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Steroidal Glycoside Compounds As Core 2 Glcnac-T Inhibitors
(19) TZZ_ZZ _T (11) EP 1 909 802 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 31/704 (2006.01) A61K 31/7048 (2006.01) 21.05.2014 Bulletin 2014/21 A61K 31/706 (2006.01) A61P 1/04 (2006.01) A61P 1/06 (2006.01) A61P 1/16 (2006.01) (2006.01) (2006.01) (21) Application number: 06755733.0 A61P 3/10 A61P 7/02 A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) (22) Date of filing: 06.07.2006 A61P 17/06 (2006.01) A61P 31/18 (2006.01) A61P 19/02 (2006.01) (86) International application number: PCT/GB2006/002518 (87) International publication number: WO 2007/003957 (11.01.2007 Gazette 2007/02) (54) Steroidal glycoside compounds as core 2 GlcNAc-T inhibitors Steroidale Glycosid-Verbindungen als core 2 GlcNAc-T-Hemmer Glycosides steroïdiens en tant qu’inhibiteurs du core 2 GlcNAc-T (84) Designated Contracting States: WO-A-2004/062675 WO-A-2005/060977 AT BE BG CH CY CZ DE DK EE ES FI FR GB GR WO-A-2005/120535 WO-A2-01/32679 HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI WO-A2-02/069980 CN-A- 1 415 625 SK TR US-A- 4 602 003 US-A- 5 104 856 US-A1- 2003 148 962 (30) Priority: 06.07.2005 GB 0513881 • DATABASE WPI 7 January 2004 (2004-01-07), (43) Date of publication of application: Derwent Publications Ltd., London, GB; Class 16.04.2008 Bulletin 2008/16 042,page 3, AN 2004-239758 XP002409228 HUANG H, LIU Z: "Medicine composition for (60) Divisional application: treating myocardial ischemia, angina pectoris 11163561.1 / 2 382 979 and cardiac infarction" -
(12) Patent Application Publication (10) Pub. No.: US 2017/0202238 A1 YANNIOS (43) Pub
US 20170202238A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0202238 A1 YANNIOS (43) Pub. Date: Jul. 20, 2017 (54) DIETARY SUPPLEMENT COMPOSITIONS (52) U.S. Cl. WITH ENHANCED DELIVERY MATRIX, CPC ............... A23G 3/368 (2013.01); A23G 3/36 GUMMIES, CHOCOLATES, ATOMIZERS (2013.01); A23G 3/48 (2013.01); A23 V AND POWDERS CONTAINING SAME, AND 2002/00 (2013.01) METHODS OF MAKING SAME (71) Applicant: James John YLANNIOS, (57) ABSTRACT PLACENTIA, CA (US) (72) Inventor: James John YLANNIOS, A method of making dietary Supplement compositions PLACENTIA, CA (US) includes generating an aqueous phase (A1) having one or (21) Appl. No.: 15/475,636 more dietary Supplement nutrients (DSN1), generating an oil phase (O1), performing a first homogenizing step by mixing (22) Filed: Mar. 31, 2017 A1 and O1 thereby forming A1/O1 composition, performing a second homogenizing step by mixing the A1/O1 compo Related U.S. Application Data sition and the further added DSN2, performing a third (63) Continuation of application No. 15/414,877, filed on homogenizing step by mixing the A1/O1/DSN2 composition Jan. 25, 2017, which is a continuation-in-part of and a first flavor (F1), performing a fourth homogenizing application No. 14/132,486, filed on Dec. 18, 2013, step by mixing the A1/O1/DSN2/F1 composition and a gum now Pat. No. 9,585,417. dispersed with glycerin (GG), and performing a fifth homog enizing step by mixing the A1/O1/DSN2/F1/GG composi (60) Provisional application No. 61/837.414, filed on Jun. -
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PEER-REVIEWED ARTICLE bioresources.com GC-MS Characterisation of Sapogenins from Sisal Waste and a Method to Isolate Pure Hecogenin Jener David G. Santos * and Alexsandro Branco ** Five steroidal sapogenins (tigogenin, neotigogenina, hecogenin, gloriogenin, and dehydrohecogenin) were characterised by gas chromatography coupled with mass spectrometry (GC-MS) from a hydrolysed extract of sisal waste. In addition, pure hecogenin, an important raw material for the pharmaceutical industry, was obtained from this waste by selective liquid-liquid extraction of saponins with only hecogenin as aglycone, followed by acid hydrolysis. The yield of pure hecogenin was 460 mg.Kg-1 of sisal waste. Keywords: Agave sisalana; Sisal waste; Extraction; Steroids; Hecogenin Contact information: Laboratory of Phytochemistry, State University of Feira de Santana, 44.036-900 Feira de Santana, Bahia, Brazil; Corresponding authors: *[email protected], **[email protected] INTRODUCTION Steroidal sapogenins are