DOCSLIB.ORG

WO 2015/076840 Al 28 May 2015 (28.05.2015) P O P C T

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
WO 2015/076840 Al 28 May 2015 (28.05.2015) P O P C T (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2015/076840 Al 28 May 2015 (28.05.2015) P O P C T (51) International Patent Classification: (74) Agent: OREMLAND, Lawrence R.; Lawrence R. Orem- A61K 33/34 (2006.01) land, P.C., 5055 E. Broadway Blvd., suite C-214, Tucson, AZ 8571 1 (US). (21) International Application Number: PCT/US20 13/07 1669 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 25 November 2013 (25.1 1.2013) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (26) Publication Language: English KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, (63) Related by continuation (CON) or continuation-in-part MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (CIP) to earlier applications: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, US 13/480,367 (CIP) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, Filed on 24 May 2012 (24.05.2012) TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, US 61/51 9,523 (CIP) zw. Filed on 24 May 201 1 (24.05.201 1) (84) Designated States (unless otherwise indicated, for every US 61/582,322 (CIP) kind of regional protection available): ARIPO (BW, GH, Filed on 3 1 December 201 1 (3 1.12.201 1) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (71) Applicant: AGIENIC, INC. [US/US]; 4541 E. Fort Low UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, ell Road, Tucson, AZ 85712 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, ΓΓ, LT, LU, LV, (72) Inventors: AGRAWAL, Anoop; 441 1 N. Camino Sumo, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Tucson, AZ 85718 (US). KRASNOW, Nicholas, R.; 2930 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, N. Tucson Boulevard, Tucson, AZ 85716 (US). CRONIN, KM, ML, MR, NE, SN, TD, TG). John P.; 4545 North Osage Drive, Tucson, AZ 85718 (US). ADAMS, Lori L.; 10950 N. La Canada Drive, Apt Published: 26-202, Tucson, AZ 85737 (US). AKARSU, Murat; — with international search report (Art. 21(3)) Meltem Mah. Ant-belde Sitesi 1., Blok No: 8 07030, Anta — with information concerning one or more priority claims lya (TR). REESER, Ryan, J.; 8001 East Ocotillo Drive, considered void (Rule 26bis.2(d)) Tucson, AZ 85750 (US). LOPEZ-TONAZZI, Juan Car¬ los; 6400 Montrose Dr, Tucson, AZ 85741 (US). UHL- MANN, Donald R.; 5309 East Mission Hills Drive, Tuc son, AZ 85718 (US). © (54) Title: ANTIMICROBIAL COMPOSITIONS FOR USE IN PRODUCTS FOR PETROLEUM EXTRACTION, PERSONAL 0 0 CARE, WOUND CARE AND OTHER APPLICATIONS © (57) Abstract: Compositions having antimicrobial activity contain surface functionalized particles comprising an inorganic copper salt which has low water solubility. These types of inorganic salts may also be introduced in porous particles to yield antimicrobial compositions. The compositions may optionally comprise additional antimicrobial agents, salts with high water solubility, organic o acids, salts of organic acids and their esters. The compositions may be added to various fluids used in the petroleum extraction in dustry, or used as coatings on components used in this industry. These antimicrobial, materials may be used for reducing both anaer obic and aerobic bacteria and are also useful for reducing corrosion of ferrous components caused by anaerobic bacteria. Although such compositions may be used for any antimicrobial application, and some of the other important uses of these compositions are in wound care, personal care and waste processing,. ANTIMICROBIAL COMPOSITIONS FOR USE IN PRODUCTS FOR PETROLEUM EXTRACTION, PERSONAL CARE, WOUND CARE AND OTHER APPLICATIONS CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of co-pending U.S. Application Serial No. 13/480,367, filed May 24, 2012, which application in turn claims priority to U.S. Provisional Patent Application Ser. No. 61/519,523, filed 5/24/201 1, US Provisional Patent Application ser. No. 61/582,322 filed 12/31/201 1; a continuation-in-part of US Application Serial number 13/685,379 filed on 11/26/2012 which is a continuation in part of U.S. Application Serial No. 13/480,367; and is related to and claims priority from US Provisional Patent Application serial numbers 61800122 filed on 3/15/2013; 61/820,561 filed on May 7, 2013, and 61/881,318 filed on Sept 23, 2013. The contents of all of the foregoing applications are incorporated herein by reference in their entirety. FIELD OF THE INVENTION The invention relates to antimicrobial compositions comprising surface functionalized particles of low water solubility inorganic copper salts, or such copper salts or silver salts infused into porous particles, their preparation, combinations of these copper-based particles with other antimicrobial