Electronic Supplementary Material (ESI) for Journal of Materials Chemistry B. This journal is © The Royal Society of Chemistry 2016
Supporting Information
An Octamolybdate-Metal Organic Framework Hybrid for the
Efficient Adsorption of Histidine-rich Proteins
Qing Chen, Meng-Meng Wang, Xue Hu, Xu-Wei Chen*, Jian-Hua Wang*
Research Center for Analytical Sciences, Department of Chemistry, College of
Sciences, Northeastern University, Box 332, Shenyang 110819, China
*E-mail address: [email protected] (X.W. Chen),
[email protected] (J.H. Wang).
1 Table S1. The number of total proteins identified in human plasma sample after depleting high abundant proteins by the Mo8O26@MIL-101 hybrid.
No. Peptides≥2. Protein Name MW [kDa] calc. pI Afamin OS=Homo sapiens 1 P43652 69.024 5.9 GN=AFM PE=1 SV=1 Alpha-1-acid glycoprotein 1 2 P02763 OS=Homo sapiens GN=ORM1 23.497 5.02 PE=1 SV=1 Alpha-1-acid glycoprotein 2 3 P19652 OS=Homo sapiens GN=ORM2 23.588 5.11 PE=1 SV=2 Alpha-1-antitrypsin OS=Homo 4 A0A024R6I7 sapiens GN=SERPINA1 PE=1 46.679 5.59 SV=1 Alpha-1-antitrypsin OS=Homo 5 P01009 sapiens GN=SERPINA1 PE=1 46.707 5.59 SV=3 Alpha-2-antiplasmin 6 P08697 OS=Homo sapiens 54.531 6.29 GN=SERPINF2 PE=1 SV=3 Alpha-2-macroglobulin 7 P01023 OS=Homo sapiens GN=A2M 163.188 6.46 PE=1 SV=3 Amyloid lambda 6 light chain variable region NEG 8 Q96JD2 11.901 4.94 (Fragment) OS=Homo sapiens PE=2 SV=1 Amyloid lambda 6 light chain variable region SAR 9 Q96JD0 12.287 5.01 (Fragment) OS=Homo sapiens PE=2 SV=1 Angiotensinogen variant 10 Q59EP2 (Fragment) OS=Homo sapiens 53.744 6.42 PE=2 SV=1 Anti-folate binding protein 11 A2NYQ9 (Fragment) OS=Homo sapiens 13.274 8.44 GN=HuVH8B VH PE=2 SV=1 Anti-H1N1 influenza HA 12 G3GAU4 11.599 7.96 kappa chain variable region
2 (Fragment) OS=Homo sapiens PE=2 SV=1 Anti-Influenza A hemagglutinin heavy chain 13 G1FM85 14.402 8.41 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Anti-mucin1 heavy chain 14 A2JA14 variable region (Fragment) 13.9 5.41 OS=Homo sapiens PE=2 SV=1 Anti-mucin1 light chain 15 A2JA19 variable region (Fragment) 11.651 8.91 OS=Homo sapiens PE=2 SV=1 Anti-mucin1 light chain 16 A2JA16 variable region (Fragment) 11.614 8.46 OS=Homo sapiens PE=2 SV=1 Anti-streptococcal/anti-myosin immunoglobulin kappa light 17 Q96SA9 chain variable region 11.513 8.85 (Fragment) OS=Homo sapiens PE=2 SV=1 Anti-streptococcal/anti-myosin immunoglobulin lambda light 18 Q96SB0 chain variable region 11.587 6.54 (Fragment) OS=Homo sapiens PE=2 SV=1 Anti-thyroglobulin heavy chain 19 Q8IZD7 variable region (Fragment) 13.893 8.46 OS=Homo sapiens PE=2 SV=1 Anti-TN-C scFv (Fragment) 20 A2KBC4 25.148 8.41 OS=Homo sapiens PE=2 SV=1 APOL1 protein (Fragment) 21 A5PL32 OS=Homo sapiens 48.486 7.17 GN=APOL1 PE=2 SV=1 Apolipoprotein A-I OS=Homo 22 P02647 sapiens GN=APOA1 PE=1 30.759 5.76 SV=1 Apolipoprotein A-II OS=Homo 23 V9GYM3 sapiens GN=APOA2 PE=1 14.905 8.27 SV=1 Apolipoprotein A-IV 24 P06727 OS=Homo sapiens 45.371 5.38 GN=APOA4 PE=1 SV=3 Apolipoprotein C-I, isoform 25 A0A024R0T8 9.326 8.47 CRA_a OS=Homo sapiens
3 GN=APOC1 PE=4 SV=1 Apolipoprotein D (Fragment) 26 C9JF17 OS=Homo sapiens GN=APOD 24.142 5.6 PE=1 SV=1 Apolipoprotein E OS=Homo 27 P02649 sapiens GN=APOE PE=1 36.132 5.73 SV=1 Apolipoprotein M OS=Homo 28 O95445 sapiens GN=APOM PE=1 21.239 6.01 SV=2 Attractin OS=Homo sapiens 29 O75882 158.432 7.31 GN=ATRN PE=1 SV=2 Beta-2-glycoprotein 1 30 P02749 OS=Homo sapiens GN=APOH 38.273 7.97 PE=1 SV=3 Biotinidase OS=Homo sapiens 31 P43251 61.093 6.25 GN=BTD PE=1 SV=2 Cadherin 5, type 2 preproprotein variant 32 Q59EA3 89.868 5.48 (Fragment) OS=Homo sapiens PE=2 SV=1 Carboxylic ester hydrolase 33 D3DNN4 OS=Homo sapiens GN=BCHE 72.836 7.55 PE=3 SV=1 CD5 antigen-like OS=Homo 34 O43866 sapiens GN=CD5L PE=1 38.063 5.47 SV=1 cDNA FLJ14473 fis, clone MAMMA1001080, highly similar to Homo sapiens 35 Q96K68 53.054 6.86 SNC73 protein (SNC73) mRNA OS=Homo sapiens PE=2 SV=1 CDNA FLJ26301 fis, clone 36 Q6ZP85 DMC07540 OS=Homo sapiens 25.787 8.38 PE=2 SV=1 CDNA FLJ26936 fis, clone 37 Q6ZNX5 RCT06808 OS=Homo sapiens 17.663 7.52 PE=2 SV=1 cDNA FLJ35730 fis, clone TESTI2003131, highly similar 38 B3KS79 to ALPHA-1- 50.596 5.63 ANTICHYMOTRYPSIN OS=Homo sapiens PE=2 SV=1
4 cDNA FLJ41981 fis, clone SMINT2011888, highly 39 Q6ZVX0 similar to Protein Tro alpha1 52.841 5.92 H,myeloma OS=Homo sapiens PE=2 SV=1 cDNA FLJ53691, highly 40 B4E1B2 similar to Serotransferrin 74.783 7.12 OS=Homo sapiens PE=2 SV=1 cDNA FLJ55606, highly similar to Alpha-2-HS- 41 B7Z8Q2 46.597 6.28 glycoprotein OS=Homo sapiens PE=2 SV=1 cDNA FLJ58124, highly similar to Complement factor I 42 B4DRF2 66.651 7.52 (EC 3.4.21.45) OS=Homo sapiens PE=2 SV=1 cDNA FLJ75881, highly similar to Homo sapiens 43 A8K6Q8 transferrin receptor (p90, 84.82 6.61 CD71) (TFRC), mRNA OS=Homo sapiens PE=2 SV=1 cDNA FLJ76826, highly similar to Homo sapiens 44 A8K5A4 ceruloplasmin (ferroxidase) 122.095 5.74 (CP), mRNA OS=Homo sapiens PE=2 SV=1 cDNA FLJ77835, highly similar to Homo sapiens complement component 1, s 45 A8K2N0 76.563 4.98 subcomponent (C1S), transcript variant 2, mRNA OS=Homo sapiens PE=2 SV=1 cDNA FLJ78071, highly similar to Human MHC class 46 A8K8Z4 III complement component C6 104.649 6.62 mRNA OS=Homo sapiens PE=2 SV=1 cDNA FLJ78207, highly similar to Human complement 47 A8K2T4 93.346 6.51 protein component C7 mRNA OS=Homo sapiens PE=2 SV=1 cDNA FLJ78387 OS=Homo 48 A8K008 51.564 8.16 sapiens PE=1 SV=1
5 cDNA FLJ90170 fis, clone MAMMA1000370, highly 49 Q8NCL6 similar to Ig alpha-1 chain C 53.19 6.52 region OS=Homo sapiens PE=2 SV=1 cDNA, FLJ93141, highly similar to Homo sapiens 50 B2R6V9 coagulation factor XIII, A1 83.189 6 polypeptide (F13A1), mRNA OS=Homo sapiens PE=2 SV=1 cDNA, FLJ93387, highly similar to Homo sapiens 51 B2R7D1 transglutaminase 4 (prostate) 77.08 6.76 (TGM4), mRNA OS=Homo sapiens PE=2 SV=1 cDNA, FLJ93914, highly similar to Homo sapiens 52 B2R8I2 histidine-rich glycoprotein 59.475 7.44 (HRG), mRNA OS=Homo sapiens PE=2 SV=1 cDNA, FLJ94361, highly similar to Homo sapiens serine (or cysteine) proteinase inhibitor, clade A(alpha-1 53 B2R9F2 45.066 6.04 antiproteinase, antitrypsin), member 6 (SERPINA6), mRNA OS=Homo sapiens PE=2 SV=1 cDNA, FLJ94686, highly similar to Homo sapiens 54 B2RA39 complement factor H-related 5 64.349 7.06 (CFHL5), mRNA OS=Homo sapiens PE=2 SV=1 Clusterin OS=Homo sapiens 55 P10909 52.461 6.27 GN=CLU PE=1 SV=1 Coagulation factor X 56 P00742 OS=Homo sapiens GN=F10 54.697 5.94 PE=1 SV=2 Coiled-coil domain-containing 57 Q8NCX0 protein 150 OS=Homo sapiens 128.681 7.02 GN=CCDC150 PE=1 SV=2 Cold agglutinin FS-1 L-chain 58 A2NB45 (Fragment) OS=Homo sapiens 12.38 8.48 PE=2 SV=1
