USAN Naming Guidelines for Monoclonal Antibodies |
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1 Introduction
1 Introduction My subject—inWxation—is at once exotic and familiar. Russell Ultan in his pioneering study of the typology of inWxation (1975) noted that inWxes are rare compared to the frequency of other aYxes. The presence of inWxes in any language implies the presence of suYxes and/or preWxes, and no languages employ inWxation exclusively (Greenberg 1966: 92). The term ‘inWxation’ is also less familiar to students of linguistics than are such terms as preWxation and suYxation. The Oxford English Dictionary goes as far as deWning inWxes as what preWxes and suYxes are not: A modifying element inserted in the body of a word, instead of being preWxed or suYxed to the stem. (May 14, 2003 Web edition) InWxes are not at all diYcult to Wnd, however. English-speaking readers will no doubt recognize some, if not all, of the following inWxation constructions: (1) Expletive inWxation (McCarthy 1982) impo´rtant im-bloody-po´rtant fanta´stic fan-fuckin-ta´stic perha´ps per-bloody-ha´ps Kalamazo´o Kalama-goddamn-zo´o Tatamago´uchee Tatama-fuckin-go´uchee (2) Homer-ic inWxation (Yu 2004b) saxophone saxomaphone telephone telemaphone violin viomalin Michaelangelo Michamalangelo (3) Hip-hop iz-inWxation (Viau 2002) house hizouse bitch bizitch soldiers sizoldiers ahead ahizead 2 Introduction Given the relative rarity of inWxes in the world’s languages, it is perhaps not surprising that inWxes are often aVorded a lesser consideration. Yet their richness and complexity have nonetheless captured the imaginations of many linguists. Hidden behind the veil of simplicity implied in the term ‘inWx’, which suggests a sense of uniformity on par with that of preWxes and suYxes, is the diversity of the positions where inWxes are found relative to the stem. -
Computational Analysis of Affixed Words in Malay Language Bali RANAIVO-MALANÇON School of Computer Sciences Universiti Sains Malaysia [email protected]
Computational analysis of affixed words in Malay language Bali RANAIVO-MALANÇON School of Computer Sciences Universiti Sains Malaysia [email protected] A full-system Malay morphological analyser must contain modules that can analyse affixed words, compound words, and reduplicated words. In this paper, we propose an algorithm to analyse automatically Malay affixed words as they appear in a written text by applying successively segmentation, morphographemic, morphotactic, and interpretation rules. To get an accurate analyser, we have classified Malay affixed words into two groups. The first group contains affixed words that cannot be analysed automatically. They are lexicalised affixed words (e.g. berapa, mengapa), idiosyncrasy (e.g. bekerja, penglipur), and infixed words because infixation is not productive any more in Malay language. Affixed words that belong to the first group will be filtered, treated and take off before the segmentation phase. The second group contain affixed words that can be segmented according to segmentation and morphographemic rules. Affixes are classified following their origin (native vs. borrowed), their position in relation to the base (prefix, suffix, circumfix), and the spelling variations they may create when they are added to a base. At the moment, the analyser can process affixed words containing only native prefixes, suffixes and circumfixes. In Malay language, only five native prefixes (ber-, per-, ter-, me-, pe-) may create some modification (deletion, insertion, assimilation) at the point of contact with the base. Thus the main problem in segmenting prefixed words in Malay is to determine the end of the prefix and the beginning of the base. To solve the problem, we state that each affix in Malay has only one form (i.e. -
Immune Regulation by CD52-Expressing CD4 T Cells
