Quarterly Newsletter | Issue 3 July - September 2020 MedNews If you want to know more...

“Tomorrow’s IVF Laboratory”: A Peek into the Future

Another edition of the annual that automation promises consistency, high quality time-lapse images of embryos ESHRE Meeting has culminated, safety, reliability (without the need for developing in “real-time” without having and although it was done virtually, more extensive training for embryologists), to remove the embryos from the safety and with the intention to improve access of the incubation chamber for manual it was still a success. Esco Medical to care. Despite being automated, this microscopy. Time-lapse embryo monitoring managed to participate in the kind of technology will not eliminate the provides detailed morphokinetic data online exhibit and to some of us; need for an embryologist. However, one throughout embryo development, which is we were able to catch up with primary issue that could possibly hinder not available on routine spot microscopic its acceptance is the obvious cost or evaluation. This allows all important events some scientific sessions inside the affordability. to be observed, helping to identify healthy comfort of our own homes (and embryos with the highest probability of offices). Dr. Morbeck also noted that the innovation implantation, with the aim of achieving we have seen in IVF the past years have higher pregnancy rates. One particular session that tickled our had varying impacts, ranging from those interest is about “Tomorrow’s IVF processes that have become key game Other predictions Morbeck mentioned in Laboratory”. Each session have several changers in the field as they have improved his talk include the following: speakers who discussed specific topics. implantation rates (like ICSI, blastocyst 1. In vitro maturation (IVM) will become a Notable discussions I find really thought- culture, and agonist ovulation triggers) to tool for selected patients. IVM is an assisted provoking and remarkable as a product those concepts that are deemed struggling reproductive technology which involves specialist are the topics on “The IVF of 2030” like that of gamete selection, and time- collection of eggs from a woman before and “Automation in lapse. they mature, and undergo maturation ART and the future of process in lab. time-lapse technology”. He also mentioned that time-lapse (TL) technology is a better platform for Continue reading to page 2 embryo culture and has benefits beyond embryo selection. Some of these benefits he highlighted include the following: Inside Story TL provides more information with less handling leading to a more stable The Promise of Artificial Intelligence environment, which is an advantage 2 (AI) in Embryo Selection to clinics that overload or over-handle Q&A with South African animal As part of a company who offers innovative embryos; it is laboratory efficient, has robust 3 embryologist, Dr. Morne de la Rey IVF solutions in the laboratory, these topics KPIs and has readily available data. Another are indeed timely and relevant. Here is a benefit is that the use of TL contributes USA IVF Lab Equipment Installations summary of these two talks. to patient education by allowing shared 5 from July 20th thru July 24th experience with the patient. TL has better “The IVF of 2030”: Discussed by Dean quality control. Its most relevant benefit Esco and its “Trace, Test, and Treat Morbeck, the scientific director for Fertility is how it standardizes one practice and 6 Platform” Associates and is a lecturer at the University provides platform for innovation, like that Organizational Chart of Esco Medical: of Auckland, New Zealand. of AI (for optimal embryo development), 8 and non-invasive imaging. Asia Team According to Dr. Morbeck, one promising The New MAW 3-feet (0.9m) Model: concept is an “Automated IVF-in-a-Box”. Esco Medical takes pride of its MIRI® Time- 9 Small Footprint, Big Benefits As we become more advanced, the idea Lapse Incubator -- a multiroom incubator of automation has been constantly talked with a built-in camera and microscope. 10 Equipment Installations: about in almost every field. It is believed The MIRI® Time-Lapse Incubator provides South Africa “Tomorrow’s IVF Laboratory”: A Peek into the Future Continued from Page 1. and reducing errors. take into account.

