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NATO and NATO-Russia Nuclear Terms and Definitions
NATO/RUSSIA UNCLASSIFIED PART 1 PART 1 Nuclear Terms and Definitions in English APPENDIX 1 NATO and NATO-Russia Nuclear Terms and Definitions APPENDIX 2 Non-NATO Nuclear Terms and Definitions APPENDIX 3 Definitions of Nuclear Forces NATO/RUSSIA UNCLASSIFIED 1-1 2007 NATO/RUSSIA UNCLASSIFIED PART 1 NATO and NATO-Russia Nuclear Terms and Definitions APPENDIX 1 Source References: AAP-6 : NATO Glossary of Terms and Definitions AAP-21 : NATO Glossary of NBC Terms and Definitions CP&MT : NATO-Russia Glossary of Contemporary Political and Military Terms A active decontamination alpha particle A nuclear particle emitted by heavy radionuclides in the process of The employment of chemical, biological or mechanical processes decay. Alpha particles have a range of a few centimetres in air and to remove or neutralise chemical, biological or radioactive will not penetrate clothing or the unbroken skin but inhalation or materials. (AAP-21). ingestion will result in an enduring hazard to health (AAP-21). décontamination active активное обеззараживание particule alpha альфа-частицы active material antimissile system Material, such as plutonium and certain isotopes of uranium, The basic armament of missile defence systems, designed to which is capable of supporting a fission chain reaction (AAP-6). destroy ballistic and cruise missiles and their warheads. It includes See also fissile material. antimissile missiles, launchers, automated detection and matière fissile радиоактивное вещество identification, antimissile missile tracking and guidance, and main command posts with a range of computer and communications acute radiation dose equipment. They can be subdivided into short, medium and long- The total ionising radiation dose received at one time and over a range missile defence systems (CP&MT). -
Venom Week 2012 4Th International Scientific Symposium on All Things Venomous
17th World Congress of the International Society on Toxinology Animal, Plant and Microbial Toxins & Venom Week 2012 4th International Scientific Symposium on All Things Venomous Honolulu, Hawaii, USA, July 8 – 13, 2012 1 Table of Contents Section Page Introduction 01 Scientific Organizing Committee 02 Local Organizing Committee / Sponsors / Co-Chairs 02 Welcome Messages 04 Governor’s Proclamation 08 Meeting Program 10 Sunday 13 Monday 15 Tuesday 20 Wednesday 26 Thursday 30 Friday 36 Poster Session I 41 Poster Session II 47 Supplemental program material 54 Additional Abstracts (#298 – #344) 61 International Society on Thrombosis & Haemostasis 99 2 Introduction Welcome to the 17th World Congress of the International Society on Toxinology (IST), held jointly with Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, in Honolulu, Hawaii, USA, July 8 – 13, 2012. This is a supplement to the special issue of Toxicon. It contains the abstracts that were submitted too late for inclusion there, as well as a complete program agenda of the meeting, as well as other materials. At the time of this printing, we had 344 scientific abstracts scheduled for presentation and over 300 attendees from all over the planet. The World Congress of IST is held every three years, most recently in Recife, Brazil in March 2009. The IST World Congress is the primary international meeting bringing together scientists and physicians from around the world to discuss the most recent advances in the structure and function of natural toxins occurring in venomous animals, plants, or microorganisms, in medical, public health, and policy approaches to prevent or treat envenomations, and in the development of new toxin-derived drugs. -
Colchicine Acts Selectively in the Liver to Induce Hepatokines That Inhibit Myeloid Cell Activation
