Studies on Phenolic Steroids in Human Subjects. VII. Metabolic Fate of Estriol and Its Glucuronide
Studies on Phenolic Steroids in Human Subjects. VII. Metabolic Fate of Estriol and Its Glucuronide Avery A. Sandberg, W. Roy Slaunwhite Jr. J Clin Invest. 1965;44(4):694-702. https://doi.org/10.1172/JCI105181. Research Article Find the latest version: https://jci.me/105181/pdf Journal of Clinical Investigation Vol. 44, No. 4, 1965 Studies on Phenolic Steroids in Human Subjects. VII. Metabolic Fate of Estriol and Its Glucuronide * AVERY A. SANDBERG t AND W. RoY SLAUNWHITE, JR. (From the Roswell Park Memorial Institute, Buffalo, N. Y.) Estriol has been considered a metabolic product of enzymes capable of oxidizing the hydroxyl of the more active estrogens, estrone (1, 2) and group at position 16, a finding not reported in the indirectly estradiol. Recently, an alternative path- past. way has been proposed (3) based on the observa- The attention of investigators has recently been tions that 16a-hydroxydehydroepiandrosterone is directed toward steroid conjugates, not only be- present in high concentrations in cord blood and cause they are excreted in that form, but owing to that it is aromatized by placental enzymes. During the demonstration that steroid sulfates may, in pregnancy the placenta has been thought the some instances, serve as biosynthetic intermediates source of the mother's urinary estriol, but recent (12-14), that dehydroepiandrosterone sulfate is evidence indicates that the fetus (4-6) and, in par- secreted by the adrenal cortex (15), that estrone ticular, the fetal liver (7) may play an important circulates in the blood as a sulfate (16), and that role in the conversion of the estrone to estriol steroid sulfates appear to be biologically active (8).
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