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Neutropenia Fact Sheet
Neutropenia in Barth Syndrome i ii (Chronic, Cyclic or Intermittent) What problems can Neutropenia cause? Neutrophils are the main white blood cell for fighting or preventing bacterial or fungal infections. They may be referred to as polymorphonuclear cells (polys or PMNs), white cells with segmented nuclei (segs), or neutrophils in the complete blood cell count (CBC) report. Immature neutrophils are referred to as bands. When someone is neutropenic (an abnormally low level of neutrophils in the blood), the risk of infection increases. The absolute neutrophil count (ANC) is a measure of the total number of neutrophils present in the blood. When the ANC is less than 1,000, the risk of infection increases. Most infections occur in the ears, skin or throat and to a lesser extent, the chest. These infections can be very serious and may require antibiotics to clear infections. When someone with Barth syndrome is neutropenic his defenses are weakened, he is likely to become seriously ill more quickly than someone with a normal neutrophil count. Tips: • No rectal temperatures as any break in the skin can lead to an infection. • If the individual has a temperature > 100.4° F (38° C) or has infectious symptoms, the primary physician or hematologist should be notified. The individual may need to be seen. • If the individual has a temperature of 100.4° F (38° C) – 100.5° F (38.05° C)> 8 hours or a temperature > 101.5° F (38.61° C), an immediate examination by the physician is warranted. Some or all of the following studies may be ordered: CBC with differential and ANC Urinalysis Blood, urine, and other appropriate cultures C-Reactive Protein Echocardiogram if warranted • The physician may suggest antibiotics (and G-CSF if the ANC is low) for common infections such as otitis media, stomatitis. -
Anterior Reconstruction Techniques for Cervical Spine Deformity
Neurospine 2020;17(3):534-542. Neurospine https://doi.org/10.14245/ns.2040380.190 pISSN 2586-6583 eISSN 2586-6591 Review Article Anterior Reconstruction Techniques Corresponding Author for Cervical Spine Deformity Samuel K. Cho 1,2 1 1 1 https://orcid.org/0000-0001-7511-2486 Murray Echt , Christopher Mikhail , Steven J. Girdler , Samuel K. Cho 1Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA Department of Orthopaedics, Icahn 2 Department of Neurological Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, School of Medicine at Mount Sinai, 425 NY, USA West 59th Street, 5th Floor, New York, NY, USA E-mail: [email protected] Cervical spine deformity is an uncommon yet severely debilitating condition marked by its heterogeneity. Anterior reconstruction techniques represent a familiar approach with a range Received: June 24, 2020 of invasiveness and correction potential—including global or focal realignment in the sagit- Revised: August 5, 2020 tal and coronal planes. Meticulous preoperative planning is required to improve or prevent Accepted: August 17, 2020 neurologic deterioration and obtain satisfactory global spinal harmony. The ability to per- form anterior only reconstruction requires mobility of the opposite column to achieve cor- rection, unless a combined approach is planned. Anterior cervical discectomy and fusion has limited focal correction, but when applied over multiple levels there is a cumulative ef- fect with a correction of approximately 6° per level. Partial or complete corpectomy has the ability to correct sagittal deformity as well as decompress the spinal canal when there is an- terior compression behind the vertebral body. -
Management of Rapidly Progressing Periodontitis: an Overview
