Table E-46. Therapies Used in Trials Comparing Hormone with Placebo Ar Est Study N Rxcat Dose Route Generic Trade M Dose Martin 1971 1 56 Plac Oral

Home , Bazedoxifene, Conjugated estrogens, Equine estrogen, Estradiol acetate, Estriol (medication), Mestranol

Table E-46. Therapies used in trials comparing hormone with placebo Ar Est Study N RxCat Dose Route Generic Trade m Dose Martin 1971 1 56 Plac Oral

Standar 2 53 EP seq 0.025 mg E + 1 mg P Oral mestranol + norethindrone d 3 56 EP seq 0.05 mg E + 1 mg P Oral mestranol + norethindrone High Campbell 1 68 Plac Oral 1977 2 68 Est 1.25 mg Oral conjugated equine estrogens Premarin High Baumgardner 1 42 Plac Oral 1978 2 42 Est 0.1 mg Oral quinestrol Estrovis Low Standar 3 35 Est 0.2 mg Oral quinestrol Estrovis d 4 37 Est 1.25 mg Oral conjugated estrogen Premarin High

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Coope 1981 1 26 Plac Oral

UltraLo 2 29 Est 0.3mg Oral piperazine estrone sulphate w Jensen 1983 1 90 Plac Oral

estradiol + estriol + 2 41 EP seq 4 mg E + 1 mg P Oral Trisequens Forte High norethisterone acetate Foidart 1991 1 53 Plac VagPes

Ortho-Gynest- 2 56 Est 1 mg VagPes estriol Low Depot Eriksen 1992 1 79 Plac VagTab

2 75 Est 0.025 mg VagTab estradiol Vagifem Low Wiklund 1993 11 1 Plac Patch 1 11 Standar 2 Est 0.05 mg Patch estradiol 2 d Derman 1995 1 42 Plac Oral

Standar 2 40 EP seq 2 mg E + 1 mg P Oral estradiol + norethindrone acetate Trisequens d Saletu 1995 1 32 Plac Patch

Standar 2 32 Est 0.05 mg Patch estradiol Estraderm d Good 1996 1 91 Plac Patch

Standar 2 88 Est 0.05 mg Patch estradiol Alora d 3 94 Est 0.10 mg Patch estradiol Alora High Speroff (Study 1) 1 54 Plac Patch

1996 UltraLo 2 54 Est 0.02 mg Patch estradiol FemPatch w

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Chung 1996 1 40 Plac Oral

Standar 2 43 Est 2mg Oral estradiol Estrofem d Speroff (Study 2) 1 37 Plac Patch

1996 UltraLo 2 37 Est 0.02 mg Patch estradiol FemPatch w 3 37 Est 0.04 mg Patch estradiol FemPatch Low Speroff (Study 3) 1 53 Plac Patch

1996 2 53 Est 0.04 mg Patch estradiol FemPatch Low Bacchi- 1 56 Plac Patch Modena 1997 Standar 2 53 Est 0.05 mg Patch estradiol Estraderm MX d Baerug 1998 1 41 Plac Oral

EP 2 38 1mg E + 0.25mg P Oral estradiol + norethisterone acetate Activelle Low comb EP 3 40 1mg E + 0.5mg P Oral estradiol + norethisterone acetate Activelle Low comb Bech 1998 1 51 Plac Oral

EP Standar 2 50 2 mg E + 1 mg P Oral estradiol + norethisterone acetate Kliogest comb d Trisekvens (also Standar 3 50 EP seq 2 mg E + 1 mg P Oral estradiol + norethisterone acetate Trisequens) d de Vrijer 1999 1 86 Plac Patch

Standar 2 82 Est 0.05 mg Patch estradiol Estraderm MX 50 d

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Estraderm MX 3 86 Est 0.10 mg Patch estradiol High 100 Leonetti 1999 SknCr 1 47 Plac m SknCr 2 43 Prog 20 mg progesterone m Studd 1999 1 60 Plac NasSpr

Aerodiol + EP estradiol + medroxyprogesterone 2 58 0.1mg E + 5mg P NasSpr medroxyprogeste Low comb acetate rone acetate Aerodiol + EP estradiol + medroxyprogesterone 3 62 0.20mg E + 5mg P NasSpr medroxyprogeste Low comb acetate rone acetate Aerodiol + EP estradiol + medroxyprogesterone Standar 4 54 0.30mg E + 5mg P NasSpr medroxyprogeste comb acetate d rone acetate Aerodiol + EP estradiol + medroxyprogesterone 5 62 0.40mg E + 5mg P NasSpr medroxyprogeste High comb acetate rone acetate Polo-Kantola 1 32 Plac SknGel 1999 Estrogel or Standar 2 30 Est SknGel estradiol Evorel d Casper 1999 1 34 Plac VayRin

