Invitasjon Til Å Foreslå Nye Medlemmer I Bioteknologirådet

Til Legeforeningen her Oslo, 16.07.2018

Høring- Invitasjon til å foreslå nye medlemmer i Bioteknologirådet

Styret i PSL har behandlet saken og vil i den anledning foreslå som nye medlemmer i Bioteknologirådet:

styremedlem Dag Malm og medlem Even Holt

CV for begge de foreslåtte kandidatene følger vedlagt (se de påfølgende sider).

For styret i Praktiserende spesialisters landsforening /PSL

Frøydis Olafsen leder

Praktiserende spesialisters landsforening • Postboks 1152 Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2 Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro 5074.09.95615

CURRICULUM VITAE Updated: Jan 15th 2017

Dr. med. Dag MALM (Last name Jacobsen until 021085), Born July 1th 1953 in Tromsø, Norway: Citizenship: Norwegian Civil status: Married Children: 3 (Range 25-33 years, Mean 28 years) Languages spoken: Scandinavian, English and German (fluently). French and Spanish (poorly).

Education: University Qualifying Examination, Kongsbakken College, Tromsø, 1971. Final Examination in Medicine, University of Göttingen, Germany 1977 (2.part) and 1978 (Final part). Norwegian Additional Examination at the Universitety of Oslo mars 1976. License to practice as a Medical Doctor: Spring 1978 (Germany) and 1980 (Norway). Specialist in internal medicine 1985. Specialist in digestive tract disorders (Gastroenterology, Hepatology and Endoscopy combined) 1990. Doctoral Degree 1995 on the topic "Studies on the intracellular regulation of insulin secretion in pancreatic islets: An experimental study with special reference to the effect of cholecystokinin, somatostatin, and galanin on the hydrolysis of phosphatidyl inositol."

Service in hospitals: - District General Hospital Alfeld, Germany, Dept. Surgery, Intern 020577-310777 3 months. - District General Hospital Alfeld, Germany, Dept. Medicine, Intern 010877-301177 4 months. - University Clinic of Göttingen, Germany, Dept. Paediatrics, Intern 011277-310378 4 months. - Hospital Bad Gandersheim, Germany, Dept. Medicine, Junior Registrar 010678-300679 13 months. - Hospital Harstad, Norway, Dept. Medicine, Junior Registrar 030881-311283 29 months. - District General Hospital Vestfold, Tønsberg, Norway, Dept. Medicine, included 12 moths Gastroenterology Senior Registrar 150284-310586 28 months. - University Hospital of North Norway (UNN), Tromsø, Dept. Medicine, Sektion of Gastroenterology Senior Registrar 150889-150990 13 months. - University Hospital of North Norway (UNN), Tromsø, Dept. Medicine, Sektion of Gastroenterology Chief Physician 290791-151191 4 months. - University Hospital of North Norway, Tromsø (UNN), Dept. Medicine, Sektion of Gastroenterology Chief Physican, Section leader 161191-160893 30 months. 010694-010495 10 months. 010995-011096 13 months.

Chief Physician/ Senior Consultant 011097-311207 122 months. SUM 267 months.

Service outside institutions in Norway: - Intern on Røst 150779-140180 6 months. - District Medical Officer in Røst 150180-100280 1 month. - District Medical Officer in Storfjord 150480-150880 4 mnd. - District Medical Officer in Bjarkøy 160880-150881 12 mnd. - Evening work Medical Practice (20%) 1986-2007 96 mnd - MD Tromsø Centre Internal Medicine 2008- still SUM 204 mnd.

Educational qualifications: - Educational Seminar, University of Tromsø 1987. - Course in Counselling, The Norwegian Medical Association (NMA), 1993 and 1994. - Sporadic education of nurses, farmacists or other medical personell in Bad Gandersheim, Tønsberg og Tromsø 1978-2007. - Leader of Basic courses in Medicine 2003-2007. - Leader of ca. 20 University courses, such a s. "Basic Course in Biomedical Research” from 1989 till 2001. - University of Tromsø, Institute of Clinical Medicine: Lecturer Internal Medicine 010686-140889 39 mnd. 160990-280791 10 mnd. Assistant Professor in Medicine 011096-311606 122 mnd SUM 181 mnd. Guided 6 students in medicin or basic course of medicin through their post-graduate thesis.

