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Table of Contents Agenda Session Descriptions Birds of a Feather Information Birds of a Feather Descriptions Floor Plan of Bethesda North Marriott Hotel & Conference Center Poster/Demo Presentations Information Poster/Demo Presentations Index Poster/Demo Presentations Map Abstract Information Abstract Index Abstracts, in agenda order by the following topics: Research Highlights Data Commons Standards Development Training & Workforce Development BioCADDIE & Resource Indexing Software, Analysis, & Methods Development Collaborative Presentations Sustainability Keynote Speaker Biographies Open Science Prize Information Open Science Prize Fact Sheet Open Science Prize Public Voting Information Open Science Prize Advisors Dining Options Local Restaurants and Hotel Gift Shop Menu Big Data to Knowledge (BD2K) All Hands Meeting and Open Data Science Symposium November 29 - December 1, 2016 Bethesda North Marriott Hotel & Conference Center #BD2KOpenSci | #BD2K_AHM | Info: [email protected] AGENDA Tuesday, November 29, 2016 (Day 1) 7:30 a.m. – 8:30 a.m. Registration/Check-in and Poster Set-up (Registration) 8:30 a.m. – 8:45 a.m. Welcome and Meeting Organization: Jennie Larkin (Salons E-H) 8:45 a.m. – 9:15 a.m. BD2K at NIH – A Vision Through 2020: Philip Bourne NOTES 9:15 a.m. – 10:00 a.m. Keynote Address: Robert Califf, Commissioner, U.S. Food and Drug Administration 10:00 a.m. – 10:30 a.m. Coffee Break & Posters (Salons A-D) 10:30 a.m. – 12:00 p.m. Concurrent Sessions: A. Research Highlights #1 (Session Organizers: Jennie Larkin & Philip Bourne) (Salon E) NOTES B. Data Commons (Session Organizer: Vivien Bonazzi) (Salons F-H) NOTES 12:00 p.m. – 1:00 p.m. Lunch, Poster Session, & Birds-of-a-Feather (BOFs) (Various-See Floor Plan) 1:00 p.m. – 2:30 p.m. Concurrent Sessions: A. Standards Development (Session Organizers: Sherri de Coronado & Cindy Lawler) (Salon E) NOTES B. Training & Workforce Development (Session Organizer: Michelle Dunn) (Salons F-H) NOTES 2:30 p.m. – 3:00 p.m. Coffee Break & Posters 3:00 p.m. – 4:30 p.m. Concurrent Sessions: A. BioCADDIE & Resource Indexing (Session Organizers: Ron Margolis, Dawei Lin, & Ian Fore) (Salon E) NOTES B. Software, Analysis, & Methods Development (Session Organizers: David Miller & Jennifer Couch) (Salons F-H) NOTES 4:30 p.m. – 6:30 p.m. Posters, Software Demos, & BOFs (Various-See Floor Plan) Wednesday, November 30, 2016 (Day 2) 8:30 a.m. – 8:45 a.m. Roundup of Day 1 & Day 2 Activities: Jennie Larkin (Salons E-H) 8:45 a.m. – 10:00 a.m. Panel: Unmet Opportunities & Challenges Afforded by Big Data Panelists: Warren Kibbe (NCI), John J. McGowan (NIAID), Mike Huerta (NLM), James McClain (NCI), Greg Farber (NIMH), Matthew Gillman (NIH/OD) Moderator: Philip Bourne (NIH) NOTES 10:00 a.m. – 10:30 a.m. Coffee Break & Posters 10:30 a.m. – 12:00 p.m. Concurrent Sessions: A. Research Highlights #2 (Session Organizers: Jennie Larkin & Philip Bourne) (Salon E) NOTES B. Initial Implementation of the Commons (Session Organizers: Vivien Bonazzi & Valentina di Francesco) (Salons F-H) NOTES 12:00 p.m. – 1:00 p.m. Lunch, Poster Session, & BOFs (Various-See Floor Plan) 1:00 p.m. – 2:30 p.m. Concurrent Sessions: A. Collaborative Presentations (Session Organizer: Mark Guyer) (Salon E) NOTES B. Sustainability (Session Organizers: Allen Dearry & Susan Gregurick) (Salons F-H) NOTES 2:30 p.m. – 4:30 p.m. Coffee Break, Posters, & BOFs (Various-See Floor Plan) 4:30 p.m. – 5:30 p.m. Keynote Address: Chris Wiggins, Chief Data Scientist, New York Times (Salons E-H) 5:30 BD2K AHM Adjourns Open Data Science Symposium: How Open Data and Open Science Are Transforming Biomedical Research Thursday, December 1, 2016 (Day 3) Salons E-H 7:30 a.m. – 8:30 a.m. Registration/Check-in and Sign-up 8:30 a.m. – 8:40 a.m. Welcome and Meeting Objectives Elizabeth Kittrie, Senior Advisor for Data Science, NIH Philip Bourne, Associate Director for Data Science, NIH 8:40 a.m. – 9:10 a.m. Keynote Address: Vannevar Bush in the 21st Century: John Wilbanks, Chief Commons Officer, Sage Bionetworks 9:10 a.m. – 9:25 a.m. Vision and Overview of Open Science Prize: Robert Kiley, Wellcome Trust, & Philip Bourne, NIH NOTES 9:25 a.m. – 11:10 a.m. Open Science Prize Demonstration of Results Six finalist teams will present their prototypes Moderator: John Wilbanks NOTES ● OpenTrialsFDA: Making Unbiased Clinical Trial Data Accessible Enables researchers and the public to better access, search, and understand drug approval packages submitted to and made available by the Food and Drug Administration (FDA). ● Real-Time Evolutionary Tracking for Pathogen Surveillance and Epidemiological Investigation Tracks emerging diseases, such as Ebola and Zika, in a real-time online visualization platform where the outputs of statistical