8940712.Pdf (2.884Mb)

Total Page:16

File Type:pdf, Size:1020Kb

8940712.Pdf (2.884Mb) US008940712B2 a2) United States Patent (0) Patent No.: US 8,940,712 B2 Olsonet al. (45) Date of Patent: Jan. 27, 2015 (54) MICRO-RNA FAMILY THAT MODULATES 2310/141 (2013.01); CI2N 2310/315 (2013.01); FIBROSIS AND USES THEREOF C1I2N 2310/321 (2013.01); C12N 2310/346 (2013.01); CI2N 2310/3515 (2013.01); C12N (71) Applicant: The Board of Regents, The University 2320/31 (2013.01); C12N 2330/10 (2013.01) of Texas System,Austin, TX (US) USPC. ecsscssssssseesstvesnssnssresnesvesveecee 514/44 A (72) Inventors: Eric N. Olson, Dallas, TX (US); Eva (58) Field of Classification Search van Rooij, Utrecht (NL) USPC ooceecccccsscsecseeseeseeseeseeseeseesseeeeeeesneseees 514/44 A See application file for complete search history. (73) Assignee: The Board of Regents, The University of Texas System, Austin, TX (US) (56) References Cited (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S. PATENT DOCUMENTS U.S.C. 154(6)by I day. 7,232,806 B2 6/2007 Tuschlet al. 7,674,617 B2 3/2010 Kimetal. (21) Appl. No.: 13/840,823 2005/0059005 Al 3/2005 Tuschlet al. 2005/0222399 Al 10/2005 Bentwich (22) Filed: Mar. 15, 2013 2005/0261218 Al 11/2005 Esau etal. 2006/0019286 Al 1/2006 Horvitz et al. (65) Prior Publication Data 2006/0105360 Al 5/2006 Croceet al. 2006/0185027 Al 8/2006 Bartelet al. US 2013/0195891 Al Aug. 1, 2013 2006/0247193 Al 11/2006 Taira etal. 2007/0087335 Al 4/2007 Brahmachari etal. 2007/0092882 Al 4/2007 Wangetal. 2008/0176766 Al 7/2008 Brownetal. (63) Continuation of application No. 12/671,445, filed as 2009/0053718 Al 2/2009 Naguibnevaetal. application No. PCT/US2008/071839 on Jul. 31, sooOaaaoe ‘i eons One "a 2008, now Pat. No. 8,440,636. 2009/0281167 Al 11/2009 Shenad.et&al. (60) Provisional application No. 61/047,014, filed on Apr. (Continued) 22, 2008, provisional application No. 60/980,303, filed on Oct. 16, 2007, provisional application No. FOREIGN PATENT DOCUMENTS 60/952,917,filed on Jul. 31, 2007. EP 1440981 A2 7/2004 (51) Int. Cl. EP 1627925 Al 2/2006 CI2N 15/11 (2006.01) (Continued) A6I1K 31/713 (2006.01) AOIK 67/027 (2006.01) OTHER PUBLICATIONS A61K 38/22 (2006.01) CI2N 9/16 (2006.01) Cheng et al., “MicroRNAs Are Aberrantly Expressed in CIQN 15/113 (2010.01) Hypertrophic Heart,’ Am. J. Pathol. 170(6):1831-1840 (2007). CI2QN 15/85 (2006.01) (Continued) AG6IK 31/7105 (2006.01) A6I1K 31/712 (2006.01) AG6IK 31/7125 2006.01 AGIK 39/395 (3006 01) Primary Examiner — J. E. Angell AG6IK 45/06 (2006.01) (74) Altorney, Agent, or Firm — Cooley LLP A61K 31/07 (2006.01) A6IK 31/355 (2006.01) A6I1K 31/375 (2006.01) (67) ABSTRACT (52) U.S. Cl. The present invention relates to the identification of a CPC wee A61K 31/713 (2013.01); AOLK 67/0276 microRNA family, designated miR-29a-c, that is a key regu- (2013.01); A6LK 38/2242 (2013.01); C12N lator of fibrosis in cardiac tissue. The inventors show that 9/16 (2013.01); CI2N 15/113 (2013.01); CI2N members