To Induce Cytotoxicity of Ovarian Cancer Cells Through Increased Autophagy and Apoptosis
Endocrine-Related Cancer (2012) 19 711–723 Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis Nan Liu1,2, Sheng Tai2,4, Boxiao Ding2, Ryan K Thor2, Sunita Bhuta2, Yin Sun2 and Jiaoti Huang2,3 1Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People’s Republic of China 2Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California at Los Angeles, 10833 Le Conte Avenue, 13-229 CHS, Los Angeles, California 90095-1732, USA 3Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, California, USA 4Department of Urology and Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China (Correspondence should be addressed to N Liu at Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University; Email: nanobgyn1225@gmail.com; J Huang at Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California at Los Angeles; Email: jiaotihuang@mednet.ucla.edu) Abstract Phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway plays a key role in the tumorigenesis of a variety of human cancers including ovarian cancer. However, inhibitors of this pathway such as Rad001 have not shown therapeutic efficacy as a single agent for this cancer. Arsenic trioxide (ATO) induces an autophagic pathway in ovarian carcinoma cells. We found that ATO can synergize with Rad001 to induce cytotoxicity of ovarian cancer cells.
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