Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines. K. IGARASHI, K. KAWAGUCHI, T. KIYUNA, T. MURAKAMI, S. MIWA, S.D. NELSON, S.M. DRY, Y. LI, A.S. SINGH, H. KIMURA, K. HAYASHI, N. YAMAMOTO, H. TSUCHIYA, F.C. EILBER, R.M. HOFFMAN (San Diego; Los Angeles, CA, USA; Kanazawa, Japan) ...... 4081

WNT/ β- Catenin Signaling Inhibitor IC-2 Suppresses Sphere Formation and Sensitizes Colorectal Cancer Cells to 5-Fluorouracil. S. URUSHIBARA, T. TSUBOTA, R. ASAI, J. AZUMI, K. ASHIDA, Y. FUJIWARA, G. SHIOTA (Yonago, Japan) ...... 4085

Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models. A. KONAGAI, K. YOSHIMURA, S. HAZAMA, N. YAMAMOTO, K. AOKI, T. UENO, M. FUJIOKA, H. IIJIMA, M. KATO, M. UCHIDA, T. WADA, M. INOUE, T. ASAO, M. FUSE, S. WADA, A. KURAMASU, R. KAMEI, S. TAKEDA, S. YAMAMOTO, S. YOSHINO, M. OKA, H. NAGANO (Yamaguchi; Tokyo; Ube; Kurashiki; Yokohama, Japan) ...... 4093

Cell Cycle Arrest and Apoptosis Induced by Kinamycin F in Human Osteosarcoma Cells. A. BAVELLONI, E. FOCACCIA, M. PIAZZI, C. ERRANI, W. BLALOCK, I. FAENZA (Bologna, Italy) ...... 4103

Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells. Y. NINOMIYA, D. YU, E. SEKINE-SUZUKI, T. NAKAJIMA (Chiba, Japan; Soochow, PR China) ...... 4111

Differences in Extracellular Matrix Composition and its Role in Invasion in Primary and Secondary Intracerebral Malignancies. J. VIRGA, C.D. SZEMCSÁK, J. REMÉNYI-PUSKÁR, J. TÓTH, T. HORTOBÁGYI, É. CSŐSZ, G. ZAHUCZKY, L. SZIVOS, L. BOGNÁR, A. KLEKNER (Debrecen, Hungary) ...... 4119

Z-360 Suppresses Tumor Growth in MIA PaCa-2-bearing Mice via Inhibition of Gastrin-induced Anti- Apoptotic Effects. Y. SHIOMI, M. YOSHIMURA, K. KUKI, Y. HORI, T. TANAKA (Kumagaya, Japan) .... 4127

Highly Eribulin-resistant KBV20C Oral Cancer Cells Can Be Sensitized by Co-treatment with the Third- generation P-Glycoprotein Inhibitor, Elacridar, at a Low Dose. Y. PARK, J.-Y. SON, B.-M. LEE, H.S. KIM, S. YOON (Suwon, Republic of Korea) ...... 4139 Clinical Studies

Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma. H. HONJO, Y. TOH, M. SOHDA, S. SUZUKI, K. KAIRA, Y. KANAI, S. NAGAMORI, T. OYAMA, T. YOKOBORI, T. MIYAZAKI, H. KUWANO (Gunma; Fukuoka; Osaka, Japan) ...... 4147

Long-term Oncologic Outcomes of Robotic-assisted Radical Prostatectomy by a Single Surgeon. S.-C. HUNG, C.-K. YANG, C.-L. CHENG, Y.-C. OU (Taichung, Taiwan, ROC) ...... 4157 Contents continued on the preceding page Contents continued

+ + The Prognostic Significance of the Tumor-infiltrating Programmed Cell Death-1 to CD8 Lymphocyte Ratio in Patients with Colorectal Cancer. M. SHIBUTANI, K. MAEDA, H. NAGAHARA, T. FUKUOKA, S. NAKAO, S. MATSUTANI, K. HIRAKAWA, M. OHIRA (Osaka, Japan) ...... 4165

