DOCSLIB.ORG

3.3 Effects of Oiigonucleotide Antisense to Dopamine Diareceptor Mrna on Sensitization of Apomorphine-Induced Rotations by Chronic

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
3.3 Effects of Oiigonucleotide Antisense to Dopamine Diareceptor Mrna on Sensitization of Apomorphine-Induced Rotations by Chronic National tibmy Bibliothèque nationale du Canada Acquisitions and Acquisitions et Bibliographie SeMces seMces biùliographiques 385 Welllngîon SB& 395, nie Weltington ûüawaON KIA ON4 ûttawaON KlAOiU4 Canada Cariada The author has granted a non- L'auteur a accordé melicence non exc1usi.e licence allowing the exclusive permettant à la National LÎbrary of Canada to Bibliothèque nationale du Canada de reproduce, loan, distrribute or sen reproduire, prêter, distribuer ou copies of this thesis in rnicroform, vendre des copies de cette thèse sous paper or electronic fornais. la forme de microfiche/fiIm, de reproduction sur papier ou sur format électronique. The anthor retains ownership of the L'auteur conserve la propriété du copyright in this thesis. Neither the droit d'auteur qui protège cette thése. thesis nor substafltid extracts f?om it Ni la thèse ni des extraits substantiels may be printed or otherwise de celle-ci ne doivent Etre imprimés reproduced without the author's ou autrement reproduits sans son permission. autorisation. The dopamine transporter @AT) hctions primady as a means for the termination of dopaminergic neurotransmission, but may aIso play a role in the pathogenesis of Parkkison's disease. Recent studies have implicated the DAT in the up take of two experimentai neurotoxins, 1-methyl4phenyI- 1,2,3,6-tetrahydrop yridine (MPTP) and 6-hydroxydopamine. Here, in Mvo administration of phosphorothioate adsense oügonucleotides targeting DAT mRNA in the left substantia nigra pars compacta resulted in reduced [3H]WIN 35,428 binding to DAT in the lefi striatum and signincant Ievodopa and amphetamine-induced conhalaterai rotations. Unilateral pretreatment with DAT antisense prior to bilaterd intrastriatal infiision of either neurotoxin resulted in asymrnetncd striatal DAT binding and dopamine content indicatuig significant preservation ipsilateral to antisense pretreatment. As well, significant apomorphine-induced ipsilaterai rotations were obsenred, suggesting neuroprotection of nigrostriatai neurons on the antisense-treated side. Thus, the DAT appears to play a critical role in determining susceptibility to these experimentd neurotoxins and rnay prove usefil as a marker for susceptibility to Parkinson's disease and as a target for therapeutic intervention. Regdation of dopamine neurotransmission by the DAT may aiso be an important factor in the development of dnig-induced dyskinesias. Dyskuiesias are abnomai involuntary movanents which deveIop as a side-effect of long-term treatment with either Ievodopa for Parkinson's (Ievodopa-induced dyskinesias) or antipsychotics (tardive dyskmesia) for schizophraiia The mechanhm tmderlyhg these dyskinesias remaÏns uncIear but may invoIve heightened activity in dopamine DIreceptor-bearing datonigral neurons. Here, intrastriataI infusion of antisense targeting dopamine DIAreceptor mRNA signifÏcantIy reduced striatai DIreceptor binding and attenuated behaviourd responses in rodent models of both levodopa-induced dyskinesia and tardive dyskinetia. Thus, the dopamine DIAreceptor rnay play a significant role in the expression of hg-induced dyskinesias. Recently, chronic pdsatiIe Ievodopa treatment in a rodent mode1 of levodopa- induced dyskinesias has been associated with increased expression of striatal dopamine D, receptors. These receptors are locaiized with DIreceptors on striatonigral neurons and their induction is dependent on dopamine DIreceptor activity. Here intmtriatal infusion of otigonucleotide antisense to dopamine D, receptor mRNA effectively reduced chronic Ievodopa-induced elevations in D, receptor expression and significantly reduced behaviourd responses in this modet. Thus, expression of levodopa-uiduced dyskinesias may aIso involve dopamine D3receptor activity, possibly through interaction with DI receptors. TABLE OF CONTENTS Page *. ABSTRACT fl TABLE OF CONTENTS iv LIST OF FIGTJRES X LIST OF TABLES xv 1.1 Basai Ganglia 1.1. I Introduction 1-1.2 Sm'atum 1. 