Thomas E. Starzl
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Immunosuppressive Effects in Infection
I Volume 63 January 1970 I1I J- 6 JAN'7O Section of Clinical ~~~~~~~~~ Immunology & Allergy President Professor Sir Michael Woodruff FRCS FRS Meeting April 14 1969 Immunosuppressive Effects in Infection Dr M H Salaman Measles: In 1908 von Pirquet noticed that the (Department ofPathology, Royal College tuberculin reaction in tuberculous children be- ofSurgeons oJ England, came negative during an attack of measles, and London) that afterwards tuberculosis often advanced rapidly. Later work has confirmed his observa- Immunodepression by tions on tuberculin sensitivity by more sensitive Mammalian Viruses and Plasmodia methods (Mellman & Wetton 1963, Brody & McAlister 1964, Starr & Berkovitch 1964), and it Depression of immune responses by viruses is has been shown (Smithwick & Berkovitch 1966) receiving increasing though much belated atten- that measles virus, added to lymphocytes of tion. Early reports (von Pirquet 1908, Bloomfield tuberculin-positive patients, prevents the mito- & Mateer 1919) were forgotten and the subject genic response to tuberculin PPD, but not the neglected till 1960 when Old and his colleagues response to phytohmmagglutinin (PHA). noticed that the hmemolysin response to sheep erythrocytes (SE) was depressed in mice infected Rubella: In infants with congenital rubella there with Friend's leukeemogenic virus (FV), and is no gross defect of antibody formation, but their Gledhill (1961) found that FV and Moloney virus lymphocytes do not respond to PHA (Alford both enhanced the pathogenicity of mouse 1965, Bellanti et al. 1965, Soothill et al. 1966). hepatitis virus. Since then reports of immuno- Normal lymphocytes treated with rubella virus in depression by a wide variety of viruses, both vitro lose their PHA-responsiveness. -
Research Progress Report
ARMY M E DI CA L s E RVICE- ARM1.950117.018 RESEARCH PROGRESS REPORT THE INFORMATION CGNTAINED HEREIN IS UWCLASSlFlED BUT HAY NOT BE PUBLISKED WITHOUT THE EXPRESS PERMISSION OF THE CHAl RHAN. HEDlCbL RESEARCH AND DEVELOPMENT BOARD, OFFICE OF THE SURGEON GENERAL. @VkRTMENT OF THE AMY. ANNUAL REPORT I JULY 1952 -30 JUNE 1953 MEDICAL RESEARCH AND DEVELOPMENT BOARD OFFICE OF THE SURGEON GENERAL U. S. ARMY Inveatigatar Project or Project &!e Title -Number Locatloo PJ. ybical Hfects of the ktanic Rcab..... .. .. ..&55)-'.)&(j3 BJUatlm ssd !Chcmd. Burna. e.. .. , . .6-53-0ti-o& RdiatiOn Them BW SwCand Medical kBptct6 Of IaliZing Radiation.. +. .6-59-0&-14 zftects of Irradiaticm mecto of lmizing Rdiatim Sfect of Irradlatim m SIngk-Cell Orgauisnre 1miurtiOn Effects Biologic and Medical mtsof ICaizlng Radiation ~ets-OBlmaDoee Ratio FP Surfaces Ccmtsminated with Piisicu Products matneut of Irrdiatiaa Sickness vith Spleen Emzgenate ard BQlc MrrOy Relative Biologic Effectiveness of 4 Mev G- Rays Imizatlon Effects . Wet of Rediatlaa m Irm Metabolism and Eca¶topoieEiE pathoiogic study of Central Barvous System Effecti of Ionizhg Rsdiatim m WythroCytes -si# uf Irdirect Bfiect of RwIiattFm BunrS.. ,, * . .. * * * m. .. .. .. .. , . .6-59-12-21 'Ibcrad Burns Cllaic~LStudies in lbarsL Injuries Ccllplications Butn Death6 Air EvsCUatiOIl Wiscellaneoua Clinid Studies wttabolic Chengea af3.er Inftpr DeterminatiOll of aLood Valtoe, Extracellulm Fluid Spece, and Hem Water Equilibration Times 5n Dcga Acutely Depleted cd 5 to 1%of Total gxcbange&le Ex4y Potasaim -
The History of the First Kidney Transplantation
165+3 14 mm "Service to society is the rent we pay for living on this planet" The History of the Joseph E. Murray, 1990 Nobel-laureate who performed the first long-term functioning kidney transplantation in the world First Kidney "The pioneers sacrificed their scientific life to convince the medical society that this will become sooner or later a successful procedure… – …it is a feeling – now I am Transplantation going to overdo - like taking part in creation...” András Németh, who performed the first – a European Overview Hungarian renal transplantation in 1962 E d i t e d b y : "Professor Langer contributes an outstanding “service” to the field by a detailed Robert