Anastrozole-induced Autoimmune Hepatitis: A Rare Complication of Breast Cancer Therapy. O. KLAPKO, E. GHOULAM, S. JAKATE, S. ESWARAN, L. USHA (Chicago, IL, USA) ...... 4173

Cerebrospinal Fluid Penetration Rate and Efficacy of Afatinib in Patients with EGFR Mutation-positive Non- small Cell Lung Cancer with Leptomeningeal Carcinomatosis: A Multicenter Prospective Study. A. TAMIYA, M. TAMIYA, T. NISHIHARA, T. SHIROYAMA, K. NAKAO, T. TSUJI, N. TAKEUCHI, S.-I. ISA, N. OMACHI, N. OKAMOTO, H. SUZUKI, K. OKISHIO, A. IWAZAKI, K. IMAI, T. HIRASHIMA, S. ATAGI (Sakai; Habikino; Hirakata, Japan) ...... 4177

Vaginal and Urine Self-sampling Compared to Cervical Sampling for HPV-testing with the Cobas 4800 HPV Test. K.C. ASCIUTTO, A.J. HENNINGSSON, H. BORGFELDT, L. DARLIN, C. BORGFELDT (Lund; Jönköping, Sweden) ...... 4183

Metabolic Rather than Pathological Response to Preoperative Chemoradiotherapy Is a Stronger Predictor of Survival in cStage IIB-IV Esophageal Cancer. S. MOTOYAMA, Y. SATO, K. MARUYAMA, S. USAMI, K. YOSHINO, T. NAKATSU, T. SASAKI, A. WAKITA, Y. KAWAKITA, J. LIU, A. ANBAI, K. ISHIYAMA, H. SAITO, Y. MINAMIYA (Akita, Japan) ...... 4189

Safety and Effectiveness of Laparoscopic Colorectal Resection in Elderly Patients with Colorectal Cancer: Α Propensity Score Matching Study. A. ARIMOTO, H. HASEGAWA, H. SUGIYAMA, K. YAMASHITA, T. MATSUDA, M. TOMINAGA, Y. SUMI, S. SUZUKI, Y. KAKEJI (Kobe; Akashi, Japan) ...... 4195

Early Gastric Cancer Exfoliating into Gastric Lavage (GL1 EGC) Shows a More Aggressive Behavior and Poorer Survival Compared to the Non-Exfoliative Counterpart (GL0 EGC). E. VIRGILIO, E. GIARNIERI, M.R. GIOVAGNOLI, M. MONTAGNINI, A. PROIETTI, R. D’URSO, P. MERCANTINI, G. BALDUCCI, M. CAVALLINI (Rome, Italy) ...... 4199

Venous Resection in Pancreatic Ductal Adenocarcinoma: Impact of Surgical Experience on Early Postoperative Courses. T. GUILBAUD, O. TURRINI, C. LEMOINE, Y.P. LE TREUT, M. OUAISSI, V. MOUTARDIER, J.R. DELPERO (Marseille, France) ...... 4205

Utility of Inflammatory Marker- and Nutritional Status-based Prognostic Factors for Predicting the Prognosis of Stage IV Gastric Cancer Patients Undergoing Non-curative Surgery. K. MIMATSU, N. FUKINO, Y. OGASAWARA, Y. SAINO, T. OIDA (Kanagawa, Tokyo, Japan) ...... 4215

Discrepancy in Programmed Cell Death-Ligand 1 Between Primary and Metastatic Non-small Cell Lung Cancer. S. TAKAMORI, G. TOYOKAWA, I. OKAMOTO, K. TAKADA, Y. KOZUMA, T. MATSUBARA, N. HARATAKE, T. AKAMINE, M. KATSURA, N. MUKAE, F. SHOJI, T. OKAMOTO, Y. ODA, T. IWAKI, K. IIHARA, Y. NAKANISHI, Y. MAEHARA (Fukuoka, Japan) ...... 4223

