ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005

Volume 29, Number 1, January 2009 Experimental Studies

Contents

Bortezomib Therapeutic Effect is Associated with Expression of FGFR3 in Multiple Myeloma Cells. M. GUAN, L. ZHU, G. SOMLO, A. HUGHES, B. ZHOU, Y. YEN (Duarte, CA, USA; Zhejiang, China)...... 1

Utilization of a Right-handed Coiled-coil Protein from Archaebacterium Staphylothermus marinus as a Carrier for Cisplatin. M. ERIKSSON, S. HASSAN, R. LARSSON, S. LINDER, T. RAMQVIST, H. LÖVBORG, T. VIKINGE, E. FIGGEMEIER, J. MÜLLER, J. STETEFELD, T. DALIANIS, S. ÖZBEK (Stockholm; Uppsala; Linköping, Sweden; Basel, Switzerland; Winnipeg, Manitoba, Canada; Heidelberg, Germany)...... 11

Gene Amplification of Myc and its Coamplification with ERBB2 and EGFR in Gallbladder Adenocarcinoma. A. OOI, S. SUZUKI, K. NAKAZAWA, J. ITAKURA, I. IMOTO, H. NAKAMURA, Y. DOBASHI (Ιshikawa; Yamanishi; Tokyo; Saitama, Japan) ...... 19

Effect of Verapamil on the Expression of EGFR and NM23 in A549 Human Lung Cancer Cells. C. ZHANG, F. LV, L. ZHOU, X. LI, X.-X. WU, R.M. HOFFMAN (Harbin; Qiqihaer, China; Kagawa, Japan; San Diego, CA, USA) ...... 27

Antioxidant Effects of Quercetin and Coenzyme Q10 in Mini Organ Cultures of Human Nasal Mucosa Cells. M. REITER, K. RUPP, P. BAUMEISTER, S. ZIEGER, U. HARRÉUS (Munich, Germany) ...... 33

Distinct Patient Responses to Activation of T-cells by Free HER-2, G89 (777-789) and Protected LRMK-linked HER-2, {AE-39 [p776 (Ava-774-788)], AE-47 [(Ava-776-788)] and AE-37[p776 (774-788)]} Peptides Could Lead to Development of Personalized Cancer Vaccines. Y. LI, S. MATSUEDA, C.L. EFFERSON, N. TSUDA, K. KAWANO, H. GAO, G.E. PEOPLES, C.G. IOANNIDES (Houston; San Antonio, TX, USA) ...... 41

Contents continued on the back cover ANTICANCER RESEARCH International Journal of Cancer Research and Treatment

ISSN: 0250-7005

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KOTTARIDIS, Athens, Greece Production Editor ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005

VOLUME 29 2009 ANTICANCER RESEARCH 29: (2009)

