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Accepted Manuscript

Deregulation of Immune Response Genes in Patients with Epstein-Barr Virus- Associated Gastric Cancer and Outcomes

Sun Young Kim, Charny Park, Ha-Jung Kim, Ji-Hyun Park, Jinha Hwang, Jong-Il Kim, Min Gew Choi, Sung Kim, Kyoung- Mee Kim, Myung-Soo Kang

PII: S0016-5085(14)01142-1 DOI: 10.1053/j.gastro.2014.09.020 Reference: YGAST 59350

To appear in: Gastroenterology Accepted Date: 15 September 2014

Please cite this article as: Kim SY, Park C, Kim H-J, Park J-H, Hwang J, Kim J-I, Choi MG, Kim S, Kim K-M, Kang M-S, Deregulation of Immune Response Genes in Patients with Epstein-Barr Virus- Associated Gastric Cancer and Outcomes, Gastroenterology (2014), doi: 10.1053/j.gastro.2014.09.020.

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

All studies published in Gastroenterology are embargoed until 3PM ET of the day they are published as corrected proofs on-line. Studies cannot be publicized as accepted manuscripts or uncorrected proofs. ACCEPTED MANUSCRIPT

Deregulation of Immune Response Genes in Patients with Epstein-Barr Virus- Associated Gastric Cancer and Outcomes

Sun Young Kim1, 2, $, Charny Park3, $, Ha-Jung Kim1, Ji-Hyun Park1, 2, Jinha Hwang4, Jong-Il Kim4, 5, 6 Min Gew Choi 7, Sung Kim 7, Kyoung- Mee Kim 2, 8, *, Myung-Soo Kang1, 2, * 1Samsung Advanced Institute for Health Sciences and Technology (SAIHST) and 2Samsung Biomedical Research Institute (SBRI), Center for Future Sciences, Medical Center, School of Medicine, , Korea. 3Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea.4Department of Biomedical Sciences, Seoul National University Graduate School, 5Department of Biochemistry, Seoul National University College of Medicine, 6Genomic Medicine Institute (GMI), Medical Research Center, Seoul National University, Seoul, Korea, 7Department of Surgery, Center for Gastric Cancer, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, 8Department of Pathology & TranslationalMANUSCRIPT Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Running Title: Deregulation of Immune Response Genes in EBVaGC

$Equally contributed to this work

*Corresponding authors: Myung-Soo Kang, Samsung Advanced Institute for Health Sciences and Technology (SAIHST) and Samsung Biomedical Research Institute (SBRI), Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Korea 135-710. Tel:82-2-3410-1038, Fax: 82-2- 3410-0534; email:ACCEPTED [email protected], Kyoung-Mee Kim, 6Samsung Biomedical Research Institute (SBRI), Department of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-

dong, Gangnam-gu, Seoul, Korea 135-710. Tel: 82-2-3410-2800, Fax: 02-3410-6396;

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