Opening New Horizons for Scientific Research
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And Should Not, Change Toxic Tort Causation Doctrine
THE MORE WE KNOW, THE LESS INTELLIGENT WE ARE? - HOW GENOMIC INFORMATION SHOULD, AND SHOULD NOT, CHANGE TOXIC TORT CAUSATION DOCTRINE Steve C. Gold* Advances in genomic science are rapidly increasing our understanding of dis- ease and toxicity at the most fundamental biological level. Some say this heralds a new era of certainty in linking toxic substances to human illness in the courtroom. Others are skeptical. In this Article I argue that the new sciences of molecular epidemiology and toxicogenomics will evince both remarkable explanatory power and intractable complexity. Therefore, even when these sciences are brought to bear, toxic tort claims will continue to present their familiar jurisprudential problems. Nevertheless, as genomic information is used in toxic tort cases, the sci- entific developments will offer courts an opportunity to correct mistakes of the past. Courts will miss those opportunities, however, if they simply transfer attitudesfrom classical epidemiology and toxicology to molecular and genomic knowledge. Using the possible link between trichloroethyleneand a type of kidney cancer as an exam- ple, I describe several causation issues where courts can, if they choose, improve doctrine by properly understanding and utilizing genomic information. L Introduction ............................................... 370 II. Causation in Toxic Torts Before Genomics ................... 371 A. The Problem .......................................... 371 B. Classical Sources of Causation Evidence ................ 372 C. The Courts Embrace Epidemiology - Perhaps Too Tightly ................................................ 374 D. Evidence Meets Substance: Keepers of the Gate ......... 379 E. The Opposing Tendency ................................ 382 III. Genomics, Toxicogenomics, and Molecular Epidemiology: The M ore We Know ........................................ 383 A. Genetic Variability and "Background" Risk .............. 384 B. Genetic Variability and Exposure Risk ................... 389 C. -
Dean, School of Science
Dean, School of Science School of Science faculty members seek to answer fundamental questions about nature ranging in scope from the microscopic—where a neuroscientist might isolate the electrical activity of a single neuron—to the telescopic—where an astrophysicist might scan hundreds of thousands of stars to find Earth-like planets in their orbits. Their research will bring us a better understanding of the nature of our universe, and will help us address major challenges to improving and sustaining our quality of life, such as developing viable resources of renewable energy or unravelling the complex mechanics of Alzheimer’s and other diseases of the aging brain. These profound and important questions often require collaborations across departments or schools. At the School of Science, such boundaries do not prevent people from working together; our faculty cross such boundaries as easily as they walk across the invisible boundary between one building and another in our campus’s interconnected buildings. Collaborations across School and department lines are facilitated by affiliations with MIT’s numerous laboratories, centers, and institutes, such as the Institute for Data, Systems, and Society, as well as through participation in interdisciplinary initiatives, such as the Aging Brain Initiative or the Transiting Exoplanet Survey Satellite. Our faculty’s commitment to teaching and mentorship, like their research, is not constrained by lines between schools or departments. School of Science faculty teach General Institute Requirement subjects in biology, chemistry, mathematics, and physics that provide the conceptual foundation of every undergraduate student’s education at MIT. The School faculty solidify cross-disciplinary connections through participation in graduate programs established in collaboration with School of Engineering, such as the programs in biophysics, microbiology, or molecular and cellular neuroscience. -
Stable Isotope Fingerprinting: a Novel Method for Identifying Plant, Fungal
