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Adult Congenital Megacolon with Acute Fecal Obstruction and Diabetic Nephropathy: a Case Report
2726 EXPERIMENTAL AND THERAPEUTIC MEDICINE 18: 2726-2730, 2019 Adult congenital megacolon with acute fecal obstruction and diabetic nephropathy: A case report MINGYUAN ZHANG1,2 and KEFENG DING1 1Colorectal Surgery Department, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000; 2Department of Gastrointestinal Surgery, Yinzhou Peoples' Hospital, Ningbo, Zhejiang 315000, P.R. China Received November 27, 2018; Accepted June 20, 2019 DOI: 10.3892/etm.2019.7852 Abstract. Megacolon is a congenital disorder. Adult congen- sufficient amount of bowel should be removed, particularly the ital megacolon (ACM), also known as adult Hirschsprung's aganglionic segment (2). The present study reports on a case of disease, is rare and frequently manifests as constipation. ACM a 56-year-old patient with ACM, fecal impaction and diabetic is caused by the absence of ganglion cells in the submucosa nephropathy. or myenteric plexus of the bowel. Most patients undergo treat- ment of megacolon at a young age, but certain patients cannot Case report be treated until they develop bowel obstruction in adulthood. Bowel obstruction in adults always occurs in complex clinical A 56-year-old male patient with a history of chronic constipa- situations and it is frequently combined with comorbidities, tion presented to the emergency department of Yinzhou including bowel tumors, volvulus, hernias, hypertension or Peoples' Hospital (Ningbo, China) in February 2018. The diabetes mellitus. Surgical intervention is always required in patient had experienced vague abdominal distention for such cases. To avoid recurrence, a sufficient amount of bowel several days. Prior to admission, chronic bowel obstruction should be removed, particularly the aganglionic segment. -
General Principles of GIT Physiology Objectives
General Principles of GIT Physiology Objectives: ❖ Physiologic Anatomy of the Gastrointestinal Wall. ❖ The General & Specific Characteristics of Smooth Muscle. ❖ Neural & Hormonal Control of Gastrointestinal Function. ❖ Types of Neurotransmitters Secreted by Enteric Neurons. ❖ Functional Types of Movements in the GIT. ❖ Gastrointestinal Blood Flow "Splanchnic Circulation". ❖ Effect of Gut Activity and Metabolic Factors on GI Blood Flow. Done by : ➔ Team leader: Rahaf AlShammari ➔ Team members: ◆ Renad AlMigren, Rinad Alghoraiby ◆ Yazeed AlKhayyal, Hesham AlShaya Colour index: ◆ Turki AlShammari, Abdullah AlZaid ● Important ◆ Dana AlKadi, Alanoud AlEssa ● Numbers ◆ Saif AlMeshari, Ahad AlGrain ● Extra َ Abduljabbar AlYamani ◆ َوأن َّل ْي َ َس ِلْ ِْلن َسا ِنَ ِإََّلَ َما َس َع ىَ Gastrointestinal System: GIT Gastrointestinal System Associated Organs (Liver,gallbladder,pancreas,salivary gland) Gastrointestinal Function: ● The alimentary tract provides the body with a continual supply of water, electrolytes, and nutrients. To achieve this function, it requires: 1 Movement of food through the alimentary tract (motility). 2 Secretion of digestive juices and digestion of the food. 3 Absorption of water, various electrolytes, and digestive products. 4 Circulation of blood through the gastrointestinal organs to carry away the absorbed substances. ● Control of all these functions is by local, nervous, and hormonal systems. The Four Processes Carried Out by the GIT: 2 Physiologic Anatomy of the Gastrointestinal Wall ● The following layers structure the GI wall from inner surface outward: ○ The mucosa ○ The submucosa ○ Circular muscle layer ○ longitudinal muscle layer Same layers in Same layers Histology lecture Histology ○ The serosa. ● In addition, sparse bundles of smooth muscle fibers, the mucosal muscle, lie in the deeper layers of the mucosa. The General Characteristics of Smooth Muscle 1- Two Smooth Muscle Classification: Unitary type ● Contracts spontaneously in response to stretch, in the Rich in gap junctions absence of neural or hormonal influence. -
Autonomic Dysfunction in Cystic Fibrosis