Administrative qualifications/ Commissions: - Student Council Leader Kongsbakken College, Tromsø, 2 periods 1970-71 - Representative for Scientific Intermediate Positions, Board of Medicine, University of Tromsø 1986-88. - Member at the Board of the Medical Department, UNN, 1988-1990. - Chief Physican, Section leader (Const), Gastroenterological section, Dep. Medicine, UNN 1991 through 1996. - Course in Administration 1, 3 and Modul A and B, NMA 1992-94. - Member North-Norwegian Gastroentereological Society 1992-1996 - Member Speciality Committee for Digestive Diseases 1994- 1998 and 2010-2014. - Leader Speciality Committee for Digestive Diseases 1998- 2010 - Employee representative Senior Consultants, Dept. Medicine, 1996 og 2005-Still - Coordinator Basic courses in Medicine, University in Tromsø 1997-06 - Coordinator Last year of Study in Medicine, Med. Fac., University in Tromsø 2003 - Professional Responsible Basic courses in Medicine 2004-06 - Member Scientific Advisory Board in “The International Society of Mannosidosis” 1998- Still www.ismrd.org - Member Union of Medical Specialists- European Board of Gastroenterology 2006- 2010 - Deputy of the Training Recognition Committee UEMS http://www.eubogh.org/gastroeums/ 2008-2010

- Fellow of the European Board of Gastroenterology and Hepatology 2010 - Recognized Reviewer Status: Molecular Genetics and Metabolism 2015 - Medical Consultant for Rare Diseases Chiesi Comp http://www.chiesigroup.com/en/rare-diseases

Endoscopy practice (pr 2015): Gastroskopies ca. 20.000 Colonoskopies ca. 10.000 ERCP ca. 200 External abdominal ultrasound ca 40.000

Course supervisor for The Norwegian Medical Association (NMA): - Basic Course in Biomedical Research, Tromsø 1989-2001 - Motility Disturbances of the GI-tract, Tromsø 1993 - Food intolerance and allergy, Harstad 1994 - Ulcerous colitis, Hammerfest 1995 - Liver Diseases, Bodø 1995 - Internal Medicine towards 2000, Tromsø 1999 - Gut Diseases, Tromsø 1999 - Internettcourse for candidates in gastroenterology 2003 and 2004 - Internettcourse in gastroenterology for candidates in internal medicine 2007-2008

Invited presentations: Irritable Bowel Syndrome. North Norwegian Gastroenterological Society, Tromsø 1993. Coeliachi and lactose intoleranse. North Norwegian Gastroenterological Society, Harstad 1994. Differential diagnosis in IBD. North Norwegian Gastroenterological Society, Hammerfest 1994. Medical treatment of peptic ulcer in Norway. Joint meeting of North-Norwegian Society og Gastroenterology and Arkhangelsk Region Society of Gastroenterologists, Archangelsk 1994. Malabsorption and pankreatic insuffitiens. North Norwegian Gastroenterological Society, Tromsø 1999. Anti-TNF in Mb Crohn. Indremedisinsk høstmøte, Oslo 1999. Chestpain from the gastroenterological angle. AZ Academy, Tromsø 2000. Azathioprin in IBD. AZ Academy, Porto, Portugal 2000. Stomach pain. AZ Academy, Tromsø, Norway 2001. Anti-TNF in Mb Crohn. North Norwegian Gastroenterological Society, Tromsø 2001. Second opponent Dr. med thesis, Solomon Tefera, Dept. Medicine, Haukeland University Hospital, Bergen, Norway 2001 Treatment of chronical pancreatitis. Norwegian Pankreas Club, Oslo 2004 Living with mannosidosis. 1st International meeting on glycoproteinosis, Washington 2004 The Natural Course and Complications of Alpha-Mannosidosis. 2nd meeting on glycoproteinosis, Ann Arbor 2007 The Tromsoe Story on Alpha-Mannosidosis. 4th International meeting on glycoproteinosis, St. Louis 2015

Participation in conferences – internasjonal: 1th United European Gastroenterology Week 19-23. okt 1991. Athens, Greece. 6th United European Gastroenterology Week 2-4. nov 1996. Paris, France. 9th United European Gastroenterology Week 12-14. nov 1999. Rome, Italy. Kick-off meeting on the EU consortium project: “A systematic and multidisciplinary approach towards understanding and therapy of the inborn lysosomal storage disease alpha- mannosidosis (EURAMAN). September, 2001, Woudschoten, Nederland 11th United European Gastroenterology Week 19-23. okt 2001. Brussel, Belgia. 13th United European Gastroenterology Week 1-4. nov 2003. Madrid, Spain 14th European Study Group on Lysosomal Diseases (ESGLD) Workshop. 20-23 September 2003. Podebrady, Chech Republic. Kick-off meeting on the EU consortium project:”HUE-MAN” 2006, Kiel, Germany International Congress on Internal Medicine, 10-13. Nov 2006.Taipei, Taivan 18th United European Gastroenterology Week 23-25. okt 2010. Barcelona, Spain 19th United European Gastroenterology Week 23-25. okt 2011. Stockhom, Sweden Kick-off meeting on the EU consortium project:”ALPHA-MAN” 2010, Kiel, Germany 20th United European Gastroenterology Week 23-25. okt 2012. Barcelona, Spain 21th United European Gastroenterology Week 1-3. nov 2013. Berlin, Germany 22th United European Gastroenterology Week 20-23. okt 2014. Vienna, Austria 23th United European Gastroenterology Week 25-28. okt 2015. Barcelona, Spain