materials, application of the compositions and methods of preparation. BACKGROUND OF THE INVENTION The antimicrobial effect of various metals and their salts has been known for centuries. Its germicidal effects increased its value in utensils and as jewelry. The exact process of silver's germicidal effect is still not entirely understood, although theories exist. One of these is the "oligodynamic effect," which qualitatively explains the effect on some microorganisms, but cannot explain antiviral effects. Silver is widely used in topical gels and impregnated into bandages because of its wide-spectrum antimicrobial activity. The oligodynamic effect is demonstrated by other metals, specifically gold, silver, copper, zinc, and bismuth. Copper is one such metal. Copper has long been used as a biostatic surface to line the bottoms of ships to protect against barnacles and mussels. It was originally used in pure form, but has since been superseded by brass and other alloys due to their lower cost and higher durability. Bacteria will not grow on a copper surface because it is biostatic. Copper alloys have become important netting materials in the aquaculture industry for the fact that they are antimicrobial and prevent biofouling and have strong structural and corrosion-resistant properties in marine environments. Organic compounds of copper are useful for preventing fouling of ships' hulls. Copper alloy touch surfaces have recently been investigated as antimicrobial surfaces in hospitals for decreasing transmission of nosocomial infections. Numerous scientific investigations have focused on the role of the metal form of copper, and have concluded that multiple mechanisms may be possible for copper's antimicrobial effect, including increased production of reactive oxidation species such as singlet oxygen and hydroxide radicals, covalent binding of copper metal to reactive sites in enzymes and co-factors, interference with lipid bilayer transport proteins, and interaction of copper ions with moieties of microorganisms analogous to what have been proposed for silver ions. SUMMARY OF THE INVENTION The inventors associated with this patent have made the surprising discovery that antimicrobial compositions comprising particles comprising certain low water solubility copper salts have much greater efficacy against a broad range of aerobic and anaerobic microbes, including bacteria, viruses, molds and fungi, than similar silver-based antimicrobial particles. In particular, it has been discovered that particles of copper salts including the copper halide and specifically copper iodide ("Cul"), when formulated in accordance with the teachings herein, is surprisingly effective as a broad-spectrum, fast- acting antimicrobial agent. The particles of these salts are surface functionalized. In a further embodiment, high water solubility salts may be added to the compositions comprising the inventive particles. In a particularly preferred embodiment, the high water solubility salts comprise at least one halide salt with a room temperature water solubility of greater than lg/liter. In yet another embodiment, organic acids, salts of organic acids, and esters of organic acids may be used as functionalization agents for the particles or as additives to the antimicrobial compositions. In yet another embodiment, the antimicrobial compositions of this invention may be used to manufacture solid or liquid products with antimicrobial properties. In a further embodiment, the functionlization agents preferably have a molecular weight of at least 60. In yet another embodiment, the antimicrobial compositions are used in the petroleum extraction industry, personal care products and wound management. Another embodiment of the present invention is the use of the above antimicrobial compositions is to kill anaerobic as well as aerobic bacteria. In yet another surprising discovery, the preparation of the inventive particles using wet grinding processes enhances their economic viability and provides several other benefits. Such processes may be used to produce functionalized particles of other low water solubility salts and compounds such as silver halides. In a further embodiment, one may deposit the copper salts of low water solubility or silver halides in porous particles, wherein such porous particles are used as additives to various carriers (liquids or solids) or products to impart antimicrobial properties to these. These and other features of the present invention will become apparent from the following detailed description and the accompanying drawings BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a plot of Optical Density (OD, Y-axis) against P. aeruginosa growth and/or inhibition by copper iodide particles and Ag-Cul mixed metal halides, and a control.
