MEN1-Related Pancreatic Nets: Identification of Unmet Clinical

Total Page:16

File Type:pdf, Size:1020Kb

MEN1-Related Pancreatic Nets: Identification of Unmet Clinical 27 8 Endocrine-Related C R C Pieterman, Future directives in 27:8 T9–T25 Cancer S M Sadowski et al. MEN1-related PanNETs THEMATIC REVIEW HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES MEN1-related pancreatic NETs: identifcation of unmet clinical needs and future directives C R C Pieterman1,2,*, S M Sadowski3,*, J E Maxwell4, M H G Katz4, K E Lines5, C M Heaphy6,†, A Tirosh7, J E Blau8, N D Perrier1, M A Lewis9,10, J P Metzcar11,12, D M Halperin13, R V Thakker5 and G D Valk2 1Section of Surgical Endocrinology, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands 3Endocrine Surgery, Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA 5Academic Endocrine Unit, Radclife Department of Medicine, OCDEM, University of Oxford, Oxford, UK 6Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 7Neuroendocrine Tumors Service, Division of Endocrinology, Metabolism and Diabetes, The Chaim Sheba Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel 8Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA 9Gastrointestinal Oncology, Intermountain Healthcare, Murray, Utah, USA 10American Multiple Endocrine Neoplasia Support (AMENSupport), Maryville, Tennessee, USA 11Association of Multiple Endocrine Neoplasia Disorders (AMEND), Bloomington, Indiana, USA 12Departments of Intelligent Systems Engineering and Informatics, Indiana University, Bloomington, Indiana, USA 13Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Correspondence should be addressed to D M Halperin: [email protected] *(C R C Pieterman and S M Sadowski contributed equally to this work) †(C M Heaphy is now at Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA) This paper is part of a thematic section on current knowledge and future research opportunities in hereditary endocrine tumours, as discussed at MEN2019: 16th International Workshop on Multiple Endocrine Neoplasia, 27–29 March 2019, Houston, TX, USA. This meeting was sponsored by Endocrine-Related Cancer Abstract The PanNET Working Group of the 16th International Multiple Endocrine Neoplasia Key Words Workshop (MEN2019) convened in Houston, TX, USA, 27–29 March 2019 to discuss key f MEN1 unmet clinical needs related to PanNET in the context of MEN1, with a special focus on f multiple endocrine non-functioning (nf)-PanNETs. The participants represented a broad range of medical neoplasia type 1 scientists as well as representatives from patient organizations, pharmaceutical industry f pancreatic neuroendocrine tumor and research societies. In a case-based approach, participants addressed early detection, f conference proceeding surveillance, prognostic factors and management of localized and advanced disease. f unmet clinical needs For each topic, after a review of current evidence, key unmet clinical needs and future f research infrastructure research directives to make meaningful progress for MEN1 patients with nf-PanNETs f management were identifed. International multi-institutional collaboration is needed for adequately f risk stratifcation sized studies and validation of fndings in independent datasets. Collaboration between f surveillance basic, translational and clinical scientists is paramount to establishing a translational f management science approach. In addition, bringing clinicians, scientists and patients together f treatment improves the prioritization of research goals, assures a patient-centered approach https://erc.bioscientifca.com © 2020 Society for Endocrinology https://doi.org/10.1530/ERC-19-0441 Published by Bioscientifca Ltd. Printed in Great Britain Downloaded from Bioscientifica.com at 07/30/2020 09:08:56PM via free access -19-0441 Endocrine-Related C R C Pieterman, Future directives in 27:8 T10 Cancer S M Sadowski et al. MEN1-related PanNETs and maximizes patient involvement. It was concluded that collaboration, research infrastructure, methodologic and reporting rigor are essential to any translational science efort. The highest priority for nf-PanNETs in MEN1 syndrome are (1) the development of a data and biospecimen collection architecture that is uniform across all MEN1 centers, (2) unifed strategies for diagnosis and follow-up of incident and prevalent nf-PanNETs, (3) non-invasive detection of individual nf-PanNETs that have an increased risk of metastasis, (4) chemoprevention clinical trials driven by basic research studies and (5) therapeutic targets for advanced disease based on biologically plausible mechanisms. Endocrine-Related Cancer (2020) 27, T9–T25 Introduction For each topic, after a review of the current clinical understanding, the key unmet clinical needs and future Multiple endocrine neoplasia type 1 (MEN1), caused by research directives to make meaningful progress for pathogenic variants in the MEN1 gene on chromosome MEN1 patients with nf-PanNETs were identifed. 