Adrenal Insufficiency Related to Anti-Programmed Death-1 Therapy. R. ARIYASU, A. HORIIKE, T. YOSHIZAWA, Y. DOTSU, J. KOYAMA, M. SAIKI, T. SONODA, S. NISHIKAWA, S. KITAZONO, N. YANAGITANI, M. NISHIO (Tokyo, Japan) ...... 4229

Total Glossectomy Without Laryngectomy for Advanced Squamous Cell Cancer of the Tongue: Functional and Oncological Results. M. REITER, U. HARRÉUS (Munich; Dusseldorf, Germany) ...... 4233

Feasibility of Postoperative Radiotherapy Using Conventional Fractionation for Lymph Node Metastasis from Cutaneous Melanoma. Y.J. KIM, S.Y. SONG, W. KIM, S.-Y. JEONG, W. CHOI, H.U. JE, J.-S. LEE, E.K. CHOI (Seoul; Gangneung; Ulsan, Republic of Korea) ...... 4239 Contents continued on the preceding page Contents continued

PROCEEDINGS OF THE CHINA-UNITED KINGDOM CANCER (CUKC) CONFERENCE, BEIJING, CHINA, 2017 ...... 4247

Experimental Studies Clinical Significance of PD1 and PDL1 in Human Breast Cancer. M. UHERCIK, A.J. SANDERS, S. OWEN, E.L. DAVIES, A.K. SHARMA, W.G. JIANG, K. MOKBEL (Cardiff; London, UK) ...... 4249

Potential Implication of Paxillin in Cancer Establishment Within the Bone Environment. A.D. SOBKOWICZ, A.J. SANDERS, M.D. MASON, W.G. JIANG (Cardiff, UK) ...... 4255

Protein of Vascular Endothelial Growth Inhibitor 174 Inhibits Epithelial–Mesenchymal Transition in Renal Cell Carcinoma In Vivo . Q. ZHAO, X. DENG, B. HONG, F. WANG, X. TANG, Y. YANG, K. GONG, L. YE, W.G. JIANG, N. ZHANG (Beijing; Xinjiang, PR China; Cardiff, UK) ...... 4269

Expression of Osteoprotegrin Is Enhanced in Lung Cancer Tissues and Promotes Aggressive Cellular Traits in H3122 Lung Cancer Cells. Z. YU, A.J. SANDERS, S. OWEN, S. CHENG, X. YANG, W.G. JIANG (Beijing, PR China; Cardiff, UK) ...... 4277

Inhibition of Bevacizumab-induced Epithelial–Mesenchymal Transition by BATF2 Overexpression Involves the Suppression of Wnt/ β- Catenin Signaling in Glioblastoma Cells. W. HUANG, C. ZHANG, M. CUI, J. NIU, W. DING (Beijing, PR China) ...... 4285

A Preclinical Study of Cell-seeded Tubularized Scaffolds Specially Secreting LL37 for Reconstruction of Long Urethral Defects. Y. LI, J. WU, F. FENG, C. MEN, D. YANG, Z. GAO, Z. ZHU, Y. CUI, H. ZHAO (Yantai, PR China; Cleveland, OH, USA) ...... 4295

GRP78 Participates in PCA3-regulated Prostate Cancer Progression. C. LIN, J. WANG, Y. WANG, P. ZHU, X. LIU, N. LI, J. LIU, L. YU, W. WANG (Yantai, PR China) ...... 4303

Immortalized Cancer-associated Fibroblasts Promote Prostate Cancer Carcinogenesis, Proliferation and Invasion. S. YU, Y. JIANG, F. WAN, J. WU, Z. GAO, D. LIU (Yantai, PR China) ...... 4311

Therapeutic Role of MiR-140-5p for the Treatment of Non-small Cell Lung Cancer. V. FLAMINI, W.G. JIANG, Y. CUI (Cardiff, UK) ...... 4319

