December 30, 2014 u vol. 111 u no. 52 u 18401–18800

Cover image: Pictured are Konik horses, a semiferal breed, at a nature reserve in Oostvaar- dersplassen, Holland. Mikkel Schubert et al. sequenced the DNA from ancient horse bones and compared it to the genomes of five modern domesticated breeds and the only living wild horse species, Przewalski’s horse. Phylogenetic analysis revealed that domesticated breeds likely derived at least partially from the ancient populations. In addition, genes involved in muscle, limb, joint, and cardiac system development, and in social behavior, learning capa- bilities, fear response, and agreeableness were favored during domestication, indicating adaptations that may have resulted from human use and taming. See the article by Schubert et al. on pages E5661–E5669. Image courtesy of Ruben Smit (photographer). From the Cover

E5661 of horse domestication 18460 Dating mastodon extinction 18524 Ethnic diversity and price bubbles 18530 Gulf of Mexico hypoxic zone 18709 Plague bacteria and flea hosts

Contents REVIEWER ACKNOWLEDGMENT (ONLINE ONLY) E5724 Acknowledgment of Reviewers, 2014

THIS WEEK IN PNAS SCIENCE AND CULTURE—How science intersects with culture

18401 In This Issue 18403 Science and Culture: Q&A with Roger Malina Maggie McKee

LETTERS (ONLINE ONLY)

COMMENTARIES E5602 Incorrect representation of Barrier Canyon rock art site’s history and other factors invalidate reported dates Nancy Simon and Richard Reed 18405 The curious case of the Arctic mastodons Duane Froese E5604 Reply to Simon and Reed: Independent and converging See companion article on page 18460 results rule out historic disturbance and confirm age constraints for Barrier Canyon rock art 18407 Downsides of social capital Joel L. Pederson, Melissa S. Chapot, Steven R. Simms, Alejandro Portes Reza Sohbati, Tammy M. Rittenour, Andrew S. Murray, See companion article on page 18524 and Gary Cox 18409 Subtle genetic modifications transformed an E5605 Questionable evidence of natural warming of the enteropathogen into a flea-borne pathogen northwestern United States Elisabeth Carniel John T. Abatzoglou, David E. Rupp, and Philip W. Mote See companion article on page 18709 E5607 Reply to Abatzoglou et al.: Atmospheric controls on northwest United States air temperatures, 1948–2012 PNAS PLUS James A. Johnstone and Nathan J. Mantua

18411 Significance Statements Brief statements written by the authors about the significance of Free online through the PNAS open access option. their papers.

PNAS u December 30, 2014 u vol. 111 u no. 52 u iii–viii Downloaded by guest on October 1, 2021 EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES PERSPECTIVE 18460 American mastodon extirpation in the Arctic and Subarctic predates human colonization and terminal 18414 A taxonomy of prospection: Introducing an Pleistocene climate change organizational framework for future-oriented cognition Grant D. Zazula, Ross D. E. MacPhee, Jessica Z. Metcalfe, Karl K. Szpunar, R. Nathan Spreng, and Daniel L. Schacter Alberto V. Reyes, Fiona Brock, Patrick S. Druckenmiller, Pamela Groves, C. Richard Harington, Gregory W. L. Hodgins, Michael L. Kunz, Fred J. Longstaffe, Daniel H. Mann, H. Gregory McDonald, Shweta Nalawade-Chavan, INAUGURAL ARTICLES and John R. Southon See Commentary on page 18405