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE Supplement No. 43 Volume 96 2003 Autonomic dysfunction in cystic fibrosis AMirakhur MB MRCP MJWalshaw MD FRCP J R Soc Med 2003;96(Suppl. 43):11–17 SECTION OF PAEDIATRICS & CHILD HEALTH, 26 NOVEMBER 2002 INTRODUCTION thetic nervous system, has both pre- and postganglionic The autonomic nervous system (ANS) is a complex neural fibres. However, in general, the preganglionic fibres pass network largely responsible for the regulation of visceral uninterrupted to the organ that is to be controlled; function and maintenance of homeostasis of the internal postganglionic neurons are located in the wall of the organ.3 environment.1 This is achieved primarily through interac- The neurotransmitter for all preganglionic and para- tions with the endocrine system and via autonomic reflexes. sympathetic postganglionic fibres is acetylcholine. All The latter comprise specialized sensory receptors in the postganglionic sympathetic nerves are adrenergic except viscera which provide information regarding visceral for those fibres innervating the sweat glands which are function to higher ANS centres in the brain. At these sites cholinergic.1 sensory information is processed and integrated, and appropriate autonomic motor responses to the viscera are Higher centres relayed through the ANS efferent system. In many The supraspinal integration of ANS function is accomplished circumstances, the ANS reflexes are capable of responding by a complex interaction of many brainstem, mesencephalic very quickly to alterations in the internal environment and and cortical areas, the hypothalamus being the principal can rapidly return the system to its homeostatic baseline. higher centre for integration of ANS function. It receives sensory afferents as well as connections from the limbic GENERAL ANATOMICAL ORGANIZATION system and sensorimotor cortex, and exerts its effects via The ANS has two major divisions: the sympathetic and interactions with the endocrine system and through 2 parasympathetic nervous systems. -
The American Society of Colon and Rectal Surgeons' Clinical Practice
CLINICAL PRACTICE GUIDELINES The American Society of Colon and Rectal Surgeons’ Clinical Practice Guideline for the Evaluation and Management of Constipation Ian M. Paquette, M.D. • Madhulika Varma, M.D. • Charles Ternent, M.D. Genevieve Melton-Meaux, M.D. • Janice F. Rafferty, M.D. • Daniel Feingold, M.D. Scott R. Steele, M.D. he American Society of Colon and Rectal Surgeons for functional constipation include at least 2 of the fol- is dedicated to assuring high-quality patient care lowing symptoms during ≥25% of defecations: straining, Tby advancing the science, prevention, and manage- lumpy or hard stools, sensation of incomplete evacuation, ment of disorders and diseases of the colon, rectum, and sensation of anorectal obstruction or blockage, relying on anus. The Clinical Practice Guidelines Committee is com- manual maneuvers to promote defecation, and having less posed of Society members who are chosen because they than 3 unassisted bowel movements per week.7,8 These cri- XXX have demonstrated expertise in the specialty of colon and teria include constipation related to the 3 common sub- rectal surgery. This committee was created to lead inter- types: colonic inertia or slow transit constipation, normal national efforts in defining quality care for conditions re- transit constipation, and pelvic floor or defecation dys- lated to the colon, rectum, and anus. This is accompanied function. However, in reality, many patients demonstrate by developing Clinical Practice Guidelines based on the symptoms attributable to more than 1 constipation sub- best available evidence. These guidelines are inclusive and type and to constipation-predominant IBS, as well. The not prescriptive. -
Delayed Presentation of a Retained Fecalith
Open Access Case Report DOI: 10.7759/cureus.15919 Delayed Presentation of a Retained Fecalith Fawwad A. Ansari 1 , Muhammad Ibraiz Bilal 1 , Muhammad Umer Riaz Gondal 1 , Mehwish Latif 2 , Nadeem Iqbal 2 1. Medicine, Shifa International Hospital, Islamabad, PAK 2. Gastroenterology, Shifa International Hospital, Islamabad, PAK Corresponding author: Fawwad A. Ansari, [email protected] Abstract A fecalith is a common cause of acute appendicitis, and laparoscopic surgery is the mainstay of its management. Literature review shows that a fecalith may be retained in the gut following a laparoscopic appendectomy in some rare cases. In most cases, the fecalith becomes symptomatic with time due to the formation of an abscess, fistulous tract, or inflammation of the appendicular