High-efficient Screening Method for Identification of Key Genes in Breast Cancer Through Microarray and Bioinformatics. Z. LIU, G. LIANG, L. TAN, A. SU, W. JIANG, C. GONG (Guangzhou, PR China; Cardiff, UK) ... 4329

HIF1 α- associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. G. LIANG, Z. LIU, L. TAN, A. SU, W.G. JIANG, C. GONG (Guangzhou, PR China; Cardiff, UK) ...... 4337 miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. Z.H. LONG, Z.G. BAI, J.N. SONG, Z. ZHENG, J. LI, J. ZHANG, J. CAI, H.W. YAO, J. WANG, Y.C. YANG, J. YIN, Z.T. ZHANG (Beijing, PR China) ...... 4345

Ezrin-Radixin-Moesin Binding Phosphoprotein 50 (EBP50) Suppresses the Metastasis of Breast Cancer and HeLa Cells by Inhibiting Matrix Metalloproteinase-2 Activity. L. WANG, Y. QI, Y. XIONG, Z. PENG, Q. MA, Y. ZHANG, J. SONG, J. ZHENG (Beijing, PR China) ...... 4353

The Axis of CXCR4/SDF-1 Plays a Role in Colon Cancer Cell Adhesion Through Regulation of the AKT and IGF1R Signalling Pathways. F. ZHENG, Z. ZHANG, V. FLAMINI, W.G. JIANG, Y. CUI (Cardiff, UK; Beijing, PR China) ...... 4361

Comparison of Different Muscle-Relaxant Anesthetics on Growth, Migration and Invasion of Gastric Cancer Cells. A. JIANG, H. ZHAO, X. LIU, M. YU, J. CHEN, W.G. JIANG (Yantai, PR China; Cardiff, UK) ...... 4371 Contents continued on the preceding page Contents continued

Identification of Novel Proteins Interacting with Vascular Endothelial Growth Inhibitor 174 in Renal Cell Carcinoma. Q. ZHAO, D. KUN, B. HONG, X. DENG, S. GUO, X. TANG, Y. YANG, K. GONG, Q. LI, L. YE, W.G. JIANG, N. ZHANG (Beijing; Hami; Kelamayi; Taicang; Guangzhou, PR China; Cardiff, UK) ...... 4379

Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro . Z. ZHAO, S. CHENG, C. ZABKIEWICZ, J. CHEN, L. ZHANG, L. YE, W.G. JIANG (Beijing, PR China; Cardiff, UK) ...... 4389

Analysis of Association Between MGMT and p53 Gene Single Nucleotide Polymorphisms and Laryngeal Cancer. Y. LV, C. JIA, A. JIANG, H. ZHANG, Y. WANG, F. LIU, L. YANG, Y. SUN, R. LV, X. SONG (Yantai, PR China) ...... 4399

NHERF1 Suppresses Lung Cancer Cell Migration by Regulation of Epithelial–Mesenchymal Transition. F. YANG, Y. GU, Z. ZHAO, J. HUANG, W.G. JIANG, S. CHENG (Beijing, PR China; Cardiff, UK) ...... 4405

Knockdown of EPHA1 Using CRISPR/CAS9 Suppresses Aggressive Properties of Ovarian Cancer Cells. Y. CUI, B. WU, V. FLAMINI, B.A.J. EVANS, D. ZHOU, W.G. JIANG (Cardiff, UK; Beijing, PR China) ...... 4415

Puerarin Induces Hepatocellular Carcinoma Cell Apoptosis Modulated by MAPK Signaling Pathways in a Dose-dependent Manner. W.-G. ZHANG, X.-C. YIN, X.-F. LIU, K.-W. MENG, K. TANG, F.-L. HUANG, G. XU, J. GAO (Yantai; Weihai, PR China) ...... 4425

Synergistic Effects of SAM and Selenium Compounds on Proliferation, Migration and Adhesion of HeLa Cells. L. SUN, J. ZHANG, Q. YANG, Y. SI, Y. LIU, Q. WANG, F. HAN, Z. HUANG (Beijing, PR China) ...... 4433