of the miR-29 family are down-regulated in the 15/8509 (2013.01); AGLK 31/7105 (2013.01); heart tissue in responseto stress, and are up-regulatedin heart A61LK 31/712 (2013.01); A6LK 31/7125 tissue of mice that are resistant to both stress and fibrosis. (2013.01); A6LK 39/3955 (2013.01); A61K Also provided are methods of modulating expression and 45/06 (2013.01); A61K 31/07 (2013.01); A6LK activity of the miR-29 family of miRNAsas a treatment for 31/355 (2013.01); A6LK 31/375 (2013.01); fibrotic disease, including cardiac hypertrophy, skeletal AOLK 2207/30 (2013.01); AOLK 2217/052 muscle fibrosis other fibrosis related diseases and collagen (2013.01); AOLK 2217/075 (2013.01); AOILK loss-related disease. 2217/15 (2013.01); AOLK 2217/206 (2013.01); AOLK 2227/105 (2013.01); AOLK 2267/0375 (2013.01); CI2N 2310/113 (2013.01); C12N 16 Claims, 25 Drawing Sheets US 8,940,712 B2 Page 2 (56) References Cited WO WO2008/061537 A2 5/2008 Wo WO 2008/116267 Al 10/2008 U.S. PATENT DOCUMENTS Wo WO 2008/147839 Al 12/2008 — Wo WO 2009/012263 A2 1/2009 2009/0286969 Al 11/2009 Esauetal. WO WO 2009/026576 Al 2/2009 2009/0291906 Al 11/2009 Esauetal. WO WO 2009/043353 A2 4/2009 2009/0291907 Al 11/2009 Esauetal. WO WO 2009/058818 A2 5/2009 2009/0293148 Al 11/2009 Renetal. WO WO 2009/062169 A2 5/2009 2009/0317369 Al 12/2009 Hosodaet al. WO WO 2009/111375 A2 9/2009 2009/0326049 Al 12/2009 Aristarkhovetal. WO WO 2009/114681 A2 9/2009 2010/0029003 Al 2/2010 Bartel et al. WO WO 2009/121031 Al 10/2009 2010/0087512 Al 4/2010 Tuschlet al. we we sebseoso SS ot 2010/0087513 Al 4/2010 Tuschletal. 2010/0093837 Al 4/2010 Tuschl etal. WO WO 2010/048585 A2 4/2010 2010/0099748 Al 4/2010 Tuschlet al. OTHER PUBLICATIONS 2010/0113561 Al 5/2010 Tuschlet al. Kim, “International Search Report,” 4 pages, from International FOREIGN PATENT DOCUMENTS Patent Appl. No. PCT/US2008/071839,Korean Intellectual Property Office, Daejon, Republic of Korea (mailed Jan. 6, 2009). EP 1777301 A2 4/2007 Rooij et al., “A signature pattern of stress-responsive microRNAsthat EP 1959012 A2 8/2008 can evoke cardiac hypertrophy and heart failure,” Proc. Natl. Acad. EP 2113567 Al 11/2009 Sci. USA 103(48):18255-18260 (2006). JP 2006-5 19008 8/2006 Tatsuguchiet al., “Expression of MicroRNAsis Dynamically Regu- wi0 Wowuloooas9 AQ iOooos lated During Cardiomyocyte Hypertrophy,” J. Mol. Cell. Cardiol. woWo WO 2005/0139012004/076622 A2 3/20059/2004 Po)pasesQuintana8) altoeCon microictoRNAss fifrom mouse and. dhhuman,” wo wo aN40iio ‘i a8 Lagos-Quintanaet al., “Identification of tissue-specific microRNAs wo WO 2005/047505 A2 5/2005 from mouse,” Current Biology, vol. 12:735-739, 2002. ; wo WO 2005/056797 Al 6/2005 Sempere et al., “Expression profiling of mammalian microRNAs Wo WO 2005/118806 A2 12/2005 uncoversa subset ofbrain-expressed microRNAs with possible roles wo WO 2006/033020 A2 3/2006 in murine and human neuronal differentiation”’ Genome Biology, WO WO 2006/033928 A2 3/2006 vol. 5:R13, 