a glycone non-sugar portion of the saponin molecule used for the semi-synthesis of bioactive compounds. Example compounds used in this application include the following: smilagenin, sarsasapogenin, diosgenin, yamogenin, tigogenin, neotigogenin, gloriogenin, gentrogenin, hecogenin, sisalagenin, 9-dehydro- hecogenin, and gitogenin (Agrawal et al. 1985). Among these steroidal sapogenins, diosgenin, sarsasapogenin, and hecogenin are particularly important. The usefulness of hecogenin (Fig. 1) as a synthetic starting material is due to the presence of an oxygen atom in the C-12 position that can be moved to the C-11 position. This makes it possible to introduce the 9-11 double bond required for the syntheses of corticosteroids (Beauvoir 1976). Fig. 1. Chemical structural of hecogenin In the 1940s, steroidal sapogenins achieved great economic importance because of their transformation into pharmaceutically valuable derivatives such as corticosteroids (prednisone, dexamethasone, betamethasone, triamcinolone, and others), sexual hormones, and steroid diuretics (Fernández-Herrera et al. -
(Ebook) Herbal Medicine.Pdf
Herbal medicine is considered as the oldest form of medicines. Herbal Medicine is the oldest form of medicine and has at one time been the dominant healing therapy throughout all cultures and the peoples of the world. The first examples of the use of herbs as medicines date back to the very dawn of mankind. Archaeologists have found many evidences of the use of herbs by Neanderthal man in Iraq some sixty thousand years ago. All of the ancient civilizations – the Mesopotamian, Egyptian, Greek, Chinese, Indian and Roman used herbs as an integral part of their various medical systems. The first famous Herbalist, who stressed the importance of nature in healing, was Hippocrates, known as the “Father of Medicine”. It is on the long and continuous history of herbs as medicine, together with knowledge taken from modern scientific research, that today’s herbalism is based. The Philippine Institute of Traditional an Alternative Health Care has approved the 10 most common herbal medicines and as approved by the Department of Health. Acapulpo. Scientific Name- Cassia Alata It Contains chrysophic acid, a fungicide and saponin, a laxative. Uses 1. Treatment of skin dideases such as insect bites, ringworm, eczema, scabies and itchiness 2. Expectorant for bronchitis and dyspnea 3. alleviation of asthma symptom 4. Diuretic and purgative 5. Laxative to expel intestinal parasites and other stomach problems 6. Ampalaya or Bitter Melon. Scientific Name- Momordica Charantia Herbal medicine known to cure Diabetes (flavanoids and alkaloids). It is good source of Vitamins A, B, and C, iron, folic acid, phosphorous and calcium. Ampalaya Scientific Name- Mormordica Charantia 1. -
From Medicinal Plant Raw Material to Herbal Remedies 271
Provisional chapter Chapter 16 From Medicinal Plant Raw Material to FromHerbal Medicinal Remedies Plant Raw Material to Herbal Remedies SofijaSofija M. M. Djordjevic Djordjevic Additional information is available at the end of the chapter Additional information is available at the end of the chapter http://dx.doi.org/10.5772/66618 Abstract The use of medicinal plants is old as the existence of mankind. According to World Health Organization (WHO) data, about 80% of world population are using products based on medicinal herbs. Phytotherapy is based on the use of herbal drugs and medicinal prod- ucts for the purpose of prevention and treatment. Rational phytotherapy is a modern concept of herbal medicines using, which are made of standardized herbal extracts. The quality of each final product is guaranteed by the use of raw materials of a standard qual- ity, defined process of production, and validated equipment. Quality control of herbal drugs and herbal isolates (tinctures, extracts, and essential oils) is done according to the requirements of Pharmacopoeia and other relevant regulations. The scope of phy- topreparation quality control depends on its pharmaceutical form. The formulation of a new phytopreparation is a process that has strictly defined phases: from analysis of liter- ature and market, through defining recipes, validation of the production process, quality control of a final product to the preparation of technological and registration documents. The aim of this chapter is to present the process of herbal preparations production from selecting plant raw materials to herbal remedies (on the examples of making tea, tea mix- ture, drops, gels, and capsules). -