Ecology, 00(0), 0000, pp. 000–000 Ó 0000 by the Ecological Society of America Stable isotope fingerprinting: a novel method for identifying plant, fungal, or bacterial origins of amino acids 1 THOMAS LARSEN,D.LEE TAYLOR,MARY BETH LEIGH, AND DIANE M. O’BRIEN Institute of Arctic Biology and Department of Biology and Wildlife, University of Alaska, Fairbanks, Alaska 99775-7000 USA Abstract. Amino acids play an important role in ecology as essential nutrients for animals and as currencies in symbiotic associations. Here we present a new approach to tracing the origins of amino acids by identifying unique patterns of carbon isotope signatures generated by amino acid synthesis in plants, fungi, and bacteria (‘‘13C fingerprints’’). We measured 13 amino acid d C from 10 C3 plants, 13 fungi, and 10 bacteria collected and isolated from a boreal forest in interior Alaska, USA, using gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS). Microorganisms were cultured under amino-acid-free conditions and identified based on DNA sequences. Bacteria, fungi, and plants generated consistent, unique 13C fingerprints based on the more complex amino acids (five or more biosynthetic steps) that are classified as essential for animals. Linear discriminant analysis classified all samples correctly with .99% certainty and correctly classified nearly all insect samples from a previous study by diet. Our results suggest that 13C fingerprints of amino acids could provide a powerful in situ assay of the biosynthetic sources of amino acids and a potential new tool for understanding nutritional linkages in food webs. Key words: Alaska, USA; compound-specific stable isotope analysis; d13C; essential amino acids; eukaryotes; gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS); prokaryotes. -
Table of Contents
AAS Newsletter September/October 2012, Issue 166 - Published for the Members of the American Astronomical Society Table of Contents 2 President’s Column 17 Committee on the Status of Women in 4 From the Executive Office Astronomy 5 What Makes an Astronomy Story 18 News from NSF Division of Astronomical Newsworthy? Sciences (AST) 6 Journals Update 20 JWST Update 9 Secretary's Corner 21 HAD News 9 Council Actions 21 Honored Elsewhere 10 The AAS Heeds the Call of the Wild 22 Announcements 16 Committee on Employment 23 Calendar of Events 25 Washington News A A S American Astronomical Society AAS Officers President's Column David J. Helfand, President Debra M. Elmegreen, Past President David J. Helfand, [email protected] Nicholas B. Suntzeff, Vice-President Edward B. Churchwell, Vice-President Paula Szkody, Vice-President Hervey (Peter) Stockman, Treasurer G. Fritz Benedict, Secretary Anne P. Cowley, Publications Board Chair Edward E. Prather, Education Officer At 1:32AM Eastern time on 6 Councilors August, the Mars Science Laboratory Bruce Balick Nancy S. Brickhouse and its charmingly named rover, Eileen D. Friel Curiosity, executed a perfect landing Edward F. Guinan Todd J. Henry in Gale Crater. President Obama Steven D. Kawaler called the highly complex landing Patricia Knezek Robert Mathieu procedure “an unprecedented feat of Angela Speck technology that will stand as a point Executive Office Staff of pride far into the future.” While Kevin B. Marvel, Executive Officer we certainly hope Curiosity’s lifetime Tracy Beale, Registrar & Meeting Coordinator Chris Biemesderfer, Director of Publishing on Mars is a long one, we must all Sherri Brown, Membership Services continue to make the case that we Coordinator Kelly E. -
Precision Medicine Initiative: Building a Large US Research Cohort
Precision Medicine Initiative: Building a Large U.S. Research Cohort February 11-12, 2015 PARTICIPANT LIST Goncalo Abecasis, D. Phil. Philip Bourne, Ph.D. Professor of Biostatistics Associate Director for Data Science University of Michigan, Ann Arbor Office of the Director National Institutes of Health Christopher Austin, M.D. Director Murray Brilliant, Ph.D. National Center for Advancing Translational Sciences Director National Institutes of Health Center for Human Genetics Marshfield Clinic Research Foundation Vikram Bajaj, Ph.D. Chief Scientist Greg Burke, M.D., M.Sc. Google Life Sciences Professor and Director Wake Forest School of Medicine Dixie Baker, Ph.D. Wake Forest University Senior Partner Martin, Blanck and Associates Antonia Calafat, Ph.D. Chief Dana Boyd Barr, Ph.D. Organic Analytical Toxicology Branch Professor, Exposure Science and Environmental Health Centers for Disease Control and Prevention Rollins School of Public Health Emory University Robert Califf, M.D. Vice