Himmelfarb Health Sciences Library, The George Washington University Health Sciences Research Commons Anesthesiology and Critical Care Medicine Faculty Anesthesiology and Critical Care Medicine Publications 1-2014 Considerations in perioperative assessment of valproic acid coagulopathy Claude Abdallah George Washington University Follow this and additional works at: http://hsrc.himmelfarb.gwu.edu/smhs_anesth_facpubs Part of the Anesthesia and Analgesia Commons APA Citation Abdallah, C. (2014). Considerations in perioperative assessment of valproic acid coagulopathy. Journal of Anaesthesiology Clinical Pharmacology, Volume 30, Issue 1 (). http://dx.doi.org/10.4103/0970-9185.125685 This Journal Article is brought to you for free and open access by the Anesthesiology and Critical Care Medicine at Health Sciences Research Commons. It has been accepted for inclusion in Anesthesiology and Critical Care Medicine Faculty Publications by an authorized administrator of Health Sciences Research Commons. For more information, please contact
[email protected]. [Downloaded free from http://www.joacp.org on Tuesday, February 25, 2014, IP: 128.164.86.61] || Click here to download free Android application for this journal Revv iew Article Considerations in perioperative assessment of valproic acid coagulopathy Claude Abdallah Department of Anesthesiology, Children’s National Medical Center, The George Washington University Medical Center, NW Washington, DC, USA Abstract Valproic acid (VPA) is one of the widely prescribed antiepileptic drugs in children with multiple indications. VPA-induced coagulopathy may occur and constitute a pharmacological and practical challenge affecting pre-operative evaluation and management of patients receiving VPA therapy. This review summarizes the different studies documenting the incidence, severity and available recommendations related to this adverse effect.