6 Cold agglutinin FS-2 H-chain 59 A2NB44 (Fragment) OS=Homo sapiens 12.753 7.11 GN=IGH@ PE=2 SV=1 Complement C4-A OS=Homo 60 A0A0G2JPR0 192.754 7.03 sapiens GN=C4A PE=1 SV=1 Complement component 9, 61 A0A024R035 isoform CRA_a OS=Homo 63.163 5.52 sapiens GN=C9 PE=4 SV=1 Complement component C8 62 P07357 alpha chain OS=Homo sapiens 65.121 6.47 GN=C8A PE=1 SV=2 Cryocrystalglobulin CC1 heavy chain variable region 63 B1N7B6 13.184 8.48 (Fragment) OS=Homo sapiens PE=2 SV=1 Cryocrystalglobulin CC2 lambda light chain variable 64 B1N7B9 11.308 7.97 region (Fragment) OS=Homo sapiens PE=2 SV=1 C-type lectin domain family 3, A0A024R2Q member B, isoform CRA_a 65 22.522 5.67 7 OS=Homo sapiens GN=CLEC3B PE=4 SV=1 Cysteine-rich secretory protein 66 J3KPA1 3 OS=Homo sapiens 30.955 7.61 GN=CRISP3 PE=1 SV=1 Dermcidin OS=Homo sapiens 67 P81605 11.277 6.54 GN=DCD PE=1 SV=2 Dopamine beta-hydroxylase 68 P09172 OS=Homo sapiens GN=DBH 69.021 6.42 PE=1 SV=3 Dynein heavy chain 14, 69 Q0VDD8 axonemal OS=Homo sapiens 399.64 6.93 GN=DNAH14 PE=2 SV=3 Epididymis luminal protein 180 (Fragment) OS=Homo 70 B6EDE2 13.28 5.45 sapiens GN=HEL180 PE=2 SV=1 Epididymis luminal protein 71 V9HW68 214 OS=Homo sapiens 51.683 7.75 GN=HEL-214 PE=2 SV=1 Epididymis secretory sperm 72 V9HWD8 binding protein Li 163pA 54.22 5.86 OS=Homo sapiens GN=HEL-
7 S-163pA PE=2 SV=1 Epididymis secretory sperm binding protein Li 62p 73 V9HWA9 187.03 6.4 OS=Homo sapiens GN=HEL- S-62p PE=2 SV=1 F5-20 (Fragment) OS=Homo 74 A0N7I9 13.411 9.1 sapiens GN=F5-20 PE=2 SV=1 A0A0M3KK Fab Hu 15C1 Heavy chain 75 OS=Homo sapiens PE=1 SV=1 24.059 8.85 W6 Fibulin-1 OS=Homo sapiens 76 P23142 77.162 5.22 GN=FBLN1 PE=1 SV=4 FLJ00382 protein (Fragment) 77 Q8NF20 OS=Homo sapiens 52.892 8.66 GN=FLJ00382 PE=2 SV=1 FLJ00385 protein (Fragment) 78 Q8NF17 OS=Homo sapiens 56.075 7.59 GN=FLJ00385 PE=1 SV=1 Full-length cDNA clone CS0DD006YL02 of 79 Q86TT1 Neuroblastoma of Homo 41.247 6.79 sapiens (human) OS=Homo sapiens PE=2 SV=1 Gelsolin OS=Homo sapiens 80 P06396 85.644 6.28 GN=GSN PE=1 SV=1 Glutathione peroxidase 3 81 P22352 OS=Homo sapiens GN=GPX3 25.537 8.13 PE=1 SV=2 Haptoglobin OS=Homo 82 P00738 45.177 6.58 sapiens GN=HP PE=1 SV=1 Haptoglobin-related protein 83 P00739 OS=Homo sapiens GN=HPR 39.005 7.09 PE=2 SV=2 Heavy chain Fab (Fragment) 84 A2NYU7 13.983 9.25 OS=Homo sapiens PE=2 SV=1 Heavy chain Fab (Fragment) 85 A2NYU8 12.667 9.2 OS=Homo sapiens PE=2 SV=1 Heavy chain Fab (Fragment) 86 A2NYV1 14.271 6.54 OS=Homo sapiens PE=2 SV=1 Heavy chain Fab (Fragment) 87 A2NYV0 13.25 9.29 OS=Homo sapiens PE=2 SV=1 Heavy chain of factor I 88 Q6LAM1 (Fragment) OS=Homo sapiens 35.859 7.59 PE=2 SV=1
8 Heavy chain variable region 89 A2NXP8 (Fragment) OS=Homo sapiens 13.825 9.72 PE=2 SV=1 Hemoglobin, beta OS=Homo 90 D9YZU5 15.988 7.28 sapiens GN=HBB PE=3 SV=1 Hemopexin OS=Homo sapiens 91 P02790 51.643 7.02 GN=HPX PE=1 SV=2 Heparin cofactor 2 OS=Homo 92 P05546 sapiens GN=SERPIND1 PE=1 57.034 6.9 SV=3 High affinity copper uptake 93 O15431 protein 1 OS=Homo sapiens 21.076 7.42 GN=SLC31A1 PE=1 SV=1 Hornerin OS=Homo sapiens 94 Q86YZ3 282.228 10.04 GN=HRNR PE=1 SV=2 HRV Fab 027-VL (Fragment) 95 A2IPI6 12.375 9.41 OS=Homo sapiens PE=2 SV=1 Ig gamma-1 chain C region 96 A0A087X079 OS=Homo sapiens 51.88 8.07 GN=IGHG1 PE=1 SV=1 A0A087WYC Ig gamma-1 chain C region 97 OS=Homo sapiens 52.393 8.21 5 GN=IGHG1 PE=1 SV=1 A0A087WYE Ig gamma-1 chain C region 98 OS=Homo sapiens 52.077 7.55 1 GN=IGHG1 PE=1 SV=1 Ig gamma-1 chain C region 99 A0A087X010 OS=Homo sapiens 50.79 8.18 GN=IGHG1 PE=1 SV=1 Ig gamma-2 chain C region 100 P01859 OS=Homo sapiens 35.878 7.59 GN=IGHG2 PE=1 SV=2 A0A087WXL Ig gamma-3 chain C region 101 OS=Homo sapiens 56.853 8.25 8 GN=IGHG3 PE=1 SV=1 A0A0G2JPD Ig gamma-4 chain C region 102 (Fragment) OS=Homo sapiens 35.918 7.36 4 GN=IGHG4 PE=1 SV=2 A0A068LKQ Ig heavy chain variable region 103 (Fragment) OS=Homo sapiens 13.15 9.07 2 PE=2 SV=1 A0A068LKQ Ig heavy chain variable region 104 (Fragment) OS=Homo sapiens 13.626 8.69 5 PE=2 SV=1
9 A0A068LRX Ig heavy chain variable region 105 (Fragment) OS=Homo sapiens 11.209 9.5 1 PE=2 SV=1 Ig heavy chain variable region 106 A0A068LN03 (Fragment) OS=Homo sapiens 13.376 8.43 PE=2 SV=1 A0A068LKQ Ig heavy chain variable region 107 (Fragment) OS=Homo sapiens 13.345 5.99 0 PE=4 SV=1 Ig heavy chain V-I region V35 108 P23083 13 9.55 OS=Homo sapiens PE=1 SV=1 Ig heavy chain V-II region 109 P06331 ARH-77 OS=Homo sapiens 16.218 8.28 PE=4 SV=1 Ig heavy chain V-II region 110 P04438 SESS OS=Homo sapiens PE=2 16.312 7.09 SV=1 Ig heavy chain V-III region 111 P01767 BUT OS=Homo sapiens PE=1 12.371 9.25 SV=1 Ig heavy chain V-III region 112 P01768 CAM OS=Homo sapiens PE=1 13.659 9.63 SV=1 Ig heavy chain V-III region 113 P01769 GA OS=Homo sapiens PE=1 13.157 9.77 SV=1 Ig heavy chain V-III region 114 P01781 GAL OS=Homo sapiens PE=1 12.722 8.48 SV=1 Ig heavy chain V-III region 115 P80419 GAR OS=Homo sapiens PE=1 13.079 4.81 SV=1 Ig heavy chain V-III region 116 P01775 LAY OS=Homo sapiens PE=1 12.85 8.48 SV=1 Ig heavy chain V-III region 117 P01765 TIL OS=Homo sapiens PE=1 12.348 9.13 SV=1 Ig heavy chain V-III region 118 P01762 TRO OS=Homo sapiens PE=1 13.464 9.72 SV=1 Ig heavy chain V-III region 119 P01779 TUR OS=Homo sapiens PE=1 12.423 9.73 SV=1
10 Ig heavy chain V-III region 120 P01763 WEA OS=Homo sapiens PE=1 12.249 8.5 SV=1 A0A075B6H Ig kappa chain C region 121 (Fragment) OS=Homo sapiens 11.712 5.87 6 GN=IGKC PE=1 SV=1 Ig kappa chain C region 122 A0A087X130 OS=Homo sapiens GN=IGKC 25.12 6.32 PE=1 SV=1 A0A087WTX Ig kappa chain C region 123 OS=Homo sapiens GN=IGKC 25.608 7.97 5 PE=1 SV=1 Ig kappa chain V-I region 124 P04430 BAN OS=Homo sapiens PE=1 11.833 8.44 SV=1 Ig kappa chain V-I region DEE 125 P01597 11.654 9.36 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Gal 126 P01599 11.807 8.88 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Kue 127 P01604 12.119 8.81 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Lay 128 P01605 11.827 7.96 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Mev 129 P01612 11.863 6.57 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Ni 130 P01613 12.238 5.36 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region OU 131 P01606 11.77 9.91 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Scw 132 P01609 11.757 6 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Wes 133 P01611 11.601 7.28 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-ID region 16 134 P01601 (Fragment) OS=Homo sapiens 12.722 7.74 GN=IGKV1D-16 PE=4 SV=2 Ig kappa chain V-II region FR 135 P01615 12.652 7.94 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-II region 136 P01616 MIL OS=Homo sapiens PE=1 12.048 9.29 SV=1 Ig kappa chain V-III region B6 137 P01619 11.628 9.25 OS=Homo sapiens PE=1 SV=1