Automation in IVF is actually not very As one of the authors of the ESHRE new as in today’s world. IVF clinicians and published article on “Good practice embryologists have been using some of recommendations for the use of time-lapse these tools already in their practice. Some technology”, Dr. Sfontouris further talked of these automated technologies include about these commendation covering robotics ICSI (for sperm immobilization, clinical and technical aspects of introducing aspiration, and insertion into oocyte), time-lapse in the IVF lab. microfluidics (for sperm analysis and selection modalities), vitrification, robotic Interestingly, Dr. Sfontouris mentioned the cryostorage, and time-lapse. current problems of TLT study designs. These include the incubator and the 2. The overall quality of culture systems will He also emphasized on “automated embryo selection software, which are not greatly improve through dynamic quality vitrification” – a robotic system for always distinguished in studies. Moreover, control and machine learning. automated equilibrium of oocytes and he said that microfluidics is promising as 3. Cleavage stage transfer and vitrification embryos in cryoprotectant solutions where it can possibly be combined with TLT – a retursn as part of ART arsenal. factors like temperature, volume and concept not yet fully explored and thus, 4. The cost of IVF will likely increase with concentration can be controlled during probably the future of IVF lab. automation but a significant increase in vitrification process. (Esco Medical is on effectiveness and safety would be noted. its way to developing its own AuVis -- True enough, scientific advancement in Automatic Vitrification Unit System -- that the field of embryology is a vast possibility. “Automation in ART and the future of will make a time-lapse image file of the And we at Esco Medical is just as excited time-lapse technology”: with Ioannis vitrification of the actual oocyte or embryo.) to develop more ground-breaking and Sfontouris as speaker. Dr. Sfontouris is forward-thinking solutions for the the director of Eugonia’s Embryology Lab Lastly, Dr. Sfontouris accentuated that betterment of our clients. in Athens, Greece. He has more than 19 time-lapse technology is the “ideal years of experience in the field of Assisted automation partner.” His discussion on TL In behalf of Esco Medical team, we extend Reproductive Technology. gave emphasis on the things one has to our utmost gratitude to the organizers cogitate in choosing TLT system. Factors of ESHRE and to all customers who have According to Dr. Sfontouris, automation is like cost, capacity, humidity, gas mixing, visited our online exhibit. needed for several reasons like saving time, culture media, lab workflows, algorithm, improving laboratory workflow, increasing type of microscopy, pH monitoring, and By: Mark Lester Sotelo assessment accuracy, procedure efficiency, the software – are considerations one must Esco Medical Product Specialist

The Promise of Artificial Intelligence (AI) in Embryo Selection

Will new AI-directed embryo selection truly improve outcomes, like result in he displayed his data on the results of their pregnancy and live birth, or will it only AI compared to that of their embryologist hasten the implantation process? Today, IVF is leaning more into non-invasive using a different approach. The data technologies for assessment of embryos showed that the AI performed better in Technological advancement is a with time-lapse technology and now with terms of ranking the blastocysts which continuously evolving process and is the development of Artificial Intelligence resulted to live birth. He also mentioned observed through everything with enough (AI) for various procedures. These include that with AI, it has to have a large database scientifically-backed data. This can also be egg, sperm, and embryo assessment with enough historical data to come up said with IVF throughout the years with the as predictors for successful live birth with a high probability prognosis on the birth of Preimplantation Genetic Testing outcomes. Esco Medical also has its own AI embryos for ranking. (PGT) and Intracytoplasmic Sperm Injection technology in development, the AuVis or (ICSI) in the past. Automated Vitrification Systems. Truly, AI provides an objective way of embryo selection to guide our embryologists or Embryo selection is an expected beginning IVF clinicians to come up with an efficient for the application of AI in the field of IVF, decision on choosing which embryos will hence it has piqued the interest of a vast give the best results. number of embryologists. The question remains on the efficiency and reliability of AI Esco Medical with its very own MIRI® Time- in attaining a successful live birth. This has Lapse Incubator will soon have this kind of been discussed by Dr. Alejandro Chavez- AI technology that will give our customers Badiola on a webinar entitled “Artificial the same benefits and provide them with a Intelligence and Embryo Ranking” where more in-depth analysis of the embryos. AuVis 2 MedNews Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 Q&A with Dr. Morne de la Rey