Assessment of Anti-Inflammatory Effects of Japanese Kampo Medicine and Functional Foods
Functional Foods in Health and Disease 2019; 9(2): 79-91 Page 79 of 91 Review Article Open Access Assessment of anti-inflammatory effects of Japanese Kampo medicine and functional foods Mikio Nishizawa1, Tadayoshi Okumura2,3, and Yukinobu Ikeya4 1Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan; 2Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan; 3Department of Surgery, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan; 4Department of Pharmacy Educational Assist Center, Daiich University of Pharmacy, Minami-ku, Fukuoka, 815-8511, Japan Corresponding author: Mikio Nishizawa, M.D., Ph.D., Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525- 8577, Japan. Submission Date: October 3rd, 2018, Acceptance Date: February 25th, 2019, Publication Date: February 28th, 2019 Citation: Nishizawa M., Okumura T., Ikeya Y. Comparison of anti-inflammatory effects of Japanese Kampo medicine and functional foods. Functional Foods in Health and Disease 2019; 9(2): 79-91. DOI: https://doi.org/10.31989/ffhd.v9i2.566 ABSTRACT Traditional Japanese drugs called Kampo medicine are widely used in Japan. Each Kampo medicine consists of several crude drugs, most of which are derived from medicinal plants. Clinical administration has empirically evaluated the effects of Kampo medicine. In contrast, functional foods are prepared from foods and edible plants (e.g., herbs, vegetables, and fruits). Due to the relatively low content of pharmacologically active constituents in functional foods, their effectiveness has not been well evaluated and thus should be better investigated. Kampo medicine and functional foods have beneficial effects for humans, and many of them exhibit anti-inflammatory effects. -
Naturally Occurring Saponins: Chemistry and Biology
Journal of Poisonous and Medicinal Plant Research Vol. 1(1), pp. 001-006, May, 2013 Available online at http://www.apexjournal.org ISSN 2315-8834© 2013 Apex Journal International Review Naturally occurring saponins: Chemistry and biology J. S. Negi 1*, P. S. Negi 2, G. J. Pant 2, M. S. M. Rawat 2, S. K. Negi 3 1Herbal Research and Development Institute, Mandal, Gopeshwar (Chamoli) - 246 401, Uttarakhand, India. 2Department of Chemistry, HNB Garhwal University, Srinagar (Garhwal)- 246 174, Uttarakhand, India. 3Department of Botany, HNB Garhwal University, Srinagar (Garhwal) - 246 174, Uttarakhand, India. Accepted 2 April, 2013 Naturally occurring saponins are glycosides of steroids, alkaloids and triterpenoids. They are widely distributed in nature and reported to be present in 500 genera of plants. A wide variety of plants belonging to family Liliaceae, Dioscoreaceae, Solanaceae, Sapindaceae and Agavaceae are the major source of saponins. They are amorphous substances having high molecular weight and are soluble in water and alcohol to produce foam but organic solvents inhibit their foaming property. Plants saponins are generally extracted into butanol through liquid-liquid partition and separated through column chromatography using silica gel as adsorbent and chloroform: methanol as mobile phase. HPLC, GC, Sephadex LH-20 Chromatography, DCCC, preparative paper chromatography and TLC were also used for the separation and isolation of saponins. The structures of saponins were determined by several spectroscopic techniques, viz., UV, IR, 1H NMR, 13 C NMR and Mass spectroscopy. Saponins possess several biological activities such as antioxidant, immunostimulant, antihepatotoxic, antibacterial, anticarcinogenic, antidiarrheal, antiulcerogenic, antioxytoxic, antihypoglycemic, anticytotoxic and antimolluscicidal. Saponins are biologically synthesized by C5 isoprene units through cytosolic mevalonate pathway. -
Phytochemical and Biological Investigations of Asparagus Adscendens and Trillium Govanianum
