DOCSLIB.ORG

Clinical Medicine Covertemplate

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Clinical Medicine Covertemplate Matthew P. Lungren Michael R.B. Evans Editors TreatmentClinical Medicine Resistance inCove Psychiatryrtemplate RiskSubtitle Factors, for Biology, and ManagementClinical Medicine Covers T3_HB Yong-KuSecond Ed Kimition Editor 123123 Treatment Resistance in Psychiatry Yong-Ku Kim Editor Treatment Resistance in Psychiatry Risk Factors, Biology, and Management Editor Yong-Ku Kim Department of Psychiatry College of Medicine, Korea University Seoul South Korea ISBN 978-981-10-4357-4 ISBN 978-981-10-4358-1 (eBook) https://doi.org/10.1007/978-981-10-4358-1 Library of Congress Control Number: 2018957846 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore Preface Despite its great progress in psychopharmacology, a significant proportion of psychiatric patients do not respond satisfactory to the treatment. Given the lack of consistence for defining criteria, it is difficult to assess the accurate prevalence of treatment-resistant psychiatric disorders. Approximately 30% of psychiatric patients would be considered recovered from the standard treatments, 30–40% of patients would be considered improved, whereas 30% of patients would be barely touched by the contemporary treatments. In spite of the fact that there is no full agreement regarding the definition of treatment resistance of psychiatric disorders, treatment resistance clearly refers to the occurrence of an inadequate response following adequate treatment. Coping with the treatment resistance in psychiatric disorders is an important issue facing psychiatrists and their patients. The search of potential biological markers for treatment-resistant psychi- atric disorders is a current challenge in the field of biological psychiatry. One way to fulfill these challenges would be to investigate molecular and cellular causes responsible for the treatment resistance using blood and cerebrospinal fluid analysis, neuroimaging, and genetic and epigenetic techniques. Then, obtained biological markers would be used for developing clinical risk fac- tors for treatment resistance and for delivering effective treatments to reach complete remission of symptoms. However, the goal is presently out of reach. Therefore, we need to think outside the box and get away from conventional ways of thinking. Post hoc experimental design can be regarded only as a consequence of having treatment-resistance, rather than being causal risk factors for it. So, we need a paradigm shift toward cause-and-effect relationship. Our lack of information on treatment resistance can start with the misinterpreted post hoc design of many studies. To deal with this situation, untreated patients are enrolled in the study to identify biological markers for treatment resistance. This book reviews all the important aspects of treatment-resistant psychi- atric disorders, covering issues such as definitions, clinical aspects, neurobio- logical correlates, treatment options, and predictors of treatment response. The book is divided into three parts, the first (Chaps. 1, 2, 3, 4, 5, and 6) of which examines the most recent thinking on treatment resistance in psychia- try, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or func- tional connectivity, and insights from animal models. The second (Chaps. 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, and 18) part then discusses treatment v vi Preface resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, in third (Chaps. 19, 20, 21, 22, 23, 24, and 25) part, more detailed information is presented on diverse pharmacological and nonphar- macological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of man- agement for treatment resistance in psychiatric disorders. Chapter 1 highlights a current and available knowledge about definition, epidemiology, risk factors, and improving strategies of treatment resistance in mental disorders. The definition of treatment resistance in psychiatry remains controversial in spite of importance. Most definitions have focused on pharmacotherapy but even these have struggled to capture the complexity of varying response and duration of treatment. This review discusses the importance of treatment resistance and factors affecting its definition in the light of recent advances in knowledge and treatment. The optimization of treatment, such as personalized medicine, measurement-based care, combi- nation and augmentation strategies and experimental treatment strategies, diminishes the occurrence of treatment resistance. Chapter 2 reviews some methodological considerations to uncover initial risk factors for treatment-resistant psychiatric disorders and propose a better study design for future research by discussing the shortcomings of traditional study design. The post hoc experimental design can be regarded only as a consequence of having treatment resistance, rather than being causal risk fac- tors for it. Data derived from such studies often do