2 33 Est 0.0075 mg VayRin estradiol Estring Low Cohen 1999 12 1 Plac Patch 9 13 2 Est 0.0375mg Patch estradiol Vivelle Low 0 Rebar 2000 1 10 Plac Oral

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Ar Est Study N RxCat Dose Route Generic Trade m Dose 3 10 2 Est 0.3 mg Oral esterified estrogen Estratab Low 1 Speroff (Study 1) 1 43 Plac Oral

2000 EP 0.001 mg EE + 0.2 ethinyl estradiol (EE) + UltraLo 2 45 Oral FemHRT comb mg NA norethindrone acetate (NA) w EP 0.0025 mg EE + 0.5 ethinyl estradiol (EE) + 3 41 Oral FemHRT Low comb mg NA norethindrone acetate (NA) EP 0.005 mg EE + 1 mg ethinyl estradiol (EE) + 4 45 Oral FemHRT Low comb NA norethindrone acetate (NA) EP 0.010 mg EE + 1 mg ethinyl estradiol (EE) + Standar 5 45 Oral FemHRT comb NA norethindrone acetate (NA) d Rovati 2000 1 80 Plac Patch

UltraLo 2 80 Est 0.025 mg Patch estradiol Dermestril w Standar 3 77 Est 0.05 mg Patch estradiol Dermestril d Standar 4 74 Est 0.05 mg Patch estradiol Dermestril d Notelovitz 1 49 Plac Oral 2000 2 48 Est 1 mg Oral estradiol Low

UltraLo 3 48 Est 0.5 mg Oral estradiol w Strickler 2000 10 1 Plac Oral 5 Standar 2 96 Est 0.625 mg Oral conjugated equine estrogens d

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Notelovitz 1 66 Plac Oral 2000 UltraLo 2 68 Est 0.25 mg Oral estradiol w UltraLo 3 64 Est 0.5 mg Oral estradiol w 4 67 Est 1.0 mg Oral estradiol Low

Standar 5 68 Est 2.0 mg Oral estradiol d DeAloysio 1 52 Plac Patch 2000 UltraLo 2 52 Est 0.025 mg Patch estradiol Dermestril w 3 52 Est 0.0375 mg Patch estradiol Dermestril Low von Holst 1 93 Plac Patch 2000 Standar 2 93 Est 0.05 mg Patch estradiol Fem7 d Notelovitz 1 53 Plac Patch 2000 estradiol+ estradiol/norethindrone Vivelle + Standar 2 54 EP seq 0.050mg + 0.140mg Patch acetate CombiPatch d 0.050mg E + estradiol+ estradiol/norethindrone Vivelle + Standar 3 59 EP seq Patch 0.250mg P acetate CombiPatch d 0.050mg E + estradiol+ estradiol/norethindrone Vivelle + Standar 4 53 EP seq Patch 0.400mg P acetate CombiPatch d Alexandersen 1 50 Plac Oral 2000 0.75mg E + 0.35mg 2 50 EP seq Oral piperazine estrone sulphate + norethisterone Low P

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Standar 3 50 EP seq 1.5mg E + 0.7mg P Oral piperazine estrone sulphate + norethisterone d EP Standar 4 50 2mg E + 1mg P Oral estradiol + norethisterone acetate comb d Speroff (Study 2) 1 67 Plac Oral

2000 EP 0.0025 mg EE + 0.5 ethinyl estradiol (EE) + 2 67 Oral FemHRT Low comb mg NA norethindrone acetate (NA) EP 0.005 mg EE + 1 mg ethinyl estradiol (EE) + 3 67 Oral FemHRT Low comb NA norethindrone acetate (NA) EP 0.010 mg EE + 1 mg ethinyl estradiol (EE) + Standar 4 65 Oral FemHRT comb NA norethindrone acetate (NA) d Rigano 2001 19 1 Plac 1 17 Standar 2 Est 0.05 mg Patch estradiol Dermestril 1 d Utian (CEE alone arms) 1 28 Plac Oral

2001 UltraLo 2 30 Est 0.3mg Oral conjugated equine estrogen w 3 32 Est 0.45mg Oral conjugated equine estrogen Low Standar 4 27 Est 0.625mg Oral conjugated equine estrogen d Simon 2001 1 48 Plac Oral