Langer recording of the history of kidney transplantation as developed throughout Europe. The authoritative information is assembled country by country by a generation of transplant professionals who knew the work of their pioneer predecessors. The accounting as compiled by Professor Langer becomes an essential and exceptional reference document that conveys the “service to society” that kidney transplantation has provided for all mankind and that Dr. Murray urged be done.” Francis L. Delmonico, M.D. Professor of Surgery, Harvard Medical School, Massachusetts General Hospital Past President The Transplantation Society and the Organ Procurement Transplant Network (UNOS) Chair, WHO Task Force Organ and Tissue Donation and Transplantation The History of the First Kidney Transplantation – a European Overview European a – Transplantation Kidney First the of History The ISBN 978-963-331-476-0 Robert Langer 9 789633 314760 The History of the First Kidney Transplantation – a European Overview Edited by: Robert Langer SemmelweisPublishers www.semmelweiskiado.hu Budapest, 2019 © Semmelweis Press and Multimedia Studio Budapest, 2019 eISBN 978-963-331-473-9 All rights reserved. -
160528 Dr. Edgar Franke
Prof. Dr. J. Floege • Rheinisch-Westfälische Technische Hochschule Aachen Universitätsklinikum • Medizinische Klinik II • Pauwelsstr. 30 • 52074 Aachen Geschäftsstelle Seumestr. 8 10245 Berlin Dr. Edgar Franke Ausschuss für Gesundheit Telefon: 030 52137269 Deutscher Bundestag Telefax: 030 52137270 Platz der Republik 1 E-Mail: [email protected] 11011 Berlin www.dgfn.eu Berlin, 29.5.2016 Vorstand: Prof. Dr. J. Floege (Präsident) Rheinisch-Westfälische Sehr geehrter Herr Dr. Franke, Technische Hochschule Aachen Universitätsklinikum Medizinische Klinik II, die Dt. Gesellschaft für Nephrologie bedankt sich für die Gelegenheit Nephrologie und Klinische einer Stellungnahme zum geplanten Transplantationsregister. Immunologie Pauwelsstr. 30 Wir begrüßen die Initiative eines bundesweiten Transplantationsregisters 52074 Aachen ausdrücklich, möchten aber unter Bezugnahme auf das mit Frau Prof. Dr. Elke Telefon: 0241 8089530 Schäffner am 15.4.16 geführte Obleutegespräch an dieser Stelle erneut auf Telefax: 0241 8082446 E-Mail: [email protected] einen Umstand hinweisen, der unserer Ansicht nach in dem bisherigen Gesetzesentwurf zu kurz greift, die Verknüpfung eines Prof. Dr. K. Amann Transplantationsregisters mit einem Dialyseregister. Prof. Dr. M. D. Alscher Prof. Dr. A. Kribben Aus folgenden Gründen halten wir eine solche Datenverknüpfung für Dr. T. Weinreich unerlässlich: Kuratorium: • Die Nephrologie ist in der Transplantationslandschaft einzigartig, da es Prof. Dr. A. Kribben flächendeckend und jahre/jahrzehntelang Nierenersatzverfahren gibt, die (Vorsitzender) -
Historic Landmarks in Clinical Transplantation: Conclusions from the Consensus Conference at the University of California, Los Angeles
World J. Surg.24, 834-843, 2000 DOl: 10.1007/5002680010134 WORLD Journal of SURGERY © .lOOO by rhe Societe Internationale J(" Ch!wrgie Historic Landmarks in Clinical Transplantation: Conclusions from the Consensus Conference at the University of California, Los Angeles Carl G. Groth, M.D., Ph.D.,l Leslie B. Brent, B.Sc., Ph.D} Roy Y. Caine, M.D} Jean B. Dausset, M.D., Ph.D.,4 Robert A. Good, M.D., Ph.D.,s Joseph E. Murray, M.D.,6 Norman E. Shumway, M.D., Ph.D} Robert S. Schwartz, M.D} Thomas E. Starzl, M.D., Ph.D} Paul I. Terasaki, Ph.D.,l° E. Donnall Thomas, M.D}l Jon J. van Rood, M.D., Ph.DY 1Department of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, SE-141 86 Huddinge, Sweden 230 Hugo Road, Tufnell Park, London N19 5EU, UK 'Department of Surgery, University of Cambridge, Douglas House Annexe, 18 Trumpington Road, Cambridge CB2 ZAH, UK "Foundation Jean Dausset-C.E.P.H., 27 rue Juliette Dodu, 75010 Paris Cedex, France 5Department of Pediatrics, Division of Allergy and Immunology, All Children's Hospital, 801 Sixth Street South, SI. Petersburg, Florida 33701, USA "Department of Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA 'Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5247, USA 'The New England Journal of Medicine, 10 Shattuck Street, Boston, Massachusetts 02115-6094, USA 9Department of Surgery, University of Pittsburgh, School of Medicine, Thomas E. Starzl Transplantation Institute, 3601 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA 1012835 Parkyns Street, Los Angeles, California 90049, USA lIDepartment of Medicine, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, PO Box 19024, Seattle, Washington 98109-1024, USA 12Department of Immunohematology and Blood Bank, University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands Abstract. -