not allow for a distinction to be made between cause and effect. To deal with this problem, untreated patients should be enrolled in the study to identify biological markers for treatment resistance. Such information can give a cue to improve the initial diagnosis and provide more effective treatment for treatment resistance. Chapter 3 focuses on clinical evidences from pharmacogenetic or pharma- cogenomic data in major psychiatric disorders in order to better understand potential biomarkers that can be aid in the prediction of therapeutic response. Although the search for genetic biomarkers is facilitated by several approaches including epidemiological studies, molecular methods, genome-wide associ- ation studies, transcriptional and microRNA analyses, gene-environment interaction, and epigenetic approaches, no biomarkers have good enough sen- sitivity and specificity to be applied in clinical practice at present. The major- ity of available pharmacogenetic studies in psychiatry refers to how a specific gene or a set of genes can influence a patient’s response or side effects and only few of them are specifically designed to explore biomarkers underlying treatment resistance. Chapter 4 illustrates recent study findings regarding clinical application of brain-based biomarkers derived from patients for the prediction of response or resistance to treatment, as well as for improved design of clinical studies, to find more robust brain-based biomarkers of treatment response or resis- tance. Earlier identification of patients who are prone to treatment resistance can avoid the frustration of a trial-and-error approach and facilitate the design of more optimized treatment regimens and setting of individualized levels of Preface vii care. In future, more active application of machine-learning and medical bio- informatics frameworks to the brain biomarker-based prediction of treatment response and recommendation of a personalized treatment regimen are warranted. Chapter 5 suggests ways to develop new drugs that may be effective in the treatment of resistant depression. Animal models of depression have been developed with a focus on those likely to demonstrate useful drugs in resis- tant depression or associations. Are there animal models for resistant depres- sion? Researchers have proposed models likely to develop drugs that can treat resistant depression. A potential model to discover antidepressants active in resistant depression is based on genetic. To date, the genetic model has not been used in the development of treatments for resistant depression, but it is a path that seems interesting. Chapter 6 highlights the hypothetical conceptualization of an integrated approach to treatment-resistant psychiatric disorders. The integrated approaches for treatment-resistant psychiatric disorders can be an important issue in the perspective of clinical psychiatry. The synergistic
Load more

Recommended publications
  • Year in Review 2018/2019
    Contents Shaping the Museum of the Future 2 Philanthropy on View 4 The Year at a Glance 8 Compelling Mix of Original and Touring Exhibitions 12 ROM Objects on Loan Locally and Globally 26 Leading-Edge Research 36 ROM Scholarship in Print 46 Community Connections 50 Access to First Peoples Art and Culture 58 Programming That Inspires 60 Learning at the ROM 66 Members and Volunteers 70 Digital Readiness 72 Philanthropy 74 ROM Leadership 80 Our Supporters 86 2 royal ontario museum year in review 2018–2019 3 One of the initiatives we were most proud of in 2018 was the opening of the Daphne Cockwell Gallery dedicated to First Peoples art & culture as free to the public every day the Museum is open. Initiatives such as this represent just one step on our journey. ROM programs and exhibitions continue to be bold, ambitious, and diverse, fostering discourse at home and around the world. Being Japanese Canadian: reflections on a broken world, Gods in My Home: Chinese New Year with Ancestor Portraits and Deity Prints and The Evidence Room helped ROM visitors connect past to present and understand forces and influences that have shaped our world, while #MeToo & the Arts brought forward a critical conversation about the arts, institutions, and cultural movements. Immersive and interactive exhibitions such as aptured in these pages is a pivotal Zuul: Life of an Armoured Dinosaur and Spiders: year for the Royal Ontario Museum. Fear & Fascination showcased groundbreaking Shaping Not only did the Museum’s robust ROM research and world-class storytelling. The Cattendance of 1.34 million visitors contribute to success achieved with these exhibitions set the our ranking as the #1 most-visited museum in stage for upcoming ROM-originals Bloodsuckers: the Canada and #7 in North America according to The Legends to Leeches, The Cloth That Changed the Art Newspaper, but a new report by Deloitte shows World: India’s Painted and Printed Cottons, and the the ROM, through its various activities, contributed busy slate of art, culture, and nature ahead.
