TARGET AUDIENCE PROGRAM REGISTRATION This conference is designed for medical, surgical and radiation Tuition: US$350 Physicians in Practice (prior to June 21, 2004) oncologists, as well as obstetricians, gynecologists and other US$400 Physicians (On/After June 21, 2004 & On-Site) physicians interested in leading edge information on breast US$200 Residents, Fellows, Nurses and Allied Health care and the most promising clinical trials for their breast Professionals cancer or high risk patients. US$130 Accompanying Person to Dinner Reception Tuition is complimentary for Patient Advocates / Cancer Survivors

EDUCATIONAL OBJECTIVES Tuition includes, admission to scientific sessions, a course syllabus, continental breakfast, refreshment breaks, a cocktail reception on Upon completion of this conference, participants should be able Thursday, July 22nd, and a dinner event on Friday, July 23rd, to: 2004. ‹ Understand the basic mechanisms of the development of , its natural history, risk factors, genetic There will be an additional $150 fee for each of the three Surgical component and prognostic indicators; Hands-On Sessions and $100 for the Nursing Seminar. It is required that attendees register for the entire conference in order to register ‹ Be up-to-date on today’s diagnostic and treatment for the surgical sessions and/or the luncheons. controversial areas of invasive and non-invasive breast cancer Refunds will be made only if written notice of cancellation is received care; prior to May 21, 2004. A $75 fee is charged for all refunds. After ‹ Guide patients to the ongoing clinical trials and develop May 21, 2004, no refunds will be made. In cases where a course novel treatment concepts for future clinical trials; is cancelled due to insufficient registrations, a full tuition refund is made. ‹ Become familiar with new breast cancer risk-assessment tools and risk reduction options; LANGUAGE/TRANSLATION ‹ Acquire “hands-on” education experience on new minimally The official language of the activity will be English with simultaneous invasive techniques; translation into Spanish provided for all lectures. ‹ Be informed of novel, molecular-targeted treatments that are Traducción simultanea al Español será proveída para las ready for the bedside and in early clinical development; conferencias. ‹ Create “bridges” networking among physicians from all over the world. CME ACCREDITATION The University of Miami School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. ABSTRACT INSTRUCTIONS The Deadline for all abstracts is June 21, 2004. CREDIT HOURS Mail Abstracts to the Division of Continuing Medical Education. This University of Miami School of Medicine designates this Abstract will also be accepted by email. continuing medical education activity for a maximum of 22.5 hours in category 1 credit towards the AMA Physician’s Recognition Participants with new data relevant to the subject of the conference Award (15 hours for general sessions; 2 hours for may submit abstracts to be considered for poster presentation. optional luncheons; and a maximum of 6 hours for optional surgical hands-on sessions). Each physician should Only papers whose abstracts have been reviewed and approved claim only those hours of credit that he/she actually spent in the by the Program Director will be presented. educational activity.

Abstracts must be written in English and the text should not exceed FACULTY DISCLOSURE 2000 characters (title included). The title should appear in capital The University of Miami School of Medicine, in accordance with letters. accreditation requirements, will disclose any significant financial interest or other relationship with the manufacturer(s) of any To request an Abstract Submission Form please mark the specified commercial products(s) and/or provider(s) of commercial services box on the Registration Form included in this brochure. discussed in an educational presentation and with any commercial supporters of the activity. Faculty are also required to disclose to Abstracts can be submitted electronically by logging on to the the audience any discussion of off-labeled or investigational use of UM CME website: http://cme.med.miami.edu. a product discussed during his/her presentation.