Cellular & Molecular Immunology (2013) 10, 379–382 ß 2013 CSI and USTC. All rights reserved 1672-7681/13 $32.00 www.nature.com/cmi RESEARCH HIGHLIGHT Immune regulation by CD52-expressing CD4 T cells Ban-Hock Toh1, Tin Kyaw1,2, Peter Tipping1 and Alex Bobik2 T-cell regulation by CD52-expressing CD4 T cells appears to operate by two different and possibly synergistic mechanisms. The first is by its release from the cell surface of CD4 T cells that express high levels of CD52 that then binds to the inhibitory sialic acid-binding immunoglobulin-like lectins-10 (Siglec-10) receptor to attenuate effector T-cell activation by impairing phosphorylation of T-cell receptor associated lck and zap-70. The second mechanism appears to be by crosslinkage of the CD52 molecules by an as yet unidentified endogenous ligand that is mimicked by a bivalent anti-CD52 antibody that results in their expansion. Cellular & Molecular Immunology (2013) 10, 379–382; doi:10.1038/cmi.2013.35; published online 12 August 2013 he immune system is designed to appears in the affirmative, and includes suppression was lost by cleavage of N- T protect its host from invading players such as IL-10-secreting Tr1 and glycans from CD52-Fc by peptide N- pathogens and yet remain non-reactive TGF-b-secreting Th3. cells. Absence of glycosidase or by removal of sialic acid to self. Immunological homeostasis is surface markers limited the usefulness residues by neuraminidase. Suppression maintained by purging self-reactive lym- of these other regulators. However, the was also blocked by antibody to the phocytes by clonal deletion coupled with recent report that CD49b and lympho- extracellular domain of Siglec-10 and a regulatory population of lymphocytes cyte activation gene-3 are highly and sta- by soluble Siglec-10-Fc. -
Conditional Tenses: -Nge-, -Ngali- and -Ki- Tenses and Their Negations
Chapter 32 Conditional Tenses: -nge-, -ngali- and -ki- Tenses and Their Negations n this chapter, we will learn how to use conditional tenses: the -nge-, I-ngali- and -ki- tenses. These tenses indicate a condition, hypothesis or an assumption. The -nge- tense shows a condition in the present tense eg: If I were to study, etc. while the -ngali- tense shows a condition in the past tense eg: If I had studied, etc. We will also discuss the -ki- tense which shows a condition in the present tense which has future implica- tions eg: If I study, etc. Also, the word kama can be used with both the affirmative and negative conditional tenses to emphasize the conditional- ity. In addition, the -ki- tense can also be used as a present participle tense which will also be discussed in this chapter. Note that in conditional clauses, past tense shows a present condi- tion, a past perfect tense shows a past condition while a present tense shows a future condition. Section A: -nge- Tense The -nge- tense is used to show a hypothesis in the present tense. Similar to other tense markers, sentences using -nge- tense markers are con- structed in the following manner. Subject Prefix + -nge- Tense Marker + Verb Copyright © 2014. UPA. All rights reserved. © 2014. UPA. All rights Copyright Example: Ningesoma vizuri, ningefaulu. If I were to study well, I would pass. Almasi, Oswald, et al. <i>Swahili Grammar for Introductory and Intermediate Levels : Sarufi ya Kiswahili cha Ngazi ya Kwanza na Kati</i>, UPA, 2014. ProQuest Ebook Central, http://ebookcentral.proquest.com/lib/hselibrary-ebooks/detail.action?docID=1810394. -
Greek and Latin Roots, Prefixes, and Suffixes
GREEK AND LATIN ROOTS, PREFIXES, AND SUFFIXES This is a resource pack that I put together for myself to teach roots, prefixes, and suffixes as part of a separate vocabulary class (short weekly sessions). It is a combination of helpful resources that I have found on the web as well as some tips of my own (such as the simple lesson plan). Lesson Plan Ideas ........................................................................................................... 3 Simple Lesson Plan for Word Study: ........................................................................... 3 Lesson Plan Idea 2 ...................................................................................................... 3 Background Information .................................................................................................. 5 Why Study Word Roots, Prefixes, and Suffixes? ......................................................... 6 Latin and Greek Word Elements .............................................................................. 6 Latin Roots, Prefixes, and Suffixes .......................................................................... 6 Root, Prefix, and Suffix Lists ........................................................................................... 8 List 1: MEGA root list ................................................................................................... 9 List 2: Roots, Prefixes, and Suffixes .......................................................................... 32 List 3: Prefix List ...................................................................................................... -