The Northern Rhinos need our help! – Hopes of reproducing a herd of Northern Rhinos when there are only two females left on the planet. Sudan, the world’s last male northern white rhino, died in March 2018 at a wildlife preserve in Kenya. Now the planet is left with only 2 female white rhinos, Najin and Fatu, and neither of them can carry a pregnancy. It seemed to be the end of the kind. Sad story. technique compared to IVF, 40 years ago. vitro culture, (3) fertilize them through ICSI I started my work on cattle reproduction using frozen-thawed sperm, (4) culture the and gradually worked more and more on fertilized embryos until blastocysts stage, wildlife. My early work was to work on and (5) transfer the blastocysts back to a artificial insemination of sable antelopes female rhino. in the early 90s. Then my team managed to clone a calf in 2003, the first animal in What is the most rewarding part of Africa. In 2016, we managed to reproduce your work? Cape Buffalo with In vitro fertilization, the first in the world. For the past few years, our Dr. De la Rey: There are many rewards. team has been exploring ways to reproduce Of course, the ultimate goal is to save Dr. Morné de la Rey with Sudan, the last Northern white rhino in the earth, in its last moment, after northern white rhinos by researching on In rhinos. I am passionate about wildlife. I am it contracted incurable infections in 2018. vitro fertilization of southern white rhinos. working on ways to harvest oocytes from live rhinos. So far, only me and another Dr. Morné de la Rey, a South African How to revive the northern rhinos scientist in Germany have been doing rhino veterinary surgeon and embryo transfer when there are no males left and only OPUs, so I spent quite some time designing specialist, is part of the international specialized probes to harvest oocytes from collaborative team working to revive rhinos. It took us 4 years to develop a probe Northern white rhinos with In vitro with which we are getting good results in fertilization. The Esco marketing team managed to have an interview with Dr. Morné de la Rey. two females living on the earth?

Oocytes extracted from live white rhino Katrien. There are very few embryologists Fertilization with frozen rhino sperms through dedicated to working in reviving retrieving oocytes. I call this model 13.7. ICSI (left) Embryo Incubation in embryo incubator Oocytes harvesting probe designed to fit rhino’s wildlife species with assisted (right) before transfer anatomy (top). reproductive technologies. What circumstances led you to this interesting Dr. De la Rey: We are developing IVF on Ultrasound of work? Southern rhinos, to study and optimize the a rhino ovary complete procedure until embryo transfer with multiple follicles Dr. De la Rey: I grew up in Africa and to achieve success on Southern Rhino, containing egg we have a passion for wild animals and so they can eventually be the surrogates of course passion for endangered species. cells. It must be to carry northern rhino embryos. The aspirated (left) My father was a veterinary surgeon. He procedure entails the following steps: started working on cattle and then Cape (1) collect oocytes from live rhinos with Buffalo embryo flushing, which is an older specialized probes, (2) mature the eggs In Continue reading to page 4 Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 MedNews 3 Q&A with Dr. Morne de la Rey Continued from Page 3.

Dr. Morné de la Rey and his team working on harvesting rhinos oocytes with the probe (right).

You also get to develop ways to mature the eggs and culture the embryos. Rhinos’ body temperature varies between 35 °C to 37 °C. So we need to experiment to figure out what temperature works best for rhino egg maturation, fertilization, and embryo incubation. We are also collaborating with San Diego Zoo Global and their support is remarkable.

It is all about passion.

Compared to human In vitro fertilization, which already has widely established protocols and guidelines to follow, your work seems to be challenging and open-ended. So share with us what for you is the most we have done a good job playing our believe in his brevity and creativity of doing challenging part of rhino IVF. part in preserving the species for future important yet challenging work on generations to come. If you are interested saving Rhinos through IVF. Dr. De la Rey: As you pointed out, there are in working or collaborating on some of the no established protocols or guidelines on projects we do, please do not hesitate to rhino IVF. So we need to develop our tools contact me. Contributions can be made and protocols using Southern rhinos as a to our research fund. Every donation to proxy, you cannot just Google it or order our research fund is also a great help in the equipment online. I have been doing preserving those species for our children. animal-assisted reproduction research for Please see our website, IG or FB here: the past 30 years and that is my passion and https://rhinorepro.org/ or scan QR code. I enjoy it despite the lack of resources. But Please share and spread the word around the biggest issue is funding. While there are the world. wildlife conservation funds available, those funds are normally available for species on the brink of extinction. By then, it is normally too late, like the northern white rhinos whereby the world is left with 2 females and some frozen sperm from a male. We could have a much higher chance to bring success in Animal IVF if we start working on