11 Ig kappa chain V-III region 138 P04207 CLL OS=Homo sapiens PE=4 14.266 8.51 SV=2 Ig kappa chain V-III region 139 P04206 GOL OS=Homo sapiens PE=1 11.823 9.25 SV=1 Ig kappa chain V-III region 140 P01621 NG9 (Fragment) OS=Homo 10.722 6.52 sapiens PE=2 SV=1 Ig kappa chain V-III region 141 P01624 POM OS=Homo sapiens PE=1 11.915 8.94 SV=1 Ig kappa chain V-III region 142 P01620 SIE OS=Homo sapiens PE=1 11.768 8.48 SV=1 Ig kappa chain V-IV region JI 143 P06313 14.623 6.58 OS=Homo sapiens PE=4 SV=1 Ig kappa chain V-IV region 144 P01625 Len OS=Homo sapiens PE=1 12.632 7.93 SV=2 Ig lambda chain V-I region 145 P01703 NEWM OS=Homo sapiens 10.898 9.29 PE=1 SV=1 Ig lambda chain V-II region 146 P01707 TRO OS=Homo sapiens PE=1 11.554 8.29 SV=1 Ig lambda chain V-III region 147 P01714 SH OS=Homo sapiens PE=1 11.386 6.52 SV=1 Ig lambda chain V-IV region 148 P06889 MOL OS=Homo sapiens PE=1 11.265 4.42 SV=1 Ig lambda chain V-V region 149 P01719 DEL OS=Homo sapiens PE=1 11.336 5.36 SV=1 Ig lambda-7 chain C region 150 A0A075B6L1 (Fragment) OS=Homo sapiens 11.3 8.29 GN=IGLC7 PE=1 SV=2 A0A087X2C Ig mu chain C region 151 OS=Homo sapiens GN=IGHM 64.066 7.14 0 PE=1 SV=1 A0A087WYJ Ig mu chain C region 152 OS=Homo sapiens GN=IGHM 65.66 6.95 9 PE=1 SV=1
12 IgG H chain OS=Homo 153 S6B291 50.838 7.77 sapiens PE=1 SV=1 IgG H chain OS=Homo 154 S6BGE0 32.161 7.85 sapiens PE=2 SV=1 IgG H chain OS=Homo 155 S6BGF5 25.584 8.56 sapiens PE=2 SV=1 IgG H chain OS=Homo 156 S6BAP0 24.023 8.54 sapiens PE=2 SV=1 IgG H chain OS=Homo 157 S6B2A6 32.147 7.25 sapiens PE=2 SV=1 IgG H chain OS=Homo 158 S6BGD4 25 9.48 sapiens PE=2 SV=1 IgG H chain OS=Homo 159 S6B2B6 29.342 8.68 sapiens PE=2 SV=1 IgG L chain OS=Homo sapiens 160 S6BGD6 24.808 7.24 PE=1 SV=1 IgG L chain OS=Homo sapiens 161 S6B2B0 23.102 8.53 PE=2 SV=1 IgG L chain OS=Homo sapiens 162 S6AWE6 22.891 8.43 PE=2 SV=1 IgG L chain OS=Homo sapiens 163 S6BAR0 23.107 7.69 PE=2 SV=1 IgG L chain OS=Homo sapiens 164 S6C4R7 22.499 8.24 PE=2 SV=1 IgG L chain OS=Homo sapiens 165 S6B2A1 20.36 5.52 PE=2 SV=1 IgG L chain OS=Homo sapiens 166 S6AWD3 19.929 8.91 PE=2 SV=1 IGH@ protein OS=Homo 167 Q6GMX6 sapiens GN=IGH@ PE=1 51.051 8.69 SV=1 IGH@ protein OS=Homo 168 Q6P089 sapiens GN=IGH@ PE=2 51.965 6.32 SV=1 A0A0F7T6Q IGHV1-2 protein (Fragment) 169 OS=Homo sapiens 11.904 9.29 1 GN=IGHV1-2 PE=4 SV=1 IGHV1-2 protein (Fragment) 170 A0A0F7T983 OS=Homo sapiens 11.185 8.12 GN=IGHV1-2 PE=4 SV=1 A0A0F7TD4 IGHV3-7 protein (Fragment) 171 OS=Homo sapiens 12.104 6.57 9 GN=IGHV3-7 PE=4 SV=1
13 IGHV4-31 protein (Fragment) 172 A0A0F7T8I6 OS=Homo sapiens 10.839 8.44 GN=IGHV4-31 PE=4 SV=1 IGHV4-39 protein (Fragment) 173 A0A0F7T931 OS=Homo sapiens 11.565 8.43 GN=IGHV4-39 PE=4 SV=1 A0A0F7TAV IGHV5-51 protein (Fragment) 174 OS=Homo sapiens 12.142 8.38 4 GN=IGHV5-51 PE=4 SV=1 IGK@ protein OS=Homo 175 Q6PIL8 sapiens GN=IGK@ PE=1 25.818 6.55 SV=1 IGK@ protein OS=Homo 176 Q6P5S8 sapiens GN=IGK@ PE=1 25.757 6.33 SV=1 IGL@ protein OS=Homo 177 Q8N355 sapiens GN=IGL@ PE=1 24.777 6.37 SV=1 IGL@ protein OS=Homo 178 Q6PIQ7 sapiens GN=IGL@ PE=1 25.005 7.97 SV=1 IGL@ protein OS=Homo 179 Q5FWF9 sapiens GN=IGL@ PE=1 24.779 5.59 SV=1 IGL@ protein OS=Homo 180 Q6IN99 sapiens GN=IGL@ PE=2 24.872 6.74 SV=1 IGL@ protein OS=Homo 181 Q567P1 sapiens GN=IGL@ PE=2 24.784 7.3 SV=1 IGL@ protein OS=Homo 182 Q6NS95 sapiens GN=IGL@ PE=2 25.132 6.67 SV=1 Immunglobulin heavy chain 183 Q0ZCI9 variable region (Fragment) 14.129 7.94 OS=Homo sapiens PE=1 SV=1 Immunglobulin heavy chain 184 Q0ZCH9 variable region (Fragment) 13.428 8.46 OS=Homo sapiens PE=4 SV=1 Immunglobulin heavy chain 185 Q0ZCH6 variable region (Fragment) 14.327 6.55 OS=Homo sapiens PE=4 SV=1 Immunglobulin heavy chain 186 Q0ZCI6 13.625 8.43 variable region (Fragment)
14 OS=Homo sapiens PE=4 SV=1 Immunglobulin heavy chain 187 Q0ZCJ1 variable region (Fragment) 13.377 8.43 OS=Homo sapiens PE=4 SV=1 Immunglobulin heavy chain 188 Q0ZCF6 variable region (Fragment) 14.538 8.78 OS=Homo sapiens PE=4 SV=1 Immunglobulin heavy chain 189 Q0ZCI2 variable region (Fragment) 13.316 9.1 OS=Homo sapiens PE=4 SV=1 Immunglobulin heavy chain 190 Q0ZCH8 variable region (Fragment) 12.459 7.96 OS=Homo sapiens PE=4 SV=1 Immunoglobulin heavy chain 191 Q9NPP6 variant (Fragment) OS=Homo 44.758 6.13 sapiens PE=2 SV=1 Immunoglobulin J chain 192 P01591 OS=Homo sapiens 18.087 5.24 GN=JCHAIN PE=1 SV=4 Immunoglobulin lambda-like A0A087WX4 polypeptide 5 OS=Homo 193 24.928 6.52 9 sapiens GN=IGLL5 PE=1 SV=1 Inter-alpha (Globulin) inhibitor H2, isoform CRA_a OS=Homo 194 D3DRR6 106.502 6.95 sapiens GN=ITIH2 PE=4 SV=1 Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo 195 P19827 101.326 6.79 sapiens GN=ITIH1 PE=1 SV=3 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo 196 Q06033 99.787 5.74 sapiens GN=ITIH3 PE=1 SV=2 ITIH4 protein OS=Homo 197 B7ZKJ8 sapiens GN=ITIH4 PE=1 103.816 6.89 SV=1 Keratin 1 OS=Homo sapiens 198 H6VRG1 66.086 8.12 GN=KRT1 PE=3 SV=1 Keratin 1 OS=Homo sapiens 199 H6VRG2 66.026 8.12 GN=KRT1 PE=3 SV=1 Keratin, type I cytoskeletal 10 200 P13645 58.792 5.21 OS=Homo sapiens
15 GN=KRT10 PE=1 SV=6 Keratin, type I cytoskeletal 13 201 P13646 OS=Homo sapiens 49.557 4.96 GN=KRT13 PE=1 SV=4 Keratin, type I cytoskeletal 16 202 P08779 OS=Homo sapiens 51.236 5.05 GN=KRT16 PE=1 SV=4 Keratin, type I cytoskeletal 9 203 P35527 OS=Homo sapiens GN=KRT9 62.027 5.24 PE=1 SV=3 Keratin, type II cytoskeletal 2 204 P35908 epidermal OS=Homo sapiens 65.393 8 GN=KRT2 PE=1 SV=2 Keratin, type II cytoskeletal 5 205 P13647 OS=Homo sapiens GN=KRT5 62.34 7.74 PE=1 SV=3 Keratin, type II cytoskeletal 6B 206 P04259 OS=Homo sapiens 60.03 8 GN=KRT6B PE=1 SV=5 Keratinocyte proline-rich 207 Q5T749 protein OS=Homo sapiens 64.093 8.27 GN=KPRP PE=1 SV=1 Kininogen 1, isoform CRA_a 208 D3DNU8 OS=Homo sapiens GN=KNG1 47.823 6.65 PE=4 SV=1 Lambda light chain of human immunoglobulin surface 209 C6KXN3 antigen-related protein 24.726 5.54 (Fragment) OS=Homo sapiens GN=IgLC-rG PE=1 SV=1 Lambda-chain (AA -20 to 215) 210 A2NUT2 24.639 7.62 OS=Homo sapiens PE=1 SV=1 Leucine-rich alpha-2- glycoprotein OS=Homo 211 P02750 38.154 6.95 sapiens GN=LRG1 PE=1 SV=2 Lumican OS=Homo sapiens 212 P51884 38.405 6.61 GN=LUM PE=1 SV=2 Mutant hemoglobin alpha 2 A0A0K2BM globin chain OS=Homo 213 15.248 8.68 D8 sapiens GN=HBA2 PE=3 SV=1 Myosin-reactive 214 Q9UL72 12.864 6.58 immunoglobulin heavy chain