Standar 2 72 Est 0.625 mg Oral synthetic conjugated estrogen-A Cenestin d Soares 2001 1 25 Plac Patch

2 25 Est 0.1 mg Patch estradiol Systen/Evorel High

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Utian (CEE/MPA 1 28 Plac Oral arms) 2001 EP conjugated equine estrogen + medroxyprogesterone UltraLo 2 33 0.3mg E + 1.5mg P Oral comb acetate w EP conjugated equine estrogen + medroxyprogesterone 3 29 0.45mg E + 1.5mg P Oral Low comb acetate EP conjugated equine estrogen + medroxyprogesterone 4 28 0.45mg E + 2.5mg P Oral Low comb acetate EP 0.625mg E + 2.5mg conjugated equine estrogen + medroxyprogesterone Standar 5 34 Oral comb P acetate d Rozenbaum 1 57 Plac NasSpr 2002 2 54 Est 0.15 mg NasSpr estradiol Aerodiol Low Standar 3 54 Est 0.30 mg NasSpr estradiol Aerodiol d Shulman (Study 1) 1 93 Plac Patch

2002 EP 0.045 mg E + 0.030 2 96 Patch estradiol + levonorgestrel Low comb mg P 10 EP 0.045 mg E + 0.040 3 Patch estradiol + levonorgestrel Low 4 comb mg P von Holst 1 88 Plac Patch 2002 0.05 mg E + 0.01 mg Standar 2 84 EP seq Patch estradiol + levonorogestrel Fem7 Combi P d Archer 2003 1 73 Plac SknGel

2 75 Est 0.75 mg SknGel estradiol EstroGel Low 3 73 Est 1.5 mg SknGel estradiol EstroGel Low

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Vestergaard 50 1 Plac Oral 2003 4 50 Standar 2 EP seq 2 mg E + 1 mg P Oral estradiol + norethisterone acetate Trisequens 2 d Speroff 2003 10 1 Plac VayRin 8 11 EP 2 0.05 mg VayRin estradiol + progestin Femring High 3 comb 11 EP 3 0.10 mg VayRin estradiol + progestin Femring High 2 comb Jirapinyo 1 60 Plac Oral 2003 EP Standar 2 60 2 mg E + 1 mg P Oral estradiol + norethisterone acetate Kliogest comb d Haines 2003 1 50 Plac Oral

2 52 Est 1 mg Oral estradiol Low

Standar 3 50 Est 2 mg Oral estradiol d Hays 2003 81 1 Plac Oral 02 85 EP 0.625mg E + 2.5mg conjugated equine estrogen + Standar 2 Oral Prempro 06 comb P medroxyprogesterone acetate d Gambacciani 1 25 Plac Oral 2003 EP 2 25 1 mg E + 0.5 mg P Oral estradiol + norethisterone Activelle Low comb Gelfand 2003 1 60 Plac Oral

EP 2 59 1 mg E + 0.09 mg P Oral estradiol + norgestimate Ortho-Prefest Low comb Wren 2003 1 42 Plac SknCr

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Ar Est Study N RxCat Dose Route Generic Trade m Dose m SknCr 2 38 Prog 32 mg progesterone Pro-Feme m Simunic 2003 78 1 Plac VagTab 4 82 2 Est 0.025mg VagTab estradiol Vagifem Low 8 Parsons 2003 VagCr Replens (nonhormonal 1 46 Plac m moisturizer) VagCr Standar 2 48 Est 0.625 mg conjugated estrogen Premarin m d Berlex (SIP) 1 88 Plac Patch 2003 EP .045 mg E + .03 mg Standar 2 92 Patch Estradiol + Levonorgestrel Climara Pro comb P d Rudolph 2004 1 64 Plac Oral

EP Climodien/Lafam 2 65 2mg E + 2mg P Oral estradiol valerate + dienogest High comb me Yang 2004 1 25 Plac Oral

EP 0.625mg E + 2.5mg conjugated estrogen + Standar 2 26 Oral Premelle comb P medroxyprogesterone acetate d Schurmann 1 61 Plac Oral 2004 EP 2 55 1mg E + 1mg P Oral estradiol + drospirenone Low comb EP 3 52 1mg E + 2mg P Oral estradiol + drospirenone Low comb EP 4 57 1mg E + 3mg P Oral estradiol + drospirenone Low comb Utian 2004 1 72 Plac Oral