Monoclonal Antibody Playbook
Federal Response to COVID-19: Monoclonal Antibody Clinical Implementation Guide Outpatient administration guide for healthcare providers 2 SEPTEMBER 2021 1 Introduction to COVID-19 Monoclonal Antibody Therapy 2 Overview of Emergency Use Authorizations 3 Site and Patient Logistics Site preparation Patient pathways to monoclonal administration 4 Team Roles and Responsibilities Leadership Administrative Clinical Table of 5 Monoclonal Antibody Indications and Administration Indications Contents Preparation Administration Response to adverse events 6 Supplies and Resources Infrastructure Administrative Patient Intake Administration 7 Examples: Sites of Administration and Staffing Patterns 8 Additional Resources 1 1. Introduction to Monoclonal Therapy 2 As of 08/13/21 Summary of COVID-19 Therapeutics 1 • No Illness . Health, no infections • Exposed Asymptomatic Infected . Scope of this Implementation Guide . Not hospitalized, no limitations . Monoclonal Antibodies for post-exposure prophylaxis (Casirivimab + Imdevimab (RGN)) – EUA Issued. • Early Symptomatic . Scope of this Implementation Guide . Not hospitalized, with limitations . Monoclonal Antibodies for treatment (EUA issued): Bamlanivimab + Etesevimab1 (Lilly) Casirivimab + Imdevimab (RGN) Sotrovimab (GSK/Vir) • Hospital Adminission. Treated with Remdesivir (FDA Approved) or Tocilizumab (EUA Issued) . Hospitalized, no acute medical problems . Hospitalized, not on oxygen . Hospitlaized, on oxygen • ICU Admission . Hospitalized, high flow oxygen, non-invasive ventilation -
REGENERON PHARMACEUTICALS, INC. (Exact Name of Registrant As Specified in Charter)
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 9, 2017 (February 9, 2017) REGENERON PHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in Charter) New York 000-19034 13-3444607 (State or other jurisdiction (Commission (IRS Employer of Incorporation) File No.) Identification No.) 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707 (Address of principal executive offices, including zip code) (914) 847-7000 (Registrant's telephone number, including area code) Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: ☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) Item 2.02 Results of Operations and Financial Condition. On February 9, 2017, Regeneron Pharmaceuticals, Inc. issued a press release announcing its financial and operating results for the quarter and year ended December 31, 2016. A copy of the press release is being furnished to the Securities and Exchange Commission as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated by reference to this Item 2.02. -
The Aslian Languages of Malaysia and Thailand: an Assessment
Language Documentation and Description ISSN 1740-6234 ___________________________________________ This article appears in: Language Documentation and Description, vol 11. Editors: Stuart McGill & Peter K. Austin The Aslian languages of Malaysia and Thailand: an assessment GEOFFREY BENJAMIN Cite this article: Geoffrey Benjamin (2012). The Aslian languages of Malaysia and Thailand: an assessment. In Stuart McGill & Peter K. Austin (eds) Language Documentation and Description, vol 11. London: SOAS. pp. 136-230 Link to this article: http://www.elpublishing.org/PID/131 This electronic version first published: July 2014 __________________________________________________ This article is published under a Creative Commons License CC-BY-NC (Attribution-NonCommercial). The licence permits users to use, reproduce, disseminate or display the article provided that the author is