2004. — wo WO 2006/081284 A2 8/2006 Mott et al., “miR-29 regulates Mcl-1 protein expression and WO WO 2006/108473 Al 10/2006 apoptosis,” Oncogene, vol. 26: 6133-6 140, 2007. WO WO 2006/111512 Al 10/2006 Heet al., “Overexpression of Micro Ribonucleic Acid 29, Highly WO WO 2006/128245 Al 12/2006 Up-Regulated in Diabetic Rats, Leads to Insulin Resistance in 3T3- wo WO 2006/133022 A2 12/2006 L1 Adipocytes,” Molecular Endocrinology, vol. 21: 2785-2794, Wo WO 2006/137941 A2 12/2006 2007. — WO WO 2007/000668 A2 1/2007 Zhaoet al., “Dysregulation of Cardiogenesis, Cardiac Conduction, WO WO 2007/016548 A2 2/2007 and Cell Cycle in Mice Lacking miRNA-1-2,” Cell, vol. 129: 303- — Wo WO 2007/033023 A2 3/2007 317, 2007. WO WO 2007/042899 A2 4/2007 Van Rooij et al., “Dysregulation of microRNAsafter myocardial wo wo sooooags “ ene infarction reveals a role of miR-29 in cardiac fibrosis,” Proc. Natl. Wo WO 2007/081680 A2 7/9007 Acad. Sci, USA, vol. 105: 13027-13032, 2008. wo WO 2007/081720 A2 7/2007 Spindler, Supplementary European Search Report for European Wo WO 2007/081740 A? 7/2007 Application No. 08797006.7, 10 pages, European Patent Office, The WO WO 2007/109236 A2 9/2007 Hague, mailed Aug. 17, 2011. ~~ Wo WO 2007/112754 A2 10/2007 Pekarsky Y. et al., “Tell expression in chronic lymphocytic leukemia WO WO 2008/016924 A2 2/2008 is regulated by miR-29 and miR-181,” Cancer Research, vol. Wo WO 2008/043521 A2 4/2008 66:11590-11593, 2006. B2 8,940,712 US t “Sid i€ RONNOOVYYWWOSUpOVeLEAY .S BOZ-HyW SINVW (s son aI as) n 32 ov ¥ Y¥ > ¥ 2 DY OAWAYY OD DD VwwEooNnondh pnd os 25 eu; villi dt el LIELTTELEE EL PLE doonmueis (te ton ar ous) non oynynh O29 3D AnnnoSeWSDSS of DW) OS Woo £ 39 5 ® n 1 RR RAMREREREENAR REEMA RED OR ARES REEDE RE RENE RE RRRRAEES aeRee UOLOOTLOLLOOVVWCWOVIOVOWULYELOOWOLIOLUDLOOULULLODOLOSTLLIOOVOR TIOOVOL bog (@ ON GI O8S) YPOLOOLID Sheet LLODYTUT TOOVATULVLOOVOLILOWOLINWOODODDOLLI LOOVOLONDOVOL 338 (€ ‘ON CI OmS) UOLOSTIOLLOOVWUTYOOUDOVDVVLY LOOWNLAOLOVOLOOVIULLOODSOODDLLLIOOUALODDOVEL 8SNOH (Z ‘ON CI OHS) YOLODLIDLLOOVVUWWODEDOWOVULULOOVOLOLUALOOULYLIODOODIOOELLLOOVONONSOVOL NBO (T ‘ON CI OS) 2 2015 OHW-° ane UELUNH 27, FeIE1axS WOO oH 8h «= Jan. G4 £9°Se BOSH «= Patent U.S. U.S. Patent Jan. 27, 2015 Sheet 2 of 25 US 8,940,712 B2 = —— £d bd cepacia ee e1 | aanoese ota UL $"Za he 4001 o oOo oO o o oO 8 2 oO a @ Ss wo ity Tr AON xo e UOISSOIGXS OHIN SABEIOY o Ayynoequoy Teer yseJ @IOUIODILS SS Spee Ly = Ayynoe1yU0D MOjS B2 8,940,712 US 25 of 3 ee aaWwO.eS AqyiyoeRyUED AyioRyqUOg Sheet MOIS ise Rr 2015 27, > Jan. wisipiosAyjodAHneue wanenes> Ssa.js ETaTSEELhe WVCac) BEL oren(Vepe) Patent U.S. B2 Ty tO rgS"O so 8,940,712 US PST Pr S*t z z rst x4 e uojsseidxe st se JHIN® SAnEIOy 25 of 4 Sheet 2015 27, Jan. atCTU Lorene Ayuepungesi goz-yiw Patent U.S. B2 aq-wp “DIA 8,940,712 Spy pexo|y US jeds jeds uols|oxg PSJEIPayy-AD SPiy peyobies 25 of 5 uOTeUIquUIOSSYy snoBojowop Sheet d xo7] d xXo7> 10193/, BunebieL 2015 27, SIV Jan.
