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17Th Annual Research Day Wednesday, October 14, 2020 EUGENE APPLEBAUM COLLEGE OF PHARMACY & HEALTH SCIENCES 17th Annual Research Day Wednesday, October 14, 2020 Table of Contents Organizing Committees .................................................................................................................... 1 Agenda ....................................................................................................................................................... 2 Keynote Speaker: James Thomas, PT, PhD ......................................................................................... 3 Abstracts ................................................................................................................................................... 4 Faculty ...................................................................................................................................................... 4 Postdoctoral Scholars ................................................................................................................................. 5 Health Sciences Graduate Programs .......................................................................................................... 11 Pharmaceutical Sciences Graduate Programs............................................................................................. 23 PharmD Candidates.................................................................................................................................. 46 Undergraduate Students .......................................................................................................................... 69 Organizing Committees Research Committee Paul Kilgore, Chair Malcolm Cutchin, Co-Chair Diane Adamo, Ex-Officio Kyle Burghardt Aloke Dutta Heather Fritz Nora Fritz Arun Iyer Anna Moszcynska Mary Jo Pilat Christine Rabinak Michael J. Rybak MaryAnne Stewart Research Forum Administrative Committee Tiffany Cusmano Marissa Rossman Michelle Strunge 1 Agenda 10:00 a.m. Welcome Catherine Lysack, Ph.D., Interim Dean 10:10 a.m. Housekeeping Diane Adamo, Ph.D., M.S., OTR 10:15 a.m. Keynote Address Introduction: Sara Maher, PT, PhD Keynote Address: James Thomas, PT, PhD 10:50 a.m. Q&A with James Thomas 11:00 a.m. Presentation of Awards STUDENT RESEARCH AWARDS Paul E. Kilgore, MPH, MD, FACP College Research Committee Chair FACULTY RESEARCH AWARDS Paul E. Kilgore, MPH, MD, FACP College Research Committee Chair 2 Keynote Speaker: James Thomas, PT, PhD A professor of physical therapy at Virginia Commonwealth University, James Thomas's primary research focus is on how the central nervous system controls patterns of movement in a kinematically redundant system in healthy individuals and in those individuals with orthopedic or neurological impairments. He earned his B.S. in Physical Therapy at St. Louis University and his Ph.D. in Kinesiology at the University of Illinois at Chicago. After 12 years of clinical experience in orthopedics, he joined Ohio University to teach and initiated the Ohio Musculoskeletal and Neurologic research Institute. He brings an innovative virtual reality research initiative to VCU. The Motor Control Lab (MCL), under the direction of Thomas, has been funded by the NIH since 2004. The primary focus of the MCL is to better understand control of trunk movements and how various orthopedic or neurologic impairments alter that control. He uses state of the art technology, equipment, facilities, and strong research methods to investigate back pain. In addition to offering a creatiVe option to physical therapy treatment in the DPT program, he adds a new dimension to the Ph.D. in Rehabilitation and Movement Science. 3 Abstracts Faculty ABSTRACT NO. F01 Name Jeannetta Greer Category Faculty Title Radiation Therapists Keeping Our Compassion Authors Jeannetta M. Greer, M.S., B.S.R.T (T) Abstract Introduction: Radiation therapists are highly skilled healthcare workers that operate high tech treatment machines to localize and treat malignant and nonmalignant disorders. Provision of emotional support is a key component of care that complements highly skilled technical skills. Objective(s): The purpose of the study is to gain a better understanding of the role of compassion and how it is integrated into clinical care, specifically for cancer patients. Methods: A literature search was conducted to gain a historical and current perspective about the role of compassion. Results: The role of the radiation therapist is described in terms of technical skills, how they demonstrate compassion and the specific benefits of compassion to the patient and the radiation therapist. Conclusion: Compassion is a critical part of clinical care. Efforts to enhance clinical care is even more important at time when we are encouraged to remain distant from each other. 