Integrin beta3 (Ab 773) Antibody Cat. No.: 79-317

Integrin beta3 (Ab 773) Antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Integrin β3 (Ab-773).

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse

Integrin beta3 (Ab-773) antibody was raised against a peptide sequence around aa. IMMUNOGEN: 771~775 (P-L-Y-K-E) derived from Human Integrin β3.

TESTED APPLICATIONS: IHC, WB

APPLICATIONS: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

SPECIFICITY: This antibody detects endogenous level of total Integrin β3 protein.

PREDICTED MOLECULAR 110 kDa WEIGHT:

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PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

CLONALITY: Polyclonal

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM BUFFER: NaCl, 0.02% sodium azide and 50% glycerol.

CONCENTRATION: 1 mg/mL

STORAGE CONDITIONS: Store antibody at -20˚C for up to one year.

Additional Info

OFFICIAL SYMBOL: ITGB3

GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, CREB2, CREBP1, Platelet membrane ALTERNATE NAMES: glycoprotein IIIa

ACCESSION NO.: NP_000203.2

PROTEIN GI NO.: 47078292

GENE ID: 3690

Background and References

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide BACKGROUND: array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

1) Chandhoke SK, et al. (2004) J Cell Sci; 117 (Pt 8): 1431-41. Datta A, et al. (2002) J Biol REFERENCES: Chem; 277 (6): 3943-9. Law DA, et al. (1996) J Biol Chem; 271 (18): 10811-5.

ANTIBODIES FOR RESEARCH USE ONLY.

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