ALLOCATION ROUND 3: Pfizer-Biontech Vaccine, April – June 2021
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Gavi's Vaccine Investment Strategy
Gavi’s Vaccine Investment Strategy Deepali Patel THIRD WHO CONSULTATION ON GLOBAL ACTION PLAN FOR INFLUENZA VACCINES (GAP III) Geneva, Switzerland, 15-16 November 2016 www.gavi.org Vaccine Investment Strategy (VIS) Evidence-based approach to identifying new vaccine priorities for Gavi support Strategic investment Conducted every 5 years decision-making (rather than first-come- first-serve) Transparent methodology Consultations and Predictability of Gavi independent expert advice programmes for long- term planning by Analytical review of governments, industry evidence and modelling and donors 2 VIS is aligned with Gavi’s strategic cycle and replenishment 2011-2015 Strategic 2016-2020 Strategic 2021-2025 period period 2008 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 RTS,S pilot funding decision VIS #1 VIS #2 VIS #3 MenA, YF mass campaigns, JE, HPV Cholera stockpile, Mid 2017 : vaccine ‘long list’ Rubella, Rabies/cholera studies, Oct 2017 : methodology Typhoid Malaria – deferred Jun 2018 : vaccine shortlist conjugate Dec 2018 : investment decisions 3 VIS process Develop Collect data Develop in-depth methodology and Apply decision investment decision framework for cases for framework with comparative shortlisted evaluation analysis vaccines criteria Phase I Narrow long list Phase II Recommend for Identify long list to higher priority Gavi Board of vaccines vaccines approval of selected vaccines Stakeholder consultations and independent expert review 4 Evaluation criteria (VIS #2 – 2013) Additional Health Implementation -
1 Economic Outlook from Mauritius the COVID-19 Pandemic Is
Economic outlook from Mauritius The COVID-19 pandemic is severely impacting on the world economy. In 2020, global output contracted by 3.5%. In Mauritius, GDP fell by around 15.2% in real terms. Bold measures taken by Government to mitigate the negative impact of the pandemic on the economy and save thousands of jobs – • Wage Assistance Scheme; • Self-Employed Assistance Scheme and • Other support provided to businesses and individuals. The significant costs of these support schemes, together with the shortfall in tax revenue arising from the contraction in economic activities, have weighed heavily on public finances, leading to a rise in public sector debt. With the gradual rollout of vaccine programmes and additional fiscal support across countries, global economic prospects for 2021 have improved. Main concern of Government is, therefore, to direct our resources and efforts towards policy responses that will help us ride through the negative impact of the second lockdown, strengthen our economic recovery, boost investment, create more employment opportunities, address public health and climate change issues, while at the same time embarking on a medium-term fiscal consolidation programme. Budget 2021/2022 will focus mainly on reducing recurrent expenditure by 25% compared to the voted provisions for FY 2020-2021, implementing projects and schemes that have high impact on growth and job creation and reviewing processes and procedures to ensure effective and timely implementation of projects, and improvement in service delivery. 1 Financing options for the vaccination programme Health is considered as a basic human right and is free of user cost in Mauritius. The Expanded Immunisation Programme covers 100 % of the population. -
Yellow Fever 2016
Resident / Humanitarian Coordinator Report on the use of CERF funds RESIDENT / HUMANITARIAN COORDINATOR REPORT ON THE USE OF CERF FUNDS ANGOLA RAPID RESPONSE YELLOW FEVER 2016 RESIDENT/HUMANITARIAN COORDINATOR Pier Paolo Balladelli REPORTING PROCESS AND CONSULTATION SUMMARY a. Please indicate when the After Action Review (AAR) was conducted and who participated. Review agreed on 02/09/2016 and 07/09/2016. b. Please confirm that the Resident Coordinator and/or Humanitarian Coordinator (RC/HC) Report was discussed in the Humanitarian and/or UN Country Team and by cluster/sector coordinators as outlined in the guidelines. YES NO c. Was the final version of the RC/HC Report shared for review with in-country stakeholders as recommended in the guidelines (i.e. the CERF