18422 van der Waals interactions at the nanoscale: The effects 18466 Occurrence of pristine aerosol environments on of nonlocality a polluted planet Yu Luo, Rongkuo Zhao, and John B. Pendry Douglas S. Hamilton, Lindsay A. Lee, Kirsty J. Pringle, Carly L. Reddington, Dominick V. Spracklen, 18428 Place cells in the hippocampus: Eleven maps for and Kenneth S. Carslaw eleven rooms Charlotte B. Alme, Chenglin Miao, Karel Jezek, 18472 Soil surface acidity plays a determining role in the Alessandro Treves, Edvard I. Moser, atmospheric-terrestrial exchange of nitrous acid and May-Britt Moser Melissa A. Donaldson, David L. Bish, and Jonathan D. Raff 18478 Laser altimetry reveals complex pattern of Greenland Ice Sheet dynamics Beata M. Csatho, Anton F. Schenk, Cornelis J. van der Veen, PHYSICAL SCIENCES Gregory Babonis, Kyle Duncan, Soroush Rezvanbehbahani, Michiel R. van den Broeke, Sebastian B. Simonsen, APPLIED PHYSICAL SCIENCES Sudhagar Nagarajan, and Jan H. van Angelen E5609 Absolute position total internal reflection microscopy with an optical tweezer ENGINEERING Lulu Liu, Alexander Woolf, Alejandro W. Rodriguez, 18484 Mechanical resilience and cementitious processes in and Federico Capasso Imperial Roman architectural mortar Marie D. Jackson, Eric N. Landis, Philip F. Brune, Massimo E5616 Links that speak: The global language network Vitti, Heng Chen, Qinfei Li, Martin Kunz, Hans-Rudolf and its association with global fame Wenk, Paulo J. M. Monteiro, and Anthony R. Ingraffea Shahar Ronen, Bruno Gonçalves, Kevin Z. Hu, Alessandro Vespignani, Steven Pinker, and César A. Hidalgo ENVIRONMENTAL SCIENCES E5623 Electrically pumped semiconductor laser with monolithic 18490 Life cycle air quality impacts of conventional and control of circular polarization alternative light-duty transportation in the Patrick Rauter, Jiao Lin, Patrice Genevet, Suraj P. Khanna, United States Mohammad Lachab, A. Giles Davies, Edmund H. Linfield, Christopher W. Tessum, Jason D. Hill, and Julian D. Marshall and Federico Capasso 18530 Cost-effective targeting of conservation investments to 18422 van der Waals interactions at the nanoscale: The effects reduce the northern Gulf of Mexico hypoxic zone of nonlocality Sergey S. Rabotyagov, Todd D. Campbell, Michael Yu Luo, Rongkuo Zhao, and John B. Pendry White, Jeffrey G. Arnold, Jay Atwood, M. Lee Norfleet, Catherine L. Kling, Philip W. Gassman, 18436 Existence of isostatic, maximally random jammed Adriana Valcu, Jeffrey Richardson, R. Eugene Turner, monodisperse hard-disk packings and Nancy N. Rabalais Steven Atkinson, Frank H. Stillinger, and Salvatore Torquato

PHYSICS CHEMISTRY 18496 Physical basis of spindle self-organization 18442 Structural dynamics inside a functionalized Jan Brugués and Daniel Needleman metal–organic framework probed by ultrafast 18501 Electronic evidence of an insulator–superconductor 2D IR spectroscopy crossover in single-layer FeSe/SrTiO films Jun Nishida, Amr Tamimi, Honghan Fei, Sonja Pullen, 3 Junfeng He, Xu Liu, Wenhao Zhang, Lin Zhao, Defa Liu, Sascha Ott, Seth M. Cohen, and Michael D. Fayer Shaolong He, Daixiang Mou, Fangsen Li, Chenjia Tang, Zhi 18448 In vivo anticancer activity of rhomboidal Li, Lili Wang, Yingying Peng, Yan Liu, Chaoyu Chen, Li Yu, Pt(II) metallacycles Guodong Liu, Xiaoli Dong, Jun Zhang, Chuangtian Chen, Ivan V. Grishagin, J. Bryant Pollock, Swati Kushal, Zuyan Xu, Xi Chen, Xucun Ma, Qikun Xue, and X. J. Zhou Timothy R. Cook, Peter J. Stang, and Bogdan Z. Olenyuk 18596 Thermotropic liquid crystals from biomacromolecules 18454 Quantum delocalization of protons in the Kai Liu, Dong Chen, Alessio Marcozzi, Lifei Zheng, hydrogen-bond network of an enzyme active site Juanjuan Su, Diego Pesce, Wojciech Zajaczkowski, Anke Lu Wang, Stephen D. Fried, Steven G. Boxer, Kolbe, Wojciech Pisula, Klaus Müllen, Noel A. Clark, and Thomas E. Markland and Andreas Herrmann