stump (stump appendicitis). We report a case of retained appendicular fecalith presenting with symptoms similar to acute appendicitis, 15 years after laparoscopic appendectomy. Categories: Gastroenterology, General Surgery Keywords: colonoscopy, acute appendicitis, appendectomy, fecalith, right iliac fossa pain, complications Introduction A fecalith is a hard stony mass of feces in the intestinal tract. Fecal impaction occurs when a large amount of fecal matter gets compacted and cannot get evacuated spontaneously [1]. In its extreme form, fecal impaction can lead to the formation of a fecalith due to the hardening of fecal material that forms a mass separate from other bowel contents [2]. It can occur in any part of the intestine [1]. Most often, a fecalith arises in the colon (mostly sigmoid) or rectum and very rarely in the small intestine [2]. Here we present a case of a retained appendicular fecalith in a patient who presented with an acute abdomen. -
Gastroenterology and the Elderly
3 Gastroenterology and the Elderly Thomas W. Sheehy 3.1. Esophagus 3.1.1. Dysphagia Esophageal disorders, such as esophageal motility disorders, infections, tumors, and other diseases, are common in the elderly. In the elderly, dysphagia usually implies organic disease. There are two types: (1) pre-esophageal and (2) esophageal. Both are further subdivided into motor (neuromuscular) or structural (intrinsic and extrinsic) lesions.! 3.1.2. Pre-esophageal Dysphagia Pre-esophageal dysphagia (PED) usually implies neuromuscular disease and may be caused by pseudobular palsy, multiple sclerosis, amy trophic lateral scle rosis, Parkinson's disease, bulbar poliomyelitis, lesions of the glossopharyngeal nerve, myasthenia gravis, and muscular dystrophies. Since PED is due to inability to initiate the swallowing mechanism, food cannot escape from the oropharynx into the esophagus. Such patients usually have more difficulty swallowing liquid THOMAS W. SHEEHY • The University of Alabama in Birmingham, School of Medicine, Department of Medicine; and Medical Services, Veterans Administration Medical Center, Birming ham, Alabama 35233. 87 S. R. Gambert (ed.), Contemporary Geriatric Medicine © Plenum Publishing Corporation 1983 88 THOMAS W. SHEEHY than solids. They sputter or cough during attempts to swallow and often have nasal regurgitation or aspiration of food. 3.1.3. Dysfunction of the Cricopharyngeus Muscle In the elderly, this is one of the more common forms of PED.2 These patients have the sensation of an obstruction in their throat when they attempt to swallow. This is due to incoordination of the cricopharyngeus muscle. When this muscle fails to relax quickly enough during swallowing, food cannot pass freely into the esophagus. If the muscle relaxes promptly but closes too quickly, food is trapped as it attempts to enter the esophagus. -
Current Strategies in the Management of Irritable Bowel Syndrome
icine- O ed pe M n l A a c n c r e e s t s n I Internal Medicine: Open Access Randall et al., Intern Med 2014, S1:006 DOI: 10.4172/2165-8048.S1-006 ISSN: 2165-8048 Review Article Open Access Current Strategies in the Management of Irritable Bowel Syndrome Randall CW1,2*, Saurez AV3 and Zaga-Galante J3 1Clinical Professor of Medicine, University of Texas Health Science Ctr, San Antonio, USA 2CEO, Gastroenterology Research of America, USA 3Anahuac University, Mexico City, Mexico *Corresponding author: Charles W Randall, Clinical Professor of Medicine, University of Texas Health Science Ctr, San Antonio, USA and CEO, Gastroenterology Research of America, USA, Tel: (210) 410 2515; E-mail: [email protected] Rec date: Jan 17, 2014, Acc date: Feb 28, 2014, Pub date: Mar 09, 2014 Copyright: ©2014 Randall CW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Irritable bowel syndrome (IBS) is one of the most studied and discussed problems in the field of gastroenterology, yet it often remains perplexing to both clinicians and patients. Some of the apprehension comes from a void of objective data that defines a diagnosis in most disorders. This level of comfort is not appreciated in the evaluation of IBS, where the art of medicine and subjective impressions are the cornerstones of proper assessment. Though this paper focuses on management, a review of pathophysiology and specific guidelines establishing a diagnosis of IBS will be addressed. -