recipient agencies and their implementing partners, cluster/sector coordinators and members and relevant government counterparts)? YES NO Final version shared with UNICEF and UNDP, although this initiative was mainly implemented by WHO 2 I. HUMANITARIAN CONTEXT TABLE 1: EMERGENCY ALLOCATION OVERVIEW (US$) Total amount required for the humanitarian response: Source Amount CERF 3,000,000 Breakdown of total response COUNTRY-BASED POOL FUND (if applicable) 4,508,559 funding received by source OTHER (bilateral/multilateral) TOTAL 10,473,618 *The total amount does not match because this was considered an underfunded emergency. TABLE 2: CERF EMERGENCY FUNDING BY ALLOCATION AND PROJECT (US$) Allocation 1 – date of official submission: 06/04/2016- 05/10/2016 Agency Project code Cluster/Sector -
Hanna Nohynek @Hnohynek
Biosketch Hanna Nohynek @hnohynek Hanna Nohynek is Chief Physician and Deputy Head of the Infectious Diseases Control and Vaccines Unit of the Department of Health Security at the Finnish Institute for Health and Welfare. She serves as secretary of the Finnish NITAG (KRAR), and leads the subgroup on Strategic development of the influenza vaccination programme and the subgroup on the SARS-CoV-2 vaccination strategy. She practices clinical medicine at a travel health clinic in Aava, Helsinki. She was instrumental in designing the first THL (KTL) health advisory for refugees and asylum seekers in Finland, studying the narcolepsy signal post pandemic vaccination, designing the introduction of the HPV vaccine to the national immunization programme, and the introduction of the live attenuated influenza vaccine for children. Her present research interests are register-based vaccine impact studies, evidence based policy/decision making, vaccine safety, hesitancy, SARS-CoV-2, RSV, influenza and pneumococcus. She coordinates the work packages on field studies and communication for IMI DRIVE on brand specific influenza vaccine effectiveness (www.drive-eu.org). She has authored more than 130 original articles (including the first scientific report on the association between pandemic influenza vaccination and narcolepsy), and she teaches, giving over 30 invited lectures annually and guiding elective, graduate and PhD students (presently Raija Auvinen and Idil Hussein). She belongs to the external faculty of the University of Tampere MSc course on Global Health. She has served on expert committees evaluating HBV, PCV and rota virus vaccines in Finland, and as an advisor to the EU, IMI, IVI, WHO, GAVI, SIDA/SRC, and the Finnish MOFA. -
UNEP Mercury Treaty Protects Access to Thiomersal-Containing Vaccines
UNEP mercury treaty protects access to thiomersal-containing vaccines United Nations Environment Program has developed a treaty on mercury in an effort to protect human health and the environment by limiting mercury releases. In the course of the negotiations, a proposal was made to restrict vaccines that contain the preservative thiomersal under a section of the treaty that prohibits trade of mercury-added products. The implications of restricting thiomersal, an ethyl mercury-containing preservative, would be significant. According to SAGE, “Thiomersal-containing vaccines [are] safe, essential, and irreplaceable components of immunization programs, especially in developing countries, and…removal of these products would disproportionately jeopardize the health and lives of the most disadvantaged children worldwide.” The treaty annex that describes prohibited products specifically excludes “vaccines containing thiomersal as preservatives” under a short list of products the authors intended to emphasize were to be protected. Protecting access to vaccines came as the result of a strong partnership between WHO, UNICEF, GAVI, and civil society advocates and experts around the world to educate country delegates, who predominantly came from ministries of environment. This was also a wonderful partnership with animal health experts, who similarly rely on thiomersal for veterinary vaccines. By facilitating communication between ministries of health and ministries of environment, strong statements are made by delegates about the essential role of thiomersal-containing vaccines in protecting human health. PATH will be collecting and disseminating additional information about how the community came together around this issue and lessons learned in the coming months. . -
