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Protein and Antibody Engineering Summit N Engineering Antibodies N Engineering Bispecifics 2020 PLENARY KEYNOTES Oncology Mabs Vs 12th Annual 9 - 12 NOVEMBER 2020 FINAL DAYS TO REGISTER Engineering n Display of Biologics Protein and Antibody Engineering Summit n Engineering Antibodies n Engineering Bispecifics 2020 PLENARY KEYNOTES Oncology mAbs vs. Bugs - Antibody n Antibody-Drug Conjugates Therapies for Infectious Disease n Advancing Bispecifics Steve Martin, PhD n Novel Targets Vice President, Biopharm Discovery, GlaxoSmithKline Analytical Clinical Trials on Stimulating n Optimisation & Developability Innate Immunity for Type 1 n Analytical Characterisation Diabetes, Alzheimer’s, and COVID n Aggregation & Stability Denise L. Faustman, MD, PhD Associate Professor & Director, Immunobiology Labs, Immunotherapy Massachusetts General Hospital n Tumour Microenvironment n CAR T, TIL & TCR Therapy BENEFITS OF A VIRTUAL PEGS EUROPE EVENT n Targeting Innate Immunity View more presentations at your convenience as your Virtual Expression registration includes On-Demand access n Systems Engineering See unpublished data & case studies from leading n Optimising Expression researchers from industry & academia n Purification Technologies Reduced registration fees and no travel or hotel costs Connect with the right attendees based on mutual interests and expertise Take advantage of facilitated networking opportunities Visit virtual exhibit booths, posters, and networking PEGSummitEurope.com roundtables without leaving home PREMIER SPONSORS PEGSummitEurope.com TABLE OF CONTENTS 1 12th Annual 9 - 12 NOVEMBER 2020 Protein and Antibody Engineering Summit TABLE OF CONTENTS Click to View Engineering Analytical Expression n Display of Biologics n Optimisation & Developability n Systems Engineering n Engineering Antibodies n Analytical Characterisation n Optimising Expression n Engineering Bispecifics n Aggregation & Stability n Purification Technologies Conference at a Glance Oncology Immunotherapy Plenary Keynote Session n Antibody-Drug Conjugates n Tumour Microenvironment Sponsors n Advancing Bispecifics n CAR T, TIL & TCR Therapy Sponsor & Exhibit Opportunities n Novel Targets n Targeting Innate Immunity Registration Information CONFERENCE-AT-A-GLANCE MONDAY 9 November TUESDAY 10 November WEDNESDAY 11 November THURSDAY 12 November ENGINEERING Display of Biologics Engineering Antibodies Engineering Bispecifics ONCOLOGY Antibody-Drug Conjugates Advancing Bispecifics Novel Targets Plenary ANALYTICAL Keynote Session Optimisation & Developability Analytical Characterisation Aggregation & Stability and VIP Networking IMMUNOTHERAPY Tumour Microenvironment CAR T, TIL & TCR Therapy Targeting Innate Immunity EXPRESSION Systems Engineering Optimising Expression Purification Technologies PEGSummitEurope.com TABLE OF CONTENTS 2 2020 PLENARY KEYNOTE SESSION 9 NOVEMBER 2020 | ALL TIMES WET (GMT+0) 14:00 Keynote Chairperson’s Remarks 14:55 Overview of Biologic COVID-19 Interventions Live Panel Discussion Janice M. Reichert, PhD, Executive Director, The Antibody Society PANEL MODERATOR: Janice M. Reichert, PhD, Executive Director, The Antibody Society 14:05 mAbs vs. Bugs: Antibody Therapies for Infectious Disease Steve Martin, PhD, Vice President, Biopharm Discovery, GlaxoSmithKline This year’s coronavirus pandemic has provided a stark reminder of the threat to global health posed by infectious disease and the need for new treatments. Renewed attention has been brought to the potential of antibodies as anti-infective therapeutics, which historically has been a challenging area for drug discovery. Synergies between modern vaccine PANELISTS: development approaches and antibody discovery technologies offer new James E Crowe Jr, Ann Scott Michael Hust, PhD, Prof & opportunities in the fight against our microbial foes. Carell Chair & Prof & Dir, Research Grp Leader, Vaccine Center, Vanderbilt Biotechnology, Technical Univ 14:30 Clinical Trials on Stimulating Innate Immunity for Type 1 Diabetes, University Medical Center of Braunschweig Alzheimer’s, and COVID Denise L. Faustman, MD, PhD, Associate Professor & Director, Immunobiology Labs, Massachusetts General Hospital 15:20 Refresh Break - View Our Virtual Exhibit Hall It has become apparent that perhaps in the developed world, there is less lifelong innate immunity. This is consistent with the Hygiene Hypothesis 15:40 Problem-Solving Breakout Discussions - View Our Virtual Exhibit Hall and maybe made worse by less exposure to the BCG vaccine. In this Join your colleagues and fellow delegates for a focused, informal discussion moderated by a presentation we will use BCG as an example of potent innate immune member of our speaking faculty. A small group format allows participants to meet potential stimulation from data from human clinical trials. The impact of