Recommended publications
  • (12) United States Patent (10) Patent No.: US 9,498,481 B2 Rao Et Al
    USOO9498481 B2 (12) United States Patent (10) Patent No.: US 9,498,481 B2 Rao et al. (45) Date of Patent: *Nov. 22, 2016 (54) CYCLOPROPYL MODULATORS OF P2Y12 WO WO95/26325 10, 1995 RECEPTOR WO WO99/O5142 2, 1999 WO WOOO/34283 6, 2000 WO WO O1/92262 12/2001 (71) Applicant: Apharaceuticals. Inc., La WO WO O1/922.63 12/2001 olla, CA (US) WO WO 2011/O17108 2, 2011 (72) Inventors: Tadimeti Rao, San Diego, CA (US); Chengzhi Zhang, San Diego, CA (US) OTHER PUBLICATIONS Drugs of the Future 32(10), 845-853 (2007).* (73) Assignee: Auspex Pharmaceuticals, Inc., LaJolla, Tantry et al. in Expert Opin. Invest. Drugs (2007) 16(2):225-229.* CA (US) Wallentin et al. in the New England Journal of Medicine, 361 (11), 1045-1057 (2009).* (*) Notice: Subject to any disclaimer, the term of this Husted et al. in The European Heart Journal 27, 1038-1047 (2006).* patent is extended or adjusted under 35 Auspex in www.businesswire.com/news/home/20081023005201/ U.S.C. 154(b) by Od en/Auspex-Pharmaceuticals-Announces-Positive-Results-Clinical M YW- (b) by ayS. Study (published: Oct. 23, 2008).* This patent is Subject to a terminal dis- Concert In www.concertpharma. com/news/ claimer ConcertPresentsPreclinicalResultsNAMS.htm (published: Sep. 25. 2008).* Concert2 in Expert Rev. Anti Infect. Ther. 6(6), 782 (2008).* (21) Appl. No.: 14/977,056 Springthorpe et al. in Bioorganic & Medicinal Chemistry Letters 17. 6013-6018 (2007).* (22) Filed: Dec. 21, 2015 Leis et al. in Current Organic Chemistry 2, 131-144 (1998).* Angiolillo et al., Pharmacology of emerging novel platelet inhibi (65) Prior Publication Data tors, American Heart Journal, 2008, 156(2) Supp.
    [Show full text]
  • Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report
    Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,784,177 B2 Cohn Et Al
    USOO6784177B2 (12) United States Patent (10) Patent No.: US 6,784,177 B2 Cohn et al. (45) Date of Patent: Aug. 31, 2004 (54) METHODS USING HYDRALAZINE Massie et al., The American Journal of Cardiology, COMPOUNDS AND SOSORBIDE 40:794-801 (1977). DINTRATE OR ISOSORBIDE Kaplan et al., Annals of Internal Medicine, 84:639-645 MONONTRATE (1976). Bauer et al., Circulation, 84(1):35-39 (1991). (75) Inventors: Jay N. Cohn, Minneapolis, MN (US); The SOLVD Investigators, The New England Journal of Medicine, 327(10):685–691 (1992). Peter Carson, Chevy Chase, MD (US) Ziesche et al., Circulation, 87(6):VI56-VI64 (1993). Rector et al., Circulation, 87(6):VI71-VI77 (1993). (73) Assignee: Nitro Med, Inc., Bedford, MA (US) Carson et al., Journal of Cardiac Failure, 5(3):178-187 (Sep. 10, 1999). (*) Notice: Subject to any disclaimer, the term of this Dries et al, The New England Journal of Medicine, patent is extended or adjusted under 35 340(8):609-616 (Feb. 25, 1999). U.S.C. 154(b) by 18 days. Freedman et al, Drugs, 54 (Supplement 3):41-50 (1997). Sherman et al., Cardiologia, 42(2):177-187 (1997). (21) Appl. No.: 10/210,113 Biegelson et al., Coronary Artery Disease, 10:241-256 (1999). (22) Filed: Aug. 2, 2002 Rudd et al, Am. J. Physiol., 277(46):H732–H739 (1999). (65) Prior Publication Data Hammerman et al, Am. J. Physiol., 277(46):H1579–1592 (1999). US 2004/0023967 A1 Feb. 5, 2004 LoScalzo et al., Transactions of the American and Climato logical ASS., 111:158-163 (2000).