Medical Discrimination in the Time of COVID-19: Unequal Access to Medical Care in West Bank and Gaza Hana Cooper Seattle University ‘21, B.A
Medical Discrimination in the Time of COVID-19: Unequal Access to Medical Care in West Bank and Gaza Hana Cooper Seattle University ‘21, B.A. History w/ Departmental Honors ABSTRACT INTRODUCTION AND PURPOSE A SYSTEM OF DISCRIMINATION COVID-19 IMPACT Given that PalestiniansSTRACT are suffering from As is evident from headlines over the last year, Palestinians are faring much worse While many see the founding of Israel in 1948 as the beginning of discrimination against COVID-19 has amplified all of the existing issues of apartheid, which had put Palestinians the COVID-19 pandemic not only to a under the COVID-19 pandemic than Israelis. Many news sources focus mainly on the Palestinians, it actually extends back to early Zionist colonization in the 1920s. Today, in a place of being less able to fight a pandemic (or any major, global crisis) effectively. greater extent than Israelis, but explicitly present, discussing vaccine apartheid and the current conditions of West Bank, Gaza, discrimination against Palestinians continues at varying levels throughout West Bank, because of discriminatory systems put into and Palestinian communities inside Israel. However, few mainstream news sources Gaza, and Israel itself. Here I will provide some examples: Gaza Because of the electricity crisis and daily power outages in Gaza, medical place by Israel before the pandemic began, have examined how these conditions arose in the first place. My project shows how equipment, including respirators, cannot run effectively throughout the day, and the it is clear that Israel is responsible for taking the COVID-19 crisis in Palestine was exacerbated by existing structures of Pre-1948 When the infrastructure of what would eventually become Israel was first built, constant disruptions in power cause the machines to wear out much faster than they action to ameliorate the crisis. -
Cheat Sheet: COVID-19 Vaccine Pipeline
Cheat Sheet: COVID-19 vaccine pipeline Primary sponsor(s) Description Platform Funders Status Considerations Read more Pfizer / BioNTech Comirnaty mRNA Pfizer ($500M) Ph. I/II ongoing: 456/Germany Efficacy: Interim analysis shows that the candidate was safe and well-tolerated with New York Times mRNA that encodes for USG ($1.9M) Ph. II planned: 960/China an efficacy rate of 95%. SARS-CoV-2 spike protein. Warp Speed Finalist Ph. II/III ongoing: 44K US +5 Manufacturing/delivery: mRNA vaccines are relatively easy to scale and Authorization: EUA in EU, US, +9; WHO manufacture. Emergency Validation Platform history: No previous mRNA vaccines licensed for use. Approval: Bahrain, New Zealand, Saudi Arabia, Switzerland Moderna mRNA-1273 mRNA USG ($2.48B) Ph. I ongoing: 155/US Efficacy: Interim analysis shows that the candidate was safe and well-tolerated Moderna Synthetic messenger RNA CEPI/GAVI (Undisclosed) Ph. II/III ongoing: 3000 (12 to 17 years)/ US with an efficacy rate of 94.5%. Statement that encodes for SARS- Warp Speed Finalist Ph. III ongoing: 30,000/US Manufacturing/delivery: mRNA vaccines are relatively easy to scale and CoV-2 spike protein. COVAX Portfolio Authorization: EUA in Canada, EU, manufacture (potential for 1B doses by 2022); likely to require two doses, but a AVAC Israel, US third may be necessary. Webinar Approval: Switzerland Platform history: No previous mRNA vaccines licensed for use. U. of Oxford AZD1222 Viral USG ($1.2B) Ph. II ongoing: 300 vols (6-17 years)/ UK Efficacy: Ph. III interim analysis shows vaccine was safe and well-tolerated, efficacy Science AstraZeneca Chimpanzee Adeno vector vector CEPI/GAVI ($750M) Ph. -
Yellow Fever Vaccine
