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Download Newsletter Quarterly Newsletter | Issue 3 July - September 2020 MedNews If you want to know more... “Tomorrow’s IVF Laboratory”: A Peek into the Future Another edition of the annual that automation promises consistency, high quality time-lapse images of embryos ESHRE Meeting has culminated, safety, reliability (without the need for developing in “real-time” without having and although it was done virtually, more extensive training for embryologists), to remove the embryos from the safety and with the intention to improve access of the incubation chamber for manual it was still a success. Esco Medical to care. Despite being automated, this microscopy. Time-lapse embryo monitoring managed to participate in the kind of technology will not eliminate the provides detailed morphokinetic data online exhibit and to some of us; need for an embryologist. However, one throughout embryo development, which is we were able to catch up with primary issue that could possibly hinder not available on routine spot microscopic its acceptance is the obvious cost or evaluation. This allows all important events some scientific sessions inside the affordability. to be observed, helping to identify healthy comfort of our own homes (and embryos with the highest probability of offices). Dr. Morbeck also noted that the innovation implantation, with the aim of achieving we have seen in IVF the past years have higher pregnancy rates. One particular session that tickled our had varying impacts, ranging from those interest is about “Tomorrow’s IVF processes that have become key game Other predictions Morbeck mentioned in Laboratory”. Each session have several changers in the field as they have improved his talk include the following: speakers who discussed specific topics. implantation rates (like ICSI, blastocyst 1. In vitro maturation (IVM) will become a Notable discussions I find really thought- culture, and agonist ovulation triggers) to tool for selected patients. IVM is an assisted provoking and remarkable as a product those concepts that are deemed struggling reproductive technology which involves specialist are the topics on “The IVF of 2030” like that of gamete selection, and time- collection of eggs from a woman before and “Automation in lapse. they mature, and undergo maturation ART and the future of process in lab. time-lapse technology”. He also mentioned that time-lapse (TL) technology is a better platform for Continue reading to page 2 embryo culture and has benefits beyond embryo selection. Some of these benefits he highlighted include the following: Inside Story TL provides more information with less handling leading to a more stable The Promise of Artificial Intelligence environment, which is an advantage 2 (AI) in Embryo Selection to clinics that overload or over-handle Q&A with South African animal As part of a company who offers innovative embryos; it is laboratory efficient, has robust 3 embryologist, Dr. Morne de la Rey IVF solutions in the laboratory, these topics KPIs and has readily available data. Another are indeed timely and relevant. Here is a benefit is that the use of TL contributes USA IVF Lab Equipment Installations summary of these two talks. to patient education by allowing shared 5 from July 20th thru July 24th experience with the patient. TL has better “The IVF of 2030”: Discussed by Dean quality control. Its most relevant benefit Esco and its “Trace, Test, and Treat Morbeck, the scientific director for Fertility is how it standardizes one practice and 6 Platform” Associates and is a lecturer at the University provides platform for innovation, like that Organizational Chart of Esco Medical: of Auckland, New Zealand. of AI (for optimal embryo development), 8 and non-invasive imaging. Asia Team According to Dr. Morbeck, one promising The New MAW 3-feet (0.9m) Model: concept is an “Automated IVF-in-a-Box”. Esco Medical takes pride of its MIRI® Time- 9 Small Footprint, Big Benefits As we become more advanced, the idea Lapse Incubator -- a multiroom incubator of automation has been constantly talked with a built-in camera and microscope. 10 Equipment Installations: about in almost every field. It is believed The MIRI® Time-Lapse Incubator provides South Africa “Tomorrow’s IVF Laboratory”: A Peek into the Future Continued from Page 1. and reducing errors. take into account. Automation in IVF is actually not very As one of the authors of the ESHRE new as in today’s world. IVF clinicians and published article on “Good practice embryologists have been using some of recommendations for the use of time-lapse these tools already in their practice. Some technology”, Dr. Sfontouris further talked of these automated technologies include about these commendation covering robotics ICSI (for sperm immobilization, clinical and technical aspects of introducing aspiration, and insertion into oocyte), time-lapse in the IVF lab. microfluidics (for sperm analysis and selection modalities), vitrification, robotic Interestingly, Dr. Sfontouris mentioned the cryostorage, and time-lapse. current problems of TLT study designs. These include the