11q13, is a rare neuroendocrine tumor (NET) susceptibility syndrome with an approximate prevalence of 1 in 30,000 (Chandrasekharappa et al. 1997). By the age of Clinical case 80 more than 80% of the patients will have developed a duodenopancreatic NET (de Laat et al. 2016) and The patient is a 42-year-old female. She has recently multifocality is common. Non-functional pancreatic been diagnosed with MEN1 by genetic screening NETs (nf-PanNETs) are the most common type of through her 46-year-old brother, the index case. She PanNET in patients with MEN1, followed by gastrinoma, has an unremarkable medical history. She denies insulinoma and other rarer functional tumors. Metastatic any symptoms of hypoglycemia (insulinoma), duodenopancreatic NETs are the most frequent cause of acid refux, diarrhea or peptic ulcer disease disease-related death in patients with MEN1 (hazard ratio (gastrinoma) or newly developed diabetes and skin (HR) for death = 3.43 for nf-PanNETs; 95% CI 1.71–6.88) rash (glucagonoma), other functional PanNETs or (Goudet et al. 2010). Early detection or prevention are ideal, mechanical symptoms. Her vital signs and general as surgery is the only curative treatment, feasible only for physical examination are unremarkable. localized NETs. Continued systematic duodenopancreatic NET screening and follow-up are warranted, especially since MEN1 patients frequently develop additional Diagnosis and follow-up of nf-PanNETs in primaries in remnant duodenopancreatic tissue (Dralle patients with MEN1 et al. 2004, Thakker et al. 2012). Question 1: Do we need new blood-based biomarkers The PanNET Working Group of the 16th International for the diagnosis of nf-PanNETs in MEN1 and how Multiple Endocrine Neoplasia Workshop (MEN2019) should we study this? convened in Houston, TX, USA, 27–29 March 2019 to discuss key unmet clinical needs related to PanNET in State of evidence the context of MEN1, with a special focus on nf-PanNETs. Current clinical practice guidelines, published in 2012, The participants represented a broad range of medical balanced expert opinion with scarce scientifc evidence scientists including basic, translational and clinical to provide the framework of care for MEN1 patients. scientists from the felds of Endocrinology, Medical The guidelines recommended that annual screening Oncology, Surgical Oncology, Surgical Endocrinology for nf-PanNET should include fasting glucagon, and Genetic Counseling. Representatives from the chromogranin A (CgA) and pancreatic polypeptide (PP) North American and UK MEN patient advocacy groups which would expand evidence regarding their diagnostic (AMENsupport, AMEND USA and UK) were present, as value (Thakker et al. 2012). A recent systematic review were representatives from the pharmaceutical industry on the diagnosis of nf-PanNETs in MEN1, with strict and the Neuroendocrine Tumor Research Foundation defnitions of research quality and risk of bias, has (NETRF). In a case-based approach, participants addressed summarized evidence from multiple studies (van Treijen early detection, surveillance, prognostic factors and et al. 2018b). Most studies had signifcant risk of bias. Two management of localized and advanced disease. studies with the highest quality of evidence and a low https://erc.bioscientifca.com © 2020 Society for Endocrinology https://doi.org/10.1530/ERC-19-0441 Published by Bioscientifca Ltd. Printed in Great Britain Downloaded from Bioscientifica.com at 07/30/2020 09:08:56PM via free access Endocrine-Related C R C Pieterman, Future directives in 27:8 T11 Cancer S M Sadowski et al. MEN1-related PanNETs risk of bias showed low accuracy of the tumor markers function impairment. Furthermore, routine blood work (de Laat et al. 2013, Qiu et al. 2016), and annual use may already be a part of the patient’s life, more accessible in of CgA, PP and glucagon for the diagnosis of nf-PanNETs terms of travel, and less costly, all of which might facilitate in MEN1 was not recommended (van Treijen et al. 2018b). more consistent monitoring as warranted by disease stage Therefore, there are currently no available biomarkers to and quality of life (QoL).