Editorial Board

B. B. Aggarwal Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA J. P. Armand Institut Gustav-Roussy, Villejuif, France D. Assimakopoulos Department of Otorhinolaryngology, Medical School, University of Ioannina, Greece V. I. Avramis Division of Hematology/Oncology, Childrens Hospital, Los Angeles, CA, USA R. C. Bast Department of Translational Research, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA G. Bauer Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Germany E. E. Baulieu INSERM U488 and College de France, Le Kremlin-Bicetre, France Y. Becker Department of Molecular Virology, Hebrew University of Jerusalem, Israel E. J. Benz, Jr. Dana-Farber Cancer Institute, Boston, MA, USA J. Bergh Department of Clinical and Molecular Medicine, Radiumhemmet, Karolinska Institute, Stockholm, Sweden J. L. Biedler Department of Biological Sciences, Fordham University, Bronx, NY, USA D. D. Bigner Department of Pathology, Duke University Medical Center, Durham, NC, USA A. Böcking Institute for Cytopathology, University of Düsseldorf, Germany G. Bonadonna Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy F. T. Bosman Institute of Pathology, University of Lausanne, Switzerland G. Broich ASL Lodi, Lodi, Italy J. M. Brown Department of Radiation Oncology, Stanford Medical Center, Stanford, CA, USA Ø. S. Bruland Department of Medical Oncology-Radiotherapy, Norwegian Radium Hospital, Oslo, Norway M. M. Burger Novartis, Basel, Switzerland M. Carbone Cancer Research Center of Hawaii, Honolulu, HI, USA J. Carlsson Department of Biomedical Radiation Sciences, Uppsala University, Sweden A. F. Chambers Department of Oncology, London Regional Cancer Center, London, Ontario, Canada P. Chandra Abt. für Molekularbiologie, Klinikum Wolfgang Goethe-Universität, Frankfurt am Main, Germany L. Cheng Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA J.-G. Chung Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, ROC E. De Clercq Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium W. De Loecker Department of , Katholieke Universiteit Leuven, Belgium W. Den Otter VUMC, Department of Urology, Amsterdam, The Netherlands E. P. Diamandis Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada G. Th. Diamandopoulos Department of Pathology, Harvard Medical School, Boston, MA, USA W. Ebert Thoraxclinic HD-Rohrbach, Heidelberg, Germany U. Eppenberger Laboratory of Biochemistry/Endocrinology, University Clinic, Basel, Switzerland J. A. Fernandez-Pol Metalloproteomics, LLC, Chesterfield, MO, USA I. J. Fidler Department of Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA W. Fiers Department of Molecular Biomedical Research, Ghent University and VIB, Belgium N. E. Fusenig Division of Differentiation, DKFZ, Heidelberg, Germany G. Gabbiani Department of Pathology, University of Geneva, Switzerland A. F. Gazdar Hamon Center for Therapeutic Oncology Research, University of Texas Southeastern Medical Center, Dallas, TX, USA A. Giordano Sbarro Institute for Cancer Research, Temple University, Philadelphia, PA, USA G. Gitsch Department of Gynecology and Obstetrics, University of Freiburg, Germany R. H. Goldfarb Sopherion Therapeutics, Inc., Princeton, NJ, USA J. W. Gorrod Unit, John Tabor Laboratories, University of Essex, Colchester, Essex, UK S. Hammarstro¨m Department of Immunology, University of Umea¨, Sweden I. Hart Centre for Tumour Biology, Institute of Cancer and CR-UK Clinical Centre, Bart’s and The London, Queen Mary’s School of Medicine and Dentistry, London, UK

continued ANTICANCER RESEARCH 29: (2009)

I. Hellstro¨m Harborview Medical Center, Seattle, WA, USA L. Helson Department of Experimental Therapeutics, New York Medical College, Valhalla, NY, USA R. B. Herberman Pittsburgh Cancer Institute, Pittsburgh, PA, USA R. M. Hoffman Department of Surgery, University of California, San Diego, CA, USA C. G. Ioannides Department of Gynecology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA S. C. Jhanwar Laboratory of Solid Tumor Genetics, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA J. V. Johannessen Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway B. Kaina Institute of Toxicology, University of Mainz, Germany B. K. Keppler School of Medicine, University of Vienna, Austria D. G. Kieback Department of Obstetrics and Gynecology, HELIOS Medical Center, Carl Gustav Carus University Dresden, Germany J. Kieler Danish Cancer Society, Copenhagen, Denmark R. Klapdor Medical Clinic, University of Hamburg, Germany U. R. Kleeberg Hämatologisch - Onkologisch - Praxis Altona, Hamburg, Germany P. Kleihues Department of Pathology, University Hospital Zürich, Switzerland E. Klein Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden S. von Kleist Institut für Immunologie der Universität der Freiburg, Germany S. D. Kottaridis Department of Virology, Hellenic Anticancer Institute, Athens, Greece G. R. F. Krueger Center of Anatomy II, University of Cologne Medical School, Cologne, Germany D. W. Kufe Division of Medicine, Dana-Farber Cancer Institute, Boston, MA, USA Pat Kumar Department of Biological Sciences, Manchester Metropolitan University, Manchester, UK Shant Kumar Department Pathology, University of Manchester Medical School, Manchester, UK M. Kuroki Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka, Japan O. D. Laerum Department of Pathology, The Gade Institute, University of Bergen, Norway F. J. Lejeune Fondation du Centre Pluridisciplinaire d' Oncologie, CHUV, Lausanne, Switzerland C. J. Link Iowa Cancer Research Foundation, Clive, IA, USA L. A. Liotta Center of Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA L. F. Liu Department of Pharmacology, UMD of New Jersey, Piscataway, NJ, USA D. M. Lopez Department of and Immunology, University of Miami School of Medicine, Miami, FL, USA E. Lundgren Unit of Applied Cell and , University of Umea¨, Sweden H. T. Lynch Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE, USA J. Marescaux IRCAD, University of Strasbourg, France J. Mark Department of Pathology, Kärnsjukhuset, Skövde, Sweden J. F. Marshall Centre for Tumour Biology, Institute of Cancer and CR-UK Clinical Centre, Bart’s and The London, Queen Mary’s School of Medicine and Dentistry, London, UK D. Medina Department of , Baylor College of Medicine, Houston, TX, USA S. Mitra Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX, USA F. M. Muggia New York University Cancer Institute, School of Medicine, NY, USA M. J. Murphy, Jr. Hipple Cancer Research Center, Dayton, OH, USA R. Narayanan Department of Biological Sciences, Florida Atlantic University, Boca Raton, FL, USA K. Nilsson Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University Hospital, Sweden J. F. Novak Department of Biology, Bucknell University, Lewisburg, PA, USA S. Pathak Department of Cell Biology, University of Texas, Houston, TX, USA S. Pestka Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA G. J. Pilkington Department of Cellular and Molecules Neurooncology, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK C. D. Platsoucas College of Sciences, Old Dominion University, Norfolk, VA, USA