    [Show full text]
  • Booking-Guide-2015 Final.Pdf
    04_Welcomes Unsound Adelaide 50_Lawrence English, Container, THEATRE 20_Azimut Vatican Shadow, Fushitsusha BOLD, INNOVATIVE FESTIVAL 26_riverrun 51_Atom™ and Robin Fox, Forest Swords, 28_Nufonia Must Fall The Bug, Shackleton SEEKS LIKE-MINDED FRIENDS 30_Black Diggers 51_Model 500, Mika Vainio, Evian Christ, 36_Beauty and the Beast Hieroglyphic Being 38_La Merda 52_Mogwai Become a Friend to receive: 40_The Cardinals 53_The Pop Group 15% discount 41_Dylan Thomas—Return Journey 54_Vampillia 42_Beckett Triptych 55_65daysofstatic Priority seating 43_SmallWaR 56_Soundpond.net Late Sessions And much more 44_Jack and the Beanstalk 57_The Experiment 58_Late Night in the Cathedral: Passio DANCE Cedar Lake Contemporary Ballet 59_Remember Tomorrow DISCOVER THE DETAILS 16_Mixed Rep 60_House of Dreams PAGE 70 OR VISIT ADELAIDEFESTIVAL.COM.AU 18_Orbo Novo 61_WOMADelaide VISUAL 06_Blinc ADELAIDE 62_Adelaide Writers’ Week ARTS 10_Bill Viola: Selected Works WRITERS’ 66_The Third Plate: Dan Barber 68_Trent Parke: The Black Rose WEEK 67_Kids’ Weekend MUSIC 14_Danny Elfman’s Music from the MORE 70_Bookings Films of Tim Burton 71_Schools 72_Access Gavin Bryars in Residence 73_Map 23_Marilyn Forever 74_Staff 24_Gavin Bryars Ensemble 75_Supporters and Philanthropy 24_Gavin Bryars Ensemble with guests 84_Corporate Hospitality 25_Jesus’ Blood Never Failed Me Yet and selected orchestral works FOLD OUT 84_Calendar 32_Fela! The Concert 34_Tommy 46_Blow the Bloody Doors Off!! Join us online 48_Abdullah Ibrahim 49_Richard Thompson Electric Trio #ADLFEST #ADLWW ADELAIDEFESTIVAL.COM.AU −03 Jay Weatherill Jack Snelling David Sefton PREMIER OF SOUTH AUSTRALIA MINISTER FOR THE ARTS ARTISTIC DIRECTOR Welcome to the 30th Adelaide Festival of Arts. The 2015 Adelaide Festival of Arts will please Greetings! It is my privilege and pleasure to In the performance program there is a huge range arts lovers everywhere with its broad program present to you the 2015 Adelaide Festival of Arts.