Recommended publications
  • Downloaded from Bioscientifica.Com at 09/30/2021 02:21:58AM Via Free Access
    27 8 Endocrine-Related C R C Pieterman, Future directives in 27:8 T9–T25 Cancer S M Sadowski et al. MEN1-related PanNETs THEMATIC REVIEW HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES MEN1-related pancreatic NETs: identification of unmet clinical needs and future directives C R C Pieterman1,2,*, S M Sadowski3,*, J E Maxwell4, M H G Katz4, K E Lines5, C M Heaphy6,†, A Tirosh7, J E Blau8, N D Perrier1, M A Lewis9,10, J P Metzcar11,12, D M Halperin13, R V Thakker5 and G D Valk2 1Section of Surgical Endocrinology, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands 3Endocrine Surgery, Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA 5Academic Endocrine Unit, Radcliffe Department of Medicine, OCDEM, University of Oxford, Oxford, UK 6Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 7Neuroendocrine Tumors Service, Division of Endocrinology, Metabolism and Diabetes, The Chaim Sheba Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel 8Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA 9Gastrointestinal Oncology, Intermountain
    [Show full text]
  • ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors
    ENETS Consensus Guidelines Neuroendocrinology 2016;103:153–171 Published online: January 5, 2016 DOI: 10.1159/000443171 ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors a b c d e f M. Falconi B. Eriksson G. Kaltsas D.K. Bartsch J. Capdevila M. Caplin g h i j k l B. Kos-Kudla D. Kwekkeboom G. Rindi G. Klöppel N. Reed R. Kianmanesh m R.T. Jensen all other Vienna Consensus Conference participants a b Department of Surgery, San Raffaele Hospital, Università Vita e Salute, Milan , Italy; Department of Endocrine Oncology, c University Hospital, Uppsala , Sweden; Department of Pathophysiology, Division of Endocrinology, National University d e of Athens, Athens , Greece; Department of Surgery, Philipps University, Marburg , Germany; Institute of Oncology f (VHIO), Vall d’Hebron University Hospital, Barcelona , Spain; Neuroendocrine Tumour Unit, Royal Free Hospital, London , g h UK; Department of Endocrinology, Medical University of Silesia, Katowice , Poland; Department of Internal Medicine, i Division of Nuclear Medicine, Erasmus Medical Center, Rotterdam , The Netherlands; Institute of Anatomic Pathology, j Policlinico A. Gemelli, Università Cattolica del Sacro Cuore, Rome , Italy; Institute of Pathology, Technische Universität k l München, Munich , Germany; Beatson Oncology Centre, Gartnavel General Hospital, Glasgow , UK; Department of m Surgery, CHU Robert Debré, Reims , France; Digestive Diseases Branch, NIH, Bethesda, Md. , USA Introduction be considered in three groups: the more frequent gastri- nomas and insulinomas considered independently and Only advances that occurred from 2011 to 2014 that all the rare F-P-NETs (RFTs) considered together and as either strengthen the previous 2011 guidelines [1, 2] or a separate category (Appendix 1 and table 1).