    [Show full text]
  • Stems for Nonproprietary Drug Names
    USAN STEM LIST STEM DEFINITION EXAMPLES -abine (see -arabine, -citabine) -ac anti-inflammatory agents (acetic acid derivatives) bromfenac dexpemedolac -acetam (see -racetam) -adol or analgesics (mixed opiate receptor agonists/ tazadolene -adol- antagonists) spiradolene levonantradol -adox antibacterials (quinoline dioxide derivatives) carbadox -afenone antiarrhythmics (propafenone derivatives) alprafenone diprafenonex -afil PDE5 inhibitors tadalafil -aj- antiarrhythmics (ajmaline derivatives) lorajmine -aldrate antacid aluminum salts magaldrate -algron alpha1 - and alpha2 - adrenoreceptor agonists dabuzalgron -alol combined alpha and beta blockers labetalol medroxalol -amidis antimyloidotics tafamidis -amivir (see -vir) -ampa ionotropic non-NMDA glutamate receptors (AMPA and/or KA receptors) subgroup: -ampanel antagonists becampanel -ampator modulators forampator -anib angiogenesis inhibitors pegaptanib cediranib 1 subgroup: -siranib siRNA bevasiranib -andr- androgens nandrolone -anserin serotonin 5-HT2 receptor antagonists altanserin tropanserin adatanserin -antel anthelmintics (undefined group) carbantel subgroup: -quantel 2-deoxoparaherquamide A derivatives derquantel -antrone antineoplastics; anthraquinone derivatives pixantrone -apsel P-selectin antagonists torapsel -arabine antineoplastics (arabinofuranosyl derivatives) fazarabine fludarabine aril-, -aril, -aril- antiviral (arildone derivatives) pleconaril arildone fosarilate -arit antirheumatics (lobenzarit type) lobenzarit clobuzarit -arol anticoagulants (dicumarol type) dicumarol
    [Show full text]
  • Sudden Cardiac Arrest: Studies on Risk and Outcome
    UvA-DARE (Digital Academic Repository) Sudden cardiac arrest: Studies on risk and outcome Blom, M.T. Publication date 2014 Document Version Final published version Link to publication Citation for published version (APA): Blom, M. T. (2014). Sudden cardiac arrest: Studies on risk and outcome. Boxpress. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:05 Oct 2021 SUDDEN CARDIAC ARREST Studies on risk and outcome Marieke Tabo Blom Sudden Cardiac Arrest: studies on risk and outcome Academic thesis, University of Amsterdam, The Netherlands Copyright © 2014 M.T. Blom, Amsterdam, The Netherlands ISBN: 978-90-8891-960-2 Cover design: Proefschriftmaken.nl || Uitgeverij BOXPress Printed & Lay Out by: Proefschriftmaken.nl || Uitgeverij BOXPress Published by: Uitgeverij BOXPress, ‘-Hertogenbosch Financial support by the Dutch Heart Foundation and the Acadamic Medical Center – University of Amsterdam for the publication of this thesis is gratefully acknowledged.
    [Show full text]
  • The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances
    WHO/PSM/QSM/2006.3 The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2006 Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines Medicines Policy and Standards The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 © World Health Organization 2006 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
    [Show full text]
  • Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set
    MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01
    [Show full text]
  • Pharmaceutical Appendix to the Tariff Schedule 2
    Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9
    [Show full text]
  • Marrakesh Agreement Establishing the World Trade Organization
    No. 31874 Multilateral Marrakesh Agreement establishing the World Trade Organ ization (with final act, annexes and protocol). Concluded at Marrakesh on 15 April 1994 Authentic texts: English, French and Spanish. Registered by the Director-General of the World Trade Organization, acting on behalf of the Parties, on 1 June 1995. Multilat ral Accord de Marrakech instituant l©Organisation mondiale du commerce (avec acte final, annexes et protocole). Conclu Marrakech le 15 avril 1994 Textes authentiques : anglais, français et espagnol. Enregistré par le Directeur général de l'Organisation mondiale du com merce, agissant au nom des Parties, le 1er juin 1995. Vol. 1867, 1-31874 4_________United