bioRxiv preprint doi: https://doi.org/10.1101/820365; this version posted October 28, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Over 50000 metagenomically assembled draft genomes for the 2 human oral microbiome reveal new taxa 3 Jie Zhu1, 2, ‡, Liu Tian1, 2, ‡, Peishan Chen1, 3, Mo Han1, 4, Liju Song1, 2, Xin Tong1, 2, 4 Zhipeng Lin1, Xing Liu1, Chuan Liu1, Xiaohan Wang1, Yuxiang Lin1, Kaiye Cai1, 5 Yong Hou1, Xun Xu1, 2, Huanming Yang1, 5, Jian Wang1, 5, Karsten Kristiansen1, 4, 6 Liang Xiao1, 3, 6, Tao Zhang1, 4, Huijue Jia1, 2, 9, * & Zhuye Jie1, 2, 4, * 7 8 1 BGI-Shenzhen, Shenzhen 518083, China 9 2 Shenzhen Key Laboratory of Human Commensal Microorganisms and Health 10 Research, BGI-Shenzhen, Shenzhen 518083, China 11 3 Shenzhen Engineering Laboratory of Detection and Intervention of human intestinal 12 microbiome 13 4 Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 14 University of Copenhagen, DK-2100 Copenhagen, Denmark 15 5 James D. Watson Institute of Genome Sciences, Hangzhou 310058, China 16 6 BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China 17 ‡ These authors contributed equally to this work 18 *Correspondence should be addressed to Z.J.
[email protected], H.J. 19
[email protected]. 20 21 ABSTRACT 22 The oral cavity of each person is home for hundreds of bacterial species. While 23 taxa for oral diseases have been well studied using culture-based as well as 24 amplicon sequencing methods, metagenomic and genomic information remain 25 scarce compared to the fecal microbiome.