    [Show full text]
  • Epigenetic Alterations in Endocrine- Related Cancer
    S Rodrı´guez-Rodero et al. Epigenetics and endocrine 21:4 R319–R330 Review cancer Epigenetic alterations in endocrine- related cancer Sandra Rodrı´guez-Rodero1,2, Elı´as Delgado-A´ lvarez1, Agustı´n F Ferna´ndez2, Juan L Ferna´ndez-Morera1, Edelmiro Mene´ndez-Torre1 and Mario F Fraga2,3 Correspondence 1Endocrinology and Nutrition Service, Hospital Universitario Central de Asturias, Av. Julian Claverı´a s/n, should be addressed 33006 Oviedo, Spain to E Mene´ ndez-Torre or 2Cancer Epigenetics Laboratory, Instituto Universitario de Oncologı´a del Principado de Asturias (IUOPA), M F Fraga Universidad de Oviedo, 33006 Oviedo, Spain Emails 3Department of Immunology and Oncology, National Center for Biotechnology, CNB-CSIC, Cantoblanco, [email protected] or Madrid E-28049, Spain [email protected] Abstract Aberrant epigenetics is a hallmark of cancer, and endocrine-related tumors are no exception. Key Words Recent research has been identifying an ever-growing number of epigenetic alterations in " multiple endocrine both genomic DNA methylation and histone post-translational modification in tumors of the neoplasias endocrine system. Novel microarray and ultra-deep sequencing technologies have allowed " neuroendocrine tumors the identification of genome-wide epigenetic patterns in some tumor types such as " oncology adrenocortical, parathyroid, and breast carcinomas. However, in other cancer types, such " pathogenesis as the multiple endocrine neoplasia syndromes and thyroid cancer, tumor information is limited to candidate genes alone. Future research should fill this gap and deepen our understanding of the functional role of these alterations in cancer, as well as defining Endocrine-Related Cancer their possible clinical uses. Endocrine-Related Cancer (2014) 21, R319–R330 Introduction Epigeneticsisdefinedasthestudyofthosestable However, all such mechanisms in fact cooperate with each genetic modifications that result in changes in function other, and also with other levels of regulation, to establish and gene expression without altering the DNA sequence.
    [Show full text]
  • Endocrine Oncology: Special Issue
    Metab y & o OPEN ACCESS Freely available online g lic lo S o y n n i r d c r o o Endocrinology & Metabolic Syndrome m d n e E ISSN: 2161-1017 Editorial Endocrine Oncology: Special Issue Ilene Fennoy* Department of Pediatrics, Division of Pediatric Diabetes, Endocrinology and Metabolism, Columbia University, New York, New York, USA About Special Issue • Small cell lung cancer Endocrinology & Metabolic Syndrome is an Open Access journal Endocrine pancreatic Tumors with rapid peer-reviewed publishes in the field like biosynthesis, Types of Endocrine pancreatic Tumorsare listed below storage, chemistry, and physiological function of hormones and the cells of endocrine glands and tissues that secrete them. • Non-functioning endocrine pancreatic tumors Endocrinology is happy to announce its Special Issue on “Endocrine • Insulinoma Oncology”. Endocrinology is offering special discounts on APC • Gastrinoma (Article Processing Charges) and immediate publication (within 21days from initial date of submission). Our Journal is planning to • Glucagonoma release issue by end of the Year i.e., Dec 30th, 2020. • VIPoma Endocrine oncologyis a medical specialty deals with the production Adrenals Tumors of hormones and tumors. There are several kinds of endocrine tumors, and are listed below Types of Adrenals Tumorsare listed below • Thyroid Cancer • Adrenocortical carcinoma • Parathyroid Tumors • Pheochromocytoma • Adrenocortical Carcinoma Syndromes of Endocrine Tumor • Pheochromocytoma Types of Syndromes of Endocrine Tumor are listed below • Neuroendocrine Tumors • Multiple Endocrine Neoplasia I, MEN1 • Pituitary Tumors • Multiple Endocrine Neoplasia II, MEN2 Gastrointestinal Tumors • von HippelLindau syndrome Types of gastrointestinal tumours are listed as below We are proud and glad to announce that our journal is ready to release volume 9Issue 7 in this year 2020 and the last issue of this • ECLoma year.