ARTICLES https://doi.org/10.1038/s42255-021-00366-y Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation Jui-Hsia Weng 1 ✉ , Peter David Koch1,2, Harding H. Luan3, Ho-Chou Tu4, Kenichi Shimada 1, Iris Ngan3, Richard Ventura3, Ruomu Jiang1 and Timothy J. Mitchison 1 ✉ Colchicine has served as a traditional medicine for millennia and remains widely used to treat inflammatory and other disor- ders. Colchicine binds tubulin and depolymerizes microtubules, but it remains unclear how this mechanism blocks myeloid cell recruitment to inflamed tissues. Here we show that colchicine inhibits myeloid cell activation via an indirect mechanism involv- ing the release of hepatokines. We find that a safe dose of colchicine depolymerizes microtubules selectively in hepatocytes but not in circulating myeloid cells. Mechanistically, colchicine triggers Nrf2 activation in hepatocytes, leading to secretion of anti-inflammatory hepatokines, including growth differentiation factor 15 (GDF15). Nrf2 and GDF15 are required for the anti-inflammatory action of colchicine in vivo. Plasma from colchicine-treated mice inhibits inflammatory signalling in myeloid cells in a GDF15-dependent manner, by positive regulation of SHP-1 (PTPN6) phosphatase, although the precise molecular identities of colchicine-induced GDF15 and its receptor require further characterization. Our work shows that the efficacy and safety of colchicine depend on its selective action on hepatocytes, and reveals a new axis of liver–myeloid cell communication. Plasma GDF15 levels and myeloid cell SHP-1 activity may be useful pharmacodynamic biomarkers of colchicine action. nflammation involves local activation and extravasation of circu- including signalling proteins termed hepatokines15. -
Homeland Security — Chemical, Biological and Radiological Warfare
NTIS Technical Reports Newsletter Homeland Security — Chemical, Biological and Radiological Warfare ADA483303 PB2009100141 Laboratory-Scale Study in Determining Attention Emergency Responders: Guidance the Decontamination Standards for on Emergency Responder Personal Protective Personnel Protective Equipment Used by Equipment (PPE) for Response to CBRN Homeland Defense Personnel: Evaluation (Chemical, Biological, Radiological, and of Commercial Off-the-Shelf Technologies Nuclear) Terrorism Incidents. for Decontamination of Personnel Protective National Institute for Occupational Safety and Equipment-Relevant Surfaces. Edgewood Health. Chemical Biological Center. 2008, 13p Department of Defense. DHHS/PUB/NIOSH-2008-132 2008, 19p Related Categories/Sub-categories: ECBC-TR-631 43D (Police, Fire, & Emergency Services) Related Categories/Sub-categories: 74D (Chemical, Biological, & Radiological 44G (Environmental and Occupational Warfare) Factors) 91I (Emergency Services & Planning) 57U (Public Health and Industrial Medicine) 95G (Protective Equipment) 74D (Chemical, Biological, & Radiological Warfare) PB2009106469 95G (Protective Equipment) Effectiveness of National Biosurveillance Sys- NTIS Technical Reports Newsletter tems: BioWatch and the Public Health System. ADA481190 Department of Homeland Security. Purpose: To bring you a sampling of the latest documents Public Health, Safety, and Security for Mass 2009, 30p added to the NTIS Database and to help you gain a greater Gatherings. Related Categories/Sub-categories: understanding of the -
FM 3-11. Chemical, Biological, Radiological and Nuclear Operations
)0 &KHPLFDO%LRORJLFDO 5DGLRORJLFDODQG1XFOHDU 2SHUDWLRQV MAY DISTRIBUTION RESTRICTION: Approved for public release; distribution is unlimited. 7KLVSXEOLFDWLRQVXSHUVHGHV)0GDWHG-XO\ HEADQUARTERS, DEPARTMENT OF THE ARMY Foreword As the Chemical Corps enters its second century of service in the United States Army, it must adapt to new threats and overcome 15 years of atrophy of chemical, biological, radiological, and nuclear (CBRN) skills within the Army that were attributed to operations in counterinsurgency. Throughout that time, the Chemical Corps approached the CBRN problem as it had for the past 100 years—avoid, protect, and decontaminate. These three insular capability areas provided a linear approach to detect existing hazards and offered a bypass of CBRN obstacles to enable the safe passage of forces. The approach to the CBRN program remained resistant to change, yet it ignored new forms of battle being exercised and conducted by major regional players (Russia, China, Iran, North Korea). The proliferation of new technologies, to include weapons of mass destruction (WMD) capabilities and materials, will remain a constant during the next 100 years. The Chemical Corps, in conjunction with the Army and joint force, must adapt and prepare for CBRN usage throughout the range of military operations. The Chemical Corps exists to enable movement and maneuver to conduct large-scale ground combat operations in a CBRN environment. Friendly forces must retain freedom of action and be capable of employing the full breadth of capabilities within complex battlefield conditions, including CBRN environments. The latest addition of FM 3-0 and the Army concept of multidomain operations outline the essential elements for success against peer and near-peer adversaries. -
