Table S1: Mouse AKR vs DBA tumor gene list Probe set GB acc Symbol UGCluster 1425583_at BC010605 1425614_x_at M83244 H2-D1 Mm.33263 1427651_x_at X00246 H2-L /// H2-D1 Mm.33263 1419157_at AI428101 Sox4 Mm.240627 1422565_s_at NM_008688 1452544_x_at J00406 H2-D1 Mm.33263 AFFX-BioB-M_at 1425584_x_at BC010605 AFFX-r2-Ec-bioB-M_at 1426278_at AY090098 2310061N23Rik Mm.271275 1423411_at BI099836 BC013481 Mm.332406 1459725_s_at C86550 Dcpp Mm.287985 1419327_at NM_053181 AA415817 Mm.171484 AFFX-r2-Ec-bioB-3_at 1455869_at BG862223 1416770_at NM_021537 Stk25 Mm.28761 AFFX-r2-Ec-bioB-5_at 1418283_at NM_009903 Cldn4 Mm.7339 1424775_at BC018470 Oas1g Mm.14301 1428850_x_at AK004342 2410026K10Rik Mm.260878 1426633_s_at AW553424 D7Ertd760e 1427932_s_at BI076834 1200003I10Rik /// 1200015M12RikMm.332931 /// 1200016E24Rik 1449289_a_at BF715219 B2m Mm.163 AFFX-r2-Ec-bioC-3_at 1426632_at AW553424 D7Ertd760e 1448207_at BC010840 Lasp1 Mm.271967 1450017_at BG065754 Ccng1 Mm.2103 1451777_at BC013672 BC013672 Mm.33332 1420352_at NM_133731 Prss22 Mm.157351 1423747_a_at BC027196 Pdk1 Mm.34411 1454169_a_at AK017174 Epsti1 Mm.68134 1448793_a_at BC005679 Sdc4 Mm.3815 AFFX-r2-Ec-bioC-5_at 1425161_a_at BC005574 5730502D15Rik 1423158_at AK008566 Gnpnat1 Mm.233534 1453196_a_at BQ033138 Oasl2 Mm.228363 1449250_at NM_033573 Prcc Mm.35089 1452428_a_at AI099111 B2m Mm.163 1421024_at BB524140 Agpat1 Mm.8684 1450016_at BG065754 Ccng1 Mm.2103 1419043_a_at BM239828 AW111922 Mm.326506 1449262_s_at BB704337 Lin7c Mm.235300 1426975_at BG067859 4632413K17Rik Mm.295246 1426164_a_at AF479773 Usf1 Mm.8 1417461_at NM_007598 Cap1 Mm.8687 1424101_at BC027206 Hnrpl Mm.331189 1438758_at AU046270 1430575_a_at BB484264 Tpp2 Mm.234139 1459909_at BI249259 1451593_at BC018402 H2-Q1 Mm.214762 1422772_at NM_052993 C1galt1 Mm.102752 1450396_at NM_021465 Stag2 Mm.290422 1416986_a_at AB018194 Ptpns1 Mm.1682 1425521_at BC019726 Paip1 Mm.132584 1421014_a_at BC023398 Clybl Mm.34608 1456262_at BE446879 Rbm5 Mm.259197 1422179_at NM_008127 Gjb4 Mm.56906 1450576_a_at NM_013651 Sf3a2 Mm.262677 1418003_at NM_025427 1190002H23Rik Mm.29811 1427037_at BF227830 Eif4g1 Mm.260256 1452540_a_at M25487 Hist1h2bc /// Hist1h2beMm.314098 /// Hist1h2bp 1451683_x_at M34962 H2-L /// H2-D1 Mm.33263 1419042_at BM239828 AW111922 Mm.261140 1426713_s_at BM238943 Eprs Mm.154511 1416374_at AF242857 Ap3m1 Mm.300064 1436737_a_at BB737680 Sorbs1 Mm.210815 1451640_a_at BC008229 1500011J06Rik Mm.276341 1449145_a_at AB029929 Cav1 Mm.28278 1422102_a_at BC024319 Stat5b Mm.34064 1418280_at NM_011803 Copeb Mm.275036 1418191_at NM_011909 Usp18 Mm.326911 1434676_at BM118290 1419066_at NM_030244 Ier5l Mm.295464 1427471_at BF782863 Fbxl3a Mm.214746 1418527_a_at NM_010178 Fusip1 Mm.10229 1452294_at AK008111 2010005A06Rik Mm.36560 1448997_at AB013464 Pscd1 Mm.86413 1416101_a_at NM_015786 Hist1h1c Mm.193539 1419416_a_at NM_011244 Rarg Mm.1273 1419032_at AW556821 2610018G03Rik Mm.46254 1430514_a_at AK002762 2410026K10Rik Mm.260878 1417065_at NM_007913 1431213_a_at BG297038 1450006_at NM_019744 Ncoa4 Mm.275762 1422736_at NM_019930 Ranbp9 Mm.148781 1451931_x_at M69068 H2-L /// H2-D1 Mm.33263 1450170_x_at NM_010380 H2-L /// H2-D1 Mm.33263 1453556_x_at AK002762 