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Ar Est Study N RxCat Dose Route Generic Trade m Dose UltraLo 2 68 Est 0.3mg Oral synthetic conjugated estrogen Enjuvia w Standar 3 72 Est 0.625mg Oral synthetic conjugated estrogen Enjuvia d 4 69 Est 1.25mg Oral synthetic conjugated estrogen Enjuvia High Dessole 2004 VagOv 1 44 Plac u VagOv 2 44 Est 1mg estriol Colpogyn Low u Duramed 1 51 Plac Oral (SIP) 2004 2 53 Est .45mg Oral synthetic conjugated estrogens Cenestin Low Brunner 2005 54 1 Plac Oral 29 53 Standar 2 Est 0.625 mg Oral conjugated equine estrogens Premarin 10 d Onalan 2005 Calcium Sandoz 1 54 Plac 1000 mg Oral calcium Forte conjugated equine estrogen EP 0.625 mg E + 2.5 mg Standar 2 79 Oral (CEE) + medroxyprogesterone Premelle 2.5 comb P d acetate (MPA) conjugated equine estrogen EP 0.625 mg E + 5.0 mg Standar 3 77 Oral (CEE) + medroxyprogesterone Premelle 5 comb P d acetate (MPA) Bayer 17 Healthcare 1 Plac Oral 6 (SIP) 2005 17 EP 0.50 mg E + 0.25 mg 2 Oral estradiol + drospirenone Angeliq Low 5 comb P Novartis (SIP) 1 51 Plac Patch

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Ar Est Study N RxCat Dose Route Generic Trade m Dose 2005 EP 0.05 mg E + 0.14 mg 2 57 Patch estradiol + norethindrone acetate CombiPatch Low comb P EP 0.05 mg E + 0.25 mg 3 52 Patch estradiol + norethindrone acetate CombiPatch Low comb P Speroff (Study 1) 1 94 Plac Oral

2006 10 Standar 2 Est 0.9 mg Oral estradiol acetate Femtrace 0 d 3 95 Est 1.8 mg Oral estradiol acetate Femtrace High Simon 2006 10 SknCr 1 Plac 0 m 10 SknCr 2 Est 2.5 mg/1g of cream estradiol Estrasorb Low 0 m Nielsen 2006 11 1 Plac NasSpr 8 11 0.15 mg E + 200mg estradiol (S21400) + Aerodiol + 2 EP seq NasSpr Low 4 P progesterone progesterone 10 0.30 mg E + 200 mg estradiol (S21400) + Aerodiol + Standar 3 EP seq NasSpr 3 P progesterone progesterone d Osmanagaogl 1 51 Plac Oral u 2006 EP estradiol valerate (EV) + 2 53 2 mg E + 2 mg P Oral Climodien High comb dienogest (P) Speroff 10 (Study 2) 1 Plac Oral 8 2006 11 2 Est 0.45 mg Oral estradiol acetate Femtrace Low 3

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Bachmann (d) 13 1 Plac Patch 2007 3 14 UltraLo 2 Est 0.014 mg Patch estradiol 7 w 14 EP 0.023 mg E + 0.0075 UltraLo 3 Patch estradiol + levonorgestrel 5 comb mg P w Maki 2007 1 91 Plac Oral

EP 0.625mg E + 2.5mg conjugated equine estrogen + Standar 2 89 Oral Prempro comb P medroxyprogesterone acetate d Endrikat 2007 16 1 Plac Oral 2 16 EP Standar 2 1mg E + 2mg P Oral estradiol valerate + dienogest 2 comb d Lee 2007 1 37 Plac Oral

EP 2 35 1 mg E + 2 mg P Oral estradiol + drospirenone Low comb Panay 2007 20 1 Plac Oral 0 19 EP UltraLo 2 0.5 mg E + 0.1 mg P Oral estradiol + norethisterone acetate 4 comb w 18 EP 0.5 mg E + 0.25 mg UltraLo 3 Oral estradiol + norethisterone acetate 1 comb P w Simon 2007 13 1 Plac SknGel 7 13 2 Est 0.52 mg SknGel estradiol Elestrin Low 6 14 3 Est 1.02 mg SknGel estradiol Elestrin Low 2 4 69 Est 1.56 mg SknGel estradiol Elestrin Low Pefanco 2007 1 25 Plac Oral

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Ar Est Study N RxCat Dose Route Generic Trade m Dose UltraLo 2 32 EP seq 0.25mg + 100mg P Oral estradiol + progesterone w Bayer Healthcare 1 83 Plac Patch