Abstracts will only be accepted from registered participants. FOR ADDITIONAL INFORMATION Division of Continuing Medical Education SERVICES FOR THE DISABLED University of Miami School of Medicine If special arrangements are required for an individual with a PO Box 016960(D23-3), Miami, Florida 33101-6960 disability to attend this conference, please contact the Division of Tel. 305-243-6716 / Fax: 305-243-5613 / Toll Free:1-800-U-of-M-CME CME at 305-243-6716, no later than by July 2, 2004. email: [email protected] http://www.cme.med.miami.edu PROGRAM AGENDA Wednesday, July 21, 2004 10:00- Investigators Meeting #1 - Eli Lilly and Company 12:30 Presentation of the First 1:00 Umberto Veronesi Award for the Future Fight Against Breast Cancer 2:00- Investigators Meeting #2 - Pfizer Pharmaceutical Presented by Umberto Veronesi, MD - Italy 5:00PM

3:00-8:00 PM 1:00 Luncheon (For Registered Attendees Only) Program Registration for Breast Cancer Patient Advocacy “How to Light the Fire” Speaker of the Susan G. Komen Breast Cancer Surgical “Hands on” Sessions and Foundation Nursing Seminar Adjuvant Therapy for Breast Cancer Case Presentations and Questions from the Audience Panel Experts: Rodrigo Arriagada, MD - Chile Thursday- July 22, 2004 Eli Avisar, MD - USA 7:00AM Registration, Continental Breakfast and Gabriel N. Hortobagyi, MD - USA Exhibits Hyman Muss, MD - USA Martine Piccart, MD, PhD - Belgium Dennis Salmon, MD - USA 8:00 Opening Remarks Patient Advocate Program Director, Orlando E. Silva, MD, JD - USA

Morning Session Chair: Martine Piccart, MD - Belgium SIMULTANEOUS MINI-SESSIONS Co-Chair: Joyce Slingerland, MD, PhD - USA Stefan Gluck, MD, PhD - USA 2:00 - 5:00 PM Simultaneous Surgical Hands-On Session 8:10AM High Risk Women - Assessing and Managing (Certificate will be provided. Registration limited Breast Cancer Risk on a first-come basis) Judy Garber, MD - USA Seminar: Sentinel Lymph Node Detection with Blue Dye and Gamma Probe 8:40 Management of High Risk Women • Sergio Rodriguez Cuevas, MD - Mexico Ramin Mirhashemi, MD - USA • Frederick Moffat, MD - USA 2:00 - 4:00 PM 9:10 Chemoprevention Update Simultaneous Nursing Seminar Hyman Muss, MD - USA (Certificate will be provided for Nursing CEU credits. Registration limited on a first-come basis)

9:40 Cell Cycle Regulators and Tamoxifen Resistance Joyce Slingerland, MD, PhD - USA 2:15 Break - Visit Exhibits

10:10 Coffee Break - Visit Exhibits Afternoon Session Chair: Jose Baselga, MD - Spain Co-Chairs: Jacques Bonneterre, MD - France Kathleen Pritchard, MD - Canada 10:40 Sentinel Lymph Node Biopsy of the Axilla and Internal Mammary Node. When and How? 2:30 Overview of Adjuvant Umberto Veronesi, MD - Italy Martine Piccart, MD, PhD

11:10 Targeted Therapies in Breast Cancer - Part I 3:00 Adjuvant Hormonal Therapy in the Treatment of Pre- Dennis Slamon, MD, PhD - USA And Post-Menopausal Breast Cancer Kathleen Pritchard, MD - Canada

11:45 Gabriel N. Hortobagyi’s Life Achievements Martine Piccart, MD, PhD - Belgium 3:30- Targeted Therapies in Breast Cancer - Part II 4:00 Jose Baselga, MD - Spain

12:00 KEYNOTE: “The Future of Breast Cancer, A Visionaries View” 6:00- Poster Session / Reception - Mexican Night Gabriel N. Hortobagyi, MD - USA 8:00PM Friday, July 23, 2004 7:00AM Registration, Continental Breakfast and Afternoon Session Chair:Edith Perez, MD - USA Exhibits Co-Chair: Rodrigo Arriagada, MD - Chile Jean-Marc A. Nabholtz, MD - France Morning Session Chair: Shou-Ching Tang, MD, PhD - USA Co-Chairs: Joseph Rosenblatt, MD - USA & 2:00 Hormonal Management of Metastatic Breast Cancer Stefano Zurrida, MD - Italy Edith Perez, MD - USA