attributed as the original creator and that the reuse is restricted to non-commercial purposes i.e. research or educational use. See http://creativecommons.org/licenses/by-nc/4.0/ ______________________________________________________ EL Publishing For more EL Publishing articles and services: Website: http://www.elpublishing.org Terms of use: http://www.elpublishing.org/terms Submissions: http://www.elpublishing.org/submissions The Aslian languages of Malaysia and Thailand: an assessment Geoffrey Benjamin Nanyang Technological University and Institute of Southeast Asian Studies, Singapore 1. Introduction1 The term ‘Aslian’ refers to a distinctive group of approximately 20 Mon- Khmer languages spoken in Peninsular Malaysia and the isthmian parts of southern Thailand.2 All the Aslian-speakers belong to the tribal or formerly- 1 This paper has undergone several transformations. The earliest version was presented at the Workshop on Endangered Languages and Literatures of Southeast Asia, Royal Institute of Linguistics and Anthropology, Leiden, in December 1996. -
The Future of Antibodies As Cancer Drugs
REVIEWS Drug Discovery Today Volume 17, Numbers 17/18 September 2012 The biopharmaceutical industry’s pipeline of anticancer antibodies includes 165 candidates with substantial diversity in composition, targets and mechanisms of action that hold promise to be the cancer drugs of the future. Reviews FOUNDATION REVIEW Foundation review: The future of antibodies as cancer drugs 1 2 Dr Janice Reichert Janice M. Reichert and Eugen Dhimolea is Research Assistant Professor at Tufts 1 Center for the Study of Drug Development, Tufts University School of Medicine, 75 Kneeland Street, University’s Center for the Study of Drug Development Suite 1100, Boston, MA 02111, USA 2 (CSDD). She is also Founder Department of Medical Oncology, Dana-Farber Cancer Institute/Harvard Medical School, 77 Louis Pasteur Ave., and Editor-in-Chief of mAbs, Harvard Institutes of Medicine, Room 309, Boston, MA 02215, USA a peer-reviewed, PubMed- indexed biomedical journal that focuses on topics relevant to antibody research Targeted therapeutics such as monoclonal antibodies (mAbs) have proven and development; President of the board of directors of The Antibody Society; and a member of the board successful as cancer drugs. To profile products that could be marketed in of the Peptide Therapeutics Foundation. At CSDD, the future, we examined the current commercial clinical pipeline of mAb Dr Reichert studies innovation in the pharmaceutical and biotechnology industries. Her work focuses on candidates for cancer. Our analysis revealed trends toward development of strategic analyses of investigational candidates and marketed products, with an emphasis on the clinical a variety of noncanonical mAbs, including antibody–drug conjugates development and approval of new therapeutics and (ADCs), bispecific antibodies, engineered antibodies and antibody vaccines. -
Types and Functions of Reduplication in Palembang
Journal of the Southeast Asian Linguistics Society JSEALS 12.1 (2019): 113-142 ISSN: 1836-6821, DOI: http://hdl.handle.net/10524/52447 University of Hawaiʼi Press TYPES AND FUNCTIONS OF REDUPLICATION IN PALEMBANG Mardheya Alsamadani & Samar Taibah Wayne State University [email protected] & [email protected] Abstract In this paper, we study the morphosemantic aspects of reduplication in Palembang (also known as Musi). In Palembang, both content and function words undergo reduplication, generating a wide variety of semantic functions, such as pluralization, iteration, distribution, and nominalization. Productive reduplication includes full reduplication and reduplication plus affixation, while fossilized reduplication includes partial reduplication and rhyming reduplication. We employed the Distributed Morphology theory (DM) (Halle and Marantz 1993, 1994) to account for these different patterns of reduplication. Moreover, we compared the functions of Palembang reduplication to those of Malay and Indonesian reduplication. Some instances of function word reduplication in Palembang were not found in these languages, such as reduplication of question words and reduplication of negators. In