Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics Status: Draft Tentative Report for Panel Review Release Date: May 22, 2015 Panel Meeting Date: June 15-16, 2015 The 2015 Cosmetic Ingredient Review Expert Panel members are: Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D., Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Director is Lillian J. Gill, D.P.A. This report was prepared by Christina Burnett, Senior Scientific Analyst/Writer. Cosmetic Ingredient Review 1620 L Street NW, Suite 1200 ♢ Washington, DC 20036-4702 ♢ ph 202.331.0651 ♢ fax 202.331.0088 ♢
[email protected] Commitment & Credibility since 1976 Memorandum To: CIR Expert Panel Members and Liaisons From: Christina Burnett, Senior Scientific Writer/Analyst Date: May 22, 2015 Subject: Draft Tentative Safety Assessment on Citrus Fruit-Derived Ingredients Enclosed is the draft Tentative Report of the Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics. (It is identified as cfruit062015rep in the pdf document.) At the March 2015 CIR Panel Meeting, the Expert Panel requested additional data to support the safety of citrus fruit- derived ingredients. The additional data needs were: (1) methods of manufacture; (2) chemical composition and impurities data; (3) irritation and sensitization data, specifically HRIPT on citrus aurantium dulcis (orange) fruit water, citrus limon (lemon) fruit extract, and citrus grandis (grapefruit) fruit extract at maximum use concentrations; (4) confirmation from RIFM that citrus aurantium bergamia (bergamot) fruit oil, citrus junos fruit oil, citrus junos fruit water, citrus natsudaidai flower water, citrus reticulata (tangerine) fruit water, and citrus unshiu/citrus reticulata/citrus iyo fruit water has, or will be, assessed by RIFM; and (5) confirmation on which species of citrus fruit are not GRAS food ingredients from the FDA.