Phytochemical and Biological Investigations of Asparagus adscendens and Trillium govanianum By Kashif Maqbool Khan CIIT/FA12-R60-004/ATD PhD Thesis In Pharmacy COMSATS University Islamabad, Abbottabad Campus - Pakistan Fall, 2018 COMSATS University Islamabad Phytochemical and Biological Investigations of Asparagus adscendens and Trillium govanianum A Thesis Presented to COMSATS University Islamabad, Abbottabad Campus In partial fulfillment of the requirement for the degree of PhD (Pharmacy) By Kashif Maqbool Khan CIIT/FA12-R60-004/ATD Fall, 2018 ii Phytochemical and Biological Investigations of Asparagus adscendens and Trillium govanianum A Post Graduate Thesis submitted to the Department of Pharmacy as partial fulfillment of the requirement for the award of Degree of Ph.D in Pharmacy. Name Registration Number Kashif Maqbool Khan CIIT/FA12-R60-004/ATD Supervisor Dr. Abdul Manann Associate Professor Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus Co-Supervisor Dr. Muhammad Arfan Associate Professor Department of Chemistry, School of Natural Sciences (SNS) National University of Sciences & Technology (NUST), Islamabad iii iv v vi vii DEDICATION Dedicated to my family and friends who were the pillars of support during my PhD study viii ACKNOWLEDGEMENTS I bow my head before Almighty Allah, The omnipotent, The omnipresent, The merciful, The most gracious, The compassionate, The beneficent, who is the entire and only source of every knowledge and wisdom endowed to mankind and who blessed me with the ability to do this work. It is the blessing of Almighty Allah and His Prophet Hazrat Muhammad (Sallallaho Alaihe Wasallam) which enabled me to achieve this goal. I would like to take this opportunity to convey my cordial gratitude and appreciation to my worthy, reverently and zealot supervisor Dr. -
Yamogenin 3-O-β- <Emphasis Type="Smallcaps">D
J. Chem. Sci., Vol. 116, No. 2, March 2004, pp. 79–82. © Indian Academy of Sciences. Yamogenin 3–O–b–D-glucopyranosyl (1 ® 4)–O–a–D-xylopyranoside from the seeds of Trigonella foenum-graecum V K SAXENA* and ALBERT SHALEM Department of Chemistry, Dr H S Gour University, Sagar 470 003, India e-mail: [email protected] MS received 17 March 2003; revised 10 June 2003 Abstract. Trigonella foenum-graecum (NO – Leguminosae) is cultivated in many parts of India. It has been found to possess significant medicinal value. Its leaves are used both internally and externally to re- duce swelling, prevent falling of hair and in treating burns. Its seeds are carminative, antipyretic, anthelmintic and diuretic, and are also useful in treatment of dropsy, chronic cough, heart diseases, bron- chitis, piles and small pox. This plant also possesses antidiabetic property. The present communication deals with the isolation and identification of steroidal saponin SA-III, characterised as yamogenin 3–O–b–D-glucopyranosyl (1 ® 4)–O–a–D-xylopyranoside, which was iso- lated from the seeds of Trigonella foenum-graecum. Keywords. Trigonella foenum-graecum; Leguminosae; steroidal saponin; yamogenin 3–O–b–D-gluco- pyranosyl (1 ® 4)–O–a–D-xylopyranoside. 1. Introduction trum of SA-III shows the spiroketal nature of SA- III. It shows all characteristic colour reactions of Trigonella foenum–graecum1–3 (NO – Leguminosae) steroidal saponin9,10 and also gives positive Molisch and is cultivated in many parts of India. It has been test for glycoside. found to possess significant medicinal value. Its Compound SA-III on acid hydrolysis yielded SA- leaves are used both internally and externally to re- III (A), C27H42O3, m.pt. -
University of Copenhagen, Rolighedsvej 25, 1958 Frederiksberg, Denmark