1 -3 Globus Pallidus 1. f -4 Subthalamic Nucieus 1.1.5 Substantia Nigra 1.2 Basai Gangiia Disorders 1.2.1 Parkinson S Disese 12.2 Huntington 5 Diseare 12.3 Drug-lnduced Llyskinesras Page 1.3 Dopamine Receptors I t 1.3 .1 Dopamine Receptor CZassz~cation 11 1.3.2 Dopamine DI Receptors 12 1.3.3 Dopamine D3 Receptors 17 1.4 Dopamine Transporter 1.4.1 MolecuLar Structure 1.4.2 Lacaiization L .4.3 Functiun 1.5 Antisense Oligonucleotides i S. 1 Mechanism of Action 1 52Design 153 Therapeutic Potentiui 1.6 Rodent Models of Drug-Induced Dysbesias I -6.1 Levodopa-Induced Dysknesia 1-6.2 Tirdive Llyskinesia Page CHAPTER 2 EXPERIMENTAL DESIGN 37 2.1 Objectives 2.1.1 Rationale 2.1 -2Hypotheses 2.2 Gened Methods 2.2.1 Animafs 222surgq 2.2.3 Antisense OZigonucleotides 2.2.4 Chronic Drug Treatments 22.5 BehaviouraI Observations 2.2-6 A utoradiography 2.2.7 HPLC 2.2.8 Statistical AnaLys& CHAPTER 3 EXPERIMENTAL RESULTS 3.1 Effects of Ofigonucleotide Antisense to Dopamine D ,, Receptor mRNA on SKF 38393-Induced Behaviours 3 S.1 Introduction Page 3.1 2 Design 54 3 .1 -3 Results 54 3.1.4 Summary 63 3.2 Effects of Oligonucleotide Antisense to Dopamine DIAReceptor mRNA on Chronic Neuroleptic-Induced VCMs 3 2. 1 Introduction 3.2.2 Design 3 2.3 Redts 32.4 Summav 3.3 Effects of OLigonucleotide Antisense to Dopamine DIAReceptor mRNA on Sensitization of Apomorphine-Induced Rotations by Chroaic Levodopa in Hemiparkinsonian Rats 3.3.1 Introduction 3.3 -2 Design 3-3 -3 ResrrIts 3.3.4 Smmm 3.4 Effects of OligonucIeotide Antisense to Dopamine DjReceptor mRNA on Sensïtization of Apomorphine-hduced Rotations by Chronic Levodopa m HemiparkÏnsonÏan Rats Page 3 .4.l Introduction 84 3.4.2 Design 85 3*4,3 Results 86 3 -4.4 Sumrnary 89 3.5 Effects of Oligonucleotide Antisense to Dopamine Transporter mRNA on Locomotor Responses to Levodopa and Amphetamine 3 S. I htmduction 3.5.2 Design 3 53Resuits 3 S.4 Summav 3.6 Effects of Oügonucleotide Antiseose to Dopamine Transporter mRNA on the Neurotoxicity of MPP' and 6-OHDA 3,6.1 Introduction 3 -6.2 Design 3.6.3 Results 3.6.4 Summmy CHAPTE.4 GENERAL DISCUSSION Page 4.1 Discussion 112 4.2 ConcIusions l29 LIST OF FIGURES Fig. Descriptioa Page Basai gangIia circuitry in primates. 5 Antisense mechanism of action. 28 Stnatai dopamine transporter binding following unilateral infiision of 6-OHDA under ketamine versus halothane anaesthesia. Effects of in-atal infusion ofoligonuc teotide antisense to dopamine DIAreceptor mRNA on SKF 38393-hduced mouth movements. 56 Effects of Uitmstriatal infusion of oligonucleotide antisense to dopamine DIAreceptor mRNA on SKF 38393-hduced groomuig. 57 Dopamine DI receptor binding in the striatum folIowing intmtriatal Uifusion of oIigonuc1eotide antisense to dopamine D receptor &A. Autoradiograph representing [%j SCH 23390 binding in the striatinn foiIowing bilateral Uitrastriatai infusion of oligonucleotide antisense to dopamine DIAreceptor mRNA. Dopamine D2receptor bbding in the striahm following intrastriatai uifusion of oligonucIeotide antiseme to dopa-mhe: DIAreceptor mRNk Antoradiograph representing [%Ilracfopride bindhg in the sûiahun Page following intrastriatal infusion of oligonucIeotide antisense to dopamine DIAreceptor rnRNA. 