8:00 Lifestyle, Epidemiology, Risk Factors Worldwide and 2:30 Chemotherapy in the Metastatic Setting Hormone Replacement Therapy in 2004 Jacques Bonneterre, MD, PhD - France John McLachlan PhD - USA 3:00 Novel Therapeutic Agents in the Treatment of Breast 8:30 Predictive and Prognostic Factors, Clinical and Cancer Therapeutic Implications Jean-Marc A. Nabholtz, MD - France Carmen R. Gomez-Fernandez, MD - USA 3:30- Chemotherapy in the Elderly 9:00 Fine Needle Aspiration Cytology in Breast Cancer in 4:00 Lodovico Balducci, MD - USA 2004 Merce Jorda, MD - USA 7:00 - Dinner Event - Beach Night 9:00PM 9:30 Screening and Diagnostic Imaging Luz Venta, MD - USA Saturday - July 24, 2004 10:00 Coffee Break - Visit Exhibits 7:00AM Registration, Continental Breakfast and Exhibits 10:30 DCIS with Particular Reference to Origin, Growth and Morning Session Chair: Carolyn Sartor, MD - USA Distribution of Breast Cancer Co-Chairs: Giovanni Rosti, MD - USA Eva Rubin, MD - USA Guido Tuveri, MD - Italy 8:00 New Imaging Techniques - Use of MRI & PET SCAN 11:00 Surgical Management of Invasive Breast Cancer and for Evaluation of Breast Cancer In Situ Breast Cancer Maria Victoria Velasquez, MD - USA Dido Franceschi, MD - USA 8:30 What is new in Radiation ? 11:30 The Effects of Migration and Evolution on Breast Cancer ELIOT, TARGiT and MAMMOSiTE Andrew Pecora, MD - USA Cristiane Takita, MD - USA

12:15 Luncheon (For Registered Attendees Only) 9:00 Angiogenesis, Anti-Angiogenesis, Apoptosis Psychosocial Issues in Breast Cancer and Apoptotic Markers in Breast Cancer Carlos Sandoval, MD - USA Shou-Ching Tang, MD, PhD - USA

Metastatic Breast Cancer Case Presentations and 9:30 Neoadjuvant Therapy in Breast Cancer Questions from the Audience Judith Hurley, MD - USA Panel Experts: Jose Baselga, MD - Spain Jacques Bonneterre, MD - France 10:00 Coffee Break - Visit Exhibits Eli Avisar, MD - USA Stefan Gluck, MD, PhD - USA 10:30 Indication for Post Mastectomy Radiation Therapy - Edith Perez, MD - USA LABC and Inflammatory Breast Cancer Kathleen Pritchard, MD - Canada Carolyn Sartor, MD - USA Carolyn Sartor, MD - USA Patient Advocate 11:00 Prophylactic Reconstruction Philip Blondeel, MD, PhD - Belgium 1:45 Break - Visit Exhibits 11:30 Neurologic Complications and Paraneoplastic Syndromes Associated with Breast Cancer 2:00 - 5:00 PM Deborah Heros, MD - USA Simultaneous Surgical Hands-On Session (Certificate will be provided. Registration limited on a 12:00 Management of Vasomotor Symptoms first come basis) Hyman Muss, MD - USA Seminar: Ductal Lavage and Ductal Endoscopy Robert Donaway, MD - USA 12:30 The Significance of Bone Marrow Micrometastases Sonia Maria Flores Moreno, MD - Mexico and the Importance of Bisphosphanate Therapy in the Adjuvant Setting 2:00 - 4:00 P.M. James Vredenburgh, MD - USA Simultaneous Nursing Seminar (Certificate will be provided for Nursing CEU credits. 1:00PM Closing Comments / Conference Adjourns Registration limited on a first come basis) Orlando E. Silva, MD, JD - USA REGISTRATION FORM To register, complete and mail this form to the Division of Continuing Medical Education, PO Box 016960 (D23-3), Miami, FL 33101-6960, or fax with credit card payment to (305)243-5613.

