Malate

Clinical Applications  Supports Energy Production*

 Supports Cardiovascular Function* Distributed

 Supports carbohydrate tolerance*  Supports Bone health*

by:

Newark Road, 625 Barksdale Research Adaptogen

Magnesium Malate is a highly bioavailable form of magnesium. It contains di-magnesium malate, which is

, magnesium bound to . DE

1 9711

• Supports Cardiovascular Health*

All Adaptogen Research Formulas Meet or Exceed cGMP Quality Standards Suite

113

Discussion Magnesium Malate

Magnesium is an essential that serves as an enzyme cofactor for over three hundred biochemical reactions in the body. The need for magnesium throughout the body is reflected in the fact that the adult human body contains approximately 25 grams of magnesium, divided among the skeleton, muscle tissue, blood, and other areas. Glutamine is the most abundant free amino acid in the body and is an energy substrate for most cells— Magnesiumespecially malate enterocytes is a form (intestinal of magnesium epithelial bound cells) to and malic immune acid, cells.which It is is aalso compound an essential found component naturally infor fruits and vegetables, and is responsible for the tart flavor of rhubarb and green apples. Magnesium is a required numerous metabolic functions, including acid-base (pH) homeostasis; nitrogen supply; neurotransmitter cofactor for enzymes that harness energy from carbohydrates, while malic acid is .[1,2]an intermediary of the complex processproduction; that generates and synthesis energy of fromglutathione, all fuel glucose, sources, proteins, including and carbohydrates, nucleic acids fats, Glutamine and ketones. is primarily Therefore , magnesiumsynthesized malate and may stored be in especially skeletal muscle. beneficial It is forconsidered individuals a conditionall who experiencey essential occasional amino acid low because, energy and fatigue.under normal circumstances, the body can manufacture enough to sustain physiological demands. However, under metabolic stress—such as illness/disease, injury, infection, surgery, chemotherapy, Magnesium may also support: Prolonged exercise, or environmental stress—glutamine is released from body stores into the bloodstream Cardiovascular and transported function: to tissues Owing in deficit. to its Increased role in muscledemands contraction make exogenous and relaxation, glutamine and sources nerve (food, conduction, magnesisupplements)um may help a necessity support healthy.*[2] blood pressure levels and cardiovascular function. Support During and Recovery After Stress States During stress states, the Healthy carbohydrate tolerance: Magnesium is indispensable for converting carbohydrate (glucose) to energy, body’s glutamine requirement exceeds supply, severely reducing both plasma and skeletal muscle

and is also required for proper functioning of the insulin receptor. Individuals who experience occasional issues .[1] related pools to blood of free glucose glutamine levels Withoutand carbohydrate adequate toleranceglutamine mayto meet benefit the fromneeds supplemental of the intestine, magnesium. immune system, and vital organs, a negative nitrogen balance and catabolism can result.[3] Nitrogen is necessary to repair Bonewounds health: and Sixty keep percent the vital of organs the magnesium functioning; in approximately the human body one is third found of this in the nitrogen skeleton. comes Magnesium from is an essential element of the physical structure of bone tissue. Supplementing with alone often does not have glutamine. Adequate nutrition, which includes glutamine, can help spare host energy reserves and impede the desired effect of strengthening.[4] bones; maintenance of healthy bones requires adequate magnesium, along with proteinrecovery and complications other mineral cofactorsIn fact, it .has. been recommended that patients preparing for elective surgery ready themselves nutritionally, in part through glutamine supplementation, to optimize recovery.[5] Research also suggests glutamine may help diminish risks associated with conventional therapeutics—such as high-dose chemotherapy and radiation—by supporting mucosal integrity, immune competence, and glutathione biosynthesis.*[4,6,7]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested Use

As a dietary supplement, take two capsules per day with meals, or as directed by your health care practitioner.

Caution

Keep out of reach of children.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Distributed by: Adaptogen Research 625 Barksdale Road, Suite 113 Newark , DE 19711