    [Show full text]
  • Everfarm® − Climate Adapted Perennial-Based Farming Systems
    ® Everfarm − Climate adapted perennial-based farming systems for dryland agriculture in southern Australia Final Report Robert Farquharson, Amir Abadi, John Finlayson, Thiagarajah Ramilan, De Li Lui, Muhuddin Anwar, Steve Clark, Susan Robertson, Daniel Mendham, Quenten Thomas and John McGrath EverFarm® – Climate adapted perennial-based farming systems for dryland agriculture in southern Australia Robert Farquharson1, Amir Abadi 2, John Finlayson3, Thiagarajah Ramilan1, De Li Liu4, Muhuddin R Anwar 4, Steve Clark5, Susan Robertson6, Daniel Mendham7, Quenten Thomas8 and John McGrath9 1 Future Farm Industries Cooperative Research Centre and University of Melbourne 2 Future Farm Industries Cooperative Research Centre and Western Australian Department of Environment and Conservation 3 Future Farm Industries Cooperative Research Centre and University of Western Australia 4 New South Wales Department of Primary Industries 5 Victorian Department of Primary Industries 6 Charles Sturt University 7 Future Farm Industries Cooperative Research Centre and CSIRO Ecosystem Sciences 8 Quisitive Pty Ltd 9 Future Farm Industries Cooperative Research Centre May 2013 A project report funded by the National Climate Change Adaptation Research Facility and the Future Farm Industries Cooperative Research Centre Published by the National Climate Change Adaptation Research Facility ISBN: 978-1-925039-66-5 NCCARF Publication 95/13 © 2013 Future Farm Industries Cooperative Research Centre This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part may be reproduced by any process without prior written permission from the copyright holder. Please cite this report as: Farquharson, R, Abadi, A, Finlayson, J, Ramilan, T, Liu, DL, Anwar, MR, Clark, S, Robertson, S, Mendham, D, Thomas, Q & McGrath, J 2013, EverFarm® – Climate adapted perennial-based farming systems for dryland agriculture in southern Australia, National Climate Change Adaptation Research Facility, Gold Coast, 147 pp.
    [Show full text]
  • Congressional Record-Senate. April 22
    . 3512 CONGRESSIONAL RECORD-SENATE. APRIL 22, By Mr. GRISWOLD: Petition of citizens of Erie, Pa., for the By Mr. STEPHENSON: Petitionof David Wood and 15other passage of House bill401 in regard to immigration and importa­ church members and 62 other signers, of Alma, Mich., to close tion of aliens-to the Select Committee on Immigration and Nat­ the Columbian Exposition on Sunday-to the Select Committee uralization. on the Columbian Exposition. By Mr. HARMER: Petition of John S. Walter, late second By Mr. JOSEPH D. TAYLOR: Memorial.of Lindlay M. Fullis lieutenant of Company B, Thirteenth Regim<;)nt Volunteer Cav­ Post, No. 123, Grand Army of the Republic, of Ohio, signed by 32 alry of Pennsylvania-to the Committee on Military Affairs. members thereof, praying for legislation preserving and mark­ By Mr. HARTER: Petition of the National Philatelical Soci­ ing the lines of Gettysburg battlefield -to the Committee on ety, to place postage stamps on the free list-to the Committee Military Affairs. on Ways and Means. Also, two petitions of citizens of Ohio, one of Columbiana, hav­ By Mr. HATCH: Two protests.of Farmers and Laborers.' Un­ ing 220 signatures, and the other, of Jefferson County, having ion of Missouri, one of Macon County and the other of Adair 180 signatures, praying for the passage of House bill 401, intro­ County, protesting against the passage of the Brosius lard bill duced by Hon. WILLIAM A. STONE, of Pennsylvania-to theSe­ (H. R. 395), and praying for the passage of a general pure-food lect Committee on Immigration and Naturalization.
    [Show full text]
  • Genre Flash 5.Pmd
    Genre Flash5 THE BEST A USTRALIAN GENRE FICTION & TRUE CRIME A Whole World of Fiction CRIME ~ MYSTERIES ~ THRILLERS and a little bit of fact SF ~ SCIENCE & SPECULATIVE FICTION FANTASY ~ HORROR SUMMER 2011 INSIDE Genre Flash5 The lastest and the best in Australian genre fiction and true crime. Feature articles: on Kerry Greenwood by Kylie Fox; on Shadow by David Greagg; on cross-genre writing by Marianne de Pierres; and on history repeating by Lindy Cameron. Genre Fiction Egypt in the 18th Dynasty is peaceful and prosperous under the dual reign of father and son pharaohs Amenhotep III and IV, until the son begins to dream terrifying dreams. Ptah-hotep, a peasant boy studying to be a scribe, wants to live a simple life in a Nile hut with his lover Kheperren and their dog Wolf, but the younger pharaoh appoints him as his Great Royal Scribe. Surrounded by envious rivals, how long will Ptah-hotep survive? Child-princess Mutnodjme sees her beautiful sister Nefertiti married off to the impotent Amenhotep IV. As she must still bear royal children, a shocking plan is devised. Kheperren leaves to serve as scribe to the daring teenage General Horemheb. But, while the shrinking Egyptian army guards the Land of the Nile from enemies on every border, a far greater menace impends. For, not content with his own devotion to one god alone, the young newly-renamed Akhnaten intends to suppress the worship of all other gods in the Black Land. His horrified court soon realise that the Pharaoh is not merely deformed, but irretrievably mad; and that the biggest danger to the Empire is in the royal palace itself.