Yellow Fever Vaccine: Current Supply Outlook UNICEF Supply Division May 2016 0 Yellow Fever Vaccine - Current Supply Outlook May 2016 This update provides revised information on yellow fever vaccine supply availability and increased demand. Despite slight improvements in availability and the return of two manufacturers from temporary suspension, a constrained yellow fever vaccine market will persist through 2017, exacerbated by current emergency outbreak response requirements. 1. Summary Yellow fever vaccine (YFV) supply through UNICEF remains constrained due to limited production capacity. Despite the return of two manufacturers from temporary suspension, the high demand currently generated from the yellow fever (YF) outbreak in Angola, in addition to potential increased outbreak response requirements in other geographic regions, outweigh supply. The demand in response to the current YF outbreak in Angola could negatively impact the supply availability for some routine immunization programme activities. UNICEF anticipates a constrained global production capacity to persist through 2017. UNICEF has long-term arrangements (LTAs) with four YFV suppliers to cover emergency stockpile, routine immunization, and preventative campaign requirements. During 2015, UNICEF increased total aggregate awards to suppliers to reach approximately 98 million doses for 2016- 2017. However, whereas supply can meet emergency stockpile and routine requirements, it is insufficient to meet all preventive campaign demands, which increased the total demand through UNICEF to 109 million doses. The weighted average price (WAP) per dose for YFV increased 7% a year on average since 2001, from US$ 0.39 to reach US$ 1.04 in 2015. Given the continued supply constraints, UNICEF anticipates a YFV WAP per dose of US$1.10 in the near-term. -
An Overview of COVID Vaccine Clinical Trial Results & Some Challenges
An overview of COVID vaccine clinical trial results & some challenges DCVMN Webinar December 8th, 2020 Access to COVID-19 tools ACCESSACCESS TO TOCOVID-19 COVID-19 TOOLS TOOLS (ACT) (ACT) ACCELERATOR ACCELERATOR (ACT) accelerator A GlobalA GlobalCollaboration Collaboration to Accelerate tothe AccelerateDevelopment, the Production Development, and Equitable Production Access to New and Equitable AccessCOVID-19 to New diagnostics, COVID-19 therapeutics diagnostics, and vaccines therapeutics and vaccines VACCINES DIAGNOSTICS THERAPEUTICS (COVAX) Development & Manufacturing Led by CEPI, with industry Procurement and delivery at scale Led by Gavi Policy and allocation Led by WHO Key players SOURCE: (ACT) ACCELERATOR Commitment and Call to Action 24th April 2020 ACT-A / COVAX governance COVAX COORDINATION MEETING CEPI Board Co-Chair: Jane Halton Co-Chair: Dr. Ngozi Gavi Board Workstream leads + DCVMN and IFPMA-selected Reps As needed – R&D&M Chair; COVAX IPG Chair Development & Manufacturing Procurement and delivery Policy and allocation (COVAX) at scale Led by (with industry) Led by Led by R&D&M Investment Committee COVAX Independent Product Group Technical Review Group Portfolio Group Vaccine Teams SWAT teams RAG 3 COVAX SWAT teams are being set up as a joint platform to accelerate COVID- 19 Vaccine development and manufacturing by addressing common challenges together Timely and targeted Multilateral Knowledge-based Resource-efficient Addresses specific cross- Establishes a dialogue Identifies and collates Coordinates between developer technical and global joint effort most relevant materials different organizations/ challenges as they are across different COVID-19 and insights across the initiatives to limit raised and/or identified vaccines organizations broader COVID-19 duplications and ensure on an ongoing basis (incl. -
Adviser, Country Engagement – COVAX
Terms of Reference – Adviser, Country Engagement – COVAX Adviser, Country Engagement – COVAX Program Background Gavi, the Vaccine Alliance is a public-private partnership committed to saving children's lives and protecting people's health by increasing equitable use of vaccines in lower-income countries. The Vaccine Alliance brings together developing country and donor governments, the World Health Organization, UNICEF, the World Bank, the vaccine industry, technical agencies, civil society, the Bill & Melinda Gates Foundation and other private sector partners. Gavi uses innovative finance mechanisms, including co-financing by recipient countries, to secure sustainable funding and adequate supply of quality vaccines. Since 2000, Gavi has contributed to the immunisation of nearly 760 million children and the prevention of more than 13 million future deaths. Gavi is committed to securing a global response to COVID-19 that is effective and fair, using its unique