16 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin heavy chain 215 Q9UL90 12.429 8.44 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin heavy chain 216 Q9UL71 13.145 7.12 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin heavy chain 217 Q9UL88 14.133 9.63 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin heavy chain 218 Q9UL89 12.597 9.1 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin heavy chain 219 Q9UL84 13.571 8.46 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin kappa chain 220 Q9UL85 11.754 8.51 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin kappa chain 221 Q9UL86 11.921 7.96 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin light chain 222 Q9UL70 11.626 9.36 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 Myosin-reactive immunoglobulin light chain 223 Q9UL82 11.438 6.6 variable region (Fragment) OS=Homo sapiens PE=2 SV=1 N-acetylmuramoyl-L-alanine 224 Q96PD5 amidase OS=Homo sapiens 62.178 7.55 GN=PGLYRP2 PE=1 SV=1 NADH-ubiquinone 225 W8DAS2 oxidoreductase chain 5 66.992 9.03 OS=Homo sapiens GN=ND5
17 PE=3 SV=1 NANUC-1 heavy chain 226 A2NKM6 (Fragment) OS=Homo sapiens 13.095 9.95 PE=2 SV=1 Plasma kallikrein (Fragment) 227 H0YAC1 OS=Homo sapiens 76.833 8.06 GN=KLKB1 PE=1 SV=1 Plasma protease C1 inhibitor 228 E9PGN7 OS=Homo sapiens 59.455 6.76 GN=SERPING1 PE=1 SV=1 Protein AMBP OS=Homo 229 P02760 sapiens GN=AMBP PE=1 38.974 6.25 SV=1 A0A0C4DH3 Protein IGHV1-18 (Fragment) 230 OS=Homo sapiens 12.812 8.84 1 GN=IGHV1-18 PE=1 SV=1 A0A0C4DH3 Protein IGHV1-24 (Fragment) 231 OS=Homo sapiens 12.816 5.16 3 GN=IGHV1-24 PE=4 SV=1 A0A0A0MS1 Protein IGHV1-45 (Fragment) 232 OS=Homo sapiens 13.5 9.1 4 GN=IGHV1-45 PE=1 SV=1 Protein IGHV1-69-2 233 A0A0B4J2H0 (Fragment) OS=Homo sapiens 12.652 8.47 GN=IGHV1-69-2 PE=4 SV=1 Protein IGHV1OR15-1 A0A075B7D (Fragment) OS=Homo sapiens 234 13.003 9.13 0 GN=IGHV1OR15-1 PE=4 SV=1 Protein IGHV2-26 (Fragment) 235 A0A0B4J1V2 OS=Homo sapiens 13.174 8.29 GN=IGHV2-26 PE=1 SV=1 A0A0A0MS1 Protein IGHV3-13 (Fragment) 236 OS=Homo sapiens 12.498 7.08 1 GN=IGHV3-13 PE=1 SV=1 A0A0C4DH3 Protein IGHV3-20 (Fragment) 237 OS=Homo sapiens 12.709 7.99 2 GN=IGHV3-20 PE=1 SV=1 A0A0C4DH3 Protein IGHV3-35 (Fragment) 238 OS=Homo sapiens 12.802 7.88 5 GN=IGHV3-35 PE=1 SV=1 A0A0C4DH3 Protein IGHV3-38 (Fragment) 239 OS=Homo sapiens 12.75 9.25 6 GN=IGHV3-38 PE=1 SV=1
18 A0A087WW Protein IGHV3-64 OS=Homo 240 sapiens GN=IGHV3-64 PE=4 8.3 8.73 F0 SV=1 A0A087WW Protein IGHV3-72 OS=Homo 241 sapiens GN=IGHV3-72 PE=1 11.16 7.97 89 SV=1 Protein IGHV3-74 (Fragment) 242 A0A0B4J1X5 OS=Homo sapiens 12.831 8.66 GN=IGHV3-74 PE=1 SV=1 Protein IGHV3OR16-10 (Fragment) OS=Homo sapiens 243 A0A075B7F0 12.571 8.66 GN=IGHV3OR16-10 PE=1 SV=1 Protein IGHV3OR16-12 (Fragment) OS=Homo sapiens 244 A0A075B7B8 12.866 6.51 GN=IGHV3OR16-12 PE=1 SV=1 A0A0C4DH3 Protein IGHV4-28 (Fragment) 245 OS=Homo sapiens 13.116 9.29 4 GN=IGHV4-28 PE=1 SV=1 A0A087WSY Protein IGHV4-31 (Fragment) 246 OS=Homo sapiens 13.017 9.67 4 GN=IGHV4-31 PE=4 SV=1 A0A0C4DH3 Protein IGHV5-51 (Fragment) 247 OS=Homo sapiens 12.666 8.27 8 GN=IGHV5-51 PE=1 SV=1 A0A0A0MT6 Protein IGKJ4 (Fragment) 248 OS=Homo sapiens GN=IGKJ4 1.249 8.84 9 PE=1 SV=1 A0A0A0MT7 Protein IGKV1-16 (Fragment) 249 OS=Homo sapiens 12.61 8.16 4 GN=IGKV1-16 PE=1 SV=1 A0A087WZH Protein IGKV1-33 OS=Homo 250 sapiens GN=IGKV1D-33 11.835 5.34 9 PE=4 SV=1 A0A087WW Protein IGKV1-8 OS=Homo 251 sapiens GN=IGKV1-8 PE=4 25.555 8.5 V8 SV=1 Protein IGKV2D-24 252 A0A075B6R9 (Fragment) OS=Homo sapiens 13.071 8.87 GN=IGKV2D-24 PE=4 SV=1 Protein IGKV2D-29 253 A0A087X0P6 OS=Homo sapiens 11.185 5.94 GN=IGKV2D-29 PE=1 SV=1
19 A0A087WZ Protein IGKV3-11 OS=Homo 254 sapiens GN=IGKV3-11 PE=4 25.585 6.01 W8 SV=1 A0A075B6H Protein IGKV3-7 (Fragment) 255 OS=Homo sapiens 12.775 5.25 7 GN=IGKV3-7 PE=4 SV=1 A0A0C4DH2 Protein IGKV3D-20 256 (Fragment) OS=Homo sapiens 12.507 4.59 5 GN=IGKV3D-20 PE=1 SV=1 A0A0A0MT3 Protein IGKV6D-21 257 (Fragment) OS=Homo sapiens 12.332 7.28 6 GN=IGKV6D-21 PE=4 SV=1 Protein IGLV10-54 (Fragment) 258 A0A075B6I4 OS=Homo sapiens 12.387 8.03 GN=IGLV10-54 PE=1 SV=1 Protein IGLV3-19 (Fragment) 259 A0A075B6J8 OS=Homo sapiens 12.035 4.96 GN=IGLV3-19 PE=1 SV=1 Protein IGLV3-27 (Fragment) 260 A0A075B6J3 OS=Homo sapiens 12.157 5.01 GN=IGLV3-27 PE=1 SV=1 Protein IGLV4-60 (Fragment) 261 A0A075B6I1 OS=Homo sapiens 12.979 6.25 GN=IGLV4-60 PE=1 SV=1 A0A087WSX Protein IGLV5-45 (Fragment) 262 OS=Homo sapiens 13.153 7.2 0 GN=IGLV5-45 PE=1 SV=1 Prothrombin OS=Homo 263 P00734 69.992 5.9 sapiens GN=F2 PE=1 SV=2 Protocadherin alpha-C1 264 Q9H158 OS=Homo sapiens 103.877 5.21 GN=PCDHAC1 PE=2 SV=2 Putative matrix cell adhesion 265 Q96QS0 molecule-3 OS=Homo sapiens 17.485 9.29 PE=2 SV=1 Putative uncharacterized protein DKFZp686C02220 266 Q6N091 (Fragment) OS=Homo sapiens 54.126 6.34 GN=DKFZp686C02220 PE=2 SV=1 Putative uncharacterized protein DKFZp686C11235 267 Q6MZV7 52.088 7.58 OS=Homo sapiens GN=DKFZp686C11235 PE=2
20 SV=1 Putative uncharacterized protein DKFZp686C15213 268 Q6MZU6 OS=Homo sapiens 51.066 7.71 GN=DKFZp686C15213 PE=2 SV=1 Putative uncharacterized protein DKFZp686G11190 269 Q6MZQ6 OS=Homo sapiens 52.01 8.06 GN=DKFZp686G11190 PE=2 SV=1 Putative uncharacterized protein DKFZp686I04196 270 Q6N093 (Fragment) OS=Homo sapiens 46.032 7.59 GN=DKFZp686I04196 PE=2 SV=1 Putative uncharacterized protein DKFZp686K03196 271 Q6N095 OS=Homo sapiens 52.327 8.57 GN=DKFZp686K03196 PE=1 SV=1 Putative uncharacterized protein DKFZp686K18196 272 Q6N092 (Fragment) OS=Homo sapiens 56.388 6.93 GN=DKFZp686K18196 PE=2 SV=1 Putative uncharacterized protein DKFZp686L19235 273 Q6MZV6 OS=Homo sapiens 51.606 5.77 GN=DKFZp686L19235 PE=2 SV=1 Putative uncharacterized protein DKFZp686M24218 274 Q6MZX7 OS=Homo sapiens 52.387 7.77 GN=DKFZp686M24218 PE=2 SV=1 Putative uncharacterized protein DKFZp686N02209 275 Q7Z351 OS=Homo sapiens 52.819 8.48 GN=DKFZp686N02209 PE=2 SV=1 Putative uncharacterized 276 Q6N094 protein DKFZp686O01196 52.579 8.18 OS=Homo sapiens
21 GN=DKFZp686O01196 PE=2 SV=1 Putative uncharacterized protein DKFZp686P15220 277 Q6N089 OS=Homo sapiens 51.692 7.93 GN=DKFZp686P15220 PE=1 SV=1 Putative uncharacterized protein DKFZp781M0386 278 Q5CZ94 OS=Homo sapiens 24.986 7.27 GN=DKFZp781M0386 PE=2 SV=1 Retinol-binding protein 4 279 P02753 OS=Homo sapiens GN=RBP4 22.995 6.07 PE=1 SV=3 Rheumatoid factor C6 light chain (Fragment) OS=Homo 280 A0N5G1 12.52 8.46 sapiens GN=V
