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ROYAL ACADEMY OF MEDICINE IN IRELAND IRISH JOURNAL OF MEDICAL SCIENCE Irish Endocrine Society 40th Annual Meeting 14th and 15th October 2016 Stormont Hotel, Belfast Local Organiser: Doctor Hamish Courtney, REVISEDRoyal Victoria Hospital, PROOF Belfast Irish Journal of Medical Science Volume XXX Supplement X DOI 10.1007/s11845-016-1482-y 123 123 Journal : Large 11845 Dispatch : 17-8-2016 Pages : 57 Article No. : 1482 h LE h TYPESET MS Code : 1482 h44CP h DISK Ir J Med Sci Disclosure statement This supplement is paid for by the Irish Endocrine Society. However the meeting costs are supported by the following commercial sponsors: Abbott Amgen Astra Zeneca Besins Healthcare BMS Boehringer Ingleheim Consilient Ipsen Janssen-Cilag Kyowa Kirin Lilly Menarini Merck Serono MSD Novartis Novo Nordisk Pfizer Sanofi REVISED PROOF 123 Journal : Large 11845 Dispatch : 17-8-2016 Pages : 57 Article No. : 1482 h LE h TYPESET MS Code : 1482 h44CP h DISK Ir J Med Sci Novo Lecture Nordisk Lecture 1976 D.K. O’Donovan 1977 S. Bloom 1978 J.H.S. Robertson 1979 A.G. Cudworth 1980 D.A.D. Montgomery 1981 Peter Watkins 1982 G. Joplin 1983 D.R. London 1984 A.X. Bertagna 1985 Malcolm Nattrass Laurence Kennedy 1986 Brian Frier JB Ferriss 1987 Maurice Scanlon TJ McKenna 1988 D.A. Heath AB Atkinson 1989 J. Ward GH Tomkin 1990 R. Volpe KD Buchanan 1991 Michael Besser PPA Smyth 1992 R.V. Ragontte DH Hadden 1993 Bruce Weintraub David Powell 1994 Oscar Croffard Patrick Bell 1995 Robert Lindsay Brian Sheridan 1996 C.R.W. Edwards Rosemary Freaney 1997 Stephanie Amiel David McCance 1998 Robert Turner Randle Hayes 1999 Ian Hay Sean K Cunningham 2000 Stephen O’Rahilly Michael Cullen 2001 Andre Lacroix Daphne Owens 2002 J. Tuomilehto Chris Thompson 2003 Tony Weetman John Nolan 2004 R.V. Thakker RGR Firth 2005 P.M. Stewart FMP O’Harte 2006 Kevin Docherty CH Walsh 2007 Lynnette Nieman Timothy O’Brien 2008 Ken Ho Donal O’Shea 2009 Daniel J. Drucker Steven Hunter 2010 Joseph G. Verbalis James Gibney 2011 Thomas A. Buchanan Maria Byrne 2012 Beverly M.K. Biller Fidelma Dunne 2013 Mark McCarthy Diarmuid Smith 2014REVISED Karel Pacak PROOF Sean F Dinneen 2015 European Society of Endocrinology meeting, Dublin Lifetime Achievement Award 2012 David Hadden 2013 T Joseph McKenna 2014 Gerard Tomkin 123 Journal : Large 11845 Dispatch : 17-8-2016 Pages : 57 Article No. : 1482 h LE h TYPESET MS Code : 1482 h44CP h DISK Ir J Med Sci Friday 14th of October 2016 1 pm to 1.45 pm Poster Viewing Session 1.50 pm Welcome and Introduction Professor FPM O’Harte President, Irish Endocrine Society Friday Oral Presentations 2.00 pm OC1. Epidemiology of Gestational Diabetes Mellitus according to IADPSG/WHO 2013 criteria among Obese Pregnant Women in Europe Egan AM1, Vellinga A1, Desoye G2, van Poppel MNM3, Simmons D4, Dunne FP1 on behalf of the DALI Core Investigator Group. 1National University of Ireland, Galway, Ireland, 2Department of Obstetrics and Gynecology, Medizinische Universitaet Graz, Graz, Austria, 3Department of Public and Occupational Health, EMGO+-Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands and 4Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, England and Macarthur Clinical School, Western Sydney University, Sydney, Australia 2.15 pm OC2. Tumour necrosis factor related apoptosis inducing ligand (TRAIL) reduces oxidative stress in human aortic endothelial cells exposed to inflammatory stimuli Forde H,1,2 Harper E,2 Davenport C,1 Rochford KD,2 Cummins PM,2 Smith D1 1Department of Endocrinology, Beaumont Hospital, Beaumont, Dublin 9, 2Department of Endothelial Cell Biology, Dublin City University, Glasnevin, Dublin 9 2.30 pm OC3. Abnormal aldosterone/renin ratio is common in patients of African compared to European origin, is associated with hypokalaemia