continued ANTICANCER RESEARCH 29: (2009)

F. Podo Laboratory of Cell Biology, Istituto Superione di Sanita` , Rome, Italy A. Polliack Department of Haematology, Hadassah University Hospital and Medical School, Jerusalem, Israel M. F. Rajewsky Institute of Cell Biology, University of Essen Medical School, Essen, Germany G. Rebel IRCAD, Hopitaux Universitaires, Strasbourg, France M. Rigaud Laboratory Biochimie et Génétique Molecules, Faculté de Médecine de Limoges, France U. Ringborg Department of General Oncology, Karolinska Hospital, Stockholm, Sweden M. Roselli Department of Medical Oncology, University of Rome “Tor Vergata”, Italy A. Schauer Zentrum Pathologie, Georg-August Universität, Göttingen, Germany M. Schneider Department of Organic Chemistry, Bergische University, Wuppertal, Germany A. Seth Laboratory of Molecular Pathology, Sunnybrook Research Institute and University of Toronto, Ontario, Canada G. V. Sherbet Cancer Research Unit, University of Newcastle-upon-Tyne, UK G.-I. Soma Institute for Health Sciences, Tokushima Bunri University, Tokushima, Japan G. S. Stein Department of Cell Biology, University of Massachusetts Medical Center, Worcester, MA, USA T. Stigbrand Department of Immunology, Umea¨ University, Umea¨, Sweden K. Takagi Kennan Takagi Clinic, Kumamoto, Japan D. Tarin University of California at San Diego, Cancer Center, La Jolla, CA, USA G. B. de The’ Institut Pasteur, Paris, France T. M. Theophanides Department of Chemistry, Technical University of Athens, Greece B. Toth The Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE, USA E. Trell Department of General Practice and Primary Care, Faculty of Health Sciences, University of Linköping, Sweden P. M. Ueland Clinical Pharmacolocy Unit, Department of Pharmacology, University of Bergen, Norway P. T. Vihko Department of Clinical Chemistry, University of Oulu, Finland M. Volm German Cancer Research Center, Heidelberg, Germany G. Weber Laboratory of Experimental Oncology, Indiana University, Indianapolis, IN, USA I. B. Weinstein Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY, USA B. Westermark Rudbecklaboratoriet, Department of Genetics and Pathology, University of Uppsala, Sweden B. Zumoff Division of Endocrinology and Metabolism, Beth Israel Medical Center, New York, NY, USA