Arrangement Congresses: - Member Organising Committee and Scientific Committee for International Congress in Tromsø 1996 (Scandinavian Society for the Study of Diabetes). Editorial board Acta endocrinologica 1996 - Member Scientific Committee International Congress GASTRONOR, Tromsø 1999 - HUE-MAN meeting Coastal Steamer 2009 Bodø-Tromsø - Member Scientific Committee on the 5tth International Congress on Glycoproteinosis, Rome 2017

Scientific Guidance: ”Treatment of Helicobacter pylorii at UNN”, Tone Pedersen 1993 (Stud Basic Med) ”The effect of glucose on the release of cAMP in perifused pancreatic islets”, Eyvind Grimstad 1995 (Stud med) ”Gastroenterological flashback”, Barbro Johansen 1996 (Stud Basic Med) ”Liver biopsy. Blind biopsi with Menghini contra ultrasound giuded biopsy with True-Cut”, Peggy Elise Sivertsen 1998 (Stud Basic Med) ”A study of Chase Christophers Childrens Hospice i Guilford, UK”, Lena Kristin Nerdal og Silje Kristine Heitmann 2003 (Stud med)

Participation in international Research Cooperation Alpha-mannosidosis: I was involved as partner in the EU prosject EURAMAN: “A Systematic and Multidisciplinary Approach Towards the Understanding and Therapy of the Inborn Lysosomal Storage Disorder Alpha-Mannosidosis”. I am involved as one of 11 Group leaders in the EU prosjektet: HUE-MAN: “Towards the Development Of an Effective Enzyme Replacement Therapy For Human Alpha-Mannosidosis” http://www.uni-kiel.de/Biochemie/hue-man/ http://www.uni-kiel.de/Biochemie/hue-man/partners/partner8.htm . Other cooperating partners in the HUE-MAN consortium: Paul Saftig, University of Kiel, Germany. Michael Beck, Mainz, Germany. Kurt von Figura, Universitetet of Göttingen, Germany Ed Wraith, Manchester, United Kingdom Aldo Orlacchio, University of Perugia, Italy. Tommaso Beccari, University of Perugia, Italy Sean McSweeney, Univeristetet of Grenoble, France Jean Claude Michalski, Universitetet of Lille, France Jean Pierre Zanetta, Univeritetet of Lille, France Rene Cacan, Universitetet of Lille, France Jens Fogh, Zymenex, Copenhagen/ Stockholm, Denmark/Sweden Øivind Nilssen and Hilde Monica Frostad Riise, University of Tromsø, Norway. Own partners: Johannes Pantel, Mainz, Germany, and Olav Linaker, Trondheim, Norway. Partner in the ALPHA-MAN consortium, http://www.alpha-man.eu/

Reseach activity: After a period of reseach on gastrointestinal peptide hormones supervised by prof. Per G. Burhol (1986-1987), I consentrated on studier in isolated pancreatic islets and their secretory responses on metabolic, hormonal, and pharmacological stimuli with prof. Jon Florholmen as supervisor. 1989 I established a method for the separation and measurement of inositol metabolittes. Since then reaseach focused on intracellular signal transduction in beta cells of the pancreatic islets, leading to my Doctoral Degree 1995 on the topic "Studies on the intracellular regulation of insulin secretion in pancreatic islets: An experimental study with special reference to the effect of cholecystokinin, somatostatin, and galanin on the hydrolysis of phosphatidyl inositol."

In addition to research in endocrinology, I have investigated genetic, biochemical, and clinical aspects of the lysosomal storage disease Alpha-mannosidosis with focus on detection of mutations, genotype-phenotype correlations, immunodeficiency, autoimmunity, and enzyme replacement therapy. In 1992 I established ”The Tromsø Mannosidosis Group” together with the profs Øivind Nilssen and Ole Kristian Tollersrud. This have led to the charakterisation of the AA sequence, structure and 3D structure of the enzyme in man, cattle, cat, whale, cod, birds,

kenguru and hare. The group has described more than 100 of the first disease causing mutations. The HUE-MAN and ALPHA-MAN consortium resulted in enzyme replacement therapy (ERT) for Alpha-Mannosidosis.

Extern funding:

Fund from Norske Hoechst, from «Dr. Trygve Gythfeldt og frues forskningsfond», «foreningen for muskelsyke», «forsknings- og reisestipend fra diabetesforbundet» og «klinisk lønnsstipend fra NAVF» i tiden 010693-94 og lønnsstipend fra «Gastroenterologisk Forskningsfond 0104-300895».

Dag Malm. Funding from European Commission (EU) fra programmet: ”Quality of Life and Management of Living Resources,” 1999/C 361/06. Prosjekttittel: “A Systematic and Multidisciplinary Approach Towards the Understanding and Therapy of the Inborn Lysosomal Storage Disorder Alpha-Mannosidosis”. Total tildeling: 1.580.000 ECU (12.800.000 NOK) over 3 år, totalt 10 partnere. Dag Malm er gruppeleder for Work-packgage 8: ”Natural Course Study of Alpha- Mannosidosis”. Samt medarbeider på 3 andre delprosjekter. Avdelingens tildeling utgjør 1.226.000 NOK over 3 år.