Words from Esco South Africa team: The funding for IVF research on endangered wildlife species in Africa is limited. Even for South Africa, which is one of the more them when there is still a sizable number. developed countries in Africa, funding is What do you wish to tell the audience still a big issue. It would be great to inform and our fellow embryologists? our global audience who are passionate about wildlife preservation to be aware Dr. De la Rey: I hope to raise more of Dr. de la Rey’s work. Please approach awareness on our cause, and to continue Dr. de la Rey if you wish to work on some working on ground-breaking assistive projects or collaborations. Our Esco team reproductive technologies to ensure the also donated a MIRI® embryo incubator to indefinite survival of white and black Dr. de la Rey’s lab, to show that we support rhinos. I hope we can, at the end of the day, this cause. We are inviting Dr. de la Rey for proudly tell our kids that as embryologists, a webinar (date to be released soon), as we

4 MedNews Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 USA IVF Lab Equipment Installations from July 20th thru July 24th

July 20-21st: Piedmont Reproductive Endocrinology Group P.R.E.G. - Greenville 17 Caledon Court, Ste. C, Greenville, SC 29615 Equipment: Installed 1 New MIRI® with SAFE Sens, and a new drawer stacking frame.

July 21-22nd: Piedmont Reproductive Endocrinology July 23-24th: Piedmont Reproductive Endocrinology Group - P.R.E.G. West Columbia Group - P.R.E.G. Mount Pleasant 2324 Sunset Blvd., West Columbia, SC 29169 1280 Hospital Drive, Suite 300, Mount Pleasant, SC 29464 Equipment: Installed 2 New MIRI® with SAFE Sens. Equipment: Installed 2 New MIRI® with SAFE Sens.

IVF Humor

Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 MedNews 5 Esco and its “Trace, Test, and Treat Platform” Health care professionals and have been offering tailored solutions that is working together with its collaborators biopharmaceutical companies fit the needs of different industries. With to develop a diagnostic and therapeutic worldwide are working at full the occurrence of the COVID-19 pandemic, platform against COVID-19. capacity the past couple of months. a number of companies worldwide has Medical workers have been untiringly become more assertive in coming up with Being an advocate of diagnostics, vaccines, treating an increasing number of COVID-19 innovative solutions that could contribute and pandemic therapeutics self-sufficiency, infected patients, while researchers and to the control of the spread of the disease Esco promotes a “trace, test, and treat scientists are determinedly (and quickly) through stringent healthcare system platform” to make mass testing possible, conducting various experiments to develop protocols that include comprehensive to actively isolate and to treat COVID-19 the right COVID-19 vaccine. A handful of mass testing, therapeutics, and vaccine positive patients. This approach aims to volunteers and other frontline personnel formulation studies. avert further risk for community spread. are delivering essential goods and services With this intention, an end-to-end platform to vulnerable people. These noble and Esco and its independent CDMO subsidiary, was developed to diagnose and treat the selfless acts of people around the globe Esco Aster, takes pride in being an innovation disease. have become sources of inspiration to - and solutions-oriented body, backed with everyone, that one day, we ultimately experienced engineers and scientists in TRACE, TEST survive this pandemic. the pharmaceutical and biotechnological The end-to-end platform commences sectors. Since the time patient zero was with the use of wheelchairs (Fig.1) and Esco, a world leading manufacturer of made known in last January 23, stretchers (Fig.2) designed to effectively laboratory and biopharma equipment, Esco Aster was kept up-to-date with efforts contain and transport the person under and IVF medical devices, through the years to control the then looming pandemic. In investigation (PUI) into a dedicated view of the current situation, Esco Aster emergency ambulance.

Fig. 1 Wheelchair Fig. 2 containment Stretcher containment

The PUI/s is/are then transported to an external diagnostic tent equipped with the latest Esco diagnostic sampling booth. 6 MedNews Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 Esco designed three types of COVID-19 mass testing booths:

Infectious Disease Streamline Diagnostic Swab TM Sampling Booth BoothTM TM Mass Screening (IDDSB ) (SSB) IDDSB™ provides Swab Booth™ SSBTM for HCW SSBTM for PUI airflow containment MSSB™ is designed (without glove ports) to capture and exhaust for mass swabbing of SSB™ is designed for the safe out aerosols from asymptomatic carriers and efficient testing of persons sputum expectoration, of the SARS-CoV-2 under investigation (PUI) and handling, sampling, virus. The booth persons under monitoring (PUM) or swabbing of asymptomatic carriers, PUIs, and comes with an in- with COVID-19 like symptoms. COVID-19 positive patients. This sampling booth built air ventilation It comes either as a positive thus eliminates exposure risk to harmful aerosols/ containment unit running in positive pressure (+ve) or negative single booth that airborne diseases. The unit can also be placed into a for healthcare worker protection and negative (-ve) can be utilized either indoors 20 ft. container with integrated biodecontamination pressure for the PUI’s side. MSSB™ is also equipped TM or outdoors with possibility systems utilizing hydrogen peroxide and are pressure SSB for PUI with close passing of swabs and onboard space for for a IP55 rating (minimum). decay tested under BSL 3 criteria. With its installation (with glove ports) optional systems such as cooler for cold chain, that Streamline swab booths are flexibility, IDDSB™ can be deployed in SARI Satellite stores swabs before they are transported to a nearby constructed with electrogalvanized steel with Esco Screening Facility alongside mobile Dx for end-to-end mobile or central diagnostic laboratory. Isocide™ antimicrobial powder coating that can also workflow. withstand disinfection/biodecontamination processes.

In its trace stage, Esco designed and for PUI booth; and for IDDSB™: -ve), strict patients, including sputum/lavage (saliva), created three COVID-19 booths: Infectious airflow regime, partnered with stringent thus, ensuring protection of the healthcare Disease Diagnostic Sampling Booth™ SOPs, Esco guarantees a safe and efficient workers and the environment. (IDDSB™), Mass Screening Swab Booth™ mass testing in each community to trace (MSSB™), and Streamline Swab Booth™ and diagnose all asymptomatic carriers In order to meet global need in terms of (SSB™), with the goal of diagnosing all PUI and Persons Under Investigation (PUIs) diagnosis and treatment, Esco offers the with COVID-19-like symptoms in a short with COVID-19-like symptoms, to prevent Aster Xpress™ where end-to-end platforms span of time while eliminating the risk further spread of the virus. are integrated into mobile containers of frontliners contracting the virus. With (available in 10’, 20’, and 40’ sizes). the booths’ programmed pressurization Furthermore, these booths are designed (MSSB™ & SSB™: +ve for HCW and -ve for repeat testing of COVID-19 positive

Such mobile diagnostic test laboratory is designed for virus-infected areas where specialized laboratory mechanical contractors are not present. These turnkey services make the diagnostic unit easy- to-deploy in situations where the medical provider desires to cover large areas and in situations where mobility of health services is desirable (through shifting demand). The Aster Xpress™ includes a complete set of equipment required in COVID-19 testing: Class II BSC, PCR cabinet, thermal cyclers, centrifuge, laboratory refrigerator and laboratory freezer, vortex shaker, autoclave, hand sink and eye wash station with Mobile Diagnostics Laboratory for Infectious Diseases integrated sterilization.

TREAT Recovery and Treatment Isolation Room™ Esco’s Unending World-class and Innovations under the treat platform aim (MRTIR™) to rapid self-assembly kits, and Worldwide Legacy to reduce healthcare-associated infections isolation containers available as: Modular Esco Medical and the entire Esco Group (HAIs), and bring about turnkey solutions 20’ Container, Modular 40’ Container and of Companies will continue to work to increase both patient and hospital Single 40’ Container Premium. persistently to hasten the development and treatment outcomes. innovation for flattening the curve of this Esco Aster is also working in partnership pandemic. With the surge of COVID-19 patients, with collaborators on monoclonal antibody existing healthcare facilities have been (mAb) antigen-based diagnostics and experiencing shortage in treatment spaces. a chimeric-based vaccine, which are As a solution, Esco designed modular expected to have successful outcomes in isolation rooms via the Esco Aster Airborne the fight against SARS-CoV-2. These will Infection Isolation (AIIR) Technology. This be processed via in-house scalable single- aims to provide turnkey treatment centers use bioreactors prior to further formulation (Esco Aster TTC) to reduce public health and filling. system exhaustion. Products under the Esco Aster AIIR Technology ranges from a stand-alone quick install Makeshift

Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 MedNews 7 Organizational Chart of Esco Medical: Asia Team