Chancellor for Clinical and Translational Research Jonathan Bingham, M.B.A. Duke University Medical Center Product Manager, Genomics Google, Inc. Rex Chisholm, Ph.D. Adam and Richard T. Lind Professor of Medical Eric Boerwinkle, Ph.D. Genetics Professor and Chair Vice Dean for Scientific Affairs and Graduate Studies Human Genetics Center Associate Vice President for Research University of Texas Health Science Center Northwestern University Associate Director Human Genome Sequencing Center Rick Cnossen, M.S. Baylor College of Medicine Director Global Healthcare Solutions Erwin Bottinger, M.D. HIMSS Board of Directors Professor PCHA/Continua Health Alliance Board of Directors The Charles Bronfman Institute for Personalized Intel Corporation Medicine Icahn School of Medicine at Mount Sinai - 1 - Francis Collins, M.D., Ph.D. -
Count Down: Six Kids Vie for Glory at the World's Toughest Math
Count Down Six Kids Vie for Glory | at the World's TOUGHEST MATH COMPETITION STEVE OLSON author of MAPPING HUMAN HISTORY, National Book Award finalist $Z4- 00 ACH SUMMER SIX MATH WHIZZES selected from nearly a half million EAmerican teens compete against the world's best problem solvers at the Interna• tional Mathematical Olympiad. Steve Olson, whose Mapping Human History was a Na• tional Book Award finalist, follows the members of a U.S. team from their intense tryouts to the Olympiad's nail-biting final rounds to discover not only what drives these extraordinary kids but what makes them both unique and typical. In the process he provides fascinating insights into the creative process, human intelligence and learning, and the nature of genius. Brilliant, but defying all the math-nerd stereotypes, these athletes of the mind want to excel at whatever piques their cu• riosity, and they are curious about almost everything — music, games, politics, sports, literature. One team member is ardent about water polo and creative writing. An• other plays four musical instruments. For fun and entertainment during breaks, the Olympians invent games of mind-boggling difficulty. Though driven by the glory of winning this ultimate math contest, in many ways these kids are not so different from other teenagers, finding pure joy in indulging their personal passions. Beyond the Olympiad, Steve Olson sheds light on such questions as why Americans feel so queasy about math, why so few girls compete in the subject, and whether or not talent is innate. Inside the cavernous gym where the competition takes place, Count Down reveals a fascinating subculture and its engaging, driven inhabitants. -
CV Seth Newsome.Pdf
Seth D. Newsome University of New Mexico Associate Professor, Department of Biology Associate Director, Center for Stable Isotopes 190 Castetter Hall Albuquerque, NM 87131 USA [email protected] http://sethnewsome.org Research Interests Animal Ecology, Animal Eco-Physiology, Historical Ecology, Conservation Biology Education 2000–2005 Ph.D., University of California Santa Cruz (Santa Cruz, CA) Earth & Planetary Sciences Department 1995–1999 B.A., Dartmouth College (Hanover, NH) Earth Sciences Department Positions & Professional Development 2018– Associate Professor, Biology Department, University of New Mexico (Albuquerque, NM) 2014– Associate Director, University of New Mexico Center for Stable Isotopes 2013–2018 Assistant Professor, Biology Department, University of New Mexico (Albuquerque, NM) 2009–2012 Post-Doctoral Research Scientist, University of Wyoming (Laramie, WY) Research focused on (1) using compound specific stable isotope analysis to quantify protein routing in mammals, birds and fish; (2) characterizing the ecology of an adaptive radiation in a group of South American songbirds via biochemical, physiological, and genetic tools. Advisors: Drs. Carlos Martinez del Rio and David G. Williams 2006–2009 Post-Doctoral Research Scientist, Carnegie Institution of Washington (Washington, DC) Research focused on (1) development of stable isotope methods to assess ecological niche and eco-physiological variation, foraging specialization, and dispersal characteristics of mammals and birds; (2) human impacts on ecosystem change in Australia and southern California. Advisor: Dr. Marilyn L. Fogel 2000–2005 Ph.D. Candidate, UC-Santa Cruz (Santa Cruz, CA) Research focused on historic and prehistoric ecology of marine mammals, with emphasis on the northern fur seal in the northeast Pacific Ocean. Advisor: Dr. Paul L. Koch 2000 Senior Lab Technician, Lawrence Berkeley National Laboratory (Berkeley, CA) Managed stable isotope facility and conducted research using isotopic tracers to track fluid and contaminant migration through sediments and groundwater. -
