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NEUPOGEN (Filgrastim) Patient Guide

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NEUPOGEN (Filgrastim) Patient Guide NEUPOGEN® (filgrastim) Patient Guide What is NEUPOGEN®? NEUPOGEN® should be injected at least 24 hours If you are giving someone else NEUPOGEN® NEUPOGEN® is a man-made form of granulocyte before your next dose of chemotherapy. injections, it is important that you know how to inject colony-stimulating factor (G-CSF), which is made There is more information about NEUPOGEN® in the NEUPOGEN®, how much to inject, and how often to using the bacteria Escherichia coli. G-CSF is a substance Physician Package Insert. If you have any questions, you inject NEUPOGEN®. naturally produced by the body. It stimulates the growth should talk to your doctor. NEUPOGEN® is available as a liquid in vials of neutrophils (nu-tro-fils), a type of white blood cell What are possible serious side effects of or in prefilled syringes. When you receive your important in the body’s fight against infection. NEUPOGEN®? NEUPOGEN®, always check to see that: ® What is NEUPOGEN used for? • Spleen Rupture. Your spleen may become enlarged • The name NEUPOGEN® appears on the package NEUPOGEN® is a prescription medication used to and can rupture while taking NEUPOGEN®. A and vial or prefilled syringe label. reduce the risk of infection in patients with some ruptured spleen can cause death. The spleen is located • The expiration date on the vial or prefilled syringe tumors, who are receiving strong chemotherapy that in the upper left section of your stomach area. Call label has not passed. You should not use a vial or may cause severe neutropenia (nu-tro-peen-ee-ah), your doctor right away if you/your child has pain in prefilled syringe after the date on the label. with fever. Neutropenia is a condition where the body the left upper stomach area or left shoulder tip area. • The strength of the NEUPOGEN® (number of makes too few neutrophils. Neutropenia may be a long- This pain could mean your/your child’s spleen is micrograms in the colored dot on the package standing condition where your body does not make enlarged or ruptured. containing the vial or prefilled syringe) is the same as enough neutrophils or it may be caused by drugs used • Serious Allergic Reactions. NEUPOGEN® can your doctor prescribed. to treat cancer. In some cases, your body may make cause serious allergic reactions. These reactions enough neutrophils but as part of your treatment for • The NEUPOGEN® liquid in the vial or in the can cause a rash over the whole body, shortness of prefilled syringe is clear and colorless. Do not use cancer your doctor may want to increase the number breath, wheezing, dizziness, swelling around the of certain blood cells (CD34 cells) and collect them. NEUPOGEN® if the contents of the vial or prefilled mouth or eyes, fast pulse, and sweating. If you or syringe appear discolored or cloudy, or if the vial or The cells are collected using a process called apheresis your child starts to have any of these symptoms, ree prefilled syringe appears to contain lumps, flakes, or (ay-fer- -sis). These collected cells are given back to stop using NEUPOGEN® and call your doctor or you after you receive very high doses of treatment for particles. seek emergency care right away. If you/your child ® cancer to make your blood counts get back to normal has an allergic reaction during the injection of If you are using vials of NEUPOGEN more quickly. NEUPOGEN®, stop the injection right away. only use the syringe that your doctor ® prescribes. How does NEUPOGEN work? • A serious lung problem called acute respiratory Your doctor or nurse will give you instructions on how NEUPOGEN® works by helping your body make more distress syndrome (ARDS). Call your doctor or to measure the correct dose of NEUPOGEN®. This neutrophils. To make sure NEUPOGEN® is working, seek emergency care right away if you/your child has dose will be measured in milliliters. You should only use your doctor will ask that you have regular blood tests shortness of breath, trouble breathing or a fast rate a syringe that is marked in tenths of milliliters, or mL to count the number of neutrophils you have. It is of breathing. important that you follow your doctor’s instructions (for example, 0.2 mL). The doctor or nurse may refer about getting these tests. What are the most common side effects to an mL as a cc (1 mL = 1 cc). If you do not use the of NEUPOGEN®? correct syringe, you/your child could receive too much ® Who should not take NEUPOGEN ? The most common side effect you/your child may or too little NEUPOGEN®. Do not take NEUPOGEN® if you are: experience is aching in the bones and muscles. This Only use disposable syringes and