(SIP) 2007 UltraLo 2 82 Est .025 mg Patch estradiol Climara w Buster (Study 1 75 Plac SknSpr 1) 2008 2 76 Est 4.59 mg SknSpr estradiol Evamist Low Veerus 2008 38 1 Plac Oral 1 41 EP Standar 2 0.625 mg + 2.5 mg Oral combined estrogens + medroxyprogestrone acetate 5 comb d Davis 2008 27 1 Plac Patch 7 26 2 Test 0.15 mg Patch 7 26 3 Test 0.30 mg Patch 7 Bachmann 1 47 Plac VagTab 2008 2 92 Est 0.01 mg VagTab estradiol Vagifem Low 3 91 Est 0.025 mg VagTab estradiol Vagifem Low Welton 2008 10 1 Plac Oral 87 10 EP conjugated equine estrogen + Standar 2 0.625 E + 2.5/5.0 P Oral Prempro 43 comb medroxyprogesterone acetate d Buster (Study 1 76 Plac SknSpr 2) 2008

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Ar Est Study N RxCat Dose Route Generic Trade m Dose 2 74 Est 3.06 mg SknSpr estradiol Evamist Low Buster (Study 1 77 Plac SknSpr 3) 2008 2 76 Est 1.53 mg SknSpr estradiol Evamist Low Simon (SIP) 12 1 Plac Oral 2008 3 12 2 Est 0.3 mg Oral synthetic conjugated estrogens Enjuvia Low 5 Benster 2009 SknCr 1 43 Plac m SknCr 2 46 Prog 5 mg progestin Progestelle m SknCr 3 44 Prog 20 mg progestin Progestelle m SknCr 4 43 Prog 40 mg progestin Progestelle m SknCr 5 45 Prog 60 mg progestin Progestelle m Utian 2009 1 63 Plac Oral

12 2 Est 0.45 E + 20 BZA Oral conjugated equine estrogens + bazedoxifene Low 7 12 Standar 3 Est 0.625 E + 20 BZA Oral conjugated equine estrogen + bazedoxifene 8 d Lobo 2009 42 1 Plac Oral 7 12 2 Est 0.45 E + (10-40 BZA Oral conjugated equine estrogen + bazedoxifene Low 86 12 0.625 E + (10-40) Standar 3 Est Oral conjugated equine estrogen + bazedoxifene 61 BZA d Haines 2009 1 80 Plac Patch

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Ar Est Study N RxCat Dose Route Generic Trade m Dose UltraLo 2 80 Est 0.014 mg Patch estradiol w Bachmann (d) 1 36 Plac Patch 2009 UltraLo 2 42 Est 0.014 mg Patch estradiol w EP 0.023mg E + UltraLo 3 43 Patch estradiol + levonorgestrel comb 0.0075mg P w Hedrick 2009 12 1 Plac SknGel 5 12 2 Est 0.25 mg SknGel estradiol Divigel Low 2 12 3 Est 0.5 mg SknGel estradiol Divigel Low 3 12 4 Est 1.0 mg SknGel estradiol Divigel Low 5 Baksu 2009 1 32 Plac Oral

Standar 2 35 Est 0.625 mg Oral conjugated estrogen Premarin d Standar 3 33 Est 0.3 mg NasSpr estradiol hemihidrate Aerodiol d Standar 4 32 Est 1.5 mg SknGel estradiol hemihidrate Estreva d Bachmann VagCr (Study 1) 1 72 Plac m 2009 14 VagCr UltraLo 2 Est 0.3 mg conjugated estrogen 3 m w Freedman 14 VagCr 1 Plac 2009 0 m

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Ar Est Study N RxCat Dose Route Generic Trade m Dose 13 VagCr Standar 2 Est 0.179mg synthetic conjugated estrogens-A 5 m d Gast 2009 14 1 Plac Oral 1 0.45 mg E + 1.5 mg 14 EP conjugated estrogen + 2 MPA oral + 0.625 mg Oral Premarin Low 4 comb medroxyprogesterone acetate cream Bachmann VagCr (Study 2) 1 68 Plac m 2009 14 VagCr 2 Est 0.3 mg conjugated estrogen Low 0 m Hassa 2010 1 83 Plac Injec