2410026K10Rik Mm.260878 1451860_a_at AF220015 Trim30 Mm.295578 1436898_at BI738328 Sfpq Mm.257276 1449875_s_at NM_010395 H2-T10 Mm.87776 1425281_a_at AF201289 Dsip1 Mm.22216 1436320_at W45978 Mm.178550 1448309_at AF242857 Ap3m1 Mm.300064 1417229_at AF084459 Capn1 Mm.6221 1421491_a_at NM_029478 4930579A11Rik Mm.243797 1451564_at BC021340 1600029O10Rik Mm.244406 1426787_at AW744519 2310047I15Rik Mm.236878 1433674_a_at BQ177137 Rnu22 1427175_at BC004761 AI428936 Mm.227325 1418580_at BC024872 5830458K16Rik Mm.180157 1419816_s_at AI788755 1300002F13Rik Mm.249333 1418019_at NM_007754 Cpd Mm.276736 1451034_at BG094962 Zfp36l2 Mm.347400 1450033_a_at AW214029 Stat1 Mm.277406 1421025_at BB524140 Agpat1 Mm.8684 1422044_at AF074926 Ndst1 Mm.181862 1423748_at BC027196 Pdk1 Mm.34411 1452519_a_at X14678 AFFX-BioB-5_at 1420170_at C80049 Myh9 Mm.29677 1417133_at NM_008885 Pmp22 Mm.1237 1454106_a_at AK017941 Cxxc1 Mm.17537 1425028_a_at BC024358 Tpm2 Mm.646 1451908_a_at BC005766 Sec14l1 Mm.272312 1427276_at BI665568 Smc4l1 Mm.206841 1434380_at BM241271 Mm.254851 1448805_at NM_009480 Usf1 Mm.8 1438390_s_at AV105428 Pttg1 Mm.6856 1424518_at BC020489 1435137_s_at BB119177 1200015M12Rik 1418536_at M29881 H2-Q7 Mm.34421 1425336_x_at BC011306 H2-K1 Mm.196032 1425502_x_at BC003207 1452364_at BG066534 D11Ertd530e Mm.283410 1454699_at BG076140 Sesn1 Mm.276226 1417459_at NM_019910 Dcpp Mm.287985 1456398_at BB648848 1417613_at BF147705 Ier5 Mm.12246 1417084_at NM_010124 Eif4ebp2 Mm.259516 1417793_at NM_019440 AI481100 Mm.301384 1449199_at NM_013605 Muc1 Mm.16193 1427262_at L04961 Xist 1427746_x_at S70184 H2-K1 Mm.16771 1421322_a_at NM_008394 Isgf3g Mm.2032 1451501_a_at BC024375 Ghr Mm.3986 1416204_at BC019391 Gpd1 Mm.252391 1429040_at BE692399 2610005L07Rik Mm.157360 1425545_x_at M86502 H2-L 1420899_at AW542340 Rab18 Mm.132802 1460194_at NM_010726 Phyh Mm.27066 1455930_at BI651113 1426478_at AA124924 Rasa1 Mm.259653 1449740_s_at C79957 Dsg2 Mm.345891 1426051_a_at BC006628 Cenpb 1431008_at BG916808 0610037M15Rik Mm.221293 1431686_a_at AK013970 Gmfb Mm.87312 1420948_s_at BB825830 4833408C14Rik 1421789_s_at NM_007478 Arf3 Mm.221298 1450846_at AV144956 Bzw1 Mm.261831 1427387_a_at L04678 Itgb4 Mm.213873 1421009_at BB741897 2510004L01Rik Mm.24045 1418072_at NM_023422 1421754_at NM_133243 AY036118 1417141_at NM_018738 Igtp Mm.33902 1450034_at AW214029 Stat1 Mm.277406 1423754_at BC010291 Ifitm3 Mm.141021 1449025_at NM_010501 Mm.353948 1451018_at BF658789 Leprotl1 Mm.34212 1426324_at M33151 H2-L /// H2-D1 /// H2-K1Mm.196032 /// H2-Q2 /// H2-Bl 1451426_at AF316999 D11Lgp2e Mm.271830 1419927_s_at AW549708 Rabif Mm.198119 1452747_at BM944122 1110012E06Rik Mm.205625 1452254_at BB292990 Mtmr9 Mm.259107 1422141_s_at NM_033616 Csprs Mm.248553 1428106_at AK004841 1300001I01Rik Mm.214574 1449009_at NM_011579 Tgtp Mm.338891 1427319_at AI607603 A230046K03Rik Mm.278577 1424617_at BC008158 Ifi35 Mm.45558 1430999_a_at BM932452 Scoc Mm.219245 1423711_at BC018422 Ndufaf1 Mm.5390 1427882_at AK016368 4930588M11Rik Mm.278808 1417601_at NM_015811 Rgs1 Mm.103701 1431645_a_at AK013104 Gdi3 Mm.153226 1422962_a_at NM_010724 Psmb8 Mm.180191 1416732_at BB166592 Top2b Mm.130362 1421060_at AF312858 Mllt1 