62 10. Chronic fiuphenazine-induced mouth movements following intrastriatd infusion of oiigonucleotide antisense to dopamine DIAreceptor mRNA. 1 1. Dopamine D , receptor binding foUowing htrastriatal infusion of oiigonucleotide antisense to dopamine DIAreceptor mRNA in rats treated chronically with fluphenazine. 12. Dopamine D2receptor binding following intrastriatd infiision of oiigonucleotide antisense to dopamine DIAreceptor mRNA in rats treated chronicaIIy with fluphenazine. 13. Dopamine D3receptor binding followhg intrastn*atai&sion of oiigonucIeotide antisense to dopamine DIAreceptor mRNA in rats treated chronicdIy with Buphenazine. 14. Effects of intrastriatd Uifiision of oiigonucleotide antisense to dopamine DIAreceptor mRNA on apomorphine-induced rotations in a rodent mode1 of LID. 15. StnataI dopamine Direceptor buiding followhg unilatmai intrastriatal infuson of oligonucleotide antisense to dopamine DIAreceptor mRNA in a rodent mode1 of LID, 16. Autoradiograph representhg [%Q Sa23390 binding in the siriahmi foiiowing unilaterd htrastn'*atai mfiision oligonucIeotide Page antisense to dopamine DIAreceptor mRNA in hemiparkuisonian rats. 78 17. Striatal dopamine D2receptor binding foiIowing daterai intraStnatal Uifusion of oligonucleotide antisense to dopamine DI, receptor mRNA in a rodent model of Lm. 18- Autoradiograph representing ['Hl radopride binding in the striatum following unilateral intrastriatal infusion of 01igonucIeotide antisense to dopamine DIAreceptor -A. 19. Striatai dopamine D, receptor binding following intrastriatai infusion of oligonucleotide antisense to dopamine D ,, receptor mRNA in a rodent model of LID, 20. E ffects of inWataI uifusion of o ligonucleotide antisense to dopamine D, receptor mRNA on apomorphine-induced rotations in a rodent model of LID. 2 I . Shiatai dopamine D3 receptor binding foilowing intrastriatal uifusion of oligonucIeotide antisense to dopamine D3 receptor mRNA in a rodent model of Lm. 22. Striatai dopamine DIreceptor binding folIowing unilateral intrastriatai mtllsion of oligonucleotide antisense to dopamine D3receptor mRNA in a rodent model of LID. 23. Striatai dopamine 4 receptor binding folIowing intrastriatai Wonof oligonucleotide antiseme to dopamine D3receptor mRNA in a rodent mode1 of LID. 24. Striatal dopamine transporter binding folloaring unilaterai infusion of oligonucleotide antisense
Load more

Recommended publications
  • William T. Rowe
    Bao Shichen: An Early Nineteenth-Century Chinese Agrarian Reformer William T. Rowe Johns Hopkins University Prefatory note to the Agrarian Studies Program: I was greatly flattered to receive an invitation from Jim Scott to present to this exalted group, and could not refuse. I’m also a bit embarrassed, however, because I’m not working on anything these days that falls significantly within your arena of interest. I am studying in general a reformist scholar of the early nineteenth century, named Bao Shichen. The contexts in which I have tended to view him (and around which I organized panels for the Association for Asian Studies Annual Meetings in 2007 and 2009) have been (1) the broader reformist currents of his era, spawned by a deepening sense of dynastic crisis after ca. 1800, and (2) an enduring Qing political “counter discourse” beginning in the mid-seventeenth century and continuing down to, and likely through, the Republican Revolution of 1911. Neither of these rubrics are directly concerned with “agrarian studies.” Bao did, however, have quite a bit to say in passing about agriculture, village life, and especially local rural governance. In this paper I have tried to draw together some of this material, but I fear it is as yet none too neat. In my defense, I would add that previously in my career I have done a fair amount of work on what legitimately is agrarian history, and indeed have taught courses on that subject (students are less interested in such offerings now than they used to be, in my observation).
