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MINIREVIEW Rice R Past and Present Perspectives on ␤-Lactamases e01076-18 Minireview Karen Bush

MECHANISMS OF ACTION: PHYSIOLOGICAL EFFECTS Rice T Studies on Aminoglycoside Susceptibility Identify a Novel Function of KsgA To e00853-18 Mech of Action Secure Translational Fidelity during Antibiotic Stress Jin Zou, Wenwen Zhang, Hongjie Zhang, Xiaohua Douglas Zhang, Bo Peng, Jun Zheng Silverman T Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium e00925-18 Mech of Action difficile Infection Charles Burdet, Sakina Sayah-Jeanne, Thu Thuy Nguyen, Perrine Hugon, Frédérique Sablier-Gallis, Nathalie Saint-Lu, Tanguy Corbel, Stéphanie Ferreira, Mark Pulse, William Weiss, Antoine Andremont, France Mentré, Jean de Gunzburg

MECHANISMS OF RESISTANCE Arias T Sulfide Protects Staphylococcus aureus from Aminoglycoside Antibiotics but e00602-18 Mech of Resistance Cannot Be Regarded as a General Defense Mechanism against Antibiotics Julia Weikum, Niklas Ritzmann, Nils Jelden, Anna Klöckner, Sebastian Herkersdorf, Michaele Josten, Hans-Georg Sahl, Fabian Grein Doi S Coidentification of mcr-4.3 and bla in a Clinical Enterobacter cloacae Isolate e00649-18 Mech of Resistance NDM-1 from China Bhakti Chavda, Jingnan Lv, Mengyun Hou, Kalyan D. Chavda, Barry N. Kreiswirth, Youjun Feng, Liang Chen, Fangyou Yu Arias T Loss-of-Function Mutations in epaR Confer Resistance to ␾NPV1 Infection in e00758-18 Mech of Resistance Enterococcus faecalis OG1RF Khang Ho, Wenwen Huo, Savannah Pas, Ryan Dao, Kelli L. Palmer Doi T In Silico Typing and Comparative Genomic Analysis of IncFII Plasmids and e00764-18 Mech of Resistance K Insights into the Evolution of Replicons, Plasmid Backbones, and Resistance Determinant Profiles Dexi Bi, Jiayi Zheng, Jun-Jie Li, Zi-Ke Sheng, Xingchen Zhu, Hong-Yu Ou, Qianyu Li, Qing Wei Arikan-Akdagli S First Clinical Isolation of an Azole-Resistant Aspergillus fumigatus Isolate e00872-18 Mech of Resistance Harboring a TR46 Y121F T289A Mutation in South America Guillermina Isla, Florencia Leonardelli, Iris N. Tiraboschi, Nicolás Refojo, Alejandra Hevia, Walter Vivot, Wanda Szusz, Susana B. Córdoba, Guillermo García-Effron Dooley T Validation of Novel Mycobacterium tuberculosis Isoniazid Resistance Mutations e00974-18 Mech of Resistance Not Detectable by Common Molecular Tests Justin L. Kandler, Alexandra D. Mercante, Tracy L. Dalton, Matthew N. Ezewudo, Lauren S. Cowan, Scott P. Burns, Beverly Metchock, on behalf of Global PETTS Investigators, Peter Cegielski, James E. Posey Andes T The PA3177 Gene Encodes an Active Diguanylate Cyclase That Contributes to e01049-18 Mech of Resistance Biofilm Antimicrobial Tolerance but Not Biofilm Formation by Pseudomonas aeruginosa Bandita Poudyal, Karin Sauer

Instructions to Authors are available on the journal website. CONTENTS • OCTOBER 2018 • VOLUME 62, NO. 10