Name Company/Institution Address Postal Code City, State Country Phone Fax Email U.S. Registrant - Last 4 digist of Social Security Number (for recordkeeping purposes) Specialty

How did you hear of this program? Postcard Journal: ______Web Page Brochure Colleague Please specify if you will will not submit an abstract for this conference (Submission Deadline: June 20, 2003). Please indicate below the applicable registration fee and mark the additional sessions you wish to register for: Optional Sessions (in U.S. Dollars) Program Registration Surgical Hands-On Sessions † $350 Physicians in Practice (Registered prior to June 21, 2004) † $150 Sentinel Lymph Node Detection † $400 Physicians in Practice (Registered on/after June 21, 2004) † $150 Ductal Lavage † $200 Fellows, Residents, Nurses and Allied Health Professionals † $150 Ductal Endoscopy † $130 Accompanying Person - Friday Reception & Saturday Dinner Nursing Seminar † Patient Advocates / Cancer Survivors † $100

__ Check enclosed in the amount of US $______, payable to Division of Hematology/Oncology, UM

__ Charge my registration fee in the amount of $______to the following credit card: Visa Discover MasterCard

Card Number: Expiration Date: Name on Card: Authorized Signature:  HOTEL REGISTRATION FORM 2nd Interamerican Breast Cancer Conference July 21-24, 2004 To register, complete and mail this form to the Reservations Department, Ritz-Carlton Cancun, or fax with credit card payment to 011-52-(998)-881-0072.

Name Company/Institution Address Postal Code City, State Country Phone Fax Email Arrival Date: ______Departure Date: ______Room Rate: $155 plus 12% tax, Single or Double Occupancy, European Plan (excluding meals). Mail this form and guarantee reservation with one night’s deposit: __ Check enclosed in the amount of $______, payable to Ritz-Carlton, Cancun

__ Guarantee my first night’s deposit using the following credit card: __ Visa __MasterCard __American Express

Card Number: Expiration Date: Name on Card: Authorized Signature: GUEST FACULTY Course Director: Orlando E. Silva, M.D., J.D. Co-Directors: Shou-Ching Tang, M.D., Ph.D. Joyce Slingerland, M.D., Ph.D. Stefan Gluck, M.D., Ph.D.

Rodrigo Arriagada, M.D., Professor of Oncology, Instituto Edith Perez, M.D., Director, Clinical Investigation and Breast de Radiomedicina, Santiago, Chile Cancer Program, Division of Hematology/Oncology, Mayo Clinic; Chair, Breast Committee, NCCTG; Professor of Medicine, Mayo Lodovico Balducci, M.D., Professor of Oncology & Medicine, Medical School, Jacksonville, FL University of South Florida College of Medicine, Program Leader, Senior Adult Oncology Program, H. Lee Moffit Cancer Martine J. Piccart, M.D., Ph.D., Head of Chemotherapy Center & Research Institute, Tampa, Florida Department, Bordet Institute; Chairwoman, Breast International Group (BIG aisbl), Brussels, Belgium Jose Baselga, M.D., Chairman, Medical Oncology Service, Vall d’Hebron University Hospital; Professor of Medicine, Kathleen I. Pritchard, M.D., Head, Clinical Trials & Universidad Autonoma de Barcelona, Spain Epidemiology, Toronto Sunnybrook Regional Cancer Centre; Professor, Department of Medicine, Faculty of Medicine, University Phillip N. Blondeel, M.D., Ph.D. , Professor in Plastic of Toronto; Co-Chair, Breast Cancer Site Group; National Cancer Surgery , University Hospital Gent , Department of Plastic and Institute of Canada Clinical Trials Group; Clinical Director, Ontario Reconstructive Surgery , Gent, Belgium Clinical Oncology Group, Toronto, Canada