Radiological Terrorism
Human and Ecological Risk Assessment, 11: 501–523, 2005 Copyright C Taylor & Francis Inc. ISSN: 1080-7039 print / 1549-7680 online DOI: 10.1080/10807030590949618 Radiological Terrorism P. Andrew Karam Department of Biological Sciences, Rochester Institute of Technology, Rochester, New York, USA ABSTRACT We run the risk that terrorists will decide to detonate an explosive device laced with radioactive materials (a radiological dispersal device, or RDD). If such an attack occurs, it is unlikely that the affected population or emergency responders would be exposed to high levels of external radiation, although airborne radionuclides may present a health risk under some circumstances. However, the effects of radia- tion and radioactivity are not well known among the general population, emergency responders, or medical personnel. This could lead to unwarranted panic, refusal to respond to the incident, inappropriately delaying or denying treatment to in- jured victims, and other unfortunate reactions during the emergency phase of any response. During the recovery phase, current regulations may lead to costly and restrictive radiation safety requirements over very large areas, although there have been recent efforts to relax some of these regulations in the first year following a radiological attack. The wide spread of radioactive contamination can also lead to environmental contamination, particularly in low-flow areas and near storm sewer discharge points, but the total radiation dose to the environment should not be excessively high in most locations. Key Words: RDD, dirty bomb, radiation, radiation health effects, terrorism, nu- clear weapons, radiological weapons. INTRODUCTION Since June 2002 we have become aware of the arrest of a suspected radiologi- cal terrorist (e.g., Warrington 2002), al Qaeda plans for constructing radiological weapons (El Baradei 2003), and the availability of large numbers (probably over 100,000) of “orphaned” radioactive sources in the world, thousands of which are sufficiently strong to cause harm (Gonzalez 2004). -
China's Role in the Chemical and Biological Disarmament Regimes
ERIC CRODDY China’s Role in the Chemical and Biological Disarmament Regimes ERIC CRODDY Eric Croddy is a Senior Research Associate at the Chemical and Biological Weapons Nonproliferation Program, Center for Nonproliferation Studies, Monterey Institute of International Studies. He is the author of Chemical and Biological Warfare: A Comprehensive Survey for the Concerned Citizen (New York: Copernicus Books, 2001). odern China has been linked with the prolif- least—and with considerable diplomatic effort—China eration of nuclear, chemical, and missile weap- broadcasts its commitment to both the CWC and the Mons technology to states of proliferation con- BWC. cern, and its compliance with arms control and disarma- Few unclassified publications analyze the role that CBW ment is seen as key to the effectiveness of weapons of have played in Chinese military strategy, nor is much in- 1 mass destruction (WMD) nonproliferation efforts. In this formation available on Beijing’s approach to negotiating context, the answer to Gerald Segal’s question, “Does CBW disarmament treaties. This is not surprising: China 2 China really matter?” is most definitely, “Yes.” In the is an extremely difficult subject for study where sensitive realm of chemical and biological weapons (CBW), military matters are concerned. A 1998 report by Dr. Bates Beijing’s role is closely linked to its view of the multilat- Gill, Case Study 6: People’s Republic of China, published eral disarmament regimes for CBW, namely the Chemi- by the Chemical and Biological Arms Control Institute, cal Weapons Convention (CWC) and the Biological and was the first to seriously address the issue of China and Toxin Weapons Convention (BWC), and of related mul- CBW proliferation. -
(12) United States Patent (10) Patent No.: US 9,174.999 B2 Du Bois Et Al