Review Article Management of Rapidly Progressing Periodontitis: An Overview Sadat SMA1, Chowdhury NM2, Baten RBA3 Abstract causes rapid destruction of periodontal ligament and History of periodontal diseases recognition and alveolar bone which occurs in otherwise systemically treatment is ancient for at least 5000 years. There are healthy individuals generally of a younger age group but 1,8 different presentations of periodontal diseases. Rapidly patients may be older . A familial aggregation of the 9 progression periodontitis or aggressive periodontitis disease is also noted . It includes both localized and causes rapid destruction of the periodontium which leads generalized forms. It was previously known as early onset to early tooth loss. It may be generalized or localized. periodontitis that included three categories of periodontitis Periodontitis may be treated surgically or non-surgically - Pubertal, Juvenile and rapidly progressing but patients with rapidly progressing periodontitis do not periodontitis10,11. Early diagnosis and appropriate respond predictably to conventional therapy due to its treatment is necessary to prevent early tooth loss. multi factorial etiology. Successful management of the disease is difficult if not diagnosed early and treated Classification appropriately. Regenerative therapy, tissue engineering Classification of diseases helps the clinicians to develop a and genetic technologies are the new hope for the structure which can be used to identify diseases in relation treatment of rapidly progressing periodontitis. -
2019 Spine Coding Basics
2019 Spine Coding Basics Presenter: Kerri Larson, CPC Directory of Coding and Audit Services 2019 Spine Surgery 01 Spine Surgery Terminology & Anatomy 02 Spine Procedures 03 Case Study 04 Diagnosis 05 Q & A Spine Surgery Terminology & Anatomy Spine Surgery Terminology & Anatomy Term Definition Arthrodesis Fusion, or permanent joining, of a joint, or point of union of two musculoskeletal structures, such as two bones Surgical procedure that replaces missing bone with material from the patient's own body, or from an artificial, synthetic, or Bone grafting natural substitute Corpectomy Surgical excision of the main body of a vertebra, one of the interlocking bones of the back. Cerebrospinal The protective body fluid present in the dura, the membrane covering the brain and spinal cord fluid or CSF Decompression A procedure to remove pressure on a structure. Diskectomy, Surgical removal of all or a part of an intervertebral disc. discectomy Dura Outermost of the three layers that surround the brain and spinal cord. Electrode array Device that contains multiple plates or electrodes. Electronic pulse A device that produces low voltage electrical pulses, with a regular or intermittent waveform, that creates a mild tingling or generator or massaging sensation that stimulates the nerve pathways neurostimulator Spine Surgery Terminology & Anatomy Term Definition The space that surrounds the dura, which is the outermost layer of membrane that surrounds the spinal canal. The epidural space houses the Epidural space spinal nerve roots, blood and lymphatic vessels, and fatty tissues . Present inside the skull but outside the dura mater, which is the thick, outermost membrane covering the brain or within the spine but outside Extradural the dural sac enclosing the spinal cord, nerve roots and spinal fluid. -
Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters
microorganisms Article Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters Andrea Butera , Simone Gallo * , Carolina Maiorani, Domenico Molino, Alessandro Chiesa, Camilla Preda, Francesca Esposito and Andrea Scribante * Section of Dentistry–Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, 27100 Pavia, Italy; [email protected] (A.B.); [email protected] (C.M.); [email protected] (D.M.); [email protected] (A.C.); [email protected] (C.P.); [email protected] (F.E.) * Correspondence: [email protected] (S.G.); [email protected] (A.S.) Abstract: Periodontitis consists of a progressive destruction of tooth-supporting tissues. Considering that probiotics are being proposed as a support to the gold standard treatment Scaling-and-Root- Planing (SRP), this study aims to assess two new formulations (toothpaste and chewing-gum). 60 patients were randomly assigned to three domiciliary hygiene treatments: Group 1 (SRP + chlorhexidine-based toothpaste) (control), Group 2 (SRP + probiotics-based toothpaste) and Group 3 (SRP + probiotics-based toothpaste + probiotics-based chewing-gum). At baseline (T0) and after 3 and 6 months (T1–T2), periodontal clinical parameters were recorded, along with microbiological ones by means of a commercial kit. As to the former, no significant differences were shown at T1 or T2, neither in controls for any index, nor in the experimental -