    [Show full text]
  • ANNUAL REPORT 2018–19 NATIONAL LIBRARY of AUSTRALIA Annual Report 2018–19
    2018–19 Annual Report Report Annual NATIONAL LIBRARY OF AUSTRALIA OF AUSTRALIA LIBRARY NATIONAL ANNUAL REPORT 2018–19 NATIONAL LIBRARY OF AUSTRALIA GOVERNANCE AND ACCOUNTABILTY i NATIONAL LIBRARY OF AUSTRALIA Annual Report 2018–19 NATIONAL LIBRARY OF AUSTRALIA 9 August 2019 The Hon. Paul Fletcher MP Minister for Communications, Cyber Safety and the Arts Parliament House CANBERRA ACT 2600 Dear Minister National Library of Australia Annual Report 2018–19 The Council, as the accountable authority of the National Library of Australia, has pleasure in submitting to you for presentation to each House of Parliament its annual report covering the period 1 July 2018 to 30 June 2019. Published by the National Library of Australia The Council approved this report at its meeting in Canberra on 9 August 2019. Parkes Place Canberra ACT 2600 The report is submitted to you in accordance with section 46 of the T 02 6262 1111 Public Governance, Performance and Accountability Act 2013. F 02 6257 1703 National Relay Service 133 677 We commend the annual report to you. nla.gov.au/policy/annual.html Yours sincerely ABN 28 346 858 075 © National Library of Australia 2019 ISSN 0313-1971 (print) 1443-2269 (online) National Library of Australia The Hon. Dr Brett Mason Dr Marie-Louise Ayres Annual report / National Library of Australia.–8th (1967/68)– Chair of Council Director-General Canberra: NLA, 1968––v.; 25 cm. Annual. Continues: National Library of Australia. Council. Annual report of the Council = ISSN 0069-0082. Report year ends 30 June. ISSN 0313-1971 = Annual report–National Library of Australia.
    [Show full text]
  • 2010-11 Annual Report
    Grants Publications Education Annual Report 2010/11 Victoria Law Foundation Helping Victorians understand the law and use it to improve their lives Contents From the Chair 2 From the Executive Director 4 About Us 6 Our Strategic Priorities in 2010/11 7 The Year at a Glance 8 Strategy One — Reaching out to our community 10 Strategy Two — Engaging students with the law 14 Strategy Three — Better legal information 18 Strategy Four — Best practice grants 22 Strategy Five — Excellence in management 28 Financial Report 31 1 Victoria Law Foundation Annual report 2010/11 From the Chair In the reporting year 1 July 2010 to 30 June 2011 three notable events occurred. First, in November 2010 there was a change in the office of Attorney-General. The previous Attorney-General, the Honourable Rob Hulls MP, was succeeded by the Honourable Robert Clark MP. I pay tribute to the support of the Foundation provided over more than a decade by Mr Hulls. The Foundation acknowledges it and warmly wishes Mr Hulls well. I acknowledge and welcome the support to and interest in the Foundation provided by Mr Clark, shown with readiness since his accession to office. I look forward to working with Mr Clark hereafter and warmly wish him well in the office of Attorney-General. Second, in June 2011, the Victoria Law Foundation Act 2011 came into operation. Essentially it amended the constitution and membership of the Foundation by providing that the Chairperson of the Foundation shall be the Chief Justice or her nominee, and the Foundation shall consist of six members (previously not less than six and not more than eight members).