SINGAPORE

Bintan

Position Designation Position Designation Bangladesh Bintan, Indonesia Deputy Manager, Lab CSIS1 (Singapore, Joyonta Banik Medical Sales Astri Customer Service & Medical Latin America) Saiful Islam Senior Sales Executive Medical Sales CSIS2 (, Nisa Customer Service MENA) Tanvir Tauhid Senior Project Medical Service Engineer CSIS3 (Europe, Stany Goshami Pre-sales Coordinator Backoffice Support Althea Germany, Austria, Customer Service France, Italy) Jolly Ahmed Post-sales Coordinator Backoffice Support CSIS4 (Russia, East Md. Sazedur Rahman BDM Medical Service Mehran Africa, Indonesia, Customer Service Myanmar) LI jianjun Medical Sales Medical Sales CSIS5 (China, HK, Kendy , Macau, Customer Service Lei pengfei Medical Sales Medical Sales Taicang) Yang cheng Medical Sales Medical Sales Aldrin Africa Customer Service Cui ruwei Medical Service Medical Service Yudha Technical Specialist Technical Specialist Chen changjun Medical Service Medical Service Jonathan Olasiman Service Engineer Technical Specialist Sun yingming Medical Service Medical Service Senior purchaser Li qiuyuan Marketing Specialist Backoffice Support Inggit (placing order to EMT Order Processing Lithuania) Wu junhua Product Specialist Backoffice Support David Wang BDM Medical Sales Takeshi Matsumoto Sales Manager Medical Sales Hong Kong Toshinori Baba Service Engineer Medical Service Janice Yap BDM Medical Sales Miho Yamaguchi Communication Backoffice Support Arthur Tse Service Engineer Medical Service Malaysia Ng Kam Tong Service Engineer Medical Service Jason Tham BDM Medical Sales Indonesia Wendy Yong Sales Manager Medical Sales Kelvin Lim BDM Medical Sales Product Sales Henry Chi Sales Engineer Medical Service Hafizah Sepei Specialist Medical Sales 8 MedNews Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 The New MAW 3-feet (0.9m) Model: Small Footprint, Big Benefits Are you worried that your efficiency in the lab So as not to compromise the equipment’s Esco Medical’s scale-down version of MAW is be affected because it has limited space? Yet the quality and worth, Esco Medical is continuously an outright solution. True enough that small need for an essential workstation is inevitable. transforming the features and design of its footprint has big advantages. medical devices to fit and cater the needs of its Esco Medical launched the MAW 3-feet (0.9m) clients. These include ingenious compact-sized About the product model, a scale down version of our existing design as seen in Mini MIRI® Dry and Humidified Multi-Zone ART Workstation (MAW) is a laminar Multi-Zone ART Workstation during the last Incubators. flow workstation with temperature control week of July. and humidified working environment. this Likewise, Esco Medical came up with the new workstation is intended for work with gametes It is a reality that not all clinics and laboratories 3-feet model Multi-Zone ART Workstation and/or embryos at/or near body temparature have ample space for their equipment. Most of (MAW) intended to have smaller dimensions that conditions during In Vitro Fertilization (IVF) the time, these technologies require a significant will fit in a small laboratory space. or Assisted Reproductive Technology (ART) area for it to be accommodated. IVF laboratories treatments. The 3-feet model has the following with limited spaces may pose standard So if you have a start-up IVF clinic conducting specifications: equipment installation problems. the usual IVF, ICSI or andrology procedures, and is concerned with your minimal space,

Nominal Size 0.9 meter (3 FT) Internal Work area dimensions 955 x 500 x 710 mm (37.6” x 19.7” x 28.0”) (width x depth x height) External Dimensions without support stand 1035 x 640 x 1400 mm (40.8” x 25.2” x 55”) (width x depth x height) External Dimensions with “B“ type support 1035 x 640 x 2160 mm (40.8” x 25.2” x 85”) stand (width x depth x height) Cabinet Construction 1.2 mm (0.05”) gauge 18 electro-galvanized steel with Main Body White oven-baked Work Zone 1.5 mm (0.6”) gauge 16 stainless steel, grade 304 Side Walls Tempered Laminated Glass Shipping Weight 195 kg

Complete information about this model is found on our website. You can download the brochure at http://esco-medical.com or you could send us an e-mail at [email protected].