Cyclophilin A Is Overexpressed in Hepatocellular Carcinoma and Is Associated with the Cell Cycle. Z. GONG, C. CHI, X. HUANG, H. CHU, J. WANG, F. DU, L. JIANG, J. CHEN (Yantai; Weihai, PR China) ...... 4443

Transcriptional Profiling of Sonic Hedgehog in a Prospective Cohort of Breast Cancer in a Pakistani Population. S.K. RIAZ, L. YE, N.E. SAHAR, D. AMAN, J. QADIR, J.S. KHAN, M. SAEED, W.G. JIANG, M.F.A. MALIK (Islamabad; Rawalpindi, Pakistan; Cardiff, UK) ...... 4449

Global Analysis of miRNA–mRNA Interaction Network in Breast Cancer with Brain Metastasis. Z. LI, Z. PENG, S. GU, J. ZHENG, D. FENG, Q. QIN, J. HE (Beijing; Taiyuan, PR China) ...... 4455

Clinical Correlation Between WISP2 and β- Catenin in Gastric Cancer. L. LI, Y. CUI, J.F. JI, W.G. JIANG (Beijing, PR China; Cardiff, UK) ...... 4469

Expression and Significance of Cyclophilin J in Primary Gastric Adenocarcinoma. Z. GONG, Y. MU, J. CHEN, H. CHU, P. LIAN, C. WANG, J. WANG, L. JIANG (Yantai, PR China) ...... 4475

Role of Plexin B1 in a Breast Cancer Cohort of Pakistani Patients and its Contribution Towards Cancer Metastasis as Indicated by an In Vitro Model. M.F.A. MALIK, S.K. RIAZ, S.H. WAQAR, F. HAQ, L. YE, W.G. JIANG (Cardiff, UK; Islamabad, Pakistan) ...... 4483

Overexpression of EPHB4 Is Associated with Poor Survival of Patients with Gastric Cancer. J. YIN, Y. CUI, L. LI, J. JI, W.G. JIANG (Cardiff, UK; Beijing, PR China) ...... 4489

Reduced Expression of Metastasis Suppressor-1 (MTSS1) Accelerates Progression of Human Bladder Uroepithelium Cell Carcinoma. P. DU, S. WANG, X. TANG, C. AN, Y. YANG, W.G. JIANG (Beijing, PR China; Cardiff, UK) ...... 4499

Association of Intron Microsatellite Instability and Exon Mutational Profile of TP53 in Human Gastric Cancers. X. HUO, X. XIAO, S. ZHANG, D. ZHOU, Z. CHEN (Beijing, PR China) ...... 4507

Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis. F. WANG, J. LU, S. LI, X. HUO, X. LIU, X. DU, C. LI, J. WANG, Z. CHEN (Beijing, PR China) ...... 4515 Contents continued on the preceding page Contents continued

Clinical Studies Application of Localization and Needle Placement Guided by Mammographic, Ultrasound and Fiberoptic Ductoscopy for Resection of Non-palpable Breast Lesions. Z. YUAN, X. QU, Z.-T. ZHANG, W.G. JIANG (Beijing, PR China; Cardiff, UK) ...... 4523

Analysis of Clinicopathological Features and Prognostic Factors in 39 Cases of Bladder Neuroendocrine Carcinoma. H.-H. ZHOU, L.-Y. LIU, G.-H. YU, G.-M. QU, P.-Y. GONG, X. YU, P. YANG (Yantai; Jinan, PR China) ...... 4529

Impact of a 21-Gene Recurrence Score Test on the Choice of Adjuvant Chemotherapy for Hormone Receptor- positive Earlystage Breast Cancer: A Prospective Study. Y. ZENG, Q. LI, T. QIN, S. LI, L. JIN, J. WU, K. CHEN, H. DENG, N. RAO, Q. LIU, F. SU, W. JIA, H. YAO (Guangzhou, PR China) ...... 4539