Jacques Bonneterre, M.D., Ph.D., M.B.A., Professor Sergio Rodriguez-Cuevas, M.D., Department of Surgical of Medicine, Centre Oscar Lambret, Lille, France Oncology, Hospital de Oncologia, Centro Medico Nacional IMSS, Mexico D.F., Mexico Sonia Maria Flores Moreno, M.D., Surgical Oncologist, Chief of Surgical Oncologic Service, Cancer Center of the Giovanni Rosti, M.D., Secretary of the Breast Cancer Registry Instituto Tecnologico y de Estudios Superiores de Monterrey of the EBMT (European Group for Blood and Marrow Transplant), (ITESM) School of Medicine & Hospital, San Jose Tec de Director of the High Dose Chemotherapy Unit, Oncology Monterrey, Monterrey, Nuevo Leon, Mexico Department, Ospedale Civile, Ravenna, Italy

Judy Garber, M.D., Associate Professor, Department of Eva Rubin, M.D.,Professor of Radiology, Mammography Medicine, Dana Farber Cancer Institute, Boston, MA Section, University of Alabama, Birmingham, AL

Juan Godinez, M.D., Radiation Oncologist; Fellow, Carolyn Sartor, M.D., Associate Professor of Radiation American Cancer Society; Vice-Director, Division of Radiation Oncology, Lineberger Cancer Center, University of North Carolina Oncology, Oncology & Radiation Associates, Miami, FL Medical School, Chapel Hill, NC

Gabriel N. Hortobagyi, M.D., Professor of Medicine and Carlos Sanchez-Basurto, M.D., Past President, Senologic Chairman, Department of Breast Medical Oncology, The International Society (SIS); Founder and Chairman, Breast Clinic: University of Texas, MD Anderson Cancer Center, Houston, TX Mastologica Lomas; Founder and First President, Mexican Association of Mastology; Past President, Mexican Society of John A. McLachlan, Ph.D., Weatherhead Distinguished Oncology; Past President, Mexican Academy of Surgery, Mexico Professor of Environmental Studies, Professor of Pharmacology, D.F., Mexico Director, Center for Bioenvironmental Research, Tulane and Xavier Universities; Acting Director, National Center for the Dennis J. Slamon, M.D., Ph.D., Professor of Medicine, Mississippi River, New Orleans, LA Chief, Division of Hematology/Oncology, Director of Clinical/ Translational Research, Jonsson Comprehensive Cancer Center; Ramin Mirhashemi, M.D., Associate Professor, Department David Geffen School of Medicine at UCLA, Los Angeles, CA of Obstetrics and Gynecology, UCLA School of Medicine, Los Angeles, CA Guido Tuveri, M.D., Director, Oncology Department, General Hospital, Trieste, Italy Hyman B. Muss, M.D., Professor of Medicine, University of Vermont; Director, Hematology/Oncology, Fletcher Allen Health Luz Venta, M.D., Professor of Radiology, Breast Care Center at Care, Burlington, VT Baylor College of Medicine and The Methodist Hospital, Houston, TX Jean-Marc A. Nabholtz, M.D., Professor of Medicine, American Hospital of Paris, Hartmann Oncology Institute, Paris, Umberto Veronesi, M.D., Scientific Director, European France Institute of Oncology, Milan, Italy

Andrew Pecora, M.D., Chairman and Director, The Cancer James Vredenburg, M.D., Associate Professor of Medicine Center At Hackensack University Medical Center, Clinical Division of Medical Oncology and Transplantation, Duke Professor of Medicine, University of Medicine and Dentistry of University, Durham, NC New Jersey, Hackensack, NJ Stefano Zurrida, M.D., Executive Advisor to Professor Veronesi, European Institute of Oncology, Milan, Italy University of Miami School of Medicine Division of Continuing Medical Education P.O. Box 016960 (D23-3) Miami, Fl 33101-6960

2nd Interamerican Breast Cancer Conference July 21-24, 2004 Ritz-Carlton, Cancun, Mexico

