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ASCO 2017 WEBCAST Elacestrant (RAD1901) June, 4, 2017 ASCO 2017 WEBCAST Elacestrant (RAD1901) June, 4, 2017 Disclaimer: RAD1901 is an investigational agent NASDAQ: RDUS Please refer to the ASCO 2017 poster for complete details Safe Harbor Any statements made in this presentation relating to future financial or business performance, conditions, plans, prospects, trends or strategies and other financial or business matters, including expectations regarding the development and potential commercialization of our product candidates, clinical trial results, regulatory actions, potential collaborations, future revenues and operating expenses, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In addition, when used in this presentation, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict”, “target” and similar expressions and their variants, as they relate to Radius Health, Inc. (“Radius”) or its management, may identify forward-looking statements. Radius cautions that these forward-looking statements are subject to numerous assumptions, risks and uncertainties, which change over time. Important factors that may cause actual results to differ materially from the results discussed in the forward-looking statements or historical experience include, without limitation, risks and uncertainties regarding the progress of abaloparatide-SC in the regulatory process in Europe and the timing of potential regulatory actions; progress in the development of our product candidates; our failure to secure and maintain relationships with collaborators; risks relating to clinical trials; risks relating to the commercialization of TYMLOS™ in the U.S., or potential commercialization of any of our proposed product candidates, if approved (such as marketing, regulatory, patent, product liability, supply, competition and other risks); dependence on the efforts of third parties; dependence on and potential challenges to our intellectual property; and risks that we may lack the financial resources and access to capital to fund our operations. Further information on the factors and risks that could affect Radius’ business, financial conditions and results of operations and could cause actual results to differ materially from those indicated by the forward-looking statements made in this presentation are contained under the caption “risk factors” in Radius’ Annual Report on Form 10-K for the period ended December 31, 2016, filed with the U.S. Securities and Exchange Commission (SEC) on February 24, 2017, along with Radius’ most recent quarterly and other reports filed with the SEC. The forward-looking statements represent Radius’ estimate as of the date of this presentation only, and Radius specifically disclaims any duty or obligation to update forward-looking statements. | 2 3 Agenda TOPIC PRESENTER Welcome Barbara Ryan, IR Elacestrant Update Alison O’Neill, MD, VP, Oncolcgy Clinical Development Breast Cancer Treatment Landscape Gary Hattersley, PhD, Scientific Officer Commercial Opportunity Robert Ward, President and CEO Q&A | 3 Elacestrant Update Maturing data presented at ASCO 2017 on the US Ph1 Dose Escalation & Expansion study Data Presented at ASCO 2017 • Impressive single agent activity in heavily pre-treated ER+ breast cancer patients • Objective Response Rate (ORR) of 23% in patients with RECIST measurable disease at baseline • Clinical Benefit Rate (CBR) at 24 weeks of 42%* • Median Progression Free Survival (mPFS) of 4.5 months* • Responses documented in patients with prior fulvestrant therapy, prior CDK4/6i therapy and in patients with ESR1 mutations • 15 patients continue on treatment as of April 28, 2017 * In patient group with mature data for estimation (Parts A+B) 4 Evaluation of elacestrant (RAD1901), a novel oral investigational, selective estrogen receptor degrader (SERD), for the treatment of ER positive (ER+) advanced breast cancer (mBC) Aditya Bardia1, Peter Kabos2, Richard Elledge3, Dannie Wang4, Jinshan Shen4, Fiona Garner4, Alison O'Neill4, Virginia G. Kaklamani3 1Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA; 2University of Colorado Denver, Greenwood Village, CO; 3CTRC, University of Texas Health Science Center San Antonio, San Antonio, TX; 4Radius Health Inc., Waltham, MA 5 Phase 1 dose escalation and expansion study design • Study Objectives • Primary: define recommended Phase 2 dose • Secondary: safety and tolerability, pharmacokinetics (PK), preliminary anti-tumor effect, and evaluation of circulating tumor DNA (ctDNA; exploratory objective) • Response evaluations performed every 8 weeks following RECIST v1.1 guidelines • Patient population ER+/HER2- postmenopausal women with mBC • ≤2 prior chemotherapies in the advanced or metastatic setting • No limit on