iv u www.pnas.org Downloaded by guest on October 1, 2021 STATISTICS 18513 Forests, fields, and the edge of sustainability at the 18507 Topological sensitivity analysis for systems biology ancient Maya city of Tikal Ann C. Babtie, Paul Kirk, and Michael P. H. Stumpf David L. Lentz, Nicholas P. Dunning, Vernon L. Scarborough, Kevin S. Magee, Kim M. Thompson, Eric Weaver, Christopher Carr, Richard E. Terry, Gerald Islebe, Kenneth B. Tankersley, Liwy Grazioso Sierra, SOCIAL SCIENCES John G. Jones, Palma Buttles, Fred Valdez, and Carmen E. Ramos Hernandez ANTHROPOLOGY 18513 Forests, fields, and the edge of sustainability at the ancient Maya city of Tikal BIOLOGICAL SCIENCES David L. Lentz, Nicholas P. Dunning, Vernon L. Scarborough, Kevin S. Magee, Kim M. Thompson, Eric APPLIED BIOLOGICAL SCIENCES Weaver, Christopher Carr, Richard E. Terry, Gerald Islebe, Kenneth B. Tankersley, Liwy Grazioso Sierra, E5633 Proteogenomic analysis and global discovery of John G. Jones, Palma Buttles, Fred Valdez, posttranslational modifications in prokaryotes and Carmen E. Ramos Hernandez Ming-kun Yang, Yao-hua Yang, Zhuo Chen, Jia Zhang, Yan Lin, Yan Wang, Qian Xiong, Tao Li, Feng Ge, Donald A. Bryant, and Jin-dong Zhao ECONOMIC SCIENCES 18519 Economic optimization of a global strategy to address the pandemic threat Jamison Pike, Tiffany Bogich, Sarah Elwood, David C. 18542 Stable, uncleaved HIV-1 envelope glycoprotein gp140 Finnoff, and Peter Daszak forms a tightly folded trimer with a native-like structure James M. Kovacs, Erik Noeldeke, Heather Jiwon Ha, 18524 Ethnic diversity deflates price bubbles Hanqin Peng, Sophia Rits-Volloch, Stephen C. Harrison, Sheen S. Levine, Evan P. Apfelbaum, Mark and Bing Chen Bernard, Valerie L. Bartelt, Edward J. Zajac, and David Stark 18548 Outward-facing conformers of LacY stabilized See Commentary on page 18407 by nanobodies Irina Smirnova, Vladimir Kasho, Xiaoxu Jiang, Els Pardon, Jan Steyaert, and H. Ronald Kaback ENVIRONMENTAL SCIENCES 18554 A divergent Pumilio repeat protein family for pre-rRNA 18530 Cost-effective targeting of conservation investments to processing and mRNA localization reduce the northern Gulf of Mexico hypoxic zone Chen Qiu, Kathleen L. McCann, Robert N. Wine, Susan J. Sergey S. Rabotyagov, Todd D. Campbell, Michael Baserga, and Traci M. Tanaka Hall White, Jeffrey G. Arnold, Jay Atwood, M. Lee Norfleet, Catherine L. Kling, Philip W. Gassman, 18560 Structure of a pantothenate transporter and implications Adriana Valcu, Jeffrey Richardson, R. Eugene Turner, for ECF module sharing and energy coupling of group II and Nancy N. Rabalais ECF transporters Minhua Zhang, Zhihao Bao, Qin Zhao, Hui Guo, Ke Xu, Chengcheng Wang, and Peng Zhang POLITICAL SCIENCES ERCC6/CSB 18536 The role of self-interest in elite bargaining 18566 Regulation of the Rhp26 chromatin remodeler Brad L. LeVeck, D. Alex Hughes, James H. Fowler, by a novel conserved leucine latch motif Emilie Hafner-Burton, and David G. Victor Lanfeng Wang, Oliver Limbo, Jia Fei, Lu Chen, Bong Kim, Jie Luo, Jenny Chong, Ronald C. Conaway, Joan W. Conaway, Jeff A. Ranish, James T. Kadonaga, Paul PSYCHOLOGICAL AND COGNITIVE SCIENCES Russell, and Dong Wang E5616 Links that speak: The global language network 18572 Identification of S-nitroso-CoA reductases that regulate and its association with global fame protein S-nitrosylation Shahar Ronen, Bruno Gonçalves, Kevin Z. Hu, Puneet Anand, Alfred Hausladen, Ya-Juan Wang, Alessandro Vespignani, Steven Pinker, Guo-Fang Zhang, Colin Stomberski, Henri Brunengraber, and César A. Hidalgo Douglas T. Hess, and Jonathan S. Stamler 18727 Reinstatement of distributed cortical oscillations 18578 Conformational activation of ADAMTS13 occurs with precise spatiotemporal dynamics during Kieron South, Brenda M. Luken, James T. B. successful memory retrieval Crawley, Rebecca Phillips, Mari Thomas, Richard F. Robert B. Yaffe, Matthew S. D. Kerr, Srikanth Collins, Louis Deforche, Karen Vanhoorelbeke, Damera, Sridevi V. Sarma, Sara K. Inati, and David A. Lane and Kareem A. Zaghloul 18584 Allosteric activation of ADAMTS13 by von Willebrand factor SUSTAINABILITY SCIENCE Joshua Muia, Jian Zhu, Garima Gupta, Sandra L. 18490 Life cycle air quality impacts of conventional and Haberichter, Kenneth D. Friedman, Hendrik B. Feys, alternative light-duty transportation in the Louis Deforche, Karen Vanhoorelbeke, Lisa A. United States Westfield, Robyn Roth, Niraj Harish Tolia, John E. Christopher W. Tessum, Jason D. Hill, and Julian D. Marshall Heuser, and J. Evan Sadler

