Valarie Kerschen M.D. € Greek word meaning “self” € 1940’s – Dr Leo Kanner describes classic € 1940’s – Dr Hans Asperger describes Aspergers Syndrome € 1960’s – Autism theorized to be due to “refrigerator mothers” € 1967 – classified under schizophrenia € 1980 – classified as a developmental disorder € 1994 – Aspergers Syndrome added to the classification of Autism Disorders € 1990 – Children with Autism deemed eligible for special education services € Once considered to be a rare disorder

€ Current research indicates that 1 out of 150 children have an disorder € Changes in diagnostic criteria

€ Inclusion of Aspergers Disorder in 1994

€ Diagnostic substitution

€ Real increase in numbers????????????? € Exact cause of Autism is unknown

€ Considerable research being conducted to determine cause or causes

€ Unlikely to find one major cause due to the variability and complexity in symptoms of Autism € More common in boys 4-6 boys: 1 girl € Recurrence risk – 5-6% if have one sibling with autism and may be as high as 25% if more than one sibling w/ Autism € Studies have implicated sites on nearly every chromosome € Identical twins have a concordance rate of 60% € Fragile X Syndrome € Tuberous Sclerosis € Angelman syndrome € Smith-Lemli-Opitz Syndrome € Fetal Alcohol Syndrome € Prematurity € Prenatal exposure to certain medications € Advanced maternal or paternal age € Living in areas with high amounts of precipitation € Environmental exposures € Changes in brain pathology € Concern over vaccines or the preservatives in vaccines as a causative factor in the development of Autism € Thimerisol ( a vaccine preservative) has been removed from childhood vaccines with no decrease in rates of autism € Institute of Medicine (2001) concluded that no evidence of association found between the MMR vaccine and autism € Diagnostic criteria are published in the Diagnostic and Statistical Manual of Mental Disorders -IV € Pervasive Developmental Disorder • Autism • Aspergers Disorder • Pervasive Developmental Disorder (not otherwise specified) PDD(NOS) • Retts Syndrome • Childhood Disintegrative Disorder € Broad term used to describe the Pervasive Developmental Disorders • Autism • Aspergers • Pervasive Developmental Disorder(Not otherwise specified) € Deficits in Social Interaction Skills

€ Impairment in Communication Skills

€ Repetitive behaviors € Impairment in use of non-verbal behaviors to modulate social interaction € Failure to develop peer relationships € Lack of spontaneously seeking to share enjoyment or interests with others € Lack of social or emotional reciprocity € Delay or total lack of spoken language € In individuals with speech, lack of ability to maintain conversation € Repetitive use of language or idiosyncratic language € Lack of varied spontaneous or make- believe play € Encompassing preoccupation or restricted pattern of interest € Inflexible adherence to nonfunctional routines € Stereotyped and repetitive motor mannerisms € Persistent preoccupation with parts of objects € Current diagnostic criteria may not be applicable to children under the age of three – yet we know we can identify children with autism as young as 14 months € Disordered development is common in children with autism • Examples include learning the alphabet before being able to ask for a drink of milk € More specific for autism than delayed language development

€ Typically more subtle

€ Less universally recognized

€ Characterized by aloofness, difficulty with eye contact, content to play alone € Joint attention – probably the single best predictor of autism in young children € Normal joint attention characterized by the joy a child shows when sharing his interests with another € Early on is manifested with use of gaze and later on matures into use of speech and gestures € Spontaneous (8 – 10 months) • Infant is able to follow a parents shift in gaze € Responding (10 – 12 months) • “follow a point”

€ Initiating (12 -16 months) • Requesting • Commenting € Turns when name is called (8 – 10 month) € Many parents who have children with autism first had concerns about their child's hearing € Simple pretend play (16 – 18 months) • Use representative objects to pretend such as telephone or bottle € Complex pretend play (18 – 20 months) • Use generic items to pretend such as using a banana as a phone € Prelinguistic • Unusually quiet , little babbling, atypical vocalizations • Fewer gestures – lifting arms to be picked up, waving, pointing € Linguistic • Delay or lack of language, unusual language development, echolalia, “pop-up” words € Attachment to unusual objects

€ Repetitive motor movements € 25 – 30% have regression in communications skills and social interaction skills

€ Typically occurs between 12 – 24 months € Visual

€ Tactile

€ Oral

€ Motor € Cognitive Abnormalities • Cognitive delay / MR • Splinter Skills € Seizures • 11-39% and correlation with degree of cognitive delay • 2 peaks before age 5 and adolescence € Sleep Disturbances

€ Behavior • Hyperactivity • Aggression • Self-Injurious Behavior € Educational Interventions • Socialization • Communication • Adaptive skills • Behavioral interventions • Academics € Behavior analytic • Applied behavior Analysis / Lovaas

€ Structured • TEACCH

€ Developmental • Greenspan / model € Early entry € Intensive intervention € Low student-to-teacher ratio € Family teaching € High degree of structure € Speech and language therapy

€ Occupational therapy € Dietary interventions • GFCF diet

€ Dietary supplements • Vitamin B6, DMG, Magnesium

€ Chelation therapy € Identification and Evaluation of Children with Autism Spectrum Disorders , Pediatrics volume 120, Number 5, Nov 2007 € Management of Children with Autism Spectrum Disorders, Pediatrics Volume 120, Number 5 November 2007 € Recognition of Autism Before Age 2 Years, Pediatrics in Review Volume 29, Number 3, March 2008