22 PE=2 SV=1 Rheumatoid factor RF-IP9 289 A2J1M2 (Fragment) OS=Homo sapiens 10.542 9.17 PE=2 SV=1 Selenoprotein P OS=Homo 290 P49908 sapiens GN=SEPP1 PE=1 43.156 7.87 SV=3 Serotransferrin (Fragment) 291 C9JVG0 OS=Homo sapiens GN=TF 14.681 7.14 PE=1 SV=1 Serotransferrin (Fragment) 292 C9JB55 OS=Homo sapiens GN=TF 7.985 4.72 PE=1 SV=6 Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), 293 A0A024R6I9 48.511 7.75 member 4, isoform CRA_a OS=Homo sapiens GN=SERPINA4 PE=3 SV=1 Serpin peptidase inhibitor, clade C (Antithrombin), 294 A0A024R944 member 1, isoform CRA_a 52.569 6.71 OS=Homo sapiens GN=SERPINC1 PE=3 SV=1 Serum albumin OS=Homo 295 B7WNR0 56.175 7.14 sapiens GN=ALB PE=1 SV=1 Serum albumin OS=Homo 296 P02768 69.321 6.28 sapiens GN=ALB PE=1 SV=2 Serum paraoxonase/arylesterase 1 297 P27169 39.706 5.22 OS=Homo sapiens GN=PON1 PE=1 SV=3 Single chain Fv (Fragment) 298 Q9HCC1 12.235 8.47 OS=Homo sapiens PE=1 SV=1 Single-chain Fv (Fragment) 299 Q65ZC9 OS=Homo sapiens GN=scFv 25.554 9.11 PE=2 SV=1 Solute carrier family 2, facilitated glucose transporter 300 P11168 57.452 7.97 member 2 OS=Homo sapiens GN=SLC2A2 PE=1 SV=1 A0A087WU T-cell receptor gamma chain C 301 region 1 OS=Homo sapiens 34.816 7.99 A9 GN=TRGC1 PE=4 SV=1
23 Thyroxine-binding globulin 302 P05543 OS=Homo sapiens 46.295 6.3 GN=SERPINA7 PE=1 SV=2 Transferrin variant (Fragment) 303 Q53H26 77.03 7.03 OS=Homo sapiens PE=2 SV=1 Transmembrane protein 198 304 Q66K66 OS=Homo sapiens 39.449 9.92 GN=TMEM198 PE=1 SV=1 A0A087WT5 Transthyretin OS=Homo 305 sapiens GN=TTR PE=1 SV=1 20.133 5.33 9 A0A0G2JRQ Uncharacterized protein 306 (Fragment) OS=Homo sapiens 12.74 8.29 6 PE=1 SV=2 Uncharacterized protein 307 Q8TBD0 (Fragment) OS=Homo sapiens 14.003 7.9 PE=2 SV=1 Uncharacterized protein 308 A0A0J9YX35 (Fragment) OS=Homo sapiens 12.814 7.85 PE=4 SV=1 Uncharacterized protein 309 Q68DL7 C18orf63 OS=Homo sapiens 77.181 9.8 GN=C18orf63 PE=2 SV=2 Uncharacterized protein 310 Q8TCD0 26.218 8.06 OS=Homo sapiens PE=1 SV=1 Uncharacterized protein 311 B4E1Z4 140.853 7.18 OS=Homo sapiens PE=1 SV=1 Uncharacterized protein 312 Q6GMV8 24.894 6.67 OS=Homo sapiens PE=2 SV=1 Uncharacterized protein 313 Q8NEJ1 25.008 7.69 OS=Homo sapiens PE=2 SV=1 Uncharacterized protein 314 Q7Z2U7 24.999 6.38 OS=Homo sapiens PE=2 SV=1 Uncharacterized protein 315 A0A5E4 24.731 5.94 OS=Homo sapiens PE=2 SV=1 Uncharacterized protein 316 Q569I7 20.655 5.27 OS=Homo sapiens PE=2 SV=1 V1-17 protein (Fragment) 317 A2MYD0 OS=Homo sapiens GN=V1-17 10.39 5.19 PE=4 SV=1 V1-3 protein (Fragment) 318 Q5NV84 OS=Homo sapiens GN=V1-3 10.486 7.06 PE=4 SV=1
24 V2-17 protein (Fragment) 319 Q5NV90 OS=Homo sapiens GN=V2-17 10.399 4.59 PE=1 SV=1 V2-7 protein (Fragment) 320 A2MYD4 OS=Homo sapiens GN=V2-7 10.346 5.01 PE=4 SV=1 V5-6 protein (Fragment) 321 Q5NV92 OS=Homo sapiens GN=V5-6 10.567 6.27 PE=4 SV=1 Variable immnoglobulin anti- estradiol heavy chain 322 A2NZ55 13.913 8.79 (Fragment) OS=Homo sapiens PE=2 SV=1 Vh1-D-J3-region (Fragment) 323 A2N011 13.743 8.47 OS=Homo sapiens PE=2 SV=1 VH3 protein (Fragment) 324 Q9Y509 OS=Homo sapiens GN=VH3 15.759 8.38 PE=2 SV=1 VH4 heavy chain variable 325 O95973 region (Fragment) OS=Homo 16.305 8.47 sapiens GN=IGM PE=2 SV=1 VH6DJ protein (Fragment) 326 A2N0U2 OS=Homo sapiens 12.543 8.47 GN=VH6DJ PE=2 SV=1 VH6DJ protein (Fragment) 327 A2N0T1 OS=Homo sapiens 13.012 8.47 GN=VH6DJ PE=2 SV=1 VH6DJ protein (Fragment) 328 A2N0U4 OS=Homo sapiens 11.793 5.36 GN=VH6DJ PE=2 SV=1 VH6DJ protein (Fragment) 329 A2N0T9 OS=Homo sapiens 12.784 9.2 GN=VH6DJ PE=2 SV=1 VH6DJ protein (Fragment) 330 A2N0U1 OS=Homo sapiens 12.622 8.48 GN=VH6DJ PE=2 SV=1 Vitamin D-binding protein 331 D6RF35 OS=Homo sapiens GN=GC 52.986 5.52 PE=1 SV=1 Vitronectin OS=Homo sapiens 332 D9ZGG2 54.271 5.8 GN=VTN PE=4 SV=1 VK3 protein (Fragment) 333 A2N2F4 OS=Homo sapiens GN=VK3 11.879 9.51 PE=2 SV=1
25 VL4 protein (Fragment) 334 A2N2W9 OS=Homo sapiens GN=VL4 8.142 7.96 PE=4 SV=1 Zinc-alpha-2-glycoprotein 335 P25311 OS=Homo sapiens 34.237 6.05 GN=AZGP1 PE=1 SV=2
Table S2. The number of total proteins identified in raw human plasma sample.
No. Peptides≥2. Protein Name MW [kDa] calc. pI 72 kDa inositol polyphosphate 5-phosphatase OS=Homo 1 Q9NRR6 70.162 8.95 sapiens GN=INPP5E PE=1 SV=2 Acidic leucine-rich nuclear phosphoprotein 32 family 2 O43423 26.746 4.21 member C OS=Homo sapiens GN=ANP32C PE=2 SV=1 Afamin OS=Homo sapiens 3 P43652 69.024 5.9 GN=AFM PE=1 SV=1 Alpha-1-acid glycoprotein 1 4 P02763 OS=Homo sapiens GN=ORM1 23.497 5.02 PE=1 SV=1 Alpha-1-acid glycoprotein 2 5 P19652 OS=Homo sapiens GN=ORM2 23.588 5.11 PE=1 SV=2 Alpha-1-antichymotrypsin 6 P01011 OS=Homo sapiens 47.621 5.52 GN=SERPINA3 PE=1 SV=2 Alpha-1-antitrypsin OS=Homo 7 P01009 sapiens GN=SERPINA1 PE=1 46.707 5.59 SV=3 Alpha-1B-glycoprotein 8 P04217 OS=Homo sapiens GN=A1BG 54.22 5.86 PE=1 SV=4 Alpha-2-antiplasmin 9 P08697 OS=Homo sapiens 54.531 6.29 GN=SERPINF2 PE=1 SV=3 Alpha-2-HS-glycoprotein 10 P02765 OS=Homo sapiens GN=AHSG 39.3 5.72 PE=1 SV=1 11 P01023 Alpha-2-macroglobulin 163.188 6.46
26 OS=Homo sapiens GN=A2M PE=1 SV=3 Angiotensinogen OS=Homo 12 P01019 53.121 6.32 sapiens GN=AGT PE=1 SV=1 Antithrombin-III OS=Homo 13 P01008 sapiens GN=SERPINC1 PE=1 52.569 6.71 SV=1 Apolipoprotein A-I OS=Homo 14 P02647 sapiens GN=APOA1 PE=1 30.759 5.76 SV=1 Apolipoprotein A-II OS=Homo 15 P02652 sapiens GN=APOA2 PE=1 11.168 6.62 SV=1 Apolipoprotein A-IV 16 P06727 OS=Homo sapiens 45.371 5.38 GN=APOA4 PE=1 SV=3 Apolipoprotein B-100 17 P04114 OS=Homo sapiens GN=APOB 515.283 7.05 PE=1 SV=2 Apolipoprotein C-I OS=Homo 18 P02654 sapiens GN=APOC1 PE=1 9.326 8.47 SV=1 Apolipoprotein C-II OS=Homo 19 P02655 sapiens GN=APOC2 PE=1 11.277 4.72 SV=1 Apolipoprotein C-III 20 P02656 OS=Homo sapiens 10.845 5.41 GN=APOC3 PE=1 SV=1 Apolipoprotein C-IV 21 P55056 OS=Homo sapiens 14.543 8.92 GN=APOC4 PE=1 SV=1 Apolipoprotein D OS=Homo 22 P05090 sapiens GN=APOD PE=1 21.262 5.15 SV=1 Apolipoprotein E OS=Homo 23 P02649 sapiens GN=APOE PE=1 36.132 5.73 SV=1 Apolipoprotein F OS=Homo 24 Q13790 sapiens GN=APOF PE=1 35.377 5.64 SV=2 Apolipoprotein L1 OS=Homo 25 O14791 sapiens GN=APOL1 PE=1 43.947 5.81 SV=5