PUBLIKASJONSLISTE DAG MALM Oppdatert: Jun 1., 2016-12-17

INVITED REVIEWS

Malm D, Nilssen O. Alpha-Mannosidosis (October 2005 through 2008) In: GeneReviews: Clinical Genetic Information Resource [database online]. Copyright, University of Washington, Seattle. Available at http://www.geneclinics.org.

Dag Malm and Øivind Nilssen. Alpha-mannosidosis Orphanet Journal of Rare Diseases 2008, 3:21 (23 July 2008) Available at http://www.ojrd.com/content/3/1/21

Malm D. Title: Alpha-mannosidosis NORD Guide to Rare Disorders Publisher: Lippincott, Williams & Wilkins, Philadelphia, PA Date Summer 2001 through 2015

PAPERS

Florholmen J, Riepl R, Almdahl S.M., Myklebust R, Burhol PG, Giecksky K-E, Malm D. Impact of experimental endogenous gram-negative peritonitis of the pancreas of the rat as evaluated by cationic trypsin-like immunoreactivity in peritoneal fluid and serum and by electron microskopy of pancreatic tissue. Scand J Gastroenterol 1987, 22, 313-320

Florholmen J, Malm D, Vonen B, Burhol PG. The effect of cholecystokinin on the accumulations of inositolphosphates in isolated pancreatic islets. American Journal of Physiology, 1989, 261, G 865-70

Malm D, Vonen B, Burhol PG & Florholmen J. The interaction between cAMP-dependent and cAMP-independent mechanisms in mediating the somatostatin inhibition of insulin secretion in isolated rat pancreatic islets. Acta Physiol Scand, 1991, 143 (3),

Malm D, Giæver A, Vonen B, Burhol PG & Florholmen J. Somatostatin inhibition of phospholipase C activity in isolated rat pancreatic islets. Acta Physiol Scand, 1991, 143, 413-419.

Vonen B, Florholmen J, Giæver AK, Malm D, Burhol PG. The effect of arginine on the insulin secretion in rat pancreatic islets. Acta Physiol Scand, 1992,.

Vonen B, Florholmen, Malm D, Burhol PG. Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets. Scand J Clin Lab Invest, 1992, 52, 107-12.

Vonen B, Florholmen J, Malm D, Burhol PG. Sorbitol in isolation of rat pancreatic islets. Effects on islet yield, insulin secretion and phospholipase C activity. Scan J Clin Lab Invest, 1992, 52, 237-43.

Giæver AK, Haukland Huson H, Bertinussen A, Vonen B, Malm D, Huseby NE, Florholmen J. Phosphoinositide metabolism in a polyoma-BK-virus transformed pancreatic islet cell line: Evidence for constitutively activated phospholipase C. Int J Cancer 1993, 53, 80-86.

Malm D, Giæver A, Vonen B, Florholmen J. Cholecystokinin and somatostatin modulate the glucose-induced insulin secretion by a different mechanism in pancreatic islets. A study on phospholipase C activity in isolated rat pancreatic islets and calcium requirement. Scan J Clin Lab Invest 1993, 53, 671-76.

Malm D, Tollersrud OK, Tranebjærg L, Månsson JE. Alfa-mannosidose. Tidsskr Nor Lægeforr 1995, 115, 594-97.

Giæver AK, Husom Haukland HJ, Paulssen RH, Vonen B, Malm D, Florholmen J. Are the inhibitory effects of somatostatin and lithium on malignant cell growth mediated via phosphatidyl inositol metabolism? Submitted.

Malm D, Tollersrud OK, Vonen B, Florholmen J. The effect of fructose metabolism on the accumulation of inositol phosphates in pancreatic islets. Scan J Clin Lab Invest, 1996.

Lindskog S, Malm D, Florholmen J, Ahrén B. The effect of cholecystokinin on proinsulin gene expression in isolated mice pancreatic islets. Pancreas, 1996, 13 (4), .

Andersen K, Malm D, Olaffson S. Duplexsonography and colour doppler in the diagnosis and follow-up of portal vein thrombosis. Eur J Ultrasound, 1996, 3, 33-40.

Malm D, Lindskog S, Ahrén B, Florholmen J. Galanin exerts dual action on phospholipase C activity in isolated pancreatic islets. Endocrine Journal, 1997, 44/2, 283-88.

Nilssen Ø, Berg T, Riise HMF, Ramachandran U, Evjen G, Hansen GM, , Malm D, Tranebjærg L, Tollersrud OK. Alpha-mannosidosis: Functional cloning of the alpha- mannosidase gene and identification of a mutant in affected siblings. Hum Mol Genet 1997, 6, 717-26 (Gene Bank Accession Code # HSU60266)

Riise HMF, Berg T, Hansen GM, Tollersrud OK, Malm D, Tranebjærg L, Nilssen Ø. Spectrum of mutations in human alpha-mannosidosis. Am J Hum Genetics 1999, 64, 77-88.