incubator and the 2. The overall quality of culture systems will He also emphasized on “automated embryo selection software, which are not greatly improve through dynamic quality vitrification” – a robotic system for always distinguished in studies. Moreover, control and machine learning. automated equilibrium of oocytes and he said that microfluidics is promising as 3. Cleavage stage transfer and vitrification embryos in cryoprotectant solutions where it can possibly be combined with TLT – a retursn as part of ART arsenal. factors like temperature, volume and concept not yet fully explored and thus, 4. The cost of IVF will likely increase with concentration can be controlled during probably the future of IVF lab. automation but a significant increase in vitrification process. (Esco Medical is on effectiveness and safety would be noted. its way to developing its own AuVis -- True enough, scientific advancement in Automatic Vitrification Unit System -- that the field of embryology is a vast possibility. “Automation in ART and the future of will make a time-lapse image file of the And we at Esco Medical is just as excited time-lapse technology”: with Ioannis vitrification of the actual oocyte or embryo.) to develop more ground-breaking and Sfontouris as speaker. Dr. Sfontouris is forward-thinking solutions for the the director of Eugonia’s Embryology Lab Lastly, Dr. Sfontouris accentuated that betterment of our clients. in Athens, Greece. He has more than 19 time-lapse technology is the “ideal years of experience in the field of Assisted automation partner.” His discussion on TL In behalf of Esco Medical team, we extend Reproductive Technology. gave emphasis on the things one has to our utmost gratitude to the organizers cogitate in choosing TLT system. Factors of ESHRE and to all customers who have According to Dr. Sfontouris, automation is like cost, capacity, humidity, gas mixing, visited our online exhibit. needed for several reasons like saving time, culture media, lab workflows, algorithm, improving laboratory workflow, increasing type of microscopy, pH monitoring, and By: Mark Lester Sotelo assessment accuracy, procedure efficiency, the software – are considerations one must Esco Medical Product Specialist The Promise of Artificial Intelligence (AI) in Embryo Selection Will new AI-directed embryo selection truly improve outcomes, like result in he displayed his data on the results of their pregnancy and live birth, or will it only AI compared to that of their embryologist hasten the implantation process? Today, IVF is leaning more into non-invasive using a different approach. The data technologies for assessment of embryos showed that the AI performed better in Technological advancement is a with time-lapse technology and now with terms of ranking the blastocysts which continuously evolving process and is the development of Artificial Intelligence resulted to live birth. He also mentioned observed through everything with enough (AI) for various procedures. These include that with AI, it has to have a large database scientifically-backed data. This can also be egg, sperm, and embryo assessment with enough historical data to come up said with IVF throughout the years with the as predictors for successful live birth with a high probability prognosis on the birth of Preimplantation Genetic Testing outcomes. Esco Medical also has its own AI embryos for ranking. (PGT) and Intracytoplasmic Sperm Injection technology in development, the AuVis or (ICSI) in the past. Automated Vitrification Systems. Truly, AI provides an objective way of embryo selection to guide our embryologists or Embryo selection is an expected beginning IVF clinicians to come up with an efficient for the application of AI in the field of IVF, decision on choosing which embryos will hence it has piqued the interest of a vast give the best results. number of embryologists. The question remains on the efficiency and reliability of AI Esco Medical with its very own MIRI® Time- in attaining a successful live birth. This has Lapse Incubator will soon have this kind of been discussed by Dr. Alejandro Chavez- AI technology that will give our customers Badiola on a webinar entitled “Artificial the same benefits and provide them with a Intelligence and Embryo Ranking” where more in-depth analysis of the embryos. AuVis 2 MedNews Esco Medical | Quarterly Newsletter | Issue 3 July - September 2020 Q&A with Dr. Morne de la Rey The Northern Rhinos need our help! – Hopes of reproducing a herd of Northern Rhinos when there are only two females left on the planet. Sudan, the world’s last male northern white rhino, died in March 2018 at a wildlife preserve in Kenya. Now the planet is left with only 2 female white rhinos, Najin and Fatu, and neither of them can carry a pregnancy. It seemed to be the end of the kind. Sad story. technique compared to IVF, 40 years ago. vitro culture, (3) fertilize them through ICSI I started my work on cattle reproduction using frozen-thawed sperm, (4) culture the and gradually worked more and more on fertilized embryos until blastocysts stage, wildlife.
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