27 Apolipoprotein M OS=Homo 26 O95445 sapiens GN=APOM PE=1 21.239 6.01 SV=2 Apolipoprotein(a) OS=Homo 27 P08519 500.995 5.88 sapiens GN=LPA PE=1 SV=1 ATP-binding cassette sub- family A member 13 28 Q86UQ4 575.791 6.46 OS=Homo sapiens GN=ABCA13 PE=2 SV=3 ATP-binding cassette sub- family B member 9 OS=Homo 29 Q9NP78 84.421 7.93 sapiens GN=ABCB9 PE=1 SV=1 Attractin OS=Homo sapiens 30 O75882 158.432 7.31 GN=ATRN PE=1 SV=2 Beta-2-glycoprotein 1 31 P02749 OS=Homo sapiens GN=APOH 38.273 7.97 PE=1 SV=3 Beta-2-microglobulin 32 P61769 OS=Homo sapiens GN=B2M 13.706 6.52 PE=1 SV=1 Beta-Ala-His dipeptidase 33 Q96KN2 OS=Homo sapiens 56.67 5.3 GN=CNDP1 PE=1 SV=4 Biotinidase OS=Homo sapiens 34 P43251 61.093 6.25 GN=BTD PE=1 SV=2 C4b-binding protein alpha 35 P04003 chain OS=Homo sapiens 66.989 7.3 GN=C4BPA PE=1 SV=2 C4b-binding protein beta chain 36 P20851 OS=Homo sapiens 28.338 5.14 GN=C4BPB PE=1 SV=1 Cadherin-5 OS=Homo sapiens 37 P33151 87.474 5.43 GN=CDH5 PE=1 SV=5 Carbonic anhydrase 1 38 P00915 OS=Homo sapiens GN=CA1 28.852 7.12 PE=1 SV=2 Carbonic anhydrase 6 39 P23280 OS=Homo sapiens GN=CA6 35.345 7.02 PE=1 SV=3 Carboxypeptidase B2 40 Q96IY4 OS=Homo sapiens GN=CPB2 48.393 7.71 PE=1 SV=2
28 Carboxypeptidase N catalytic 41 P15169 chain OS=Homo sapiens 52.253 7.34 GN=CPN1 PE=1 SV=1 Carboxypeptidase N subunit 2 42 P22792 OS=Homo sapiens GN=CPN2 60.518 5.99 PE=1 SV=3 CD5 antigen-like OS=Homo 43 O43866 sapiens GN=CD5L PE=1 38.063 5.47 SV=1 Ceruloplasmin OS=Homo 44 P00450 122.128 5.72 sapiens GN=CP PE=1 SV=1 Cholesteryl ester transfer 45 P11597 protein OS=Homo sapiens 54.721 6.09 GN=CETP PE=1 SV=2 Cholinesterase OS=Homo 46 P06276 sapiens GN=BCHE PE=1 68.374 7.42 SV=1 Clusterin OS=Homo sapiens 47 P10909 52.461 6.27 GN=CLU PE=1 SV=1 Coagulation factor IX 48 P00740 OS=Homo sapiens GN=F9 51.745 5.47 PE=1 SV=2 Coagulation factor V 49 P12259 OS=Homo sapiens GN=F5 251.546 6.05 PE=1 SV=4 Coagulation factor X 50 P00742 OS=Homo sapiens GN=F10 54.697 5.94 PE=1 SV=2 Coagulation factor XI 51 P03951 OS=Homo sapiens GN=F11 70.064 8.1 PE=1 SV=1 Coagulation factor XII 52 P00748 OS=Homo sapiens GN=F12 67.748 7.74 PE=1 SV=3 Coagulation factor XIII A 53 P00488 chain OS=Homo sapiens 83.215 6.09 GN=F13A1 PE=1 SV=4 Coagulation factor XIII B 54 P05160 chain OS=Homo sapiens 75.461 6.39 GN=F13B PE=1 SV=3 Collectin-11 OS=Homo 55 Q9BWP8 sapiens GN=COLEC11 PE=1 28.647 5.41 SV=1
29 Complement C1q subcomponent subunit A 56 P02745 26 9.11 OS=Homo sapiens GN=C1QA PE=1 SV=2 Complement C1q subcomponent subunit B 57 P02746 26.704 8.63 OS=Homo sapiens GN=C1QB PE=1 SV=3 Complement C1q subcomponent subunit C 58 P02747 25.757 8.41 OS=Homo sapiens GN=C1QC PE=1 SV=3 Complement C1r 59 P00736 subcomponent OS=Homo 80.067 6.21 sapiens GN=C1R PE=1 SV=2 Complement C1r subcomponent-like protein 60 Q9NZP8 53.464 7.2 OS=Homo sapiens GN=C1RL PE=1 SV=2 Complement C1s 61 P09871 subcomponent OS=Homo 76.635 4.96 sapiens GN=C1S PE=1 SV=1 Complement C2 OS=Homo 62 P06681 83.214 7.42 sapiens GN=C2 PE=1 SV=2 Complement C3 OS=Homo 63 P01024 187.03 6.4 sapiens GN=C3 PE=1 SV=2 Complement C4-A OS=Homo 64 P0C0L4 192.664 7.08 sapiens GN=C4A PE=1 SV=2 Complement C4-B OS=Homo 65 P0C0L5 192.631 7.27 sapiens GN=C4B PE=1 SV=2 Complement C5 OS=Homo 66 P01031 188.186 6.52 sapiens GN=C5 PE=1 SV=4 Complement component C6 67 P13671 OS=Homo sapiens GN=C6 104.718 6.76 PE=1 SV=3 Complement component C7 68 P10643 OS=Homo sapiens GN=C7 93.457 6.48 PE=1 SV=2 Complement component C8 69 P07357 alpha chain OS=Homo sapiens 65.121 6.47 GN=C8A PE=1 SV=2 Complement component C8 70 P07358 beta chain OS=Homo sapiens 67.003 8.13 GN=C8B PE=1 SV=3
30 Complement component C8 71 P07360 gamma chain OS=Homo 22.264 8.31 sapiens GN=C8G PE=1 SV=3 Complement component C9 72 P02748 OS=Homo sapiens GN=C9 63.133 5.59 PE=1 SV=2 Complement factor B 73 P00751 OS=Homo sapiens GN=CFB 85.479 7.06 PE=1 SV=2 Complement factor H 74 P08603 OS=Homo sapiens GN=CFH 139.005 6.61 PE=1 SV=4 Complement factor H-related 75 Q03591 protein 1 OS=Homo sapiens 37.626 7.39 GN=CFHR1 PE=1 SV=2 Complement factor H-related 76 Q9BXR6 protein 5 OS=Homo sapiens 64.377 7.06 GN=CFHR5 PE=1 SV=1 Complement factor I 77 P05156 OS=Homo sapiens GN=CFI 65.707 7.5 PE=1 SV=2 Corticosteroid-binding 78 P08185 globulin OS=Homo sapiens 45.112 6.04 GN=SERPINA6 PE=1 SV=1 Cysteine-rich secretory protein 79 P54108 3 OS=Homo sapiens 27.612 7.8 GN=CRISP3 PE=1 SV=1 Dedicator of cytokinesis 80 Q8NF50 protein 8 OS=Homo sapiens 238.377 6.87 GN=DOCK8 PE=1 SV=3 Dopamine beta-hydroxylase 81 P09172 OS=Homo sapiens GN=DBH 69.021 6.42 PE=1 SV=3 EGF-containing fibulin-like extracellular matrix protein 1 82 Q12805 54.604 5.07 OS=Homo sapiens GN=EFEMP1 PE=1 SV=2 Extracellular matrix protein 1 83 Q16610 OS=Homo sapiens GN=ECM1 60.635 6.71 PE=1 SV=2 Fetuin-B OS=Homo sapiens 84 Q9UGM5 42.028 6.83 GN=FETUB PE=1 SV=2 Fibrinogen alpha chain 85 P02671 94.914 6.01 OS=Homo sapiens GN=FGA
31 PE=1 SV=2 Fibrinogen beta chain 86 P02675 OS=Homo sapiens GN=FGB 55.892 8.27 PE=1 SV=2 Fibrinogen gamma chain 87 P02679 OS=Homo sapiens GN=FGG 51.479 5.62 PE=1 SV=3 Fibronectin OS=Homo sapiens 88 P02751 262.46 5.71 GN=FN1 PE=1 SV=4 Fibulin-1 OS=Homo sapiens 89 P23142 77.162 5.22 GN=FBLN1 PE=1 SV=4 Ficolin-2 OS=Homo sapiens 90 Q15485 33.98 6.77 GN=FCN2 PE=1 SV=2 Ficolin-3 OS=Homo sapiens 91 O75636 32.882 6.67 GN=FCN3 PE=1 SV=2 Forkhead box protein P4 92 Q8IVH2 OS=Homo sapiens 73.443 6.4 GN=FOXP4 PE=1 SV=1 Galectin-3-binding protein 93 Q08380 OS=Homo sapiens 65.289 5.27 GN=LGALS3BP PE=1 SV=1 Gelsolin OS=Homo sapiens 94 P06396 85.644 6.28 GN=GSN PE=1 SV=1 Glutathione peroxidase 3 95 P22352 OS=Homo sapiens GN=GPX3 25.537 8.13 PE=1 SV=2 Haptoglobin OS=Homo 96 P00738 45.177 6.58 sapiens GN=HP PE=1 SV=1 Haptoglobin-related protein 97 P00739 OS=Homo sapiens GN=HPR 39.005 7.09 PE=1 SV=2 Heat shock 70 kDa protein 12B 98 Q96MM6 OS=Homo sapiens 75.64 8.53 GN=HSPA12B PE=2 SV=2 Hemoglobin subunit alpha 99 P69905 OS=Homo sapiens GN=HBA1 15.248 8.68 PE=1 SV=2 Hemoglobin subunit beta 100 P68871 OS=Homo sapiens GN=HBB 15.988 7.28 PE=1 SV=2 Hemopexin OS=Homo sapiens 101 P02790 51.643 7.02 GN=HPX PE=1 SV=2 Heparin cofactor 2 OS=Homo 102 P05546 57.034 6.9 sapiens GN=SERPIND1 PE=1
32 SV=3 Hepatocyte growth factor 103 Q04756 activator OS=Homo sapiens 70.636 7.24 GN=HGFAC PE=1 SV=1 Hepatocyte growth factor-like 104 P26927 protein OS=Homo sapiens 80.268 7.68 GN=MST1 PE=1 SV=2 Histidine-rich glycoprotein 105 P04196 OS=Homo sapiens GN=HRG 59.541 7.5 PE=1 SV=1 Hyaluronan-binding protein 2 106 Q14520 OS=Homo sapiens 62.63 6.54 GN=HABP2 PE=1 SV=1 Ig alpha-1 chain C region 107 P01876 OS=Homo sapiens 37.631 6.51 GN=IGHA1 PE=1 SV=2 Ig alpha-2 chain C region 108 P01877 OS=Homo sapiens 36.503 6.1 GN=IGHA2 PE=1 SV=3 Ig delta chain C region 109 P01880 OS=Homo sapiens GN=IGHD 42.227 7.93 PE=1 SV=2 Ig gamma-1 chain C region 110 P01857 OS=Homo sapiens 36.083 8.19 GN=IGHG1 PE=1 SV=1 Ig gamma-2 chain C region 111 P01859 OS=Homo sapiens 35.878 7.59 GN=IGHG2 PE=1 SV=2 Ig gamma-3 chain C region 112 P01860 OS=Homo sapiens 41.26 7.9 GN=IGHG3 PE=1 SV=2 Ig gamma-4 chain C region 113 P01861 OS=Homo sapiens 35.918 7.36 GN=IGHG4 PE=1 SV=1 Ig heavy chain V-I region HG3 114 P01743 12.937 8.92 OS=Homo sapiens PE=4 SV=1 Ig heavy chain V-I region Mot 115 P06326 13.571 6.29 OS=Homo sapiens PE=1 SV=1 Ig heavy chain V-I region V35 116 P23083 13 9.55 OS=Homo sapiens PE=1 SV=1 Ig heavy chain V-II region 117 P06331 ARH-77 OS=Homo sapiens 16.218 8.28 PE=4 SV=1