needles. Use the • Allergic to NEUPOGEN® (filgrastim) or any of aching can usually be relieved by taking a non-aspirin syringes only once and dispose of them as instructed its ingredients. See the end of this page for a list of pain reliever such as acetaminophen. by your doctor or nurse. ingredients in NEUPOGEN®. Some people experience redness, swelling, or itching How should NEUPOGEN® be stored? • Allergic to other medicines made using the bacteria at the site of injection. This may be an allergy to the NEUPOGEN® should be stored in the refrigerator E coli. Ask your doctor if you are not sure. ingredients in NEUPOGEN® or it may be a local at 2° to 8°C (36° to 46°F), but not in the freezer. reaction. If you are giving an injection to a child, look What important information do I need to Avoid shaking NEUPOGEN®. If NEUPOGEN® is for signs of redness, swelling, or itching at the site of know about taking NEUPOGEN®? accidentally frozen, allow it to thaw in the refrigerator injection because they may not be able to tell you they NEUPOGEN® may reduce your chance of getting before giving the next dose. However, if it is frozen a are experiencing a reaction. If you notice any signs of a Frequently Asked Questions an infection, but does not prevent all infections. An second time, do not use it and contact your doctor or local reaction, call your doctor. infection can still happen during the short time when nurse for further instructions. your/your child’s neutrophil levels are low. You must What about pregnancy or breastfeeding? NEUPOGEN® can be left out at room temperature for be alert and look for some of the common signs or NEUPOGEN® has not been studied in pregnant up to 24 hours. Do not leave NEUPOGEN® in direct symptoms of infection, such as fever, chills, rash, sore women, and its effects on unborn babies are not known. sunlight. If you have any questions about storage or throat, diarrhea, redness, swelling, or pain around a If you take NEUPOGEN® while you are pregnant, it how to carry NEUPOGEN® when you travel, contact cut or sore. If you/your child has any of these signs or is possible that small amounts of it may get into your your doctor, nurse, or pharmacist. symptoms during treatment with NEUPOGEN®, tell baby’s blood. It is not known if NEUPOGEN® can get ® your doctor or nurse immediately. into human breast milk. What are the ingredients in NEUPOGEN ? Each prefilled syringe and vial contains filgrastim in If you are pregnant, plan to become pregnant, think you There is a possibility that you/your child could have a a sterile, clear, colorless, preservative-free solution may be pregnant, or are breast feeding, you should tell reaction at an injection site. If there is a lump, swelling, containing acetate, sorbitol, polysorbate 80, and sodium. or bruising at an injection site that does not go away, your doctor before using NEUPOGEN®. If you become call your doctor. pregnant during NEUPOGEN® treatment, you are The needle cover on the single-use prefilled syringe encouraged to enroll in Amgen’s Pregnancy Surveillance contains dry natural rubber (latex), which should not If you have a sickle cell disorder, make sure that you tell be handled by persons sensitive to this substance. your doctor before you start taking NEUPOGEN®. If Program. You should call 1-800-77-AMGEN you have a sickle cell crisis after getting NEUPOGEN®, (1-800-772-6436) to enroll. tell your doctor right away. How to prepare and give a NEUPOGEN® Please see the following pages for injection? Talk to your doctor if you experience unusual bleeding detailed instructions for: or bruising while taking NEUPOGEN®, as this could NEUPOGEN® should be injected at the same time each • Setting up for an injection mean a decrease of platelets which reduces the ability of day. If you miss a dose contact your doctor or nurse. blood to clot. • Preparing your dose of NEUPOGEN® You must always use the correct dose of NEUPOGEN®. • Selecting and preparing the injection site Make sure your doctor knows about all medicines, and Too little NEUPOGEN® may not protect you against • Injecting the dose herbal or vitamin supplements you are taking before infections, and too much NEUPOGEN® may cause too • Disposing of syringes, needles, vials and starting NEUPOGEN®. If you are taking lithium you many neutrophils to be in your blood. Your doctor will may need more frequent blood tests. determine your/your child’s correct dose based on your/ needle guards If you/your child are receiving NEUPOGEN® because your child’s body weight. you are also receiving chemotherapy, the last dose of Please see full Indication and Important Safety Information on page 4 1 If You Are Using NEUPOGEN® in a Vial Setting up for an injection 1.
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