Load more

Recommended publications
  • Germanium Tetraiodide
    GEG5800 - GERMANIUM TETRAIODIDE GERMANIUM TETRAIODIDE Safety Data Sheet GEG5800 Date of issue: 08/10/2015 Version: 1.0 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Substance Physical state : Solid Substance name : GERMANIUM TETRAIODIDE Product code : GEG5800 Formula : GeI4 Synonyms : CHLOROTRIPHENYLGERMANE; TRIPHENYLGERMANIUM CHLORIDE Chemical family : GERMANIUM IODIDE 1.2. Relevant identified uses of the substance or mixture and uses advised against Use of the substance/mixture : Chemical intermediate For research and industrial use only 1.3. Details of the supplier of the safety data sheet GELEST, INC. 11 East Steel Road Morrisville, PA 19067 USA T 215-547-1015 - F 215-547-2484 - (M-F): 8:00 AM - 5:30 PM EST [email protected] - www.gelest.com 1.4. Emergency telephone number Emergency number : CHEMTREC: 1-800-424-9300 (USA); +1 703-527-3887 (International) SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification (GHS-US) Skin Corr. 1B H314 Eye Dam. 1 H318 Full text of H-phrases: see section 16 2.2. Label elements GHS-US labeling Hazard pictograms (GHS-US) : GHS05 Signal word (GHS-US) : Danger Hazard statements (GHS-US) : H314 - Causes severe skin burns and eye damage H318 - Causes serious eye damage Precautionary statements (GHS-US) : P280 - Wear protective gloves/protective clothing/eye protection/face protection P260 - Do not breathe dust P264 - Wash hands thoroughly after handling P301+P330+P331 - If swallowed: rinse mouth. Do NOT induce vomiting P303+P361+P353 - If on skin (or hair): take off immediately all contaminated clothing.
    [Show full text]
  • United States Patent (19) 11 Patent Number: 6,127,310 Brown Et Al
    USOO612731 OA United States Patent (19) 11 Patent Number: 6,127,310 Brown et al. (45) Date of Patent: *Oct. 3, 2000 54) PALLADIUM CONTAINING 5,489,565 2/1996 Cheung et al. ......................... 502/325 HYDROGENATION CATALYSTS 5,498,806 3/1996 Ichikawa et al. ....................... 570/156 5,527,946 6/1996 Flick et al. .............................. 558/459 75 Inventors: Scott H. Brown; Tin-Tack Peter 55. 13.1. E. th - - - - - - - - - - - - - - - - - - - - - - - - - S. 2- Y - 2 OlSOl C al. ......................... Cheung, both of Bartlesville, Okla. 5,587,348 12/1996 Brown et al. ........................... 502/230 O O 5,648,576 7/1997 N Than et al. ............. 585/260 (73) Assignee: Phillips Petroleum Company, 5,698,752 12/1997 E. an et a- - - - - - - - - - - - - - - - - - 585/260 Bartlesville, Okla. 5,750,806 5/1998 Brocker et al. ... 568/909.5 5,866,734 2/1999 Flick et al. .............................. 585/260 * Notice: This patent issued on a continued pros- 5,866,746 2/1999 Didillion et al. ....................... 585/661 ecution application filed under 37 CFR 1.53(d), and is subject to the twenty year FOREIGN PATENT DOCUMENTS patent term provisions of 35 U.S.C. O398466 11/1990 European Pat. Off. 154(a)(2). 2720946 12/1995 France. 1018661 1/1966 United Kingdom. 21 Appl. No.: 08/808,047 OTHER PUBLICATIONS 22 Filed: Feb. 27, 1997 Engelhard De Meern “Hydrogenation and/or dehydrogena (51) Int. Cl." ...................................................... B01J 23/44 tion catalysts-contg. hydrogenation component and metal 52 U.S. Cl. .......................... s02.339: 502,344, 502/347. Oxide as separate particles"-abstract of EP 398446, Nov. 502/348; 502/325, 502/326; 502/327: 502/328; 1990.