    [Show full text]
  • Economic Geography Study on the Formation of Taobao Village: Taking
    Economic Geography Vol. 35, No. 12, 90–97 Dec. 2015 Study on the formation of Taobao Village: taking Dongfeng Village and Junpu Village as examples ZENG Yiwu1, QIU Dongmao1, SHEN Yiting2, GUO Hongdong1 1. The Center for Agriculture and Rural Development, Zhejiang University, Hangzhou 310058, Zhejiang, China; 2. Information Center, Zhejiang Radio & Television University, Hangzhou 310030, Zhejiang, China Abstract: Based on typical cases of Dongfeng Village and Junpu Village, this paper analyzed the formation of Taobao Village. It is found that the formation of Taobao Village includes five processes: introduction of Taobao projects, primary diffusion, accelerated diffusion, collective cooperation and vertical agglomeration. They can be reduced into two stages. In the first stage, the germination and initial development of Taobao Village only rely on the folk spontaneous forces; secondly, the government begins to intervene, the e-commerce association is set up, and all kinds of service providers are stationed in the village. To speed up the formation of those embryonic Taobao Villages, the government’s support is necessary, and the key point is intensifying scientific guidance and service ability, and improving supply level of public goods timely. To cultivate more new Taobao Villages, some incubation measures can be taken, such as reinforcing infrastructure construction, enhancing the cost advantage of rural entrepreneurship, excavating the potential of local traditional industries, and encouraging some migrant workers of the new generation and university graduates to return. Keywords: E-commerce, farmer entrepreneurship, Taobao Village, Internet plus CLC number: F320, F724.6 As the typical product of “Internet + rural economy,” and Donggao Village of Qinghe County of Hebei Province.
    [Show full text]
  • Archaeological Observation on the Exploration of Chu Capitals
    Archaeological Observation on the Exploration of Chu Capitals Wang Hongxing Key words: Chu Capitals Danyang Ying Chenying Shouying According to accurate historical documents, the capi- In view of the recent research on the civilization pro- tals of Chu State include Danyang 丹阳 of the early stage, cess of the middle reach of Yangtze River, we may infer Ying 郢 of the middle stage and Chenying 陈郢 and that Danyang ought to be a central settlement among a Shouying 寿郢 of the late stage. Archaeologically group of settlements not far away from Jingshan 荆山 speaking, Chenying and Shouying are traceable while with rice as the main crop. No matter whether there are the locations of Danyang and Yingdu 郢都 are still any remains of fosses around the central settlement, its oblivious and scholars differ on this issue. Since Chu area must be larger than ordinary sites and be of higher capitals are the political, economical and cultural cen- scale and have public amenities such as large buildings ters of Chu State, the research on Chu capitals directly or altars. The site ought to have definite functional sec- affects further study of Chu culture. tions and the cemetery ought to be divided into that of Based on previous research, I intend to summarize the aristocracy and the plebeians. The relevant docu- the exploration of Danyang, Yingdu and Shouying in ments and the unearthed inscriptions on tortoise shells recent years, review the insufficiency of the former re- from Zhouyuan 周原 saying “the viscount of Chu search and current methods and advance some personal (actually the ruler of Chu) came to inform” indicate that opinion on the locations of Chu capitals and later explo- Zhou had frequent contact and exchange with Chu.