PNAS u December 30, 2014 u vol. 111 u no. 52 u v Downloaded by guest on October 1, 2021 18590 A small-molecule mimic of a peptide docking motif 18637 Mice deficient in Rbm38, a target of the p53 family, inhibits the protein kinase PDK1 are susceptible to accelerated aging and T. Justin Rettenmaier, Jack D. Sadowsky, Nathan D. spontaneous tumors Thomsen, Steven C. Chen, Allison K. Doak, Michelle R. Jin Zhang, Enshun Xu, Cong Ren, Wensheng Yan, Min Arkin, and James A. Wells Zhang, Mingyi Chen, Robert D. Cardiff, Denise M. Imai, Erik Wisner, and Xinbin Chen

BIOPHYSICS AND COMPUTATIONAL BIOLOGY DEVELOPMENTAL BIOLOGY E5643 Bifurcation analysis of single-cell gene expression E5651 Hedgehog-induced phosphorylation by CK1 sustains the data reveals epigenetic landscape activity of Ci/Gli activator Eugenio Marco, Robert L. Karp, Guoji Guo, Paul Qing Shi, Shuang Li, Shuangxi Li, Alice Jiang, Yongbin Chen, Robson, Adam H. Hart, Lorenzo Trippa, and Jin Jiang and Guo-Cheng Yuan 18643 PTEN signaling through RAF1 proto-oncogene 18496 Physical basis of spindle self-organization serine/threonine kinase (RAF1)/ERK in the epididymis Jan Brugués and Daniel Needleman is essential for male fertility 18507 Topological sensitivity analysis for systems biology Bingfang Xu, Angela M. Washington, and Barry T. Hinton Ann C. Babtie, Paul Kirk, and Michael P. H. Stumpf