US009 174999B2 (12) United States Patent (10) Patent No.: US 9,174.999 B2 Du Bois et al. (45) Date of Patent: Nov. 3, 2015 (54) METHODS AND COMPOSITIONS FOR Arakawa O, Nishio S. Noguchi T. Shida Y and Onoue Y. A New STUDYING, IMAGING, AND TREATING PAIN Saxitoxin Analogue from aXanthid Crab Atergatis Floridus. Toxicon 1995; 33:1577-1584. (75) Inventors: Justin Du Bois, Palo Alto, CA (US); Dell'Aversano C. Walter JA, Burton IW. Stirling DJ, Fattorusso E and John Mulcahy, Stanford, CA (US); Quilliam MA. Isolation and Structure Elucidation of New and Brian Andresen, Menlo Park, CA (US); Unusual Saxitoxin Analogues from Mussels. J. Nat. Prod. 2008; David C. Yeomans, Sunnyvale, CA T1:1518-1523. (US); Sandip Biswal, Stanford, CA (US) Vale P. Metabolites of saxitoxin analogues in bivalves contaminated by Gymnodinium catenatum. Toxicon 2010; 55:162-165. (73) Assignee: The Board of Trustees of the Leland Koehn FE. Hall S, Wichmann CF, Schnoes HK, Reichardt PB. Stanford Junior University, Palo Alto, Dinoflagellate neurotoxins related to saxitoxin: structure and latent CA (US) activity of toxins B1 and B2. 1982; 23:2247-2248. Onodera H, Satake M, Oshima Y. Yasumoto T and Carmichael W.W. (*) Notice: Subject to any disclaimer, the term of this New Saxitoxin Analogues from the Freshwater Filamentous patent is extended or adjusted under 35 Cyanobacterium Lyngbya wollei. Natural Toxins 1997; 5:146-151. U.S.C. 154(b) by 277 days. Vale P. New Saxitoxin analogues in the marine environment: devel opments in toxin chemistry, detection and biotransformation during (21) Appl. No.: 12/800,053 the 2000s. -
HON 301 Welcome to the Anthropocene the Future of War
HON 301 Welcome to the Anthropocene The Future of War F. Walter November 2020 War Humans beings are natural predators • War seems a natural state of humanity • Are humans naturally tribal? • It is a means of expanding territory – Ants and chimpanzees do this too – Mongooses go to war to expand breeding stock: https://www.smithsonianmag.com/smart-news/warmongering-female- mongooses-lead-their-groups-battle-mate-enemy-180976265/ Costs of War • Human costs • Squandered resources • Economic costs – Unconsumed goods – Reconstruction costs Benefits of War War spurs innovation • Airplanes and Drones • Rocket technology • Computers • Medicine • Communications It’s a matter of survival! Innovations • Strength augmentation/exoskeletons – Medical uses • Drone technology – Economic spinoffs • Missile technology – Economic/scientific spinoffs • Remote sensing technology – Economic/scientific spinoffs Unintended Consequences • Reconstruction Threats • ICBM / SLBM threat requires near- instantaneous response • Warning systems are imperfect • Weapons systems are imperfect • Combat is “over the horizon” against an invisible enemy • Mistakes are fatal Biological Warfare • If you can create a serum, you can probably synthesize the toxin • Ability to manipulate genes has a dark side • Smallpox and Anthrax can be weaponized Radiological Warfare • Neutron Bomb – Neutrons penetrate armor • Dirty Bombs Other Threats Microwaves • Used recently by China against India • Considered for use in Afghanistan Infrasound/Ultrasound • What is affecting US attaché personnel in Havana? Cyber Warfare • The internet is insecure • The Internet of Things is vulnerable – Power plants – Transportation systems – Banks • State supported cyber attacks: – Russia, China, North Korea, and Iran Terrorism Abetted by: • Large, concentrated populations • Availability of weapons of mass destruction • Conspiracy theories There are tradeoffs between liberty and security. -
(CBR) WARFARE 8(2 C Z
tí Ao.e.s DEPARTMENT OF THE ARMY FIELD MANUAL gfereneé "¿$; JÍ./A-/ t/ TACTICS AND TECHNIQUES \ OF CHEMICAL, BIOLOGICAL AND RADIOLOGICAL (CBR) WARFARE 8(2 c z HEADQUARTERS, DEPARTMENT .OF THE ARMY \ NOVEMBER 1958 io 1979C—oct The Pentagon Library Km 1A518, Pentagon Waahinston, D.a 2081O *FM 3-5 EJELD MANUAL ) HEADQUARTERS, l DEPARTMENT OF THE ARMY No. 3-5 ) WASHINGTON 25, D. C., 5 November 1958 TACTICS AND TECHNIQUES OF CHEMICAL, BIOLOGICAL, AND RADIOLOGICAL (CBR) WARFARE Paragraphs Page CHAPTER 1. INTRODUCTION TO 1-4 3 CHEMICAL, BIOLOG- ICAL, AND RADIOLOG- ICAL (CBR) WARFARE. 