    [Show full text]
  • Standard X-Ray Diffraction Powder Patterns
    E^l Admin. NBS MONOGRAPH 25—SECTION 5 Refecii^M not to be ^ferlrom the library. Standard X-ray Diffraction Powder Patterns ^\ / U.S. DEPARTMENT OF COMMERCE S NATIONAL BUREAU OF STANDARDS THE NATIONAL BUREAU OF STANDARDS The National Bureau of Standards^ provides measurement and technical information services essential to the efficiency and effectiveness of the work of the Nation's scientists and engineers. The Bureau serves also as a focal point in the Federal Government for assuring maximum application of the physical and engineering sciences to the advancement of technology in industry and commerce. To accomplish this mission, the Bureau is organized into three institutes covering broad program areas of research and services: THE INSTITUTE FOR BASIC STANDARDS . provides the central basis within the United States for a complete and consistent system of physical measurements, coordinates that system with the measurement systems of other nations, and furnishes essential services leading to accurate and uniform physical measurements throughout the Nation's scientific community, industry, and commerce. This Institute comprises a series of divisions, each serving a classical subject matter area: —Applied Mathematics—Electricity—Metrology—Mechanics—Heat—Atomic Physics—Physical Chemistry—Radiation Physics— -Laboratory Astrophysics^—Radio Standards Laboratory,^ which includes Radio Standards Physics and Radio Standards Engineering—Office of Standard Refer- ence Data. THE INSTITUTE FOR MATERIALS RESEARCH . conducts materials research and provides associated materials services including mainly reference materials and data on the properties of ma- terials. Beyond its direct interest to the Nation's scientists and engineers, this Institute yields services which are essential to the advancement of technology in industry and commerce.
    [Show full text]
  • Germanium Diiodide
    GEG5200 - GERMANIUM DIIODIDE GERMANIUM DIIODIDE Safety Data Sheet GEG5200 Date of issue: 01/05/2015 Version: 1.0 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Substance Physical state : Solid Substance name : GERMANIUM DIIODIDE Product code : GEG5200 Formula : I2Ge Synonyms : DIIODOGERMANE; GERMANIUM II IODIDE Chemical family : GERMANIUM IODIDE 1.2. Relevant identified uses of the substance or mixture and uses advised against Use of the substance/mixture : Chemical intermediate For research and industrial use only 1.3. Details of the supplier of the safety data sheet GELEST, INC. 11 East Steel Road Morrisville, PA 19067 USA T 215-547-1015 - F 215-547-2484 - (M-F): 8:00 AM - 5:30 PM EST [email protected] - www.gelest.com 1.4. Emergency telephone number Emergency number : CHEMTREC: 1-800-424-9300 (USA); +1 703-527-3887 (International) SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification (GHS-US) Skin Corr. 1B H314 Eye Dam. 1 H318 Full text of H-phrases: see section 16 2.2. Label elements GHS-US labeling Hazard pictograms (GHS-US) : GHS05 Signal word (GHS-US) : Danger Hazard statements (GHS-US) : H314 - Causes severe skin burns and eye damage H318 - Causes serious eye damage Precautionary statements (GHS-US) : P280 - Wear protective gloves/protective clothing/eye protection/face protection P260 - Do not breathe dust P264 - Wash hands thoroughly after handling P301+P330+P331 - If swallowed: rinse mouth. Do NOT induce vomiting P303+P361+P353 - If on skin (or hair): Take off immediately all contaminated clothing.
