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ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005 Volume 37, Number 8, August 2017 Contents Reviews BDNF: An Oncogene or Tumor Suppressor? D.P. RADIN, P. PATEL (Stony Brook; New York City, NY, USA) ........ 3983 Vitamin D Receptor Polymorphism and Cancer: An Update. V. RAI, J. ABDO, S. AGRAWAL, D.K. AGRAWAL (Omaha, NE, USA) ............................................................................................................................. 3991 Lower Body Lymphedema in Patients with Gynecologic Cancer. N. BIGLIA, V. ZANFAGNIN, A. DANIELE, E. ROBBA, V.E. BOUNOUS (Turin, Italy) ....................................................................................... 4005 Genotoxicity Induced by Dental Materials: A Comprehensive Review. D.A. RIBEIRO, V.Q. YUJRA, C.F.G. DE MOURA, B.A. HANDAN, M.D.B. VIANA, L.Y. YAMAUCHI, P.M. CASTELO, O. AGUIAR JR (Sao Paolo, Brazil) .......................................................................................................................................................... 4017 Impact of Parental Cancer on Children. B.K. SHAH, J. ARMALY, E. SWIETER (Sedro-Woolley; Yakima, WA, USA) ................................................................................................................................................................. 4025 Experimental Studies High αv Integrin Level of Cancer Cells Is Associated with Development of Brain Metastasis in Athymic Rats. Y.J. WU, M.A. PAGEL, L.L. MULDOON, R. FU, E.A. NEUWELT (Portland, OR, USA) .................... 4029 Chemoprevention by Quercetin of Oral Squamous Cell Carcinoma by Suppression of the NF-ĸB Signaling Pathway in DMBA-treated Hamsters. W. ZHANG, G. YIN, J. DAI, Y. SUN, R.M. HOFFMAN, Z. YANG, Y. FAN (Nanjing, PR China; San Diego, CA, USA) ............................................................................................ 4041 Contents continued on the back cover Contents continued Rational Design of a Potent Pan-Pim Kinases Inhibitor with a Rhodanine–Benzoimidazole Structure. Y. SAWAGUCHI, R. YAMAZAKI, Y. NISHIYAMA, T. SASAI, M. MAE, A. ABE, T. YAEGASHI, H. NISHIYAMA, T. MATSUZAKI (Tokyo, Japan) ................................................................................................... 4051 Cyclooxygenase-2 Inhibition Enhances Proliferation of NKT Cells Derived from Patients with Laryngeal Cancer. J. KLATKA, E. GRYWALSKA, A. HYMOS, M. GUZ, K. POLBERG, J. ROLIŃSKI, A. STEPULAK (Lublin, Poland) ................................................................................................................................ 4059 LXR Activation Down-regulates Lipid Raft Markers FLOT2 and DHHC5 in MCF-7 Breast Cancer Cells. D. CARBONNELLE, T.H. LUU, C. CHAILLOU, J.-M. HUVELIN, J.-M. BARD, H. NAZIH (Nantes; St Herblain, France) .................................................................................................................................................... 4067 Nicotine Exposure Augments Renal Toxicity of 5-azacytidine Through p66shc: Prevention by Resveratrol. I. ARANY, S. HALL, A. FAISAL, M. DIXIT (Jackson, MS, USA; Lahore, Pakistan) ..................................... 4075 Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines. K. IGARASHI, K. KAWAGUCHI, T. KIYUNA, T. MURAKAMI, S. MIWA, S.D. NELSON, S.M. DRY, Y. LI, A.S. SINGH, H. KIMURA, K. HAYASHI, N. YAMAMOTO, H. TSUCHIYA, F.C. EILBER, R.M. HOFFMAN (San Diego; Los Angeles, CA, USA; Kanazawa, Japan) ......... 4081 WNT/ β- Catenin Signaling Inhibitor IC-2 Suppresses Sphere Formation and Sensitizes Colorectal Cancer Cells to 5-Fluorouracil. S. URUSHIBARA, T. TSUBOTA, R. ASAI, J. AZUMI, K. ASHIDA, Y. FUJIWARA, G. SHIOTA (Yonago, Japan) .................................................................................................................................. 4085 Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models. A. KONAGAI, K. YOSHIMURA, S. HAZAMA, N. YAMAMOTO, K. AOKI, T. UENO, M. FUJIOKA, H. IIJIMA, M. KATO, M. UCHIDA, T. WADA, M. INOUE, T. ASAO, M. FUSE, S. WADA, A. KURAMASU, R. KAMEI, S. TAKEDA, S. YAMAMOTO, S. YOSHINO, M. OKA, H. NAGANO (Yamaguchi; Tokyo; Ube; Kurashiki; Yokohama, Japan) .................................................................. 4093 Cell Cycle Arrest and Apoptosis Induced by Kinamycin F in Human Osteosarcoma Cells. A. BAVELLONI, E. FOCACCIA, M. PIAZZI, C. ERRANI, W. BLALOCK, I. FAENZA (Bologna, Italy) ................................. 4103 Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells. Y. NINOMIYA, D. YU, E. SEKINE-SUZUKI, T. NAKAJIMA (Chiba, Japan; Soochow, PR China) .......................................................... 