©Ferrata Storti Foundation
Haematologica 2000; 85:839-847 Transplantation & Cell Therapy original paper Allogeneic transplantation of G-CSF mobilized peripheral blood stem cells from unrelated donors: a retrospective analysis. MARTIN BORNHÄUSER,* CATRIN THEUSER,* SILKE SOUCEK,* KRISTINA HÖLIG,* THOMAS KLINGEBIEL,° WOLFGANG BLAU,# ALEXANDER FAUSER,# VOLKER RUNDE,@ WOLFGANG SCHWINGER,^ CLAUDIA RUTT,§ GERHARD EHNINGER* *Medizinische Klinik I, Universitätsklinikum Carl Gustav Carus, Dresden; °Kinderklinik Eberhard Karls Universität, Tübin- gen; #Klinik für Knochenmarktransplantation, Idar-Oberstein. @Klinik für Knochenmarktransplantation, Essen; ^Univer- sitätskinderklinik, Graz, Austria for the §Deutsche Knochenmarkspenderdatei, Tübingen (DKMS), Germany ABSTRACT Background and Objectives. Allogeneic peripheral either unmanipulated or CD34 selected. Prospective blood stem cell transplantation (PBSCT) from studies comparing BMT with PBSCT from unrelated matched siblings has lead to clinical results compa- donors are needed in defined disease categories. rable to those of standard bone marrow transplan- ©2000 Ferrata Storti Foundation tation (BMT). We report the outcome of 79 patients transplanted with PBSC from unrelated donors. Key words: allogeneic transplantation, peripheral blood stem Design and Methods. In 61 cases PBSC were used cells, unrelated donor for primary transplantation whereas 18 patients were treated for relapse or graft-failure. In 35 patients receiving primary transplants, T-cell deple- here are several reports on the outcome of tion (TCD) using CD34 -
American Osler Society
49th Annual Meeting of the American Osler Society Sir William Osler, quoting Leigh Hunt, “Abou Ben Adhem” Sunday, May 12th – Wednesday May 15th, 2019 Hotel Omni Mont-Royal Montréal, Canada Hotel Omni Mont-Royal 49th Annual Meeting of the AMERICAN OSLER SOCIETY Sunday, May 12th – Wednesday, May 15th, 2019 Hotel Omni Mont-Royal Montréal, Canada Credit: Karen Koshof The Osler Niche contains the ashes of Sir William Osler and Lady Osler, as well as those of Osler’s dear cousin and first Librarian of the Osler Library, W.W. Francis. The Niche was designed with Osler’s wishes in mind. Its realization was not far off the vision imagined by Osler’s alter ego Egerton Yorrick Davis in “Burrowings of a Bookworm”: I like to think of my few books in an alcove of a fire-proof library in some institution that I love; at the end of the alcove an open fire-place and a few easy chairs, and on the mantelpiece an urn with my ashes and my bust or portrait through which my astral self, like the Bishop at St. Praxed’s, could peek at the books I have loved, and enjoy the delight with which kindred souls still in the flesh would handle them. Course Objectives Upon conclusion of this program, participants should be able to: Describe new research findings in the history of medicine. Outline the evolution of medicine in a particular disease. List professional contributions made by others in medicine. Intended Audience The target audience includes physicians and others interested in Osler, medical history and any of the medically oriented humanities who research and write on a range of issues. -
Alumni Journal, School of Medicine Loma Linda University Publications