Hovdenak N, Aadland E, Stokkeland M, Hausken T, Malm D. Inflammatorisk tarm. Therapia Medica. 1999, 5, 10.

Malm D The Road So Far: The Tromsoe Mannosidosis Group Pathways 2000, 2, 3

Malm D, Halvorsen D, Tranebjærg L, Sjursen H. Characterization of the immunodeficiency in alpha-mannosidosis. A matched case-control study on immunoglobulins, complement factors, receptor density, phagocytosis, and intracellular killing in polymorphonuclear leucocytes. European Journal of Pediatrics 2000, 159, 699-703.

Urushihara M, Kagami S, Yasutomo, Ito M, Kondo S, Kitamura A, Malm D, Klenow H, Nilssen O, Kuroda Y. Sisters with alpha-mannosidosis and systemic lupus erythematosus. European Journal of Pediatrics 2004, 159, 699-703.

Malm D, Pantel J, Linaker OM. Psychiatrich symptoms in alpha-mannosidosis. Journal of Intellectual Disability Research 2005, 49, 865-871

Henri de la Salle1*, Sabrina Mariotti2*, Catherine Angenieux1*, Martine Gilleron3*, Luis Fernando Garcia-Alles4, Dag Malm5, Thomas Berg6, Samantha Paoletti2, Blandine Maître1 Lionel Mourey4, Jean Salamero7, Jean Pierre Cazenave8, Daniel Hanau1, Lucia Mori2, Germain Puzo3†, Gennaro De Libero2† Assistance of microbial glycolipid antigen processing by CD1e. Science. 2005 Nov 25;310(5752):1321-4.

D Avenarius, JS Svendsen, D Malm Proton Nuclear Magnetic Resonance Spectroscopic Detection of oligomannosidic N glycans in Apha-Mannosidosis: A Method of monitoring treatment? J Inher Met Dis 2011; 34 (5):1323-27

M Myranek, M Albert, JJ Boelens, JS Kuehl, A Glomstein, D Malm, T Lücke, KW Sykora Allogeneic hematopoetic SCT for alpha-mannosidosis.

Bone Marrow Transplant 2012; 47 (3):352-9

Stensland HMFR, Klenow HB, Van Nguyen L, Hansen G, Malm D, Nilssen Ø Identification of 83 novel alpha-mannosidosis-assoociated sequence variants: Functional analysis of MAB2B1 missense mutations. Human Mutation 2012; 33(3):511-20

Beck M, Olsen KJ, Wraith JE, Zeman J, Michalski JC, Saftig P, Fogh P, Malm D Natural history of alpha mannosidosis; a longitudinal story Orphanet J Rare Dis 2013 Jun 20;8:88. Doi:10.1186/1750-1172-8-88.

Malm D, Stensland HMFR, Edvardsen Ø, Nilssen Ø The Natural Course and complications of alpha-mannosidosis - A retrospective and descriptive study J Inher Metab Dis 2014 37:79-82

Stensland HMFR, Frantzen M, Kuokkanen E, Buvang EK, Klenow HB, Heikinheimo P, Malm D, Nilssen Ø Amamutdb.no: A Relational Database for MAN2B1 Allelic Variants that Compiles Genotypes, Clinical Phenotypes, and Biochemical and Structural Data of Mutant MAN2B1 in Alpha-mannosidosis Human Mutation 2015; 36: 581-586

ABSTRACTS

Malm D, Jenssen TG, Vonen B. & Burhol PG. Indometacin increases basal and arginine stimulated plasma glucose and decreases plasma levels of insulin, somatostatin and secretin in man. 20th Scand. Conf. on Gastroenterology, Trondheim 1987, Norway.

Florholmen J, Malm D, Vonen B & Burhol PG. CCK-induced phosphoinositol changes in isolated rat pancreatic islets. Norsk Gastroenterologisk årsmøte, Gol 1988.

Florholmen J, Malm D, Vonen B & Burhol PG. Cholecystokinin-induced accumulation of inositol tris- and tetrakisphosphates in isolated pancreatic islets. Scandinavian Society for the Study of Diabetes, Bergen 1988.

Florholmen J, Malm D, Vonen B, Burhol PG. The effect of glucose and cholecystokinin in the hydrolysis of the phosphoinositides in isolated pancreatic islets. XIII International Congress of Gastroenterology, Rome 1988

Malm D, Florholmen J, Vonen B, Burhol PG. Somatostatin inhibition of phospholipase C activity in isolated rat pancreatic islets. Scandinavian Society for the Study of Diabetes, Umeå 1989. Acta Endocrinol 1989, 120, suppl. 2, 25

Malm D, Vonen B, Burhol PG, Florholmen J. Somatostatin inhibition of insulin secretion. A study on intracellular mechanisms.