33 Ig heavy chain V-II region 118 P01824 WAH OS=Homo sapiens PE=1 14.108 8.46 SV=1 Ig heavy chain V-III region 119 P01766 BRO OS=Homo sapiens PE=1 13.218 6.57 SV=1 Ig heavy chain V-III region 120 P01767 BUT OS=Homo sapiens PE=1 12.371 9.25 SV=1 Ig heavy chain V-III region 121 P01768 CAM OS=Homo sapiens PE=1 13.659 9.63 SV=1 Ig heavy chain V-III region 122 P01769 GA OS=Homo sapiens PE=1 13.157 9.77 SV=1 Ig heavy chain V-III region 123 P01781 GAL OS=Homo sapiens PE=1 12.722 8.48 SV=1 Ig heavy chain V-III region 124 P80419 GAR OS=Homo sapiens PE=1 13.079 4.81 SV=1 Ig heavy chain V-III region 125 P01771 HIL OS=Homo sapiens PE=1 13.557 9.36 SV=1 Ig heavy chain V-III region 126 P01780 JON OS=Homo sapiens PE=1 12.555 9.29 SV=1 Ig heavy chain V-III region 127 P01772 KOL OS=Homo sapiens PE=1 13.709 5.87 SV=1 Ig heavy chain V-III region 128 P01765 TIL OS=Homo sapiens PE=1 12.348 9.13 SV=1 Ig heavy chain V-III region 129 P01762 TRO OS=Homo sapiens PE=1 13.464 9.72 SV=1 Ig heavy chain V-III region 130 P01779 TUR OS=Homo sapiens PE=1 12.423 9.73 SV=1 Ig heavy chain V-III region 131 P01764 VH26 OS=Homo sapiens 12.574 8.28 PE=1 SV=1 Ig heavy chain V-III region 132 P01776 13.082 7.99 WAS OS=Homo sapiens PE=1
34 SV=1 Ig heavy chain V-III region 133 P01763 WEA OS=Homo sapiens PE=1 12.249 8.5 SV=1 Ig heavy chain V-III region 134 P01778 ZAP OS=Homo sapiens PE=1 12.574 8.51 SV=1 Ig kappa chain C region 135 P01834 OS=Homo sapiens GN=IGKC 11.602 5.87 PE=1 SV=1 Ig kappa chain V-I region AG 136 P01593 11.985 5.99 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region 137 P04430 BAN OS=Homo sapiens PE=1 11.833 8.44 SV=1 Ig kappa chain V-I region CAR 138 P01596 11.696 9.41 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region DEE 139 P01597 11.654 9.36 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region EU 140 P01598 11.781 8.44 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Gal 141 P01599 11.807 8.88 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region 142 P01601 HK101 (Fragment) OS=Homo 12.791 8.16 sapiens PE=4 SV=1 Ig kappa chain V-I region HK102 (Fragment) OS=Homo 143 P01602 12.76 6.51 sapiens GN=IGKV1-5 PE=4 SV=1 Ig kappa chain V-I region Kue 144 P01604 12.119 8.81 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Lay 145 P01605 11.827 7.96 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Mev 146 P01612 11.863 6.57 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Ni 147 P01613 12.238 5.36 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Roy 148 P01608 11.775 5.36 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region Scw 149 P01609 11.757 6 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-I region 150 P04431 14.06 8.97 Walker OS=Homo sapiens
35 PE=1 SV=1 Ig kappa chain V-I region 151 P01610 WEA OS=Homo sapiens PE=1 11.833 8.91 SV=1 Ig kappa chain V-I region Wes 152 P01611 11.601 7.28 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-II region FR 153 P01615 12.652 7.94 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-II region 154 P01616 MIL OS=Homo sapiens PE=1 12.048 9.29 SV=1 Ig kappa chain V-II region 155 P06310 RPMI 6410 OS=Homo sapiens 14.697 9.25 PE=4 SV=1 Ig kappa chain V-II region 156 P01617 TEW OS=Homo sapiens PE=1 12.308 6 SV=1 Ig kappa chain V-III region B6 157 P01619 11.628 9.25 OS=Homo sapiens PE=1 SV=1 Ig kappa chain V-III region 158 P04207 CLL OS=Homo sapiens PE=1 14.266 8.51 SV=2 Ig kappa chain V-III region 159 P04206 GOL OS=Homo sapiens PE=1 11.823 9.25 SV=1 Ig kappa chain V-III region 160 P18136 HIC OS=Homo sapiens PE=2 14.08 6.6 SV=2 Ig kappa chain V-III region 161 P06311 IARC/BL41 OS=Homo 14.061 6.61 sapiens PE=1 SV=1 Ig kappa chain V-III region 162 P01621 NG9 (Fragment) OS=Homo 10.722 6.52 sapiens PE=1 SV=1 Ig kappa chain V-III region 163 P01624 POM OS=Homo sapiens PE=1 11.915 8.94 SV=1 Ig kappa chain V-III region 164 P01620 SIE OS=Homo sapiens PE=1 11.768 8.48 SV=1 Ig kappa chain V-III region 165 P04433 VG (Fragment) OS=Homo 12.567 4.96 sapiens PE=1 SV=1
36 Ig kappa chain V-III region 166 P04434 VH (Fragment) OS=Homo 12.749 5.94 sapiens PE=4 SV=1 Ig kappa chain V-IV region 167 P06314 B17 OS=Homo sapiens PE=2 14.956 6.58 SV=1 Ig kappa chain V-IV region JI 168 P06313 14.623 6.58 OS=Homo sapiens PE=4 SV=1 Ig kappa chain V-IV region 169 P01625 Len OS=Homo sapiens PE=1 12.632 7.93 SV=2 Ig lambda chain V region 4A 170 P04211 12.372 7.03 OS=Homo sapiens PE=4 SV=1 Ig lambda chain V-I region 171 P06316 BL2 OS=Homo sapiens PE=2 13.556 7.77 SV=1 Ig lambda chain V-I region HA 172 P01700 11.889 8.91 OS=Homo sapiens PE=1 SV=1 Ig lambda chain V-I region 173 P01701 NEW OS=Homo sapiens PE=1 11.446 8 SV=1 Ig lambda chain V-I region 174 P01703 NEWM OS=Homo sapiens 10.898 9.29 PE=1 SV=1 Ig lambda chain V-I region 175 P04208 WAH OS=Homo sapiens PE=1 11.718 6.54 SV=1 Ig lambda chain V-II region 176 P01710 BO OS=Homo sapiens PE=1 11.778 6 SV=1 Ig lambda chain V-II region 177 P01708 BUR OS=Homo sapiens PE=1 11.499 7.87 SV=1 Ig lambda chain V-II region 178 P01709 MGC OS=Homo sapiens PE=1 11.551 5.29 SV=1 Ig lambda chain V-II region 179 P01707 TRO OS=Homo sapiens PE=1 11.554 8.29 SV=1 Ig lambda chain V-III region 180 P80748 LOI OS=Homo sapiens PE=1 11.928 5.08 SV=1 Ig lambda chain V-III region 181 P01714 11.386 6.52 SH OS=Homo sapiens PE=1
37 SV=1 Ig lambda chain V-IV region 182 P01717 Hil OS=Homo sapiens PE=1 11.51 6.51 SV=1 Ig lambda chain V-V region 183 P01719 DEL OS=Homo sapiens PE=1 11.336 5.36 SV=1 Ig lambda chain V-VI region 184 P06319 EB4 OS=Homo sapiens PE=2 14.138 5.05 SV=1 Ig lambda chain V-VI region 185 P06317 SUT OS=Homo sapiens PE=1 12.24 5.12 SV=1 Ig lambda-2 chain C regions 186 P0CG05 OS=Homo sapiens GN=IGLC2 11.287 7.24 PE=1 SV=1 Ig mu chain C region 187 P01871 OS=Homo sapiens GN=IGHM 49.276 6.77 PE=1 SV=3 Ig mu heavy chain disease 188 P04220 protein OS=Homo sapiens 43.03 5.24 PE=1 SV=1 IgGFc-binding protein 189 Q9Y6R7 OS=Homo sapiens 571.639 5.34 GN=FCGBP PE=1 SV=3 Immunoglobulin J chain 190 P01591 OS=Homo sapiens GN=IGJ 18.087 5.24 PE=1 SV=4 Immunoglobulin lambda-like polypeptide 1 OS=Homo 191 P15814 22.949 10.07 sapiens GN=IGLL1 PE=1 SV=1 Immunoglobulin lambda-like polypeptide 5 OS=Homo 192 B9A064 23.049 8.84 sapiens GN=IGLL5 PE=2 SV=2 Insulin-like growth factor- binding protein 3 OS=Homo 193 P17936 31.654 8.69 sapiens GN=IGFBP3 PE=1 SV=2 Insulin-like growth factor- binding protein complex acid 194 P35858 65.994 6.79 labile subunit OS=Homo sapiens GN=IGFALS PE=1