    [Show full text]
  • The History of Holt Cheng Starts 88Th
    The Very Beginning (written with great honor by cousin Basilio Chen 鄭/郑华树) The Roots Chang Kee traces his family roots as the 87th descendant of Duke Huan of Zheng (鄭桓公), thus posthumorously, Dr. Holt Cheng is referred to in the ancient family genealogical tradition Duke Holt Cheng, descendant of the royal family Zhou (周) from the Western Zhou Dynasty. The roots and family history of Chang Kee starts over 2,800 years ago in the Zhou Dynasty (周朝) when King Xuan (周宣王, 841 BC - 781 BC), the eleventh King of the Zhou Dynasty, made his younger brother Ji You (姬友, 806 BC-771 BC) the Duke of Zheng, establishing what would be the last bastion of Western Zhou (西周朝) and at the same time establishing the first person to adopt the surname Zheng (also Romanized as Cheng in Wades-Giles Dictionary of Pronunciation). The surname Zheng (鄭) which means "serious" or " solemn", is also unique in that is the only few surname that also has a City-State name associated it, Zhengzhou city (鄭國 or鄭州in modern times). Thus, the State of Zheng (鄭國) was officially established by the first Zheng (鄭,) Duke Huan of Zheng (鄭桓公), in 806 BC as a city-state in the middle of ancient China, modern Henan Province. Its ruling house had the surname Ji (姬), making them a branch of the Zhou royal house, and were given the rank of bo (伯,爵), corresponding roughly to an earl. Later, this branch adopted officially the surname Zheng (鄭) and thus Ji You (or Earl Ji You, as it would refer to in royal title) was known posthumously as Duke Huan of Zheng (鄭桓公) becoming the first person to adopt the family surname of Zheng (鄭), Chang Kee’s family name in Chinese.
    [Show full text]
  • Chronology of Chinese History
    Chronology of Chinese History I. Prehistory Neolithic Period ca. 8000-2000 BCE Xia (Hsia)? Trad. 2200-1766 BCE II. The Classical Age (Ancient China) Shang Dynasty ca. 1600-1045 BCE (Trad. 1766-1122 BCE) Zhou (Chou) Dynasty ca. 1045-256 BCE (Trad. 1122-256 BCE) Western Zhou (Chou) ca. 1045-771 BCE Eastern Zhou (Chou) 770-256 BCE Spring and Autumn Period 722-468 BCE (770-404 BCE) Warring States Period 403-221 BCE III. The Imperial Era (Imperial China) Qin (Ch’in) Dynasty 221-207 BCE Han Dynasty 202 BCE-220 CE Western (or Former) Han Dynasty 202 BCE-9 CE Xin (Hsin) Dynasty 9-23 Eastern (or Later) Han Dynasty 25-220 1st Period of Division 220-589 The Three Kingdoms 220-265 Shu 221-263 Wei 220-265 Wu 222-280 Jin (Chin) Dynasty 265-420 Western Jin (Chin) 265-317 Eastern Jin (Chin) 317-420 Southern Dynasties 420-589 Former (or Liu) Song (Sung) 420-479 Southern Qi (Ch’i) 479-502 Southern Liang 502-557 Southern Chen (Ch’en) 557-589 Northern Dynasties 317-589 Sixteen Kingdoms 317-386 NW Dynasties Former Liang 314-376, Chinese/Gansu Later Liang 386-403, Di/Gansu S. Liang 397-414, Xianbei/Gansu W. Liang 400-422, Chinese/Gansu N. Liang 398-439, Xiongnu?/Gansu North Central Dynasties Chang Han 304-347, Di/Hebei Former Zhao (Chao) 304-329, Xiongnu/Shanxi Later Zhao (Chao) 319-351, Jie/Hebei W. Qin (Ch’in) 365-431, Xianbei/Gansu & Shaanxi Former Qin (Ch’in) 349-394, Di/Shaanxi Later Qin (Ch’in) 384-417, Qiang/Shaanxi Xia (Hsia) 407-431, Xiongnu/Shaanxi Northeast Dynasties Former Yan (Yen) 333-370, Xianbei/Hebei Later Yan (Yen) 384-409, Xianbei/Hebei S.