European Association for the Study of Diabetes, Lisboa 1989. Diabetologia 1989, 32, 514

Malm D: Cholecystokinin og somatostatin som regulatorer av insulinsekresjonen fra isolerte Langerhanske øyer. Lysebu 1990

Malm D, Florholmen J, Vonen B & Burhol PG. Interactions of the insulin secretory effect of cholecystokinin with somatostatin, atropine and verapamil. Scandinavian Society for the Study of Diabetes, Odense 1990. Acta Endocrinol 1990, 122, suppl. 3, 24.

Malm D, Vonen B, Burhol PG, Florholmen J. Dissotiation between glucose- and cholecystokinin-induced phospholipase C activition and insulin release during inhibition of isolated rat pancretic islets. Scandinavian Society for the Study of Diabetes, Helsinki 1991. Acta Endocrinol 1991, 124, suppl. 3, 24

Giæver A, Bertinussen A, Malm D, Haukland H, Vonen B, Florholmen J. Regulation of phosphoinositide metabolism by GTP-binding proteins in a poloma BK virus transformed pancreatic islets cell line. VIIth International Symposium on Cellular Endocrinology, New York 1991.

Giæver A, Malm D, Haukland H, Bertinussen A, Vonen B, Florholmen J. Phosphoinositide metabolism in a BK virus transformed cell line. XIth Biennial Meeting of the European Association for Cancer Research, Genoa 1991

Malm D, Giæver A, Vonen B, Florholmen J. The insulinotrophic effect of fructose is not explained by a activation og phospholipase C in pancreatic islets. Scandinavian Society for the Study of Diabetes, Stockholm 1993. Acta Endocrinol 1993, 126, suppl. 3, 25

Andersen K, Malm D. The use of ultrasound with sonography in the diagnosis of portal vein thrombosis (Norw.). The Norwegian Society for Ultrasound-diagnostics, Geilo 1993.

Malm D, Lindskog S, Florholmen J, Ahrén B. Dual effect of galanin on the hydrolysis of inositol phosphates in rat pancreatic islets. European Assosiation for the Study of Diabetes, Düsseldorf 1994. Diabetologia 1994.

Malm D. Medical treatment of peptic ulcer in Norway. Joint meeting of North-Norwegian Society og Gastroenterology and Arkhangelsk Region Society of Gastroenterologists, Archangelsk 1994.

Berg T, Malm D, Nilssen Ø, Tranebjærg L, Tollersrud OK. cDNA cloning and sequencing of feline and bovine lysosomal alpha-mannosidase: An important step in gene therapy studies of the cat model of human alpha-mannosidosis. Norsk Biokjemisk Vintermøte, Geilo 1995

Olafsson S, Malm D, Olafsson T. Efficacy and side effects of bismuth-based triple therapy and dual therapy with omeprazole and amoxicillin in eradication of Helicobacter pylorii in routine hospital practice. 28. Scand. Conf. on Gastroenterology Uppsala 1995

Tollersrud OK, Berg T, Riise HMF, Hansen G, Evjen G, Malm D, Tranebjærg L, Nilssen Ø. Structure/function studies and genotype/phenotype relationships of lysosomal -mannosidase. European Molecular Biology Laboratory, Tromsø 1995

Malm D, Halvorsen D, Tranebjærg L, Sjursen H. Characterization of the immunodeficiancy in alpha-mannosidosis. 10th EASGLD Workshop, Cambridge 1995

Riise HMF, Evjen G, Hansen GM, Malm D, Tollersrud OK. Purification and characterization of lysosomal alpha-mannosidase from seven mammals and two arctic fishes. 10th EASGLD Workshop, Cambridge 1995

Tollersrud OK, Berg T, Riise HMF, Hansen GM, Evjen G, Malm D, Tranebjærg L, Nilssen Ø. Purification and cDNA sequencing of bovine and human lysosomal alpha-mannosidase. Characterization of a missense mutation that causes alpha-mannosidasis. 10th EASGLD Workshop, Cambridge 1995

Malm D, Olafsson S. The value of symptom status as a predictor of eradication after treatment of Helicobacter pylori. UEGWD Berlin 1995

Nilssen Ø, Berg T, Ruberthiran U, Hansen GM, Riise HMF, Malm D, Tranebjærg L. Alpha-mannosidosis: Functional cloning of the alpha-mannosidase gene and identification of a mutant in affected siblings. Am Soc Hum Gen Minneapolis Am J Hum Genet 1995, 57, 4.