Andes T Relative Contribution of the ABC Transporters Cdr1, Pdh1, and Snq2 to Azole e01070-18 Mech of Resistance Resistance in Candida glabrata Sarah G. Whaley, Qing Zhang, Kelly E. Caudle, P. David Rogers Dooley T Characterization of Mutations Conferring Resistance to Rifampin in e01093-18 Mech of Resistance Mycobacterium tuberculosis Clinical Strains Tomasz Jagielski, Zofia Bakuła, Anna Brzostek, Alina Minias, Radosław Stachowiak, Joanna Kalita, Agnieszka Napiórkowska, Ewa Augustynowicz-Kopec´, Anna Z˙aczek, Edita Vasiliauskiene, Jacek Bielecki, Jarosław Dziadek Doi T Characterization of the AmpC ␤-Lactamase from Burkholderia multivorans e01140-18 Mech of Resistance Scott A. Becka, Elise T. Zeiser, Melissa D. Barnes, Magdalena A. Taracila, Kevin Nguyen, Indresh Singh, Granger G. Sutton, John J. LiPuma, Derrick E. Fouts, Krisztina M. Papp-Wallace Doi S Genetic and Biochemical Characterization of OXA-535, a Distantly Related e01198-18 Mech of Resistance OXA-48-Like ␤-Lactamase L. Dabos, A. B. Jousset, R. A. Bonnin, N. Fortineau, A. Zavala, P. Retailleau, B. I. Iorga, T. Naas Shlaes T Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro e01200-18 Mech of Resistance Susceptibility in Escherichia coli and Klebsiella pneumoniae Charles R. Dean, David T. Barkan, Alun Bermingham, Johanne Blais, Fergal Casey, Anthony Casarez, Richard Colvin, John Fuller, Adriana K. Jones, Cindy Li, Sara Lopez, Louis E. Metzger IV, Mina Mostafavi, Ramadevi Prathapam, Dita Rasper, Folkert Reck, Alexey Ruzin, Jacob Shaul, Xiaoyu Shen, Robert L. Simmons, Peter Skewes-Cox, Kenneth T. Takeoka, Pramila Tamrakar, Tsuyoshi Uehara, Jun-Rong Wei Shlaes S Impact of Inducible bla on Susceptibility of Klebsiella pneumoniae Clinical e01202-18 Mech of Resistance DHA-1 Isolates to LYS228 and Identification of Chromosomal mpl and ampD Mutations

Mediating Upregulation of Plasmid-Borne blaDHA-1 Expression Adriana K. Jones, Srijan Ranjitkar, Sara Lopez, Cindy Li, Johanne Blais, Folkert Reck, Charles R. Dean Doi T Genetic Determinants of Penicillin Tolerance in Vibrio cholerae e01326-18 Mech of Resistance Anna I. Weaver, Shannon G. Murphy, Benjamin D. Umans, Srikar Tallavajhala, Ikenna Onyekwere, Stephen Wittels, Jung-Ho Shin, Michael VanNieuwenhze, Matthew K. Waldor, Tobias Dörr Doi T Mutation-Driven Evolution of Pseudomonas aeruginosa in the Presence of either e01379-18 Mech of Resistance Ceftazidime or Ceftazidime-Avibactam Fernando Sanz-García, Sara Hernando-Amado, José Luis Martínez Andes S Limited ERG11 Mutations Identified in Isolates of Candida auris Directly e01427-18 Mech of Resistance Contribute to Reduced Azole Susceptibility Kelley R. Healey, Milena Kordalewska, Cristina Jiménez Ortigosa, Ashutosh Singh, Indira Berrío, Anuradha Chowdhary, David S. Perlin

SUSCEPTIBILITY Milhous T Novel Approaches To Kill Toxoplasma gondii by Exploiting the Uncontrolled e00347-18 Susceptibility Uptake of Unsaturated Fatty Acids and Vulnerability to Lipid Storage Inhibition of the Parasite Sabrina J. Nolan, Julia D. Romano, John T. Kline, Isabelle Coppens

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Boucher T In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug- e00552-18 Susceptibility Resistant Enterobacteriaceae Johanne Blais, Sara Lopez, Cindy Li, Alexey Ruzin, Srijan Ranjitkar, Charles R. Dean, Jennifer A. Leeds, Anthony Casarez, Robert L. Simmons, Folkert Reck Shlaes T Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant e00873-18 Susceptibility Enterobacteriaceae Thea Brennan-Krohn, Alejandro Pironti, James E. Kirby Andes T Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris e01084-18 Susceptibility Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development Gina Wall, Ashok K. Chaturvedi, Floyd L. Wormley, Jr., Nathan P. Wiederhold, Hoja P. Patterson, Thomas F. Patterson, José L. Lopez-Ribot Dooley S Minocycline Has No Clear Role in the Treatment of Mycobacterium abscessus Disease e01208-18 Susceptibility Mike M. Ruth, Jasper J. N. Sangen, Lian J. Pennings, Jodie A. Schildkraut, Wouter Hoefsloot, Cecile Magis-Escurra, Heiman F. L. Wertheim, Jakko van Ingen Arikan-Akdagli T APX001A In Vitro Activity against Contemporary Blood Isolates and Candida e01225-18 Susceptibility auris Determined by the EUCAST Reference Method Maiken Cavling Arendrup, Anuradha Chowdhary, Karen M. T. Astvad, Karin Meinike Jørgensen