18596 Thermotropic liquid crystals from biomacromolecules ECOLOGY Kai Liu, Dong Chen, Alessio Marcozzi, Lifei Zheng, 18649 Nonrandom, diversifying processes are Juanjuan Su, Diego Pesce, Wojciech Zajaczkowski, Anke disproportionately strong in the smallest size classes Kolbe, Wojciech Pisula, Klaus Müllen, Noel A. Clark, of a tropical forest and Andreas Herrmann Peter T. Green, Kyle E. Harms, and Joseph H. Connell 18601 In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability EVOLUTION Vikas K. Sharma, Thomas W. Patapoff, Bruce Kabakoff, E5661 Prehistoric genomes reveal the genetic foundation and Satyan Pai, Eric Hilario, Boyan Zhang, Charlene Li, cost of horse domestication Oleg Borisov, Robert F. Kelley, Ilya Chorny, Joe Z. Mikkel Schubert, Hákon Jónsson, Dan Chang, Clio Zhou, Ken A. Dill, and Trevor E. Swartz Der Sarkissian, Luca Ermini, Aurélien Ginolhac, Anders 18607 Detergent-free isolation, characterization, and functional Albrechtsen, Isabelle Dupanloup, Adrien Foucal, Bent reconstitution of a tetrameric K+ channel: The power Petersen, Matteo Fumagalli, Maanasa Raghavan, Andaine of native nanodiscs Seguin-Orlando, Thorfinn S. Korneliussen, Amhed M. V. Jonas M. Dörr, Martijn C. Koorengevel, Marre Schäfer, Velazquez, Jesper Stenderup, Cindi A. Hoover, Carl-Johan Alexander V. Prokofyev, Stefan Scheidelaar, Elwin A. W. Rubin, Ahmed H. Alfarhan, Saleh A. Alquraishi, Khaled A. S. van der Cruijsen, Timothy R. Dafforn, Marc Baldus, Al-Rasheid, David E. MacHugh, Ted Kalbfleisch, James N. and J. Antoinette Killian MacLeod, Edward M. Rubin, Thomas Sicheritz-Ponten, Leif Andersson, Michael Hofreiter, Tomas Marques-Bonet, 18613 Structural basis for the auxin-induced transcriptional M. Thomas P. Gilbert, Rasmus Nielsen, Laurent Excoffier, regulation by Aux/IAA17 Eske Willerslev, Beth Shapiro, and Ludovic Orlando Mookyoung Han, Yangshin Park, Iktae Kim, Eun-Hee Kim, Tae-Kyung Yu, Sangkee Rhee, and Jeong-Yong Suh 18655 Speciation with gene flow in equids despite extensive chromosomal plasticity 18619 TDP-43 N terminus encodes a novel ubiquitin-like fold Hákon Jónsson, Mikkel Schubert, Andaine Seguin-Orlando, and its unfolded form in equilibrium that can be shifted Aurélien Ginolhac, Lillian Petersen, Matteo Fumagalli, by binding to ssDNA Anders Albrechtsen, Bent Petersen, Thorfinn S. Haina Qin, Liang-Zhong Lim, Yuanyuan Wei, Korneliussen, Julia T. Vilstrup, Teri Lear, Jennifer Leigh and Jianxing Song Myka, Judith Lundquist, Donald C. Miller, Ahmed H. Alfarhan, Saleh A. Alquraishi, Khaled A. S. Al-Rasheid, Julia 18625 Structural basis of HIV-1 capsid recognition by PF74 Stagegaard, Günter Strauss, Mads Frost Bertelsen, Thomas and CPSF6 Sicheritz-Ponten, Douglas F. Antczak, Ernest Bailey, Rasmus Akash Bhattacharya, Steven L. Alam, Thomas Fricke, Nielsen, Eske Willerslev, and Ludovic Orlando Kaneil Zadrozny, Jaroslaw Sedzicki, Alexander B. Taylor, Borries Demeler, Owen Pornillos, Barbie K. Ganser-Pornillos, Felipe Diaz-Griffero, Dmitri N. GENETICS Ivanov, and Mark Yeager E5670 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila Youheng Wei, Brad Reveal, John Reich, Willem J. Laursen, Stefania Senger, Tanveer Akbar, Takako Iida-Jones, Weili E5609 Absolute position total internal reflection microscopy Cai, Michal Jarnik, and Mary A. Lilly with an optical tweezer 18661 Genetic modifiers of EGFR dependence in non-small Lulu Liu, Alexander Woolf, Alejandro W. Rodriguez, cell lung cancer and Federico Capasso Tanaz Sharifnia, Victor Rusu, Federica Piccioni, Mukta Bagul, 18631 Treacher Collins syndrome TCOF1 protein cooperates Marcin Imielinski, Andrew D. Cherniack, Chandra Sekhar with NBS1 in the DNA damage response Pedamallu, Bang Wong, Frederick H. Wilson, Levi A. Alberto Ciccia, Jen-Wei Huang, Lior Izhar, Mathew E. Sowa, Garraway, David Altshuler, Todd R. Golub, David E. J. Wade Harper, and Stephen J. Elledge Root, Aravind Subramanian, and Matthew Meyerson