Riise HMF, Berg T, Hansen GM, Tollersrud OK, Malm D, Tranebjærg L, Nilssen Ø. Spectrum of mutations in human alpha-mannosidosis. European Society of Human Genetics, Genova, 1997

Berg T, Tollersrud OK, Malm D, Evjen G, Nilssen Ø. Biochemical and genetic characterization of normal and mutant lysosomal alpha-mannosidase from cattle and cats. European Society of Human Genetics, Genova, 1997

Hansen GM, Riise HMF, Berg T, Malm D, Michaelakakis H, Neon P, Barlsocas C, Tollersrud OK, Nilssen Ø. The genetic, biochemical, and clinical characteristics of a Greek patient with alpha-mannosidis. 7th Congress of Inborn Errors of Metabolism, Vienna 1997

Riise HMF, Berg T, Hansen GM, Tollersrud OK, Malm D, Tranebjærg L, Nilssen Ø. Spectrum of mutations in human alpha-mannosidosis. 7th Congress of Inborn Errors of Metabolism, Vienna 1997

Berg T, Tollersrud OK, Malm D, Evjen G, Nilssen Ø. Biochemical and genetic characterization of normal and mutant lysosomal alpha-mannosidase 7th Congress of Inborn Errors of Metabolism, Vienna 1997

Malm D, Riise HMF, Berg T, Gitzelmann R, Bosshard NU, Beck M, Tollersrud OK, Nilssen Ø. Splice-site mutations in human alpha-mannosidosis. 7th Congress of Inborn Errors of Metabolism, Vienna 1997

Tollersrud OK, Riise HMF, Hansen GM, Malm D, Tranebjærg L, Nilssen Ø. Biochemical, genetic and clinical characterization of alpha-mannosidosis. Norsk Biokjemisk Vintermøte Tromsø 1999

Erik R. Traasdahl , Johan Sundsfjord og Dag Malm . 75SeHCAT testen ved gallesyremalabsorpsjon: Utførelse og praktisk betydning. Norsk Selskap for Nukleærmedisin (Norwegian Society of Nuclear Medicine) Bolkesjø Hotell 2000

Azathioprin ved IBD. AZ Academy, Porto 2000.

Riise Stensland H.M.F., Klenow H., Malm D., Tollersrud O.K., and Nilssen Ø. Novel mutations and haplotypeanalysis in alpha-mannosidosis. The American Society of Human Genetics, 51th Annual Meeting, October 12-16, 2001, San Diego, USA. American Journal of Human Genetics, 69, no 4, : 631, #2811,2001.

Riise Stensland H.M.F., Klenow H., Malm D., Tollersrud O.K., and Nilssen Ø. Novel mutations and haplotypeanalysis in alpha-mannosidosis. Strategies for Therapy of MPS and Related Disorders, Los Angeles, CA, USA, June 21-24, 2001.

Malm D, Linaker O Psychiatric disturbances in Alpha-mannosidosis. 3rd Scientific Lysosomal Storage Disorders Congress, Paris, June 20-23, 2002

Malm D, Lindahl S, Sundby J, Mellgren SI, Riise HM, Glomstein A Bone Marrow Transplant in Alpha-Mannosidosis –Effect on the metabolic myopathy 3rd Scientific Lysosomal Storage Disorders Congress, Paris, June 20-23, 2002

Malm D Induction of Autoimmune Antibodies in Alpha-Mannosidosis –A Possible Important Pathophysiological Mechanism? 14th ESGLD Workshop, Podebrady 18-21, 2003

Klenow H, Riise HMF, Malm D, Tollersrud OK, Nilssen Ø Spectrum of Mutations and Haplotype Analysis in Alpha-Mannosidosis 14th ESGLD Workshop, Podebrady 18-21, 2003

Malm D Living with Alpha-Mannosidosis 1th World Congress on Glycoproteinosis, Washington April 18-21, 2004

Malm D, D. S. Halvorsen, O.P. Rekvik, J.P. Zanetta* Immunodeficiency and autoimmunity in Alpha-Mannosidosis. 7th International meeting on MPS, Mainz 2004

D Malm, HMFR Stensland, Ø Nilssen, Ø Edvardsen, University of Tromsoe, Norway The natural course of Alpha-Mannosidosis 15th ESGLD Workshop, Oslo, Sept 13-15, 2005

D Malm The Natural Course and Complications of Alpha-Mannosidosis. 2nd meeting on glycoproteinosis, Ann Arbor 2007

M Myranek, M Albert, JJ Boelens, JS Kuehl, A Glomstein, D Malm, T Lücke, KW Sykora Ergebnisse der allogenen Stammzelltransplantation bei Patienten mit Alpha-Mannosidose. Päd-AG-KBT an der Medizinische Hochschule Hannover 2009

Chapters in books: ”Bile acids: Absorption, malabsorption and diaré.” GLAXO-supported symposium Oslo 1997

”Prologue” First chapter in ”Lysosomal Disorders of the brain” by FM Platt and SU Walkley Oxford University Press, 2004 ISBN 0-19-850878-6

”Alfa-mannosidose” NEL (Norwegian Elektronic Medical Handbook) 2006 www.legehandboka.no.

”Beta-mannosidose” NEL (Norwegian Elektronic Medical Handbook) 2006 www.legehandboka.no.

