Genome-Wide Association Analysis of Lifetime Cannabis Use (N=184,765) Identifies New Risk Loci
bioRxiv preprint doi: https://doi.org/10.1101/234294; this version posted January 8, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use Joëlle A. Pasman1*, Karin J.H. Verweij1*, Zachary Gerring2, Sven Stringer3, Sandra Sanchez-Roige4, Jorien L. Treur5, Abdel Abdellaoui6, Michel G. Nivard6, Bart M.L. Baselmans6, Jue-Sheng Ong2, Hill F. Ip6, Matthijs D. van der Zee6, Meike Bartels6, Felix R. Day7, Pierre Fontanillas8, Sarah L. Elson8, the 23andMe Research Team8, Harriet de Wit9, Lea K. Davis10, James MacKillop11, International Cannabis Consortium, Jaime L. Derringer12, Susan J.T. Branje13, Catharina A. Hartman14, Andrew C. Heath15, Pol A.C. van Lier16, Pamela A.F. Madden15, Reedik Mägi17, Wim Meeus13, Grant W. Montgomery18, A.J. Oldehinkel14, Zdenka Pausova19, Josep A. Ramos-Quiroga20-23, Tomas Paus24,25, Marta Ribases20-22, Jaakko Kaprio26, Marco P.M. Boks27, Jordana T. Bell28, Tim D. Spector28, Joel Gelernter29, Dorret I. Boomsma6, Nicholas G. Martin2, Stuart MacGregor2, John R.B. Perry7, Abraham A. Palmer4,30, Danielle Posthuma3, Marcus R. Munafò5,31, Nathan A. Gillespie2,32†, Eske M. Derks2†, & Jacqueline M. Vink1† *Shared first author †Shared last author 1. Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands 2. Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia 3. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands 4.
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