BIOLOGIC RESPONSE MODIFIERS Silverman T Effect of the Synthetic Bile Salt Analog CamSA on the Hamster Model of e02251-17 Modifiers Clostridium difficile Infection Amber Howerton, Cale O. Seymour, Senthil K. Murugapiran, Zhenlin Liao, Jacqueline R. Phan, Alan Estrada, Adam J. Wagner, Chrisabelle C. Mefferd, Brian P. Hedlund, Ernesto Abel-Santos

ANTIVIRAL AGENTS Martinez T Sensitivity of the C-Terminal Nuclease Domain of Kaposi’s Sarcoma-Associated e00233-18 Antiviral Herpesvirus ORF29 to Two Classes of Active-Site Ligands Jennifer T. Miller, Haiyan Zhao, Takashi Masaoka, Brittany Varnado, Elena M. Cornejo Castro, Vickie A. Marshall, Kaivon Kouhestani, Anna Y. Lynn, Keith E. Aron, Anqi Xia, John A. Beutler, Danielle R. Hirsch, Liang Tang, Denise Whitby, Ryan P. Murelli, Stuart F. J. Le Grice Martinez T Development and Validation of a Phenotypic High-Content Imaging Assay for e00725-18 Antiviral Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus Jean A. Bernatchez, Zunhua Yang, Michael Coste, Jerry Li, Sungjun Beck, Yan Liu, Alex E. Clark, Zhe Zhu, Lucas A. Luna, Christal D. Sohl, Byron W. Purse, Rongshi Li, Jair L. Siqueira-Neto Martinez T Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the e00835-18 Antiviral Hepatitis B Virus Life Cycle Thomas Lahlali, Jan Martin Berke, Karen Vergauwen, Adrien Foca, Koen Vandyck, Frederik Pauwels, Fabien Zoulim, David Durantel Martinez T Extended-Duration MK-8591-Eluting Implant as a Candidate for HIV Treatment e01058-18 Antiviral and Prevention Stephanie E. Barrett, Ryan S. Teller, Seth P. Forster, Li Li, Megan A. Mackey, Daniel Skomski, Zhen Yang, Kerry L. Fillgrove, Gregory J. Doto, Sandra L. Wood, Jose Lebron, Jay A. Grobler, Rosa I. Sanchez, Zhen Liu, Bing Lu, Tao Niu, Li Sun, Marian E. Gindy

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Martinez T No Resistance to Tenofovir Alafenamide Detected through 96 Weeks of e01064-18 Antiviral Treatment in Patients with Chronic Hepatitis B Infection Andrea L. Cathcart, Henry Lik-Yuen Chan, Neeru Bhardwaj, Yang Liu, Patrick Marcellin, Calvin Q. Pan, Shalimar, Maria Buti, Stephanie Cox, Bandita Parhy, Eric Zhou, Ross Martin, Silvia Chang, Lanjia Lin, John F. Flaherty, Kathryn M. Kitrinos, Anuj Gaggar, Namiki Izumi, Young-Suk Lim Martinez T Pooled Resistance Analysis in Patients with Hepatitis C Virus Genotype 1 to 6 e01249-18 Antiviral Infection Treated with Glecaprevir-Pibrentasvir in Phase 2 and 3 Clinical Trials Preethi Krishnan, Tami Pilot-Matias, Gretja Schnell, Rakesh Tripathi, Teresa I. Ng, Thomas Reisch, Jill Beyer, Tatyana Dekhtyar, Michelle Irvin, Wangang Xie, Lois Larsen, Federico J. Mensa, Christine Collins Martinez S In Vitro Antiviral Activity of Cabotegravir against HIV-2 e01299-18 Antiviral Robert A. Smith, Vincent H. Wu, Christopher G. Zavala, Dana N. Raugi, Selly Ba, Moussa Seydi, Geoffrey S. Gottlieb, for the University of Washington-Dakar HIV-2 Study Group

