mTORC1 upregulation via ERK-dependent gene expression Title change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Komatsu, Naoki; Fujita, Yoshihisa; Matsuda, Michiyuki; Aoki, Author(s) Kazuhiro Citation Oncogene (2015), 34(45): 5607-5616 Issue Date 2015-11-05 URL http://hdl.handle.net/2433/207613 This is the accepted manuscrip of the article is available at http://dx.doi.org/10.1038/onc.2015.16.; The full-text file will be made open to the public on 5 May 2016 in accordance with Right publisher's 'Terms and Conditions for Self-Archiving'.; この論 文は出版社版でありません。引用の際には出版社版をご 確認ご利用ください。; This is not the published version. Please cite only the published version. Type Journal Article Textversion author Kyoto University 1 Title mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Authors Naoki Komatsu1, Yoshihisa Fujita2, Michiyuki Matsuda1,2, and Kazuhiro Aoki3 Affiliations 1. Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Japan 2. Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan 3. Imaging Platform for Spatio-Temporal Information, Graduate School of Medicine, Kyoto University, Japan To whom correspondence should be addressed Kazuhiro Aoki, Imaging Platform for Spatio-Temporal Information, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Tel.: 81-75-753-9450; Fax: 81-75-753-4698; E-mail:
[email protected] Running title (less than 50 letters and spaces): Transcriptional control of mTORC1 activity by ERK 2 Abstract Cancer cells harboring oncogenic BRaf mutants, but not oncogenic KRas mutants, are sensitive to MEK inhibitors (MEKi).