Case Studies of Two Cystic Fibrosis Patients with Distal Intestinal Obstruction Syndrome (DIOS) and a Literature Review
Case report Case Studies of Two Cystic Fibrosis Patients with distal intestinal obstruction syndrome (DIOS) and a Literature review Johanna Pacheco A., MD,1 Olga Morales M., MD,2 Alejandra Wilches L., MD.3 1 Pediatrician from the University of Antioquia, Abstract Master’s Degree Student in Pediatric Clinical Nutrition at INTA in Chile Patients with cystic fibrosis (CF) have greater than normal mucosal viscosity and prolonged intestinal transit 2 Pediatric Pulmonologist in the Faculty of Medicine at times which can result in meconium ileus, distal intestinal obstruction syndrome (DIOS) and constipation of the University of Antioquia in Medellin, Colombia varying severity. 3 Pediatric Gastroenterologist at San Vicente Fundación Hospital Universitario in Medellín, The cystic fibrosis working group of the European Society of Gastroenterology, Hepatology and Pediatric Colombia Nutrition produced a consensus in 2010 that defined distal intestinal obstruction syndrome (DIOS) as acute intestinal obstruction which may be complete or incomplete. Fully developed DIOS is defined as bilious vo- The cases reported here were treated at San Vicente Fundación Hospital Universitario in Medellín, miting and/or sufficient amounts of fluid and air in the small intestine to be observed in an abdominal X-ray, a Colombia. fecal mass in the ileocecal area, pain and/or bloating. Incomplete DIOS is defined as abdominal pain and/or No financial resources or other resources from any bloating and fecal mass in the ileocecal area, but without the other signs of complete obstruction. Colombian or international entity were received for this research. The incidence of this condition in cystic fibrosis patients varies. Depending on the definition used, the preva- lence of DIOS has been measured between 7% and 8% in children with cystic fibrosis, but has been reported ........................................ -
Gastrointestinal Motility Physiology
GASTROINTESTINAL MOTILITY PHYSIOLOGY JAYA PUNATI, MD DIRECTOR, PEDIATRIC GASTROINTESTINAL, NEUROMUSCULAR AND MOTILITY DISORDERS PROGRAM DIVISION OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, CHILDREN’S HOSPITAL LOS ANGELES VRINDA BHARDWAJ, MD DIVISION OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION CHILDREN’S HOSPITAL LOS ANGELES EDITED BY: CHRISTINE WAASDORP HURTADO, MD REVIEWED BY: JOSEPH CROFFIE, MD, MPH NASPGHAN PHYSIOLOGY EDUCATION SERIES SERIES EDITORS: CHRISTINE WAASDORP HURTADO, MD, MSCS, FAAP [email protected] DANIEL KAMIN, MD [email protected] CASE STUDY 1 • 14 year old female • With no significant past medical history • Presents with persistent vomiting and 20 lbs weight loss x 3 months • Initially emesis was intermittent, occurred before bedtime or soon there after, 2-3 hrs after a meal • Now occurring immediately or up to 30 minutes after a meal • Emesis consists of undigested food and is nonbloody and nonbilious • Associated with heartburn and chest discomfort 3 CASE STUDY 1 • Initial screening blood work was unremarkable • A trial of acid blockade was started with improvement in heartburn only • Antiemetic therapy with ondansetron showed no improvement • Upper endoscopy on acid blockade was normal 4 CASE STUDY 1 Differential for functional/motility disorders: • Esophageal disorders: – Achalasia – Gastroesophageal Reflux – Other esophageal dysmotility disorders • Gastric disorders: – Gastroparesis – Rumination syndrome – Gastric outlet obstruction : pyloric stricture, pyloric stenosis • -
Constipation.Pdf
Constipation National Digestive Diseases Information Clearinghouse What is constipation? The large intestine absorbs water and any remaining nutrients from partially digested Constipation is a condition in which a person food passed from the small intestine. The has fewer than three bowel movements a large intestine then changes waste from week or has bowel movements with stools liquid to a solid matter called stool. Stool that are hard, dry, and small, making them passes from the colon to the rectum. The painful or difficult to pass. People may feel rectum is located between the last part of bloated or have pain in their abdomen—the the colon—called the sigmoid colon—and area between the chest and hips. Some the anus. The