    [Show full text]
  • Table of Contents (PDF)
    Cancer Prevention Research Table of Contents June 2017 * Volume 10 * Number 6 RESEARCH ARTICLES 355 Combined Genetic Biomarkers and Betel Quid Chewing for Identifying High-Risk Group for 319 Statin Use, Serum Lipids, and Prostate Oral Cancer Occurrence Inflammation in Men with a Negative Prostate Chia-Min Chung, Chien-Hung Lee, Mu-Kuan Chen, Biopsy: Results from the REDUCE Trial Ka-Wo Lee, Cheng-Che E. Lan, Aij-Lie Kwan, Emma H. Allott, Lauren E. Howard, Adriana C. Vidal, Ming-Hsui Tsai, and Ying-Chin Ko Daniel M. Moreira, Ramiro Castro-Santamaria, Gerald L. Andriole, and Stephen J. Freedland 363 A Presurgical Study of Lecithin Formulation of Green Tea Extract in Women with Early 327 Sleep Duration across the Adult Lifecourse and Breast Cancer Risk of Lung Cancer Mortality: A Cohort Study in Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Xuanwei, China Sara Gandini, Harriet Johansson, Davide Serrano, Jason Y. Wong, Bryan A. Bassig, Roel Vermeulen, Wei Hu, Massimiliano Cazzaniga, Valentina Aristarco, Bofu Ning, Wei Jie Seow, Bu-Tian Ji, Debora Macis, Serena Mora, Pietro Caldarella, George S. Downward, Hormuzd A. Katki, Gianmatteo Pagani, Giancarlo Pruneri, Antonella Riva, Francesco Barone-Adesi, Nathaniel Rothman, Giovanna Petrangolini, Paolo Morazzoni, Robert S. Chapman, and Qing Lan Andrea DeCensi, and Bernardo Bonanni 337 Bitter Melon Enhances Natural Killer–Mediated Toxicity against Head and Neck Cancer Cells Sourav Bhattacharya, Naoshad Muhammad, CORRECTION Robert Steele, Jacki Kornbluth, and Ratna B. Ray 371 Correction: New Perspectives of Curcumin 345 Bioactivity of Oral Linaclotide in Human in Cancer Prevention Colorectum for Cancer Chemoprevention David S. Weinberg, Jieru E. Lin, Nathan R.
    [Show full text]
  • Sense of Economic Gain from E-Commerce: Different Effects on Poor and Non-Poor Rural Households
    106 Sense of Economic Gain from E-Commerce: Different Effects on Poor and Non-Poor Rural households * Wang Yu (王瑜) Rural Development Institute, Chinese Academy of Social Sciences (CASS), Beijing, China Abstract: Sense of economic gain of e-commerce participation is an important aspect for evaluating the inclusiveness of e-commerce development. Based on the data of 6,242 rural households collected from the 2017 summer surveys conducted by the China Institute for Rural Studies (CIRS), Tsinghua University, this paper evaluates the effects of e-commerce participation on rural households’ sense of economic gain with the propensity score matching (PSM) method, and carries out grouped comparisons between poor and non- poor households. Specifically, the “Self-evaluated income level relative to fellow villagers” measures respondents’ sense of economic gain in the relative sense, and “Percentage of expected household income growth (reduction) in 2018 over 2017” measures future income growth expectation. Findings suggest that e-commerce participation significantly increased sample households’ sense of economic gain relative to their fellow villagers and their future income growth expectation. Yet grouped comparisons offer different conclusions: E-commerce participation increased poor households’ sense of economic gain compared with fellow villagers more than it did for non-poor households. E-commerce participation did little to increase poor households’ future income growth expectation. Like many other poverty reduction programs, pro-poor e-commerce helps poor households with policy preferences but have yet to help them foster skills to prosper in the long run. The sustainability and quality of perceived relative economic gain for poor households are yet to be further observed and examined.