    [Show full text]
  • American Association of Endocrine Surgeons
    THE AMERICAN ASSOCIATION OF ENDOCRINE SURGEONS Thirty-Sixth Annual Meeting MAY 17-19, 2015 The Omni Nashville Hotel Nashville, TN THANK YOU The American Association of Endocrine Surgeons would like to thank the following companies for their generous support of our meeting through educational grants and sponsorships*: Platinum Level Support Neurovision Section of Surgical Sciences, Vanderbilt University Medical Center Gold Level Support Genzyme Silver Level Support Boston Medical Center Ethicon Bronze Level Support AstraZeneca Vanderbilt Endocrine and Eskind Diabetes Clinic Additional support from: Mary Ann Liebert Publishers and Veracyte The American Association of Endocrine Surgeons Foundation would like to thank the following company for their generous support of the Paul LoGerfo Educational Research Award through an annual grant: Elsevier, Inc. The American Association of Endocrine Surgeons gratefully acknowledges the support of the following exhibiting companies*: Akrimax Eisai, Inc. Medtronic Pharmaceuticals EndocrineWeb.com Memorial Healthcare Ambry Genetics Ethicon US, LLC System American Association of Future Diagnostics Neurovision Medical Clinical Endocrinologists GE Healthcare Products, Inc. (AACE) Genzyme, a Sanofi Olympus American Multiple Company Onyx Pharmaceuticals Neoplasia Support Sense Medical (AMEN) Graves’ Disease & Thyroid Foundation Shire American Thyroid Association (ATA) HealthBreeze ThyCa: Thyroid Cancer Survivors’ Association ArborMetrix, Inc. Hitachi Aloka Medical Thyroid Cancer Care CBLPath Interpace Diagnostics
    [Show full text]
  • Diagnosis and Management of Neuroendocrine Tumors Page 1 of 10
    Diagnosis and Management of Neuroendocrine Tumors Page 1 of 10 [ ACP Medicine ] [ MedGenMed eJournal Latest News CME Conferences Resource Centers Patient Ed. Journals & Reference Experts & Viewpoints Search Medscape, MEDLINE and Drug Reference Search Newsletters | Log Out | Return to Medscape coverage of: 8th United European Gastroenterology Week Diagnosis and Management of Neuroendocrine Tumors Disclosures Rudolph Arnold, MD, FRCP Background Definitions and Terminology Endocrine tumors of the digestive system are rare events and present with widely variable and often dramatic clinical syndromes. Several synonyms are currently used by clinicians and pathologists for these tumors, including "carcinoid tumor," "APUD-oma," "gastro-entero-pancreatic (GEP) tumor," "islet cell tumor," "neuroendocrine tumor," and "neuroendocrine carcinoma." The term "carcinoid" was introduced in 1902 by Oberndorfer [1] for malignant tumors arising in the small intestine that formed metastases but differed from other malignancies by a slow tumor growth. [1] The terminology was confined to endocrine tumors of the esophagus, stomach, small and large intestine, and of organs developing from the digestive tract (such as the bronchial system). Pancreatic endocrine tumors, despite revealing histologically many similarities with carcinoids, were excluded from this classification because of the different organogenesis of the pancreas. Recent consensus meetings suggested that the more appropriate term "neuroendocrine tumor" be used for all endocrine tumors of the digestive system, because all such tumors derive from the diffuse neuroendocrine system. [2,3] To this system belong: (a) the pancreas; (b) the mucosa of the gastrointestinal tract containing at least 15 different endocrine cell types producing hormonal peptides and/or biogenic amines [4,5] ; and (c) endocrine cells scattered in other endodermal sites (such as the thyroid, lung, biliary tree, and the urogenital tract).
    [Show full text]
  • Gastroduodenal Neuroendocrine Neoplasms, Including Gastrinoma — Management Guidelines (Recommended by the Polish Network of Neuroendocrine Tumours)
    SZKOLENIE PODYPLOMOWE/POSTGRADUATE EDUCATION Endokrynologia Polska DOI: 10.5603/EP.2017.0016 Tom/Volume 68; Numer/Number 2/2017 ISSN 0423–104X Gastroduodenal neuroendocrine neoplasms, including gastrinoma — management guidelines (recommended by the Polish Network of Neuroendocrine Tumours) Michał Lipiński1*, Grażyna Rydzewska1*, Wanda Foltyn2, Elżbieta Andrysiak-Mamos3**, Agata Bałdys-Waligórska4**, Tomasz Bednarczuk5**, Jolanta Blicharz-Dorniak6**, Marek Bolanowski7**, Agnieszka Boratyn-Nowicka8**, Małgorzata Borowska6**, Andrzej Cichocki9**, Jarosław B. Ćwikła10**, Massimo Falconi11*, Daria Handkiewicz-Junak12**, Alicja Hubalewska-Dydejczyk4**, Barbara Jarząb12**, Roman Junik13**, Dariusz Kajdaniuk14**, Grzegorz Kamiński15**, Agnieszka