38 SV=1 Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo 195 P19827 101.326 6.79 sapiens GN=ITIH1 PE=1 SV=3 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo 196 P19823 106.397 6.86 sapiens GN=ITIH2 PE=1 SV=2 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo 197 Q06033 99.787 5.74 sapiens GN=ITIH3 PE=1 SV=2 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo 198 Q14624 103.293 6.98 sapiens GN=ITIH4 PE=1 SV=4 Kallistatin OS=Homo sapiens 199 P29622 48.511 7.75 GN=SERPINA4 PE=1 SV=3 Keratin, type I cytoskeletal 10 200 P13645 OS=Homo sapiens 58.792 5.21 GN=KRT10 PE=1 SV=6 Keratin, type I cytoskeletal 13 201 P13646 OS=Homo sapiens 49.557 4.96 GN=KRT13 PE=1 SV=4 Keratin, type I cytoskeletal 16 202 P08779 OS=Homo sapiens 51.236 5.05 GN=KRT16 PE=1 SV=4 Keratin, type I cytoskeletal 9 203 P35527 OS=Homo sapiens GN=KRT9 62.027 5.24 PE=1 SV=3 Keratin, type II cytoskeletal 1 204 P04264 OS=Homo sapiens GN=KRT1 65.999 8.12 PE=1 SV=6 Keratin, type II cytoskeletal 2 205 P35908 epidermal OS=Homo sapiens 65.393 8 GN=KRT2 PE=1 SV=2 Keratin, type II cytoskeletal 5 206 P13647 OS=Homo sapiens GN=KRT5 62.34 7.74 PE=1 SV=3 Kininogen-1 OS=Homo 207 P01042 sapiens GN=KNG1 PE=1 71.912 6.81 SV=2
39 Leucine-rich alpha-2- glycoprotein OS=Homo 208 P02750 38.154 6.95 sapiens GN=LRG1 PE=1 SV=2 Lipopolysaccharide-binding 209 P18428 protein OS=Homo sapiens 53.35 6.7 GN=LBP PE=1 SV=3 Low affinity immunoglobulin gamma Fc region receptor III- 210 P08637 29.071 8.07 A OS=Homo sapiens GN=FCGR3A PE=1 SV=2 L-selectin OS=Homo sapiens 211 P14151 42.159 6.6 GN=SELL PE=1 SV=2 Lumican OS=Homo sapiens 212 P51884 38.405 6.61 GN=LUM PE=1 SV=2 Lymphatic vessel endothelial hyaluronic acid receptor 1 213 Q9Y5Y7 35.191 8.28 OS=Homo sapiens GN=LYVE1 PE=1 SV=2 Lysozyme C OS=Homo 214 P61626 16.526 9.16 sapiens GN=LYZ PE=1 SV=1 Mannan-binding lectin serine 215 P48740 protease 1 OS=Homo sapiens 79.195 5.49 GN=MASP1 PE=1 SV=3 Matrix-remodeling-associated 216 Q9NR99 protein 5 OS=Homo sapiens 311.955 8.32 GN=MXRA5 PE=2 SV=3 Monocyte differentiation 217 P08571 antigen CD14 OS=Homo 40.051 6.23 sapiens GN=CD14 PE=1 SV=2 N-acetylmuramoyl-L-alanine 218 Q96PD5 amidase OS=Homo sapiens 62.178 7.55 GN=PGLYRP2 PE=1 SV=1 Neural cell adhesion molecule 219 P32004 L1 OS=Homo sapiens 139.915 6.24 GN=L1CAM PE=1 SV=2 Neurofibromin OS=Homo 220 P21359 319.168 7.39 sapiens GN=NF1 PE=1 SV=2 Phosphatidylcholine-sterol acyltransferase OS=Homo 221 P04180 49.546 6.11 sapiens GN=LCAT PE=1 SV=1 Phosphatidylinositol-glycan- 222 P80108 92.278 6.37 specific phospholipase D
40 OS=Homo sapiens GN=GPLD1 PE=1 SV=3 Phospholipid transfer protein 223 P55058 OS=Homo sapiens GN=PLTP 54.705 7.01 PE=1 SV=1 Pigment epithelium-derived 224 P36955 factor OS=Homo sapiens 46.283 6.38 GN=SERPINF1 PE=1 SV=4 Plasma kallikrein OS=Homo 225 P03952 sapiens GN=KLKB1 PE=1 71.323 8.22 SV=1 Plasma protease C1 inhibitor 226 P05155 OS=Homo sapiens 55.119 6.55 GN=SERPING1 PE=1 SV=2 Plasma serine protease 227 P05154 inhibitor OS=Homo sapiens 45.646 9.26 GN=SERPINA5 PE=1 SV=3 Plasminogen OS=Homo 228 P00747 90.51 7.24 sapiens GN=PLG PE=1 SV=2 Plastin-2 OS=Homo sapiens 229 P13796 70.244 5.43 GN=LCP1 PE=1 SV=6 Platelet basic protein 230 P02775 OS=Homo sapiens GN=PPBP 13.885 8.79 PE=1 SV=3 Platelet factor 4 variant 231 P10720 OS=Homo sapiens GN=PF4V1 11.545 9.1 PE=1 SV=1 Polypeptide N- acetylgalactosaminyltransferas 232 Q86SR1 68.948 8.59 e 10 OS=Homo sapiens GN=GALNT10 PE=1 SV=2 Prenylcysteine oxidase 1 233 Q9UHG3 OS=Homo sapiens 56.604 6.18 GN=PCYOX1 PE=1 SV=3 Properdin OS=Homo sapiens 234 P27918 51.242 7.9 GN=CFP PE=1 SV=2 Protein AMBP OS=Homo 235 P02760 sapiens GN=AMBP PE=1 38.974 6.25 SV=1 Protein Z-dependent protease 236 Q9UK55 inhibitor OS=Homo sapiens 50.674 8.27 GN=SERPINA10 PE=1 SV=1 Proteoglycan 4 OS=Homo 237 Q92954 150.984 9.5 sapiens GN=PRG4 PE=1
41 SV=2 Prothrombin OS=Homo 238 P00734 69.992 5.9 sapiens GN=F2 PE=1 SV=2 Putative V-set and immunoglobulin domain- containing-like protein 239 A6NJ16 13.576 9.6 IGHV4OR15-8 OS=Homo sapiens GN=IGHV4OR15-8 PE=5 SV=2 Retinol-binding protein 4 240 P02753 OS=Homo sapiens GN=RBP4 22.995 6.07 PE=1 SV=3 Selenoprotein P OS=Homo 241 P49908 sapiens GN=SEPP1 PE=1 43.156 7.87 SV=3 Serotransferrin OS=Homo 242 P02787 77.014 7.12 sapiens GN=TF PE=1 SV=3 Serum albumin OS=Homo 243 P02768 69.321 6.28 sapiens GN=ALB PE=1 SV=2 Serum amyloid A-1 protein 244 P0DJI8 OS=Homo sapiens GN=SAA1 13.524 6.79 PE=1 SV=1 Serum amyloid A-4 protein 245 P35542 OS=Homo sapiens GN=SAA4 14.737 9.07 PE=1 SV=2 Serum amyloid P-component 246 P02743 OS=Homo sapiens GN=APCS 25.371 6.54 PE=1 SV=2 Serum paraoxonase/arylesterase 1 247 P27169 39.706 5.22 OS=Homo sapiens GN=PON1 PE=1 SV=3 Sex hormone-binding globulin 248 P04278 OS=Homo sapiens GN=SHBG 43.752 6.71 PE=1 SV=2 Sulfhydryl oxidase 1 249 O00391 OS=Homo sapiens 82.526 8.92 GN=QSOX1 PE=1 SV=3 TBC1 domain family member 250 Q9BYX2 2A OS=Homo sapiens 105.348 6.58 GN=TBC1D2 PE=1 SV=3 Tetranectin OS=Homo sapiens 251 P05452 22.522 5.67 GN=CLEC3B PE=1 SV=3
42 Thrombospondin-1 OS=Homo 252 P07996 sapiens GN=THBS1 PE=1 129.3 4.94 SV=2 Thyroxine-binding globulin 253 P05543 OS=Homo sapiens 46.295 6.3 GN=SERPINA7 PE=1 SV=2 Transforming growth factor- beta-induced protein ig-h3 254 Q15582 74.634 7.71 OS=Homo sapiens GN=TGFBI PE=1 SV=1 Transmembrane protein 198 255 Q66K66 OS=Homo sapiens 39.449 9.92 GN=TMEM198 PE=1 SV=1 Transthyretin OS=Homo 256 P02766 15.877 5.76 sapiens GN=TTR PE=1 SV=1 Tubulin polyglutamylase 257 Q6ZT98 TTLL7 OS=Homo sapiens 102.934 9.29 GN=TTLL7 PE=2 SV=2 Vitamin D-binding protein 258 P02774 OS=Homo sapiens GN=GC 52.929 5.54 PE=1 SV=1 Vitamin K-dependent protein 259 P04070 C OS=Homo sapiens 52.037 6.28 GN=PROC PE=1 SV=1 Vitamin K-dependent protein S 260 P07225 OS=Homo sapiens 75.074 5.67 GN=PROS1 PE=1 SV=1 Vitamin K-dependent protein Z 261 P22891 OS=Homo sapiens GN=PROZ 44.715 5.97 PE=1 SV=2 Vitronectin OS=Homo sapiens 262 P04004 54.271 5.8 GN=VTN PE=1 SV=1 von Willebrand factor 263 P04275 OS=Homo sapiens GN=VWF 309.058 5.48 PE=1 SV=4 Xaa-Pro dipeptidase 264 P12955 OS=Homo sapiens GN=PEPD 54.513 6 PE=1 SV=3 Zinc-alpha-2-glycoprotein 265 P25311 OS=Homo sapiens 34.237 6.05 GN=AZGP1 PE=1 SV=2
43 44