Mm.148748 1449029_at NM_021462 Mknk2 Mm.42126 1432004_a_at AK015410 Dnm2 Mm.39292 1416421_a_at BG796845 Ssb Mm.10508 1426888_at BI412952 Bat8 Mm.35345 1448117_at BB815530 Kitl Mm.45124 1416016_at AW048052 Tap1 Mm.207996 1436343_at BM502696 Chd4 Mm.333388 1450392_at BB144704 Abca1 Mm.277376 1417889_at NM_009694 Apobec2 Mm.281793 1422140_at NM_033616 1423555_a_at BB329808 Ifi44 Mm.30756 1450240_a_at NM_031393 Sytl1 Mm.25660 1425716_s_at AF402617 Bak1 Mm.2443 1418020_s_at NM_007754 Cpd Mm.276736 1452439_s_at AF250135 Sfrs2 Mm.21841 1430053_a_at AK019142 2810409H07Rik Mm.22661 1419024_at BC003761 Ptp4a1 Mm.262000 1423072_at AW549928 6720475J19Rik Mm.275739 1450783_at NM_008331 Ifit1 Mm.6718 1438676_at BM241485 AI595338 Mm.354723 1422892_s_at U13648 H2-Ea Mm.15680 Table S2:Probe sets with significant variation in human datasets from the Mouse AKR vs DBA tumor comparison Probe set GSE1456 GSE2034 GSE3494 GSE4922 Rosetta Gene Symbol Gene Title 200008_s_at 200008_s_at200008_s_at200008_s_at200008_s_at 0 GDI2 GDP dissociation inhibitor 2 200009_at 200009_at 0 200009_at 200009_at 0 GDI2 GDP dissociation inhibitor 2 200011_s_at 200011_s_at 0 200011_s_at200011_s_at 0 ARF3 ADP-ribosylation factor 3 200618_at 200618_at 0 200618_at 200618_at NM_006148 LASP1 LIM and SH3 protein 1 200625_s_at 200625_s_at 0 0 0 0 CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 200730_s_at 200730_s_at 0 200730_s_at200730_s_atNM_003463 PTP4A1 protein tyrosine phosphatase type IVA, member 1 200731_s_at 200731_s_at 0 200731_s_at200731_s_atNM_003463 PTP4A1 protein tyrosine phosphatase type IVA, member 1 200732_s_at 200732_s_at 0 200732_s_at200732_s_atNM_003463 PTP4A1 protein tyrosine phosphatase type IVA, member 1 200733_s_at 200733_s_at 0 200733_s_at200733_s_atNM_003463 PTP4A1 protein tyrosine phosphatase type IVA, member 1 200734_s_at 200734_s_at 0 200734_s_at200734_s_at 0 ARF3 ADP-ribosylation factor 3 200752_s_at 200752_s_at 0 0 0 0 CAPN1 calpain 1, (mu/I) large subunit 200753_x_at 200753_x_at 0 200753_x_at200753_x_at 0 SFRS2 splicing factor, arginine/serine-rich 2 200841_s_at 200841_s_at200841_s_at200841_s_at200841_s_atNM_004446 EPRS glutamyl-prolyl-tRNA synthetase 200842_s_at 200842_s_at200842_s_at200842_s_at200842_s_atNM_004446 EPRS glutamyl-prolyl-tRNA synthetase 200843_s_at 200843_s_at 0 200843_s_at200843_s_atNM_004446 EPRS glutamyl-prolyl-tRNA synthetase 200887_s_at 200887_s_at 0 200887_s_at200887_s_atNM_007315 STAT1 signal transducer and activator of transcription 1, 91kDa 201138_s_at 201138_s_at 0 201138_s_at201138_s_atNM_003142 SSB Sjogren syndrome antigen B (autoantigen La) 201139_s_at 201139_s_at 0 0 0 NM_003142 SSB Sjogren syndrome antigen B (autoantigen La) 201183_s_at 201183_s_at 0 201183_s_at201183_s_at 0 CHD4 chromodomain helicase DNA binding protein 4 201367_s_at 201367_s_at201367_s_at201367_s_at201367_s_at 0 ZFP36L2 zinc finger protein 36, C3H type-like 2 201368_at 201368_at 0 201368_at 201368_at 0 ZFP36L2 zinc finger protein 36, C3H type-like 2 201369_s_at 201369_s_at201369_s_at201369_s_at201369_s_at 0 ZFP36L2 zinc finger protein 36, C3H type-like 2 201394_s_at 201394_s_at 0 201394_s_at201394_s_atNM_005778 RBM5 RNA binding motif protein 5 201416_at 201416_at