stimulated collaborators, share examples from their own work and discuss ideas with peers. innate immunity may have implications for infectious diseases such as COVID, for changes in metabolism related to diabetes and finally perhaps a growing human data 16:30 Close of Day set on benefit in Alzheimer’s disease. The best biologics technology meeting in Europe: A must-attend conference for novel biologics. Rakesh D., PhD, President & CEO, Bionavigen PEGSummitEurope.com TABLE OF CONTENTS 3 SPONSORS PREMIER SPONSORS CORPORATE SPONSORS CORPORATE SUPPORT SPONSOR PEGSummitEurope.com TABLE OF CONTENTS 4 ENGINEERING STREAM 10 NOVEMBER 2020 | ALL TIMES WET (GMT+0) 7th Annual Display of Biologics Leading the Way for New Classes of Therapy Bonus Plenary Keynote Session The use of antibody engineering combined with subcellular trafficking analyses to design therapeutic Don’t miss the bonus Plenary Keynote Session and Problem-Solving Breakouts on Monday! This day is antibodies in two areas will be discussed: First, the development of engineered antibodies that clear included in all Premium and Standard package registrations. pathogenic antibodies. Second, the design of antibody-drug conjugates (ADCs) that deliver their cytotoxic payload more efficiently to lysosomes within cells, resulting in a strategy to generate ADCs that CO-PRESENTATION: BREAKOUT: Antibody Engineering Approaches to Improve are effective at lower doses. Efficacy of Biologics for Autoimmune Disease E. Sally Ward, PhD, Director, Translational Immunology; Professor, Molecular Immunology, 10:00 Discovery of Claudin 6 (CLDN6) and Claudin 18.2 (CLDN18.2) Monoclonal Centre for Cancer Immunology, University of Southampton Antibodies with Best-in-Class Specificity Joseph Rucker, PhD, Vice President, Research & Development, Integral Molecular Ahuva Nissim, PhD, Professor, Antibody and Therapeutic Engineering, William Harvey Oncology targets Claudin 6 (CLDN6) and 18.2 (CLDN18.2) are overexpressed in select cancers but Research Institute, Queen Mary University of London are absent in most adult healthy tissues. Using our MPS Antibody Discovery platform, we discovered and humanized lead candidate antibodies that bind unique residues on CLDN6 but not closely related • Targeting therapy to diseased tissue epitopes receptors CLDN9, CLDN3, and CLDN4, or members of the human proteome. We also present a panel of • Targeting FcRn to modulate antibody dynamics for the treatment of autoimmunity humanized CLDN18.2 MAbs with picomolar affinities that are superior to the clinical-stage benchmark. • Engineering antibodies to enhance the clearance of inflammatory mediators Generating MAbs Against Multi-Pass Membrane Proteins 10:20 Coffee Break - View Our Virtual Exhibit Hall Joseph Rucker, PhD, VP of Research and Development, Integral Molecular CUTTING-EDGE DRUG DEVELOPMENT FOR INFLAMMATORY AND Key considerations in antigen design Accessing conserved and functional epitopes AUTOIMMUNE DISEASE (CONT.) Finding your lead molecule 10:35 Post-Translational Modification and Disease-Potential Targets for Therapy Ahuva Nissim, PhD, Professor, Antibody and Therapeutic Engineering, William Harvey Research Institute, 16:30 Close of Day Queen Mary University of London We discovered that auto reactivity in arthritis is against neoepitopes formed as a result of oxidative TUESDAY 10 NOVEMBER post-translational modification (oxPTM) collagen type II (oxPTM-CII) that are formed in the arthritic joints. We showed that targeting of a payload drug by anti-oxPTM-CII antibody to inflamed arthritic joints CUTTING-EDGE DRUG DEVELOPMENT FOR INFLAMMATORY AND (Etanercept or viral IL-10) and hence nanoparticles loaded with multiple drugs. We also showed that anti- oxPTM-CII antibodies can detect early OA before cartilage erosion. AUTOIMMUNE DISEASE 10:55 Early Detection of Osteoarthritis in the Rat with an Antibody Specific to Type II 9:00 KEYNOTE PRESENTATION: Why We Develop Autoimmune Diseases: Collagen Modified by Reactive Oxygen Species Hyperstimulation of the Immune System Anne Gigout, PhD, Group Leader in vivo Pharmacology, Galapagos, Romainville, France Yehuda Shoenfeld, MD, FRCP, MaACR, Past Incumbent of the Laura Schwarz-Kipp Chair, We used an antibody specific to oxidative post-translationally modified type II collagen (oxPTM-CII) to Research of Autoimmune Diseases, Tel-Aviv University stain rat cartilage in two different chronic osteoarthritis models. Several time points were evaluated as Autoimmune diseases are genetics, HLADRB1 haplotypes are prevalent with diverse early as one day post operation. We could observe that oxPTM-CII staining is mainly localized in the deep autoimmune diseases. Hyperstimulation of genetically prone subjects bearing HLABRB1 may lead zone and is detectable before the appearance of cartilage lesions. It indicates that oxPTM-CII could
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