THE PATHOLOGY of BONE MARROW FAILURE Roos Leguit, Jan G Van Den Tweel
THE PATHOLOGY OF BONE MARROW FAILURE Roos Leguit, Jan G van den Tweel To cite this version: Roos Leguit, Jan G van den Tweel. THE PATHOLOGY OF BONE MARROW FAILURE. Histopathology, Wiley, 2010, 57 (5), pp.655. 10.1111/j.1365-2559.2010.03612.x. hal-00599534 HAL Id: hal-00599534 https://hal.archives-ouvertes.fr/hal-00599534 Submitted on 10 Jun 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Histopathology THE PATHOLOGY OF BONE MARROW FAILURE ForJournal: Histopathology Peer Review Manuscript ID: HISTOP-02-10-0090 Manuscript Type: Review Date Submitted by the 08-Feb-2010 Author: Complete List of Authors: Leguit, Roos; UMC utrecht, Pathology van den Tweel, Jan; UMC Utrecht, Pathology bone marrow, histopathology, myelodysplastic syndromes, Keywords: inherited bone marrow failure syndromes, trephine biopsy Published on behalf of the British Division of the International Academy of Pathology Page 1 of 40 Histopathology THE PATHOLOGY OF BONE MARROW FAILURE Roos J Leguit & Jan G van den Tweel University Medical Centre Utrecht Department of Pathology H4.312 Heidelberglaan 100 For Peer Review 3584 CX Utrecht The Netherlands Running title: Pathology of bone marrow failure Keywords: bone marrow, histopathology, myelodysplastic syndromes, inherited bone marrow failure syndromes, trephine biopsy. -
Two-Level Cervical Corpectomy—Long-Term Follow-Up Reveals the High Rate of Material Failure in Patients, Who Received an Anterior Approach Only
Neurosurgical Review (2019) 42:511–518 https://doi.org/10.1007/s10143-018-0993-6 ORIGINAL ARTICLE Two-level cervical corpectomy—long-term follow-up reveals the high rate of material failure in patients, who received an anterior approach only Simon Heinrich Bayerl1 & Florian Pöhlmann1 & Tobias Finger1 & Vincent Prinz1 & Peter Vajkoczy 1 Received: 25 August 2017 /Revised: 20 November 2017 /Accepted: 5 December 2017 /Published online: 18 June 2018 # Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract In contrast to a one-level cervical corpectomy, a multilevel corpectomy without posterior fusion is accompanied by a high material failure rate. So far, the adequate surgical technique for patients, who receive a two-level corpectomy, remains to be elucidated. The aim of this study was to determine the long-term clinical outcome of patients with cervical myelopathy, who underwent a two-level corpectomy. Outcome parameters of 21 patients, who received a two-level cervical corpectomy, were retrospectively analyzed concerning reoperations and outcome scores (VAS, Neck Disability Index (NDI), Nurick scale, mod- ified Japanese Orthopaedic Association score (mJOAS), Short Form 36-item Health Survey Questionnaire (SF-36)). The failure rate was determined using postoperative radiographs. The choice over the surgical procedures was exercised by every surgeon individually. Therefore, a distinction between two groups was possible: (1) anterior group (ANT group) with a two-level corpectomy and a cervical plate, (2) anterior/posterior group (A/P group) with two-level corpectomy, cervical plate, and addi- tional posterior fusion. Both groups benefitted from surgery concerning pain, disability, and myelopathy. While all patients of the A/P group showed no postoperative instability, one third of the patients of the ANT group exhibited instability and clinical deterioration. -
Pediatric Oral Pathology. Soft Tissue and Periodontal Conditions
PEDIATRIC ORAL HEALTH 0031-3955100 $15.00 + .OO PEDIATRIC ORAL PATHOLOGY Soft Tissue and Periodontal Conditions Jayne E. Delaney, DDS, MSD, and Martha Ann Keels, DDS, PhD Parents often are concerned with “lumps and bumps” that appear in the mouths of children. Pediatricians should be able to distinguish the normal clinical appearance of the intraoral tissues in children from gingivitis, periodontal abnormalities, and oral lesions. Recognizing early primary tooth mobility or early primary tooth loss is critical because these dental findings may be indicative of a severe underlying medical illness. Diagnostic criteria and .treatment recommendations are reviewed for many commonly encountered oral conditions. INTRAORAL SOFT-TISSUE ABNORMALITIES Congenital Lesions Ankyloglossia Ankyloglossia, or “tongue-tied,” is a common congenital condition