“Glycoproteinosis” 14th Chapter in “Lysosomal Storage Disorders” by A Metha and B Winchester

Wiley-Blackwell 2012

Initiated medical homepages About biochemical, genetical and medical aspects of Alpha-Mannosidosis: http://www.mannosidosis.org

Curriculum vitae

Even Holt f 31.01.63.

Gift, tre barn 17.21,25 år

Bosatt Haslum Bærum

Utdannelse:

Sivil ingeniør NTH, Trondheim Avdeling for elektroteknikk og datateknikk 1986

Cand.med Universitetet i Tromsø 1991

Dr.med. Universitet i Oslo, Ullevål sykehus 1999 «Excitation-Contraction Coupling in Failing and Normal Cadiomyocytes»

Godkjent spesialist indremedisin/kardiologi 2007

Certified Electrophysiology Specialist (CEPS) 2009 Heart Ryhyhm Society USA

Arbeidserfaring: Turnustjeneste Larvik sykehus/Tranøy kommune 1991/1992 Militærlege Infanteriregiment II, Evjemoen 1993 Stipendiat/post.doc Ullevål Sykehus 1994-1998 Ass.lege/konst overlege Bærums sykheus 1999-2002 Medisinsk direktør Care4You 2002/03 Konst. overlege Bærum sykehus 2003-2004 Ass.lege Rikshospitalet hjertemedisinsk avdeling 2004-2007 Overlege/seksjonsoverlege hjertemedisinsk seksjon 2007-2012 Avtalespesialist HSØ Kardiologi/indremedisin 2011-

Diverse konsulentoppdrag medisinsk/teknisk industri Medforfatter på to kriminalromer (se under publikasjoner)

PUBLIKASJONER I INTERNASJONALE TIDSKRIFTER

Effect of thalidomide on cardiac remodeling in chronic heart failure: results of a double-blind, placebo-controlled study. Gullestad L, Ueland T, Fjeld JG, Holt E, Gundersen T, Breivik K, Følling M, Hodt A, Skårdal R, Kjekshus J, Andreassen A, Kjekshus E, Wergeland R, Yndestad A, Frøland SS, Semb AG, Aukrust P. Circulation. 2005 Nov 29;112(22):3408-14. Epub 2005 Nov 21.

Analysis of pravastatin to prevent recurrence of atrial fibrillation after electrical cardioversion. Tveit A, Grundtvig M, Gundersen T, Vanberg P, Semb AG, Holt E, Gullestad L. Am J Cardiol. 2004 Mar 15;93(6):780-2.

Effect of thalidomide in patients with chronic heart failure. Gullestad L, Semb AG, Holt E, Skårdal R, Ueland T, Yndestad A, Frøland SS, Aukrust P. Am Heart J. 2002 Nov;144(5):847-50.

Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity. Sande JB, Sjaastad I, Hoen IB, Bøkenes J, Tønnessen T, Holt E, Lunde PK, Christensen G. Cardiovasc Res. 2002 Feb 1;53(2):382-91.

Altered E-C coupling in rat ventricular myocytes from failing hearts 6 wk after MI. Wasserstrom JA, Holt E, Sjaastad I, Lunde PK, Odegaard A, Sejersted OM. Am J Physiol Heart Circ Physiol. 2000 Aug;279(2):H798-807. PMID:

Thyroid hormone control of contraction and the Ca(2+)- ATPase/phospholamban complex in adult rat ventricular myocytes. Holt E, Sjaastad I, Lunde PK, Christensen G, Sejersted OM. J Mol Cell Cardiol. 1999 Mar;31(3):645-56.

Mechanisms of cardiomyocyte dysfunction in heart failure following myocardial infarction in rats. Holt E, Tønnessen T, Lunde PK, Semb SO, Wasserstrom JA, Sejersted OM, Christensen G. J Mol Cell Cardiol. 1998 Aug;30(8):1581-93.

Reduced myocardial Na+, K(+)-pump capacity in congestive heart failure following myocardial infarction in rats. Semb SO, Lunde PK, Holt E, Tønnessen T, Christensen G, Sejersted OM. J Mol Cell Cardiol. 1998 Jul;30(7):1311-28.

Electrical stimulation of adult rat cardiomyocytes in culture improves contractile properties and is associated with altered calcium handling. Holt E, Lunde PK, Sejersted OM, Christensen G. Basic Res Cardiol. 1997 Oct;92(5):289-98.

Transient Ca2+ overload alters Ca2+ handling in rat cardiomyocytes: effects on shortening and relaxation. Holt E, Christensen G. Am J Physiol. 1997 Aug;273(2 Pt 2):H573-82.

ANDRE PULBLIKASJONER

UTGITT TO KRIMINALROMANER MED ANNE HOLT

«Sudden Death» Anne Holt og Even Holt Utgitt: 2014 Forlag: Vigmostad Bjørke

«Flimmer» Anne Holt og Even Holt Utgitt 2010 Forlag:Piratfolaget