Kolasińska-Ćwikła16**, Aldona Kowalska17**, Robert Król18**, Leszek Królicki19**, Jolanta Kunikowska19**, Katarzyna Kuśnierz20**, Paweł Lampe20**, Dariusz Lange21**, Anna Lewczuk-Myślicka22**, Andrzej Lewiński23**, Magdalena Londzin-Olesik6**, Bogdan Marek14**, Anna Nasierowska-Guttmejer24**, Ewa Nowakowska-Duława25**, Joanna Pilch-Kowalczyk26**, Karolina Poczkaj6**, Violetta Rosiek2**, Marek Ruchała27**, Lucyna Siemińska14**, Anna Sowa-Staszczak4**, Teresa Starzyńska28**, Katarzyna Steinhof-Radwańska26**, Janusz Strzelczyk2**, Krzysztof Sworczak22**, Anhelli Syrenicz3**, Andrzej Szawłowski29**, Marek Szczepkowski30**, Ewa Wachuła8**, Wojciech Zajęcki6**, Anna Zemczak6**, Wojciech Zgliczyński31**, Beata Kos-Kudła2*** 1Department of Gastroenterology, Central Clinical Hospital of the Ministry of Interior
    [Show full text]
  • Multiple Endocrine Neoplasia Type 1 in Poland: a Two-Centre Experience
    Original paper Endokrynologia Polska DOI: 10.5603/EP.a2019.0031 Volume/Tom 70; Number/Numer 5/2019 ISSN 0423–104X Multiple endocrine neoplasia type 1 in Poland: a two-centre experience Przemysław Soczomski1, Beata Jurecka-Lubieniecka1, Natalia Rogozik2, Andrzej Tukiendorf3, Barbara Jarząb1, Tomasz Bednarczuk2 1Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute — Oncology Centre Gliwice Branch, Gliwice, Poland 2Department of Internal Diseases and Endocrinology, Medical University of Warsaw, Warsaw, Poland 3Department of Public Health, Wroclaw Medical University, Wroclaw, Poland Abstract Introduction: Multiple endocrine neoplasia type 1 (MEN1) has been causing problems for clinicians since it was first described in 1954 by ORIGINAL PAPER Wermer. Not only its rarity, but also its variable clinical manifestations and lack of genotype-phenotype correlation make it hard to establish evidence-based guidelines for the management of this syndrome. Nationwide registers and population-based research are the best means to improve knowledge about this rare disease. As yet, there is no example of such research in the Polish population of MEN1 patients. Material and methods: We performed a retrospective analysis of clinical and genetic data of patients diagnosed with MEN1 syndrome and followed-up in two polish referral centres in the years 1994–2018. Results: We analysed 79 patients, of whom the majority were women. The mean age of the patient population was 43 years, mean age at MEN1 diagnosis was 37.95 years, and mean interval from initial symptoms to MEN1 diagnosis was 6.93 years. Primary hyperparathyroid- ism (PHP), gastroenteropancreatic neuroendocrine tumour (GEP-NET), and pituitary adenoma (PA) developed in 90%, 52%, and 47% of patients, respectively.
    [Show full text]
  • Treatment Options for Pancreatic Neuroendocrine Tumors
    cancers Review Treatment Options for Pancreatic Neuroendocrine Tumors Amit Akirov 1,2,3,* , Vincent Larouche 3,4, Sameerah Alshehri 3, Sylvia L. Asa 5 and Shereen Ezzat 3 1 Institute of Endocrinology, Beilinson Hospital, Petach Tikva 49100, Israel 2 Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel 3 Department of Endocrine Oncology, Princess Margaret Cancer Centre, Toronto, ON M5G 1Z5, Canada; [email protected] (V.L.); [email protected] (S.A.); [email protected] (S.E.) 4 Department of Medicine, Division of Endocrinology and Metabolism, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada 5 Department of Pathology, University Health Network, University of Toronto, Toronto, ON M5S 1A1, Canada; [email protected] * Correspondence: [email protected]; Tel.: +972-524650760; Fax: +972-3-9377181 Received: 24 May 2019; Accepted: 12 June 2019; Published: 14 June 2019 Abstract: The management of pancreatic neuroendocrine tumors (PanNETs) involves classification into non-functional or functional PanNET, and as localized or metastatic PanNET. In addition, while most PanNETs are sporadic, these endocrine neoplasms can also be manifestations of genetic syndromes. All these factors may assist in forming a risk stratification system permitting a tailored management approach. Most PanNETs are classified as non-functional because they are not associated with clinical sequelae of hormone excess. They are characterized by non-specific symptoms, such as abdominal pain or weight loss, resulting from mass effect related to the pancreatic tumor or secondary to distant metastases. Accurate staging of the disease is essential for determining the appropriate approach to therapy. As cure is only potentially possible with surgical resection of the tumor, it is recommended to remove all localized and limited metastatic disease.
