Integrin beta3 (Ab 773) Antibody Cat. No.: 79-317 Integrin beta3 (Ab 773) Antibody Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Integrin β3 (Ab-773). Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human, Mouse Integrin beta3 (Ab-773) antibody was raised against a peptide sequence around aa. IMMUNOGEN: 771~775 (P-L-Y-K-E) derived from Human Integrin β3. TESTED APPLICATIONS: IHC, WB APPLICATIONS: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100 SPECIFICITY: This antibody detects endogenous level of total Integrin β3 protein. PREDICTED MOLECULAR 110 kDa WEIGHT: October 1, 2021 1 https://www.prosci-inc.com/integrin-beta3-ab-773-antibody-79-317.html Properties PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide. CLONALITY: Polyclonal CONJUGATE: Unconjugated PHYSICAL STATE: Liquid Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM BUFFER: NaCl, 0.02% sodium azide and 50% glycerol. CONCENTRATION: 1 mg/mL STORAGE CONDITIONS: Store antibody at -20˚C for up to one year. Additional Info OFFICIAL SYMBOL: ITGB3 GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, CREB2, CREBP1, Platelet membrane ALTERNATE NAMES: glycoprotein IIIa ACCESSION NO.: NP_000203.2 PROTEIN GI NO.: 47078292 GENE ID: 3690 Background and References Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide BACKGROUND: array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. 1) Chandhoke SK, et al. (2004) J Cell Sci; 117 (Pt 8): 1431-41. Datta A, et al. (2002) J Biol REFERENCES: Chem; 277 (6): 3943-9. Law DA, et al. (1996) J Biol Chem; 271 (18): 10811-5. ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. October 1, 2021 2 https://www.prosci-inc.com/integrin-beta3-ab-773-antibody-79-317.html.