CLCN4 Polyclonal Antibody

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CLCN4 polyclonal antibody Catalog # : PAB22540 規格 : [ 100 uL ] List All Specification Application Image Product Rabbit polyclonal antibody raised against recombinant CLCN4. Immunohistochemistry (Formalin/PFA-fixed paraffin- Description: embedded sections) Immunogen: Recombinant protein corresponding to amino acids of human CLCN4. Sequence: VVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSP HPLKLRRILNLS Host: Rabbit enlarge Reactivity: Human Form: Liquid Purification: Antigen affinity purification Isotype: IgG Recommend Immunohistochemistry (1:20-1:50) Usage: The optimal working dilution should be determined by the end user. Storage Buffer: In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide) Storage Store at 4°C. For long term storage store at -20°C. Instruction: Aliquot to avoid repeated freezing and thawing. Note: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. Datasheet: Download Applications Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) Immunohistochemical staining of human pancreas with CLCN4 polyclonal antibody (Cat # PAB22540) shows strong cytoplasmic positivity in exocrine cells. Gene Information Page 1 of 2 2019/4/9 Entrez GeneID: 1183 Protein P51793 Accession#: Gene Name: CLCN4 Gene Alias: CLC4,ClC-4,ClC-4A,MGC163150 Gene chloride channel 4 Description: Omim ID: 302910 Gene Ontology: Hyperlink Gene Summary: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. [provided by RefSeq Other OTTHUMP00000022893 Designations: 服務條款 | 隱私權政策 | 著作及商標 | 網站地圖 ©2019 亞諾法生技股份有限公司 Abnova Corporation. 版權所有. Page 2 of 2 2019/4/9.

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An Advance About the Genetic Causes of Epilepsy
E3S Web of Conferences 271, 03068 (2021) https://doi.org/10.1051/e3sconf/202127103068 ICEPE 2021 An advance about the genetic causes of epilepsy Yu Sun1, a, *, †, Licheng Lu2, b, *, †, Lanxin Li3, c, *, †, Jingbo Wang4, d, *, † 1The School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801-3633, US 2High School Affiliated to Shanghai Jiao Tong University, Shanghai, 200441, China 3Applied Biology program, University of British Columbia, Vancouver, V6r3b1, Canada 4School of Chemical Machinery and Safety, Dalian University of Technology, Dalian, 116023, China †These authors contributed equally. Abstract: Human hereditary epilepsy has been found related to ion channel mutations in voltage-gated channels (Na+, K+, Ca2+, Cl-), ligand gated channels (GABA receptors), and G-protein coupled receptors, such as Mass1. In addition, some transmembrane proteins or receptor genes, including PRRT2 and nAChR, and glucose transporter genes, such as GLUT1 and SLC2A1, are also about the onset of epilepsy. The discovery of these genetic defects has contributed greatly to our understanding of the pathology of epilepsy. This review focuses on introducing and summarizing epilepsy-associated genes and related findings in recent decades, pointing out related mutant genes that need to be further studied in the future. 1 Introduction Epilepsy is a neurological disorder characterized by 2 Malfunction of Ion channel epileptic seizures caused by abnormal brain activity. 1 in Functional variation in voltage or ligand-gated ion 100 (50 million people) people are affected by symptoms channel mutations is a major cause of idiopathic epilepsy, of this disorder worldwide, with men, young children, and especially in rare genetic forms.
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