expertise to help identify and rapidly accelerate development, production and delivery of COVID-19 vaccines under the principle that no one is safe unless everyone is safe. As part of broader efforts to secure equitable access to COVID-19 vaccines, Gavi has launched the COVID- 19 Vaccines Global Access (COVAX) Facility. All countries are invited to participate in this Facility, which will pool demand and resources and secure supply of COVID-19 vaccines through entering advance purchase commitments with manufacturers. The Gavi Secretariat is currently coordinating efforts together with global health partners to complete the design of this Facility and begin operationalising, with the goal of securing 2 billion doses by the end of 2021 to vaccinate the highest priority populations globally. -
Mozambiquemozambique
MOZAMBIQUEMOZAMBIQUE HumanitarianHumanitarian Situation ReportReport No.5 5 Reporting Period: 1 January – 30 June 2021 Situation in Numbers Highlights 689,000 • COVID-19 cases increased swiftly in June as children in need of Mozambique entered its third wave; only 1 percent of the humanitarian assistance target population (54% of the country) is vaccinated. 1.3 million • Since the attack on Palma in late March, over 70,000 people in need people have left the district. (OCHA Dec 2020) • Each month UNICEF reaches an estimated 12 million people COVID-19 messages to promote prevention and 732,000 create vaccine demand. Internally displaced (IOM, April 2021) • Nearly 511,000 children under five were screened for acute malnutrition and over 294,000 children under 15 >70,000 were immunized for measles and rubella. Internally displaced from • UNICEF support government cash transfers to over Palma 20,000 households. (IOM, July 2021) UNICEF’s Response and Funding Status UNICEF Appeal 2021 US$ 96.5 million 1 Funding Overview and Partnerships UNICEF’s 2021 Humanitarian Action for Children appeal, revised in June 2021 due to escalating needs, requests $96.5 million to provide lifesaving and life-sustaining services for children and their caregivers in Mozambique. Thus far in 2021, UNICEF Mozambique has received $16.3 million for its humanitarian response from the Governments of Canada, Japan, Norway, Sweden, Italy, and the United Kingdom, as well as support from Education Cannot Wait and the UN’s Central Emergency Response Fund. This includes allocations from UNICEF’s unearmarked global humanitarian funding in the amount of $3.9 million. UNICEF expresses its sincere gratitude to all our donors. -
Human Papillomavirus Vaccine
Human Papillomavirus Vaccine: Supply and Demand Update UNICEF Supply Division October 2020 0 Human Papillomavirus Vaccine Supply and Demand Update - October 2020 This update provides information on human papillomavirus vaccine, including supply, demand, and pricing trends. It highlights continued supply constraints foreseen over 2020 and 2021, which also affects countries procuring through UNICEF. UNICEF requests self-financing middle-income countries to consolidate credible multi-year demand and to submit multi-year commitments through UNICEF. 1. Summary • UNICEF’s strategic plan for 2018-2021 seeks to ensure that at least 24 countries nationally introduce human papillomavirus (HPV) vaccine into their immunization programmes.1 As of to date, 20 countries supplied through UNICEF, of which 15 supported by Gavi, the Vaccine Alliance (Gavi) and five countries having transitioned from Gavi support and self-finance their procurement, have introduced HPV vaccines since 2013. Fourteen middle-income countries (MICs) are also procuring HPV vaccines through UNICEF. From 2013 to 2019, UNICEF’s total HPV vaccine procurement reached 30.9 million doses in support of girls. There is currently no gender-neutral programmes in countries supplied through UNICEF. Of the 30.9 million doses, UNICEF procured 28.3 million doses (91 per cent) for countries supported by Gavi, including those that transitioned from Gavi support and still access Gavi prices, and 2.6 million doses (9 per cent) on behalf of self-financing MICs. • In December 2016, Gavi revised its programme strategy to support full-scale national HPV vaccine introductions with multi-age cohort (MAC) vaccinations. This substantially increased HPV vaccine demand through UNICEF from 2017.