The Clinicopathological Factors Associated with Disease Progression in Luminal A Breast Cancer and Characteristics of Metastasis: A Retrospective Study from A Single Center in China. J. YE, W. WANG, L. XIN, S. OWEN, L. XU, X. DUAN, Y. CHENG, H. ZHANG, S. ZHANG, T. LI, Y. LIU (Beijing; Datong, PR China; Cardiff, UK) ...... 4549

Severe Cardiotoxicity in a Patient with Colorectal Cancer Treated with Bevacizumab. J. CHEN, F. DU, B. HU, C. CHI, H. CHU, L. JIANG, P. LI, Z. GONG (Yantai; Dalian, PR China) ...... 4557

Application of Ultrasound-guided Core Needle Biopsy in the Diagnosis of T3 or T4 Stage Laryngeal and Hypopharyngeal Cancer. Y. WANG, D. LI, R. LIU, C. JIA, A. JIANG, Y. LV, S. XU, H. ZHANG, X. CAO, X. SONG (Yantai, PR China) ...... 4563

Collision of Lymphoepithelioma-like Carcinoma with Diffuse Large B-cell Lymphoma of the Stomach: A Case Report. L.Y. LIU, H. ZHAO, L. SHENG, P. YANG, H. ZHOU, R. WANG (Jinan, Yantai, PR China) ...... 4569

Nomogram Model of LNR Predicts Survival in Premenopausal Patients with Node-positive Luminal Breast Cancer. T. QIN, Y.-D. ZENG, Q. LU, X. ZHANG, G. QIN, Q. ZHENG, F. XU, R. PENG, Z. YUAN, S. WANG (Guangzhou, PR China) ...... 4575

Better Clinical Efficiency of TILs for Malignant Pleural Effusion and Ascites than Cisplatin Through Intrapleural and Intraperitoneal Infusion. H. CHU, F. DU, Z. GONG, P. LIAN, Z. WANG, P. LI, B. HU, C. CHI, J. CHEN (Yantai; Dalian, PR China) ...... 4587

Multifocal and Multicentric Breast Carcinoma: A Significantly More Aggressive Tumor than Unifocal Breast Cancer. Z. LANG, Y. WU, C. LI, X. LI, X. WANG, G. QU (Yantai, PR China) ...... 4593

Laparoscopic-assisted Transanal Total Mesorectal Excision for Middle–Low Rectal Carcinoma: A Clinical Study of 19 Cases. H.-W. YAO, G.-C. WU, Y.-C. YANG, L. JIN, Z.-P. ZHANG, N. CHEN, Z.-T. ZHANG (Beijing, PR China) ...... 4599

Explored Risk Factors for Lymph Node Metastasis with Siewert II/III Adenocarcinoma of the Gastroesophageal Junction. Z. ZHENG, J. YIN, H.-W. WU, J. LI, J. CAI, S.-Q. QIN, J. ZHANG, H.-W. YAO, J.-S. LI, Z.-T. ZHANG (Beijing, PR China) ...... 4605

Cyclosporin A Reversed Chemoresistance of a Patient with Pure Red Cell Aplasia Secondary to Thymoma. P. LI, F. DU, Z. GONG, B. HU, C. CHI, H. CHU, J. CHEN (Yantai; Dalian, PR China) ...... 4611

The Prognostic Value of the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging System in HER2-Enriched Subtype Breast Cancer, a Retrospective Analysis. B. ZHOU, L. XU, J. YE, L. XIN, X. DUAN, Y. LIU (Beijing, PR China; Cardiff, UK) ...... 4615

Comparison of Efficiency of Video Endoscopy and Open Inguinal Lymph Node Dissection. S. WANG, P. DU, X. TANG, C. AN, N. ZHANG, Y. YANG (Beijing, PR China) ...... 4623

Contents continued on the preceding page Contents continued

Exploration of the Radiotherapeutic Clinical Target Volume Delineation for Gastric Cancer from Lymph Node Metastases. W. DONG, B. LI, J. WANG, Y. SONG, Z. ZHANG, C. FU (Jinan; Yantai, PR China) ...... 4629