Loma Linda University TheScholarsRepository@LLU: Digital Archive of Research, Scholarship & Creative Works Alumni Journal, School of Medicine Loma Linda University Publications 9-2018 Alumni Journal - Volume 89, Number 3 Loma Linda University School of Medicine Follow this and additional works at: https://scholarsrepository.llu.edu/sm-alumni-journal Part of the Other Medicine and Health Sciences Commons Alumni JOURNALAlumni Association, School of Medicine of Loma Linda University September–December 2018 Graduation 2018 All the faces, residency information, and awards from graduation weekend INSIDE: Engaging the Next Generation • Department Reports: Radiation Medicine and Surgery TABLE of CONTENTS Alumni JOURNAL September–December 20172018 Though the campus may change, Volume 88,89, Number 3 Editor Burton A. Briggs ’66 Associate Editors you will always be family. DonnaRolanda L. R. Carlson Everett ’69 ’92 RolandaDarrell J. R. Ludders Everett ’67 ’92 Consulting Editor/Historian Dennis E. Park, MA, ’07-hon Managing Editor 18 Contributing Editor Chris Clouzet Karl P. Sandberg ’74 Assistant Editor ChristinaManaging Lee Editor Chris Clouzet Design & Layout ChrisDesign Clouzet & Layout CalvinChris Clouzet Chuang Calvin Chuang Advertising 21 AdvertisingNancy Yuen, MPW 26 CirculationAndrea Schröer CirculationA.T. Tuot A.T. Tuot Features Departments The Alumni JOURNAL is published 16 The Unwritten Curriculum 2 From the Editor Thethree Alumni times JOURNALa year by the is published threeAlumni times Association, a year by the H. Del Schutte Jr. ’84 on how he received 5 From the President more than just academic training at LLUSM AlumniSchool ofAssociation, Medicine of 6 From the Dean SchoolLoma Linda of Medicine University of 18 Engaging the Next Generation 11245 Anderson St., Suite 200 8 This and That Loma Linda University in the Pursuit of Medicine 11245Loma Linda, Anderson CA 92354 St., Suite 200 Gina J. -
College News
College news Meetings of Council Professors and Lecturers for 1975/76 were elected At the Extraordinary Meeting of the Council held (see p. i 68). on gth July Sir Rodney Smith KBE, President, was The following were elected as new Members of in the Chair. the Court of Examiners: Professor N L Browse Professor Emerich Polak, of Prague, was admitted and Mr C V Mann (General Surgery) and Mr to the Honorary Fellowship of the College. V T Hammond (Otolaryngology). In addition Mr Dr Denis Dooley, Dr Frederic Kohn, Dr R G W R I, B Beare, Mr C W S F Manning, Mr J P Ollerenshaw, Mr Giles Romanes, and Mr Norman Mitchell, and Mr J N Ward-McQuaid (General Rowe were admitted to the Fellowship by election. Surgery), Mr R F Macnab Jones (Otolaryngology), Diplomas of Fellowship were granted in accord- and Mr Lorimer Fison, Mr M J Gilkes, Mr C G ance with the pass list (see p. I 69). Tulloh, and Mr J Winstanley (Ophthalmology) were Diplomates were presented in order of medical re-elected for second terms of three years. and dental schools as follows: Fellows, Fellows in The Nuffield Prize was awarded to Dr David Dental Surgery, Fellows in the Faculty of Anaes- John Gwilt. thetists, Members, Licentiates in Dental Surgery. Sir Michael Woodruff FRS FRCS then delivered Faculty of Anaesthetists an address to the new diplomates (see p. I 66). It was noted that the following had been admit- ted to the Honorary Fellowship in the Faculty: Professor Sir Geoffrey Organe Dr Vernon Hall At the Quiarterly Meeting of the Council held on Professor W D M Paton FRS I oth July Sir Rodney Smith KBE was re-elected and that Dr S C Cullen, Professor J Severinghaus, President and Mr R H Franklin CBE and Mr R S and Dr C H Boyd had been admitted to the Handley OBE were re-elected as Vice-Presidents for FFARCS by election. -
Eg Phd, Mphil, Dclinpsychol
This thesis has been submitted in fulfilment of the requirements for a postgraduate degree (e.g. PhD, MPhil, DClinPsychol) at the University of Edinburgh. Please note the following terms and conditions of use: This work is protected by copyright and other intellectual property rights, which are retained by the thesis author, unless otherwise stated. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author. The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author. When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given. Factors influencing cold ischaemia time in deceased donor kidney transplants Sussie Shrestha MBBS, MRCS A thesis submitted for the degree of Doctor of Philosophy The University of Edinburgh 2018 ACKNOWLEDGEMENTS I am deeply indebted to my supervisor Professor Lorna Marson, without whose unwavering faith, encouragement and support throughout the course of the study this would not have come to fruition. I am also indebted to Professor Philip Dyer for his invaluable guidance, motivation and encouragement. I would like to express my gratitude to Professor Christopher Watson, Dr Craig Taylor and Professor John Forsythe for their help, advice, support and feedback that helped shape the study. My most sincere thanks to Ms Rachel Johnson, Ms Lisa Mumford and the NHS Blood and Transplant statistics team for their help and guidance with the data and statistical analysis. -
Jon Van Rood the Pioneer and His Personal View on the Early
Transplant Immunology 52 (2019) 1–26 Contents lists available at ScienceDirect Transplant Immunology journal homepage: www.elsevier.com/locate/trim Review Jon van Rood: The pioneer and his personal view on the early developments T of HLA and immunogenetics ⁎ Martine J. Jagera, , Anneke Brandb, Frans H.J. Claasc a Dept. of Ophthalmology, LUMC, Leiden, The Netherlands b Sanquin, Leiden, The Netherlands c Dept. of Immunohematology and Blood Transfusion, LUMC, Leiden, The Netherlands ABSTRACT A single observation in a patient with an unusual transfusion reaction led to a life-long fascination with immunogenetics, and a strong wish to improve the care for patients needing a transplantation. In 2017, Jon van Rood, one of the pioneers in the field of HLA and immunogenetics of transplantation, passed away. Several obituaries have appeared describing some of the highlights of his career. However, the details of the early developments leading among others to the routine use of HLA as an important parameter for donor selection in organ- and hematopoietic stem cell transplantation are largely unknown to the community. After his retirement as Chair of the Department of Immunohaematology and Blood Transfusion (IHB) in 1991, Jon van Rood wrote regularly in the “Crosstalk”, the departmental journal, and gave his personal view on the history of the discovery and implications of HLA. These autobiographic descriptions were originally written in Dutch and have been translated, while texts from other sources and the relevant references have been added to illustrate the historical perspective. This special issue of Transplant Immunology combines the autobiographic part, Jon's own version of the history, with other facts of his scientific life and the impact of his findings on the field of clinical transplantation. -
Global Kidney Exchange: Analysis and Background Papers from the Perspective of the Right to Health
University of Denver Digital Commons @ DU Anthropology: Undergraduate Student Scholarship Department of Anthropology 12-2017 Global Kidney Exchange: Analysis and Background Papers from the Perspective of the Right to Health Alejandro Cerón University of Denver Kiaryce Bey University of Denver Kelly Bonk University of Denver Ellie Carson University of Denver Emilia Chapa UnivFollowersity this of and Denv additionaler works at: https://digitalcommons.du.edu/anthropology_student Part of the International Public Health Commons, Medical Humanities Commons, and the Social and See next page for additional authors Cultural Anthropology Commons Recommended Citation Cerón, Alejandro; Bey, Kiaryce; Bonk, Kelly; Carson, Ellie; Chapa, Emilia; Cohen, Louisa; Crockford, Katie; Cuda, Rachel; Injac, Sebastian; Kirby, Kajsa; Leon-Alvarez, Daniela; Looney, Mackenzie; McBeth, Kendall; Pham, Winnie; Smith, Rose; Soltero Gutierrez, Margarita; Sugura, Katherine; Yu, Alexander; and Lazier, Flinn, "Global Kidney Exchange: Analysis and Background Papers from the Perspective of the Right to Health" (2017). Anthropology: Undergraduate Student Scholarship. 3. https://digitalcommons.du.edu/anthropology_student/3 This work is licensed under a Creative Commons Attribution 4.0 License. This Book is brought to you for free and open access by the Department of Anthropology at Digital Commons @ DU. It has been accepted for inclusion in Anthropology: Undergraduate Student Scholarship by an authorized administrator of Digital Commons @ DU. For more information, please contact