    [Show full text]
  • Yue Liang Department of Human Development and Family Studies the University of North Carolina at Greensboro Greensboro, NC, 27403 (336) 500-9596 Y [email protected]
    Yue Liang Department of Human Development and Family Studies The University of North Carolina at Greensboro Greensboro, NC, 27403 (336) 500-9596 [email protected] EDUCATION 2012-2014 Beijing Normal University, Beijing, China School of Psychology M.S. Developmental Psychology, June 2014 Major Field: Developmental Psychology Minor Fields: Cognitive Neuroscience Thesis: Dual processing in creative thinking: The role of working memory 2008-2012 China University of Political Science and Law, Beijing, China Department of Psychology B.S. June 2012 Thesis: Research on relationship between family cohesion and implicit aggression of adolescents with externalizing behaviors AREAS OF SCIENTIFIC INTEREST Social development of child and adolescent, moral development, parenting behaviors PUBLICATIONS Cao, H., Zhou, N., Mills-Koonce, W. R., Liang, Y., Li, J., & Fine, A. M. (Under review). Minority Stress and Relationship Outcomes among Same-sex Couples: A Meta-Analysis. Journal of Family Theory and Review. Kiang, L., Mendonça, S. E, Liang, Y., Payir, A., , Freitas, L. B. L., O’Brien, L., & Tudge, J. R. H. (Under review). If Children Won Lotteries: Materialism, Gratitude, and Spending in an Imaginary Windfall. Social Development. Tudge, J. R. H., Payir, A., Merçon-Vargas, E., Cao, H., Liang, Y., & Li, J. (Under review). Still misused after all these years? A re-evaluation of the uses of Bronfenbrenner’s bioecological theory of human development. Journal of Family Theory and Review. MANUSCRIPTS IN PROGRESS Liang, Y., Zhou, N. & Cao, H. (In progress). Maternal provision of learning opportunities in early childhood and externalizing behaviors in early adolescence: The mediation role of executive functioning. Mokrova, I., Liang, Y., & Tudge, J.
    [Show full text]
  • Official Colours of Chinese Regimes: a Panchronic Philological Study with Historical Accounts of China
    TRAMES, 2012, 16(66/61), 3, 237–285 OFFICIAL COLOURS OF CHINESE REGIMES: A PANCHRONIC PHILOLOGICAL STUDY WITH HISTORICAL ACCOUNTS OF CHINA Jingyi Gao Institute of the Estonian Language, University of Tartu, and Tallinn University Abstract. The paper reports a panchronic philological study on the official colours of Chinese regimes. The historical accounts of the Chinese regimes are introduced. The official colours are summarised with philological references of archaic texts. Remarkably, it has been suggested that the official colours of the most ancient regimes should be the three primitive colours: (1) white-yellow, (2) black-grue yellow, and (3) red-yellow, instead of the simple colours. There were inconsistent historical records on the official colours of the most ancient regimes because the composite colour categories had been split. It has solved the historical problem with the linguistic theory of composite colour categories. Besides, it is concluded how the official colours were determined: At first, the official colour might be naturally determined according to the substance of the ruling population. There might be three groups of people in the Far East. (1) The developed hunter gatherers with livestock preferred the white-yellow colour of milk. (2) The farmers preferred the red-yellow colour of sun and fire. (3) The herders preferred the black-grue-yellow colour of water bodies. Later, after the Han-Chinese consolidation, the official colour could be politically determined according to the main property of the five elements in Sino-metaphysics. The red colour has been predominate in China for many reasons. Keywords: colour symbolism, official colours, national colours, five elements, philology, Chinese history, Chinese language, etymology, basic colour terms DOI: 10.3176/tr.2012.3.03 1.
