Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Deslanoside Catalog Number : T8183 CAS Number : 17598-65-1 Molecular Formula : C47H74O19 Molecular Weight : 943.10

Description: Deslanoside is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

DMSO 95mg/mL (100.73 mM), Need ultrasonic Solubility ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Receptor (IC50) Na+/K+-ATPase

In vitro Activity Deslanoside increases forearm blood flow and cardiac index and decreased heart rate concomitant with a marked decrease in skeletal muscle sympathetic nerve activity [1]. Deslanoside is a metabolite of Lanatoside C [3].

Reference 1. Hauptman PJ, et al. Digitalis. Circulation. 1999 Mar 9;99(9):1265-70. 2. Wang L, et al. Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China. Sci Rep. 2017 Oct 23;7(1):13819. 4. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

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