Nations — Treaty Series • Nations Unies — Recueil des Traités 1995 Table of contents Table des matières Indice [Volume 1867] FINAL ACT EMBODYING THE RESULTS OF THE URUGUAY ROUND OF MULTILATERAL TRADE NEGOTIATIONS ACTE FINAL REPRENANT LES RESULTATS DES NEGOCIATIONS COMMERCIALES MULTILATERALES DU CYCLE D©URUGUAY ACTA FINAL EN QUE SE INCORPOR N LOS RESULTADOS DE LA RONDA URUGUAY DE NEGOCIACIONES COMERCIALES MULTILATERALES SIGNATURES - SIGNATURES - FIRMAS MINISTERIAL DECISIONS, DECLARATIONS AND UNDERSTANDING DECISIONS, DECLARATIONS ET MEMORANDUM D©ACCORD MINISTERIELS DECISIONES, DECLARACIONES Y ENTEND MIENTO MINISTERIALES MARRAKESH AGREEMENT ESTABLISHING THE WORLD TRADE ORGANIZATION ACCORD DE MARRAKECH INSTITUANT L©ORGANISATION MONDIALE DU COMMERCE ACUERDO DE MARRAKECH POR EL QUE SE ESTABLECE LA ORGANIZACI N MUND1AL DEL COMERCIO ANNEX 1 ANNEXE 1 ANEXO 1 ANNEX
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,635,273 B1 Loscalz0 Et Al
    USOO6635273B1 (12) United States Patent (10) Patent No.: US 6,635,273 B1 LOScalZ0 et al. (45) Date of Patent: Oct. 21, 2003 (54) METHODS OF TREATING VASCULAR Dries et al, The New England Journal of Medicine, DISEASES CHARACTERIZED BY NITRIC 340(8):609-616 (Feb. 25, 1999). OXDE INSUFFICIENCY Freedman et al, Drugs, 54(Supp. 3):41-50 (1997). Sherman et al., Cardiologia, 42(2):177-187 (1997). (75) Inventors: Joseph Loscalzo, Dover, MA (US); Biegelson et al., Coronary Artery Disease, 10:241-256 Joseph A. Vita, Hingham, MA (US); (1999). Michael D. Loberg, Boston, MA (US); Rudd et al, Am. J. Physiol., 277(46):H732–H739 (1999). Manuel Worcel, Boston, MA (US) Hammerman et al, Am. J. Physiol., 277(46):H1579-H1592 (1999). (73) Assignees: Trustees of Boston University, Boston, LoScalzo et al., Transactions of the American and Climato MA (US); NitroMed, Inc., Bedford, logical ASS., 111:158-163 (2000). MA (US) Cohn et al, The New England Journal of Medicine, 325(5):303-310 (1991). (*) Notice: Subject to any disclaimer, the term of this Cohn et al, The New England Journal of Medicine , patent is extended or adjusted under 35 314(24): 1547–1552 (1986). U.S.C. 154(b) by 0 days. Carson et al., Circulation, Supplement I, 92(8):I31-I32, Abstract No. 0145 (1995). (21) Appl. No.: 09/697,317 (List continued on next page.) (22) Filed: Oct. 27, 2000 Primary Examiner-Jon P. Weber Related U.S. Application Data ASSistant Examiner-Kalash C. Srivastava (60) Provisional application No. 60/179,020, filed on Jan.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2006/0078604 A1 Kanios Et Al
    US 20060078604A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0078604 A1 Kanios et al. (43) Pub. Date: Apr. 13, 2006 (54) TRANSDERMAL DRUG DELIVERY DEVICE Related U.S. Application Data INCLUDING AN OCCLUSIVE BACKING (60) Provisional application No. 60/616,861, filed on Oct. 8, 2004. (75) Inventors: David Kanios, Miami, FL (US); Juan A. Mantelle, Miami, FL (US); Viet Publication Classification Nguyen, Miami, FL (US) (51) Int. Cl. Correspondence Address: A 6LX 9/70 (2006.01) DCKSTEIN SHAPRO MORN & OSHINSKY (52) U.S. Cl. .............................................................. 424/449 LLP (57) ABSTRACT 2101 L Street, NW Washington, DC 20037 (US) A transdermal drug delivery system for the topical applica tion of one or more active agents contained in one or more (73) Assignee: Noven Pharmaceuticals, Inc. polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can (21) Appl. No.: 11/245,180 control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmis (22) Filed: Oct. 7, 2005 sion rate of the polymeric backing layer. Patent Application Publication Apr. 13, 2006 Sheet 1 of 2 US 2006/0078604 A1 Fis ZZZZZZZZZZZZZZZZZZZ :::::::::::::::::::::::::::::::: Patent Application Publication Apr. 13, 2006 Sheet 2 of 2 US 2006/0078604 A1 3. s s 3. a 3 : 8 g US 2006/0078604 A1 Apr. 13, 2006 TRANSIDERMAL DRUG DELVERY DEVICE 0008. In the “classic' reservoir-type device, the active INCLUDING AN OCCLUSIVE BACKING agent is typically dissolved or dispersed in a carrier to yield a non-finite carrier form, Such as, for example, a fluid or gel.
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]