rectum stores stool prior people think they are constipated if they do to a bowel movement. During a bowel not have a bowel movement every day. Bowel movement, stool moves from the rectum to movements may occur three times a day or the anus, the opening through which stool three times a week, depending on the person. leaves the body. Most people get constipated at some point in their lives. Constipation can be acute, which means sudden and lasting a short time, or chronic, which means lasting a long time, even years. Most constipation is acute and not dangerous. Understanding the causes, prevention, and treatment of constipation can help many people take steps to find relief. What is the gastrointestinal (GI) tract? Colon The GI tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus. -
Gastrointestinal Motility
Gastrointestinal Motility H. J. Ehrlein and M.Schemann 1. Motility of the stomach Anatomic regions of the stomach are the fundus, corpus (body), antrum and pylorus. The functional regions of the stomach do not correspond to the anatomic regions. Functionally, the stomach can be divided into the gastric reservoir and the gastric pump (Fig. 1). The gastric reservoir consists of the fundus and corpus. The gastric pump is represented by the area at which peristaltic waves occur: it includes the distal part of the corpus and the antrum. Due to different properties of the smooth muscle cells the gastric reservoir is characterised by tonic activity and the gastric pump by phasic activity. AB Gastric reservoir Fundus tonic contractions Pylorus Corpus Antrum Gastric pump phasic contractions Figure 1 . The stomach can be divided into three anatomic (A) and two functional regions (B) 1.1 Function of the gastric reservoir At the beginning of the 20 th century it was already observed that with increasing volume of the stomach the internal pressure of the stomach increases only slightly. In dogs, for instance, the increase in pressure is only 1.2 cm of water/100 ml volume. The small increase in gastric pressure indicates that the stomach does not behave like an elastic balloon but that it relaxes as it fills. Three kinds of gastric relaxation can be differentiated: a receptive, an adaptive and a feedback-relaxation of the gastric reservoir. The receptive relaxation consists of a brief relaxation during chewing and swallowing. The stimulation of mechano-receptors in the mouth and pharynx induces vago-vagal reflexes which cause a relaxation of the gastric reservoir (Fig. -
Report of an Unusual Case with Severe Fecal Impaction Responding to Medication Therapy
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by PubMed Central J Neurogastroenterol Motil, Vol. 16 No. 2 April, 2010 DOI: 10.5056/jnm.2010.16.2.199 Case Report JNM Journal of Neurogastroenterology and Motility Report of an Unusual Case With Severe Fecal Impaction Responding to Medication Therapy Wei Zhao, MD and Meiyun Ke, MD* Department of Gastroenterology, PUMC Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China ㅋ Fecal impaction is a disorder characterized by a large mass of compacted feces in the rectum and/or colon, which cannot be evacuated. For mild and moderate fecal impaction, recommended treatments include stool softeners, oral mineral and olive oil, and edema; for severe fecal impaction, manual removal is needed and sometimes laparotomy may be indicated if medical therapies are not effective. Here we report a case with severe fecal impaction who did not defecate for 75 days. We treated this patient with vegetable oil, Chinese traditional medicine and enema in sequence. After 12 days of therapy, she evacuated hard fecal masses, and the symptoms were relieved. (J Neurogastroenterol Motil 2010;16:199-202) Key Words Fecal impaction, Intestinal obstruction, Therapy severe fecal impaction with no bowel movements for 75 days, in whom vegetable oil, Chinese traditional medicine and enema ad- Introduction ministered in sequence successively relieved the symptoms. Fecal impaction is a disorder characterized by a large mass of compacted feces in the rectum and/or colon, which cannot be evacuated. It is reported fecal impaction can occur in childhood, Case Report old age and some patients with spinal cord injury.1 With less sys- A 55-year-old Chinese woman visited gastrointestinal clinic temic review, the true incidence is not certain.