EPIDEMIOLOGY AND SURVEILLANCE Milhous S Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas e00354-18 Epidemiology Where the Parasite Is Endemic Larissa Rodrigues Gomes, Aline Lavigne, Cassio Leonel Peterka, Patrícia Brasil, Didier Ménard, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz Doi T Extensive Genetic Commonality among Wildlife, Wastewater, Community, and e00519-18 Epidemiology Nosocomial Isolates of Escherichia coli Sequence Type 131 (H30R1 and H30Rx

Subclones) That Carry blaCTX-M-27 or blaCTX-M-15 Ivana Jamborova, Brian D. Johnston, Ivo Papousek, Katerina Kachlikova, Lenka Micenkova, Connie Clabots, Anna Skalova, Katerina Chudejova, Monika Dolejska, Ivan Literak, James R. Johnson Doi S Various Sequence Types of Enterobacteriaceae Isolated from Commercial Chicken e00779-18 Epidemiology Farms in China and Carrying the blaNDM-5 Gene Rong Xiang, An-Yun Zhang, Xiao-Lan Ye, Zhuang-Zhuang Kang, Chang-Wei Lei, Hong-Ning Wang Chambers T Trend and Pattern of Antimicrobial Resistance in Molluscan Vibrio Species e00799-18 Epidemiology Sourced to Canadian Estuaries Swapan K. Banerjee, Jeffrey M. Farber Chambers T Clinical and Molecular Correlates of Escherichia coli Bloodstream Infection from e00937-18 Epidemiology Two Geographically Diverse Centers in Rochester, Minnesota, and Singapore Shehara M. Mendis, Shawn Vasoo, Brian D. Johnston, Stephen B. Porter, Scott A. Cunningham, Sanjay R. Menon, Christine B. Teng, Partha P. De, Robin Patel, James R. Johnson, Ritu Banerjee Andes T In Vitro Activity of Isavuconazole against Opportunistic Fungal Pathogens from e01230-18 Epidemiology Two Mycology Reference Laboratories Michael A. Pfaller, Paul R. Rhomberg, Nathan P. Wiederhold, Connie Gibas, Carmita Sanders, Hongxin Fan, James Mele, Laura L. Kovanda, Mariana Castanheira

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EXPERIMENTAL THERAPEUTICS Andes T Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 e00425-18 Experimental against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis Yanan Zhao, Min Hee Lee, Padmaja Paderu, Annie Lee, Cristina Jimenez-Ortigosa, Steven Park, Robert S. Mansbach, Karen Joy Shaw, David S. Perlin Dooley T Effective Treatment of Mycobacterium avium subsp. hominissuis and e00440-18 Experimental Mycobacterium abscessus Species Infections in Macrophages, Biofilm, and Mice by Using Liposomal Ciprofloxacin James D. Blanchard, Valerie Elias, David Cipolla, Igor Gonda, Luiz E. Bermudez Milhous T Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for e00603-18 Experimental Anti-Leishmania Therapy Victor Sebastián-Pérez, Sarah Hendrickx, Jane C. Munday, Titilola Kalejaiye, Ana Martínez, Nuria E. Campillo, Harry de Koning, Guy Caljon, Louis Maes, Carmen Gil Milhous S Broad Spectrum and Safety of Oral Treatment with a Promising Nitrosylated e00792-18 Experimental Chalcone in Murine Leishmaniasis Ariane J. Sousa-Batista, Douglas Escrivani-Oliveira, Camila Alves Bandeira Falcão, Cintia Iana Monteiro da Silva Philipon, Bartira Rossi-Bergmann Milhous T Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing e00832-18 Experimental Chronic Cardiac Pathology in Experimental Models of Chagas Disease Amanda Fortes Francisco, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly Boucher S Evaluation of Oritavancin Combinations with Rifampin, Gentamicin, or Linezolid e00943-18 Experimental against Prosthetic Joint Infection-Associated Methicillin-Resistant Staphylococcus aureus Biofilms by Time-Kill Assays Qun Yan, Melissa J. Karau, Yash S. Raval, Robin Patel Shlaes T Lysostaphin Lysibody Leads to Effective Opsonization and Killing of Methicillin- e01056-18 Experimental Resistant Staphylococcus aureus in a Murine Model Assaf Raz, Anna Serrano, Maneesha Thaker, Tricia Alston, Vincent A. Fischetti