    [Show full text]
  • Cancers of the Endocrine Organs – Endocrine Neoplasms Preferred Model of Care and Criteria for Reference Centres
    CANCERS OF THE ENDOCRINE ORGANS – ENDOCRINE NEOPLASMS PREFERRED MODEL OF CARE AND CRITERIA FOR REFERENCE CENTRES Coordinators: Giuseppe COSTANTE (Endocrinology, Institut Jules Bordet), Ahmad AWADA (Medical oncology, Institut Jules Bordet). Authors : Giuseppe COSTANTE (Endocrinology, Institut Jules Bordet), Kris POPPE (Endocrinology, VUB), Laurent VROONEN (Endocrinology, CHU Liège), Bruno LAPAUW (Endocrinology, UZ Gent), Isabelle SALMON (Pathology, Erasme), Guy ANDRY (Head and neck surgery, Institut Jules Bordet), Ahmad AWADA (Medical oncology, Institut Jules Bordet). Disclaimer : The coordinators of the working groups and all the authors listed by chapter have worked autonomously under the supervision of the KCE team. The KCE experts are not co-authors of these proposals and did not necessarily validate their content. Hospitals with which coordinators and authors of these proposals are affiliated are not de facto considered Reference Centres. Similarly, Belgian hospitals that are not represented in these proposals are not de facto considered Peripheral Centres. These proposals were not submitted to the external validators. This addendum only exists in English. No French or Dutch translation was done. Finally, the report to which this addendum refers has been approved by common assent by the Executive Board. Copyright : KCE reports are published under a “by/nc/nd” Creative Commons Licence http://kce.fgov.be/content/about-copyrights-for-kce-reports. This section is part of a whole document (KCE Report 219 Addendum) available on the
    [Show full text]
  • Tumours Producing Hypoglycaemia
    Endocrine-Related Cancer (1998) 5 111-129 Tumours producing hypoglycaemia V Marks and J D Teale European Institute of Health and Medical Sciences, University of Surrey, Guildford GU2 5RF, UK and Department of Clinical Biochemistry and Nutrition, Royal Surrey County Hospital, Guildford GU2 5XX, UK (Requests for offprints should be addressed to V Marks) Introduction Classification of hypoglycaemia- Hypoglycaemia is one of the commonest of medical producing tumours emergencies, mainly due to its high frequency as a Tumours producing hypoglycaemia can, broadly complication of insulin therapy of diabetes. It sometimes speaking, be divided - on the basis of the mechanism by arises, however, ‘spontaneously’ as a manifestation of which they most commonly produce hypoglycaemia - other diseases. The present review deals exclusively with into: (1) insulin-secreting tumours; (2) non-islet cell hypoglycaemia caused by neoplastic disease. (insulin-like growth factor-II (IGF-II)-secreting) tumours; For a very brief period, between 1927 and 1930, (3) myeloma, lymphoma and leukaemia; and (4) meta- tumours capable of producing hypoglycaemia were static neoplasia. thought always to secrete insulin and arise exclusively Hypoglycaemia produced by tumours other than within the pancreas. In the intervening years it has become insulinomas is usually referred to as ‘non-islet cell tumour increasingly apparent that almost any type of neoplasm hypoglycaemia’ (NICTH) and has more than one cause. can cause hypoglycaemia through a number of different mechanisms (Marks & Rose 1964, Laurent et al. 1971, Pancreatic endocrine tumours Daughaday 1989, Fajans & Vinik 1989). Insulin-secreting tumours are the commonest hormone- producing neoplasms of the gastrointestinal tract. They Symptomatology occur with an incidence of between 0.5 and 1 per million of the population per year (Kavlie & White 1972, Hypoglycaemia may be the presenting symptom of a Atkinson et al.
    [Show full text]