vi u www.pnas.org Downloaded by guest on October 1, 2021 IMMUNOLOGY AND INFLAMMATION E5678 Essential role for autophagy during invariant NKT E5706 Estrogen-related receptor α is required for efficient cell development human cytomegalovirus replication Mariolina Salio, Daniel J. Puleston, Till S. M. Mathan, Jesse Hwang, John G. Purdy, Kai Wu, Joshua D. Rabinowitz, Dawn Shepherd, Amanda J. Stranks, Eleni Adamopoulou, and Thomas Shenk Natacha Veerapen, Gurdyal S. Besra, Georg A. Hollander, 18703 pH modulates the activity and synergism of the airway Anna Katharina Simon, and Vincenzo Cerundolo surface liquid antimicrobials β-defensin-3 and LL-37 E5688 Licensed human natural killer cells aid dendritic cell Mahmoud H. Abou Alaiwa, Leah R. Reznikov, Nicholas D. maturation via TNFSF14/LIGHT Gansemer, Kelsey A. Sheets, Alexander R. Horswill, Tim D. Holmes, Erica B. Wilson, Emma V. I. Black, David A. Stoltz, Joseph Zabner, and Michael J. Welsh Andrew V. Benest, Candida Vaz, Betty Tan, Vivek M. 18709 Silencing urease: A key evolutionary step that facilitated Tanavde, and Graham P. Cook the adaptation of Yersinia pestis to the flea-borne 18667 Epigenetic targeting of activation-induced transmission route cytidine deaminase Iman Chouikha and B. Joseph Hinnebusch Qiao Wang, Thiago Oliveira, Mila Jankovic, Israel T. Silva, See Commentary on page 18409 Ofir Hakim, Kaihui Yao, Anna Gazumyan, Christian T. 18715 Revealing bacterial targets of growth inhibitors Mayer, Rushad Pavri, Rafael Casellas, Michel C. encoded by bacteriophage T7 Nussenzweig, and Davide F. Robbiani Shahar Molshanski-Mor, Ido Yosef, Ruth Kiro, Rotem 18673 RORγt-specific transcriptional interactomic inhibition Edgar, Miriam Manor, Michael Gershovits, Mia Laserson, suppresses autoimmunity associated with TH17 cells Tal Pupko, and Udi Qimron Tae-Yoon Park, Sung-Dong Park, Jen-Young Cho, Jae-Seung 18721 Wolbachia small noncoding RNAs and their role Moon, Na-Yeon Kim, Kyungsoo Park, Rho Hyun Seong, in cross-kingdom communications Sang-Won Lee, Tomohiro Morio, Alfred L. M. Bothwell, Jaime G. Mayoral, Mazhar Hussain, D. Albert and Sang-Kyou Lee Joubert, Iñaki Iturbe-Ormaetxe, Scott L. O’Neill, and Sassan Asgari MEDICAL SCIENCES E5697 GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates NEUROSCIENCE placental 5-HT uptake E5716 STAT3 promotes survival of mutant photoreceptors in Yicong Li, Coedy Hadden, Preeti Singh, Charles P. Mercado, inherited photoreceptor degeneration models Pamela Murphy, Nafisa K. Dajani, Curtis L. Lowery, Ke Jiang, Katherine L. Wright, Ping Zhu, Michael J. Drucilla J. Roberts, Luc Maroteaux, and Fusun Kilic Szego, Alexa N. Bramall, William W. Hauswirth, Qiuhong Li, Sean E. Egan, and Roderick R. McInnes 18519 Economic optimization of a global strategy to address the pandemic threat 18428 Place cells in the hippocampus: Eleven maps for Jamison Pike, Tiffany Bogich, Sarah Elwood, David C. eleven rooms Finnoff, and Peter Daszak Charlotte B. Alme, Chenglin Miao, Karel Jezek, Alessandro Treves, Edvard I. Moser, 18679 Expression and prognostic impact of lncRNAs in acute and May-Britt Moser myeloid leukemia Ramiro Garzon, Stefano Volinia, Dimitrios Papaioannou, 18727 Reinstatement of distributed cortical oscillations Deedra Nicolet, Jessica Kohlschmidt, Pearlly S. Yan, occurs with precise spatiotemporal dynamics during Krzysztof Mrózek, Donna Bucci, Andrew J. Carroll, Maria R. successful memory retrieval Baer, Meir Wetzler, Thomas H. Carter, Bayard L. Powell, Robert B. Yaffe, Matthew S. D. Kerr, Srikanth Jonathan E. Kolitz, Joseph O. Moore, Ann-Kathrin Eisfeld, Damera, Sridevi V. Sarma, Sara K. Inati, James S. Blachly, William Blum, Michael A. Caligiuri, and Kareem A. Zaghloul Richard M. Stone, Guido Marcucci, Carlo M. Croce, 18733 Glutamatergic regulation prevents hippocampal- John C. Byrd, and Clara D. Bloomfield dependent age-related cognitive decline through 18685 Nonredundant protective properties of FPR2/ALX in dendritic spine clustering polymicrobial murine sepsis Ana C. Pereira, Hilary K. Lambert, Yael S. Grossman, Thomas Gobbetti, Sina M. Coldewey, Jianmin Chen, Simon Dani Dumitriu, Rachel Waldman, Sophia K. Jannetty, McArthur, Pauline le Faouder, Nicolas Cenac, Roderick J. Katina Calakos, William G. Janssen, Bruce S. McEwen, Flower, Christoph Thiemermann, and Mauro Perretti and John H. Morrison 18691 TSPAN12 is a critical factor for cancer–fibroblast cell 18739 Cellular resolution optical access to brain regions in contact-mediated cancer invasion fissures: Imaging medial prefrontal cortex and grid Ryo Otomo, Chihiro Otsubo, Yuko Matsushima-Hibiya, cells in entorhinal cortex Makoto Miyazaki, Fumio Tashiro, Hitoshi Ichikawa, Ryan J. Low, Yi Gu, and David W. Tank Takashi Kohno, Takahiro Ochiya, Jun Yokota, Hitoshi 18745 Large-scale topology and the default mode network Nakagama, Yoichi Taya, and Masato Enari in the mouse connectome 18697 A long noncoding RNA connects c-Myc to James M. Stafford, Benjamin R. Jarrett, Oscar tumor metabolism Miranda-Dominguez, Brian D. Mills, Nicholas Cain, Chiu-Lien Hung, Ling-Yu Wang, Yen-Ling Yu, Stefan Mihalas, Garet P. Lahvis, K. Matthew Lattal, Hong-Wu Chen, Shiv Srivastava, Gyorgy Petrovics, Suzanne H. Mitchell, Stephen V. David, John D. Fryer, and Hsing-Jien Kung Joel T. Nigg, and Damien A. Fair

