TIBOLONE 2.5MG TAB Class: Estrogen and Progestin

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TIBOLONE 2.5MG TAB Class: Estrogen and Progestin Combination(synthetic steroid hormone) Indications: Prevention of postmenopausal osteoporosis; symptomatic treatment of hot flushes and associated sweating resulting from menopause (surgical or natural); improvement of bone mineral density in patients with established postmenopausal osteoporosis Available dosage form in the hospital: TIBOLONE 2.5MG TAB Dosage: -Symptoms associated with menopause: Females: Oral: 2.5 mg once daily. Initiate ≥1 year after naturally occurring menopause, or immediately in women with surgical menopause or those being treated with gonadotropin releasing hormone (GnRH) analogues. Note: Use caution in women >60 years of age due to increased stroke risk -Switching from other hormone replacement therapy (HRT): If on sequential HRT, initiate tibolone 1 day after the completion of the current treatment cycle. If on continuous-combined HRT, may initiate tibolone therapy immediately. Note: A separate progestogen should not be added to tibolone. -Missed dose: If >12 hours has elapsed, skip dose and resume at next regularly scheduled time. -Osteoporosis prophylaxis in postmenopausal women (unlabeled use in some countries): Oral: 2.5 mg once daily (Bundred, 2012; Roux, 2002). Note: In women >60 years of age, an increased risk of stroke was reported when taking 1.25 mg daily (Cummings, 2008). Geriatric Refer to adult dosing. Use caution in women >60 years of age due to increased stroke risk. Renal Impairment: No dosage adjustment provided in manufacturer’s labeling; use with caution (may increase risk of fluid retention). Hepatic Impairment: Use is contraindicated in acute or chronic liver disease. Common side effect: Common side effects observed in clinical studies (occurring in 1-10% of the women using Livial) were: vaginal bleeding or spotting abdominal pain weight gain breast pain unnatural hair growth vaginal symptoms, such as discharge, itching, and Pregnancy Risk Factor: D (Adverse events have been observed in animal reproduction studies; use is contraindicated during pregnancy). .

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Research Publications by DISTINCTIONS Any Scientist of Pakistan in Last 10 Year and SERVICES  Secretary General, the Chemical Society of Pakistan
CV and List of Publications PROF. DR. MUHAMMAD IQBAL CHOUDHARY (Hilal-e-Imtiaz, Sitara-e-Imtiaz, Tamgha-ei-Imtiaz) International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research) University of Karachi, Karachi-75270 Pakistan Tel: (92-21) 34824924, 34824925 Fax: 34819018, 34819019 E-mail: [email protected] Web Page: www.iccs.edu Biodata and List of Publications Pag No. 2 MUHAMMAD IQBAL CHOUDHARY (Hilal-e-Imtiaz, Sitara-e-Imtiaz, Tamgha-e-Imtiaz) D-131, Phase II, D. O. H. S., Malir Cant., Karachi-75270, Pakistan Ph.: 92-21-4901110 MAILING INTERNATIONAL CENTER FOR CHEMICAL AND BIOLOGICAL SCIENCES ADDRESS (H. E. J. Research Institute of Chemistry Dr. Panjwani Center for Molecular Medicine and Drug Research) University of Karachi Karachi-74270, Pakistan Tel: (92-21) 34824924-5 Fax: (92-21) 34819018-9 Email: [email protected] Web: www.iccs.edu DATE OF BIRTH September 11, 1959 (Karachi, Pakistan) EDUCATION Doctor of Science (D.Sc.) (University of Karachi ) 2005 Ph.D. (Organic Chemistry) 1987 H. E. J. Research Institute of Chemistry University of Karachi, Karachi-75270, Pakistan Thesis Title: "The Isolation and Structural Studies on Some Medicinal Plants of Pakistan, Buxus papillosa, Catharanthus roseus, and Cissampelos pareira." M.Sc. (Organic Chemistry) 1983 University of Karachi, Karachi-75270, Pakistan B.Sc. (Chemistry, Biochemistry, Botany) 1980 University of Karachi, Karachi-75270, Pakistan AWARDS & Declared as the top most scientist (Number 1) among 1,650 HONORS scientists of Pakistan in all disciplines / fields of science and technology (year 2012) by the Pakistan Council for Science and Technology (Ministry of Science and Technology), Pakistan.
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St John's Institute of Dermatology
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< MOH Approved Drugs List >
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