Sponsored by 2nd Interamerican Breast Cancer Conference

July 21-24, 2004 Ritz-Carlton Cancun, Mexico Painting by J. Villareal Sponsored by: The University of Miami School of Medicine Sylvester Comprehensive Cancer Center UNIVERSITY OF MIAMI SCHOOL OF MEDICINE FACULTY Eli Avisar, M.D., Assistant Professor of Surgery, Division of Surgical Joseph D. Rosenblatt, M.D., William J. Harrington, Professor Oncology; Co-Leader, Breast Site Disease Group, Sylvester of Medicine, Chief Hematology/Oncology Division; Scientific Comprehensive Cancer Center Director, UM Sylvester Comprehensive Cancer Center

Dido Franceschi, M.D., Associate Professor of Surgery, Carlos Sandoval, M.D., Assistant Professor, Department of Department of Surgery Psychiatry and Behavioral Medicine; Director, Courtelis Center for Psychosocial Oncology, UM Sylvester Comprehensive Cancer Stefan Glück, M.D., Ph.D. , Professor of Medicine; Associate Center Clinical Director, Breast Cancer Program, UM Sylvester Orlando E. Silva, M.D., J.D., F.A.C.P., Director of Breast Comprehensive Cancer Center and the Braman Institute Cancer Education, Assistant Professor of Clinical Medicine, UM

Sylvester Comprehensive Cancer Center Carmen Gomez-Fernandez, M.D., Assistant Professor of Pathology Joyce Slingerland M.D., Ph.D., F.R.C.P.(C), Director, Braman Breast Cancer Institute; Professor of Medicine, Division of Deborah Olin Heros, M.D., Assistant Professor, Department Hematology Oncology, UM Sylvester Comprehensive Cancer of Neurology; Director, Division of Neuro-Oncology, UM Sylvester Center Comprehensive Cancer Center Cristiane Takita, M.D., Assistant Professor, Radiation Oncology Judith Hurley, M.D., Associate Professor of Clinical Medicine Department, UM Sylvester Comprehensive Cancer Center/Jackson Memorial Hospital Merce Jorda M.D., Ph.D., Laboratory Director UMHC/ Sylvester Comprehensive Cancer Center, Associate Professor of Shou-Ching Tang, M.D., Ph.D., F.A.C.P., F.R.C.P.(C), Pathology Associate Director, Clinical Research,UM Sylvester Comprehensive Cancer Center; Director, Solid Tumor Oncology, Division of Frederick Moffat, M.D., Professor of Surgery Hematology/Oncology; Associate Professor of Medicine

Maria Victoria Velasquez, M.D., Assistant Professor of Clinical Luis E. Raez, M.D., F.A.C.P., Assistant Professor of Medicine Radiology; Chief of Breast Imaging, University of Miami, Jackson Epidemiology and Public Health, UM Sylvester Comprehensive Memorial Medical Center Cancer Center Pedro G. Velez, M.D., F.A.C.S., Medical Director, Taylor Stephen Richman, M.D., Professor of Medicine, UM Sylvester Breast Health Center, Jackson Memorial Hospital Comprehensive Cancer Center

ACCOMMODATIONS INSTITUTIONS AND

Ritz-Carlton Cancun FOUNDATIONS Retorno Del Rey No. 36 Zona Hotelera The University of Miami Sylvester Comprehensive Cancer Center Cancun, Q.ROO, Mexico 77500 gratefully acknowledges the following institutions and foundations Tel: 011-52-998-881-0808 ext. 5241 or 5230 for their support: Fax: 011-52-998-881-0072 http://www.ritz-carlton.com/resorts/cancun

Hotel Information Considered the premier Cancun hotel and one of the finest hotels in Mexico, this AAA Five-Diamond resort is situated on 1,200 feet of white-sand beaches in the heart of Mexico’s Yucatan playground. Here, you can explore an underwater world, marvel at the ancient treasures of the nearby Mayan ruins and choose from two award-winning restaurants.

Special Conference Rate A block of rooms have been reserved for conference participants at a special conference rate of US$155 plus 12% tax per room per night (European plan excluding meals) based on single or double occupancy. The special rate is guaranteed until June 20, 2004. Please add US$30.00 per day for each additional person over age 18 and/or over two (2) adults in a guestroom with a maximum of 3 adults or 2 adults and 2 children per guest room.