4111 Differences in Extracellular Matrix Composition and its Role in Invasion in Primary and Secondary Intracerebral Malignancies. J. VIRGA, C.D. SZEMCSÁK, J. REMÉNYI-PUSKÁR, J. TÓTH, T. HORTOBÁGYI, É. CSŐSZ, G. ZAHUCZKY, L. SZIVOS, L. BOGNÁR, A. KLEKNER (Debrecen, Hungary) ................................ 4119 Z-360 Suppresses Tumor Growth in MIA PaCa-2-bearing Mice via Inhibition of Gastrin-induced Anti- Apoptotic Effects. Y. SHIOMI, M. YOSHIMURA, K. KUKI, Y. HORI, T. TANAKA (Kumagaya, Japan) .... 4127 Highly Eribulin-resistant KBV20C Oral Cancer Cells Can Be Sensitized by Co-treatment with the Third- generation P-Glycoprotein Inhibitor, Elacridar, at a Low Dose. Y. PARK, J.-Y. SON, B.-M. LEE, H.S. KIM, S. YOON (Suwon, Republic of Korea) ................................................................................................................... 4139 Clinical Studies Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma. H. HONJO, Y. TOH, M. SOHDA, S. SUZUKI, K. KAIRA, Y. KANAI, S. NAGAMORI, T. OYAMA, T. YOKOBORI, T. MIYAZAKI, H. KUWANO (Gunma; Fukuoka; Osaka, Japan) .............................................. 4147 Long-term Oncologic Outcomes of Robotic-assisted Radical Prostatectomy by a Single Surgeon. S.-C. HUNG, C.-K. YANG, C.-L. CHENG, Y.-C. OU (Taichung, Taiwan, ROC) ....................................................... 4157 Contents continued on the preceding page Contents continued + + The Prognostic Significance of the Tumor-infiltrating Programmed Cell Death-1 to CD8 Lymphocyte Ratio in Patients with Colorectal Cancer. M. SHIBUTANI, K. MAEDA, H. NAGAHARA, T. FUKUOKA, S. NAKAO, S. MATSUTANI, K. HIRAKAWA, M. OHIRA (Osaka, Japan) ......................................................... 4165 Anastrozole-induced Autoimmune Hepatitis: A Rare Complication of Breast Cancer Therapy. O. KLAPKO, E. GHOULAM, S. JAKATE, S. ESWARAN, L. USHA (Chicago, IL, USA) ..................................................... 4173 Cerebrospinal Fluid Penetration Rate and Efficacy of Afatinib in Patients with EGFR Mutation-positive Non- small Cell Lung Cancer with Leptomeningeal Carcinomatosis: A Multicenter Prospective Study. A. TAMIYA, M. TAMIYA, T. NISHIHARA, T. SHIROYAMA, K. NAKAO, T. TSUJI, N. TAKEUCHI, S.-I. ISA, N. OMACHI, N. OKAMOTO, H. SUZUKI, K. OKISHIO, A. IWAZAKI, K. IMAI, T. HIRASHIMA, S. ATAGI (Sakai; Habikino; Hirakata, Japan) ....................................................................................................................... 4177 Vaginal and Urine Self-sampling Compared to Cervical Sampling for HPV-testing with the Cobas 4800 HPV Test. K.C. ASCIUTTO, A.J. HENNINGSSON, H. BORGFELDT, L. DARLIN, C. BORGFELDT (Lund; Jönköping, Sweden) ................................................................................................................................................. 4183 Metabolic Rather than Pathological Response to Preoperative Chemoradiotherapy Is a Stronger Predictor of Survival in cStage IIB-IV Esophageal Cancer. S. MOTOYAMA, Y. SATO, K. MARUYAMA, S. USAMI, K. YOSHINO, T. NAKATSU, T. SASAKI, A. WAKITA, Y. KAWAKITA, J. LIU, A. ANBAI, K. ISHIYAMA, H. SAITO, Y. MINAMIYA (Akita, Japan) ............................................................................................................ 4189 Safety and Effectiveness of Laparoscopic Colorectal Resection in Elderly Patients with Colorectal Cancer: Α Propensity Score Matching Study. A. ARIMOTO, H. HASEGAWA, H. SUGIYAMA, K. YAMASHITA, T. MATSUDA, M. TOMINAGA, Y. SUMI, S. SUZUKI, Y. KAKEJI (Kobe; Akashi, Japan) .......................... 4195 Early Gastric Cancer Exfoliating into Gastric Lavage (GL1 EGC) Shows a More Aggressive Behavior and Poorer Survival Compared to the Non-Exfoliative Counterpart (GL0 EGC). E. VIRGILIO, E. GIARNIERI, M.R. GIOVAGNOLI, M. MONTAGNINI, A. PROIETTI, R. D’URSO, P. MERCANTINI, G. BALDUCCI, M. CAVALLINI (Rome, Italy) ................................................................................................................................ 4199 Venous Resection in Pancreatic Ductal Adenocarcinoma: Impact of Surgical Experience on Early Postoperative Courses. T. GUILBAUD, O. TURRINI, C. LEMOINE, Y.P. LE TREUT, M. OUAISSI, V. MOUTARDIER, J.R. DELPERO (Marseille, France) ......................................................................................... 4205 Utility of Inflammatory Marker- and Nutritional Status-based Prognostic Factors for Predicting the Prognosis of Stage IV Gastric Cancer Patients Undergoing Non-curative Surgery. K. MIMATSU, N. FUKINO, Y. OGASAWARA, Y. SAINO, T. OIDA (Kanagawa, Tokyo, Japan) ....................................................................... 4215