addition, Palembang partial reduplication is fossilized, with only a few examples collected. In contrast, Malay partial reduplication is productive and utilized to create new words, especially words borrowed from English (Ahmad 2005). Keywords: Reduplication, affixation, Palembang/Musi, morphosemantics ISO 639-3 codes: mui 1 Introduction This paper has three purposes. The first is to document the reduplication patterns found in Palembang based on the data collected from three Palembang native speakers. Second, we aim to illustrate some shared features of Palembang reduplication with those found in other Malayic languages such as Indonesian and Malay. The third purpose is to provide a formal analysis of Palembang reduplication based on the Distributed Morphology Theory. -
CYRAMZA (Ramucirumab) Injection Label
1 HIGHLIGHTS OF PRESCRIBING INFORMATION • 500 mg/50 mL (10 mg per mL) solution, single-dose vial (3) These highlights do not include all the information needed to use CYRAMZA safely and effectively. See full prescribing information ------------------------------- CONTRAINDICATIONS ------------------------------ for CYRAMZA. None CYRAMZA (ramucirumab) injection, for intravenous infusion ------------------------ WARNINGS AND PRECAUTIONS ----------------------- Initial U.S. Approval: 2014 • Arterial Thromboembolic Events (ATEs): Serious, sometimes fatal WARNING: HEMORRHAGE ATEs have been reported in clinical trials. Discontinue CYRAMZA for severe ATEs. (5.2) See full prescribing information for complete boxed warning. • Hypertension: Monitor blood pressure and treat hypertension. CYRAMZA increased the risk of hemorrhage, including severe Temporarily suspend CYRAMZA for severe hypertension. and sometimes fatal hemorrhagic events. Permanently Discontinue CYRAMZA for hypertension that cannot be medically discontinue CYRAMZA in patients who experience severe controlled. (5.3) bleeding [see Dosage and Administration (2.3), Warnings and • Infusion-Related Reactions: Monitor for signs and symptoms Precautions (5.1)]. during infusion. (5.4) • Gastrointestinal Perforation: Discontinue CYRAMZA. (5.5) --------------------------- RECENT MAJOR CHANGES -------------------------- • Impaired Wound Healing: Withhold CYRAMZA prior to surgery. Indications and Usage 11/2014 (5.6) • Clinical Deterioration in Patients with Cirrhosis: New onset or Dosage and Administration: -
COVID-19 Immunotherapy: Novel Humanized 47D11 Monoclonal Antibody
Review Article ISSN: 2574 -1241 DOI: 10.26717/BJSTR.2020.29.004828 COVID-19 Immunotherapy: Novel Humanized 47D11 Monoclonal Antibody Basma H Marghani* Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Egypt *Corresponding author: Basma H Marghani, Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Egypt ARTICLE INFO ABSTRACT Received: August 10, 2020 Published: August 18, 2020 rapidly to the other countries all over the world, caused a novel Coronavirus-2019 (COV- SARS-CoV-2 was appeared firstly in Wuhan, China in December 2019, then spread- gency. After infection, virus entry the host cell through spike proteins (S)- angiotensin Citation: Basma H Marghani. COVID-19 ID-19). The World Health Organization was branded COVID-19 as a global health emer Immunotherapy: Novel Humanized 47D11 converting enzyme 2 (ACE2) cell membrane receptor via their S-Binding domain, then Monoclonal Antibody. Biomed J Sci & Tech virus replication caused acute respiratory disease syndrome (ARDS). Till now there was Res 29(4)-2020. BJSTR. MS.ID.004828. no vaccines or anti-viral drugs for coronavirus infection. One effective treatment is the use of human monoclonal antibodies (mAbs) which are engineered to target and block Keywords: COVID-19; Immunotherapy; cell surface receptor. mAbs could be given to people in the early stages of COVID-19 as a Full-Length Humanized Monoclonal Anti- therapeutic, or used prophylactically to give immediate, long-term immunity to vulnera- bodies; ACE Inhibitor ble people such as healthcare workers. The neutralizing humanized 47D11 monoclonal antibody targets a common epitope on SARS-CoV2 virus and may offer potential for pre- Abbreviations: ACE2: Angiotensin-Con- vention and treatment of COVID-19.89U (Graphical Abstract 1).