    [Show full text]
  • Standard X-Ray Diffraction Powder Patterns
    NBS MONOGRAPH 25—SECTION 4 Standard X-ray Diffraction Powder Patterns U.S. DEPARTMENT OF COMMERCE NATIONAL BUREAU OF STANDARDS THE NATIONAL BUREAU OF STANDARDS The National Bureau of Standards is a principal focal point in the Federal Government for assuring maximum application of the physical and engineering sciences to the advancement of technology in industry and commerce. Its responsibilities include development and mainte- nance of the national standards of measurement, and the provisions of means for making measurements consistent with those standards; determination of physical constants and properties of materials; development of methods for testing materials, mechanisms, and structures, and making such tests as may be necessary, particularly for government agencies; cooperation in the establishment of standard practices for incorporation in codes and specifi- cations advisory service to government agencies on scientific and technical problems ; invention ; and development of devices to serve special needs of the Government; assistance to industry, business, and consumers m the development and acceptance of commercial standards and simplified trade practice recommendations; administration of programs in cooperation with United States business groups and standards organizations for the development of international standards of practice; and maintenance of a clearinghouse for the collection and dissemination of scientific, technical, and engineering information. The scope of the Bureau's activities is suggested in the following listing of its three Institutes and their organizatonal units. Institute for Basic Standards. Applied Mathematics. Electricity. Metrology. Mechanics. Heat. Atomic Physics. Physical Chemistry. Laboratory Astrophysics.* Radiation Phys- ics. Radio Standards Laboratory:* Radio Standards Physics; Radio Standards Engineering. Office of Standard Reference Data. Institute for Materials Research.
    [Show full text]
  • Standard X-Ray Diffraction Powder Patterns
    7 NATL INST OF STANDARDS & TECH R.I.C. Nes AlllOD Ififib^fi PUBLICATIONS 100988698 ST5°5rv'25-17;1980 C.1 NBS-PUB-C 19 cr»T OF NBS MONOGRAPH 25-SECTION 1 V) J U.S. DEPARTMENT OF COMMERCE / National Bureau of Standards Standard X-ray Diffraction Powder Patterns . NATIONAL BUREAU OF STANDARDS The National Bureau of Standards' was established by an act ot Congress on March 3, 1901 The Bureau's overall goal is to strengthen and advance the Nation's science and technology and facilitate their effective application for public benefit. To this end, the Bureau conducts research and provides: (1) a basis for the Nation's physical measurement system, (2) scientific and technological services for industry and government, (3) a technical basis for equity in trade, and (4) technical services to promote public safety. The Bureau's technical work is per- formed by the National Measurement Laboratory, the National Engineering Laboratory, and the Institute for Computer Sciences and Technology. THE NATIONAL MEASUREMENT LABORATORY provides the national system of physical and chemical and materials measurement; coordinates the system with measurement systems of other nations and furnishes essential services leading to accurate and uniform physical and chemical measurement throughout the Nation's scientific community, industry, and commerce; conducts materials research leading to improved methods ol measurement, standards, and data on the properties of materials needed by industry, commerce, educational institutions, and Government; provides advisory and research services to other Government agencies; develops, produces, and distributes Standard Reference Materials; and provides calibration services. The Laboratory consists of the following centers: Absolute Physical Quantities- — Radiation Research — Thermodynamics and Molecular Science — Analytical Chemistry — Materials Science.