    [Show full text]
  • Federation of Community Legal Centres Submission to the Royal Commission Into Family Violence
    SUBM.0958.001.0001 June 2015 Federation of Community Legal Centres submission to the Royal Commission into Family Violence Inquiries to: Dr Chris Atmore Senior Policy Adviser Federation of Community Legal Centres (Victoria) Inc 03 9652 1506 [email protected] SUBM.0958.001.0002 About the Federation of Specialist community legal centres focus on groups of people with particular needs or spe- Community Legal cific areas of law (eg mental health, disability, consumer law, environment etc). Centres (Victoria) Inc Community legal centres receive funds and The Federation is the peak body for 50 com- resources from a variety of sources including munity legal centres across Victoria. A full list state, federal and local government, philan- of our members is available at thropic foundations, pro bono contributions http://www.communitylaw.org.au . and donations. Centres also harness the en- ergy and expertise of hundreds of volunteers The Federation leads and supports community across Victoria. legal centres to pursue social equity and to challenge injustice. Community legal centres provide effective and creative solutions to legal problems based on The Federation: their experience within their community. It is • provides information and referrals to our community relationship that distinguishes people seeking legal assistance us from other legal providers and enables us • initiates and resources law reform to to respond effectively to the needs of our develop a fairer legal system that better communities as they arise and change. responds to the needs of the disadvantaged Community legal centres integrate assistance • works to build a stronger and more for individual clients with community legal effective community legal sector education, community development and law • provides services and support to reform projects that are based on client need community legal centres and that are preventative in outcome.
    [Show full text]
  • Domestic Violence Victoria Submission to the Victorian Royal Commission Into Family Violence
    SUBM.0943.001.0001 Considerations for Governance of Family Violence in Victoria Domestic Violence Victoria Submission to the Victorian Royal Commission into Family Violence 19 June 2015 SUBM.0943.001.0002 Acknowledgements DV Vic would like to acknowledge the many women in Victoria who have experienced family violence, and whose courage and determination should be honoured. Enhancing the rights of these women and their children is at the heart of DV Vic’s advocacy for an effective family violence system. DV Vic would also like to acknowledge the work of specialist family violence practitioners in general, and our members in particular. DV Vic members have been extremely generous in sharing their vast experience and thoughtful insights, all of which have informed our submissions and recommendations. SUBM.0943.001.0003 Table of Contents Acknowledgements ............................................................................................................................................................... ii Table of Contents .................................................................................................................................................................. iii About Domestic Violence Victoria (DV Vic) ......................................................................................................................... 1 List of Recommendations ..................................................................................................................................................... 1 Introduction
    [Show full text]
  • Meeting Program
    BOARD OF DIRECTORS Warren K. Bickel, PhD, President William L. Dewey, PhD Chris-Ellyn Johanson, PhD, Past-President Nicholas E. Goeders, PhD Kathryn A. Cunningham, PhD, President-Elect Martin Y. Iguchi, PhD Dorothy K. Hatsukami, PhD, Treasurer Sari Izenwasser, PhD Leslie Amass, PhD Herbert D. Kleber, MD James C. Anthony, PhD Thomas R. Kosten, MD Nancy A. Ator, PhD Horace H. Loh, PhD Anna Rose Childress, PhD S. Stevens Negus, PhD Thomas J. Crowley, MD Sharon Walsh, PhD Samuel A. Deadwyler, PhD EXECUTIVE OFFICER Martin W. Adler, PhD SCIENTIFIC PROGRAM COMMITTEE Sharon Walsh, PhD, Chair Scott E. Lukas, PhD, Past-Chair Martin W. Adler, PhD, ex officio Ellen B. Geller, MA, ex officio Patrick Beardsley, PhD Richard Glennon, PhD Leonard Handelsman, MD Arthur Horton, EdD Sari Izenwasser, PhD Gary B. Kaplan, MD Anthony Liguori, PhD Edythe London, PhD Athina Markou, PhD S. Michael Owens, PhD Linda J. Porrino, PhD Andrew J. Saxon, MD Sandra Welch, PhD Saturday, June 18, 2005 PRE-MEETING SATELLITES The International Study Group Investigating Crown Hall Drugs as Reinforcers (ISGIDAR) Chaired by Michael A. Nader 5 th Annual Meeting Center for Substance Abuse Treatment (CSAT) Great Hall East Science to Services and Services to Science: The Identification and Adoption of Effective Practices for Substance Abuse Treatment Chaired by Karl D. White The 10th Annual NIDA International Forum on England Building International Research on Drug Abuse: Progress through Collaboration Chaired by Steven Gust Translating Basic Research from Neural, Behavioral, Ireland and Social Sciences to Prevention: Challenges and Opportunities Food, Drugs, Obesity and Addiction: Common Scotland C Neurobiologic Processes? Chaired by Nora D.