PNAS u December 30, 2014 u vol. 111 u no. 52 u vii Downloaded by guest on October 1, 2021 18751 Identification of a pheromone that increases anxiety PSYCHOLOGICAL AND COGNITIVE SCIENCES in rats 18524 Ethnic diversity deflates price bubbles Hideaki Inagaki, Yasushi Kiyokawa, Shigeyuki Tamogami, Sheen S. Levine, Evan P. Apfelbaum, Mark Hidenori Watanabe, Yukari Takeuchi, and Yuji Mori Bernard, Valerie L. Bartelt, Edward J. Zajac, and David Stark PHYSIOLOGY See Commentary on page 18407 18757 Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase Brian P. Johnson, Jacqueline A. Walisser, Yan Liu, Anna L. CORRECTIONS Shen, Erin L. McDearmon, Susan M. Moran, Brian E. McIntosh, Aaron L. Vollrath, Andrew C. Schook, APPLIED PHYSICAL SCIENCES Joseph S. Takahashi, and Christopher A. Bradfield 18799 Motionless phase stepping in X-ray phase contrast 18763 Myosin binding protein-C activates thin filaments and imaging with a compact source inhibits thick filaments in heart muscle cells Houxun Miao, Lei Chen, Eric E. Bennett, Nick M. Thomas Kampourakis, Ziqian Yan, Mathias Gautel, Yin-Biao Adamo, Andrew A. Gomella, Alexa M. DeLuca, Ajay Sun, and Malcolm Irving Patel, Nicole Y. Morgan, and Han Wen