    [Show full text]
  • Standard X-Ray Diffraction Powder Patterns
    3. 41 NBS MONOGRAPH 25—SECTION 4 Standard X-ray Diffraction Powder Patterns U.S. DEPARTMENT OF COMMERCE NATIONAL BUREAU OF STANDARDS UNIVERSITY or ARIZONA LIBFU Documents Collet OCT 4 1966 THE NATIONAL BUREAU OF STANDARDS The National Bureau of Standards is a principal focal point in the Federal Government for assuring maximum application of the physical and engineering sciences to the advancement of technology in industry and commerce. Its responsibilities include development and mainte nance of the national standards of measurement, and the provisions of means for making measurements consistent with those standards; determination of physical constants and properties of materials; development of methods for testing materials, mechanisms, and structures, and making such tests as may be necessary, particularly for government agencies; cooperation in the establishment of standard practices for incorporation in codes and specifi cations; advisory service to government agencies on scientific and technical problems; invention and development of devices to serve special needs of the Government; assistance to industry, business, and consumers in the development and acceptance of commercial standards and simplified trade practice recommendations; administration of programs in cooperation with United States business groups and standards organizations for the development of international standards of practice; and maintenance of a clearinghouse for the collection and dissemination of scientific, technical, and engineering information. The scope of the Bureau©s activities is suggested in the following listing of its three Institutes and their organizatonal units. Institute for Basic Standards. Applied Mathematics. Electricity. Metrology. Mechanics. Heat. Atomic Physics. Physical Chemistry. Laboratory Astrophysics.* Radiation Phys ics. Radio Standards Laboratory:* Radio Standards Physics; Radio Standards Engineering.
    [Show full text]
  • Standard X-Ray Diffraction Powder Patterns
    NBS MONOGRAPH 25 SECTION 6 Standard X-ray Diffraction Powder Patterns UNIVERSITY OF ARIZONA LIBRARY Documents Collection AUG 19 1888 THE NATIONAL BUREAU OF STANDARDS The National Bureau of Standards1 provides measurement and technical information services essential to the efficiency and effectiveness of the work of the Nation's scientists and engineers. The Bureau serves also as a focal point in the Federal Government for assuring maximum application of the physical and engineering sciences to the advancement of technology in industry and commerce. To accomplish this mission, the Bureau is organized into three institutes covering broad program areas of research and services: THE INSTITUTE FOR BASIC STANDARDS . provides the central basis within the United States for a complete and consistent system of physical measurements, coordinates that system with the measurement systems of other nations, and furnishes essential services leading to accurate and uniform physical measurements throughout the Nation's scientific community, industry, and commerce. This Institute comprises a series of divisions, each serving a classical subject matter area: —Applied Mathematics—Electricity—Metrology—Mechanics—Heat—Atomic Physics—Physical Chemistry—Radiation Physics—-Laboratory Astrophysics2—Radio Standards Laboratory,2 which includes Radio Standards Physics and Radio Standards Engineering—Office of Standard Refer ence Data. THE INSTITUTE FOR MATERIALS RESEARCH . conducts materials research and provides associated materials services including mainly reference materials and data on the properties of ma terials. Beyond its direct interest to the Nation's scientists and engineers, this Institute yields services which are essential to the advancement of technology in industry and commerce. This Institute is or ganized primarily by technical fields: —Analytical Chemistry—Metallurgy—Reactor Radiations—Polymers—Inorganic Materials—Cry ogenics2—Office of Standard Reference Materials.