MR-guided Percutaneous Biopsy of Focal Hepatic Dome Lesions with Free-hand Combined with MR Fluoroscopy Using 1.0-T Open High-field Scanner. L. WANG, M. LIU, L. LIU, Y. ZHENG, Y. XU, X. HE, P. LI, C. LI (Jinan; Yantai; Liaocheng, PR China) ...... 4635

Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma. Y. WANG, G. XU, J. WANG, X.-H. LI, P. SUN, W. ZHANG, J.-X. LI, C.-Y. WU (Zhenjiang; Yantai, PR China) ...... 4643 125 Clinical Study on Using I Seeds Articles Combined with Biliary Stent Implantation in the Treatment of Malignant Obstructive Jaundice. T. WANG, S. LIU, Y.-B. ZHENG, X.-P. SONG, B.-L. SUN, W.-J. JIANG, L.-G. WANG (Yantai, PR China) ...... 4649

Predictors of Malignancy for Female Patients with Suspicious Nipple Discharge: A Retrospective Study. L. JIN, L. ZHU, S. LI, Y. ZENG, L. HAIXIONG, F. SU, K. CHEN (Guangzhou, PR China) ...... 4655

Preoperative High Neutrophil–to–Lymphocyte Ratio Is Associated with High-grade Bladder Cancer. X. TANG, S. WANG, C. AN, P. DU, Y. YANG (Beijing, PR China) ...... 4659

Effects of Different Palliative Jaundice Reducing Methods on Immunologic Functions in Patients with Advanced Malignant Obstructive Jaundice. K. TANG, L.-L. SUI, G. XU, T. ZHANG, Q. LIU, X.-F. LIU (Yantai, PR China) ...... 4665

Gastric Cancer Mortality Trends in China (2006-2013) Reveal Increasing Mortality in Young Subjects. J. YIN, J.-N. SONG, Z.-G. BAI, J. CAI, J. ZHANG, Z. ZHENG, H.-W. WU, P.-P. YE, X. GAO, Z.-T. ZHANG (Beijing, PR China) ...... 4671

Clinical Characteristics and Prognosis of Elderly Small Cell Lung Cancer Patients Complicated with Hyponatremia: A Retrospective Analysis. Y. YANG, N. SUN, P. SUN, L. ZHANG (Yantai, PR China) ...... 4681

Efficacy and Safety of Nab-Paclitaxel as Second-line Chemotherapy for Locally Advanced and Metastatic Non- small Cell Lung Cancer. W. WONG, P. SUN, Z. MU, J. LIU, C. YU, A. LIU (Jinan; Yantai, PR China) ...... 4687

Independent Correlation Between Ki67 Index and Circulating Tumor Cells in the Diagnosis of Colorectal Cancer. Y. YANG, J. LI, L. JIN, D. WANG, J. ZHANG, J. WANG, X. ZHAO, G. WU, H. YAO, Z. ZHANG (Beijing, PR China) ...... 4693

Study of Preoperative Antiviral Treatment of Patients with HCC Negative for HBV-DNA. X.-F. LIU, T. ZHANG, K. TANG, L.-L. SUI, G. XU, Q. LIU (Yantai, PR China) ...... 4701

Effect of Interventional Therapy on the Expression of Survivin mRNA in Cervical Cancer. S.-G. WANG, N. MU, H.-Y. SUN (Yantai; Qingdao, PR China) ...... 4707

Phase II Study of the Efficacy and Safety of High-dose Pemetrexed in Combination with Cisplatin Versus Temozolomide for the Treatment of Non-small Cell Lung Cancer with Brain Metastases. Q. HE, X. BI, C. REN, Y. WANG, P. ZOU, H. ZHANG, N. CHI, C. XIU, Y. WANG, R. TAO (Yantai; Jinan, PR China) ...... 4711