analyses can be used by public health professionals within days of samples being taken from patients. ● Fruit Fly Brain Observatory Pools global laboratory data to facilitate the complex scientific collaboration necessary to advance computational disease models for mental and neurological diseases by connecting data related to the fly brain. ● Open Neuroimaging Library Applies online gaming principles to advance brain research by engaging the public in collaborative annotation, discovery, and analysis of brain imaging data. ● MyGene2: Accelerating Gene Discovery via Radically Open Data Sharing Provides an open data platform for researchers, clinicians, and families affected by rare diseases to share health and genetic information to speed diagnosis, identify matching cases, and transform the process of gene discovery. ● OpenAQ: A Global Community Building the First Open, Real-Time Air Quality Data Hub for the World Provides real-time air quality information to the global public by making air quality data from around the world available in one open-source and open data platform. 11:10 a.m. – 11:30 a.m. Break 11:30 a.m. – 12:30 p.m. Open Science: An NIH Perspective: Francis Collins & Harold Varmus Moderator: Chris Wiggins, New York Times NOTES 12:30 p.m. – 1:30 p.m. Lunch 1:30 p.m. – 2:30 p.m. Panel: New Models for Supporting Open Science Across the Globe Panelists: Niklas Blomberg (ELIXIR), Peter Goodhand (GA4GH), Robert Kiley (Wellcome Trust), Tanja Davidson (NCI) Moderator: Philip Bourne, NIH NOTES 2:30 p.m. – 3:30 p.m. Viewpoints on Open Science and Open Data in Biomedical Research Panelists: Mike Huerta (NLM), Jim Anderson (DPCPSI), Mike Coburn (Research!America) Moderator: Jerry Sheehan (OSTP) NOTES 3:30 p.m. – 3:45 p.m. Closing Remarks Elizabeth Kittrie, Senior Advisor for Data Science, NIH Philip Bourne, Associate Director for Data Science, NIH Session Descriptions Research Highlights In a series of oral presentations, this session will showcase new scientific findings and impactful research being undertaken across BD2K, highlighting the breadth of activities ranging from molecules to populations. Presenters on November 29, 2016, are: 1. Soojin Park: Predicting Vasospasm After Subarachnoid Hemorrhage Using High-Frequency Physiological Data 2. Anders Dohlman: Predicting Adverse Cardiovascular Events for Tyrosine Kinase Inhibitors From Molecular Features 3. Alexander Tropsha: Hypothesis Fusion to Improve the Odds of Successful Drug Repurposing 4. David Haussler: BD2K and Global Genomic Data Sharing 5. Vikas Singh: Multi-resolution Analysis of Brain Connectivity: Associations With PET-Based Alzheimer's Pathology 6. Paul Avillach: Identification of Genotype-Phenotype Associations in Phelan-McDermid Syndrome Using Patient-Sourced Data Presenters on November 30, 2016, are: 1. Clark Glymour: Toward a Causome of the Brain 2. Wilbert Van Panhuis: Integrating Data With Epidemic Simulators to Improve Pandemic Preparedness: Chikungunya in Colombia 3. Amin Emad: Knowledge-Guided Prioritization of Genes Determinant of Drug Resistance Using ProGENI 4. Eni Halilaj: Predicting Phenotypes of Osteoarthritis Progression 5. Quynh Nguyen: Geotagged Tweets as Predictors of County-Level Health Outcomes 6. Peipei Ping: Understanding Cardiovascular Health and Revealing Pathogenic Insights via Text-Mining Approaches Moderator: Jennie Larkin Data Commons (11/29) This session will commence with an overview of the “Data Commons” and will provide updates on four major ongoing activities: the Commons Framework Pilots, the Cloud Credits Model, the Reference Datasets, and Resource Indexing. This session will also serve as a launching pad for discussion about other BD2K research activities that could synergize with the Data Commons to enable the development and implementation of a biomedical data ecosystem. Presenter: 1. Vivien Bonazzi: NIH Data Commons Overview A panel discussion will follow with NIH staff involved in the Data Commons development including: Vivien Bonazzi (NIH Data Commons, Reference Datasets); Valentina Di Francesco (Commons Framework); George Komatsoulis (Cloud Credits Model); Ian Fore, Dawei Lin, Ron Margolis, and Alison Yao (Resource Indexing). Moderator: Vivien Bonazzi Standards Development Using appropriate data‐related standards is critical for effectively transmitting, sharing, reusing, and harmonizing or integrating data. This session will focus on emerging topics in data‐related standards and highlight tools or resources that address gaps, such as finding appropriate content standards to use in research; facilitating development and reuse of Common Data Elements; facilitating traversal across connected datasets through a Commons for Identifiers; and creating a flexible, extensible, expressive exchange format to represent phenotypic