Apoptosis Inhibitor 5 (API5) (NM 006595) Human Untagged Clone Product Data

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for SC108575

Apoptosis inhibitor 5 (API5) (NM_006595) Human Untagged Clone Product data:

Product Type: Expression Plasmids Product Name: Apoptosis inhibitor 5 (API5) (NM_006595) Human Untagged Clone Tag: Tag Free Symbol: API5 Synonyms: AAC-11; AAC11 Vector: pCMV6-XL5 E. coli Selection: Ampicillin (100 ug/mL) Cell Selection: None

This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 3 Apoptosis inhibitor 5 (API5) (NM_006595) Human Untagged Clone – SC108575

Fully Sequenced ORF: >OriGene ORF within SC108575 sequence for NM_006595 edited (data generated by NextGen Sequencing) ATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGGAGCAA GTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAG GAAAAGCGATTAGCAGCTCAATTTATTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCT GATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGACGT CAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGAT ATACTAACGCAACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCC CTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAATA CTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAG ACTTTACCAGATGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAA AAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGTCTGGG TTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAG GCCGACCTAGAACAGACCTTCAATCCCTCGGATCCTGACTGTGTGGACAGGCTCTTACAG TGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTGTGACA TATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTT GATATACAGTTGGAGGTATTGAAATTGTTGGCGGAGATGAGTTCATTTTGTGGTGACATG GAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGCCCCTC CCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTC AGTTATGTGGAATGTTTGTTGTACAGTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTC TTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGTACTTT GCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGT GAGGCCTTAAAAACAGAAGAGAACAAGATTAAAGTCGTTGCATTGAAAATAACAAACAAT ATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAGTAACA CTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACA ACTTCAGGTTCACCACCCAAGAAATCTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATT TATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAACTTTAATTATGAGAGGAGC CTTCAGGGGAAGTAG

Clone variation with respect to NM_006595.3

5' Read Nucleotide >OriGene 5' read for NM_006595 unedited Sequence: TTGTAATACGACTTCACTATAGGGCGGCCGCGAATCGGCACGAGGTGGAGGTGTAATAGT GCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGGACAAGGATAG CGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAAT TATGGCATCCTGGCCGATGCCACGGAGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTG ATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTCCG AAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTC TGTGAGGATGAAGATGTATCTATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCC ACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATGAC TCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAA GGGACTTTAGGTGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGA GCAATTAAATTCCTTTCTACAAAACTTAAGACTNTACCAGATGAAGTCTTAACAAAGGAA GTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAA ATTGTTCTATTTATGAAGATACTGTCTGGGTTAAAAAGCCTACAGACAGTGAGTGGAAGA ACAGCACTTGTAAAGNTGGTGGCTGAACAGGCCGACCTAAAACAGACCTTCATCCCTTGG ATCCTGACTGGGTGGACAGCTCTTACAGTGCACTCGGCAGGCAGTCCCCCTCTTTCTAAA ATGTCCATTCCCAGGNTTGTGACATATTCTG

This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 3 Apoptosis inhibitor 5 (API5) (NM_006595) Human Untagged Clone – SC108575

3' Read Nucleotide >OriGene 3' read for NM_006595 unedited Sequence: GAAATTTATTTCAAGACTAGGGCGACTTCACTTCAAACAGAGATAAACAGGTGTCTTGCA AAAGAAAAAAATCCATGGCATTAAGTTTTTCATTCAAATTCGGAAGCAAAAATAACCTAA GTTGTGCACTATTGCCTTAGGAAAGGGAAGGGGAAGGGCGAGGGATAAGGGAACAGCCAA CTCAGTATCACACTTGATAAAGTAAAGTCACTTTCTGCTCAGTTCTGAGTTCACAAATAT GCTTATAATGACCAAAAGCGGTAACATTATATTCAATGTTCAAATTTATTTATCTGTAGT TTTTATAATTTCTGTACTTGAAATCGGCTTTGGGCCACTGGCTGATCCATTTTTGAGGTC CAGATTAGCTGGTCAGTCTTCAAACGGCAACTTTATATTTCTTTGTTCATACTCCAAGGG AGTTTCTGTCCATTTTATGGTCTTTTGCAATGCCCACAGACTATTGCCACCACTTCCATA GCCCATCTGACCAACTGTTGCTCACTTGCATCATCCTACCTCTTTCAGAACTATTTTTCC CATACAACACGTCCATTAATTCTATATAAGGCACTTTGCCTCCTTTAGATTGCCCACGTT CTGTTTACCAACAACACCCGCACTTGGACCCTACATATCCTTCATTAAATTCCTCACCCT ACTACACACGCCATTCAGTAACCTTGACCAATTACCACATTTGGTGCCCATAATATCCAT CTGCTTATCTTACACCCTTTCACTTTCACATTCCACCCTCGTTTTTTGCTTCCCCATTGT TCCCGAATTTTAAATCCGCTATCCGTTTTTTGCCCCTTATCTCCCTTCCCCTTTTTTACT CAAAATATTCCGATTCCACACCCTCCACTCAACCTACAACCGTCAATTTTTCCCACCACC CGTTTTTACTGGTCCTGCCCTCCCCCCTTTTCGGGGTTCCCCTCGATTTCACCGCAATTA CTCCTCCCTTGTAACACTTTACTCAGT Restriction Sites: NotI-NotI ACCN: NM_006595 Insert Size: 3300 bp OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). RefSeq: NM_006595.2, NP_006586.1 RefSeq Size: 3752 bp RefSeq ORF: 1515 bp Locus ID: 8539

UniProt ID: Q9BZZ5 Protein Families: Druggable Genome Gene Summary: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] Transcript Variant: This variant (2) lacks a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct C-terminus, compared to isoform a.