2. RESPONSIBILITIES FOR CBR WARFARE Section I. Department of Defense 5-8 6 II. Branches of the Army 9-11 7 III. Command responsibilities and 12-16 12 staff functions. CHAPTER 3. CHARACTERISTICS OF CHEMICAL AGENTS AND MUNITIONS Section I. Terminology of chemical 17-31 Id warfare. II. Chemical agents 32-36 20 III. Methods of dissemination 37-41 23 IV. Effects of weather 42-46 27 V. ,- Effects of terrain 47-50 31 CHAPTER Ai CAPABILITIES AND TECHNIQUES FOR EM- PLOYMENT OF TOXIC CHEMICAL AGENTS ' This manual supersedes FM 3-5, 1 September 1954, including C 1, 12 February 1957. AGO 1979C 1 IParagrapha PaKe Section I. Capabilities 51-56 36 II. Chemical attack for nonper- 57-59 39 sistent effect. III. Chemical attack for persist- 60-62 43 ent effect. IV. Fire planning 63,64 46 V. Troop safety 65-11 49 CHAPTER 5. CAPABILITIES AND TECHNIQUES FOR EM- PLOYMENT OF SMOKE AND FLAME Section I. Smoke 72-77 58 II. Flame 78-85 65 CHAPTER 6. -
Taxonomic Identification of Pathogenic Micro-Organisms and Their Toxic Proteins
Europäisches Patentamt *EP001308520A2* (19) European Patent Office Office européen des brevets (11) EP 1 308 520 A2 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.7: C12Q 1/04, G01N 33/68, 07.05.2003 Bulletin 2003/19 G01N 33/542, G01N 33/543, G01N 33/50 (21) Application number: 02021593.5 (22) Date of filing: 27.09.2002 (84) Designated Contracting States: (72) Inventors: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR • Powers, Linda S. IE IT LI LU MC NL PT SE SK TR Logan, Utah 84321 (US) Designated Extension States: • Ellis, Walther R., Jr. AL LT LV MK RO SI Logan, Utah 84321 (US) • Lloyd, Christopher R. (30) Priority: 01.11.2001 US 999159 Logan, Utah 84341 (US) (71) Applicant: MicroBioSystems Limited Partnership (74) Representative: Bauer, Wulf, Dr. Cheyenne, Wyoming 82001 (US) Bayenthalgürtel 15 50968 Köln (Marienburg) (DE) (54) Taxonomic identification of pathogenic micro-organisms and their toxic proteins (57) The present invention describes a method for teins, outer membrane proteins and conjugated lipids. the binding of pathogenic microorganisms and their tox- Non-binding components of the solution to be analyzed ic proteins with ligands that have been covalently teth- are separated from the bound fraction and binding is ered at some distance from the surface of a substrate: confirmed by detection of the analyte via microscopy, distances of at least fifteen Å are required for microor- fluorescence, epifluorescence, luminescence, phos- ganism binding ligand tethers and at least six Å are re- phorescence, radioactivity, or optical absorbance. By quired for protein binding ligand tethers. -
GAO-08-180 Homeland Security: First Responders' Ability to Detect And
United States Government Accountability Office Report to Congressional Requesters GAO June 2008 HOMELAND SECURITY First Responders’ Ability to Detect and Model Hazardous Releases in Urban Areas Is Significantly Limited GAO-08-180 June 2008 HOMELAND SECURITY Accountability Integrity Reliability ighlights First Responders’ Ability to Detect and Model H Hazardous Releases in Urban Areas Is Significantly Highlights of GAO-08-180, a report to congressional requesters Limited Why GAO Did This Study What GAO Found First responders are responsible While the Department of Homeland Security (DHS) and other agencies have taken for responding to terrorist-related and accidental releases of CBRN steps to improve homeland defense, local first responders still do not have tools to materials in urban areas. Two accurately identify right away what, when, where, and how much chemical, biological, radiological, or nuclear (CBRN) materials are released in U.S. urban areas, primary tools for identifying agents released and their dispersion and accidentally or by terrorists. Equipment local first responders use to detect effect are equipment to detect and radiological and nuclear material cannot predict the dispersion of these materials in the atmosphere. No agency has the mission to develop, certify, and test equipment identify CBRN agents in the environment and plume models to first responders can use for detecting radiological materials in the atmosphere. track the dispersion of airborne According to DHS, chemical detectors are marginally able to detect an immediately dangerous concentration of chemical warfare agents. Handheld detection devices for releases of these agents. GAO reports on the limitations of the biological agents are not reliable or effective.