characterized by an abnormally short lingual frenum and the inability to extend the tongue. The frenum may lengthen with growth to produce normal function. If the extent of the ankyloglossia is severe, speech may be affected, mandating speech therapy or surgical correction. If a child is able to extend his or her tongue sufficiently far to moisten the lower lip, then a frenectomy usually is not indicated (Fig. 1). From Private Practice, Waldorf, Maryland (JED); and Department of Pediatrics, Division of Pediatric Dentistry, Duke Children’s Hospital, Duke University Medical Center, Durham, North Carolina (MAK) ~~ ~ ~ ~ ~ ~ ~ PEDIATRIC CLINICS OF NORTH AMERICA VOLUME 47 * NUMBER 5 OCTOBER 2000 1125 1126 DELANEY & KEELS Figure 1. A, Short lingual frenum in a 4-year-old child. B, Child demonstrating the ability to lick his lower lip. Developmental Lesions Geographic Tongue Benign migratory glossitis, or geographic tongue, is a common finding during routine clinical examination of children. -
• Cytosis: O Neutrophilia: Defined As an Increase in the Neutrophilic Count in the Peripheral Blood Above Reference Range for Age
HENATOLYMPHOID SYSTEM THIRD YEAR MEDICAL STUDENTS-UNIVERSITY OF JORDAN AHMAD T. MANSOUR, MD NONNEOPLASTIC DISEASES OF THE WHITE BLOOD CELLS • There are five major types of WBCs in the blood: neutrophils, lymphocytes, eosinophils, basophils and monocytes. • The normal function of the white blood cells depends on a tight regulation of their count and their function. Therefore, disease develops if there is a derangement of the cells count or function, it takes one of the following forms: o Cytosis: increase in the number of circulating cells above reference range. (Note: leukocytosis means an increase in the WBC count, neutrophilia means increase in the neutrophilic count, lymphocytosis means increase in the lymphocytic count, monocytosis means increase in the monocytic count, basophilia means increase in the basophilic count and eosinophilia means in crease in the eosinophilic count). o Cytopenia: decrease in the number of circulating cells below reference range. (Note: neutropenia means decreased neutrophils, lymphocytopenia, or simply lymphopenia, means decrease in lymphocytes, monocytopenia means decrease in monocytes, eosinopenia means decrease in eosinophils, and basopenia means decrease in basophils). o Abnormal or absent function • Cytosis: o Neutrophilia: defined as an increase in the neutrophilic count in the peripheral blood above reference range for age. o Causes: bacterial infection is the most common and most important etiology. Tissue necrosis in cases of burns or trauma and medications such as epinephrine and corticosteroids are also additional causes for neutrophilia. § Some physiologic conditions can lead to neutrophilia such as stress, smoking and pregnancy. o Pathophysiology: neutrophils are present in the blood in two populations: circulating and marginal (meaning neutrophils stuck to the vessel wall). -
Adverse Effects of Mouth Breathing
AGD - Academy of General Denstry hp://www.agd.org/publicaons/arcles/?ArtID=6850 Mouth breathing: Adverse effects on facial growth, health, Contact Us academics, and behavior Send to a Friend By Yosh Jefferson, DMD, MAGD Send to Printer Featured in General Dentistry , January/February 2010 Pg. 18-25 Close Window Posted on Friday, January 08, 2010 The vast majority of health care professionals are unaware of the negative impact of upper airway obstruction (mouth breathing) on normal facial growth and physiologic health. Children whose mouth breathing is untreated may develop long, narrow faces, narrow mouths, high palatal vaults, dental malocclusion, gummy smiles, and many other unattractive facial features, such as skeletal Class II or Class III facial profiles. These children do not sleep well at night due to obstructed airways; this lack of sleep can adversely affect their growth and academic performance. Many of these children are misdiagnosed with attention deficit disorder (ADD) and hyperactivity. It is important for the entire health care community (including general and pediatric dentists) to screen and diagnose for mouth breathing in adults and in children as young as 5 years of age. If mouth breathing is treated early, its negative effect on facial and dental development and the medical and social problems associated with it can be reduced or averted. Received: February 11, 2009 Accepted: May 5, 2009 The importance of facial appearances in contemporary society is undeniable. Many studies have shown that individuals with attractive facial features are more readily accepted than those with unattractive facial features, providing them with significant advantages. 