number of prior endocrine therapies 6 Patient Demographics Median of 3 prior systemic therapies ‒ 38% had previously received fulvestrant ‒ 40% had previously received CDK4/6 inhibitor therapy ‒ 30% had received >1 prior line of chemotherapy ‒ 50% were ESR1 mutant 7 Objective Response Rates (ORR) in ER+ Advanced Breast Cancer for Endocrine Agents Range from 2.1%* (mono) to 19%* (in combo) 25% 2nd line SERD combo 2nd line mTOR combo nd 7-9% Fulvestrant 2 line (SOFEA, PALOMA-3) 3rd line 2.1% Fulvestrant 0% (BELLE-3) monotherapy ORR *ORR is based on ITT 8 Objective Response Rates (ORR) in ER+ Advanced Breast Cancer for Endocrine Agents Range from 2.1%* (mono) to 19%* (in combo) 25% nd 19% Fulvestrant +Palbociclib 2 line (PALOMA-3) SERD combo 2nd line 9.5% Exemestane + Everolimus (BOLERO-2) combinations mTOR combo nd 7-9% Fulvestrant 2 line (SOFEA, PALOMA-3) 3rd line 2.1% Fulvestrant 0% (BELLE-3) monotherapy ORR *ORR is based on ITT 9 Elacestrant single agent ORR 23% in heavily pre-treated patients • 22 patients had RECIST measurable disease • 5 confirmed partial responses • 9 patients with stable disease • Confirmed responses observed in patients with prior fulvestrant, prior CDK4/6i therapy, and ESR1mut as well as wildtype 10 Clinical Benefit Rates (CBR) in ER+ Advanced Breast Cancer for Endocrine Agents Range from 15.4%* (mono) to 67%* (in combo) 70% 2nd line SERD combo 2nd line mTOR combo nd 32-40% Fulvestrant 2 line (SOFEA, PALOMA-3) rd 15.4% Fulvestrant 3 line (BELLE-3) 0% monotherapy CBR *CBR is based on ITT 11 Clinical Benefit Rates (CBR) in ER+ Advanced Breast Cancer for Endocrine Agents Range from 15.4%* (mono) to 67%* (in combo) 70% nd 67% Fulvestrant +Palbociclib 2 line (PALOMA-3) SERD combo nd 51.3% Exemestane + Everolimus 2 line (BOLERO-2) mTOR combo combinations nd 32-40% Fulvestrant 2 line (SOFEA, PALOMA-3) rd 15.4% Fulvestrant 3 line (BELLE-3) 0% monotherapy CBR *CBR is based on ITT 12 Elacestrant single agent CBR at 24 weeks 42% in patient group with mature data set (Parts A+B) Fulv = prior fulvestrant treatment; CDK4/6 = prior CDK4/6 inhibitor treatment; ESR1 = ESR1 mutation detected at baseline; RECIST = patients with RECIST measurable disease. Radius Health, Inc. PROPRIETARY Median Progression Free Survival (mPFS) in ER+ Advanced Breast Cancer for Endocrine Agents Range from 1.8 mo* (mono) to 9.5 mo* (in combo) 10 mo 2nd line SERD combo 2nd line mTOR combo nd 4.6-4.8 mo Fulvestrant 2 line (PALOMA-3, SOFEA ) 3rd line 1.8 mo Fulvestrant 0 (BELLE-3) monotherapy mPFS *mPFS is based on ITT 14 Median Progression Free Survival (mPFS) in ER+ Advanced Breast Cancer for Endocrine Agents Range from 1.8 mo* (mono) to 9.5 mo* (in combo) 10 mo nd 9.2 mo Fulvestrant +Palbociclib 2 line (PALOMA-3) SERD combo nd 7.8 mo Exemestane + Everolimus 2 line (BOLERO-2) mTOR combo combinations nd 4.6-4.8 mo Fulvestrant 2 line (PALOMA-3, SOFEA ) 3rd line 1.8 mo Fulvestrant 0 (BELLE-3) monotherapy mPFS *mPFS is based on ITT Elacestrant single agent mPFS 4.5 months in patient group with mature data set (Parts A+B*) *400 mg tablet data (Part C patients) is not mature for CBR or PFS estimates at this time **CBR at 24 weeks was calculated using the CBR population (ie. all 400mg patients in Part A+B who had at least 1 post baseline RECIST evaluation) 16 Most common (≥10%) treatment-related adverse events • Elacestrant 400 mg administered orally on a continuous daily schedule was well tolerated • Longest 400mg treatment duration now exceeds 1 year • Predominantly G1 and G2 upper GI events (nausea, dyspepsia, vomiting) • Profile supportive of potential for combination with other agents The two patients with G3 transaminase elevations had liver metastases; elevations were transient in one and associated with progressive disease in the liver in the second Radius Health, Inc. PROPRIETARY 17 What is an IDEAL profile for a SERD ? Targeted potent ER receptor degrader Effective in treating resistant disease including ESR1 mutants Safety profile that allows for drug combinations eg: SERD+ CDKi’s PK profile that allows for once a day oral dosing 18 Elacestrant Demonstrates Complete ERa Degradation Comparison with Other Investigational SERDs Human ER+ Breast Cancer Cell Line (MCF7) Cells were treated for 48 hours RAD1901 (nM) AZD9496 (nM) RAD1901 (nM) GDC-0810 (nM) RAD1901 (nM) Bazedoxifene (nM) V 0.1 1 10 100 1000 0.1 1 10 100 1000 V 0.1 1 10 100 1000 0.1 1 10 100 1000 V 0.1 1 10 100 1000 0.1 1 10 100 1000 ERα Vinculin Elacestrant has shown superior activity than comparator oral SERDs 19 Elacestrant Demonstrates Complete Tumor Growth Inhibition Comparison with Other Investigational SERDs ESR1 Mutant Fulvestrant-Resistant Patient Derived Xenograft Model 2 5 0 0 F u lv e s tra n t C o n tr o l 2 0 0
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