CLINICAL THERAPEUTICS Silverman T Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection e00163-18 Clinical Empirical Antimicrobial Therapy Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig, Michel-Henry Fessy, Christian Chidiac, Tristan Ferry, on behalf of the Lyon BJI Study Group Arikan-Akdagli T A Prospective Real-World Study of the Impact of an Antifungal Stewardship e00402-18 Clinical Program in a Tertiary Respiratory-Medicine Setting Lisa Nwankwo, Jimstan Periselneris, Jamie Cheong, Keith Thompson, Peter Darby, Neil Leaver, Silke Schelenz, Darius Armstrong-James Dooley T In Vitro MIC Values of Rifampin and Ethambutol and Treatment Outcome in e00491-18 Clinical Mycobacterium avium Complex Lung Disease Byoung Soo Kwon, Mi-Na Kim, Heungsup Sung, Younsuck Koh, Woo-Sung Kim, Jin-Woo Song, Yeon-Mok Oh, Sang-Do Lee, Sei Won Lee, Jae-Seung Lee, Chae-Man Lim, Chang-Min Choi, Jin-Won Huh, Sang-Bum Hong, Sojung Park, Tae Sun Shim, Yong Pil Chong, Kyung-Wook Jo

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Leggett T Single-Center Pharmacokinetic Study and Simulation of a Low Meropenem e00542-18 Clinical Concentration in Brain-Dead Organ Donors Jae-Myeong Lee, Joo Won Lee, Tae Seok Jeong, Eun Sook Bang, So Hee Kim Boucher T Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus e00731-18 Clinical aureus Infection Nak-Hyun Kim, Wan Beom Park, Jeong Eun Cho, Yoon Jeong Choi, Su Jin Choi, Soo Youn Jun, Chang Kyung Kang, Kyoung-Ho Song, Pyoeng Gyun Choe, Ji-Hwan Bang, Eu Suk Kim, Sang Won Park, Nam-Joong Kim, Myoung-don Oh, Hong Bin Kim Andes T Population Pharmacokinetic Analyses for Ertapenem in Subjects with a Wide e00784-18 Clinical Range of Body Sizes Elizabeth A. Lakota, Cornelia B. Landersdorfer, Li Zhang, Anne N. Nafziger, Joseph S. Bertino, Jr., Sujata M. Bhavnani, Alan Forrest Andes T Clinical Outcomes of Oral Suspension versus Delayed-Release Tablet e00893-18 Clinical Formulations of Posaconazole for Prophylaxis of Invasive Fungal Infections Jon P. Furuno, Gregory B. Tallman, Brie N. Noble, Joseph S. Bubalo, Graeme N. Forrest, James S. Lewis II, Ana F. Bienvenida, Courtney A. Holmes, Bo R. Weber, Jessina C. McGregor Dooley T Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with e01105-18 Clinical Mycobacterium avium Complex and Mycobacterium abscessus Complex Sun Hye Shin, Byung Woo Jhun, Su-Young Kim, Junsu Choe, Kyeongman Jeon, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Won-Jung Koh

PHARMACOLOGY Andes T Pharmacodynamics of Daptomycin against Enterococcus faecium and e00506-18 Pharmacology Enterococcus faecalis in the Murine Thigh Infection Model James M. Kidd, Kamilia Abdelraouf, Tomefa E. Asempa, Romney M. Humphries, David P. Nicolau Andes T Population Pharmacokinetics of Artemether, Dihydroartemisinin, and e00518-18 Pharmacology Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria Jesmin Lohy Das, Stephen Rulisa, Peter J. de Vries, Petra F. Mens, Nadine Kaligirwa, Steven Agaba, Joel Tarning, Mats O. Karlsson, Thomas P. C. Dorlo Chambers S Impact of Antibiotic Treatment on the Burden of Nasal Staphylococcus aureus e00609-18 Pharmacology among Hospitalized Patients Anubhav Kanwar, Jennifer L. Cadnum, Annette L. Jencson, Curtis J. Donskey Milhous T Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable e00631-18 Pharmacology Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B Gert-Jan Wijnant, Katrien Van Bocxlaer, Amanda Fortes Francisco, Vanessa Yardley, Andy Harris, Mo Alavijeh, Sudaxshina Murdan, Simon L. Croft Dooley T Structure-Based Drug Design and Characterization of Sulfonyl-Piperazine e00681-18 Pharmacology Benzothiazinone Inhibitors of DprE1 from Mycobacterium tuberculosis Jérémie Piton, Anthony Vocat, Andréanne Lupien, Caroline S. Foo, Olga Riabova, Vadim Makarov, Stewart T. Cole