    [Show full text]
  • The Davie Record DAVIB COUNTY’S ODDEST NBWSPAPER-THE PAPER the BEOPDE READ
    The Davie Record DAVIB COUNTY’S ODDEST NBWSPAPER-THE PAPER THE BEOPDE READ NEWS OF LONG AGO. AT PEACE WITH GOO Connty Has Hnge Joh CooIeemee Christmas Is The War Over? Seen AlongMain Street Rev. Walter E. henhonr. Hiddenite.!). C. More than $370,000 is expected Party Great Success Fighting for au ally of - Aineri ByTheStteetRanibler. Wbat Was Happemag In Davie The heart: and soul at peace with to be spent during the next five ca dvrihg the~w<ir is one thing and oooooo BK HARRY S. STROUD. - Before Tbe New Deal UsedVp God years by Davie County home own­ fighting tor one half j of China a Miss Ruth Lakey ‘wearing new The Christmas party for the Has’pleasures sweet aloug life’s ers on remodeliug and repair work. gainst the other half in a civil war pair of rubber boots—Cjarence Tbe Alphabet, Drowned The children of Erwin mill workers at way, The year 1946 promises to inau­ is another: Craven looking happy after foe - Hapaaad Plowed Up .The Cooleemee which, was igld at the Although sometimes ,affliction’s gurate one of the greatest areas in ...That’s what’, American.... aiimen holidays—Herbert Haire shaking Cottoa and Cora. rod . American history, for., home iool building Saturday tbmk.. reported angrily protistlng Handgwkh ^ iends-M fcs Hazel pairs and modernization, accord­ evening, Dee. 22, was a great sue- (Davie Record, Jan. 5. 1910) May seem quite heavy for die their postwar assignment to fly Mcdamroch driving slowly acrois ing to estimates 'released by the cess. The party was sponsored by Cotton ls 13 cents.
    [Show full text]
  • In China: Why Young Rural Women Climb the Ladder by Moving Into China’S Cities
    “Making It” In China: Why Young Rural Women Climb the Ladder by Moving into China’s Cities By Lai Sze Tso A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Women’s Studies and Sociology) in the University of Michigan 2013 Doctoral Committee: Professor Mary E. Corcoran, Co-Chair Professor Fatima Muge Gocek, Co-Chair Professor Pamela J. Smock Associate Professor Zheng Wang © Lai Sze Tso 2013 DEDICATION I dedicate this dissertation to Mom, Danny, Jeannie, and Dad. I could not have accomplished this without your unwavering love and support. During the toughest times, I drew strength from your understanding and resilience. ii ACKNOWLEDGEMENTS I would like to recognize the invaluable guidance of my dissertation committee, Pam Smock, Muge Gocek, Wang Zheng, and Mary Corcoran. I also learned a great deal about China as a member of James Lee's research team. Thank you James and Cameron Campbell for teaching me the ropes in Chinese academe, and Zhang hao for helping me adjust to fieldwork in North River. I am also indebted to Xiao Xing for digitizing complex hukou files, and Wang Laoshi and Yan Xianghua for helping me navigate the administrative culture at Peking University, Weiran Chen, her family, and Gao Zuren will always have a special place in my heart for the help and hospitality shown me while during the first phase of my research endeavors. Preliminary field work in North River and early drafts of dissertation chapters benefitted immensely from keen insight provided by fellow research team members Danching Ruan, Wang Linlan, Li Lan, Shuang Chen, Li Ji, Liang Chen, Byung-Ho Lee and Ka Yi Fung.
    [Show full text]
  • Analysis of Vaccine Structure, Storage, Moisture, and Classification by Infrared Technology
    Downloaded from orbit.dtu.dk on: Oct 02, 2021 Analysis of vaccine Structure, storage, moisture, and classification by infrared technology Zheng, Yiwu Publication date: 2006 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): Zheng, Y. (2006). Analysis of vaccine: Structure, storage, moisture, and classification by infrared technology. Technical University of Denmark. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Analysis of vaccine: Structure, storage, moisture, and classification by infrared technology Ph.D. Thesis by Yiwu Zheng 2006 BioCentrum-DTU Section of Biochemistry and Nutrition Technical University of Denmark Building 224, Sølvtofts Plads 2800 Kgs. Lyngby Denmark Preface This thesis has been submitted as partial fulfilment of the requirement for a Ph.D. degree at the Technical University of Denmark. The work has been done at Biochemistry and Nutrition Group, BioCentrum-DTU and ALK-Abelló A/S.
    [Show full text]