    [Show full text]
  • This House of Grief Helen Garner ISBN 9781922079206 RRP AUS $32.99 NZ $40.00 Fiction Trade Paperback
    TEXT PUBLISHING Book Club Notes This House of Grief Helen Garner ISBN 9781922079206 RRP AUS $32.99 NZ $40.00 Fiction trade paperback Praise for This House of Grief Cindy Gambino, Farquharson’s ex-wife and mother ‘This House of Grief has all the trademark Helen Garner of the drowned boys, throughout the trial, and her touches: harrowing scenes recorded without restraint experience of the workings of the justice system. or censorship; touching observations of characters’ Garner’s portrayal of the trial and her writing raise weaknesses; wry moments of humour. And also just as many points to talk about: the acuity of her customary with Garner’s work, her words, and the boys’ observations; her interpretation of events and motives fate, will haunt us long after we’ve turned the last page.’ and of the gender politics at play; the tension between Guardian her pity for Farquharson and her conclusion that ‘if ‘This House of Grief is a magnificent book about the there is any doubt that Robert Farquharson drove into majesty of the law and the terrible matter of the human the dam on purpose, it is a doubt no more substantial heart…If you read nothing else this year, read this story than a cigarette paper shivering in the wind, no more of the sorrow and pity of innocents drowned and the reasonable than the unanswered prayer that shot spectres and enigmas of guilt.’ Peter Craven, Australian through my mind when I first saw the photo of the car being dragged from the black water.’ About Helen Garner Questions for discussion Helen Garner was born in 1942 in Geelong.
    [Show full text]
  • ANZSOG Case Program Victoria’S Integrated Family Violence System: from Stalling to Renewal 2015-168.1
    ANZSOG Case Program Victoria’s integrated family violence system: from stalling to renewal 2015-168.1 ‘It was a reforming time’ Nine years after the roll-out of Victoria’s integrated approach to family violence Rachael Green, Manager Policy and Strategy at the Department of Human Services’ (DHS) Office of Women’s Affairs, reflected on the ‘extraordinary’ conditions that led to the $35.1 million service integration reforms. Strong and committed leadership from the Chief Commissioner, the courts and public servants, a reformist Attorney-General, and effective advocacy from the service sector all played a part in the genesis and implementation of a family violence response system that was seen as ‘a model’ for other states. But in 2014, family violence was back on the state (and national) agenda as never before. Incident reporting had skyrocketed, services and courts had become overwhelmed, and despite the best efforts of a dedicated service sector, people were still slipping through the cracks. VicHealth research released in September of that year showed that the prevalence and causes of family violence were still poorly understood by much of the Australian public, and there were in fact some ‘concerning negative findings’.1 This case has been written by Sophie Yates, ANZSOG, for Professor Paul ‘t Hart, ANZSOG and Utrecht University, as a sequel to the case 2009-94.1 Victoria Police and family violence. It has been prepared as a basis for class discussion rather than to illustrate either effective or ineffective handling of a managerial situation. The assistance of Anne Goldsbrough, Rachael Green, Fiona McCormack, Rodney Vlais and members of Victoria Police’s Sexual and Family Violence team is greatly appreciated, but responsibility for the final content rests with ANZSOG.
    [Show full text]