Protocol Supplementary

Home , Clodronic acid, Etidronic acid, Minodronic acid, Pamidronic acid, Risedronic acid, Tiludronic acid

Optimal Pharmacological Management and Prevention of Glucocorticoid-Induced Osteoporosis (GIOP) Protocol for a Systematic Review and Network Meta-Analysis

Supplementary Materials: Sample Search Strategy Supplementary 1: MEDLINE Search Strategy

Database: OVID Medline Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present

Line

1 exp Osteoporosis/

2 osteoporos?s.ti,ab,kf.

3 Bone Diseases, Metabolic/

4 osteop?eni*.ti,ab,kf. 5 Bone Diseases/

6 exp Bone Resorption/

7 malabsorption.ti,ab,kf.

8 Bone Density/ 9 BMD.ti,ab,kf.

10 exp Fractures, Bone/

11 fracture*.ti,ab,kf.

12 (bone* adj2 (loss* or disease* or resorption* or densit* or content* or fragil* or mass* or demineral* or decalcif* or calcif* or strength*)).ti,ab,kf. 13 osteomalacia.ti,ab,kf.

14 or/1-13

15 exp Glucocorticoids/

16 exp Steroids/ 17 (glucocorticoid* or steroid* or prednisone or prednisolone or hydrocortisone or cortisone or triamcinolone or dexamethasone or betamethasone or methylprednisolone).ti,ab,kf. 18 or/15-17

19 14 and 18

20 ((glucocorticoid-induced or glucosteroid-induced or corticosteroid-induced or glucocorticosteroid-induced) adj1 osteoporos?s).ti,ab,kf. 21 19 or 20

22 exp Diphosphonates/

23 (bisphosphon* or diphosphon*).ti,ab,kf. 24 exp organophosphates/ or organophosphonates/

25 (organophosphate* or organophosphonate*).ti,ab,kf.

26 (alendronate or alendronic acid or Fosamax or Binosto or Denfos or Fosagen or Lendrate).ti,ab,kf.

27 (Densidron or Adrovance or Alenotop or Alned or Dronat or Durost or Fixopan or Forosa or Fosval or Huesobone or Ostemax or Oseolen or Arendal or Beenos or Berlex or Fosalen or Fosmin or Fostolin or Fosavance).ti,ab,kf. 28 (clodronic acid or etidronic acid or ibandronic acid or pamidronate or risedronic acid or zoledronic acid).ti,ab,kf. 29 (etidronate or Didrocal or Didronel or Etidrocal or etidronatecal or Etidron or hydroxyethanediphosphonic acid or oxyethylidenediphosphonic acid).ti,ab,kf. 30 (risedronate or Actonel or Atelvia or Benet or Ridron).ti,ab,kf.

31 (zoledronate or Aclasta or Reclast or Zometa).ti,ab,kf.

32 (ibandronate or Bondronat or Boniva or Bonviva or Iasibon or Adronil).ti,ab,kf.

33 (tiludronate or tiludronic acid or Skelid).ti,ab,kf.

34 (pamidronate or Aredia or Aminomux or Pamimed or Ribodroat or Bonin).ti,ab,kf.

35 (clodronate or Bonefos or Clasteon or Ostac Cap or Lodronat or Loron or Lytos or Ostac or Sindronat).ti,ab,kf. 36 exp Bone Density Conservation Agents/

37 (bone modifying agent* or bone density conservation agent*).ti,ab,kf.

38 (RANKL Inhibitor or denosumab).ti,ab,kf.

39 hormones/ or exp estrogens/

40 (estrogen or estradiol or estrace or innofem or vagifem or minivelle or yuvafem or premarin or progesterone or estradiol or vivelle or menostar or climara or alora or estraderm or oestradiol or estropipate or ogen or ethinylestradiol or Prempro or premphase or bazedoxifene or duavee or medroxyprogesterone).ti,ab,kf. 41 (phytoestrogen* or Coumestrol or Isoﬂavone or Isoﬂavon).ti,ab,kf.