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Dooley S Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of e00770-18 Pharmacology Tuberculosis Charles A. Peloquin, Patrick P. J. Phillips, Carole D. Mitnick, Kathleen Eisenach, Ramonde F. Patientia, Leonid Lecca, Eduardo Gotuzzo, Neel R. Gandhi, Donna Butler, Andreas H. Diacon, Bruno Martel, Juan Santillan, Kathleen Robergeau Hunt, Dante Vargas, Florian von Groote-Bidlingmaier, Carlos Seas, Nancy Dianis, Antonio Moreno-Martinez, Pawandeep Kaur, C. Robert Horsburgh, Jr. Leggett T Population Pharmacokinetics of Amikacin in Adult Patients with Cystic Fibrosis e00877-18 Pharmacology Sílvia M. Illamola, Hoa Q. Huynh, Xiaoxi Liu, Zubin N. Bhakta, Catherine M. Sherwin, Theodore G. Liou, Holly Carveth, David C. Young Leggett T Validation of a Dried Blood Spot Ceftriaxone Assay in Papua New Guinean e00940-18 Pharmacology Children with Severe Bacterial Infections Mispah Mukap, Corin Sprod, Nakapi Tefuarani, Moses Laman, Madhu Page-Sharp, Sam Salman, Brioni R. Moore, Kevin T. Batty, Timothy M. E. Davis, Laurens Manning Andes S Validation of Heel Stick Microsampling To Optimize Micafungin Doses in e01199-18 Pharmacology Neonates and Young Infants Cinzia Auriti, Bianca Maria Goffredo, Maria Paola Ronchetti, Fiammetta Piersigilli, Sara Cairoli, Iliana Bersani, Andrea Dotta, Manjunath P. Pai Andes T Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and e01228-18 Pharmacology Muscle of Rats with or without Experimental Peritonitis Alexia Chauzy, Isabelle Lamarche, Christophe Adier, William Couet, Sandrine Marchand Leggett T Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and e01252-18 Pharmacology Lumefantrine in HIV-Malaria Coinfection Adebanjo Adegbola, Rana Abutaima, Adeniyi Olagunju, Omotade Ijarotimi, Marco Siccardi, Andrew Owen, Julius Soyinka, Oluseye Bolaji Andes S Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: e01261-18 Pharmacology 6. Aminoglycosides Sandrine Marchand, Matthieu Boisson, Shachi Mehta, Christophe Adier, Olivier Mimoz, Nicolas Grégoire, William Couet Andes T Ex Vivo Characterization of Effects of Renal Replacement Therapy Modalities and e01306-18 Pharmacology Settings on Pharmacokinetics of Meropenem and Vaborbactam Fekade B. Sime, Saurabh Pandey, Nermin Karamujic, Suzanne Parker, Elizabeth Alexander, Jeffery Loutit, Stephanie Durso, David Griffith, Jeffrey Lipman, Steven C. Wallis, Jason A. Roberts Milhous T Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis e02193-17 Pharmacology To Optimize Dosing Ali Mohamed Ali, Melissa A. Penny, Thomas A. Smith, Lesley Workman, Philip Sasi, George O. Adjei, Francesca Aweeka, Jean-René Kiechel, Vincent Jullien, Marcus J. Rijken, Rose McGready, Julia Mwesigwa, Kim Kristensen, Kasia Stepniewska, Joel Tarning, Karen I. Barnes, Paolo Denti, for the WWARN Amodiaquine PK Study Group

LETTERS TO THE EDITOR Helen Boucher L Is Alternate-Day Therapeutic Drug Monitoring in the Intensive Care Unit Not e01209-18 Letter Intensive Enough? Parviz Sorooshian, Timothy A. C. Snow

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Helen Boucher L Reply to Sorooshian and Snow, “Is Alternate-Day Therapeutic Drug Monitoring in e01343-18 Letter the Intensive Care Unit Not Intensive Enough?” A. Fournier, P. Eggimann, O. Pantet, J. L. Pagani, E. Dupuis-Lozeron, A. Pannatier, F. Sadeghipour, P. Voirol, Y.-A. Que

ERRATUM Louis B. Rice X Erratum for Yew et al., “Oxidative Stress and First-Line Antituberculosis e01633-18 Erratum Drug-Induced Hepatotoxicity” Wing Wai Yew, Kwok Chiu Chang, Denise P. Chan

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