1-6 However, many health care professionals (as well as the public) feel that individual facial features are the result of genetics and therefore cannot be altered or changed—in other words, the genotype ultimately controls the phenotype. -
Association Between Oral Habits, Mouth Breathing And
Association between oral habits, mouth breathing E.G. Paolantonio, N. Ludovici, and malocclusion in Italian S. Saccomanno, G. La Torre*, C. Grippaudo preschoolers Dental and Maxillofacial Institute, Head and Neck Department, Fondazione Policlinico Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy *Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy e-mail: [email protected] DOI 10.23804/ejpd.2019.20.03.07 Abstract Introduction Etiopathogenesis of malocclusion involves not only genetic Aim This cross-sectional study was carried out to evaluate but also environmental factors, since craniofacial development the prevalence of malocclusion and associated factors in is stimulated by functional activities such as breathing, preschoolers with the aim of assessing the existence of an chewing, sucking and swallowing [Salone et al., 2013]. association between bad habits and mouth breathing with Non-nutritive sucking habits and mouth breathing are the the most severe malocclusions. most significant environmental risk factors for malocclusion Materials and methods A sample of 1616 children aged [Grippaudo et al., 2016; Gòis et al., 2008; Primoži et al., 2013], 3–6 years was visited by applying the Baby ROMA index, an as they can interfere with occlusion and normal craniofacial orthodontic treatment need index for preschool age. The development. Infants have an inherent, biological drive following were searched: the prevalence of malocclusion, for sucking, that can be satisfied through nutritive sucking, the association of bad habits and mouth breathing with including breast- and bottle-feeding, or through non-nutritive malocclusion, how often are found in association and how sucking on objects such as digits, pacifiers, or toys that may this association is statistically significant. -
Chronic Suppuration in the Nasal Accessory Sinuses and Its Treatment
Hospital Clinics. CHRONIC SUPPURATION IN THE NASAL ACCESSORY SINUSES AND ITS TREATMENT. Two Lectures by "YVm. J. Chichele-Noukse, F.R.C.S.(Edin.), Surgeon to the Central London Throat, Nose, and Ear Hospital; late President of the British Laryngological, Rhinological, and Oto- logical Association. the These lectures were specially reported for during one of the specific fevers, such as typhoid,, columns of The Hospital to illustrate the nature scarlatina, or (especially) influenza. Chronic of the graduate teaching given at this important sinusitis, either the sequel of an unhealed acute been special centre. The notes have very kindly catarrh or, possibly, originating de novo. revised by the lecturer. Simple Empyema: Cystic disease or mucocele, and and tumours. Besides The Grouping of the Sinuses. benign malignant these, the sinuses are liable to be invaded by malig- For clinical purposes, the accessory sinuses of the nant disease or by gummata arising in neighbour- nose may be divided into two groups, according to ing parts, or their bony walls may become necrosed the position of their ostia. The maxillary antrum, or carious. the frontal sinus, and the anterior ethmoidal cells, Chronic Sinusitis. meatus having their ostia opening into the middle The key to the study of diseases of the sinuses is. of the form an anterior The nose, group. chronic sinusitis. To this part of the subject, there- sinus and the ethmoidal sphenoidal posterior cells, fore, as the time is limited, it is proposed to confine opening into the superior meatus, form a posterior the following observations: group. In chronic sinusitis the becomes In each muco-periosteum group the ostia lie very close together.