42 (calcitonin or miacalcin or calcimar or cibacalcin or Fortical or thyrocalcitonin or Calcitare).ti,ab,kf.

43 (SERM* or raloxifene or Evista or Optruma or Keoxifene).ti,ab,kf.

44 exp Parathyroid Hormone/

45 (parathyroid hormone* or parathormone* or teriparatide* or Forteo or Forsteo).ti,ab,kf.

46 Parathyroid Hormone-Related Protein/ 47 exp Anabolic Agents/

48 (abaloparatide or anabolic agent* or Tymlos).ti,ab,kf.

49 (Sclerostin Inhibitor* or romosozumab or strontium ranelate or ranelic acid or Evenity or Osseor or Protelos).ti,ab,kf.

50 (calcium or vitamin D or nutraceutical or caltrate or ridactate or Calciferol or citracal or posture or Ostoforte or calcitrate or antacids or Cal-Lac or Radiostol or cholecalciferol or alfacalcidol).ti,ab,kf. 51 or/22-50

52 21 and 51

53 exp randomized controlled trial/

54 exp Randomized Controlled Trials as Topic/

55 randomized controlled trial.pt.

56 random*.mp.

57 double-blind method/ or single-blind method/

58 ((singl* or doubl* or tripl* or trebl*) adj3 (blind* or mask* or procedure* or method*)).mp.

59 systematic review*.mp.

60 systematic review.pt.

61 meta analys?s.mp.

62 meta-analysis/ or "systematic review"/

63 or/53-62

64 52 and 63

65 animals/ not (humans/ and animals/)