PLANT BIOLOGY NEUROSCIENCE 18769 Auxin depletion from leaf primordia contributes to 18799 Individual differences in the peripheral immune organ patterning system promote resilience versus susceptibility to Jiyan Qi, Ying Wang, Ting Yu, Alexandre Cunha, Binbin Wu, social stress Teva Vernoux, Elliot Meyerowitz, and Yuling Jiao Georgia E. Hodes, Madeline L. Pfau, Marylene Leboeuf, 18775 Maize SBP-box transcription factors unbranched2 Sam A. Golden, Daniel J. Christoffel, Dana Bregman, and unbranched3 affect yield traits by regulating Nicole Rebusi, Mitra Heshmati, Hossein Aleyasin, the rate of lateral primordia initiation Brandon L. Warren, Benoit Lebonté, Sarah Horn, George S. Chuck, Patrick J. Brown, Robert Meeley, Kyle A. Lapidus, Viktoria Stelzhammer, Erik H. F. and Sarah Hake Wong, Sabine Bahn, Vaishnav Krishnan, Carlos A. Bolaños-Guzman, James W. Murrough, Miriam 18781 Phytochrome controls alternative splicing to mediate Merad, and Scott J. Russo light responses in Arabidopsis Hiromasa Shikata, Kousuke Hanada, Tomokazu Ushijima, Moeko Nakashima, Yutaka Suzuki, and Tomonao Matsushita PHARMACOLOGY 18799 Targeting the minor pocket of C5aR for the rational 18787 Maternal temperature history activates Flowering Locus design of an oral allosteric inhibitor for inflammatory T in fruits to control progeny dormancy according to and neuropathic pain relief time of year Alessio Moriconi, Thiago M. Cunha, Guilherme R. Min Chen, Dana R. MacGregor, Anuja Dave, Hannah Souza, Alexandre H. Lopes, Fernando Q. Cunha, Victor L. Florance, Karen Moore, Konrad Paszkiewicz, Nicholas Carneiro, Larissa G. Pinto, Laura Brandolini, Andrea Smirnoff, Ian A. Graham, and Steven Penfield Aramini, Cinzia Bizzarri, Gianluca Bianchini, Andrea R. Beccari, Marco Fanton, Agostino Bruno, Gabriele POPULATION BIOLOGY Costantino, Riccardo Bertini, Emanuela Galliera, 18793 Correlated variation and population differentiation Massimo Locati, Sérgio H. Ferreira, Mauro M. Teixeira, in satellite DNA abundance among lines of and Marcello Allegretti Drosophila melanogaster Kevin H.-C. Wei, Jennifer K. Grenier, Daniel A. Barbash, and Andrew G. Clark ix Subscription Form

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