and left ventricular hypertrophy, but is rarely associated with abnormal adrenal imaging characteristics Ahmed KS1, Bogdanet D1, Heshe S2, Boran G3, Behan LA1, Sherlock M1, Gibney J1 1Departments of Endocrinology, Cardiology2 and Chemical Pathology3, The Adelaide and Meath Hospital, Incorporating the National Children’s Hospital, Tallaght, Dublin 24 2.45 pm OC4. What are the clinical consequences of changes induced in the hypothalamic-pituitary-thyroid axis following growth hormone replacement? Glynn N1, Kenny H2, Salim T3, Halsall DJ4, Boran G5, Cook P6, Smith D1, Tun T7, McDermott JH7, Tormey W8, Thompson CJ1, McAdam B3, McKenna MJ9, O’ Gorman DJ2, Agha A1 Departments of Endocrinology1, Cardiology3 and Chemical Pathology8, Beaumont Hospital, Dublin, Ireland. School of Health and Human Performance2, Dublin City University, Ireland. Department of Clinical Biochemistry4, Addenbrooke’s Hospital, Cambridge, UK. Department of Clinical Biochemistry5, Adelaide and Meath Hospital, Dublin, Ireland. Department of Chemical Pathology6, University Hospital Southampton, UK. Department of Endocrinology7, Connolly Memorial Hospital, Dublin, Ireland. Department of Endocrinology9, St Vincent’s University Hospital, Dublin, Ireland 3.00 pm OC5. Insight into the molecular mechanisms underlying enhanced gonadotropin hormone receptor activity in polycystic ovarian syndrome Owens L, Lerner A, Sposini S, Christopoulos G, Liyanage M, Islam R, Lavery S, Tsui V, Hardy K, Franks S, Hanyaloglu A Institute of Reproductive and Developmental Biology, Imperial College London 3.15 pm OC6. How frequently can we predict failure of fluid restriction in SIAD (syndrome of inappropriate antidiuresis)? Results of a prospective, multicenter audit Cuesta M, Garrahy A, Slattery D, Ortola´ A1, Tormey W2, Calle-Pascual AL1, Runkle I1, Thompson CJ Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Dublin, Ireland, 1Servicio de Endocrinologı´a y NutricioREVISED´n, Hospital Clı´nico San Carlos/Universidad PROOF Complutense de Madrid, Espan˜a, 2Department of Chemical Pathology. Beaumont Hospital/RCSI Medical School, Dublin, Ireland 3.30–4.25 pm Coffee and Poster Viewing Session 123 Journal : Large 11845 Dispatch : 17-8-2016 Pages : 57 Article No. : 1482 h LE h TYPESET MS Code : 1482 h44CP h DISK Ir J Med Sci 4.30 pm OC7. Characterisation of the biological activity and therapeutic effectiveness of bone-targeting forms of glucose-dependent insulinotropic polypeptide (GIP) Vyavahare S, Barrie JW, Hasib A, Flatt PR, Irwin N School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom 4.45 pm OC8. A polymorphism in the KRAS 30 UTR microRNA binding site: A case–control analysis assessing impact on differentiated thyroid cancer risk Owens PW1,2, McVeigh TP1,2,3, Miller N1, Guerin C4, Sebag F4, Quill D1,2, Bell M5, Lowery AJ6, Kerin MJ1,2 1Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland, Galway. 2Department of Surgery, Galway University Hospital, Galway. 3Department of Clinical Genetics, Our Lady’s Children’s Hospital Crumlin, Dublin. 4Department of Endocrine Surgery, Hoˆpital de la Timone, Marseilles, France, 5Department of Endocrinology, Galway University Hospital, Galway. 6University of Limerick, Graduate Entry Medical School, Limerick 5.00 pm Inaugural IES Hadden Lecture Controversies in Diabetes 2016: Where do we go from here? Professor David M Nathan MD Director MGH Diabetes Centre and Clinical Research Centre Professor of Medicine, Harvard Medical School Saturday 15th of October 2016 8.00–9.00 am IES Annual General Meeting Oral Presentations 9.15 am OC9. The synthetic analogue apelin-13 amide, improves acute glucose tolerance via activation of the APJ receptor in diet induced obese diabetic mice Parthsarathy V, Hogg C, Flatt PR, O’Harte FPM The Saad Centre for Pharmacy and Diabetes, School of Biomedical