66 64 not 65 Supplementary 2: CNKI Search Strategy * “+” is equivalent to “OR”, “*” is equivalent to “AND”, “-” is equivalent to “NOT” ((‘bisphosphonate'+'diphosphonates'+'双磷酸盐'+'⼆磷酸盐'+'⼆膦酸盐'+'双膦酸盐'+'alendronate'+'alendronic acid'+'Fosamax'+'阿伦膦酸'+'阿屈膦酸'+'阿仑膦酸'+'阿仑特罗'+'阿伦磷酸'+'阿屈磷酸'+'阿仑磷酸'+'阿伦特罗'+'阿仑棒酸'+'阿伦棒酸'+'福善美'+'固邦'+'天可'+'etidronate'+'etidronic acid’+’EHDP'+'依替膦酸'+'依替磷酸'+'羟⼄膦酸'+'羟⼄磷酸'+'邦特林'+'依膦'+'正⼤天晴'+'根德')*('risedronate'+'risedronic acid'+'利塞膦酸'+'利塞磷酸'+'积华固松'+'利噻膦酸'+'利噻磷酸'+'吉威'+'唯善''zoledronate'+'zoledronic acid'+'Aclasta'+'Zometa'+'唑来膦酸'+'唑来磷酸'+'天晴依泰'+'择泰'+'艾瑞宁'+'健润'+'震达'+'盖柠'+'卓莱'+'盖柠'+'艾朗'+'因⼒达'+'佐锐 '+'苏奇 '+'博来宁'+'密固达'+'ibandronate'+'ibandronic acid’+’伊班膦酸’+'伊班磷酸'+'艾本'+'邦罗⼒'+'佳诺顺')*('tiludronate'+'tiludronic acid'+'Skelid'+'替鲁膦酸'+'替鲁磷酸'+'替鲁罗酸'+'替⻧屈酸'+'pamidronate'+'pamidronic acid'+'Aredia'+'Bonin'+'帕⽶膦酸'+'帕⽶磷酸'+'博宁'+'仁怡'+'阿可达'+'clodronate'+'clodronic acid'+'Bonefos'+'氯膦酸钠'+'氯磷酸钠'+'氯屈膦酸'+'氯屈磷酸'+'德维'+'迪盖纳'+'雅坤宇'+'固令'+'minodronate'+'minodronic acid’+’⽶诺膦酸'+'⽶诺磷酸')*('RANKL Inhibitor'+'靶向NF-κB受体活化因⼦配体'+'全⼈源抗体'+'RANKL 抗体’+’denosumab'+'Prolia'+'AMG-162'+'Xgeva'+'Ranmark'+'地诺单抗'+'狄诺塞⻨'+'Hormone'+'steroid'+'激素'+'荷尔蒙'+'estrogen'+'雌激素'+'倍美⼒')*('calcitonin'+'salmon calcitonin'+'miacalcin'+'降钙素'+'鲑降钙素'+'邦瑞得'+'固泰宁'+'eel calcitonin'+'porcine calcitonin'+'盖瑞宁'+'翰欣'+'达芬盖'+'考克'+'密盖息'+'Selective Estrogen Receptor Modulators’+’SERM'+'选择性雌激素受体调节剂')*('raloxifene'+'Evista'+'Optruma'+'Keoxifene'+'雷洛昔芬'+'盐酸雷洛昔芬'+'易维特'+'Parathyroid'+'Hormone'+'parathormone'+'PTH'+'甲状旁腺激素'+'teriparatide'+'Forteo'+'Forsteo'+'特⽴帕肽'+'复泰奥')*('PTHrp'+'甲状旁腺激素相关蛋⽩类似物'+'abaloparatide'+'Tymlos'+'阿巴帕肽'+'Sclerostin Inhibitor'+'sclerostin antibody’+'硬化素抑制剂'+'硬化素抗体'+'romosozumab'+'AMG-785'+'Evenity'+'罗莫索单抗')*('strontium ranelate'+'ranelic acid'+'Osseor'+'Protelos'+' '+'雷奈酸锶'+'欧思美'+'Supplement'+'calcium'+'钙'+'葡萄糖酸钙'+'vitamin D’+’Calciferol’+'cholecalciferol'+'alfacalcidol'+'阿法⻣化醇'+'胆维丁'+'维⽣素 D'))*('glucocorticoid'+'glucosteroid'+'corticosteroid'+'steroid'+'glucocorticostero id'+'糖⽪质'+'糖⽪质素'+'糖⽪质激素'+'激素'+'prednisone'+'肾上腺'+'肾上腺素'+'肾上腺激素'+'强的松'+'泼尼松'+'prednisolone'+'泼尼松⻰'+'hydrocortisone'+'氢化可的松'+'cortisone'+'bethamethasone'+'倍他⽶松'+'triamcinolone'+'曲安奈德'+'dexamethasone'+'地塞⽶松'+'氟美松'+'地噻⽶松'+'类固醇'+'betamethasone'+'倍他⽶松'+'methylprednisolone'+'甲泼尼⻰'+'甲基泼尼松⻰'+'甲基强的松⻰'+'甲泼尼松⻰'+'甲强⻰')*('glucocorticoid- induced'+'glucosteroid-induced'+'corticosteroid-induced'+'steroid- induced'+'glucocorticosteroid-induced'+'糖⽪质激素性⻣质疏松'+'糖⽪质激素性⻣质疏松'+'GIOP'+'糖⽪质激素诱导⻣质疏松'+'糖⽪质激素引发的⻣质疏松'+'osteoporosis'+'⻣质疏松'+'fracture'+'Autoimmune disease'+'bone loss’+'⾃身免疫性疾病'+'红斑狼疮'+'哮喘')*('randomized controlled trial'+'RCT'+'随机'+'randomize'+'randomized'+'inferiority'+'双盲'+'control'+'controlled'+'单盲'+'trial'+'clinical trial’+’placebo’+’开放’+’dummy’+’blind’+’placebo- controlled’+’prospective’+’crossover’+’non-inferiority’+’open-label’+’double- blind’+’triple-blind’+'double-dummy')-('动物'-'animal'-'⿏'-'兔'-'狗'-'⽺')