Interview with Melvin I. Simon
MELVIN I. SIMON (b. 1937) INTERVIEWED BY SHIRLEY K. COHEN May 24 and June 5, 2005 Melvin I. Simon ARCHIVES CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, California Subject area Biology Abstract Interview in two sessions, May 24 and June 5, 2005, with Melvin I. Simon, Anne P. and Benjamin F. Biaggini Professor of Biological Sciences, emeritus, in the Division of Biology. Dr. Simon received his BS from City College of New York in 1959 and his PhD in biochemistry from Brandeis in 1963. After receiving his degree, he was a postdoctoral fellow with Arthur Pardee at Princeton for a year and a half and then joined the faculty of the University of California at San Diego. In 1978, Dr. Simon and his UCSD colleague John Abelson established the Agouron Institute in San Diego, focusing on problems in molecular biology. He (along with Abelson) joined the faculty of Caltech as a full professor in 1982, and he served as chair of the Biology Division from 1995 to 2000. http://resolver.caltech.edu/CaltechOH:OH_Simon_M In this interview, he discusses his education in Manhattan’s Yeshiva High School (where science courses were taught by teachers from the Bronx High School of Science), at CCNY, and as a Brandeis graduate student working working with Helen Van Vunakis on bacteriophage. Recalls his unsatisfactory postdoc experience at Princeton and his delight at arriving at UC San Diego, where molecular biology was just getting started. Discusses his work on bacterial organelles; recalls his and Abelson’s vain efforts to get UCSD to back a full-scale initiative in molecular biology and their subsequent founding of their own institute. -
Boston, Cambridge Are Ground Zero for Life Sciences
OPINION | JUAN ENRIQUEZ Boston, Cambridge are ground zero for life sciences BOYDEN PHOTO BY DOMINICK REUTER; LINDQUIST BY JOHN SOARES/WHITEHEAD INSTITUTE; GLOBE STAFF PHOTOS Top row: Robert Langer, Jack Szostak, and George Church. Bottom: Susan Lindquist and Edward S. Boyden. MARCH 16, 2015 BOSTONCAMBRIDGE is ground zero for the development and deployment of many of the bleeding edge life science discoveries and technologies. One corner alone, Vassar and Main Street in Cambridge, will likely generate 1 to 2 percent of the future world GDP. On a per capitSah baraesis, nowhere else coTmweese tclose in terms o3f Creomsemaerncths grants, patents, and publications that drive new gene code, which in turn alters the evolution of bacteria, plants, animals, and ourselves. CONTINUE READING BELOW ▼ At MIT, Bob Langer is generating the equivalent of a small country’s economy out of a single lab; his more than 1,080 patents have helped launch or enabled more than 300 pharma, chemical, biotech, and medical device companies. At Harvard, George Whitesides’ 12 companies have generated a market capitalization of over $20 billion. Harvard Med’s resident geniusenfant terrible, George Church, is the brains behind dozens and dozens of successful startups. (All this of course in addition to these folks being at the very top of their academic fields). In terms of the most basic questions about life itself, Ting Wu takes billions of lines of gene code across all organisms and meticulously compares each and every gene, looking for highly conserved gene code. She is narrowing in on exactly what DNA sequences are essential to all life forms, from bacteria through plants, animals, and even politicians. -
Effect of Cover Crop on Carbon Distribution in Size and Density