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Copenhagen University Research Information System Ethnobotanical knowledge of the Kuy and Khmer people in Prey Lang, Cambodia Turreira Garcia, Nerea; Argyriou, Dimitrios; Chhang, Phourin; Srisanga, Prachaya; Theilade, Ida Published in: Cambodian Journal of Natural History Publication date: 2017 Document version Publisher's PDF, also known as Version of record Citation for published version (APA): Turreira Garcia, N., Argyriou, D., Chhang, P., Srisanga, P., & Theilade, I. (2017). Ethnobotanical knowledge of the Kuy and Khmer people in Prey Lang, Cambodia. Cambodian Journal of Natural History, 2017(1), 76-101. Download date: 08. Apr. 2020 76 N. Turreira-García et al. Ethnobotanical knowledge of the Kuy and Khmer people in Prey Lang, Cambodia Nerea TURREIRA-GARCIA1,*, Dimitrios ARGYRIOU1, CHHANG Phourin2, Prachaya SRISANGA3 & Ida THEILADE1,* 1 Department of Food and Resource Economics, University of Copenhagen, Rolighedsvej 25, 1958 Frederiksberg, Denmark. 2 Forest and Wildlife Research Institute, Forestry Administration, Hanoi Street 1019, Phum Rongchak, Sankat Phnom Penh Tmei, Khan Sen Sok, Phnom Penh, Cambodia. 3 Herbarium, Queen Sirikit Botanic Garden, P.O. Box 7, Maerim, Chiang Mai 50180, Thailand. * Corresponding authors. Email [email protected], [email protected] Paper submitted 30 September 2016, revised manuscript accepted 11 April 2017. ɊɮɍɅʂɋɑɳȶɆſ ȹɅƺɁɩɳȼˊɊNJȴɁɩȷ Ʌɩȶ ɑɒȴɊɅɿɴȼɍɈɫȶɴɇơȲɳɍˊɵƙɈɳȺˊƙɁȪɎLJɅɳȴȼɫȶǃNjɅȷɸɳɀɹȼɫȶɈɩɳɑɑ ɳɍˊɄɅDžɅɄɊƗƺɁɩɳǷȹɭɸ -
A Dictionary of the Plant Names of the Philippine Islands," by Elmer D
4r^ ^\1 J- 1903.—No. 8. DEPARTMEl^T OF THE IE"TEIlIOIi BUREAU OF GOVERNMENT LABORATORIES. A DICTIONARY OF THE PLAIT NAMES PHILIPPINE ISLANDS. By ELMER D, MERRILL, BOTANIST. MANILA: BUREAU OP rUKLIC I'RIN'TING. 8966 1903. 1903.—No. 8. DEPARTMEE^T OF THE USTTERIOR. BUREAU OF GOVEENMENT LABOEATOEIES. r.RARV QaRDON A DICTIONARY OF THE PLANT PHILIPPINE ISLANDS. By ELMER D. MERRILL, BOTANIST. MANILA: BUREAU OF PUBLIC PRINTING. 1903. LETTEE OF TEANSMITTAL. Department of the Interior, Bureau of Government Laboratories, Office of the Superintendent of Laboratories, Manila, P. I. , September 22, 1903. Sir: I have the honor to submit herewith manuscript of a paper entitled "A dictionary of the plant names of the Philippine Islands," by Elmer D. Merrill, Botanist. I am, very respectfully. Paul C. Freer, Superintendent of Government Laboratories. Hon. James F. Smith, Acting Secretary of the Interior, Manila, P. I. 3 A DICTIONARY OF THE NATIVE PUNT NAMES OF THE PHILIPPINE ISLANDS. By Elmer D. ^Ikkrii.i., Botanist. INTRODUCTIOX. The preparation of the present work was undertaken at the request of Capt. G. P. Ahern, Chief of the Forestry Bureau, the objeet being to facihtate the work of the various employees of that Bureau in identifying the tree species of economic importance found in the Arcliipelago. For the interests of the Forestry Bureau the names of the va- rious tree species only are of importance, but in compiling this list all plant names avaliable have been included in order to make the present Avork more generally useful to those Americans resident in the Archipelago who are interested in the vegetation about them. -
Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment
Molecules 2013, 18, 14670-14693; doi:10.3390/molecules181214670 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Review Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment Hemant Kumar, Soo-Yeol Song, Sandeep Vasant More, Seong-Mook Kang, Byung-Wook Kim, In-Su Kim and Dong-Kug Choi * Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chung-ju 380-701, Korea; E-Mails: [email protected] (H.K.); [email protected] (S.-Y.S.); [email protected] (S.V.M.); [email protected] (S.-M.K.); [email protected] (B.-W.K.); [email protected] (I.-S.K.) * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +82-43-840-3610; Fax: +82-43-840-3872. Received: 9 September 2013; in revised form: 8 November 2013 / Accepted: 18 November 2013 / Published: 26 November 2013 Abstract: Hanbang, the Traditional Korean Medicine (TKM), is an inseparable component of Korean culture both within the country, and further afield. Korean traditional herbs have been used medicinally to treat sickness and injury for thousands of years. Oriental medicine reflects our ancestor’s wisdom and experience, and as the elderly population in Korea is rapidly increasing, so is the importance of their health problems. The proportion of the population who are over 65 years of age is expected to increase to 24.3% by 2031. Cognitive impairment is common with increasing age, and efforts are made to retain and restore the cognition ability of the elderly. Herbal materials have been considered for this purpose because of their low adverse effects and their cognitive-enhancing or anti-dementia activities.