Standar 2 83 Est 0.625 mg Oral conjugated equine estrogen Premarin d Standar 3 81 Est 0.56 mg Patch estradiol Climara d Stevenson 12 1 Plac Oral 2010 7 12 EP UltraLo 2 0.5 mg E + 2.5 mg D Oral estradiol and dydrogesterone 4 comb w EP 3 62 1 mg E + 5 mg D Oral estradiol and dydrogesterone Low comb Bachmann 10 1 Plac Oral 2010 5 21 2 Est 0.45 E + 20 BZA Oral conjugated equine estrogen + bazedoxifene Low 9 21 Standar 3 Est 0.625 E + 20 BZA Oral conjugated equine estrogen + bazedoxifene 8 d Raghunandan 1 25 Plac VagCr

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Ar Est Study N RxCat Dose Route Generic Trade m Dose 2010 m VagCr Standar 2 25 Est 0.625 mg conjugated equine estrogen Premarin m d ET VagCr conjugated equine estrogen + Premarin + Standar 3 25 0.625 mg E + 2% T comb m testosterone testosterone d Hedrick 2010 12 1 Plac SknGel 4 12 2 Est 0.25 mg SknGel estradiol Divigel Low 1 11 3 Est 0.50 mg SknGel estradiol Divigel Low 9 12 4 Est 1 mg SknGel estradiol Divigel Low 4 Liu 2011 16 1 Plac Oral 8 17 2 Est 0.30 mg Oral esterified estrogen Low 2 17 ET 0.30 mg E + 0.30 mg 3 Oral esterified estrogen + methyltestosterone Low 2 comb MT 17 ET 0.30 mg E + 0.60 mg 4 Oral esterified estrogen + methyltestosterone Low 4 comb MT 16 5 Est 0.45 mg EE Oral esterified estrogen Low 8 17 6 Test 0.60 mg Oral methyltestosterone 5 Lin 2011 1 61 Plac Oral

18 EP 2 1 mg E + 2 mg P Oral estradiol + drospirenone Low 3 comb Demetrio 1 36 Plac Oral 2011

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Ar Est Study N RxCat Dose Route Generic Trade m Dose Standar 2 30 Est 0.625 mg Oral conjugated equine estrogen Premarin d Liu 2012 1 52 Plac Oral

UltraLo 2 53 Est 0.3mg Oral synthetic conjugated estrogen-B Enjuvia w Standar 3 52 Est 0.625mg Oral synthetic conjugated estrogen-B Enjuvia d Archer 2012 11 1 Plac SknGel 4 11 2 Est 0.27 mg SknGel Estradiol EstroGel Low 8 11 3 Est 0.375 mg SknGel Estradiol EstroGel Low 9 Archer 2012 11 1 Plac SknGel 3 11 2 Est 0.27 SknGel estradiol EstroGel 0.06% Low 6 11 3 Est 0.375 SknGel estradiol EstroGel 0.06% Low 5 Cano 2012 1 53 Plac VagGel

11 UltraLo 2 Est 0.05 VagGel estriol 4 w Polisseni 1 44 Plac Oral 2013 EP 2 44 1 E + 0.5 P Oral estradiol + NETA Low comb Raz 2013 1 26 Plac Oral

2 33 EP comb Oral CEE or estradiol with progesterone Low Archer 2013 17 1 Plac Oral 6

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Ar Est Study N RxCat Dose Route Generic Trade m Dose 17 EP UltraLo 2 0.5 E + 0.25 P Oral estradiol + drospirenone 7 comb w 17 EP UltraLo 3 0.5 E + 0.5 P Oral estradiol + drospirenone 8 comb w 17 UltraLo 4 Est 0.3 Oral estradiol 9 w Pinkerton 11 1 Plac Oral 2013 6 11 2 Est 0.45 E + 20 BZA Oral conjugated equine estrogen + bazedoxifene Low 5 12 Standar 3 Est 0.625 E + 20 BZA Oral conjugated equine estrogen + bazedoxifene 3 d EP conjugated equine estrogen + medrozyprogesterone 4 56 0.45 E + 1.5 P Oral Low comb acetate (a): data came from a conference abstract; (c): data came from posted results on the clinical trial registry; (d): duplicate patient population with other included article; E: estrogen; EP comb: estrogen plus progestin; Est: estrogen alone; ET comb: estrogen plus testosterone; (m): trial contains data from multiple publications; NasSpr: nasal spray; P: progestin; Prog: progestin alone; Plac: placebo; RxCat: treatment category; SD: standard deviation; (SIP); data came from a package insert; SknGel: skin gel; Test: testosterone alone; VagCrm: vaginal cream; VagOvu: vaginal ovule; VagPes: vaginal pessary; VagRin: vaginal ring; VagTab: vaginal tablet

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