4 Postdoctoral Scholars ABSTRACT NO. PD01 Name Lena Farhat, PharmD Category Pharmaceutical Sciences Graduate Programs Title Evaluation of Physician, Pharmacist, Nurse and Patient Agreement on Key New Medication Counseling Points Authors Lena Farhat, PharmD; Nedeen Berry, PharmD Candidate; David Sengstock, MD, MS; Rajiv John, MD; Anne Prouty, MSN; Sean McConachie, PharmD Abstract Introduction: Research shows that healthcare providers communicate limited information to patients when counseling on medications in both hospital and ambulatory settings. Additionally, research shows that patients often have differing opinions on the relative importance on certain aspects of patient counseling (i.e. side effects) than providers. There are limited studies in the literature assessing differing viewpoints on important elements of patient education and current medication counseling guidelines are paternalistic and do not take into account patient perspectives. Objective(s): Determine the areas of agreement and disagreement between physicians, nurses, pharmacists and patients in the relative importance of counseling points discussed during medication education. Methods: This study is a cross-sectional, quantitative survey to evaluate the beliefs of nurses, pharmacists, physicians and general medicine inpatients regarding major counseling points that are discussed during medication education at Beaumont Hospital, Dearborn. A 15-item electronic survey including demographic and counseling-based questions was developed and will be administered from September 1, 2020 through December 31, 2020. Counseling-based questions will require respondents to rank common counseling points (such as medication name, dose, cost, storage considerations, etc.) into three categories: “very important,” “somewhat important,” and “least important.” Statistical analysis will be performed to assess differences between groups with respect to their opinions and rankings of medication counseling points. The study will target a sample size of 250 respondents to detect a significant difference between groups at a significance level of p < 0.05. Results: Pending Conclusion: Pending 5 ABSTRACT NO. PD02 Name Jitender Gaddameedi Category Pharmaceutical Sciences Graduate Program Title Discovery of Highly Potent and Selective Ku-targeted DNA-PK Inhibitors for Treatment of Cancer 1 2 2 Authors Jitender Dev Gaddameedi , Pamela VanderVere-Carozza , Tyler L. Vernon , Katherine S. Pawelczak3, Leslyn A. Hanakahi4 John J. Turchi2,3 and Navnath S. Gavande1,3* Abstract Introduction: Cancer is one of the leading causes of death and death rate per decade drastically enhancing and the resistant to drug treatment leads to a serious issue. Targeting DNA repair and the DNA damage response for cancer therapy has gained increasing attention with the recent U.S. FDA (December 2014) approval of the poly-ADP ribose polymerase (PARP) inhibitor olaparib (Lynparza, AstraZeneca) as the first DNA repair targeting agent for cancer treatment. DNA double strand breaks (DSBs) are the most cytotoxic of DNA lesions. NHEJ pathway is responsible for the repair of majority of ionizing radiation (IR) induced DNA DSB. The DNA dependent protein kinase (DNA-PK) is a validated target for cancer therapeutics and to date, development of inhibitors for DNA-PK has focused on targeting the active site with ATP mimetics. Our current research is focusing on the unique and innovative approach to inhibiting DNA-PK via blocking the Ku70/80 heterodimer interaction with DNA, an essential step in DNA-PK activation and phosphorylation activity. Objective(s): Our goal is to identify drug-like lead molecules by developing the SAR study and synthesize a series of highly potent and specific DNA-PK inhibitors to treat various cancer. Methods: Structure-based drug design, multi-step synthesis, SAR, Electrophoretic mobility shift assay (EMSA), DNA Intercalation Fluorescence Displacement Assay, Thermal Shift assay and Cellular studies Results: We have successfully developed highly potent and selective DNA-PK inhibitors by targeting Ku- DNA interactions. Conclusion: Our novel DNA-PK inhibitors reduce NHEJ catalyzed DNA DSB repair in vitro and in cell culture models. Synthesis of new series and Structure-activity relationships (SAR) is underway to develop highly potent drug-like Ku inhibitors. 6 ABSTRACT NO. PD03 Name Yi-Ling Hu, MSOT, PhD Category Postdoctoral Scholar Title Change in Frailty Status Predicts Fall Risks among Older Mexican Americans Authors Yi-Ling Hu, MSOT, PhD; Heather Fritz, MSOT, PhD, OTR/L Abstract Introduction: Fall is a serious public health concern for older adults. Mexican American (MA) older adults have higher fall rates compare to their White and Black peers. Frailty is one of the predictors
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