Article Effect of Cover Crop on Carbon Distribution in Size and Density Separated Soil Aggregates Michael V. Schaefer 1,2 , Nathaniel A. Bogie 3,4 , Daniel Rath 5, Alison R. Marklein 1,6, Abdi Garniwan 1, Thomas Haensel 1, Ying Lin 7, Claudia C. Avila 1 , Peter S. Nico 6, Kate M. Scow 5,8, Eoin L. Brodie 6,9, William J. Riley 6 , Marilyn L. Fogel 7,10, Asmeret Asefaw Berhe 3 , Teamrat A. Ghezzehei 3, Sanjai Parikh 5 , Marco Keiluweit 11 and Samantha C. Ying 1,12,* 1 Department of Environmental Sciences, University of California, Riverside, CA 92521; USA; [email protected] (M.V.S.); [email protected] (A.R.M.); [email protected] (A.G.); [email protected] (T.H.); [email protected] (C.C.A.) 2 Pacific Basin Research Center, Soka University of America, Laguna Hills, CA 92656, USA 3 Environmental System, University of California, Merced, CA 95343, USA; [email protected] (N.A.B.); [email protected] (A.A.B.); [email protected] (T.A.G.) 4 Geology Department, San Jose State University, San Jose, CA 95192, USA 5 Department of Land, Air, and Water Resource, University of California, Davis, CA 95616, USA; [email protected] (D.R.); [email protected] (K.M.S.); [email protected] (S.P.) 6 Earth and Environmental Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; [email protected] (P.S.N.); [email protected] (E.L.B.); [email protected] (W.J.R.) 7 Environmental Dynamics and GeoEcology Institute, University of California, Riverside, CA 92521, USA; [email protected] (Y.L.); [email protected] (M.L.F.) 8 Agricultural -
NASA Astrobiology Institute 2018 Annual Science Report
A National Aeronautics and Space Administration 2018 Annual Science Report Table of Contents 2018 at the NAI 1 NAI 2018 Teams 2 2018 Team Reports The Evolution of Prebiotic Chemical Complexity and the Organic Inventory 6 of Protoplanetary Disk and Primordial Planets Lead Institution: NASA Ames Research Center Reliving the Past: Experimental Evolution of Major Transitions 18 Lead Institution: Georgia Institute of Technology Origin and Evolution of Organics and Water in Planetary Systems 34 Lead Institution: NASA Goddard Space Flight Center Icy Worlds: Astrobiology at the Water-Rock Interface and Beyond 46 Lead Institution: NASA Jet Propulsion Laboratory Habitability of Hydrocarbon Worlds: Titan and Beyond 60 Lead Institution: NASA Jet Propulsion Laboratory The Origins of Molecules in Diverse Space and Planetary Environments 72 and Their Intramolecular Isotope Signatures Lead Institution: Pennsylvania State University ENIGMA: Evolution of Nanomachines in Geospheres and Microbial Ancestors 80 Lead Institution: Rutgers University Changing Planetary Environments and the Fingerprints of Life 88 Lead Institution: SETI Institute Alternative Earths 100 Lead Institution: University of California, Riverside Rock Powered Life 120 Lead Institution: University of Colorado Boulder NASA Astrobiology Institute iii Annual Report 2018 2018 at the NAI In 2018, the NASA Astrobiology Program announced a plan to transition to a new structure of Research Coordination Networks, RCNs, and simultaneously planned the termination of the NASA Astrobiology Institute -
Probes of Cosmological Structure and Galaxy Evolution Edited by John S
Cambridge University Press 978-0-521-14352-3 - Clusters of Galaxies: Probes of Cosmological Structure and Galaxy Evolution Edited by John S. Mulchaey, Alan Dressler and Augustus Oemler Frontmatter More information Clusters of Galaxies Probes of Cosmological Structure and Galaxy Evolution Clusters of galaxies are the largest and most massive collapsed systems in the universe, and as such they are valuable probes of cosmological structure and galaxy evolution. The advent of extensive galaxy surveys, large ground-based facilities, space-based missions such as HST, Chandra,andXMM-Newton and detailed numerical simulations makes now a particularly exciting time to be involved in this field. The review papers in this volume span the full range of current research in this area, including theoretical expectations for the growth of structure, survey techniques to identify clusters, metal production and the intracluster medium, galaxy evolution in the cluster environment and group–cluster connections. With contributions from leading authorities in the field, this volume is appropriate both as an introduction to this topic for physics and astronomy graduate students, and as a reference source for professional research astronomers. JOHN S. MULCHAEY’s research has focused on groups of galaxies. In 1993, he provided some of the strongest evidence to date that galaxy groups are dominated by dark matter. More recently he has played an important role in the discovery and study of “fossil groups,” massive systems that contain very few galaxies. ALAN DRESSLER has made many fundamental contributions to the study of large-scale structure in the Universe over the last 30 years. Recently, he participated in the MORPHS project, using Hubble Space Telescope images to show that bursts of star formation were much more common in galaxies 5 billion years ago than they are today.