duodenoplasty (n=4) and proxi- ferred methods of treatment of duodenal anomalies can mal duodenal bypass (n=3). There were no operative deaths, be recommended. but 44% of patients had some complications. No pancre- atic fistulas occurred in patients who had division of an an- Design: Retrospective study of congenital duodenal nular pancreas. Outcome was considered excellent or good anomalies in adults. in 17 of 20 patients with duodenal webs, 4 of 7 with an- nular pancreata, and 2 of 2 with the combined anomaly. Setting: Tertiary care university medical center. Conclusions: Duodenal anomalies are rare in adults. Duo- Patients: Twenty-nine patients were observed and denal webs are best managed by transduodenal excision treated between 1983 and 1999 (19 women and 10 men; and duodenoplasty. Annular pancreas is generally best mean±SD age, 52±16 years). Twenty patients had duo- treated by duodenal bypass to the distal duodenum or the denal webs, 7 had annular pancreata, and 2 had both.
    [Show full text]
  • Chronic Pancreatitis: Introduction
    Chronic Pancreatitis: Introduction Authors: Anthony N. Kalloo, MD; Lynn Norwitz, BS; Charles J. Yeo, MD Chronic pancreatitis is a relatively rare disorder occurring in about 20 per 100,000 population. The disease is progressive with persistent inflammation leading to damage and/or destruction of the pancreas . Endocrine and exocrine functional impairment results from the irreversible pancreatic injury. The pancreas is located deep in the retroperitoneal space of the upper part of the abdomen (Figure 1). It is almost completely covered by the stomach and duodenum . This elongated gland (12–20 cm in the adult) has a lobe-like structure. Variation in shape and exact body location is common. In most people, the larger part of the gland's head is located to the right of the spine or directly over the spinal column and extends to the spleen . The pancreas has both exocrine and endocrine functions. In its exocrine capacity, the acinar cells produce digestive juices, which are secreted into the intestine and are essential in the breakdown and metabolism of proteins, fats and carbohydrates. In its endocrine function capacity, the pancreas also produces insulin and glucagon , which are secreted into the blood to regulate glucose levels. Figure 1. Location of the pancreas in the body. What is Chronic Pancreatitis? Chronic pancreatitis is characterized by inflammatory changes of the pancreas involving some or all of the following: fibrosis, calcification, pancreatic ductal inflammation, and pancreatic stone formation (Figure 2). Although autopsies indicate that there is a 0.5–5% incidence of pancreatitis, the true prevalence is unknown. In recent years, there have been several attempts to classify chronic pancreatitis, but these have met with difficulty for several reasons.
    [Show full text]