Position Designation Position Designation Malaysia (continued) Taiwan John Tan BDM Medical Sales Ashlyn Lim Product Sales Medical Sales Specialist Jason Chen Service Engineer Medical Service Product Sales Ooi Ying Shing Specialist Medical Sales Khattiya Sonsanam BDM Medical Sales Fehzie Service Engineer Medical Service Keerati Narach Service Manager Medical Service Muaz Service Engineer Medical Service Pre-sales customer Bongkoch (Bo) Backoffice Support service Ninoy Cahayon BDM Medical Sales Vietnam John Hyun BDM Medical Sales Denver John Paolo Service Engineer Medical Service Quiambao Chris Service Engineer Medical Service Regino Victorino Service Engineer Medical Service Timmy Service Engineer Medical Service Medical Product Mark Lester Sotelo Product Specialist Austin Service Engineer Medical Service Specialist Tony Service Engineer Medical Service Reginald Agsalon Marketing Marketing Product Sales Medical Product John Frederick Manalo Application Specialist Queen Support/ Sales Order Backoffice Support Specialist Processing Singapore Product Sales Sam Chiang Sales Executive Medical Sales Lily Support/ Sales Order Backoffice Support Processing Medical Product Meghan Peng Product Manager Service Sales Support/ Specialist Anna Backoffice Support Sales Order Processing Service Engineer Steve David Seow Medical Service Service Sales Support/ Manager Ivy Backoffice Support Sales Order Processing South Korea Order to Factory & Celina Backoffice Support Yoon Tae Hyun Sales Team Medical Sales Shipping Mark Lance Terrible Service Engineer Medical Service Kate Accounting Backoffice Support Keum Moon Seop Service Engineer Medical Service Stella Accounting Backoffice Support Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 MedNews 9 Equipment Installations: Esco’s South African office has successfully installed different Esco Medical products in medical institutions and clinics throughout South Africa Southern Africa. La Femme Fertility Clinic Dr. Pieta Geyser is the founder and owner of La Femme Fertility clinic, which is based in Rustenburg, North West. The installation was done in 2019. ® ® Equipment: CelCulture CO2 Incubator, MIRI Multiroom Incubator, Multi-Zone ART Workstation

Family Matters Fertility Centre Faculty of Veterinary Science In Vitro Is the first female-owned Fertility Clinic in South Africa. Dr. Qinisile Fertilization Lab Patricia Diale (founder and owner) partnered with embryologist, Mr Embryologist: Mario Smuts NHDip. Vet. Barth Tambwe to help their patients on the journey to parenthood. Tech., MSc. (Veterinary Science). Installation was done in December 2019. This installation was done in May 2020. Equipment: MIRI® Multiroom Incubator, CelCulture® CO Incubator, 2 Equipment: Anti-Vibration Table Multi-Zone ART Workstation

Sandton Fertility Clinic Managed by Dr. Goolam H Mohamed and Dr. Razina Patel (both Fertility specialists and Gynecologists) and Lab Director Prashan Mahraj. This Wijnland Fertility Clinic installation was done in 2018, with an addition of the Esco Mini MIRI® in Dr. Johannes and Lizanne van Waart are the proud 2019. Founders of Wijnland Fertility clinic, which is based in Affiliates of Sandton Fertility: Stellenbosch, Western Cape. This installation was done in December 2019. Dr. Wynand Van Tonder Dr. Alta Maphalala Associated clinicians: Dr. Khathu Mukhudwani Dr. Ilonda Mahoma Dr. Candice Morrison & Dr. Paul Dalmeyer Equipment: Multi-Zone ART Workstation, MIRI® Multiroom Incubator, Equipment: Mini MIRI® Incubator Mini MIRI® Incubator

Esco Medical successfully held its own virtual exhibit during the 10th - 14th of Augustus 2020. On behalf of the entire team, we thank everyone who visited and GRATITUDE POST supported our online exhibit. We hope to see you again in our next event.

Manufacturer: Manufactured for and sold under company trade mark: Esco Medical Technologies, Ltd. Esco Medical ApS Esco Micro Pte Ltd Draugystes g. 19, 51230 Kaunas, Lithuania Kringelled 10, 8250 Egå, 21 Changi South Street 1, Service address: Please contact your local Denmark Singapore 486777 distributor for details. Tel.: +45 53973067 Tel.: +65 6542 0833 @escomedical Users of Esco Medical products should not Fax: +65 6542 5732 hesitate to contact us if there are any unclear points or ambiguities in this newsletter. [email protected] www.esco-medical.com 10 MedNews Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020