Sciences, Ulster University, Coleraine, N. Ireland 9.30 am OC10. Investigation into the impact of Glucagon like peptide-1 therapy on IL-1 beta production in obesity Mat A1, Tobin L1, O’Brien1 A, Hogan A1, O’Shea D2 1Education and Research Centre, St Vincent’s University Hospital, Dublin 4 2Dept of Endocrinology, St Vincent’s University Hospital, Dublin 4 9.45 am OC11. Changes in adipose tissue gene expression profile and fat mass are associated with deteriorating glucose tolerance Woods CP1, Crowley RK2, Gathercole LL3, Hughes B4, Gray J4, McCarthy T4, Crabtree N4, Stewart pm:5, Tomlinson JW3 Naas General Hospital, Co Kildare1, St Vincent’s University Hospital, Elm Park, Dublin 42, Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM), NIHR Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK3, School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism (CEDAM), University of Birmingham, UK4, Department of Endocrinology, University of Leeds, UK5 10.00 am OC12. Vertical sleeve gastrectomy attenuates diabetic kidney disease in a rat model of obesity and type 2 diabetes Nair M1, Elliott J1,2, Jackson S1, Corteville C3,4, Abegg K3,5, Boza C6, Lutz T3,5, le Roux CW1,7, Docherty NG1,7 1Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Ireland. 2Department of Surgery, Trinity Centre for Health Sciences, St. James’s Hospital, Dublin, Ireland. 3Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Switzerland 4Department of Surgery, University of Wurzburg, Wurzburg, Germany. 5Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland 6Bariatric Surgery, Clinica Las Condes, Santiago, Chile 7Gastrosurgical Laboratory, Sahlgrenska
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  • Purification and Sequence of Rat Oxyntomodulin (Enteroglucagon/Peptide/Intestine/Proglucagon/Radlolmmunoassay) NATHAN L

    Purification and Sequence of Rat Oxyntomodulin (Enteroglucagon/Peptide/Intestine/Proglucagon/Radlolmmunoassay) NATHAN L

    Proc. Nati. Acad. Sci. USA Vol. 91, pp. 9362-9366, September 1994 Biochemistry Purification and sequence of rat oxyntomodulin (enteroglucagon/peptide/intestine/proglucagon/radlolmmunoassay) NATHAN L. COLLIE*t, JOHN H. WALSHO, HELEN C. WONG*, JOHN E. SHIVELY§, MIKE T. DAVIS§, TERRY D. LEE§, AND JOSEPH R. REEVE, JR.t *Department of Physiology, School of Medicine, University of California, Los Angeles, CA 90024; *Center for Ulcer Research and Education, Gastroenteric Biology Center, Department of Medicine, Veterans Administration Wadsworth Center, School of Medicine, University of California, Los Angeles, CA 90073; and §Division of Immunology, Beckman Institute of City of Hope Research Institute, Duarte, CA 91010 Communicated by Jared M. Diamond, May 26, 1994 ABSTRACT Structural information about rat enteroglu- glucagon plus two glucagon-like sequences (GLP-1 and -2) cagon, intestinal peptides containing the pancreatic glucagon arranged in tandem. The present study concerns the enter- sequence, has been based previously on cDNA, immunologic, oglucagon portion of proglucagon (i.e., the N-terminal 69 and chromatographic data. Our interests in testing the phys- residues and its potential cleavage fragments). iological actions of synthetic enteroglucagon peptides in rats Our use of the term "enteroglucagon" refers to intestinal required that we identify precisely the forms present in vivo. peptides containing the pancreatic glucagon sequence. Fig. 1 From knowledge of the proglucagon gene sequence, we syn- shows two proposed enteroglucagon forms, proglucagon-(1- thesized an enteroglucagon C-terminal octapeptide common to 69) (glicentin) and proglucagon-(33-69) (OXN; see Fig. 1). both proposed enteroglucagon forms, glicentin and oxynto- The primary structures based on amino acid sequence data of modulin, but sharing no sequence overlap with glucagon.