    [Show full text]
  • Standard X-Ray Diffraction Powder Patterns NATIONAL BUREAU of STANDARDS
    NATL INST OF STANDARDS & TECH R.I.C. NBS AlllDO =Jfifib30 PUBLICATIONS 100988630 Ku5°5lT25-13;1976 C.1 NBS-PUB-C 19 4^ ^ ^ 4» NBS MONOGRAPH 25 - SECTION 13 VI U.S. DEPARTMENT OF COMR/IERCE / National Bureau of Standards Standard X-ray Diffraction Powder Patterns NATIONAL BUREAU OF STANDARDS The National Bureau of Standards' was established by an act of Congress March 3, 1901. The Bureau's overall goal is to strengthen and advance the Nation's science and technology and facilitate their effective application for public benefit. To this end, the Bureau conducts research and provides: (1) a basis for the Nation's physical measurement system, (2) scientific and technological services for industry and government, (3) a technical basis for equity in trade, and (4) technical services to promote public safety. The Bureau consists of the Institute for Basic Standards, the Institute for Materials Research, the Institute for Applied Technology, the Institute for Computer Sciences and Technology, and the Office for Information Programs. THE INSTITUTE FOR BASIC STANDARDS provides the central basis within the United States of a complete and consistent system of physical measurement; coordinates that system with measurement systems of other nations; and furnishes essential services leading to accurate and uniform physical measurements throughout the Nation's scientific community, industry, and commerce. The Institute consists of the Office of Measurement Services, the Office of Radiation Measurement and the following Center and divisions: Applied Mathematics
    [Show full text]
  • Standard X-Ray Diffraction Powder Patterns
    NBS MONOGRAPH 25—SECTION 6 Standard X-ray Diffraction Powder Patterns U.S. DEPARTMENT OF COMMERCE NATIONAL BUREAU OF STANDARDS ( I THE NATIONAL BUREAU OF STANDARDS The National Bureau of Standards^ provides measurement and technical information services essential to the efficiency and effectiveness of the work of the Nation's scientists and engineers. The Bureau serves also as a focal point in the Federal Government for assuring maximum application of the physical and engineering sciences to the advancement of technology in industry and commerce. To accomplish this mission, the Bureau is organized into three institutes covering broad program areas of research and services: THE INSTITUTE FOR BASIC STANDARDS . provides the central basis within the United States for a complete and consistent system of physical measurements, coordinates that system with the measurement systems of other nations, and furnishes essential services leading to accurate and uniform physical measurements throughout the Nation's scientific community, industry, and commerce. This Institute comprises a series of divisions, each serving a classical subject matter area: —Applied Mathematics—Electricity—Metrology—Mechanics—Heat—Atomic Physics—Physical Chemistry—Radiation Physics— -Laboratory Astrophysics^—Radio Standards Laboratory,^ which includes Radio Standards Physics and Radio Standards Engineering—Office of Standard Refer- ence Data. THE INSTITUTE FOR MATERIALS RESEARCH . conducts materials research and provides associated materials services including mainly reference materials and data on the properties of ma- terials. Beyond its direct interest to the Nation's scientists and engineers, this Institute yields services which are essential to the advancement of technology in industry and commerce. This Institute is or- ganized primarily by technical fields: —Analytical Chemistry—Metallurgy—Reactor Radiations—Polymers—Inorganic Materials—Cry- ogenics^—Office of Standard Reference Materials.
    [Show full text]
  • Standard X-Ray Diffraction Powder Patterns
    E^l Admin. NBS MONOGRAPH 25—SECTION 5 Refecii^M not to be ^ferlrom the library. Standard X-ray Diffraction Powder Patterns ^\ / U.S. DEPARTMENT OF COMMERCE S NATIONAL BUREAU OF STANDARDS THE NATIONAL BUREAU OF STANDARDS The National Bureau of Standards^ provides measurement and technical information services essential to the efficiency and effectiveness of the work of the Nation's scientists and engineers. The Bureau serves also as a focal point in the Federal Government for assuring maximum application of the physical and engineering sciences to the advancement of technology in industry and commerce. To accomplish this mission, the Bureau is organized into three institutes covering broad program areas of research and services: THE INSTITUTE FOR BASIC STANDARDS . provides the central basis within the United States for a complete and consistent system of physical measurements, coordinates that system with the measurement systems of other nations, and furnishes essential services leading to accurate and uniform physical measurements throughout the Nation's scientific community, industry, and commerce. This Institute comprises a series of divisions, each serving a classical subject matter area: —Applied Mathematics—Electricity—Metrology—Mechanics—Heat—Atomic Physics—Physical Chemistry—Radiation Physics— -Laboratory Astrophysics^—Radio Standards Laboratory,^ which includes Radio Standards Physics and Radio Standards Engineering—Office of Standard Refer- ence Data. THE INSTITUTE FOR MATERIALS RESEARCH . conducts materials research and provides associated materials services including mainly reference materials and data on the properties of ma- terials. Beyond its direct interest to the Nation's scientists and engineers, this Institute yields services which are essential to the advancement of technology in industry and commerce.
    [Show full text]